# genes

id: YMR315W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02154":null,"SJAG_02191":null,"YMR315W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YMR315W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02154","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR315W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02191","reference_uniquename":"PMID:29761456"}],"product":"Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004932","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR315W"}


id: YMR315W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028697","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR315W-A"}


id: YMR316C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; mRNA identified as translated by ribosome profiling data; overlaps the verified gene DIA1/YMR316W","secondary_identifier":"SGD:S000004933","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR316C-A"}


id: YMR316C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps 5' end of ORF YMR317W","secondary_identifier":"SGD:S000004934","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR316C-B"}


id: YMR316W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DIA1","product":"Protein of unknown function; involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern","secondary_identifier":"SGD:S000004935","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR316W"}


id: YMR317W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; has some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene","secondary_identifier":"SGD:S000004936","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR317W"}


id: YMR318C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02963":null,"YMR318C":null},"has_protein_features":false,"name":"ADH6","ortholog_annotations":[{"gene_uniquename":"YMR318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02963","reference_uniquename":"PMID:26896847"}],"product":"NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004937","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR318C"}


id: YMR319C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02968":null,"YMR319C":null},"has_protein_features":false,"name":"FET4","ortholog_annotations":[{"gene_uniquename":"YMR319C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02968","reference_uniquename":"PMID:29761456"}],"product":"Low-affinity Fe(II) transporter of the plasma membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004938","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR319C"}


id: YMR320W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YMR320W is not an essential gene","secondary_identifier":"SGD:S000004939","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR320W"}


id: YMR321C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04425":null,"YMR321C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YMR321C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04425","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; proposed to be a palmitoylated membrane protein; YMR321C has a paralog, SAM4, that arose from a single-locus duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004940","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR321C"}


id: YMR322C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02988":null,"SJAG_04674":null,"YMR322C":null},"has_protein_features":false,"name":"SNO4","ortholog_annotations":[{"gene_uniquename":"YMR322C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02988","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR322C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04674","reference_uniquename":"PMID:29761456"}],"product":"Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004941","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR322C"}


id: YMR323W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00461":null,"SJAG_02107":null,"SJAG_02369":null,"YMR323W":null},"has_protein_features":false,"name":"ERR3","ortholog_annotations":[{"gene_uniquename":"YMR323W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00461","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR323W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02107","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR323W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02369","reference_uniquename":"PMID:29761456"}],"product":"Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant in glucose","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004942","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR323W"}


id: YMR324C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcription is AZF1 dependent in glycerol-lactate medium and SLT2 dependent in response to the lipid hydroperoxides","secondary_identifier":"SGD:S000004943","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR324C"}


id: YMR325W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU19","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions","secondary_identifier":"SGD:S000004944","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR325W"}


id: YMR326C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13","secondary_identifier":"SGD:S000004945","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR326C"}


id: YNCA0001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HRA1","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCA0001W"}


id: YNCA0003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR18","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCA0003W"}


id: YNCB0003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR56","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCB0003W"}


id: YNCB0008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCB0008W"}


id: YNCB0009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR161","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCB0009C"}


id: YNCB0014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TBRT","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCB0014W"}


id: YNCC0003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR43","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCC0003C"}


id: YNCC0006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR33","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCC0006C"}


id: YNCC0011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR65","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCC0011W"}


id: YNCC0012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR189","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCC0012C"}


id: YNCD0002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR63","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCD0002C"}


id: YNCD0010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR47","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCD0010C"}


id: YNCD0030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR13","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCD0030W"}


id: YNCD0032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR84","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCD0032C"}


id: YNCE0001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR80","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCE0001C"}


id: YNCE0002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR67","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCE0002W"}


id: YNCE0003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR53","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCE0003W"}


id: YNCE0007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RPR1","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCE0007C"}


id: YNCE0017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SRG1","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCE0017W"}


id: YNCE0019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR4","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCE0019W"}


id: YNCE0020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR52","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCE0020C"}


id: YNCE0024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SCR1","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCE0024W"}


id: YNCF0001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RUF21","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCF0001C"}


