id: gomodel:67086be200002266
title: sphingolipid biosynthetic process (GO:0030148)
taxon: NCBITaxon:4896
status: production
comments:
- 'Orm1, Sac11 and Sac12 are part of the Serine palmitoyltransferase complex, function
  unknown '
- See https://www.aocs.org/wp-content/uploads/2019/07/Fig.2_Saccharomyces_cerevisiae.png
  and https://pathway.yeastgenome.org/YEAST/new-image?type=PATHWAY&object=SPHINGOLIPID-SYN-PWY-1&detail-level=2
activities:
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    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
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      - SGD:S000002775
      provenances:
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        date: '2024-10-23'
        provided_by:
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    provenances:
    - contributor:
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      date: '2024-10-23'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC26H5.13c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0070917
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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      provenances:
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        date: '2024-10-23'
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    provenances:
    - contributor:
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      date: '2024-10-23'
      provided_by:
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    term: GO:0000139
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000305
      reference: GO_REF:0000111
      with_objects:
      - GO:0070916
      provenances:
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        date: '2024-10-23'
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    provenances:
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      date: '2024-10-23'
      provided_by:
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    term: GO:0051999
  causal_associations:
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      reference: GO_REF:0000033
      with_objects:
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      - SGD:S000002775
      provenances:
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        date: '2024-10-23'
        provided_by:
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    provenances:
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      date: '2024-10-23'
      provided_by:
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    predicate: RO:0002629
    downstream_activity: gomodel:67086be200002266/67086be200002492
- id: gomodel:67086be200002266/67086be200002561
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:11514435
      provenances:
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      date: '2024-10-23'
      provided_by:
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    term: PomBase:SPBC32F12.01c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0052714
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
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      reference: PMID:16823372
      provenances:
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        date: '2024-10-23'
        provided_by:
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      reference: GO_REF:0000033
      with_objects:
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      provenances:
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        date: '2024-10-23'
        provided_by:
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    provenances:
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      date: '2024-10-23'
      provided_by:
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    term: GO:0005783
  part_of:
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    evidence:
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      reference: PMID:11514435
      provenances:
      - contributor:
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        date: '2024-10-23'
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      with_objects:
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      provenances:
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      date: '2024-10-23'
      provided_by:
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    term: GO:0046513
  has_input:
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      date: '2024-10-23'
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    term: CHEBI:64997
  has_output:
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      reference: PMID:11514435
      provenances:
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    term: CHEBI:60448
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    term: CHEBI:139051
- id: gomodel:67086be200002266/67086be200002409
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      reference: GO_REF:0000033
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      - RGD:620048
      - FB:FBgn0030300
      - dictyBase:DDB_G0284545
      - FB:FBgn0052484
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      - UniProtKB:Q9NYA1
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    term: PomBase:SPAC4A8.07c
  molecular_function:
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    term: GO:0017050
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
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      reference: GO_REF:0000024
      with_objects:
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      date: '2024-10-23'
      provided_by:
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    term: GO:0005783
  part_of:
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    evidence:
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      with_objects:
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      provenances:
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      date: '2024-10-23'
      provided_by:
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    term: GO:0046512
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      with_objects:
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      provided_by:
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    term: CHEBI:57756
  has_output:
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    term: CHEBI:60119
- id: gomodel:67086be200002266/67086be200002523
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      - CGD:CAL0000176496
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      provenances:
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        provided_by:
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      date: '2024-10-23'
      provided_by:
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    term: PomBase:SPCC4F11.04c
  molecular_function:
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    term: GO:0000030
  occurs_in:
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    evidence:
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      reference: PMID:20388730
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      date: '2024-10-23'
      provided_by:
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    term: GO:0033106
  part_of:
    type: BiologicalProcessAssociation
    evidence:
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      reference: PMID:20388730
      with_objects:
      - PomBase:SPAC2F3.01
      provenances:
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      provenances:
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      with_objects:
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      date: '2024-10-23'
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    term: GO:0051999
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    term: CHEBI:57527
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    term: CHEBI:64997
- id: gomodel:67086be200002266/67086be200002454
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      provided_by:
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    term: PomBase:SPAC19G12.08
  molecular_function:
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- id: gomodel:67086be200002266/67086be200002381
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    term: PomBase:SPAC1A6.09c
  molecular_function:
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        date: '2024-10-23'
        provided_by:
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    provenances:
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      date: '2024-10-23'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC3H8.06
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0045140
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000305
      reference: GO_REF:0000111
      with_objects:
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      - http://www.pombase.org
    term: GO:0000139
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    evidence:
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      reference: GO_REF:0000111
      with_objects:
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    - contributor:
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      date: '2024-10-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0051999
  has_input:
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    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
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      date: '2025-03-20'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:16749
  - type: MoleculeAssociation
    evidence:
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      reference: GO_REF:0000024
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      provenances:
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      date: '2025-03-20'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:16749
  has_output:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
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      provenances:
      - contributor:
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    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2024-10-23'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:64916
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000001487
      provenances:
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        - https://orcid.org/0009-0003-9059-1333
        date: '2025-03-20'
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    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-03-20'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:17815
- id: gomodel:67086be200002266/67086be200002404
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2024-10-23'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:36080
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0017040
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2024-10-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0005783
  part_of:
    type: BiologicalProcessAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2024-10-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0030148
  has_input:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-03-20'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:52639
  has_output:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2024-10-23'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:57756
objects:
- id: GO:0004758
  label: serine C-palmitoyltransferase activity
  type: gocam:Object
- id: GO:0017059
  label: serine palmitoyltransferase complex
  type: gocam:Object
- id: GO:0030148
  label: sphingolipid biosynthetic process
  type: gocam:Object
- id: GO:0005783
  label: endoplasmic reticulum
  type: gocam:Object
- id: PomBase:SPBC18E5.02c
  label: lcb1 Spom
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPAC21E11.08
  label: lcb2 Spom
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPBC119.09c
  label: orm1 Spom
  type: gocam:Object
- id: PomBase:SPBC19F5.03
  label: sac11 Spom
  type: gocam:Object
- id: PomBase:SPAC3C7.01c
  label: sac12 Spom
  type: gocam:Object
- id: PomBase:SPAC23A1.05
  label: tsc3 Spom
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:57379
  label: palmitoyl-CoA(4-)
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: GO:0005789
