id: gomodel:67b1629100004168
title: polyamine biosynthetic process (GO:0006596)
taxon: NCBITaxon:4896
status: production
comments:
- 'Automated change 2025-03-27: GO:0019547 replaced by GO:0000050'
- I left the agmitases out of the model for now until we have better evidence that
  they are really agmitases
activities:
- id: gomodel:67b1629100004168/67b1629100004344
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000170807
      - TAIR:locus:2076834
      - TAIR:locus:2144985
      - SGD:S000005412
      - MGI:MGI:1333111
      - WB:WBGene00004875
      - RGD:2104
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBP4H10.05c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004014
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000170807
      - dictyBase:DDB_G0275567
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:12149471
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000170807
      - WB:WBGene00004875
      - RGD:2104
      - PomBase:SPBP4H10.05c
      - dictyBase:DDB_G0275567
      - TAIR:locus:2076834
      - TAIR:locus:2144985
      - SGD:S000005412
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: GO:0008295
  has_input:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:59789
  has_output:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:57443
- id: gomodel:67b1629100004168/67b1629100004250
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN001616256
      - MGI:MGI:109492
      - UniProtKB:Q9UMX2
      - UniProtKB:P54368
      - UniProtKB:O95190
      - RGD:3219
      - MGI:MGI:109433
      - MGI:MGI:1858170
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC577.14c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0008073
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000303
      reference: GO_REF:0000051
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-20'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-20'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000303
      reference: GO_REF:0000051
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-20'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-20'
      provided_by:
      - http://www.pombase.org
    term: GO:1901305
  causal_associations:
  - type: CausalAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002630
    downstream_activity: gomodel:67b1629100004168/67b1629100004218
  - type: CausalAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN001616256
      - MGI:MGI:109492
      - UniProtKB:Q9UMX2
      - UniProtKB:P54368
      - UniProtKB:O95190
      - RGD:3219
      - MGI:MGI:109433
      - MGI:MGI:1858170
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN001616256
      - MGI:MGI:109492
      - UniProtKB:Q9UMX2
      - UniProtKB:P54368
      - UniProtKB:O95190
      - RGD:3219
      - MGI:MGI:109433
      - MGI:MGI:1858170
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002630
    downstream_activity: gomodel:67b1629100004168/67b1629100004218
- id: gomodel:67b1629100004168/67b1629100004218
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000159726
      - RGD:3227
      - UniProtKB:Q9HVQ3
      - MGI:MGI:97402
      - UniProtKB:Q8IJ77
      - CGD:CAL0000182839
      - SGD:S000001667
      - UniProtKB:P11926
      - WB:WBGene00003844
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC144.04c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004586
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000159726
      - UniProtKB:Q9HVQ3
      - WB:WBGene00003844
      - MGI:MGI:97402
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: GO:0033387
  has_input:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000159726
      - RGD:3227
      - UniProtKB:Q9HVQ3
      - MGI:MGI:97402
      - UniProtKB:Q8IJ77
      - CGD:CAL0000182839
      - SGD:S000001667
      - UniProtKB:P11926
      - WB:WBGene00003844
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000159726
      - RGD:3227
      - UniProtKB:Q9HVQ3
      - MGI:MGI:97402
      - UniProtKB:Q8IJ77
      - CGD:CAL0000182839
      - SGD:S000001667
      - UniProtKB:P11926
      - WB:WBGene00003844
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:46911
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:46911
  has_output:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:326268
- id: gomodel:67b1629100004168/67b1629100004229
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000316
      reference: PMID:7985419
      with_objects:
      - SGD:S000006032
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000316
      reference: PMID:20435771
      with_objects:
      - PomBase:SPAC3H1.07
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000144386
      - RGD:2151
      - PomBase:SPAC3H1.07
      - UniProtKB:P78540
      - UniProtKB:Q12611
      - PomBase:SPBP26C9.02c
      - UniProtKB:P39138
      - CGD:CAL0000174553
      - UniProtKB:C4LSS0
      - RGD:2150
      - SGD:S000006032
      - MGI:MGI:88070
      - UniProtKB:Q8I384
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBP26C9.02c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004053
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000316
      reference: PMID:7985419
      with_objects:
      - SGD:S000006032
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000144387
      - SGD:S000006032
      - PomBase:SPBP26C9.02c
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000316
      reference: PMID:7985419
      with_objects:
      - SGD:S000006032
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000144386
      - PomBase:SPBP26C9.02c
      - UniProtKB:C4LSS0
      - CGD:CAL0000174553
      - PomBase:SPAC3H1.07
      - RGD:2151
      - SGD:S000006032
      - RGD:2150
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: GO:0000050
  has_input:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:16467
  has_output:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:16199