id: YNCF0003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RUF20","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCF0003C"}


id: YNCF0010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RUF22","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCF0010C"}


id: YNCF0013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RUF23","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCF0013W"}


id: YNCG0001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RME3","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCG0001C"}


id: YNCG0006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RME2","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCG0006C"}


id: YNCG0010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR82","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCG0010W"}


id: YNCG0013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR10","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCG0013W"}


id: YNCG0014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR39","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCG0014C"}


id: YNCG0015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR39B","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCG0015C"}


id: YNCG0024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR46","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCG0024W"}


id: YNCG0026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR48","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCG0026W"}


id: YNCH0007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RUF5-1","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCH0007W"}


id: YNCH0008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RUF5-2","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCH0008W"}


id: YNCH0011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SUT169","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCH0011W"}


id: YNCH0012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR32","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCH0012W"}


id: YNCH0014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR71","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCH0014W"}


id: YNCI0001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR68","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCI0001W"}


id: YNCI0012
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ICR1","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCI0012"}


id: YNCI0013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PWR1","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCI0013W"}


id: YNCJ0003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR128","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCJ0003C"}


id: YNCJ0004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR190","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCJ0004C"}


id: YNCJ0007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR37","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCJ0007C"}


id: YNCJ0009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR60","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCJ0009C"}


id: YNCJ0028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IRT1","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCJ0028C"}


id: YNCJ0030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR3","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCJ0030W"}


id: YNCK0001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR64","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCK0001W"}


id: YNCK0009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR38","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCK0009W"}


id: YNCK0013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR69","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCK0013W"}


id: YNCK0015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR87","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCK0015C"}


id: YNCK0020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR42","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCK0020C"}


id: YNCL0003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR30","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCL0003W"}


id: YNCL0005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR79","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCL0005C"}


id: YNCL0041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR61","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCL0041C"}


id: YNCL0042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR55","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCL0042C"}


id: YNCL0043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR57","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCL0043C"}


id: YNCL0046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR44","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCL0046W"}


id: YNCL0048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR34","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCL0048W"}


id: YNCM0001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCM0001W"}


id: YNCM0002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR85","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCM0002C"}


id: YNCM0003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ZOD1","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCM0003W"}


id: YNCM0005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR54","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCM0005C"}


id: YNCM0011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR78","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCM0011W"}


id: YNCM0012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR77","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCM0012W"}


id: YNCM0013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR76","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCM0013W"}


id: YNCM0014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR75","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCM0014W"}


id: YNCM0015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR74","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCM0015W"}


id: YNCM0016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR73","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCM0016W"}


id: YNCM0017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR72","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCM0017W"}


id: YNCM0026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR24","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCM0026C"}


id: YNCM0030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR83","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCM0030W"}


id: YNCM0031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR11","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCM0031W"}


id: YNCM0032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RNA170","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCM0032C"}


id: YNCM0034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR86","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCM0034C"}


id: YNCN0001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR40","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCN0001W"}


id: YNCN0013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NME1","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCN0013W"}


id: YNCN0014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR66","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCN0014W"}


id: YNCN0018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR49","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCN0018W"}


id: YNCN0019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR191","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCN0019C"}


id: YNCO0003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR58","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCO0003C"}


id: YNCO0006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR81","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCO0006W"}


id: YNCO0007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR50","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCO0007W"}


id: YNCO0014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR9","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCO0014C"}


id: YNCO0015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR62","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCO0015C"}


id: YNCO0022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR36","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCO0022C"}


id: YNCO0024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR35","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCO0024C"}


id: YNCO0025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR17A","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCO0025W"}


id: YNCO0026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR8","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCO0026W"}


id: YNCO0027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR31","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCO0027C"}


id: YNCO0028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR5","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCO0028W"}


id: YNCP0002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCP0002W"}


id: YNCP0003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR59","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCP0003W"}


id: YNCP0005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR17B","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCP0005C"}


id: YNCP0013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR51","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCP0013C"}


id: YNCP0014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR70","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCP0014C"}


