id: gomodel:665912ed00000015
title: tricarboxylic acid cycle (GO:0006099)
taxon: NCBITaxon:4896
status: production
comments:
- 'Automated change 2025-04-24: GO:0004108 replaced by GO:0036440'
- KGD4 is thought to act as an adaptor or stabilizing protein that facilitates the
  interaction between these three core subunits, particularly helping to link the
  E2 component (DLST) with the E3 component (DLD).
- aco2 is TCA in S. cerevisiae when glucose is limiting
- 'directons, particularly fumerate hydratase  /dehydratase

  '
activities:
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  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000568360
      - UniProtKB:Q02218
      - RGD:1561359
      - UniProtKB:P0AFG3
      provenances:
      - contributor:
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        date: '2024-06-17'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-06-17'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC3H7.03c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004591
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
      - contributor:
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        date: '2024-06-17'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000568260
      - UniProtKB:Q9ULD0
      - UniProtKB:Q02218
      - SGD:S000001387
      - MGI:MGI:1098267
      provenances:
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        date: '2024-06-17'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-06-17'
      provided_by:
      - http://www.pombase.org
    term: GO:0005739
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000568360
      - FB:FBgn0010352
      - UniProtKB:P9WIS5
      - RGD:1310916
      - RGD:1561359
      - UniProtKB:P0AFG3
      provenances:
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        date: '2024-06-17'
        provided_by:
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    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-06-17'
      provided_by:
      - http://www.pombase.org
    term: GO:0006099
  causal_associations:
  - type: CausalAssociation
    evidence:
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      reference: GO_REF:0000033
      with_objects:
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      - UniProtKB:Q02218
      - RGD:1561359
      - UniProtKB:P0AFG3
      provenances:
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      date: '2024-06-17'
      provided_by:
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    predicate: RO:0002413
    downstream_activity: gomodel:665912ed00000015/666b894f00000413
- id: gomodel:665912ed00000015/665912ed00000174
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:7903653
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-06-01'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000269
      reference: PMID:7903653
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-06-01'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000216787
      - RGD:2863
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      - TAIR:locus:2127993
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      date: '2024-06-01'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC902.05c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004449
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000250
      reference: GO_REF:0000024
      with_objects:
      - UniProtKB:P28241
      provenances:
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    provenances:
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      date: '2024-06-01'
      provided_by:
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    term: GO:0005759
  part_of:
    type: BiologicalProcessAssociation
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      reference: PMID:7903653
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-06-01'
        provided_by:
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    - term: ECO:0000318
      reference: GO_REF:0000033
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      - PomBase:SPAC11G7.03
      - FB:FBgn0038922
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      - PomBase:SPBC902.05c
      - UniProtKB:O43837
      - RGD:621881
      - RGD:2863
      provenances:
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    provenances:
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      date: '2024-06-01'
      provided_by:
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    term: GO:0006099
  causal_associations:
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      provenances:
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        date: '2024-10-14'
        provided_by:
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    - term: ECO:0000269
      reference: PMID:7903653
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-10-14'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
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      - PomBase:SPAC11G7.03
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        date: '2024-10-14'
        provided_by:
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    - term: ECO:0000315
      reference: PMID:7903653
      provenances:
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        date: '2024-10-14'
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        - http://www.pombase.org
    provenances:
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      date: '2024-10-14'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:665912ed00000015/666b894f00000395
  - type: CausalAssociation
    evidence:
    - term: ECO:0000269
      reference: PMID:7903653
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-10-14'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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      - PomBase:SPAC11G7.03
      provenances:
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    provenances:
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    downstream_activity: gomodel:665912ed00000015/666b894f00000395
- id: gomodel:665912ed00000015/684b6c8100000262
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000501
      reference: GO_REF:0000116
      with_objects:
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      provenances:
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      date: '2025-06-13'
      provided_by:
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    term: PomBase:SPBC17A3.09c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0016979
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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      - SGD:S000003582
      - MGI:MGI:3645211
      provenances:
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    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-06-13'
      provided_by:
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    term: GO:0005739
  part_of:
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    evidence:
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      reference: GO_REF:0000111
      with_objects:
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      provenances:
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      date: '2025-06-13'
      provided_by:
      - http://www.pombase.org
    term: GO:0009249
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000501
      reference: GO_REF:0000116
      with_objects:
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      provenances:
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        date: '2025-06-13'
        provided_by:
        - http://www.pombase.org
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      date: '2025-06-13'
      provided_by:
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  - type: CausalAssociation
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- id: gomodel:665912ed00000015/665912ed00000075
  enabled_by:
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    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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      - UniProtKB:Q8ILE9
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    term: PomBase:SPCC1620.08
  molecular_function:
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    term: GO:0004775
  occurs_in:
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    evidence:
    - term: ECO:0007005
      reference: PMID:16823372
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        provided_by:
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      provided_by:
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      reference: GO_REF:0000033
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    term: GO:0006099
  has_input:
  - type: MoleculeAssociation
    evidence:
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      reference: GO_REF:0000033
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  causal_associations:
  - type: CausalAssociation
    evidence: []
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  - type: CausalAssociation
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    term: PomBase:SPAC1556.02c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0008177
  occurs_in:
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    evidence:
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    term: GO:0005739
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    evidence:
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      date: '2025-02-21'
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        provided_by:
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    - term: ECO:0000318
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    term: CHEBI:26806
  has_output:
  - type: MoleculeAssociation
    evidence:
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      reference: GO_REF:0000033
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  label: aconitate hydratase activity
  type: gocam:Object
- id: PomBase:SPAC24C9.06c
  label: aco1 Spom
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: GO:0004449
  label: isocitrate dehydrogenase (NAD+) activity
  type: gocam:Object
- id: PomBase:SPAC11G7.03
  label: idh1 Spom
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: GO:0004775
  label: succinate-CoA ligase (ADP-forming) activity
  type: gocam:Object
- id: PomBase:SPAC16E8.17c
  label: sca1 Spom
  type: gocam:Object
- id: GO:0005739
  label: mitochondrion
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPCC1620.08
  label: lsc2 Spom
  type: gocam:Object
- id: GO:0008177
  label: succinate dehydrogenase (quinone) activity
  type: gocam:Object
- id: PomBase:SPAC1556.02c
  label: sdh1 Spom
  type: gocam:Object
- id: GO:0004333
  label: fumarate hydratase activity
  type: gocam:Object
- id: PomBase:SPCC18.18c
  label: fum1 Spom
  type: gocam:Object
- id: GO:0030060
  label: L-malate dehydrogenase (NAD+) activity
  type: gocam:Object
- id: PomBase:SPCC306.08c
  label: mdh1 Spom
  type: gocam:Object
- id: PomBase:SPBC902.05c
  label: idh2 Spom
  type: gocam:Object
- id: GO:0004591
  label: oxoglutarate dehydrogenase (succinyl-transferring) activity
  type: gocam:Object
- id: PomBase:SPBC3H7.03c
  label: kgd1 Spom
  type: gocam:Object
- id: GO:0004149
  label: dihydrolipoyllysine-residue succinyltransferase activity
  type: gocam:Object
- id: PomBase:SPBC776.15c
  label: kgd2 Spom
  type: gocam:Object
- id: GO:0030674
  label: protein-macromolecule adaptor activity
  type: gocam:Object
- id: PomBase:SPBC21B10.14
  label: kgd4 Spom
  type: gocam:Object
- id: CHEBI:17694
  label: dihydrolipoamide
  type: gocam:Object
- id: GO:0004148
  label: dihydrolipoyl dehydrogenase (NADH) activity
  type: gocam:Object
- id: PomBase:SPAC1002.09c
  label: dld1 Spom
  type: gocam:Object
- id: CHEBI:15380
  label: succinyl-CoA
  type: gocam:Object
- id: CHEBI:15846
  label: NAD(+)
  type: gocam:Object
- id: GO:0043495
  label: protein-membrane adaptor activity
  type: gocam:Object
- id: PomBase:SPCC330.12c
  label: sdh3 Spom
  type: gocam:Object
- id: GO:0006121
  label: mitochondrial electron transport, succinate to ubiquinone
  type: gocam:Object
- id: ECO:0000501
  label: evidence used in automatic assertion
  type: gocam:Object
- id: GO:0009055
  label: electron transfer activity
  type: gocam:Object
- id: PomBase:SPAC140.01
  label: sdh2 Spom
  type: gocam:Object
- id: GO:0045273
  label: respiratory chain complex II (succinate dehydrogenase)
  type: gocam:Object
- id: PomBase:SPBP23A10.16
  label: tim18 Spom
  type: gocam:Object
- id: GO:0016156
  label: fumarate reductase (NADH) activity
  type: gocam:Object
- id: PomBase:SPAC17A2.05
  label: osm1 Spom
  type: gocam:Object
- id: GO:0006106
  label: fumarate metabolic process
  type: gocam:Object
- id: CHEBI:29806
  label: fumarate(2-)
  type: gocam:Object
- id: CHEBI:26806
  label: succinate
  type: gocam:Object
- id: CHEBI:57945
  label: NADH(2-)
  type: gocam:Object
- id: CHEBI:16452
  label: oxaloacetate(2-)
  type: gocam:Object
- id: CHEBI:57288
  label: acetyl-CoA(4-)
  type: gocam:Object
- id: CHEBI:16947
  label: citrate(3-)
  type: gocam:Object
- id: PomBase:SPBP4H10.15
  label: aco2 Spom
  type: gocam:Object
- id: GO:0005743
  label: mitochondrial inner membrane
  type: gocam:Object
- id: CHEBI:57287
  label: coenzyme A(4-)
  type: gocam:Object
- id: GO:0016979
  label: lipoate-protein ligase activity
  type: gocam:Object
- id: PomBase:SPBC17A3.09c
  label: aim22 Spom
  type: gocam:Object
- id: GO:0009249
  label: protein lipoylation
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  - https://orcid.org/0009-0003-9059-1333
  date: '2025-07-23'
  provided_by:
  - http://www.pombase.org