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000316
      reference: PMID:7985419
      with_objects:
      - SGD:S000006032
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000316
      reference: PMID:20435771
      with_objects:
      - PomBase:SPAC3H1.07
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000144386
      - RGD:2151
      - PomBase:SPAC3H1.07
      - UniProtKB:P78540
      - UniProtKB:Q12611
      - PomBase:SPBP26C9.02c
      - UniProtKB:P39138
      - CGD:CAL0000174553
      - UniProtKB:C4LSS0
      - RGD:2150
      - SGD:S000006032
      - MGI:MGI:88070
      - UniProtKB:Q8I384
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:46911
- id: gomodel:67b1629100004168/67b1629100004380
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000250
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000004136
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC12C2.07c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0016768
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000168362
      - UniProtKB:P09158
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000250
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000004136
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: GO:0006597
  has_input:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000168362
      - SGD:S000006273
      - UniProtKB:Q8II73
      - TAIR:locus:2016129
      - TAIR:locus:2034903
      - UniProtKB:P19623
      - RGD:620796
      - TAIR:locus:2163771
      - UniProtKB:Q9WZC2
      - UniProtKB:P09158
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:57443
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000250
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000004136
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:57834
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000250
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000004136
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:57834
  has_output:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000250
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000004136
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000250
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000004136
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:17509
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:45725
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:17509
- id: gomodel:67b1629100004168/680ad14200003347
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000316
      reference: PMID:10620770
      with_objects:
      - SGD:S000004170
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-05-10'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000239344
      - RGD:3050
      - PomBase:SPBC14F5.05c
      - TAIR:locus:2196160
      - UniProtKB:Q586F9
      - UniProtKB:Q586G3
      - RGD:619985
      - UniProtKB:P31153
      - UniProtKB:P0A817
      - SGD:S000004170
      - UniProtKB:Q586G1
      - MGI:MGI:2443731
      - TAIR:locus:2058011
      - UniProtKB:Q7K6A4
      - WB:WBGene00008205
      - UniProtKB:Q00266
      - SGD:S000002910
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-05-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-05-10'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC14F5.05c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004478
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-05-10'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000239344
      - UniProtKB:P0A817
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-05-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-05-10'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000239344
      - UniProtKB:P0A817
      - UniProtKB:P31153
      - RGD:619985
      - SGD:S000002910
      - UniProtKB:Q00266
      - WB:WBGene00008205
      - MGI:MGI:2443731
      - UniProtKB:Q7K6A4
      - SGD:S000004170
      - RGD:3050
      - FB:FBgn0005278
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-05-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-05-10'
      provided_by:
      - http://www.pombase.org
    term: GO:0006556
  has_output:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000316
      reference: PMID:10620770
      with_objects:
      - SGD:S000004170
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-05-10'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000239344
      - RGD:3050
      - PomBase:SPBC14F5.05c
      - TAIR:locus:2196160
      - UniProtKB:Q586F9
      - UniProtKB:Q586G3
      - RGD:619985
      - UniProtKB:P31153
      - UniProtKB:P0A817
      - SGD:S000004170
      - UniProtKB:Q586G1
      - MGI:MGI:2443731
      - TAIR:locus:2058011
      - UniProtKB:Q7K6A4
      - WB:WBGene00008205
      - UniProtKB:Q00266
      - SGD:S000002910
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-05-10'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000239344
      - RGD:3050
      - PomBase:SPBC14F5.05c
      - TAIR:locus:2196160
      - UniProtKB:Q586F9
      - UniProtKB:Q586G3
      - RGD:619985
      - UniProtKB:P31153
      - UniProtKB:P0A817
      - SGD:S000004170
      - UniProtKB:Q586G1
      - MGI:MGI:2443731
      - TAIR:locus:2058011
      - UniProtKB:Q7K6A4
      - WB:WBGene00008205
      - UniProtKB:Q00266
      - SGD:S000002910
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-05-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-05-10'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:59789
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000316
      reference: PMID:10620770
      with_objects:
      - SGD:S000004170
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-05-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-05-10'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:59789
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000316
      reference: PMID:10620770
      with_objects:
      - SGD:S000004170
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-05-10'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000239344
      - RGD:3050
      - PomBase:SPBC14F5.05c
      - TAIR:locus:2196160
      - UniProtKB:Q586F9
      - UniProtKB:Q586G3
      - RGD:619985
      - UniProtKB:P31153
      - UniProtKB:P0A817
      - SGD:S000004170
      - UniProtKB:Q586G1
      - MGI:MGI:2443731
      - TAIR:locus:2058011
      - UniProtKB:Q7K6A4
      - WB:WBGene00008205
      - UniProtKB:Q00266
      - SGD:S000002910
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-05-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-05-10'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:59789
- id: gomodel:67b1629100004168/67b1629100004357
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000168362
      - SGD:S000006273
      - UniProtKB:Q8II73
      - TAIR:locus:2016129
      - TAIR:locus:2034903
      - UniProtKB:P19623
      - RGD:620796
      - TAIR:locus:2163771
      - UniProtKB:Q9WZC2
      - UniProtKB:P09158
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC12C2.07c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004766
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000168362
      - UniProtKB:P09158
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000168362
      - TAIR:locus:2016129
      - UniProtKB:Q8II73
      - ZFIN:ZDB-GENE-040426-1183
      - UniProtKB:O25503
      - UniProtKB:G5EAU1
      - dictyBase:DDB_G0268630
      - UniProtKB:Q9WZC2
      - TAIR:locus:2034903
      - RGD:620796
      - UniProtKB:P19623
      - SGD:S000006273
      - UniProtKB:P09158
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: GO:0008295
  has_input:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000168362
      - SGD:S000006273
      - UniProtKB:Q8II73
      - TAIR:locus:2016129
      - TAIR:locus:2034903
      - UniProtKB:P19623
      - RGD:620796
      - TAIR:locus:2163771
      - UniProtKB:Q9WZC2
      - UniProtKB:P09158
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:57443
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000168362
      - SGD:S000006273
      - UniProtKB:Q8II73
      - TAIR:locus:2016129
      - TAIR:locus:2034903
      - UniProtKB:P19623
      - RGD:620796
      - TAIR:locus:2163771
      - UniProtKB:Q9WZC2
      - UniProtKB:P09158
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:57443
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:326268
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000168362
      - SGD:S000006273
      - UniProtKB:Q8II73
      - TAIR:locus:2016129
      - TAIR:locus:2034903
      - UniProtKB:P19623
      - RGD:620796
      - TAIR:locus:2163771
      - UniProtKB:Q9WZC2
      - UniProtKB:P09158
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000168362
      - SGD:S000006273
      - UniProtKB:Q8II73
      - TAIR:locus:2016129
      - TAIR:locus:2034903
      - UniProtKB:P19623
      - RGD:620796
      - TAIR:locus:2163771
      - UniProtKB:Q9WZC2
      - UniProtKB:P09158
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-02-27'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:326268
  has_output:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:17509
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-02-27'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:57834
objects:
- id: CHEBI:46911
  label: L-ornithinium(1+)
  type: gocam:Object
- id: GO:0004586
  label: ornithine decarboxylase activity
  type: gocam:Object
- id: PomBase:SPAC144.04c
  label: spe1 Spom
  type: gocam:Object
- id: GO:0033387
  label: putrescine biosynthetic process from arginine, via ornithine
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: GO:0004053
  label: arginase activity
  type: gocam:Object
- id: PomBase:SPBP26C9.02c
  label: car1 Spom
  type: gocam:Object
- id: GO:0000050
  label: urea cycle
  type: gocam:Object
- id: ECO:0000316
  label: genetic interaction evidence used in manual assertion
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:16467
  label: L-arginine
  type: gocam:Object
- id: CHEBI:16199
  label: urea
  type: gocam:Object
- id: CHEBI:326268
  label: 1,4-butanediammonium
  type: gocam:Object
- id: GO:0008073
  label: ornithine decarboxylase inhibitor activity
  type: gocam:Object
- id: PomBase:SPBC577.14c
  label: spa1 Spom
  type: gocam:Object
- id: GO:0004014
  label: adenosylmethionine decarboxylase activity
  type: gocam:Object
- id: PomBase:SPBP4H10.05c
  label: spe2 Spom
  type: gocam:Object
- id: GO:0008295
  label: spermidine biosynthetic process
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:59789
  label: S-adenosyl-L-methionine zwitterion
  type: gocam:Object
- id: CHEBI:57443
  label: S-adenosylmethioninaminium
  type: gocam:Object
- id: GO:0004766
  label: spermidine synthase activity
  type: gocam:Object
- id: PomBase:SPBC12C2.07c
  label: srm1 Spom
  type: gocam:Object
- id: CHEBI:17509
  label: 5'-S-methyl-5'-thioadenosine
  type: gocam:Object
- id: CHEBI:57834
  label: spermidine(3+)
  type: gocam:Object
- id: GO:0016768
  label: spermine synthase activity
  type: gocam:Object
- id: GO:0006597
  label: spermine biosynthetic process
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:45725
  label: spermine(4+)
  type: gocam:Object
- id: GO:1901305
  label: negative regulation of spermidine biosynthetic process
  type: gocam:Object
- id: ECO:0000303
  label: author statement without traceable support used in manual assertion
  type: gocam:Object
- id: GO:0004478
  label: methionine adenosyltransferase activity
  type: gocam:Object
- id: PomBase:SPBC14F5.05c
  label: sam1 Spom
  type: gocam:Object
- id: GO:0006556
  label: S-adenosylmethionine biosynthetic process
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  - https://orcid.org/0009-0003-9059-1333
  date: '2025-05-19'
  provided_by:
  - http://www.pombase.org
