# genes

id: YOR093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00982":null,"SJAG_03731":null,"YOR093C":null},"has_protein_features":false,"name":"CMR2","ortholog_annotations":[{"gene_uniquename":"YOR093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00982","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03731","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR093C"}


id: YOR094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01456":null,"YOR094W":null},"has_protein_features":false,"name":"ARF3","ortholog_annotations":[{"gene_uniquename":"YOR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01456","reference_uniquename":"PMID:29761456"}],"product":"Glucose-repressible ADP-ribosylation factor; GTPase of Ras superfamily involved in regulating cell polarity and invasive growth; localizes to dynamic spots at plasma membrane and modulates PtdIns(4,5)P2 levels to facilitate endocytosis; required for localization of endocytic protein Lsb5p to correct cortical site in cells; also has mRNA binding activity; homolog of mammalian Arf6","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005620","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR094W"}


id: YOR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00070":null,"YOR095C":null},"has_protein_features":false,"name":"RKI1","ortholog_annotations":[{"gene_uniquename":"YOR095C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00070","reference_uniquename":"PMID:29761456"}],"product":"Ribose-5-phosphate ketol-isomerase; catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005621","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR095C"}


id: YOR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02046":null,"YOR096W":null},"has_protein_features":false,"name":"RPS7A","ortholog_annotations":[{"gene_uniquename":"YOR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02046","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005622","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR096W"}


id: YOR097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene","secondary_identifier":"SGD:S000005623","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR097C"}


id: YOR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03729":null,"YOR098C":null},"has_protein_features":false,"name":"NUP1","ortholog_annotations":[{"gene_uniquename":"YOR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03729","reference_uniquename":"PMID:29761456"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of thenuclear pore complex (NPC) permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005624","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR098C"}


id: YOR099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"YOR099W":null},"has_protein_features":false,"name":"KTR1","ortholog_annotations":[{"gene_uniquename":"YOR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"}],"product":"Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005625","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR099W"}


id: YOR100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00543":null,"YOR100C":null},"has_protein_features":false,"name":"CRC1","ortholog_annotations":[{"gene_uniquename":"YOR100C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00543","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homolog SLC25A20 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR100C"}


id: YOR101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03453":null,"YOR101W":null},"has_protein_features":false,"name":"RAS1","ortholog_annotations":[{"gene_uniquename":"YOR101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03453","reference_uniquename":"PMID:29761456"}],"product":"GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in regulation of cell proliferation; localized to the plasma membrane; activated by increased levels of glycolysis intermediate fructose-1,6-bisphosphate; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress; RAS1 has a paralog, RAS2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR101W"}


id: YOR102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex","secondary_identifier":"SGD:S000005628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR102W"}


id: YOR103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01389":null,"YOR103C":null},"has_protein_features":false,"name":"OST2","ortholog_annotations":[{"gene_uniquename":"YOR103C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01389","reference_uniquename":"PMID:29761456"}],"product":"Epsilon subunit of the oligosaccharyltransferase complex; located in the ER lumen; catalyzes asparagine-linked glycosylation of newly synthesized proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR103C"}


id: YOR104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PIN2","product":"Exomer-dependent cargo protein; induces appearance of [PIN+] prion when overproduced; prion-like domain serves as a retention signal in the trans-Golgi network; predicted to be palmitoylated","secondary_identifier":"SGD:S000005630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR104W"}


id: YOR105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels","secondary_identifier":"SGD:S000005631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR105W"}


id: YOR106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"VAM3","product":"Syntaxin-like vacuolar t-SNARE; functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region","secondary_identifier":"SGD:S000005632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR106W"}


id: YOR107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RGS2","product":"Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p","secondary_identifier":"SGD:S000005633","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR107W"}


id: YOR108C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028711","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR108C-A"}


id: YOR108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02841":null,"YOR108W":null},"has_protein_features":false,"name":"LEU9","ortholog_annotations":[{"gene_uniquename":"YOR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02841","reference_uniquename":"PMID:29761456"}],"product":"Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005634","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR108W"}


id: YOR109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00063":null,"SJAG_03375":null,"YOR109W":null},"has_protein_features":false,"name":"INP53","ortholog_annotations":[{"gene_uniquename":"YOR109W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00063","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR109W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03375","reference_uniquename":"PMID:29761456"}],"product":"Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; INP53 has a paralog, INP52, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005635","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR109W"}


id: YOR110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05339":null,"YOR110W":null},"has_protein_features":false,"name":"TFC7","ortholog_annotations":[{"gene_uniquename":"YOR110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05339","reference_uniquename":"PMID:29761456"}],"product":"RNA pol III transcription initiation factor complex (TFIIIC) subunit; part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; TFC7 has a paralog, YNL108C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005636","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR110W"}


id: YOR111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01651":null,"YOR111W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01651","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005637","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR111W"}


id: YOR112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04622":null,"YOR112W":null},"has_protein_features":false,"name":"CEX1","ortholog_annotations":[{"gene_uniquename":"YOR112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04622","reference_uniquename":"PMID:29761456"}],"product":"Component of nuclear aminoacylation-dependent tRNA export pathway; cytoplasmic; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a; required for activation of RAN GTPase Gsp1p and dissociation of receptor-tRNA-Gsp1p export complex; recruits Rna1p from cytoplasm to NPC, facilitates Rna1p activation of Gsp1p GTPase activity by enabling Rna1p to gain access to Gsp1p-GTP bound to export receptor tRNA complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR112W"}


id: YOR113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AZF1","product":"Zinc-finger transcription factor; involved in the diauxic shift; activates transcription of genes involved in carbon metabolism and energy production on glucose, while it activates transcription of genes involved in cell wall organization and biogenesis on glycerol-lactate; may also function as a co-repressor; capable of forming the prion [AZF1+]; relocalizes to the cytosol in response to hypoxia; contains polyglutamine and polyasparagine domains","secondary_identifier":"SGD:S000005639","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR113W"}


id: YOR114W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DPI34","product":"Putative mitochondrial protein of unknown function; null mutant is viable","secondary_identifier":"SGD:S000005640","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR114W"}


id: YOR115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02525":null,"YOR115C":null},"has_protein_features":false,"name":"TRS33","ortholog_annotations":[{"gene_uniquename":"YOR115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02525","reference_uniquename":"PMID:29761456"}],"product":"Core component of TRAPP complexes I, II and IV; transport protein particle (TRAPP) complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII, and IV); proposed subunit of a novel complex, TRAPPIV, that may function redundantly with TRAPPIII as a GEF that activates Ypt1 during autophagy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005641","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR115C"}


id: YOR116C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04934":null,"YOR116C":null},"has_protein_features":false,"name":"RPO31","ortholog_annotations":[{"gene_uniquename":"YOR116C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04934","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase III largest subunit C160; part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR116C"}


id: YOR117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01544":null,"YOR117W":null},"has_protein_features":false,"name":"RPT5","ortholog_annotations":[{"gene_uniquename":"YOR117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01544","reference_uniquename":"PMID:29761456"}],"product":"ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR117W"}


id: YOR118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03620":null,"YOR118W":null},"has_protein_features":false,"name":"RTC5","ortholog_annotations":[{"gene_uniquename":"YOR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03620","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR118W"}


id: YOR119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05018":null,"YOR119C":null},"has_protein_features":false,"name":"RIO1","ortholog_annotations":[{"gene_uniquename":"YOR119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05018","reference_uniquename":"PMID:29761456"}],"product":"Serine kinase involved in cell cycle regulation and rDNA integrity; associated with late pre-40S particles via its conserved C-terminal domain; prevents premature use of pre-40S particles in translation; association with pre-40S particles regulated by its catalytic ATPase site and likely occurs after the release of Rio2p from these particles; involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA; phosphorylates Rpa43p in anaphase to remove Pol I from rDNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR119C"}


id: YOR120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02010":null,"YOR120W":null},"has_protein_features":false,"name":"GCY1","ortholog_annotations":[{"gene_uniquename":"YOR120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02010","reference_uniquename":"PMID:29761456"}],"product":"Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; human homolog AKR1B1 can complement yeast null mutant; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR120W"}


id: YOR121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W","secondary_identifier":"SGD:S000005647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR121C"}


id: YOR122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04982":null,"YOR122C":null},"has_protein_features":false,"name":"PFY1","ortholog_annotations":[{"gene_uniquename":"YOR122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04982","reference_uniquename":"PMID:29761456"}],"product":"Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress; highly conserved protein; human PFN1 (profilin 1) complements temperature sensitive pfy1 mutants, PFN1 mutations are a rare cause of ALS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005648","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR122C"}


id: YOR123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03118":null,"YOR123C":null},"has_protein_features":false,"name":"LEO1","ortholog_annotations":[{"gene_uniquename":"YOR123C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03118","reference_uniquename":"PMID:29761456"}],"product":"Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005649","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR123C"}


id: YOR124C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01528":null,"YOR124C":null},"has_protein_features":false,"name":"UBP2","ortholog_annotations":[{"gene_uniquename":"YOR124C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01528","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; controls K63 homeostasis during oxidative stress; deubiquitinates Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005650","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR124C"}


id: YOR125C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00459":null,"YOR125C":null},"has_protein_features":false,"name":"CAT5","ortholog_annotations":[{"gene_uniquename":"YOR125C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00459","reference_uniquename":"PMID:29761456"}],"product":"Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR125C"}


id: YOR126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01989":null,"YOR126C":null},"has_protein_features":false,"name":"IAH1","ortholog_annotations":[{"gene_uniquename":"YOR126C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01989","reference_uniquename":"PMID:29761456"}],"product":"Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR126C"}


id: YOR127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04522":null,"SJAG_04765":null,"YOR127W":null},"has_protein_features":false,"name":"RGA1","ortholog_annotations":[{"gene_uniquename":"YOR127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04522","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04765","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP); required for proper bud site selection; transiently localizes to previous cell division sites (bud scars; cytokinesis remnants), interacting with Nis1p and Nba1p, to prevent Cdc42p repolarization; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from the bud neck to cytoplasm upon DNA replication stress; contains N-terminal LIM domains and a C-terminal GAP domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005653","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR127W"}


id: YOR128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01081":null,"YOR128C":null},"has_protein_features":false,"name":"ADE2","ortholog_annotations":[{"gene_uniquename":"YOR128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01081","reference_uniquename":"PMID:29761456"}],"product":"Phosphoribosylaminoimidazole carboxylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005654","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR128C"}


id: YOR129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AFI1","product":"Arf3p polarization-specific docking factor; required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p","secondary_identifier":"SGD:S000005655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR129C"}


id: YOR130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00543":null,"YOR130C":null},"has_protein_features":false,"name":"ORT1","ortholog_annotations":[{"gene_uniquename":"YOR130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00543","reference_uniquename":"PMID:29761456"}],"product":"Ornithine transporter of the mitochondrial inner membrane; exports ornithine from mitochondria as part of arginine biosynthesis; functionally complemented by human ortholog, SLC25A15, which is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome, but HHH-associated variants fail to complement","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR130C"}


id: YOR131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000005657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR131C"}


id: YOR132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00971":null,"YOR132W":null},"has_protein_features":false,"name":"VPS17","ortholog_annotations":[{"gene_uniquename":"YOR132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00971","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the membrane-associated retromer complex; essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR132W"}


id: YOR133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01438":null,"SJAG_05332":null,"YOR133W":null},"has_protein_features":false,"name":"EFT1","ortholog_annotations":[{"gene_uniquename":"YOR133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01438","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05332","reference_uniquename":"PMID:29761456"}],"product":"Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR133W"}


id: YOR134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04462":null,"YOR134W":null},"has_protein_features":false,"name":"BAG7","ortholog_annotations":[{"gene_uniquename":"YOR134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04462","reference_uniquename":"PMID:29761456"}],"product":"Rho GTPase activating protein (RhoGAP); stimulates the intrinsic GTPase activity of Rho1p, which plays a bud growth by regulating actin cytoskeleton organization and cell wall biosynthesis, resulting in the downregulation of Rho1p; structurally and functionally related to Sac7p; BAG7 has a paralog, SAC7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR134W"}


id: YOR135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IRC14","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci","secondary_identifier":"SGD:S000005661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR135C"}


id: YOR136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IDH2","product":"Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated","secondary_identifier":"SGD:S000005662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR136W"}


id: YOR137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04262":null,"YOR137C":null},"has_protein_features":false,"name":"SIA1","ortholog_annotations":[{"gene_uniquename":"YOR137C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04262","reference_uniquename":"PMID:29761456"}],"product":"Protein of unassigned function; involved in activation of the Pma1p plasma membrane H+-ATPase by glucose; contains peptide signal for membrane localization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005663","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR137C"}


id: YOR138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01342":null,"YOR138C":null},"has_protein_features":false,"name":"RUP1","ortholog_annotations":[{"gene_uniquename":"YOR138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01342","reference_uniquename":"PMID:29761456"}],"product":"Protein that regulates ubiquitination of Rsp5p; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005664","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR138C"}


id: YOR139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W","secondary_identifier":"SGD:S000005665","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR139C"}


id: YOR140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02472":null,"SJAG_04388":null,"YOR140W":null},"has_protein_features":false,"name":"SFL1","ortholog_annotations":[{"gene_uniquename":"YOR140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02472","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04388","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; has direct role in INO1 transcriptional memory; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p; premature stop codon (C1430T, Q477-stop) in SK1 background is linked to the aggressively invasive phenotype of SK1 relative to BY4741 (S288C)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005666","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR140W"}


id: YOR141C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01611":null,"YOR141C":null},"has_protein_features":false,"name":"ARP8","ortholog_annotations":[{"gene_uniquename":"YOR141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01611","reference_uniquename":"PMID:29761456"}],"product":"Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; has mRNA binding activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005667","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR141C"}


id: YOR142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01524":null,"YOR142W":null},"has_protein_features":false,"name":"LSC1","ortholog_annotations":[{"gene_uniquename":"YOR142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01524","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005668","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR142W"}


id: YOR143C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03362":null,"YOR143C":null},"has_protein_features":false,"name":"THI80","ortholog_annotations":[{"gene_uniquename":"YOR143C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03362","reference_uniquename":"PMID:29761456"}],"product":"Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR143C"}


id: YOR144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04150":null,"YOR144C":null},"has_protein_features":false,"name":"ELG1","ortholog_annotations":[{"gene_uniquename":"YOR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04150","reference_uniquename":"PMID:29761456"}],"product":"Subunit of an alternative replication factor C complex; important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005670","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR144C"}


id: YOR145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03872":null,"YOR145C":null},"has_protein_features":false,"name":"PNO1","ortholog_annotations":[{"gene_uniquename":"YOR145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03872","reference_uniquename":"PMID:29761456"}],"product":"Essential nucleolar protein required for pre-18S rRNA processing; interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR145C"}


id: YOR146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C","secondary_identifier":"SGD:S000005672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR146W"}


id: YOR147W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03395":null,"YOR147W":null},"has_protein_features":false,"name":"MDM32","ortholog_annotations":[{"gene_uniquename":"YOR147W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03395","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein with similarity to Mdm31p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34; variation between SK1 and S288C at residues 182 and 262 impacts invasive growth and mitochondrial network structure","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR147W"}


id: YOR148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01557":null,"YOR148C":null},"has_protein_features":false,"name":"SPP2","ortholog_annotations":[{"gene_uniquename":"YOR148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01557","reference_uniquename":"PMID:29761456"}],"product":"Essential protein that promotes the first step of splicing; required for the final stages of spliceosome maturation and activation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction; stimulates Prp2p ATPase activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005674","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR148C"}


id: YOR149C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03878":null,"YOR149C":null},"has_protein_features":false,"name":"SMP3","ortholog_annotations":[{"gene_uniquename":"YOR149C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03878","reference_uniquename":"PMID:29761456"}],"product":"Alpha 1,2-mannosyltransferase; involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005675","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR149C"}


id: YOR150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03176":null,"YOR150W":null},"has_protein_features":false,"name":"MRPL23","ortholog_annotations":[{"gene_uniquename":"YOR150W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03176","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR150W"}


id: YOR151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04030":null,"YOR151C":null},"has_protein_features":false,"name":"RPB2","ortholog_annotations":[{"gene_uniquename":"YOR151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04030","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR151C"}


id: YOR152C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATG40","product":"Autophagy receptor with a role in endoplasmic reticulum degradation; involved specifically in autophagy of cortical and cytoplasmic ER in response to nitrogen starvation or rapamycin treatment; acts with COPII subunit Sfb3p; localizes to the cortical and cytoplasmic ER; similar to human FAM134B, which is also involved in ER autophagy and is associated with sensory neuropathy","secondary_identifier":"SGD:S000005678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR152C"}


id: YOR153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04277":null,"YOR153W":null},"has_protein_features":false,"name":"PDR5","ortholog_annotations":[{"gene_uniquename":"YOR153W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth; PDR5 has a paralog, PDR15, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005679","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR153W"}


