id: gomodel:6690711d00001545
title: 'L-serine biosynthetic process (GO:0006564), cysteine biosynthetic process
  from serine (GO:0006535)

  '
taxon: NCBITaxon:4896
status: production
comments:
- 'basic pathway https://www.researchgate.net/publication/6852717_A_Peroxisomal_Glutathione_Transferase_of_Saccharomyces_cerevisiae_Is_Functionally_Related_to_Sulfur_Amino_Acid_Metabolism/figures?lo=1

  '
- 'see https://github.com/geneontology/go-ontology/issues/28833 foir an explanation
  of the alternative cysteine synthase specificity/inputs

  '
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    term: CHEBI:18110
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    term: CHEBI:29985
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    term: CHEBI:16810
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    term: PomBase:SPBC3H7.07c
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    term: CHEBI:17115
objects:
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  label: author statement without traceable support used in manual assertion
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  label: phosphoglycerate dehydrogenase activity
  type: gocam:Object
- id: PomBase:SPCC364.07
  label: ser3 Spom
  type: gocam:Object
- id: GO:0006564
  label: L-serine biosynthetic process
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
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  label: O-phospho-L-serine:2-oxoglutarate aminotransferase activity
  type: gocam:Object
- id: PomBase:SPAC1F12.07
  label: ser1 Spom
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: GO:0036424
  label: L-phosphoserine phosphatase activity
  type: gocam:Object
- id: PomBase:SPBC3H7.07c
  label: ser2 Spom
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: CHEBI:17115
  label: L-serine
  type: gocam:Object
- id: CHEBI:58272
  label: 3-phosphonato-D-glycerate(3-)
  type: gocam:Object
- id: GO:0004619
  label: phosphoglycerate mutase activity
  type: gocam:Object
- id: PomBase:SPAC26F1.06
  label: gpm1 Spom
  type: gocam:Object
- id: GO:0061621
  label: canonical glycolysis
  type: gocam:Object
- id: ECO:0000316
  label: genetic interaction evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: GO:0015194
  label: L-serine transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPAC17G6.15c
  label: fsf1 Spom
  type: gocam:Object
- id: GO:0140300
  label: serine import into mitochondrion
  type: gocam:Object
- id: GO:0005743
  label: mitochondrial inner membrane
  type: gocam:Object
- id: GO:0005739
  label: mitochondrion
  type: gocam:Object
- id: CHEBI:16810
  label: 2-oxoglutarate(2-)
  type: gocam:Object
- id: CHEBI:57524
  label: O-phosphonato-L-serine(2-)
  type: gocam:Object
- id: CHEBI:58289
  label: 2-phosphonato-D-glycerate(3-)
  type: gocam:Object
- id: CHEBI:18110
  label: 3-phosphonatooxypyruvate(3-)
  type: gocam:Object
- id: GO:0004828
  label: serine-tRNA ligase activity
  type: gocam:Object
- id: PomBase:SPAC25B8.06c
  label: dia4 Spom
  type: gocam:Object
- id: GO:0043038
  label: amino acid activation
  type: gocam:Object
- id: GO:0005759
  label: mitochondrial matrix
  type: gocam:Object
- id: GO:0004817
  label: cysteine-tRNA ligase activity
  type: gocam:Object
- id: PomBase:SPAC29E6.06c
  label: SPAC29E6.06c Spom
  type: gocam:Object
- id: CHEBI:29985
  label: L-glutamate(1-)
  type: gocam:Object
- id: CHEBI:29152
  label: Cys-tRNA(Cys)
  type: gocam:Object
- id: PomBase:SPMITTRNACYS.01
  label: SPMITTRNACYS.01 Spom
  type: gocam:Object
- id: CHEBI:29162
  label: Ser-tRNA(Ser)
  type: gocam:Object
- id: PomBase:SPMITTRNASER.02
  label: SPMITTRNASER.02 Spom
  type: gocam:Object
- id: GO:0004124
  label: cysteine synthase activity
  type: gocam:Object
- id: PomBase:SPBC36.04
  label: cys11 Spom
  type: gocam:Object
- id: GO:0006535
  label: cysteine biosynthetic process from serine
  type: gocam:Object
- id: GO:0160210
  label: L-serine O-succinyltransferase activity
  type: gocam:Object
- id: PomBase:SPBC106.17c
  label: cys2 Spom
  type: gocam:Object
- id: CHEBI:134286
  label: O-succinyl-L-serine
  type: gocam:Object
- id: CHEBI:16136
  label: hydrogen sulfide
  type: gocam:Object
- id: CHEBI:35235
  label: L-cysteine zwitterion
  type: gocam:Object
- id: CHEBI:26806
  label: succinate
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  date: '2025-04-23'
  provided_by:
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