id: YNCP0015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR41","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCP0015C"}


id: YNCP0021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNR45","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCP0021W"}


id: YNCQ0027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RPM1","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNCQ0027W"}


id: YNL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04283":null,"YNL001W":null},"has_protein_features":false,"name":"DOM34","ortholog_annotations":[{"gene_uniquename":"YNL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04283","reference_uniquename":"PMID:29761456"}],"product":"Protein that facilitates ribosomal subunit dissociation; Dom34-Hbs1 complex and Rli1p have roles in dissociating inactive ribosomes to facilitate translation restart, particularly ribosomes stalled in 3' UTRs; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004946","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL001W"}


id: YNL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01606":null,"YNL002C":null},"has_protein_features":false,"name":"RLP7","ortholog_annotations":[{"gene_uniquename":"YNL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01606","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein similar to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs; binds junction of ITS2 and ITS2-proximal stem between the 3' end of 5.8S rRNA and the 5' end of 25S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004947","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL002C"}


id: YNL003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01589":null,"SJAG_01890":null,"YNL003C":null},"has_protein_features":false,"name":"PET8","ortholog_annotations":[{"gene_uniquename":"YNL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01589","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01890","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine transporter of the mitochondrial inner membrane; member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004948","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL003C"}


id: YNL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01529":null,"YNL004W":null},"has_protein_features":false,"name":"HRB1","ortholog_annotations":[{"gene_uniquename":"YNL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01529","reference_uniquename":"PMID:29761456"}],"product":"Poly(A+) RNA-binding protein; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004949","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL004W"}


id: YNL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03636":null,"YNL005C":null},"has_protein_features":false,"name":"MRP7","ortholog_annotations":[{"gene_uniquename":"YNL005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03636","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; involved together with Mrpl35p in assembly of cytochrome c oxidase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004950","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL005C"}


id: YNL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01320":null,"YNL006W":null},"has_protein_features":false,"name":"LST8","ortholog_annotations":[{"gene_uniquename":"YNL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01320","reference_uniquename":"PMID:29761456"}],"product":"Protein required for the transport of Gap1p; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004951","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL006W"}


id: YNL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03794":null,"YNL007C":null},"has_protein_features":false,"name":"SIS1","ortholog_annotations":[{"gene_uniquename":"YNL007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03794","reference_uniquename":"PMID:29761456"}],"product":"Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; shuttles between cytosol and nucleus; mediates delivery of misfolded proteins into the nucleus for degradation; involved in proteasomal degradation of misfolded cytosolic proteins; protein abundance increases in response to DNA replication stress; polyQ aggregates sequester Sis1p and interfere with clearance of misfolded proteins; similar to bacterial DnaJ proteins and mammalian DnaJB1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004952","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL007C"}


id: YNL008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ASI3","product":"Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and regulators of sterol biosynthesis for ubiquitin-mediated degradation; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids","secondary_identifier":"SGD:S000004953","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL008C"}


id: YNL009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04362":null,"YNL009W":null},"has_protein_features":false,"name":"IDP3","ortholog_annotations":[{"gene_uniquename":"YNL009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04362","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004954","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL009W"}


id: YNL010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04964":null,"YNL010W":null},"has_protein_features":false,"name":"PYP1","ortholog_annotations":[{"gene_uniquename":"YNL010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04964","reference_uniquename":"PMID:29761456"}],"product":"Sugar alcohol phosphatase; polyol phosphatase that hydrolyzes sorbitol-6-phosphate, ribitol-5-phosphate, and (D)-glycerol-3-phosphate, maintaining phosphoglucose isomerase (PGI) activity in the presence of PGI-inhibitory sugar alcohols; expression correlated with growth rate; GFP-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant displays increased glycogen accumulation; member of the haloacid dehalogenase (HAD) superfamily","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004955","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL010W"}


id: YNL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YNL011C is not an essential gene","secondary_identifier":"SGD:S000004956","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL011C"}


id: YNL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPO1","product":"Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B","secondary_identifier":"SGD:S000004957","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL012W"}