id: YOR154W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02032":null,"YOR154W":null},"has_protein_features":false,"name":"SLP1","ortholog_annotations":[{"gene_uniquename":"YOR154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02032","reference_uniquename":"PMID:29761456"}],"product":"Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005680","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR154W"}


id: YOR155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03096":null,"YOR155C":null},"has_protein_features":false,"name":"ISN1","ortholog_annotations":[{"gene_uniquename":"YOR155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03096","reference_uniquename":"PMID:29761456"}],"product":"Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase; catalyzes the breakdown of IMP to inosine; responsible for production of nicotinamide riboside and nicotinic acid riboside; expression positively regulated by nicotinic acid and glucose availability; does not show similarity to known 5'-nucleotidases from other organisms","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005681","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR155C"}


id: YOR156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00727":null,"YOR156C":null},"has_protein_features":false,"name":"NFI1","ortholog_annotations":[{"gene_uniquename":"YOR156C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00727","reference_uniquename":"PMID:29761456"}],"product":"SUMO E3 ligase; catalyzes sumoylation of Yku70p/80p and Sir4p promoting telomere anchoring to the nuclear envelope and regulating telomerase activity; DNA-bound form catalyzes a DNA-damaged triggered sumoylation wave resulting in multisite modification of several DNA repair proteins, enhancing interactions between these proteins and accelerating repair; sumoylates Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; role in telomere length maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005682","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR156C"}


id: YOR157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01014":null,"YOR157C":null},"has_protein_features":false,"name":"PUP1","ortholog_annotations":[{"gene_uniquename":"YOR157C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01014","reference_uniquename":"PMID:29761456"}],"product":"Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005683","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR157C"}


id: YOR158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00148":null,"YOR158W":null},"has_protein_features":false,"name":"PET123","ortholog_annotations":[{"gene_uniquename":"YOR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00148","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR158W"}


id: YOR159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03469":null,"YOR159C":null},"has_protein_features":false,"name":"SME1","ortholog_annotations":[{"gene_uniquename":"YOR159C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03469","reference_uniquename":"PMID:29761456"}],"product":"Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005685","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR159C"}


id: YOR160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03470":null,"YOR160W":null},"has_protein_features":false,"name":"MTR10","ortholog_annotations":[{"gene_uniquename":"YOR160W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03470","reference_uniquename":"PMID:29761456"}],"product":"Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005686","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR160W"}


id: YOR161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00763":null,"YOR161C":null},"has_protein_features":false,"name":"PNS1","ortholog_annotations":[{"gene_uniquename":"YOR161C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00763","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005687","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR161C"}


id: YOR161C-C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028712","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR161C-C"}


id: YOR161W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028713","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR161W-A"}


id: YOR161W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028714","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR161W-B"}


id: YOR162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YRR1","product":"Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005688","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR162C"}


id: YOR163W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04870":null,"YOR163W":null},"has_protein_features":false,"name":"DDP1","ortholog_annotations":[{"gene_uniquename":"YOR163W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04870","reference_uniquename":"PMID:29761456"}],"product":"Diadenosine and diphosphoinositol polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005689","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR163W"}


id: YOR164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03865":null,"YOR164C":null},"has_protein_features":false,"name":"GET4","ortholog_annotations":[{"gene_uniquename":"YOR164C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03865","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005690","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR164C"}


id: YOR165W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02595":null,"YOR165W":null},"has_protein_features":false,"name":"SEY1","ortholog_annotations":[{"gene_uniquename":"YOR165W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02595","reference_uniquename":"PMID:29761456"}],"product":"Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005691","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR165W"}


id: YOR166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04198":null,"YOR166C":null},"has_protein_features":false,"name":"SWT1","ortholog_annotations":[{"gene_uniquename":"YOR166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04198","reference_uniquename":"PMID:29761456"}],"product":"RNA endoribonuclease involved in perinuclear mRNP quality control; involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005692","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR166C"}


id: YOR167C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02749":null,"SJAG_04746":null,"YOR167C":null},"has_protein_features":false,"name":"RPS28A","ortholog_annotations":[{"gene_uniquename":"YOR167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02749","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04746","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; has an extraribosomal function in regulation of RPS28B, in which Rps28Ap binds to a decapping complex via Edc3p, which then binds to RPS28B mRNA leading to its decapping and degradation; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28A has a paralog, RPS28B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005693","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR167C"}


id: YOR168W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04482":null,"YOR168W":null},"has_protein_features":false,"name":"GLN4","ortholog_annotations":[{"gene_uniquename":"YOR168W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04482","reference_uniquename":"PMID:29761456"}],"product":"Glutamine tRNA synthetase; monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Gln); N-terminal domain proposed to be involved in enzyme-tRNA interactions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005694","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR168W"}


id: YOR169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W","secondary_identifier":"SGD:S000005695","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR169C"}


id: YOR170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4","secondary_identifier":"SGD:S000005696","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR170W"}


id: YOR171C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02429":null,"YOR171C":null},"has_protein_features":false,"name":"LCB4","ortholog_annotations":[{"gene_uniquename":"YOR171C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02429","reference_uniquename":"PMID:29761456"}],"product":"Sphingoid long-chain base kinase; responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes; LCB4 has a paralog, LCB5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005697","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR171C"}


id: YOR172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YRM1","product":"Zinc finger transcription factor involved in multidrug resistance; Zn(2)-Cys(6) zinc finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes","secondary_identifier":"SGD:S000005698","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR172W"}


id: YOR173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01625":null,"YOR173W":null},"has_protein_features":false,"name":"DCS2","ortholog_annotations":[{"gene_uniquename":"YOR173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01625","reference_uniquename":"PMID:29761456"}],"product":"m(7)GpppX pyrophosphatase regulator; non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance; DCS2 has a paralog, DCS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005699","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR173W"}


id: YOR174W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00297":null,"YOR174W":null},"has_protein_features":false,"name":"MED4","ortholog_annotations":[{"gene_uniquename":"YOR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00297","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005700","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR174W"}


id: YOR175C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04792":null,"YOR175C":null},"has_protein_features":false,"name":"ALE1","ortholog_annotations":[{"gene_uniquename":"YOR175C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04792","reference_uniquename":"PMID:29761456"}],"product":"Broad-specificity lysophospholipid acyltransferase; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005701","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR175C"}


id: YOR176W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01841":null,"YOR176W":null},"has_protein_features":false,"name":"HEM15","ortholog_annotations":[{"gene_uniquename":"YOR176W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01841","reference_uniquename":"PMID:29761456"}],"product":"Ferrochelatase; a mitochondrial inner membrane protein, catalyzes insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; human homolog FECH can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005702","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR176W"}


id: YOR177C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MPC54","product":"Component of the meiotic outer plaque; a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate","secondary_identifier":"SGD:S000005703","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR177C"}


id: YOR178C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GAC1","product":"Regulatory subunit for Glc7p type-1 protein phosphatase (PP1); tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock; GAC1 has a paralog, PIG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR178C"}


id: YOR179C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SYC1","product":"Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005705","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR179C"}


id: YOR180C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DCI1","product":"Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed; DCI1 has a paralog, ECI1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005706","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR180C"}


id: YOR181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01732":null,"YOR181W":null},"has_protein_features":false,"name":"LAS17","ortholog_annotations":[{"gene_uniquename":"YOR181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01732","reference_uniquename":"PMID:29761456"}],"product":"Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments, polyproline domain nucleates actin filaments independent of Arp2/3; mutants are defective in endocytosis, bud site selection, cytokinesis; human homolog WAS (Wiskott-Aldrich Syndrome) implicated in severe immunodeficiency; human WAS complements yeast null mutant, but only in presence of WIPF1, which mediates localization of WAS to cortical patches","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005707","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR181W"}


id: YOR182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01287":null,"SJAG_02224":null,"YOR182C":null},"has_protein_features":false,"name":"RPS30B","ortholog_annotations":[{"gene_uniquename":"YOR182C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01287","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR182C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02224","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30B has a paralog, RPS30A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005708","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR182C"}


id: YOR183W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FYV12","product":"Protein of unknown function; required for survival upon exposure to K1 killer toxin","secondary_identifier":"SGD:S000005709","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR183W"}


id: YOR184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02791":null,"YOR184W":null},"has_protein_features":false,"name":"SER1","ortholog_annotations":[{"gene_uniquename":"YOR184W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02791","reference_uniquename":"PMID:29761456"}],"product":"3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005710","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR184W"}


id: YOR185C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01449":null,"YOR185C":null},"has_protein_features":false,"name":"GSP2","ortholog_annotations":[{"gene_uniquename":"YOR185C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01449","reference_uniquename":"PMID:29761456"}],"product":"GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); not required for viability; protein abundance increases in response to DNA replication stress; GSP2 has a paralog, GSP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005711","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR185C"}


id: YOR186C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028715","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR186C-A"}


id: YOR186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; mCherry fusion protein localizes to the vacuole; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005712","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR186W"}


id: YOR187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03461":null,"YOR187W":null},"has_protein_features":false,"name":"TUF1","ortholog_annotations":[{"gene_uniquename":"YOR187W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03461","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial translation elongation factor Tu (EF-Tu); involved in fundamental pathway of mtDNA homeostasis; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans; rare mutations in human mitochondrial elongation factor Tu (EFTu) associated with severe lactic acidosis, rapidly progressive fatal encephalopathy, severe infantile macrocystic leukodystrophy with micropolygyria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005713","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR187W"}


id: YOR188W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05004":null,"YOR188W":null},"has_protein_features":false,"name":"MSB1","ortholog_annotations":[{"gene_uniquename":"YOR188W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05004","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005714","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR188W"}


id: YOR189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00746":null,"YOR189W":null},"has_protein_features":false,"name":"IES4","ortholog_annotations":[{"gene_uniquename":"YOR189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00746","reference_uniquename":"PMID:29761456"}],"product":"Component of the INO80 chromatiin remodeling complex; target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005715","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR189W"}


id: YOR190W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01171":null,"SJAG_01888":null,"SJAG_05001":null,"YOR190W":null},"has_protein_features":false,"name":"SPR1","ortholog_annotations":[{"gene_uniquename":"YOR190W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01171","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR190W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01888","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR190W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05001","reference_uniquename":"PMID:29761456"}],"product":"Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance; SPR1 has a paralog, EXG1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005716","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR190W"}


id: YOR191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00475":null,"SJAG_02575":null,"YOR191W":null},"has_protein_features":false,"name":"ULS1","ortholog_annotations":[{"gene_uniquename":"YOR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00475","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02575","reference_uniquename":"PMID:29761456"}],"product":"Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL); required for maintenance of NHEJ inhibition at telomeres; functions at telomeres to translocate and ubiquitinylate poly-sumoylated Rap1p for proteosomal degradation; plays role in antagonizing silencing during mating-type switching; only known STUbL with a translocase activity; contains RING finger domain; relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005717","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR191W"}


id: YOR192C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"THI72","product":"Transporter of thiamine or related compound; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); shares sequence similarity with Thi7p","secondary_identifier":"SGD:S000005718","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR192C"}


id: YOR192C-C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028857","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR192C-C"}


id: YOR193W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEX27","product":"Peripheral peroxisomal membrane protein; involved in controlling peroxisome size and number, interacts with Pex25p; PEX27 has a paralog, PEX25, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005719","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR193W"}


id: YOR194C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01710":null,"YOR194C":null},"has_protein_features":false,"name":"TOA1","ortholog_annotations":[{"gene_uniquename":"YOR194C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01710","reference_uniquename":"PMID:29761456"}],"product":"TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa2p, for ribosomal protein gene transcription in vivo; homologous to largest and second largest subunits of human and Drosophila TFIIA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005720","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR194C"}


id: YOR195W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02761":null,"YOR195W":null},"has_protein_features":false,"name":"SLK19","ortholog_annotations":[{"gene_uniquename":"YOR195W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02761","reference_uniquename":"PMID:29761456"}],"product":"Kinetochore-associated protein; required for chromosome segregation and kinetochore clustering; required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005721","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR195W"}


id: YOR196C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03553":null,"YOR196C":null},"has_protein_features":false,"name":"LIP5","ortholog_annotations":[{"gene_uniquename":"YOR196C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03553","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in biosynthesis of the coenzyme lipoic acid; has similarity to E. coli lipoic acid synthase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005722","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR196C"}


id: YOR197W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00135":null,"YOR197W":null},"has_protein_features":false,"name":"MCA1","ortholog_annotations":[{"gene_uniquename":"YOR197W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00135","reference_uniquename":"PMID:29761456"}],"product":"Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics and lifespan extension; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that block potential dimerization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005723","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR197W"}


id: YOR198C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00324":null,"YOR198C":null},"has_protein_features":false,"name":"BFR1","ortholog_annotations":[{"gene_uniquename":"YOR198C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00324","reference_uniquename":"PMID:29761456"}],"product":"Component of mRNP complexes associated with polyribosomes; involved in localization of mRNAs to P bodies; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR198C"}


id: YOR199W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005725","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR199W"}


id: YOR200W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c","secondary_identifier":"SGD:S000005726","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR200W"}


id: YOR201C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MRM1","product":"Ribose methyltransferase; modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA","secondary_identifier":"SGD:S000005727","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR201C"}


id: YOR202W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00592":null,"YOR202W":null},"has_protein_features":false,"name":"HIS3","ortholog_annotations":[{"gene_uniquename":"YOR202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00592","reference_uniquename":"PMID:29761456"}],"product":"Imidazoleglycerol-phosphate dehydratase; catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005728","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR202W"}


id: YOR203W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation","secondary_identifier":"SGD:S000005729","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR203W"}


id: YOR204W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00786":null,"YOR204W":null},"has_protein_features":false,"name":"DED1","ortholog_annotations":[{"gene_uniquename":"YOR204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00786","reference_uniquename":"PMID:29761456"}],"product":"ATP-dependent DEAD-box RNA helicase with strand-annealing activity; promotes eIF4F-dependent 48S translation preinitiation complex (PIC) assembly, stimulating recruitment of mRNAs with long, structured 5'-UTRs; cooperates with Dbp1p in PIC attachment and scanning; ATPase activity stimulated by mRNA cap-associated factor binding; directly binds eIF4G; role in spliceosomal complex disassembly; mutation in human homolog DBY associated with male infertility; human homolog DDX3X complements the null","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005730","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR204W"}


id: YOR205C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GEP3","product":"Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (Phb1p)","secondary_identifier":"SGD:S000005731","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR205C"}


id: YOR206W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01494":null,"SJAG_04346":null,"YOR206W":null},"has_protein_features":false,"name":"NOC2","ortholog_annotations":[{"gene_uniquename":"YOR206W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01494","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR206W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04346","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in ribosome biogenesis; forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes; forms a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005732","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR206W"}


id: YOR207C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00637":null,"YOR207C":null},"has_protein_features":false,"name":"RET1","ortholog_annotations":[{"gene_uniquename":"YOR207C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00637","reference_uniquename":"PMID:29761456"}],"product":"Second-largest subunit of RNA polymerase III; RNA polymerase III is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005733","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR207C"}


id: YOR208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02000":null,"SJAG_02013":null,"YOR208W":null},"has_protein_features":false,"name":"PTP2","ortholog_annotations":[{"gene_uniquename":"YOR208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02000","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02013","reference_uniquename":"PMID:29761456"}],"product":"Phosphotyrosine-specific phosphatase; major role in osmolarity sensing through dephosphorylation of the Hog1p MAPK with a minor role by Ptp3p; inactivates and regulates Hog1p localization; major role in the cell wall integrity pathway through dephosphorylation of MAPK Slt2p with a minor role by Ptp3p; minor role with Msg5p in the pheromone adaptive response through dephosphorylation of MAPK Fus3p with major role by Ptp3p; co-regulates the calcium signaling pathway with Msg5p; nuclear localized","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005734","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR208W"}


id: YOR209C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03298":null,"YOR209C":null},"has_protein_features":false,"name":"NPT1","ortholog_annotations":[{"gene_uniquename":"YOR209C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03298","reference_uniquename":"PMID:29761456"}],"product":"Nicotinate phosphoribosyltransferase; acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005735","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR209C"}


id: YOR210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01765":null,"YOR210W":null},"has_protein_features":false,"name":"RPB10","ortholog_annotations":[{"gene_uniquename":"YOR210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01765","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase subunit ABC10-beta; common to RNA polymerases I, II, and III","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005736","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR210W"}


id: YOR211C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02656":null,"YOR211C":null},"has_protein_features":false,"name":"MGM1","ortholog_annotations":[{"gene_uniquename":"YOR211C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02656","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mitochondrial morphology, fusion, and genome maintenance; promotes membrane bending; plays a direct role in formation and maintenance of lamellar, but not of tubular, cristae; exists as long and short form with different distributions; ratio of long to short forms is regulated by Psd1p; homolog of human OPA1 involved in autosomal dominant optic atrophy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005737","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR211C"}


