id: gomodel:67c10cc400002026
title: biotin import across plasma membrane (GO:1905135),  biotin biosynthetic process
  (GO:0009102),  protein maturation (GO:0051604) - biotinylated proteins
taxon: NCBITaxon:4896
status: production
comments:
- These pathway holes are working on the assumption that the location of biotin synthase
  is correct, but this seems unlikely, especially since the substrates are both cytosolic.
  Maybe there is aun undiscovered biotinylated protein in the mitochondrion?
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      - UniProtKB:C6S3D7
      - RGD:1565360
      - CGD:CAL0000192734
      - FB:FBgn0037332
      - MGI:MGI:894646
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      provenances:
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      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:67c10cc400002026/67e5e74400000328
  - type: CausalAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000303161
      - UniProtKB:P50747
      - SGD:S000002300
      - UniProtKB:P06709
      - UniProtKB:C6S3D7
      - RGD:1565360
      - CGD:CAL0000192734
      - FB:FBgn0037332
      - MGI:MGI:894646
      - TAIR:locus:2050291
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-28'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000303161
      - UniProtKB:P50747
      - SGD:S000002300
      - UniProtKB:P06709
      - UniProtKB:C6S3D7
      - RGD:1565360
      - CGD:CAL0000192734
      - FB:FBgn0037332
      - MGI:MGI:894646
      - TAIR:locus:2050291
      provenances:
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        provided_by:
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      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:67c10cc400002026/67e5e74400000287
- id: gomodel:67c10cc400002026/67c10cc400002036
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000316
      reference: PMID:10525840
      with_objects:
      - SGD:S000003518
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-07'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000540961
      - TAIR:locus:2005497
      - PomBase:SPCC1235.02
      - SGD:S000003518
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      provenances:
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      date: '2025-03-07'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPCC1235.02
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0004076
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000316
      reference: PMID:10525840
      with_objects:
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      provenances:
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        provided_by:
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    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
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      provenances:
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    provenances:
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      date: '2025-03-07'
      provided_by:
      - http://www.pombase.org
    term: GO:0009102
  has_input:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000316
      reference: PMID:10525840
      with_objects:
      - SGD:S000003518
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-07'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000540961
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      provenances:
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        provided_by:
        - http://www.pombase.org
    - term: ECO:0000316
      reference: PMID:10525840
      with_objects:
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      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-07'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000540961
      - TAIR:locus:2005497
      - PomBase:SPCC1235.02
      - SGD:S000003518
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      provenances:
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        date: '2025-03-07'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-07'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:149473
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000316
      reference: PMID:10525840
      with_objects:
      - SGD:S000003518
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-07'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000540961
      - TAIR:locus:2005497
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      - SGD:S000003518
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      provenances:
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        provided_by:
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    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-07'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:149473
  has_output:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000316
      reference: PMID:10525840
      with_objects:
      - SGD:S000003518
      provenances:
      - contributor:
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        date: '2025-03-28'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000540961
      - TAIR:locus:2005497
      - PomBase:SPCC1235.02
      - SGD:S000003518
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      provenances:
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        date: '2025-03-28'
        provided_by:
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    provenances:
    - contributor:
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      date: '2025-03-28'
      provided_by:
      - http://www.pombase.org
    term: CHEBI:15956
objects:
- id: GO:0004076
  label: biotin synthase activity
  type: gocam:Object
- id: PomBase:SPCC1235.02
  label: bio2 Spom
  type: gocam:Object
- id: GO:0009102
  label: biotin biosynthetic process
  type: gocam:Object
- id: ECO:0000316
  label: genetic interaction evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: GO:1901604
  label: dethiobiotin transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPAC1B3.16c
  label: vht1 Spom
  type: gocam:Object
- id: GO:1905136
  label: dethiobiotin import across plasma membrane
  type: gocam:Object
- id: GO:0005886
  label: plasma membrane
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:16691
  label: dethiobiotin
  type: gocam:Object
- id: CHEBI:149473
  label: (4R,5S)-dethiobiotin(1-)
  type: gocam:Object
- id: GO:0005576
  label: extracellular region
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: GO:0015225
  label: biotin transmembrane transporter activity
  type: gocam:Object
- id: GO:1905135
  label: biotin import across plasma membrane
  type: gocam:Object
- id: CHEBI:15956
  label: biotin
  type: gocam:Object
- id: GO:0004077
  label: biotin--[biotin carboxyl-carrier protein] ligase activity
  type: gocam:Object
- id: PomBase:SPBC30D10.07c
  label: bpl1 Spom
  type: gocam:Object
- id: GO:0051604
  label: protein maturation
  type: gocam:Object
- id: ECO:0000303
  label: author statement without traceable support used in manual assertion
  type: gocam:Object
- id: GO:0022857
  label: transmembrane transporter activity
  type: gocam:Object
- id: CHEBI:36080
  label: protein
  type: gocam:Object
- id: GO:0031966
  label: mitochondrial membrane
  type: gocam:Object
- id: GO:0005739
  label: mitochondrion
  type: gocam:Object
- id: PomBase:SPAC56E4.04c
  label: cut6 Spom
  type: gocam:Object
- id: GO:2001295
  label: malonyl-CoA biosynthetic process
  type: gocam:Object
- id: CHEBI:81472
  label: Biotinyl-[protein]
  type: gocam:Object
- id: GO:0003989
  label: acetyl-CoA carboxylase activity
  type: gocam:Object
- id: GO:0006633
  label: fatty acid biosynthetic process
  type: gocam:Object
- id: ECO:0000501
  label: evidence used in automatic assertion
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0004736
  label: pyruvate carboxylase activity
  type: gocam:Object
- id: PomBase:SPBC17G9.11c
  label: pyr1 Spom
  type: gocam:Object
- id: GO:0006090
  label: pyruvate metabolic process
  type: gocam:Object
- id: CHEBI:57288
  label: acetyl-CoA(4-)
  type: gocam:Object
- id: CHEBI:57384
  label: malonyl-CoA(5-)
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  - https://orcid.org/0009-0003-9059-1333
  date: '2025-07-23'
  provided_by:
  - http://www.pombase.org