id: YNL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W","secondary_identifier":"SGD:S000004958","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL013C"}


id: YNL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02738":null,"YNL014W":null},"has_protein_features":false,"name":"HEF3","ortholog_annotations":[{"gene_uniquename":"YNL014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02738","reference_uniquename":"PMID:29761456"}],"product":"Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004959","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL014W"}


id: YNL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01072":null,"YNL015W":null},"has_protein_features":false,"name":"PBI2","ortholog_annotations":[{"gene_uniquename":"YNL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01072","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic inhibitor of vacuolar proteinase B (PRB1); required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004960","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL015W"}


id: YNL016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01440":null,"YNL016W":null},"has_protein_features":false,"name":"PUB1","ortholog_annotations":[{"gene_uniquename":"YNL016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01440","reference_uniquename":"PMID:26896847"}],"product":"Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; implicated in regulation of translation; carries Q/N-rich domain at C- terminus, identified as candidate prion; ribosome-bound Pub1p modulates stop codon decoding during translation termination","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004961","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL016W"}


id: YNL017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the tRNA ORF tI(AAU)N2","secondary_identifier":"SGD:S000004962","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL017C"}


id: YNL018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YNL018C has a paralog, YNL034W, that arose from a segmental duplication","secondary_identifier":"SGD:S000004963","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL018C"}


id: YNL019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; expression induced during heat stress; YNL019C has a paralog, YNL033W, that arose from a segmental duplication","secondary_identifier":"SGD:S000004964","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL019C"}


id: YNL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00649":null,"SJAG_04052":null,"SJAG_04465":null,"YNL020C":null},"has_protein_features":false,"name":"ARK1","ortholog_annotations":[{"gene_uniquename":"YNL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00649","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04052","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04465","reference_uniquename":"PMID:29761456"}],"product":"Ser/Thr protein kinase; phosphorylates Pan1p-Sla1p-End3p protein complex subunits, Pan1p and Sla1p; involved in regulation of the cortical actin cytoskeleton and endocytosis; functional overlap with PRK1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004965","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL020C"}


id: YNL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03844":null,"YNL021W":null},"has_protein_features":false,"name":"HDA1","ortholog_annotations":[{"gene_uniquename":"YNL021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03844","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of class II HDA1 histone deacetylase complex; role in azole resistance via Hsp90p, and in heat shock response; Hda1p interacts with Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation; the HDA1 histone deacetylase complex regulates aging through trehalose metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004966","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL021W"}


id: YNL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03877":null,"YNL022C":null},"has_protein_features":false,"name":"RCM1","ortholog_annotations":[{"gene_uniquename":"YNL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03877","reference_uniquename":"PMID:29761456"}],"product":"rRNA m5C methyltransferase; methylates cytosine at position 2278 of 25S rRNA while Nop2p methylates cytosine at position 2870; contains seven beta-strand methyltransferase motif; localized to the nucleolus; interacts with Trm112p; homolog of NSUN5A, a human gene which is deleted in Williams-Beuren Syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004967","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL022C"}


id: YNL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02752":null,"YNL023C":null},"has_protein_features":false,"name":"FAP1","ortholog_annotations":[{"gene_uniquename":"YNL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02752","reference_uniquename":"PMID:29761456"}],"product":"Protein that binds to Fpr1p; confers rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004968","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL023C"}


id: YNL024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"EFM6","product":"Putative S-adenosylmethionine-dependent lysine methyltransferase; responsible for modifying Lys-390 in translational elongation factor EF-1 alpha (eEF1A); has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000004969","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL024C"}


id: YNL024C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05736":null,"YNL024C-A":null},"has_protein_features":false,"name":"KSH1","ortholog_annotations":[{"gene_uniquename":"YNL024C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05736","reference_uniquename":"PMID:29761456"}],"product":"Essential protein suggested to function early in the secretory pathway; inviability is suppressed by overexpression of Golgi protein Tvp23p; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and cytosol respectively; ortholog of human Kish","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028698","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL024C-A"}