id: YOR212W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03081":null,"YOR212W":null},"has_protein_features":false,"name":"STE4","ortholog_annotations":[{"gene_uniquename":"YOR212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03081","reference_uniquename":"PMID:29761456"}],"product":"G protein beta subunit; forms a dimer with Ste18p to activate mating signaling pathway, forms heterotrimer with Gpa1p and Ste18p to dampen signaling; pheromone-induced phosphorylation plays critical role in chemotropism; may recruit Rho1p to polarized growth site during mating; contains WD40 repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005738","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR212W"}


id: YOR213C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00735":null,"YOR213C":null},"has_protein_features":false,"name":"SAS5","ortholog_annotations":[{"gene_uniquename":"YOR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00735","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the SAS complex (Sas2p, Sas4p, Sas5p); acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000005739","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR213C"}


id: YOR214C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPR2","product":"Putative spore wall protein; expression increases during sporulation; not an essential gene; YOR214C has a paralog, SPO19, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005740","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR214C"}


id: YOR215C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AIM41","product":"Protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss","secondary_identifier":"SGD:S000005741","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR215C"}


id: YOR216C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04528":null,"YOR216C":null},"has_protein_features":false,"name":"RUD3","ortholog_annotations":[{"gene_uniquename":"YOR216C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04528","reference_uniquename":"PMID:29761456"}],"product":"Golgi matrix protein; involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005742","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR216C"}


id: YOR217W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00863":null,"YOR217W":null},"has_protein_features":false,"name":"RFC1","ortholog_annotations":[{"gene_uniquename":"YOR217W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00863","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005743","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR217W"}


id: YOR218C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W","secondary_identifier":"SGD:S000005744","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR218C"}


id: YOR219C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02565":null,"YOR219C":null},"has_protein_features":false,"name":"STE13","ortholog_annotations":[{"gene_uniquename":"YOR219C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02565","reference_uniquename":"PMID:29761456"}],"product":"Dipeptidyl aminopeptidase; Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005745","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR219C"}


id: YOR220W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RCN2","product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000005746","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR220W"}


id: YOR221C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03972":null,"YOR221C":null},"has_protein_features":false,"name":"MCT1","ortholog_annotations":[{"gene_uniquename":"YOR221C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03972","reference_uniquename":"PMID:29761456"}],"product":"Predicted malonyl-CoA:ACP transferase; putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005747","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR221C"}


id: YOR222W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00522":null,"YOR222W":null},"has_protein_features":false,"name":"ODC2","ortholog_annotations":[{"gene_uniquename":"YOR222W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00522","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism; ODC2 has a paralog, ODC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005748","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR222W"}


id: YOR223W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02703":null,"YOR223W":null},"has_protein_features":false,"name":"DSC3","ortholog_annotations":[{"gene_uniquename":"YOR223W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02703","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005749","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR223W"}


id: YOR224C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02070":null,"YOR224C":null},"has_protein_features":false,"name":"RPB8","ortholog_annotations":[{"gene_uniquename":"YOR224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02070","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase subunit ABC14.5; common to RNA polymerases I, II, and III","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005750","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR224C"}


id: YOR225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005751","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR225W"}


id: YOR226C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00532":null,"YOR226C":null},"has_protein_features":false,"name":"ISU2","ortholog_annotations":[{"gene_uniquename":"YOR226C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00532","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for iron-sulfur protein synthesis; performs scaffolding function during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; protein abundance increases under DNA replication stress; ISU2 has a paralog, ISU1, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005752","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR226C"}


id: YOR227W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HER1","product":"Protein of unknown function; required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005753","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR227W"}


id: YOR228C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MCP1","product":"Mitochondrial protein of unknown function involved in lipid homeostasis; integral membrane protein that localizes to the mitochondrial outer membrane; involved in mitochondrial morphology; interacts genetically with MDM10, and other members of the ERMES complex; contains five predicted transmembrane domains","secondary_identifier":"SGD:S000005754","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR228C"}


id: YOR229W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04758":null,"YOR229W":null},"has_protein_features":false,"name":"WTM2","ortholog_annotations":[{"gene_uniquename":"YOR229W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04758","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats; relocalizes to the cytosol in response to hypoxia; WTM2 has a paralog, UME1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005755","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR229W"}


id: YOR230W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04758":null,"YOR230W":null},"has_protein_features":false,"name":"WTM1","ortholog_annotations":[{"gene_uniquename":"YOR230W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04758","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; acts as a nuclear anchor to retain the ribonucleotide reductase small subunit heterodimer, Rnr2p-Rnr4p, in the nucleus when cells are not in S phase; contains WD repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005756","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR230W"}


id: YOR231C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028716","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR231C-A"}


id: YOR231W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01181":null,"YOR231W":null},"has_protein_features":false,"name":"MKK1","ortholog_annotations":[{"gene_uniquename":"YOR231W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01181","reference_uniquename":"PMID:29761456"}],"product":"MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005757","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR231W"}


id: YOR232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04014":null,"YOR232W":null},"has_protein_features":false,"name":"MGE1","ortholog_annotations":[{"gene_uniquename":"YOR232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04014","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial matrix cochaperone; nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; acts as oxidative sensor to regulate mitochondrial Ssc1p; in presence of oxidative stress, dimeric Mge1p becomes a monomer and unable to regulate Ssc1p function; homolog of E. coli GrpE and human Mge1 (GRPEL1), which also responds to oxidative stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005758","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR232W"}


id: YOR233W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04507":null,"YOR233W":null},"has_protein_features":false,"name":"KIN4","ortholog_annotations":[{"gene_uniquename":"YOR233W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04507","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005759","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR233W"}


id: YOR234C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00166":null,"SJAG_04414":null,"YOR234C":null},"has_protein_features":false,"name":"RPL33B","ortholog_annotations":[{"gene_uniquename":"YOR234C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00166","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR234C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04414","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005760","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR234C"}


id: YOR235W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IRC13","product":"Putative protein of unknown function; conserved across S. cerevisiae strains; null mutant displays increased levels of spontaneous Rad52 foci","secondary_identifier":"SGD:S000005761","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR235W"}


id: YOR236W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01198":null,"YOR236W":null},"has_protein_features":false,"name":"DFR1","ortholog_annotations":[{"gene_uniquename":"YOR236W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01198","reference_uniquename":"PMID:29761456"}],"product":"Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism; mutation is functionally complemented by human DHFR","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005762","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR236W"}


id: YOR237W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01590":null,"SJAG_02323":null,"SJAG_02375":null,"SJAG_03718":null,"YOR237W":null},"has_protein_features":false,"name":"HES1","ortholog_annotations":[{"gene_uniquename":"YOR237W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01590","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR237W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02323","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR237W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02375","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR237W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03718","reference_uniquename":"PMID:29761456"}],"product":"Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); SWAT-GFP and mCherry fusion proteins localize to the bud neck and vacuolar membrane; HES1 has a paralog, KES1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005763","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR237W"}


id: YOR238W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00190":null,"YOR238W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR238W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00190","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005764","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR238W"}


id: YOR239W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00499":null,"SJAG_04453":null,"YOR239W":null},"has_protein_features":false,"name":"ABP140","ortholog_annotations":[{"gene_uniquename":"YOR239W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00499","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR239W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04453","reference_uniquename":"PMID:29761456"}],"product":"AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005765","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR239W"}


id: YOR240W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YOR240W was originally annotated as an independent ORF, but was later demonstrated to be part of an adjacent ORF, YOR239W, via a +1 translational frameshift","secondary_identifier":"SGD:S000005766","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR240W"}


id: YOR241W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03224":null,"YOR241W":null},"has_protein_features":false,"name":"MET7","ortholog_annotations":[{"gene_uniquename":"YOR241W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03224","reference_uniquename":"PMID:29761456"}],"product":"Folylpolyglutamate synthetase; catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005767","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR241W"}


id: YOR242C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SSP2","product":"Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; expression controlled by a tightly regulated middle-meiotic promoter that is activated by Ndt80p; translation of SSP2 mRNA is delayed, such that the mRNA is present as nuclear divisions are taking place but is not engaged by ribosomes until relatively late in meiotic development","secondary_identifier":"SGD:S000005768","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR242C"}


id: YOR243C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03572":null,"YOR243C":null},"has_protein_features":false,"name":"PUS7","ortholog_annotations":[{"gene_uniquename":"YOR243C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03572","reference_uniquename":"PMID:29761456"}],"product":"Pseudouridine synthase; catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); also pseudouridylates some mRNAs; relocates from nucleus to cytoplasm during heat shock and differentially modifies some mRNAs during heat shock; conserved in archaea, vertebrates, and some bacteria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005769","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR243C"}


id: YOR244W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02990":null,"YOR244W":null},"has_protein_features":false,"name":"ESA1","ortholog_annotations":[{"gene_uniquename":"YOR244W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02990","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; master regulator of cellular acetylation balance; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; human ortholog TIP60/KAT5 is implicated in cancer and other diseases, functionally complements lethality of the esa1 null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005770","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR244W"}


id: YOR245C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03609":null,"YOR245C":null},"has_protein_features":false,"name":"DGA1","ortholog_annotations":[{"gene_uniquename":"YOR245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03609","reference_uniquename":"PMID:29761456"}],"product":"Diacylglycerol acyltransferase; catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor; Lro1p and Dga1p can O-acylate ceramides; localized to lipid particles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005771","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR245C"}


id: YOR246C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02623":null,"YOR246C":null},"has_protein_features":false,"name":"ENV9","ortholog_annotations":[{"gene_uniquename":"YOR246C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02623","reference_uniquename":"PMID:29761456"}],"product":"Conserved oxidoreductase involved in lipid droplet morphology; mutant shows defects in CPY processing and vacuolar morphology; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts; homologus to human RDH12 linked to Leber Congenital Amaurosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005772","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR246C"}


id: YOR247W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SRL1","product":"Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005773","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR247W"}


id: YOR248W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005774","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR248W"}


id: YOR249C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04661":null,"YOR249C":null},"has_protein_features":false,"name":"APC5","ortholog_annotations":[{"gene_uniquename":"YOR249C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04661","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005775","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR249C"}


id: YOR250C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01791":null,"YOR250C":null},"has_protein_features":false,"name":"CLP1","ortholog_annotations":[{"gene_uniquename":"YOR250C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01791","reference_uniquename":"PMID:29761456"}],"product":"Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation and in gene looping which affects reinitiation of transcription; mutations in human ortholog cause cerebellar neurodegeneration","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005776","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR250C"}


id: YOR251C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04113":null,"YOR251C":null},"has_protein_features":false,"name":"TUM1","ortholog_annotations":[{"gene_uniquename":"YOR251C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04113","reference_uniquename":"PMID:29761456"}],"product":"Rhodanese domain sulfur transferase; accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; involved in metabolism of sterol esters; may be mitochondrially localized","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005777","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR251C"}


id: YOR252W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TMA16","product":"Protein of unknown function that associates with ribosomes","secondary_identifier":"SGD:S000005778","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR252W"}


id: YOR253W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02726":null,"YOR253W":null},"has_protein_features":false,"name":"NAT5","ortholog_annotations":[{"gene_uniquename":"YOR253W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02726","reference_uniquename":"PMID:29761456"}],"product":"Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005779","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR253W"}


id: YOR254C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00175":null,"YOR254C":null},"has_protein_features":false,"name":"SEC63","ortholog_annotations":[{"gene_uniquename":"YOR254C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00175","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; other members are Sec62p, Sec66p, and Sec72p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005780","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR254C"}


id: YOR255W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OSW1","product":"Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p","secondary_identifier":"SGD:S000005781","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR255W"}


id: YOR256C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02117":null,"YOR256C":null},"has_protein_features":false,"name":"TRE2","ortholog_annotations":[{"gene_uniquename":"YOR256C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02117","reference_uniquename":"PMID:29761456"}],"product":"Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitination and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005782","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR256C"}


id: YOR257W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01760":null,"YOR257W":null},"has_protein_features":false,"name":"CDC31","ortholog_annotations":[{"gene_uniquename":"YOR257W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01760","reference_uniquename":"PMID:29761456"}],"product":"Calcium-binding component of the spindle pole body (SPB) half-bridge; required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005783","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR257W"}


id: YOR258W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04410":null,"YOR258W":null},"has_protein_features":false,"name":"HNT3","ortholog_annotations":[{"gene_uniquename":"YOR258W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04410","reference_uniquename":"PMID:29761456"}],"product":"DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR258W"}


id: YOR259C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00766":null,"YOR259C":null},"has_protein_features":false,"name":"RPT4","ortholog_annotations":[{"gene_uniquename":"YOR259C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00766","reference_uniquename":"PMID:29761456"}],"product":"ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005785","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR259C"}


id: YOR260W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01659":null,"YOR260W":null},"has_protein_features":false,"name":"GCD1","ortholog_annotations":[{"gene_uniquename":"YOR260W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01659","reference_uniquename":"PMID:29761456"}],"product":"Gamma subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005786","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR260W"}


id: YOR261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00762":null,"YOR261C":null},"has_protein_features":false,"name":"RPN8","ortholog_annotations":[{"gene_uniquename":"YOR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00762","reference_uniquename":"PMID:29761456"}],"product":"Essential non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005787","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR261C"}


id: YOR262W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00065":null,"YOR262W":null},"has_protein_features":false,"name":"GPN2","ortholog_annotations":[{"gene_uniquename":"YOR262W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00065","reference_uniquename":"PMID:29761456"}],"product":"Putative GTPase with a specific role in RNA pol II and polIII biogenesis; involved in the assembly and subsequent nuclear import of RNA polymerases II and III; required for establishment of sister chromatid cohesion; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005788","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR262W"}


id: YOR263C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W","secondary_identifier":"SGD:S000005789","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR263C"}


id: YOR264W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DSE3","product":"Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress; interacts with Csm1p","secondary_identifier":"SGD:S000005790","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR264W"}


id: YOR265W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02270":null,"YOR265W":null},"has_protein_features":false,"name":"RBL2","ortholog_annotations":[{"gene_uniquename":"YOR265W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02270","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005791","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR265W"}


id: YOR266W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PNT1","product":"Mitochondrial integral inner membrane protein; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine","secondary_identifier":"SGD:S000005792","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR266W"}


id: YOR267C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00963":null,"SJAG_04268":null,"YOR267C":null},"has_protein_features":false,"name":"HRK1","ortholog_annotations":[{"gene_uniquename":"YOR267C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00963","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR267C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04268","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005793","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR267C"}


id: YOR268C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; sporulation is abnormal in homozygous diploid; SWAT-GFP fusion protein localizes to the nucleus; YOR268C is not an essential gene","secondary_identifier":"SGD:S000005794","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR268C"}


id: YOR269W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00511":null,"YOR269W":null},"has_protein_features":false,"name":"PAC1","ortholog_annotations":[{"gene_uniquename":"YOR269W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00511","reference_uniquename":"PMID:26896847"}],"product":"Regulator of dynein, involved in intracellular transport; part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000005795","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR269W"}


id: YOR270C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00516":null,"YOR270C":null},"has_protein_features":false,"name":"VPH1","ortholog_annotations":[{"gene_uniquename":"YOR270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00516","reference_uniquename":"PMID:29761456"}],"product":"Subunit a of the vacuolar-ATPase V0 domain; encodes one of two isoforms, located in vacuolar V-ATPase complexes while STV1 encodes the second isoform and is located in Golgi and endosomal V-ATPase complexes; interaction with PI(3,5)P2 increases V-ATPase activity and contributes to hyperosmotic stress tolerance; relative distribution to the vacuolar membrane decreases upon DNA replication stress; human homolog ATP6V0A4 implicated in renal tubular acidosis, can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005796","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR270C"}


id: YOR271C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04588":null,"YOR271C":null},"has_protein_features":false,"name":"FSF1","ortholog_annotations":[{"gene_uniquename":"YOR271C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04588","reference_uniquename":"PMID:29761456"}],"product":"Putative protein; predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005797","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR271C"}


id: YOR272W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02759":null,"YOR272W":null},"has_protein_features":false,"name":"YTM1","ortholog_annotations":[{"gene_uniquename":"YOR272W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02759","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal assembly factor and 66S pre-ribosomal particle constituent; subunit of the Nop7-subcomplex (PeBoW complex), required for an early nucleolar step in pre-60S ribosomal particle maturation; interaction of its ubiquitin-like (UBL) domain with the MIDAS domain in the Rea1p tail triggers release of the subcomplex and possibly other biogenesis factors via cycles of ATP hydrolysis; involved in the processing of 27S pre-rRNA; contains an N-terminal UBL domain and seven C-terminal WD repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005798","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR272W"}


