id: gomodel:662af8fa00000499
title: 'isoprenoid biosynthetic process (GO:0008299) '
taxon: NCBITaxon:4896
status: production
comments:
- 'Automated change 2025-06-12: GO:0019408 replaced by GO:0043048'
- 'I got a bit confused around the dpo9/fps1 part. These 2 appear to be mutifunctional
  /and similar / but I don''t know which does what

  '
- https://link.springer.com/article/10.1007/s11274-019-2673-2/figures/1
- pombe does not synthesize geranyl diphosphate
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    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000033324
      - PomBase:SPAC4D7.04c
      - SGD:S000004707
      - UniProtKB:Q86SQ9
      - SGD:S000000206
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-26'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-26'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC4D7.04c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0045547
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-25'
      provided_by:
      - http://www.pombase.org
    term: GO:0098554
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:25066056
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-26'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000815984
      - PomBase:SPAC4D7.04c
      - SGD:S000004707
      - CGD:CAL0000188102
      - SGD:S000000206
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-26'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-26'
      provided_by:
      - http://www.pombase.org
    term: GO:0043048
  has_input:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN001700951
      - TAIR:locus:2139514
      - SGD:S000001233
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN001700951
      - TAIR:locus:2139514
      - SGD:S000001233
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN001700951
      - TAIR:locus:2139514
      - SGD:S000001233
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-28'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-28'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:175763
  has_output:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-08'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:27845
objects:
- id: GO:0004337
  label: (2E,6E)-farnesyl diphosphate synthase activity
  type: gocam:Object
- id: PomBase:SPBC36.06c
  label: spo9 Spom
  type: gocam:Object
- id: GO:0045337
  label: farnesyl diphosphate biosynthetic process
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0004420
  label: hydroxymethylglutaryl-CoA reductase (NADPH) activity
  type: gocam:Object
- id: PomBase:SPCC162.09c
  label: hmg1 Spom
  type: gocam:Object
- id: GO:0010142
  label: farnesyl diphosphate biosynthetic process, mevalonate pathway
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: GO:0003985
  label: acetyl-CoA C-acetyltransferase activity
  type: gocam:Object
- id: PomBase:SPBC215.09c
  label: erg10 Spom
  type: gocam:Object
- id: GO:0004421
  label: hydroxymethylglutaryl-CoA synthase activity
  type: gocam:Object
- id: PomBase:SPAC4F8.14c
  label: hcs1 Spom
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: GO:0004496
  label: mevalonate kinase activity
  type: gocam:Object
- id: PomBase:SPAC13G6.11c
  label: erg12 Spom
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: GO:0004631
  label: phosphomevalonate kinase activity
  type: gocam:Object
- id: PomBase:SPAC343.01c
  label: erg8 Spom
  type: gocam:Object
- id: GO:0004163
  label: diphosphomevalonate decarboxylase activity
  type: gocam:Object
- id: PomBase:SPAC24C9.03
  label: mvd1 Spom
  type: gocam:Object
- id: ECO:0000303
  label: author statement without traceable support used in manual assertion
  type: gocam:Object
- id: GO:0004452
  label: isopentenyl-diphosphate delta-isomerase activity
  type: gocam:Object
- id: PomBase:SPBC106.15
  label: idi1 Spom
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: GO:0051996
  label: squalene synthase [NAD(P)H] activity
  type: gocam:Object
- id: PomBase:SPBC646.05c
  label: erg9 Spom
  type: gocam:Object
- id: GO:0006696
  label: ergosterol biosynthetic process
  type: gocam:Object
- id: GO:0098554
  label: cytoplasmic side of endoplasmic reticulum membrane
  type: gocam:Object
- id: ECO:0000316
  label: genetic interaction evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPAC6F12.13c
  label: fps1 Spom
  type: gocam:Object
- id: GO:0045547
  label: ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate
    specific] activity
  type: gocam:Object
- id: PomBase:SPAC4D7.04c
  label: rer2 Spom
  type: gocam:Object
- id: GO:0043048
  label: dolichyl monophosphate biosynthetic process
  type: gocam:Object
- id: GO:0005743
  label: mitochondrial inner membrane
  type: gocam:Object
- id: CHEBI:27845
  label: ditrans,polycis-polyprenyl diphosphate
  type: gocam:Object
- id: GO:0005789
  label: endoplasmic reticulum membrane
  type: gocam:Object
- id: GO:0005759
  label: mitochondrial matrix
  type: gocam:Object
- id: CHEBI:16584
  label: isopentenyl diphosphate
  type: gocam:Object
- id: CHEBI:128769
  label: isopentenyl diphosphate(3-)
  type: gocam:Object
- id: CHEBI:15440
  label: squalene
  type: gocam:Object
- id: GO:0004722
  label: protein serine/threonine phosphatase activity
  type: gocam:Object
- id: PomBase:SPCC1739.12
  label: ppe1 Spom
  type: gocam:Object
- id: GO:2001211
  label: negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate
    pathway
  type: gocam:Object
- id: GO:0004865
  label: protein serine/threonine phosphatase inhibitor activity
  type: gocam:Object
- id: PomBase:SPBC646.13
  label: sds23 Spom
  type: gocam:Object
- id: CHEBI:175763
  label: 2-trans,6-trans-farnesyl diphosphate(3-)
  type: gocam:Object
- id: GO:0022857
  label: transmembrane transporter activity
  type: gocam:Object
- id: CHEBI:36080
  label: protein
  type: gocam:Object
- id: GO:0006744
  label: ubiquinone biosynthetic process
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  - https://orcid.org/0009-0003-9059-1333
  date: '2025-06-12'
  provided_by:
  - http://www.pombase.org