id: YNL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00613":null,"YNL025C":null},"has_protein_features":false,"name":"SSN8","ortholog_annotations":[{"gene_uniquename":"YNL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00613","reference_uniquename":"PMID:29761456"}],"product":"Cyclin-like component of RNA polymerase II holoenzyme; involved in phosphorylation of RNAPII C-terminal domain; forms kinase-cyclin pair in RNAPII holoenzyme with Ssn3p; needed for entry into and execution of meiotic program; involved in glucose repression, telomere maintenance; degraded in response to nitrogen starvation, and also to oxidative stress, but in different cellular compartments, and with different cellular outcomes; 35% identical to human cyclin C","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004970","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL025C"}


id: YNL026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01951":null,"YNL026W":null},"has_protein_features":false,"name":"SAM50","ortholog_annotations":[{"gene_uniquename":"YNL026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01951","reference_uniquename":"PMID:29761456"}],"product":"Component of the Sorting and Assembly Machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004971","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL026W"}


id: YNL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03879":null,"YNL027W":null},"has_protein_features":false,"name":"CRZ1","ortholog_annotations":[{"gene_uniquename":"YNL027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03879","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress; can be activated in stochastic pulses of nuclear localization in response to calcium","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004972","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL027W"}


id: YNL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004973","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL028W"}


id: YNL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02519":null,"SJAG_03082":null,"YNL029C":null},"has_protein_features":false,"name":"KTR5","ortholog_annotations":[{"gene_uniquename":"YNL029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02519","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03082","reference_uniquename":"PMID:29761456"}],"product":"Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR5 has a paralog, KTR7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004974","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL029C"}


id: YNL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00303":null,"SJAG_00336":null,"SJAG_03542":null,"YNL030W":null},"has_protein_features":false,"name":"HHF2","ortholog_annotations":[{"gene_uniquename":"YNL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00303","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00336","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03542","reference_uniquename":"PMID:29761456"}],"product":"Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004975","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL030W"}


id: YNL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00302":null,"SJAG_00335":null,"SJAG_03543":null,"YNL031C":null},"has_protein_features":false,"name":"HHT2","ortholog_annotations":[{"gene_uniquename":"YNL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00302","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00335","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03543","reference_uniquename":"PMID:29761456"}],"product":"Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004976","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL031C"}


id: YNL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01154":null,"YNL032W":null},"has_protein_features":false,"name":"SIW14","ortholog_annotations":[{"gene_uniquename":"YNL032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01154","reference_uniquename":"PMID:29761456"}],"product":"Inositol phosphatase involved in inositol pyrophosphate metabolism; hydrolyzes the beta-phosphate from the 5-diphosphate group of PP-InsPs including: 5PP-IP5 (IP7), 1,5PP-IP4 (IP8) and 5-PP-InsP4; functions as an anti-prion (anti-[PSI]) component; member of the atypical dual-specificity subgroup of the protein tyrosine-phosphatase (PTP) superfamily; localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004977","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL032W"}


id: YNL033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YNL033W has a paralog, YNL019C, that arose from a segmental duplication","secondary_identifier":"SGD:S000004978","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL033W"}


id: YNL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; not an essential gene; YNL034W has a paralog, YNL018C, that arose from a segmental duplication","secondary_identifier":"SGD:S000004979","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL034W"}


id: YNL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04234":null,"YNL035C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04234","reference_uniquename":"PMID:29761456"}],"product":"Nuclear protein of unknown function; relocalizes to the cytosol in response to hypoxia; contains WD-40 domains; not an essential gene; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004980","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL035C"}


id: YNL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06611":null,"YNL036W":null},"has_protein_features":false,"name":"NCE103","ortholog_annotations":[{"gene_uniquename":"YNL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06611","reference_uniquename":"PMID:29761456"}],"product":"Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004981","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL036W"}


id: YNL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IDH1","product":"Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle","secondary_identifier":"SGD:S000004982","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL037C"}


id: YNL038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02804":null,"YNL038W":null},"has_protein_features":false,"name":"GPI15","ortholog_annotations":[{"gene_uniquename":"YNL038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02804","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004983","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL038W"}