id: YOR273C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TPO4","product":"Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane","secondary_identifier":"SGD:S000005799","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR273C"}


id: YOR274W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01575":null,"YOR274W":null},"has_protein_features":false,"name":"MOD5","ortholog_annotations":[{"gene_uniquename":"YOR274W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01575","reference_uniquename":"PMID:29761456"}],"product":"Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; also has a role in tRNA gene-mediated silencing; gene encodes two isozymic forms; converts to a prion form, prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis; homolog of human TRIT1, a mutation in which is associated with severe combined respiratory chain defects","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005800","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR274W"}


id: YOR275C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02584":null,"SJAG_03891":null,"YOR275C":null},"has_protein_features":false,"name":"RIM20","ortholog_annotations":[{"gene_uniquename":"YOR275C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02584","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOR275C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03891","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005801","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR275C"}


id: YOR276W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CAF20","product":"Phosphoprotein of the mRNA cap-binding complex; involved in translational control; repressor of cap-dependent translational initiation; translational activator of select mRNAs during filamentous growth; competes with eIF4G for binding to eIF4E","secondary_identifier":"SGD:S000005802","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR276W"}


id: YOR277C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20","secondary_identifier":"SGD:S000005803","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR277C"}


id: YOR278W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05283":null,"YOR278W":null},"has_protein_features":false,"name":"HEM4","ortholog_annotations":[{"gene_uniquename":"YOR278W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05283","reference_uniquename":"PMID:29761456"}],"product":"Uroporphyrinogen III synthase; catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005804","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR278W"}


id: YOR279C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RFM1","product":"Component of the Sum1p-Rfm1p-Hst1p complex; Rfm1p tethers the Hst1p histone deacetylase to the DNA-binding protein Sum1p; complex is involved in transcriptional repression of middle sporulation genes and in initiation of DNA replication","secondary_identifier":"SGD:S000005805","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR279C"}


id: YOR280C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01198":null,"SJAG_03760":null,"YOR280C":null},"has_protein_features":false,"name":"FSH3","ortholog_annotations":[{"gene_uniquename":"YOR280C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01198","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR280C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03760","reference_uniquename":"PMID:26896847"}],"product":"Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR280C"}


id: YOR281C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00558":null,"YOR281C":null},"has_protein_features":false,"name":"PLP2","ortholog_annotations":[{"gene_uniquename":"YOR281C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00558","reference_uniquename":"PMID:29761456"}],"product":"Protein that interacts with the CCT complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP; CCT is short for chaperonin containing TCP-1; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR281C"}


id: YOR282W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C","secondary_identifier":"SGD:S000005808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR282W"}


id: YOR283W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00685":null,"YOR283W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR283W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00685","reference_uniquename":"PMID:29761456"}],"product":"Phosphatase with a broad substrate specificity; has some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005809","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR283W"}


id: YOR284W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HUA2","product":"Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly","secondary_identifier":"SGD:S000005810","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR284W"}


id: YOR285W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01239":null,"YOR285W":null},"has_protein_features":false,"name":"RDL1","ortholog_annotations":[{"gene_uniquename":"YOR285W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01239","reference_uniquename":"PMID:29761456"}],"product":"Thiosulfate sulfurtransferase; contains a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress; similar to the human TSTD gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR285W"}


id: YOR286W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01239":null,"YOR286W":null},"has_protein_features":false,"name":"RDL2","ortholog_annotations":[{"gene_uniquename":"YOR286W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01239","reference_uniquename":"PMID:29761456"}],"product":"Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR286W"}


id: YOR287C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04979":null,"YOR287C":null},"has_protein_features":false,"name":"RRP36","ortholog_annotations":[{"gene_uniquename":"YOR287C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04979","reference_uniquename":"PMID:29761456"}],"product":"Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005813","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR287C"}


id: YOR288C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04046":null,"YOR288C":null},"has_protein_features":false,"name":"MPD1","ortholog_annotations":[{"gene_uniquename":"YOR288C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04046","reference_uniquename":"PMID:29761456"}],"product":"Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005814","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR288C"}


id: YOR289W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05222":null,"YOR289W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR289W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05222","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005815","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR289W"}


id: YOR290C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04755":null,"SJAG_05313":null,"YOR290C":null},"has_protein_features":false,"name":"SNF2","ortholog_annotations":[{"gene_uniquename":"YOR290C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04755","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR290C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05313","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005816","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR290C"}


id: YOR291W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03866":null,"SJAG_04757":null,"YOR291W":null},"has_protein_features":false,"name":"YPK9","ortholog_annotations":[{"gene_uniquename":"YOR291W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03866","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR291W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04757","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar protein with a possible role in sequestering heavy metals; involved in the oxidative stress response and modulation of replicative lifespan; undergoes autophosphorylation, which is abolished by mutation of Asp781 in the catalytic motif (D781N); P5 ATPase subfamily member with similarity to yeast Spf1p and homology of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005817","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR291W"}


id: YOR292C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00631":null,"SJAG_01649":null,"YOR292C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR292C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00631","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOR292C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01649","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005818","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR292C"}


id: YOR293C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028858","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR293C-A"}


id: YOR293W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02904":null,"SJAG_04695":null,"YOR293W":null},"has_protein_features":false,"name":"RPS10A","ortholog_annotations":[{"gene_uniquename":"YOR293W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02904","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR293W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04695","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication; mutations in the human homolog associated with Diamond-Blackfan anemia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005819","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR293W"}


id: YOR294W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02644":null,"YOR294W":null},"has_protein_features":false,"name":"RRS1","ortholog_annotations":[{"gene_uniquename":"YOR294W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02644","reference_uniquename":"PMID:29761456"}],"product":"Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005820","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR294W"}


id: YOR295W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02747":null,"YOR295W":null},"has_protein_features":false,"name":"UAF30","ortholog_annotations":[{"gene_uniquename":"YOR295W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02747","reference_uniquename":"PMID:29761456"}],"product":"Subunit of UAF (upstream activation factor) complex; UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; targeting factor for the UAF that facilitates activation of many rDNA genes; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005821","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR295W"}


id: YOR296W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00472":null,"SJAG_02572":null,"YOR296W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR296W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00472","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOR296W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02572","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005822","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR296W"}


id: YOR297C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02398":null,"YOR297C":null},"has_protein_features":false,"name":"TIM18","ortholog_annotations":[{"gene_uniquename":"YOR297C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02398","reference_uniquename":"PMID:29761456"}],"product":"Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005823","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR297C"}


id: YOR298C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00269":null,"YOR298C-A":null},"has_protein_features":false,"name":"MBF1","ortholog_annotations":[{"gene_uniquename":"YOR298C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00269","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR298C-A"}


id: YOR298W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MUM3","product":"Protein of unknown function involved in outer spore wall organization; has similarity to the tafazzins superfamily of acyltransferases","secondary_identifier":"SGD:S000005824","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR298W"}


id: YOR299W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00916":null,"YOR299W":null},"has_protein_features":false,"name":"BUD7","ortholog_annotations":[{"gene_uniquename":"YOR299W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00916","reference_uniquename":"PMID:29761456"}],"product":"Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005825","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR299W"}


id: YOR300W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7","secondary_identifier":"SGD:S000005826","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR300W"}


id: YOR301W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00745":null,"YOR301W":null},"has_protein_features":false,"name":"RAX1","ortholog_annotations":[{"gene_uniquename":"YOR301W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00745","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in establishing bud site selection; localizes to the bud neck and previous sites of cell division (bud scars or cytokinesis remnants (CRMs); localization to both sites is interdependent with Rax2p; required with Rax2p to anchor Nba1p and Nis1p to CRMs where a Cdc42p inhibitory zone is established, preventing repolarization of cells at previous division sites; predicted type IIIa transmembrane protein with similarity to members of the insulin-related peptide superfamily","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005827","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR301W"}


id: YOR302W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"CPA1 uORF; Arginine attenuator peptide, regulates translation of the CPA1 mRNA","secondary_identifier":"SGD:S000005828","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR302W"}


id: YOR303W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00392":null,"YOR303W":null},"has_protein_features":false,"name":"CPA1","ortholog_annotations":[{"gene_uniquename":"YOR303W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00392","reference_uniquename":"PMID:29761456"}],"product":"Small subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005829","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR303W"}


id: YOR304C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BIL1","product":"Protein that binds Bud6p and has a role in actin cable assembly; involved in the Bnr1p-dependent pathway of cable assembly; localizes to bud tip and bud neck","secondary_identifier":"SGD:S000005830","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR304C-A"}


id: YOR304W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ISW2","product":"ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth; exhibits basal levels of chromatin binding throughout the genome as well as interacts with sequence-specific factors to accurately position nucleosomes in chromatin; targeted by Ume6p- and Sua7p-dependent DNA looping to many loci genome-wide","secondary_identifier":"SGD:S000005831","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR304W"}


id: YOR305W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01569":null,"YOR305W":null},"has_protein_features":false,"name":"RRG7","ortholog_annotations":[{"gene_uniquename":"YOR305W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01569","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005832","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR305W"}


id: YOR306C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MCH5","product":"Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport","secondary_identifier":"SGD:S000005833","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR306C"}


id: YOR307C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00276":null,"YOR307C":null},"has_protein_features":false,"name":"SLY41","ortholog_annotations":[{"gene_uniquename":"YOR307C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00276","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in ER-to-Golgi transport; packaged into COPII vesicles for trafficking between ER and Golgi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005834","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR307C"}


id: YOR308C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04433":null,"YOR308C":null},"has_protein_features":false,"name":"SNU66","ortholog_annotations":[{"gene_uniquename":"YOR308C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04433","reference_uniquename":"PMID:29761456"}],"product":"Component of the U4/U6.U5 snRNP complex; involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005835","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR308C"}


id: YOR309C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58","secondary_identifier":"SGD:S000005836","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR309C"}


id: YOR310C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00744":null,"YOR310C":null},"has_protein_features":false,"name":"NOP58","ortholog_annotations":[{"gene_uniquename":"YOR310C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00744","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in producing mature rRNAs and snoRNAs; involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005837","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR310C"}


id: YOR311C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04883":null,"YOR311C":null},"has_protein_features":false,"name":"DGK1","ortholog_annotations":[{"gene_uniquename":"YOR311C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04883","reference_uniquename":"PMID:29761456"}],"product":"Diacylglycerol kinase; localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005838","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR311C"}


id: YOR312C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02283":null,"SJAG_04897":null,"YOR312C":null},"has_protein_features":false,"name":"RPL20B","ortholog_annotations":[{"gene_uniquename":"YOR312C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02283","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR312C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04897","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005839","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR312C"}


id: YOR313C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPS4","product":"Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage","secondary_identifier":"SGD:S000005840","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR313C"}


id: YOR314W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000005841","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR314W"}


id: YOR314W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR314W-A"}


id: YOR315W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SFG1","product":"Nuclear protein putative transcription factor; required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate","secondary_identifier":"SGD:S000005842","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR315W"}


id: YOR316C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01078":null,"SJAG_01803":null,"YOR316C":null},"has_protein_features":false,"name":"COT1","ortholog_annotations":[{"gene_uniquename":"YOR316C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01078","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR316C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01803","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005843","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR316C"}


id: YOR316C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028584","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR316C-A"}


id: YOR317W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03471":null,"SJAG_03909":null,"YOR317W":null},"has_protein_features":false,"name":"FAA1","ortholog_annotations":[{"gene_uniquename":"YOR317W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03471","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR317W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03909","reference_uniquename":"PMID:29761456"}],"product":"Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatty acids and sphingoid long-chain bases; accounts for most acyl-CoA synthetase activity; localizes to lipid particles and the plasma membrane; role in sphingolipid-to-glycerolipid metabolism; forms ER foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6, SLC27A2, or 4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005844","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR317W"}


id: YOR318C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo","secondary_identifier":"SGD:S000005845","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR318C"}


id: YOR319W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00504":null,"YOR319W":null},"has_protein_features":false,"name":"HSH49","ortholog_annotations":[{"gene_uniquename":"YOR319W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00504","reference_uniquename":"PMID:29761456"}],"product":"U2-snRNP associated splicing factor; similar to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005846","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR319W"}


id: YOR320C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03149":null,"SJAG_03150":null,"YOR320C":null},"has_protein_features":false,"name":"GNT1","ortholog_annotations":[{"gene_uniquename":"YOR320C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR320C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03150","reference_uniquename":"PMID:29761456"}],"product":"N-acetylglucosaminyltransferase; capable of modification of N-linked glycans in the Golgi apparatus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005847","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR320C"}


id: YOR321W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04053":null,"YOR321W":null},"has_protein_features":false,"name":"PMT3","ortholog_annotations":[{"gene_uniquename":"YOR321W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04053","reference_uniquename":"PMID:29761456"}],"product":"Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005848","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR321W"}


id: YOR322C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02789":null,"SJAG_03404":null,"YOR322C":null},"has_protein_features":false,"name":"LDB19","ortholog_annotations":[{"gene_uniquename":"YOR322C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02789","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR322C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03404","reference_uniquename":"PMID:29761456"}],"product":"Alpha-arrestin, Ub-ligase adaptor for Rsp5p; regulates starvation- and substrate-induced Ub-dependent endocytosis of select plasma membrane localized amino acid transporters, recruiting Rsp5p to its targets; role in basal internalization and turnover of Ste2p, mating and zygote formation; recruits Rsp5p to Ste2p via its 2 PPXY motifs; inhibited by Npr1p-mediated phosphorylation, affecting cytosol and plasma membrane translocation; localization regulated by Rsp5p-dependent ubiquitination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005849","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR322C"}


id: YOR323C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00660":null,"YOR323C":null},"has_protein_features":false,"name":"PRO2","ortholog_annotations":[{"gene_uniquename":"YOR323C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00660","reference_uniquename":"PMID:29761456"}],"product":"Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005850","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR323C"}


id: YOR324C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FRT1","product":"Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005851","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR324C"}


id: YOR325W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1","secondary_identifier":"SGD:S000005852","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR325W"}


id: YOR326W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00938":null,"SJAG_03011":null,"YOR326W":null},"has_protein_features":false,"name":"MYO2","ortholog_annotations":[{"gene_uniquename":"YOR326W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00938","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR326W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03011","reference_uniquename":"PMID:29761456"}],"product":"Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, lipid droplets, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005853","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR326W"}


id: YOR327C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02241":null,"YOR327C":null},"has_protein_features":false,"name":"SNC2","ortholog_annotations":[{"gene_uniquename":"YOR327C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02241","reference_uniquename":"PMID:29761456"}],"product":"Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; Snc2p levels regulated by Vps45p; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005854","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR327C"}


id: YOR328W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04277":null,"YOR328W":null},"has_protein_features":false,"name":"PDR10","ortholog_annotations":[{"gene_uniquename":"YOR328W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"ATP-binding cassette (ABC) transporter; multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005855","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR328W"}


id: YOR329C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SCD5","product":"Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency","secondary_identifier":"SGD:S000005856","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR329C"}


id: YOR329W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028585","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR329W-A"}


id: YOR330C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02658":null,"YOR330C":null},"has_protein_features":false,"name":"MIP1","ortholog_annotations":[{"gene_uniquename":"YOR330C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02658","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial DNA polymerase gamma; single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoan complex of catalytic and accessory subunits; polymorphic in yeast, petites occur more frequently in some lab strains; human ortholog POLG complements yeast mip1 mutant; mutations in human POLG associated with Alpers-Huttenlocher syndrome (AHS), progressive external ophthalmoplegia (PEO), parkinsonism, other mitochondrial diseases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005857","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR330C"}


id: YOR331C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W","secondary_identifier":"SGD:S000005858","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR331C"}


id: YOR332W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00212":null,"YOR332W":null},"has_protein_features":false,"name":"VMA4","ortholog_annotations":[{"gene_uniquename":"YOR332W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00212","reference_uniquename":"PMID:29761456"}],"product":"Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005859","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR332W"}


id: YOR333C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of MRS2 gene required for respiratory growth","secondary_identifier":"SGD:S000005860","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR333C"}


id: YOR334W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01639":null,"YOR334W":null},"has_protein_features":false,"name":"MRS2","ortholog_annotations":[{"gene_uniquename":"YOR334W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01639","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; similar to bacterial CorA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005861","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR334W"}


id: YOR335C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01797":null,"YOR335C":null},"has_protein_features":false,"name":"ALA1","ortholog_annotations":[{"gene_uniquename":"YOR335C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01797","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic and mitochondrial alanyl-tRNA synthetase; required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog AARS; mutations in human homolog AARS are associated with autoimmune disease polymyositis/dermatomyositis and with hereditary peripheral neuropathy, Charcot-Marie-Tooth (CMT) disease","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005862","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR335C"}


id: YOR335W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ALA1/YOR335C","secondary_identifier":"SGD:S000028717","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR335W-A"}