  label: endoplasmic reticulum membrane
  type: gocam:Object
- id: GO:0033106
  label: cis-Golgi network membrane
  type: gocam:Object
- id: GO:0005794
  label: Golgi apparatus
  type: gocam:Object
- id: GO:0036042
  label: long-chain fatty acyl-CoA binding
  type: gocam:Object
- id: PomBase:SPBC1539.06
  label: acb1 Spom
  type: gocam:Object
- id: GO:0006631
  label: fatty acid metabolic process
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:138261
  label: very long-chain fatty acyl-CoA(4-)
  type: gocam:Object
- id: ECO:0000501
  label: evidence used in automatic assertion
  type: gocam:Object
- id: CHEBI:57384
  label: malonyl-CoA(5-)
  type: gocam:Object
- id: GO:0102772
  label: sphingolipid C4-monooxygenase activity
  type: gocam:Object
- id: PomBase:SPBC887.15c
  label: sur2 Spom
  type: gocam:Object
- id: ECO:0000316
  label: genetic interaction evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:57817
  label: sphinganine(1+)
  type: gocam:Object
- id: CHEBI:64124
  label: phytosphingosine(1+)
  type: gocam:Object
- id: CHEBI:52639
  label: N-acylsphingosine
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:139051
  label: phytoceramide
  type: gocam:Object
- id: CHEBI:16749
  label: 1-phosphatidyl-1D-myo-inositol
  type: gocam:Object
- id: CHEBI:17815
  label: 1,2-diacyl-sn-glycerol
  type: gocam:Object
- id: GO:0045140
  label: inositol phosphoceramide synthase activity
  type: gocam:Object
- id: PomBase:SPAC3H8.06
  label: aur1 Spom
  type: gocam:Object
- id: GO:0006676
  label: mannosyl diphosphorylinositol ceramide metabolic process
  type: gocam:Object
- id: GO:0000139
  label: Golgi membrane
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: CHEBI:57527
  label: GDP-alpha-D-mannose(2-)
  type: gocam:Object
- id: CHEBI:57880
  label: 1-phosphatidyl-1D-myo-inositol(1-)
  type: gocam:Object
- id: CHEBI:62682
  label: inositol phosphomannosylinositol phosphoceramide
  type: gocam:Object
- id: CHEBI:17115
  label: L-serine
  type: gocam:Object
- id: GO:0008047
  label: enzyme activator activity
  type: gocam:Object
- id: GO:0047560
  label: 3-dehydrosphinganine reductase activity
  type: gocam:Object
- id: PomBase:SPCC1450.15
  label: SPCC1450.15 Spom
  type: gocam:Object
- id: GO:0009922
  label: fatty acid elongase activity
  type: gocam:Object
- id: PomBase:SPAC1639.01c
  label: elo1 Spom
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: GO:0141040
  label: very-long-chain 3-oxoacyl-CoA reductase activity
  type: gocam:Object
- id: PomBase:SPAC4G9.15
  label: ifa38 Spom
  type: gocam:Object
- id: GO:0018812
  label: 3-hydroxyacyl-CoA dehydratase activity
  type: gocam:Object
- id: PomBase:SPBC19C2.15c
  label: phs1 Spom
  type: gocam:Object
- id: GO:0019166
  label: trans-2-enoyl-CoA reductase (NADPH) activity
  type: gocam:Object
- id: PomBase:SPBC646.07c
  label: tsc13 Spom
  type: gocam:Object
- id: PomBase:SPAC1B2.03c
  label: elo2 Spom
  type: gocam:Object
- id: GO:0050291
  label: sphingosine N-acyltransferase activity
  type: gocam:Object
- id: PomBase:SPBC3E7.15c
  label: lac1 Spom
  type: gocam:Object
- id: GO:0046513
  label: ceramide biosynthetic process
  type: gocam:Object
- id: PomBase:SPAC1A6.09c
  label: lag1 Spom
  type: gocam:Object
- id: GO:0042284
  label: sphingolipid delta-4 desaturase activity
  type: gocam:Object
- id: PomBase:SPBC3B8.07c
  label: dsd1 Spom
  type: gocam:Object
- id: CHEBI:139048
  label: dihydroceramide
  type: gocam:Object
- id: GO:0017040
  label: N-acylsphingosine amidohydrolase activity
  type: gocam:Object
- id: CHEBI:36080
  label: protein
  type: gocam:Object
- id: CHEBI:57756
  label: sphingosine(1+)
  type: gocam:Object
- id: GO:0017050
  label: obsolete D-erythro-sphingosine kinase activity
  type: gocam:Object
- id: PomBase:SPAC4A8.07c
  label: lcb4 Spom
  type: gocam:Object
- id: GO:0046512
  label: sphingosine biosynthetic process
  type: gocam:Object
- id: GO:0042392
  label: sphingosine-1-phosphate phosphatase activity
  type: gocam:Object
- id: PomBase:SPAC823.11
  label: sgp1 Spom
  type: gocam:Object
- id: CHEBI:60119
  label: sphingosine 1-phosphate(1-)
  type: gocam:Object
- id: PomBase:SPAC19G12.08
  label: scs7 Spom
  type: gocam:Object
- id: GO:0051999
  label: mannosyl-inositol phosphorylceramide biosynthetic process
  type: gocam:Object
- id: GO:0097001
  label: ceramide binding
  type: gocam:Object
- id: PomBase:SPCC584.11c
  label: svf1 Spom
  type: gocam:Object
- id: GO:0035621
  label: ER to Golgi ceramide transport
  type: gocam:Object
- id: GO:0003674
  label: molecular_function
  type: gocam:Object
- id: PomBase:SPBC36B7.02
  label: svf2 Spom
  type: gocam:Object
- id: ECO:0000307
  label: no evidence data found used in manual assertion
  type: gocam:Object
- id: GO:0070917
  label: inositol phosphoceramide synthase regulator activity
  type: gocam:Object
- id: PomBase:SPAC26H5.13c
  label: kei1 Spom
  type: gocam:Object
- id: CHEBI:64916
  label: inositol phosphoceramide(1-)
  type: gocam:Object
- id: GO:0103064
  label: inositol phosphorylceramide mannosyltransferase activity
  type: gocam:Object
- id: PomBase:SPAC2F3.01
  label: imt1 Spom
  type: gocam:Object
- id: GO:0000030
  label: mannosyltransferase activity
  type: gocam:Object
- id: PomBase:SPCC4F11.04c
  label: imt2 Spom
  type: gocam:Object
- id: PomBase:SPAC17G8.11c
  label: imt3 Spom
  type: gocam:Object
- id: PomBase:SPAC27E2.07
  label: pvg2 Spom
  type: gocam:Object
- id: GO:0052714
  label: mannosyl-inositol phosphorylceramide phospholipase activity
  type: gocam:Object
- id: PomBase:SPBC32F12.01c
  label: css1 Spom
  type: gocam:Object
- id: CHEBI:64997
  label: mannosylinositol phosphorylceramide(1-)
  type: gocam:Object
- id: CHEBI:60448
  label: mannose-1D-myo-inositol 1-phosphate
  type: gocam:Object
- id: GO:0017128
  label: phospholipid scramblase activity
  type: gocam:Object
- id: PomBase:SPAPB1A10.07c
  label: SPAPB1A10.07c Spom
  type: gocam:Object
- id: ECO:0000255
  label: match to sequence model evidence used in manual assertion
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0009-0003-9059-1333
  date: '2025-03-25'
  provided_by:
  - http://www.pombase.org