id: YNL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03007":null,"YNL039W":null},"has_protein_features":false,"name":"BDP1","ortholog_annotations":[{"gene_uniquename":"YNL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03007","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of RNA polymerase III transcription factor (TFIIIB); TFIIIB is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004984","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL039W"}


id: YNL040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; has strong similarity to alanyl-tRNA synthases from Eubacteria; null mutant displays decreased translation rate and increased readthrough of premature stop codons; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene","secondary_identifier":"SGD:S000004985","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL040W"}


id: YNL041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03158":null,"YNL041C":null},"has_protein_features":false,"name":"COG6","ortholog_annotations":[{"gene_uniquename":"YNL041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03158","reference_uniquename":"PMID:29761456"}],"product":"Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004986","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL041C"}


id: YNL042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BOP3","product":"Protein of unknown function; potential Cdc28p substrate; overproduction confers resistance to methylmercury","secondary_identifier":"SGD:S000004987","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL042W"}


id: YNL042W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028850","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL042W-B"}


id: YNL043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W","secondary_identifier":"SGD:S000004988","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL043C"}


id: YNL044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00767":null,"YNL044W":null},"has_protein_features":false,"name":"YIP3","ortholog_annotations":[{"gene_uniquename":"YNL044W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00767","reference_uniquename":"PMID:29761456"}],"product":"Protein localized to COPII vesicles; proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004989","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL044W"}


id: YNL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01088":null,"YNL045W":null},"has_protein_features":false,"name":"LAP2","ortholog_annotations":[{"gene_uniquename":"YNL045W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01088","reference_uniquename":"PMID:29761456"}],"product":"Leucyl aminopeptidase yscIV with epoxide hydrolase activity; metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; also known as leukotriene A4 hydrolase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004990","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL045W"}


id: YNL046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)","secondary_identifier":"SGD:S000004991","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL046W"}


id: YNL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02989":null,"YNL047C":null},"has_protein_features":false,"name":"SLM2","ortholog_annotations":[{"gene_uniquename":"YNL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02989","reference_uniquename":"PMID:29761456"}],"product":"Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; TORC2 complex substrate and effector; SLM2 has a paralog, SLM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004992","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL047C"}


id: YNL048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00747":null,"YNL048W":null},"has_protein_features":false,"name":"ALG11","ortholog_annotations":[{"gene_uniquename":"YNL048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00747","reference_uniquename":"PMID:29761456"}],"product":"Alpha-1,2-mannosyltransferase; catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004993","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL048W"}


id: YNL049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00072":null,"YNL049C":null},"has_protein_features":false,"name":"SFB2","ortholog_annotations":[{"gene_uniquename":"YNL049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00072","reference_uniquename":"PMID:29761456"}],"product":"Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SFB2 has a paralog, SEC24, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004994","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL049C"}


id: YNL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03020":null,"YNL050C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNL050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03020","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; YNL050c is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004995","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL050C"}


id: YNL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02211":null,"YNL051W":null},"has_protein_features":false,"name":"COG5","ortholog_annotations":[{"gene_uniquename":"YNL051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02211","reference_uniquename":"PMID:29761456"}],"product":"Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004996","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL051W"}


id: YNL052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01077":null,"YNL052W":null},"has_protein_features":false,"name":"COX5A","ortholog_annotations":[{"gene_uniquename":"YNL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01077","reference_uniquename":"PMID:29761456"}],"product":"Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004997","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL052W"}


id: YNL053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03263":null,"YNL053W":null},"has_protein_features":false,"name":"MSG5","ortholog_annotations":[{"gene_uniquename":"YNL053W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03263","reference_uniquename":"PMID:29761456"}],"product":"Dual-specificity protein phosphatase; maintains low levels of both basal and induced cell integrity pathway signaling by dephosphorylation of the Slt2p MAPK; reciprocally regulated by Slt2p through phosphorylation; minor role with Ptp2p in the adaptive response to pheromone through the dephosphorylation of the Fus3p MAPK with major contribution by Ptp3p; inhibits the nuclear accumulation of Fus3p; two isoforms exist as the result of alternative translation initiation starts","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004998","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL053W"}