id: YOR336W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04571":null,"YOR336W":null},"has_protein_features":false,"name":"KRE5","ortholog_annotations":[{"gene_uniquename":"YOR336W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04571","reference_uniquename":"PMID:29761456"}],"product":"Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005863","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR336W"}


id: YOR337W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05337":null,"YOR337W":null},"has_protein_features":false,"name":"TEA1","ortholog_annotations":[{"gene_uniquename":"YOR337W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05337","reference_uniquename":"PMID:29761456"}],"product":"Ty1 enhancer activator involved in Ty enhancer-mediated transcription; required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005864","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR337W"}


id: YOR338W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03441":null,"YOR338W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR338W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03441","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005865","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR338W"}


id: YOR339C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01679":null,"YOR339C":null},"has_protein_features":false,"name":"UBC11","ortholog_annotations":[{"gene_uniquename":"YOR339C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01679","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-conjugating enzyme; most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005866","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR339C"}


id: YOR340C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01562":null,"YOR340C":null},"has_protein_features":false,"name":"RPA43","ortholog_annotations":[{"gene_uniquename":"YOR340C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01562","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase I subunit A43","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005867","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR340C"}


id: YOR341W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03144":null,"YOR341W":null},"has_protein_features":false,"name":"RPA190","ortholog_annotations":[{"gene_uniquename":"YOR341W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03144","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase I largest subunit A190","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005868","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR341W"}


id: YOR342C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005869","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR342C"}


id: YOR343C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000005870","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR343C"}


id: YOR344C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TYE7","product":"Serine-rich protein that contains a bHLH DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression; bHLH stands for basic-helix-loop-helix","secondary_identifier":"SGD:S000005871","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR344C"}


id: YOR345C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2","secondary_identifier":"SGD:S000005872","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR345C"}


id: YOR346W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03906":null,"YOR346W":null},"has_protein_features":false,"name":"REV1","ortholog_annotations":[{"gene_uniquename":"YOR346W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03906","reference_uniquename":"PMID:29761456"}],"product":"Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress; may be involved in meiosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005873","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR346W"}


id: YOR347C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02796":null,"YOR347C":null},"has_protein_features":false,"name":"PYK2","ortholog_annotations":[{"gene_uniquename":"YOR347C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02796","reference_uniquename":"PMID:29761456"}],"product":"Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005874","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR347C"}


id: YOR348C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04718":null,"YOR348C":null},"has_protein_features":false,"name":"PUT4","ortholog_annotations":[{"gene_uniquename":"YOR348C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04718","reference_uniquename":"PMID:29761456"}],"product":"Proline permease; required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005875","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR348C"}


id: YOR349W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04074":null,"YOR349W":null},"has_protein_features":false,"name":"CIN1","ortholog_annotations":[{"gene_uniquename":"YOR349W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04074","reference_uniquename":"PMID:29761456"}],"product":"Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005876","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR349W"}


id: YOR350C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MNE1","product":"Protein involved in splicing Group I aI5-beta intron from COX1 mRNA; mitochondrial matrix protein","secondary_identifier":"SGD:S000005877","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR350C"}


id: YOR351C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03438":null,"YOR351C":null},"has_protein_features":false,"name":"MEK1","ortholog_annotations":[{"gene_uniquename":"YOR351C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03438","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific serine/threonine protein kinase; functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids; stabilizes Hop1-Thr318 phosphorylation to promote interhomolog recombination and checkpoint responses during meiosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005878","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR351C"}


id: YOR352W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04420":null,"YOR352W":null},"has_protein_features":false,"name":"TFB6","ortholog_annotations":[{"gene_uniquename":"YOR352W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04420","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005879","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR352W"}


id: YOR353C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00317":null,"YOR353C":null},"has_protein_features":false,"name":"SOG2","ortholog_annotations":[{"gene_uniquename":"YOR353C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00317","reference_uniquename":"PMID:29761456"}],"product":"Key component of the RAM signaling network; required for proper cell morphogenesis and cell separation after mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005880","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR353C"}


id: YOR354C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MSC6","product":"Multicopy suppressor of HER2 involved in mitochondrial translation; mutant is defective in directing meiotic recombination events to homologous chromatids","secondary_identifier":"SGD:S000005881","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR354C"}


id: YOR355W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GDS1","product":"Protein involved in histone H4 acetylation at ribosomal protein genes; interacts with and modulates NuA4 histone acetyltransferase complex; required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a segment predicted to resemble the winged-helix/forkhead domain located in DNA-binding proteins","secondary_identifier":"SGD:S000005882","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR355W"}


id: YOR356W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CIR2","product":"Putative ortholog of human ETF-dH; found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response; ETF-dH is also known as electron transfer flavoprotein dehydrogenase","secondary_identifier":"SGD:S000005883","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR356W"}


id: YOR357C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00314":null,"YOR357C":null},"has_protein_features":false,"name":"SNX3","ortholog_annotations":[{"gene_uniquename":"YOR357C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00314","reference_uniquename":"PMID:29761456"}],"product":"Sorting nexin for late-Golgi enzymes; required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005884","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR357C"}


id: YOR358W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01062":null,"YOR358W":null},"has_protein_features":false,"name":"HAP5","ortholog_annotations":[{"gene_uniquename":"YOR358W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01062","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005885","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR358W"}


id: YOR359W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03113":null,"YOR359W":null},"has_protein_features":false,"name":"VTS1","ortholog_annotations":[{"gene_uniquename":"YOR359W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03113","reference_uniquename":"PMID:29761456"}],"product":"Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif (SAM) domain that interacts with Smg recognition element (SREs) containing transcripts; stimulates Dna2p endonuclease activity; forms [SMAUG+] prion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005886","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR359W"}


id: YOR360C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PDE2","product":"High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon","secondary_identifier":"SGD:S000005887","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR360C"}


id: YOR361C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04744":null,"YOR361C":null},"has_protein_features":false,"name":"PRT1","ortholog_annotations":[{"gene_uniquename":"YOR361C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04744","reference_uniquename":"PMID:29761456"}],"product":"eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes; eIF3 is also involved in programmed stop codon readthrough","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005888","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR361C"}


id: YOR362C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00778":null,"YOR362C":null},"has_protein_features":false,"name":"PRE10","ortholog_annotations":[{"gene_uniquename":"YOR362C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00778","reference_uniquename":"PMID:29761456"}],"product":"Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005889","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR362C"}


id: YOR363C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PIP2","product":"Autoregulatory, oleate-activated transcription factor; subunit of a heterodimeric complex with Oaf1p, which binds to oleate-response elements (ORE) in the promoter of genes involved in beta-oxidation of fatty acids, peroxisome organization and biogenesis, activating transcription in the presence of oleate; PIP2 has a paralog, OAF1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005890","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR363C"}


id: YOR364W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C","secondary_identifier":"SGD:S000005891","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR364W"}


id: YOR365C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02727":null,"SJAG_04668":null,"YOR365C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR365C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02727","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR365C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04668","reference_uniquename":"PMID:29761456"}],"product":"Putative protein involved in sphingolipid biosynthesis; not an essential gene; YOR365C has a paralog, FLC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005892","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR365C"}


id: YOR366W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C","secondary_identifier":"SGD:S000005893","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR366W"}


id: YOR367W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SCP1","product":"Component of yeast cortical actin cytoskeleton; binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin","secondary_identifier":"SGD:S000005894","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR367W"}


id: YOR368W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02771":null,"YOR368W":null},"has_protein_features":false,"name":"RAD17","ortholog_annotations":[{"gene_uniquename":"YOR368W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02771","reference_uniquename":"PMID:29761456"}],"product":"Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005895","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR368W"}


id: YOR369C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03262":null,"YOR369C":null},"has_protein_features":false,"name":"RPS12","ortholog_annotations":[{"gene_uniquename":"YOR369C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03262","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005896","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR369C"}


id: YOR370C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02063":null,"YOR370C":null},"has_protein_features":false,"name":"MRS6","ortholog_annotations":[{"gene_uniquename":"YOR370C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02063","reference_uniquename":"PMID:29761456"}],"product":"Rab escort protein; type II geranylgeranyltransferase complex (Bet2p-Bet4p) chaperone that complexes with newly synthesized Rab GTPases, like Ypt1p and Sec4p, leading to their prenylation and membrane delivery; modulates the TOR pathway through interactions with Sfp1p; alters the kinetics of MAPK pathway activation and polarity reorganization during filamentous growth; sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005897","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR370C"}


id: YOR371C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GPB1","product":"Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005898","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR371C"}


id: YOR372C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NDD1","product":"Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes; turnover is tightly regulated during cell cycle and in response to DNA damage","secondary_identifier":"SGD:S000005899","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR372C"}


id: YOR373W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01188":null,"YOR373W":null},"has_protein_features":false,"name":"NUD1","ortholog_annotations":[{"gene_uniquename":"YOR373W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01188","reference_uniquename":"PMID:29761456"}],"product":"Mitotic exit network (MEN) scaffold protein; core component of the SPB outer plaque that functions in astral microtubule organization via Spc72p; scaffold for recruitment of MEN components, such as Cdc15p, Tem1p and the Bfa1p-Bub2p checkpoint complex; phosphorylation by Cdc15p creates a Dbf2p-Mob1p phospho-docking site enabling Cdc15p-dependent complex activation and mitotic exit; acts through the MEN to specify Kar9p-mediated asymmetric SPB inheritance; homologous to mammalian centriolin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005900","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR373W"}


id: YOR374W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03786":null,"YOR374W":null},"has_protein_features":false,"name":"ALD4","ortholog_annotations":[{"gene_uniquename":"YOR374W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03786","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial aldehyde dehydrogenase; required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed; can substitute for cytosolic NADP-dependent aldehyde dehydrogenase when directed to the cytosol; human homolog ALDH2 can complement yeast ald4 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005901","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR374W"}


id: YOR375C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03266":null,"YOR375C":null},"has_protein_features":false,"name":"GDH1","ortholog_annotations":[{"gene_uniquename":"YOR375C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03266","reference_uniquename":"PMID:29761456"}],"product":"NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005902","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR375C"}


id: YOR376W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YOR376W is not an essential gene","secondary_identifier":"SGD:S000005903","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR376W"}


id: YOR376W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028586","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR376W-A"}


id: YOR377W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATF1","product":"Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism","secondary_identifier":"SGD:S000005904","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR377W"}


id: YOR378W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AMF1","product":"Low affinity NH4+ transporter; member of the DHA2 family of drug:H+ anti porters; putative paralog of ATR1; but not required for boron tolerance; non-essential gene","secondary_identifier":"SGD:S000005905","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR378W"}


id: YOR379C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W","secondary_identifier":"SGD:S000005906","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR379C"}


id: YOR380W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RDR1","product":"Transcriptional repressor involved in regulating multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins","secondary_identifier":"SGD:S000005907","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR380W"}


id: YOR381W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04743":null,"YOR381W":null},"has_protein_features":false,"name":"FRE3","ortholog_annotations":[{"gene_uniquename":"YOR381W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Ferric reductase; reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005908","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR381W"}


id: YOR381W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR381W-A"}


id: YOR382W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FIT2","product":"Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall","secondary_identifier":"SGD:S000005909","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR382W"}


id: YOR383C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FIT3","product":"Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall","secondary_identifier":"SGD:S000005910","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR383C"}


id: YOR384W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04743":null,"YOR384W":null},"has_protein_features":false,"name":"FRE5","ortholog_annotations":[{"gene_uniquename":"YOR384W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005911","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR384W"}


id: YOR385W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene","secondary_identifier":"SGD:S000005912","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR385W"}


id: YOR386W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PHR1","product":"DNA photolyase involved in photoreactivation; repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p","secondary_identifier":"SGD:S000005913","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR386W"}


id: YOR387C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00161":null,"YOR387C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR387C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00161","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YOR387C has a paralog, VEL1, that arose from a single-locus duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005914","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR387C"}


id: YOR388C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FDH1","product":"NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate","secondary_identifier":"SGD:S000005915","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR388C"}


id: YOR389W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; expression regulated by copper levels","secondary_identifier":"SGD:S000005916","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR389W"}


id: YOR390W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01973":null,"YOR390W":null},"has_protein_features":false,"name":"FEX1","ortholog_annotations":[{"gene_uniquename":"YOR390W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01973","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in fluoride export; nearly identical to FEX2, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX domains connected by a linker; part of a widespread family of conserved fluoride export proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005917","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR390W"}


id: YOR391C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02988":null,"SJAG_04674":null,"YOR391C":null},"has_protein_features":false,"name":"HSP33","ortholog_annotations":[{"gene_uniquename":"YOR391C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02988","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR391C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04674","reference_uniquename":"PMID:29761456"}],"product":"Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005918","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR391C"}


id: YOR392W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; gene expression induced by heat","secondary_identifier":"SGD:S000005919","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR392W"}


id: YOR393W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00461":null,"SJAG_02107":null,"SJAG_02369":null,"YOR393W":null},"has_protein_features":false,"name":"ERR1","ortholog_annotations":[{"gene_uniquename":"YOR393W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00461","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR393W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02107","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR393W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02369","reference_uniquename":"PMID:29761456"}],"product":"Putative phosphopyruvate hydratase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005920","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR393W"}


id: YOR394C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028718","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR394C-A"}


id: YOR394W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU21","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cytosol; identical to Pau22p; encodes two proteins that are translated from 2 different start codons","secondary_identifier":"SGD:S000005921","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR394W"}


id: YOR396C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028719","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR396C-A"}


id: YOR396W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YRF1-8","product":"One of several telomeric Y' element-encoded DNA helicases; known as Y'-Help1 (Y'-HELicase Protein 1)","secondary_identifier":"SGD:S000007526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR396W"}


id: YPL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00676":null,"YPL001W":null},"has_protein_features":false,"name":"HAT1","ortholog_annotations":[{"gene_uniquename":"YPL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00676","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex; uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005922","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL001W"}


id: YPL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04936":null,"YPL002C":null},"has_protein_features":false,"name":"SNF8","ortholog_annotations":[{"gene_uniquename":"YPL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04936","reference_uniquename":"PMID:29761456"}],"product":"Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005923","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL002C"}


id: YPL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03950":null,"YPL003W":null},"has_protein_features":false,"name":"ULA1","ortholog_annotations":[{"gene_uniquename":"YPL003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03950","reference_uniquename":"PMID:29761456"}],"product":"Protein that activates Rub1p (NEDD8) before neddylation; acts together with Uba3p; may play a role in protein degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005924","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL003W"}


id: YPL004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02626":null,"SJAG_02707":null,"YPL004C":null},"has_protein_features":false,"name":"LSP1","ortholog_annotations":[{"gene_uniquename":"YPL004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02626","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02707","reference_uniquename":"PMID:29761456"}],"product":"Eisosome core component; eisosomes are large immobile patch structures at the cell cortex associated with endocytosis; phosphorylated on Thr233 upon Pkc1p hyperactivation in a Slt2p MAPK-dependent fashion; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005925","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL004C"}


id: YPL005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AEP3","product":"Peripheral mitochondrial inner membrane protein; may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; stabilizes the bicistronic AAP1-ATP6 mRNA","secondary_identifier":"SGD:S000005926","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL005W"}


id: YPL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NCR1","product":"Vacuolar membrane protein involved with Npc2p in sterol trafficking; transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCB), similar to the accumulation of high amounts of lipids observed in patients with Neimann-Pick C, a disease caused by loss-of-function mutations in NPC1, the functional ortholog of Ncr1p","secondary_identifier":"SGD:S000005927","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL006W"}


id: YPL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03546":null,"YPL007C":null},"has_protein_features":false,"name":"TFC8","ortholog_annotations":[{"gene_uniquename":"YPL007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03546","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005928","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL007C"}


id: YPL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01644":null,"YPL008W":null},"has_protein_features":false,"name":"CHL1","ortholog_annotations":[{"gene_uniquename":"YPL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01644","reference_uniquename":"PMID:29761456"}],"product":"Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005929","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL008W"}


id: YPL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01074":null,"YPL009C":null},"has_protein_features":false,"name":"RQC2","ortholog_annotations":[{"gene_uniquename":"YPL009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01074","reference_uniquename":"PMID:29761456"}],"product":"Component of the Ribosome Quality Control (RQC) complex;  RQC is a ribosome-bound complex required for degradation of polypeptides arising from stalled translation; recruits alanine- and threonine-charged tRNA to the A site and directs the elongation of nascent chains independently of mRNA or 40S subunits; monitors translation stress and signals this to Hsf1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005930","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL009C"}


id: YPL010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04474":null,"YPL010W":null},"has_protein_features":false,"name":"RET3","ortholog_annotations":[{"gene_uniquename":"YPL010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04474","reference_uniquename":"PMID:29761456"}],"product":"Zeta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005931","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL010W"}