id: YNL054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02665":null,"YNL054W":null},"has_protein_features":false,"name":"VAC7","ortholog_annotations":[{"gene_uniquename":"YNL054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02665","reference_uniquename":"PMID:29761456"}],"product":"Integral vacuolar membrane protein; involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004999","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL054W"}


id: YNL055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00048":null,"YNL055C":null},"has_protein_features":false,"name":"POR1","ortholog_annotations":[{"gene_uniquename":"YNL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00048","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; couples the glutathione pools of the intermembrane space (IMS) and the cytosol; interacts with Om45 and Om14 in the outer membrane; phosphorylated; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005000","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL055C"}


id: YNL056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OCA2","product":"Protein of unknown function; similar to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene","secondary_identifier":"SGD:S000005001","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL056W"}


id: YNL057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005002","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL057W"}


id: YNL058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to vacuole; not an essential gene; YNL058C has a paralog, PRM5, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005003","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL058C"}


id: YNL059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03839":null,"YNL059C":null},"has_protein_features":false,"name":"ARP5","ortholog_annotations":[{"gene_uniquename":"YNL059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03839","reference_uniquename":"PMID:29761456"}],"product":"Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005004","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL059C"}


id: YNL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02417":null,"YNL061W":null},"has_protein_features":false,"name":"NOP2","ortholog_annotations":[{"gene_uniquename":"YNL061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02417","reference_uniquename":"PMID:29761456"}],"product":"rRNA m5C methyltransferase; methylates cytosine at position 2870 of 25S rRNA; has an essential function independent of rRNA methylation; contains seven beta-strand methyltransferase motif; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles; rRNA methylation defect and lethality are functionally complemented by human NOP2, a gene upregulated in cancer","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005005","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL061W"}


id: YNL062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02637":null,"YNL062C":null},"has_protein_features":false,"name":"GCD10","ortholog_annotations":[{"gene_uniquename":"YNL062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02637","reference_uniquename":"PMID:29761456"}],"product":"Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005006","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL062C"}


id: YNL063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00286":null,"YNL063W":null},"has_protein_features":false,"name":"MTQ1","ortholog_annotations":[{"gene_uniquename":"YNL063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00286","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005007","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL063W"}


id: YNL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00436":null,"YNL064C":null},"has_protein_features":false,"name":"YDJ1","ortholog_annotations":[{"gene_uniquename":"YNL064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00436","reference_uniquename":"PMID:29761456"}],"product":"Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; acts as an adaptor that helps Rsp5p recognize cytosolic misfolded proteins for ubiquitination after heat shock; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family; chimeric protein in which human p58IPK J domain replaces yeast Ydj1p J domain can complement yeast ydj1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005008","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL064C"}


id: YNL065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AQR1","product":"Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000005009","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL065W"}


id: YNL066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02649":null,"SJAG_03295":null,"YNL066W":null},"has_protein_features":false,"name":"SUN4","ortholog_annotations":[{"gene_uniquename":"YNL066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02649","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03295","reference_uniquename":"PMID:29761456"}],"product":"Cell wall protein related to glucanases localized in birth scars; possibly involved in cell wall septation; member of the SUN family; SUN4 has a paralog, SIM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005010","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL066W"}


id: YNL067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00629":null,"SJAG_00748":null,"YNL067W":null},"has_protein_features":false,"name":"RPL9B","ortholog_annotations":[{"gene_uniquename":"YNL067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00629","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00748","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L9B; homologous to mammalian ribosomal protein L9 and bacterial L6; RPL9B has a paralog, RPL9A, that arose from a single-locus duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005011","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL067W"}


id: YNL067W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007623","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL067W-A"}


id: YNL067W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028810","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL067W-B"}