id: YPL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04977":null,"YPL011C":null},"has_protein_features":false,"name":"TAF3","ortholog_annotations":[{"gene_uniquename":"YPL011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04977","reference_uniquename":"PMID:29761456"}],"product":"TFIID subunit (47 kDa); involved in promoter binding and RNA polymerase II transcription initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005932","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL011C"}


id: YPL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01323":null,"SJAG_04687":null,"YPL012W":null},"has_protein_features":false,"name":"RRP12","ortholog_annotations":[{"gene_uniquename":"YPL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01323","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04687","reference_uniquename":"PMID:29761456"}],"product":"Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; also plays a role in the cell cycle and the DNA damage response; contains HEAT-repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005933","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL012W"}


id: YPL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02324":null,"YPL013C":null},"has_protein_features":false,"name":"MRPS16","ortholog_annotations":[{"gene_uniquename":"YPL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02324","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005934","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL013C"}


id: YPL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CIP1","product":"Cyclin-dependent kinase inhibitor; activated by environmental stress; interacts with and inhibits the Cdc28p/Cln2p, G1/S phase cyclin-dependent kinase complex but not S-phase, or M-phase complexes; overexpression blocks cells in G1 phase and stabilizes the Cdc28p inhibitor Sic1p, while disruption accelerates the G1/S phase transition; phosphorylated during S phase in a Cdc28p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus","secondary_identifier":"SGD:S000005935","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL014W"}


id: YPL015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01075":null,"YPL015C":null},"has_protein_features":false,"name":"HST2","ortholog_annotations":[{"gene_uniquename":"YPL015C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01075","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic NAD(+)-dependent protein deacetylase; deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005936","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL015C"}


id: YPL016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02254":null,"YPL016W":null},"has_protein_features":false,"name":"SWI1","ortholog_annotations":[{"gene_uniquename":"YPL016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02254","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; self-assembles to form [SWI+] prion and to alter expression pattern; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005937","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL016W"}


id: YPL017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03290":null,"YPL017C":null},"has_protein_features":false,"name":"IRC15","ortholog_annotations":[{"gene_uniquename":"YPL017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03290","reference_uniquename":"PMID:26896847"}],"product":"Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci; IRC15 has a paralog, LPD1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000005938","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL017C"}


id: YPL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04040":null,"YPL018W":null},"has_protein_features":false,"name":"CTF19","ortholog_annotations":[{"gene_uniquename":"YPL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04040","reference_uniquename":"PMID:29761456"}],"product":"Outer kinetochore protein, needed for accurate chromosome segregation; component of kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as platform for kinetochore assembly; required for spindle assembly checkpoint; minimizes potentially deleterious centromere-proximal crossovers by preventing meiotic DNA break formation proximal to centromere; homolog of human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005939","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL018W"}


id: YPL019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03442":null,"YPL019C":null},"has_protein_features":false,"name":"VTC3","ortholog_annotations":[{"gene_uniquename":"YPL019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03442","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of the vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; VTC3 has a paralog, VTC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005940","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL019C"}


id: YPL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00776":null,"SJAG_02214":null,"YPL020C":null},"has_protein_features":false,"name":"ULP1","ortholog_annotations":[{"gene_uniquename":"YPL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00776","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02214","reference_uniquename":"PMID:29761456"}],"product":"Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; contributes to regulation of telomeric silencing; sequestered to the nucleolus under stress conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005941","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL020C"}


id: YPL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ECM23","product":"Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p","secondary_identifier":"SGD:S000005942","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL021W"}


id: YPL022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02556":null,"YPL022W":null},"has_protein_features":false,"name":"RAD1","ortholog_annotations":[{"gene_uniquename":"YPL022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02556","reference_uniquename":"PMID:29761456"}],"product":"Single-stranded DNA endonuclease (with Rad10p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005943","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL022W"}


id: YPL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01466":null,"YPL023C":null},"has_protein_features":false,"name":"MET12","ortholog_annotations":[{"gene_uniquename":"YPL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01466","reference_uniquename":"PMID:29761456"}],"product":"Protein with MTHFR activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of methylenetetrahydrofolate reductase (MTHFR)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005944","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL023C"}


id: YPL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02262":null,"YPL024W":null},"has_protein_features":false,"name":"RMI1","ortholog_annotations":[{"gene_uniquename":"YPL024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02262","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing, DNA catenation/decatenation and ssDNA binding activities of Top3p; involved in response to DNA damage; functions in S phase-mediated cohesion establishment via a pathway involving the Ctf18-RFC complex and Mrc1p; stimulates Top3p DNA catenation/decatenation activity; null mutants display increased rates of recombination and delayed S phase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005945","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL024W"}


id: YPL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005946","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL025C"}


id: YPL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01311":null,"YPL026C":null},"has_protein_features":false,"name":"SKS1","ortholog_annotations":[{"gene_uniquename":"YPL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01311","reference_uniquename":"PMID:29761456"}],"product":"Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway; SKS1 has a paralog, VHS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005947","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL026C"}


id: YPL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SMA1","product":"Protein of unknown function involved in prospore membrane assembly; involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p","secondary_identifier":"SGD:S000005948","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL027W"}


id: YPL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00413":null,"YPL028W":null},"has_protein_features":false,"name":"ERG10","ortholog_annotations":[{"gene_uniquename":"YPL028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00413","reference_uniquename":"PMID:29761456"}],"product":"Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase); cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis; human ACAT1 functionally complements the growth defect caused by repression of ERG10 expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005949","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL028W"}


id: YPL029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02991":null,"YPL029W":null},"has_protein_features":false,"name":"SUV3","ortholog_annotations":[{"gene_uniquename":"YPL029W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02991","reference_uniquename":"PMID:29761456"}],"product":"ATP-dependent RNA helicase; component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron; expression of a processed form of human homolog SUPV3L1 carrying an N-terminal deletion of 46 amino acids rescues yeast suv3 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005950","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL029W"}


id: YPL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03367":null,"YPL030W":null},"has_protein_features":false,"name":"TRM44","ortholog_annotations":[{"gene_uniquename":"YPL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03367","reference_uniquename":"PMID:29761456"}],"product":"tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005951","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL030W"}


id: YPL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01825":null,"YPL031C":null},"has_protein_features":false,"name":"PHO85","ortholog_annotations":[{"gene_uniquename":"YPL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01825","reference_uniquename":"PMID:29761456"}],"product":"Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissencephaly-associated homolog CDK5 functionally complements null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005952","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL031C"}


id: YPL032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02729":null,"SJAG_04591":null,"YPL032C":null},"has_protein_features":false,"name":"SVL3","ortholog_annotations":[{"gene_uniquename":"YPL032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02729","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04591","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress; SVL3 has a paralog, PAM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005953","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL032C"}


id: YPL033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SRL4","product":"Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p","secondary_identifier":"SGD:S000005954","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL033C"}


id: YPL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01350":null,"YPL034W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01350","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; YPL034W is not essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005955","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL034W"}


id: YPL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene","secondary_identifier":"SGD:S000005956","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL035C"}


id: YPL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01129":null,"SJAG_01669":null,"SJAG_04258":null,"YPL036W":null},"has_protein_features":false,"name":"PMA2","ortholog_annotations":[{"gene_uniquename":"YPL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01129","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01669","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04258","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane H+-ATPase; isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005957","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL036W"}


id: YPL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01733":null,"YPL037C":null},"has_protein_features":false,"name":"EGD1","ortholog_annotations":[{"gene_uniquename":"YPL037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01733","reference_uniquename":"PMID:29761456"}],"product":"Subunit beta1 of the nascent polypeptide-associated complex (NAC); involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b; EGD1 has a paralog, BTT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005958","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL037C"}


id: YPL038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MET31","product":"Zinc-finger DNA-binding transcription factor; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; involved in transcriptional regulation of the methionine biosynthetic genes; feedforward loop controlling expression of MET32 and the lack of such a loop for MET31 may account for the differential actions of Met31p and Met32p; MET31 has a paralog, MET32, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005959","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL038W"}


id: YPL038W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028588","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL038W-A"}


id: YPL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YPL039W is not an essential gene","secondary_identifier":"SGD:S000005960","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL039W"}


id: YPL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04285":null,"YPL040C":null},"has_protein_features":false,"name":"ISM1","ortholog_annotations":[{"gene_uniquename":"YPL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04285","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial isoleucyl-tRNA synthetase; null mutant is deficient in respiratory growth; human homolog IARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005961","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL040C"}


id: YPL041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MRX11","product":"Protein that associates with mitochondrial ribosome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; involved in maintenance of telomere length","secondary_identifier":"SGD:S000005962","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL041C"}


id: YPL042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00342":null,"YPL042C":null},"has_protein_features":false,"name":"SSN3","ortholog_annotations":[{"gene_uniquename":"YPL042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00342","reference_uniquename":"PMID:29761456"}],"product":"Component of the RNA polymerase II mediator complex; cyclin-dependent protein kinase involved in phosphorylation of the mediator component Pgd1p and suppression of transcription activation by RNA polymerase II; involved in glucose repression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005963","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL042C"}


id: YPL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02829":null,"YPL043W":null},"has_protein_features":false,"name":"NOP4","ortholog_annotations":[{"gene_uniquename":"YPL043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02829","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs); human ortholog RBM28 implicated in ANE syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005964","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL043W"}


id: YPL044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W","secondary_identifier":"SGD:S000005965","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL044C"}


id: YPL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01598":null,"YPL045W":null},"has_protein_features":false,"name":"VPS16","ortholog_annotations":[{"gene_uniquename":"YPL045W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01598","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the HOPS and the CORVET complexes; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005966","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL045W"}


id: YPL046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03211":null,"YPL046C":null},"has_protein_features":false,"name":"ELC1","ortholog_annotations":[{"gene_uniquename":"YPL046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03211","reference_uniquename":"PMID:29761456"}],"product":"Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005967","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL046C"}


id: YPL047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03599":null,"YPL047W":null},"has_protein_features":false,"name":"SGF11","ortholog_annotations":[{"gene_uniquename":"YPL047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03599","reference_uniquename":"PMID:29761456"}],"product":"Integral subunit of SAGA histone acetyltransferase complex; regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005968","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL047W"}


id: YPL048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02017":null,"SJAG_03863":null,"YPL048W":null},"has_protein_features":false,"name":"CAM1","ortholog_annotations":[{"gene_uniquename":"YPL048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02017","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03863","reference_uniquename":"PMID:29761456"}],"product":"One of two isoforms of the gamma subunit of eEF1B; stimulates the release of GDP from eEF1A (Tef1p/Tef2p) post association with the ribosomal complex with eEF1Balpha subunit; nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005969","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL048W"}


id: YPL049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DIG1","product":"MAP kinase-responsive inhibitor of the Ste12p transcription factor; involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p; DIG1 has a paralog, DIG2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005970","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL049C"}


id: YPL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01276":null,"YPL050C":null},"has_protein_features":false,"name":"MNN9","ortholog_annotations":[{"gene_uniquename":"YPL050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01276","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Golgi mannosyltransferase complex; this complex mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation; this complex also contains Anp1p, Mnn10p, Mnn11p, and Hoc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005971","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL050C"}


id: YPL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ARL3","product":"ARF-like small GTPase of the RAS superfamily; required for recruitment of Arl1p, a GTPase that regulates membrane traffic, to the Golgi apparatus; NatC-catalyzed N-terminal acetylation regulates Golgi membrane association mediated by interaction with membrane receptor, Sys1p; similar to ADP-ribosylation factor and orthologous to mammalian ARFRP1","secondary_identifier":"SGD:S000005972","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL051W"}


id: YPL052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OAZ1","product":"Regulator of ornithine decarboxylase Spe1p; antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p","secondary_identifier":"SGD:S000005973","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL052W"}


id: YPL052W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YPL052W-A has been demonstrated to be the first exon of downstream ORF OAZ1/YPL052W.","secondary_identifier":"SGD:S000113724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL052W-A"}


id: YPL053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"SJAG_04906":null,"YPL053C":null},"has_protein_features":false,"name":"KTR6","ortholog_annotations":[{"gene_uniquename":"YPL053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04906","reference_uniquename":"PMID:26896847"}],"product":"Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; facilitates the exit of Mnn4p from the ER via COPII-coated vesicles; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005974","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL053C"}


id: YPL054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01535":null,"SJAG_03191":null,"YPL054W":null},"has_protein_features":false,"name":"LEE1","ortholog_annotations":[{"gene_uniquename":"YPL054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01535","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03191","reference_uniquename":"PMID:29761456"}],"product":"Zinc-finger protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005975","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL054W"}


id: YPL055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00320":null,"YPL055C":null},"has_protein_features":false,"name":"LGE1","ortholog_annotations":[{"gene_uniquename":"YPL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00320","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in histone H2B ubiquitination; acts as cofactor for Bre1p; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005976","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL055C"}


id: YPL056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LCL1","product":"Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan","secondary_identifier":"SGD:S000005977","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL056C"}


id: YPL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02168":null,"SJAG_03953":null,"YPL057C":null},"has_protein_features":false,"name":"SUR1","ortholog_annotations":[{"gene_uniquename":"YPL057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02168","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03953","reference_uniquename":"PMID:29761456"}],"product":"Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005978","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL057C"}


id: YPL058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04277":null,"YPL058C":null},"has_protein_features":false,"name":"PDR12","ortholog_annotations":[{"gene_uniquename":"YPL058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane ATP-binding cassette (ABC) transporter; weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005979","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL058C"}


id: YPL059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01417":null,"YPL059W":null},"has_protein_features":false,"name":"GRX5","ortholog_annotations":[{"gene_uniquename":"YPL059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01417","reference_uniquename":"PMID:29761456"}],"product":"Glutathione-dependent oxidoreductase; mitochondrial matrix protein involved at an early step in the biogenesis of iron-sulfur centers along with Bol1p; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005980","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL059W"}


id: YPL060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01639":null,"YPL060W":null},"has_protein_features":false,"name":"MFM1","ortholog_annotations":[{"gene_uniquename":"YPL060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01639","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005981","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL060W"}


id: YPL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03786":null,"YPL061W":null},"has_protein_features":false,"name":"ALD6","ortholog_annotations":[{"gene_uniquename":"YPL061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03786","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic aldehyde dehydrogenase; activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005982","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL061W"}


id: YPL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; deletion decreases transcription of downstream gene ALD6; YPL062W is not an essential gene; null mutant shows decrease in terpenoid production; homozygous diploid mutant shows a decrease in glycogen accumulation","secondary_identifier":"SGD:S000005983","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL062W"}


id: YPL063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03560":null,"YPL063W":null},"has_protein_features":false,"name":"TIM50","ortholog_annotations":[{"gene_uniquename":"YPL063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03560","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the TIM23 complex; acts as receptor for the translocase of the inner mitochondrial membrane (TIM23) complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005984","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL063W"}


id: YPL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00602":null,"YPL064C":null},"has_protein_features":false,"name":"CWC27","ortholog_annotations":[{"gene_uniquename":"YPL064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00602","reference_uniquename":"PMID:29761456"}],"product":"Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005985","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL064C"}


id: YPL065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04349":null,"YPL065W":null},"has_protein_features":false,"name":"VPS28","ortholog_annotations":[{"gene_uniquename":"YPL065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04349","reference_uniquename":"PMID:29761456"}],"product":"Component of the ESCRT-I complex; complex is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p; other members include Stp22p, Srn2p, Vps28p, and Mvb12p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005986","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL065W"}


id: YPL066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02215":null,"YPL066W":null},"has_protein_features":false,"name":"RGL1","ortholog_annotations":[{"gene_uniquename":"YPL066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02215","reference_uniquename":"PMID:29761456"}],"product":"Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005987","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL066W"}


id: YPL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HTC1","product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene","secondary_identifier":"SGD:S000005988","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL067C"}


id: YPL068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000005989","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL068C"}


id: YPL069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BTS1","product":"Geranylgeranyl diphosphate synthase (GGPPS); increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic","secondary_identifier":"SGD:S000005990","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL069C"}


id: YPL070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MUK1","product":"Guanine nucleotide exchange factor (GEF); involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); specifically stimulates the intrinsic guanine nucleotide exchange activity of Rab family members (Vps21p/Ypt52p/Ypt53p); partially redundant with GEF VPS9; required for localization of the CORVET complex to endosomes; contains a VPS9 domain","secondary_identifier":"SGD:S000005991","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL070W"}


id: YPL071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","secondary_identifier":"SGD:S000005992","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL071C"}


id: YPL072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01312":null,"YPL072W":null},"has_protein_features":false,"name":"UBP16","ortholog_annotations":[{"gene_uniquename":"YPL072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01312","reference_uniquename":"PMID:29761456"}],"product":"Deubiquitinating enzyme anchored to the outer mitochondrial membrane; probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005993","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL072W"}


id: YPL073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments","secondary_identifier":"SGD:S000005994","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL073C"}


id: YPL074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01530":null,"SJAG_04566":null,"YPL074W":null},"has_protein_features":false,"name":"YTA6","ortholog_annotations":[{"gene_uniquename":"YPL074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01530","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04566","reference_uniquename":"PMID:29761456"}],"product":"Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005995","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL074W"}


id: YPL075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GCR1","product":"Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p; contains a long intron, which allows multiple RNA and protein isoforms with varying expression levels depending on glucose availability","secondary_identifier":"SGD:S000005996","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL075W"}


id: YPL076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04119":null,"YPL076W":null},"has_protein_features":false,"name":"GPI2","ortholog_annotations":[{"gene_uniquename":"YPL076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04119","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005997","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL076W"}


id: YPL077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005998","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL077C"}


id: YPL078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00836":null,"YPL078C":null},"has_protein_features":false,"name":"ATP4","ortholog_annotations":[{"gene_uniquename":"YPL078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00836","reference_uniquename":"PMID:29761456"}],"product":"Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase; ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex, which in turn determines the shape of inner membrane cristae; phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005999","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL078C"}


id: YPL079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00155":null,"SJAG_01202":null,"YPL079W":null},"has_protein_features":false,"name":"RPL21B","ortholog_annotations":[{"gene_uniquename":"YPL079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00155","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01202","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006000","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL079W"}


id: YPL080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000006001","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL080C"}


id: YPL081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00544":null,"SJAG_04342":null,"YPL081W":null},"has_protein_features":false,"name":"RPS9A","ortholog_annotations":[{"gene_uniquename":"YPL081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00544","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04342","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006002","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL081W"}


id: YPL082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00650":null,"YPL082C":null},"has_protein_features":false,"name":"MOT1","ortholog_annotations":[{"gene_uniquename":"YPL082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00650","reference_uniquename":"PMID:29761456"}],"product":"Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity; may have a role in ensuring that soluble TBP is available to bind TATA-less promoters; forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA; coregulates transcription with Spt16p through assembly of preinitiation complex and organization of nucleosomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006003","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL082C"}


id: YPL083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00754":null,"YPL083C":null},"has_protein_features":false,"name":"SEN54","ortholog_annotations":[{"gene_uniquename":"YPL083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00754","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006004","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL083C"}


id: YPL084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02584":null,"YPL084W":null},"has_protein_features":false,"name":"BRO1","ortholog_annotations":[{"gene_uniquename":"YPL084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02584","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic class E vacuolar protein sorting (VPS) factor; coordinates protein sorting and deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006005","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL084W"}


id: YPL085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00284":null,"YPL085W":null},"has_protein_features":false,"name":"SEC16","ortholog_annotations":[{"gene_uniquename":"YPL085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00284","reference_uniquename":"PMID:29761456"}],"product":"COPII vesicle coat protein required for ER transport vesicle budding; essential factor in endoplasmic reticulum exit site (ERES) formation, as well as in COPII-mediated ER-to-Golgi traffic; bound to periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006006","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL085W"}


id: YPL086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04756":null,"YPL086C":null},"has_protein_features":false,"name":"ELP3","ortholog_annotations":[{"gene_uniquename":"YPL086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04756","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin; human homolog ELP3 can partially complement yeast elp3 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006007","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL086C"}


id: YPL087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YDC1","product":"Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006008","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL087W"}


id: YPL088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative aryl alcohol dehydrogenase; localizes to cytosol; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance","secondary_identifier":"SGD:S000006009","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL088W"}


id: YPL089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02218":null,"SJAG_04191":null,"YPL089C":null},"has_protein_features":false,"name":"RLM1","ortholog_annotations":[{"gene_uniquename":"YPL089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02218","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04191","reference_uniquename":"PMID:29761456"}],"product":"MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006010","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL089C"}


id: YPL090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03034":null,"SJAG_03859":null,"YPL090C":null},"has_protein_features":false,"name":"RPS6A","ortholog_annotations":[{"gene_uniquename":"YPL090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03859","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006011","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL090C"}


id: YPL091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01162":null,"YPL091W":null},"has_protein_features":false,"name":"GLR1","ortholog_annotations":[{"gene_uniquename":"YPL091W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01162","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; cytosolic Glr1p is the main determinant of the glutathione redox state of the mitochondrial intermembrane space; mitochondrial Glr1p has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006012","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL091W"}


id: YPL092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SSU1","product":"Plasma membrane sulfite pump involved in sulfite metabolism; required for efficient sulfite efflux; major facilitator superfamily protein","secondary_identifier":"SGD:S000006013","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL092W"}


id: YPL093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04940":null,"YPL093W":null},"has_protein_features":false,"name":"NOG1","ortholog_annotations":[{"gene_uniquename":"YPL093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04940","reference_uniquename":"PMID:29761456"}],"product":"Putative GTPase; associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006014","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL093W"}


id: YPL094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02588":null,"YPL094C":null},"has_protein_features":false,"name":"SEC62","ortholog_annotations":[{"gene_uniquename":"YPL094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02588","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; cotranslationally N-acetylated by NatA; other members are Sec63p, Sec66p, and Sec72p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006015","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL094C"}


id: YPL095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"EEB1","product":"Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006016","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL095C"}


id: YPL096C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06383":null,"YPL096C-A":null},"has_protein_features":false,"name":"ERI1","ortholog_annotations":[{"gene_uniquename":"YPL096C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06383","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum membrane protein that binds and inhibits Ras2p; binds to and inhibits GTP-bound Ras2p at the endoplasmic reticulum (ER); component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL096C-A"}


id: YPL096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03227":null,"YPL096W":null},"has_protein_features":false,"name":"PNG1","ortholog_annotations":[{"gene_uniquename":"YPL096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03227","reference_uniquename":"PMID:29761456"}],"product":"Conserved peptide N-glycanase; deglycosylating enzyme that cleaves N-glycans that are attached to misfolded ERAD substrate glycoproteins prior to proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p; human ortholog NGLY1 is associated with a syndrome characterized by developmental delays, epilepsy, absence of tears and liver disease","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006017","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL096W"}


id: YPL097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04473":null,"YPL097W":null},"has_protein_features":false,"name":"MSY1","ortholog_annotations":[{"gene_uniquename":"YPL097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04473","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial tyrosyl-tRNA synthetase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006018","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL097W"}


id: YPL098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01120":null,"YPL098C":null},"has_protein_features":false,"name":"MGR2","ortholog_annotations":[{"gene_uniquename":"YPL098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01120","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; provides quality control for insertion of membrane proteins by regulating their release into the inner membrane by the TIM23 complex; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006019","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL098C"}


id: YPL099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_07008":null,"YPL099C":null},"has_protein_features":false,"name":"INA17","ortholog_annotations":[{"gene_uniquename":"YPL099C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07008","reference_uniquename":"PMID:29761456"}],"product":"F1F0 ATPase synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex (Ina22p-Ina17p) involved in assembly of the F1F0 peripheral stalk; co-purifies with Ina22p and ATP synthase subunits; null mutant displays elevated frequency of mitochondrial genome loss and has a respiratory growth defect","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006020","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL099C"}


id: YPL100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATG21","product":"Phosphoinositide binding protein; required for vesicle formation in the cytoplasm-to-vacuole targeting (CVT) pathway, autophagy, micronucleophagy and mitophagy; binds to several phosphoinositides including: PtdIns(3,5)P2, PI3P and PI4P; involved in PI3P-dependent recruitment and organization of both the Atg12-Atg5-Atg16 complex and Atg8p at the pre-autophagosomal structure; necessary for oxidant-induced cell death; WD-40 repeat containing PROPPIN family member","secondary_identifier":"SGD:S000006021","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL100W"}


id: YPL101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03677":null,"YPL101W":null},"has_protein_features":false,"name":"ELP4","ortholog_annotations":[{"gene_uniquename":"YPL101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03677","reference_uniquename":"PMID:29761456"}],"product":"Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; null mutation is functionally complemented by human ELP4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006022","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL101W"}


id: YPL102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4","secondary_identifier":"SGD:S000006023","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL102C"}


id: YPL103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FMP30","product":"Protein with a role in maintaining mitochondrial morphology; also involved in maintaining normal cardiolipin levels; mitochondrial inner membrane protein; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D","secondary_identifier":"SGD:S000006024","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL103C"}


id: YPL104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04094":null,"YPL104W":null},"has_protein_features":false,"name":"MSD1","ortholog_annotations":[{"gene_uniquename":"YPL104W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04094","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial aspartyl-tRNA synthetase; required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006025","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL104W"}


id: YPL105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01279":null,"YPL105C":null},"has_protein_features":false,"name":"SYH1","ortholog_annotations":[{"gene_uniquename":"YPL105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01279","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006026","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL105C"}


id: YPL106C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04511":null,"YPL106C":null},"has_protein_features":false,"name":"SSE1","ortholog_annotations":[{"gene_uniquename":"YPL106C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04511","reference_uniquename":"PMID:29761456"}],"product":"ATPase component of heat shock protein Hsp90 chaperone complex; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; plays a role in prion propagation and determining prion variants; binds unfolded proteins; member of Hsp110 subclass of HSP70 proteins; deletion results in spindle elongation in S phase; SSE1 has a paralog, SSE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006027","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL106C"}


id: YPL107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02559":null,"YPL107W":null},"has_protein_features":false,"name":"DPC25","ortholog_annotations":[{"gene_uniquename":"YPL107W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02559","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; DPC25 is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006028","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL107W"}


id: YPL108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000006029","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL108W"}


id: YPL109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00496":null,"YPL109C":null},"has_protein_features":false,"name":"CQD1","ortholog_annotations":[{"gene_uniquename":"YPL109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00496","reference_uniquename":"PMID:29761456"}],"product":"UbiB family mitochondrial protein; involved in mobilization of CoQ from its site of synthesis on the inner mitochondrial membrane to other sites of action; contains transmembrane domain and mitochondrial targeting sequence","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006030","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL109C"}


id: YPL110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00622":null,"YPL110C":null},"has_protein_features":false,"name":"GDE1","ortholog_annotations":[{"gene_uniquename":"YPL110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00622","reference_uniquename":"PMID:29761456"}],"product":"Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006031","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL110C"}


id: YPL111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03398":null,"YPL111W":null},"has_protein_features":false,"name":"CAR1","ortholog_annotations":[{"gene_uniquename":"YPL111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03398","reference_uniquename":"PMID:29761456"}],"product":"Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006032","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL111W"}


id: YPL112C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEX25","product":"Peripheral peroxisomal membrane peroxin; required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with Pex27p; PEX25 has a paralog, PEX27, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006033","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL112C"}


id: YPL113C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene","secondary_identifier":"SGD:S000006034","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL113C"}


id: YPL114W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index","secondary_identifier":"SGD:S000006035","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL114W"}


id: YPL115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02278":null,"YPL115C":null},"has_protein_features":false,"name":"BEM3","ortholog_annotations":[{"gene_uniquename":"YPL115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02278","reference_uniquename":"PMID:29761456"}],"product":"Rho GTPase activating protein (RhoGAP); involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006036","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL115C"}


id: YPL116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HOS3","product":"Trichostatin A-insensitive homodimeric histone deacetylase (HDAC); specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats","secondary_identifier":"SGD:S000006037","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL116W"}


id: YPL117C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04307":null,"YPL117C":null},"has_protein_features":false,"name":"IDI1","ortholog_annotations":[{"gene_uniquename":"YPL117C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04307","reference_uniquename":"PMID:29761456"}],"product":"Isopentenyl diphosphate:dimethylallyl diphosphate isomerase; catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability; isopentenyl diphosphate:dimethylallyl diphosphate isomerase is also known as IPP isomerase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006038","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL117C"}


id: YPL118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00105":null,"SJAG_02201":null,"YPL118W":null},"has_protein_features":false,"name":"MRP51","ortholog_annotations":[{"gene_uniquename":"YPL118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00105","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02201","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006039","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL118W"}


id: YPL119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00786":null,"YPL119C":null},"has_protein_features":false,"name":"DBP1","ortholog_annotations":[{"gene_uniquename":"YPL119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00786","reference_uniquename":"PMID:29761456"}],"product":"ATP-dependent RNA helicase of the DEAD-box protein family; accelerates eIF4F-dependent assembly of 48S translation preinitiation complex (PIC), stimulating recruitment of mRNAs with long, structured 5'-UTRs; cooperates with DEAD-box RNA helicase and paralog Ded1p, stimulating PIC attachment and highly processive scanning by the 40S ribosomal subunit; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006040","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL119C"}


id: YPL119C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028859","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL119C-A"}


id: YPL120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01876":null,"YPL120W":null},"has_protein_features":false,"name":"VPS30","ortholog_annotations":[{"gene_uniquename":"YPL120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01876","reference_uniquename":"PMID:29761456"}],"product":"Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy, Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has novel globular fold essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of higher eukaryote gene Beclin 1; human BECN1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006041","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL120W"}


id: YPL121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01495":null,"SJAG_01708":null,"YPL121C":null},"has_protein_features":false,"name":"MEI5","ortholog_annotations":[{"gene_uniquename":"YPL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01495","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01708","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006042","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL121C"}


id: YPL122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00901":null,"YPL122C":null},"has_protein_features":false,"name":"TFB2","ortholog_annotations":[{"gene_uniquename":"YPL122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00901","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006043","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL122C"}


id: YPL123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RNY1","product":"Vacuolar RNase of the T(2) family; relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; required for tRNA-specific translational pausing during oxidative stress; promotes apoptosis under stress conditions and this function is independent of Rny1p catalytic activity","secondary_identifier":"SGD:S000006044","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL123C"}


id: YPL124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPC29","product":"Inner plaque spindle pole body (SPB) component; links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication","secondary_identifier":"SGD:S000006045","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL124W"}


id: YPL125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01083":null,"YPL125W":null},"has_protein_features":false,"name":"KAP120","ortholog_annotations":[{"gene_uniquename":"YPL125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01083","reference_uniquename":"PMID:29761456"}],"product":"Karyopherin responsible for the nuclear import of Rpf1p; Rpf1p is a ribosome maturation factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006046","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL125W"}


id: YPL126W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01764":null,"YPL126W":null},"has_protein_features":false,"name":"NAN1","ortholog_annotations":[{"gene_uniquename":"YPL126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01764","reference_uniquename":"PMID:29761456"}],"product":"U3 snoRNP protein; component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006047","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL126W"}


id: YPL127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HHO1","product":"Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination","secondary_identifier":"SGD:S000006048","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL127C"}


id: YPL128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02212":null,"YPL128C":null},"has_protein_features":false,"name":"TBF1","ortholog_annotations":[{"gene_uniquename":"YPL128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02212","reference_uniquename":"PMID:29761456"}],"product":"Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006049","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL128C"}


id: YPL129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00735":null,"YPL129W":null},"has_protein_features":false,"name":"TAF14","ortholog_annotations":[{"gene_uniquename":"YPL129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00735","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006050","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL129W"}


id: YPL130W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPO19","product":"Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation; SPO19 has a paralog, YOR214C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006051","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL130W"}


id: YPL131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01568":null,"SJAG_04066":null,"YPL131W":null},"has_protein_features":false,"name":"RPL5","ortholog_annotations":[{"gene_uniquename":"YPL131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01568","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04066","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L5; nascent Rpl5p is bound by specific chaperone Syo1p during translation; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006052","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL131W"}


id: YPL132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03322":null,"YPL132W":null},"has_protein_features":false,"name":"COX11","ortholog_annotations":[{"gene_uniquename":"YPL132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03322","reference_uniquename":"PMID:29761456"}],"product":"Protein required for delivery of copper to Cox1p; mitochondrial inner membrane protein; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006053","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL132W"}


id: YPL133C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RDS2","product":"Transcription factor involved in regulating gluconeogenesis; also involved in the regulation of glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole","secondary_identifier":"SGD:S000006054","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL133C"}


id: YPL134C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00522":null,"YPL134C":null},"has_protein_features":false,"name":"ODC1","ortholog_annotations":[{"gene_uniquename":"YPL134C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00522","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation; ODC1 has a paralog, ODC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006055","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL134C"}


id: YPL135C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028720","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL135C-A"}


id: YPL135W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00532":null,"YPL135W":null},"has_protein_features":false,"name":"ISU1","ortholog_annotations":[{"gene_uniquename":"YPL135W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00532","reference_uniquename":"PMID:29761456"}],"product":"Conserved protein of the mitochondrial matrix; performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); ISU1 has a paralog, ISU2, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006056","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL135W"}


id: YPL136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C","secondary_identifier":"SGD:S000006057","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL136W"}


id: YPL137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GIP3","product":"Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006058","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL137C"}


id: YPL138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01325":null,"YPL138C":null},"has_protein_features":false,"name":"SPP1","ortholog_annotations":[{"gene_uniquename":"YPL138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01325","reference_uniquename":"PMID:29761456"}],"product":"Subunit of COMPASS (Set1C); a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; promotes meiotic DSB formation by interacting with H3K4me3 and Rec107p, a protein required for Spo11p-catalyzed DSB formation located on chromosome axes; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein; relocalizes to cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006059","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL138C"}


id: YPL139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04758":null,"YPL139C":null},"has_protein_features":false,"name":"UME1","ortholog_annotations":[{"gene_uniquename":"YPL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04758","reference_uniquename":"PMID:29761456"}],"product":"Component of both the Rpd3S and Rpd3L histone deacetylase complexes; negative regulator of meiosis; required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p; UME1 has a paralog, WTM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006060","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL139C"}


id: YPL140C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01181":null,"YPL140C":null},"has_protein_features":false,"name":"MKK2","ortholog_annotations":[{"gene_uniquename":"YPL140C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01181","reference_uniquename":"PMID:29761456"}],"product":"MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006061","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL140C"}


id: YPL141C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04507":null,"YPL141C":null},"has_protein_features":false,"name":"FRK1","ortholog_annotations":[{"gene_uniquename":"YPL141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04507","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006062","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL141C"}


id: YPL142C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit","secondary_identifier":"SGD:S000006063","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL142C"}


id: YPL143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00166":null,"SJAG_04414":null,"YPL143W":null},"has_protein_features":false,"name":"RPL33A","ortholog_annotations":[{"gene_uniquename":"YPL143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00166","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04414","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006064","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL143W"}


id: YPL144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04197":null,"YPL144W":null},"has_protein_features":false,"name":"POC4","ortholog_annotations":[{"gene_uniquename":"YPL144W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04197","reference_uniquename":"PMID:29761456"}],"product":"Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006065","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL144W"}


id: YPL145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01590":null,"SJAG_02323":null,"SJAG_02375":null,"SJAG_03718":null,"YPL145C":null},"has_protein_features":false,"name":"KES1","ortholog_annotations":[{"gene_uniquename":"YPL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01590","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02323","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02375","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03718","reference_uniquename":"PMID:29761456"}],"product":"Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger; one of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006066","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL145C"}


id: YPL146C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00323":null,"YPL146C":null},"has_protein_features":false,"name":"NOP53","ortholog_annotations":[{"gene_uniquename":"YPL146C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00323","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p and with the nucleolar proteins Nop17p and Nip7p; null mutant is viable but growth is severely impaired","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006067","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL146C"}


id: YPL147W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PXA1","product":"Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant","secondary_identifier":"SGD:S000006068","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL147W"}


id: YPL148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03180":null,"YPL148C":null},"has_protein_features":false,"name":"PPT2","ortholog_annotations":[{"gene_uniquename":"YPL148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03180","reference_uniquename":"PMID:29761456"}],"product":"Phosphopantetheine:protein transferase (PPTase); activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006069","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL148C"}


id: YPL149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00059":null,"YPL149W":null},"has_protein_features":false,"name":"ATG5","ortholog_annotations":[{"gene_uniquename":"YPL149W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00059","reference_uniquename":"PMID:29761456"}],"product":"Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3 by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; also involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006070","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL149W"}


id: YPL150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02760":null,"YPL150W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPL150W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02760","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006071","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL150W"}


id: YPL151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04694":null,"YPL151C":null},"has_protein_features":false,"name":"PRP46","ortholog_annotations":[{"gene_uniquename":"YPL151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04694","reference_uniquename":"PMID:29761456"}],"product":"Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006072","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL151C"}


id: YPL152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00078":null,"YPL152W":null},"has_protein_features":false,"name":"RRD2","ortholog_annotations":[{"gene_uniquename":"YPL152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00078","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006073","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL152W"}


id: YPL152W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028721","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL152W-A"}


id: YPL153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04287":null,"YPL153C":null},"has_protein_features":false,"name":"RAD53","ortholog_annotations":[{"gene_uniquename":"YPL153C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04287","reference_uniquename":"PMID:29761456"}],"product":"DNA damage response kinase; signal transduction pathway component required for DNA damage and replication checkpoints, promoting cell cycle arrest and DNA repair; role in initiation of DNA replication; inhibits gene gating through NPC protein phosphorylation, to promote fork stability; activates downstream kinase Dun1p; senses mtDNA depletion and mitochondrial ROS; relocalizes to cytosol under hypoxia; contains two FHA domains; human homolog CHEK2 implicated in breast cancer complements the null","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006074","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL153C"}


id: YPL154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEP4","product":"Vacuolar aspartyl protease (proteinase A); required for posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; plays a protective role in acetic acid induced apoptosis; synthesized as a zymogen, self-activates","secondary_identifier":"SGD:S000006075","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL154C"}


id: YPL155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00851":null,"SJAG_01297":null,"SJAG_02336":null,"YPL155C":null},"has_protein_features":false,"name":"KIP2","ortholog_annotations":[{"gene_uniquename":"YPL155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00851","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01297","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02336","reference_uniquename":"PMID:26896847"}],"product":"Kinesin-related motor protein involved in mitotic spindle positioning; stabilizes microtubules by targeting Bik1p to the plus end; functions as a microtubule polymerase and catastrophe inhibitor in vitro; Kip2p levels are controlled during the cell cycle","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006076","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL155C"}


id: YPL156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PRM4","product":"Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift","secondary_identifier":"SGD:S000006077","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL156C"}


id: YPL157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03901":null,"YPL157W":null},"has_protein_features":false,"name":"TGS1","ortholog_annotations":[{"gene_uniquename":"YPL157W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03901","reference_uniquename":"PMID:29761456"}],"product":"Trimethyl guanosine synthase, conserved nucleolar methyl transferase; converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs; interacts with Swm2p, which may confer substrate specificity on Tgs1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006078","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL157W"}


id: YPL158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AIM44","product":"Regulator of Cdc42p and Rho1p; regulates AMR closure through Hof1p; inhibits Cdc42-dependent Cla4 activation at the division site, to prevent budding in the old bud neck; recruits Nis1p and Nba1p to the division site with Nap1 and the Rax1p-Rax2p dependent inheritance of Nis1p and Nba1p to bud scars to prevent division site repolarization; keeps Rho1p at the division site after AMR contraction to control secondary septum formation; relocalizes from bud neck to cytoplasm upon replication stress","secondary_identifier":"SGD:S000006079","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL158C"}


id: YPL159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PET20","product":"Mitochondrial protein; required for respiratory growth under some conditions and for stability of the mitochondrial genome; subunit of a complex containing Mrx6p, Pim1p, and Mam33p that may regulate mtDNA replication","secondary_identifier":"SGD:S000006080","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL159C"}


id: YPL160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02015":null,"YPL160W":null},"has_protein_features":false,"name":"CDC60","ortholog_annotations":[{"gene_uniquename":"YPL160W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02015","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic leucyl tRNA synthetase; ligates leucine to the appropriate tRNA; human homolog LARS can complement yeast temperature-sensitive mutant at restrictive temperature","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006081","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL160W"}


id: YPL161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04653":null,"YPL161C":null},"has_protein_features":false,"name":"BEM4","ortholog_annotations":[{"gene_uniquename":"YPL161C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04653","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006082","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL161C"}


id: YPL162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology","secondary_identifier":"SGD:S000006083","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL162C"}


id: YPL163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SVS1","product":"Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006084","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL163C"}


id: YPL164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MLH3","product":"Protein involved in DNA mismatch repair and meiotic recombination; involved in crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability","secondary_identifier":"SGD:S000006085","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL164C"}


id: YPL165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02659":null,"YPL165C":null},"has_protein_features":false,"name":"SET6","ortholog_annotations":[{"gene_uniquename":"YPL165C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02659","reference_uniquename":"PMID:29761456"}],"product":"SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006086","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL165C"}


id: YPL166W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATG29","product":"Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","secondary_identifier":"SGD:S000006087","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL166W"}


id: YPL167C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00153":null,"YPL167C":null},"has_protein_features":false,"name":"REV3","ortholog_annotations":[{"gene_uniquename":"YPL167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00153","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; may be involved in meiosis; forms a complex with Rev7p, Pol31p and Pol32p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006088","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL167C"}


id: YPL168W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MRX4","product":"Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated","secondary_identifier":"SGD:S000006089","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL168W"}


id: YPL169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00178":null,"YPL169C":null},"has_protein_features":false,"name":"MEX67","ortholog_annotations":[{"gene_uniquename":"YPL169C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00178","reference_uniquename":"PMID:29761456"}],"product":"Poly(A)RNA binding protein involved in nuclear mRNA export; component of the nuclear pore; ortholog of human TAP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006090","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL169C"}


id: YPL170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02982":null,"YPL170W":null},"has_protein_features":false,"name":"DAP1","ortholog_annotations":[{"gene_uniquename":"YPL170W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02982","reference_uniquename":"PMID:29761456"}],"product":"Heme-binding protein; involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006091","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL170W"}


id: YPL171C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OYE3","product":"Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death","secondary_identifier":"SGD:S000006092","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL171C"}


id: YPL172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03173":null,"YPL172C":null},"has_protein_features":false,"name":"COX10","ortholog_annotations":[{"gene_uniquename":"YPL172C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03173","reference_uniquename":"PMID:29761456"}],"product":"Heme A:farnesyltransferase; catalyzes first step in conversion of protoheme to heme A prosthetic group required for cytochrome c oxidase activity; human ortholog COX10 can complement yeast cox10 null mutant; human ortholog COX10 is associated with mitochondrial disorders","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006093","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL172C"}


id: YPL173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04490":null,"YPL173W":null},"has_protein_features":false,"name":"MRPL40","ortholog_annotations":[{"gene_uniquename":"YPL173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04490","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006094","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL173W"}


id: YPL174C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00140":null,"YPL174C":null},"has_protein_features":false,"name":"NIP100","ortholog_annotations":[{"gene_uniquename":"YPL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00140","reference_uniquename":"PMID:29761456"}],"product":"Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006095","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL174C"}


id: YPL175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04881":null,"YPL175W":null},"has_protein_features":false,"name":"SPT14","ortholog_annotations":[{"gene_uniquename":"YPL175W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04881","reference_uniquename":"PMID:29761456"}],"product":"UDP-glycosyltransferase subunit of the GPI-GnT complex; UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006096","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL175W"}


id: YPL176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02117":null,"YPL176C":null},"has_protein_features":false,"name":"TRE1","ortholog_annotations":[{"gene_uniquename":"YPL176C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02117","reference_uniquename":"PMID:29761456"}],"product":"Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitination and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006097","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL176C"}


id: YPL177C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CUP9","product":"Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000006098","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL177C"}


id: YPL178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01064":null,"YPL178W":null},"has_protein_features":false,"name":"CBC2","ortholog_annotations":[{"gene_uniquename":"YPL178W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01064","reference_uniquename":"PMID:29761456"}],"product":"Small subunit of the heterodimeric cap binding complex with Sto1p; interacts with Npl3p, possibly to package mRNA for export from the nucleus; may have a role in telomere maintenance; contains an RNA-binding motif","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006099","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL178W"}


id: YPL179W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04426":null,"YPL179W":null},"has_protein_features":false,"name":"PPQ1","ortholog_annotations":[{"gene_uniquename":"YPL179W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04426","reference_uniquename":"PMID:29761456"}],"product":"Protein phosphatase that regulates the mating response; negatively regulates the MAP kinase signaling cascade during mating; member of the serine/threonine phosphatase PP1 family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006100","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL179W"}


id: YPL180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01703":null,"YPL180W":null},"has_protein_features":false,"name":"TCO89","ortholog_annotations":[{"gene_uniquename":"YPL180W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01703","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p); regulates global H3K56ac; TORC1 complex regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006101","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL180W"}


id: YPL181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03255":null,"YPL181W":null},"has_protein_features":false,"name":"CTI6","ortholog_annotations":[{"gene_uniquename":"YPL181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03255","reference_uniquename":"PMID:29761456"}],"product":"Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006102","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL181W"}


id: YPL182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W","secondary_identifier":"SGD:S000006103","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL182C"}


id: YPL183C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02352":null,"YPL183C":null},"has_protein_features":false,"name":"RTT10","ortholog_annotations":[{"gene_uniquename":"YPL183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02352","reference_uniquename":"PMID:29761456"}],"product":"WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006104","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL183C"}


id: YPL183W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03040":null,"YPL183W-A":null},"has_protein_features":false,"name":"RTC6","ortholog_annotations":[{"gene_uniquename":"YPL183W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03040","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL183W-A"}


id: YPL184C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MRN1","product":"RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation","secondary_identifier":"SGD:S000006105","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL184C"}


id: YPL185W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C","secondary_identifier":"SGD:S000006106","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL185W"}


id: YPL186C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"UIP4","product":"Protein that interacts with Ulp1p; a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope","secondary_identifier":"SGD:S000006107","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL186C"}


id: YPL187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MF(ALPHA)1","product":"Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor; binds copper(II) ions","secondary_identifier":"SGD:S000006108","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL187W"}


id: YPL188W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03946":null,"YPL188W":null},"has_protein_features":false,"name":"POS5","ortholog_annotations":[{"gene_uniquename":"YPL188W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03946","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial NADH kinase; phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006109","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL188W"}


id: YPL189C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COA2","product":"Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p","secondary_identifier":"SGD:S000028527","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL189C-A"}


id: YPL189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04337":null,"YPL189W":null},"has_protein_features":false,"name":"GUP2","ortholog_annotations":[{"gene_uniquename":"YPL189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04337","reference_uniquename":"PMID:29761456"}],"product":"Probable membrane protein; possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; homolog of the mammalian Hedgehog pathway modulator HHAT; GUP2 has a paralog, GUP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006110","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL189W"}


id: YPL190C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03747":null,"YPL190C":null},"has_protein_features":false,"name":"NAB3","ortholog_annotations":[{"gene_uniquename":"YPL190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03747","reference_uniquename":"PMID:29761456"}],"product":"RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing; Nrd1-Nab3 pathway appears to have a role in rapid suppression of some genes when cells are shifted to poor growth conditions, indicating role for Nrd1-Nab3 in regulating cellular response to nutrient availability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006111","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL190C"}


id: YPL191C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01481":null,"YPL191C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPL191C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01481","reference_uniquename":"PMID:29761456"}],"product":"K48-specific deubiquitinating (DUB) enzyme; MINDY family endo-type deubiquitinase that preferentially cleaves long K48-linked polyubiquitin chains between moieties; diploid deletion strain exhibits high budding index; GFP-fusion protein localizes to the cytoplasm endoplasmic reticulum and cell periphery in high-throughput studies; YPL191C has a paralog, YGL082W, that arose from the whole genome duplication; ortholog of human MINDY2/FAM63B","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006112","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL191C"}


id: YPL192C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PRM3","product":"Protein required for nuclear envelope fusion during karyogamy; pheromone-regulated; peripheral protein of the nuclear membrane; interacts with Kar5p at the spindle pole body","secondary_identifier":"SGD:S000006113","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL192C"}


id: YPL193W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05679":null,"YPL193W":null},"has_protein_features":false,"name":"RSA1","ortholog_annotations":[{"gene_uniquename":"YPL193W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05679","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006114","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL193W"}


id: YPL194W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01605":null,"YPL194W":null},"has_protein_features":false,"name":"DDC1","ortholog_annotations":[{"gene_uniquename":"YPL194W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01605","reference_uniquename":"PMID:29761456"}],"product":"DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006115","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL194W"}


id: YPL195W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00108":null,"YPL195W":null},"has_protein_features":false,"name":"APL5","ortholog_annotations":[{"gene_uniquename":"YPL195W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00108","reference_uniquename":"PMID:29761456"}],"product":"Delta adaptin-like subunit of the clathrin associated protein complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; suppressor of loss of casein kinase 1 function; the clathrin associated protein complex is also known as AP-3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006116","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL195W"}


id: YPL196W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02470":null,"YPL196W":null},"has_protein_features":false,"name":"OXR1","ortholog_annotations":[{"gene_uniquename":"YPL196W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02470","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function required for oxidative damage resistance; required for normal levels of resistance to oxidative damage; null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006117","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL196W"}


id: YPL197C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the ribosomal gene RPL7B","secondary_identifier":"SGD:S000006118","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL197C"}


id: YPL198W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01551":null,"SJAG_03425":null,"YPL198W":null},"has_protein_features":false,"name":"RPL7B","ortholog_annotations":[{"gene_uniquename":"YPL198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01551","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03425","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L7B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006119","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL198W"}


id: YPL199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01979":null,"YPL199C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPL199C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01979","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in nonstop mRNA decay; predicted to be palmitoylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006120","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL199C"}


id: YPL200W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CSM4","product":"Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements; functions with meiosis-specific telomere-binding protein Ndj1p; CSM4 has a paralog, MPS2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006121","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL200W"}