id: YNL068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04813":null,"YNL068C":null},"has_protein_features":false,"name":"FKH2","ortholog_annotations":[{"gene_uniquename":"YNL068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04813","reference_uniquename":"PMID:29761456"}],"product":"Forkhead family transcription factor; rate-limiting activator of replication origins; evolutionarily conserved regulator of lifespan; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; positively regulates transcriptional elongation; facilitates clustering, activation of early-firing replication origins; negative role in chromatin silencing at HML and HMR; major role in expression of G2/M phase genes; relocalizes to cytosol under hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005012","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL068C"}


id: YNL069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02207":null,"SJAG_04160":null,"YNL069C":null},"has_protein_features":false,"name":"RPL16B","ortholog_annotations":[{"gene_uniquename":"YNL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02207","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04160","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005013","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL069C"}


id: YNL070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03502":null,"YNL070W":null},"has_protein_features":false,"name":"TOM7","ortholog_annotations":[{"gene_uniquename":"YNL070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03502","reference_uniquename":"PMID:29761456"}],"product":"Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005014","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL070W"}


id: YNL071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02158":null,"YNL071W":null},"has_protein_features":false,"name":"LAT1","ortholog_annotations":[{"gene_uniquename":"YNL071W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02158","reference_uniquename":"PMID:29761456"}],"product":"Dihydrolipoamide acetyltransferase component (E2) of the PDC; the pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA; metabolic longevity factor required for calorie restriction-mediated life span extension","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005015","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL071W"}


id: YNL072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02039":null,"YNL072W":null},"has_protein_features":false,"name":"RNH201","ortholog_annotations":[{"gene_uniquename":"YNL072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02039","reference_uniquename":"PMID:29761456"}],"product":"Ribonuclease H2 catalytic subunit; removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; role in ribonucleotide excision repair; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005016","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL072W"}


id: YNL073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04409":null,"YNL073W":null},"has_protein_features":false,"name":"MSK1","ortholog_annotations":[{"gene_uniquename":"YNL073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04409","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial lysine-tRNA synthetase; required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005017","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL073W"}


id: YNL074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MLF3","product":"Serine-rich protein of unknown function; predicted to be palmitoylated; overproduction suppresses growth inhibition caused by exposure to immunosuppressant leflunomide; MLF3 has a paralog, VHS2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005018","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL074C"}


id: YNL075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03252":null,"YNL075W":null},"has_protein_features":false,"name":"IMP4","ortholog_annotations":[{"gene_uniquename":"YNL075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03252","reference_uniquename":"PMID:29761456"}],"product":"Component of the SSU processome; SSU processome is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005019","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL075W"}


id: YNL076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03319":null,"YNL076W":null},"has_protein_features":false,"name":"MKS1","ortholog_annotations":[{"gene_uniquename":"YNL076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03319","reference_uniquename":"PMID:29761456"}],"product":"Pleiotropic negative transcriptional regulator; involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005020","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL076W"}


id: YNL077W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"APJ1","product":"Hsp40 chaperone with a role in SUMO-mediated protein degradation; works in concert with Hsp70 and Hsp110 (Sse1p) to promote disaggregation of intranuclear protein inclusions; competes with Hsp104 in disaggregation, supporting turnover instead of refolding; member of DnaJ-like family, conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; forms nuclear foci upon DNA replication stress","secondary_identifier":"SGD:S000005021","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL077W"}


id: YNL078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NIS1","product":"Protein involved in axial bud site selection; prevents repolarization of cells at previous division sites; recruited with Nba1p to the cell cortex and to cytokinesis remnants (bud scars) by Aim44p and Nap1p where Nba1p prevent Rsr1p-mediated activation of Cdc24p, and therefore Cdc42p activation; acts with Nba1p to establish transient bud scar localization of Rga1p, a Cdc42p GAP; localizes to the nucleus and to cell division site during G2/M, and is then stably recruited to cytokinesis remnants","secondary_identifier":"SGD:S000005022","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL078W"}


id: YNL079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04887":null,"YNL079C":null},"has_protein_features":false,"name":"TPM1","ortholog_annotations":[{"gene_uniquename":"YNL079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04887","reference_uniquename":"PMID:29761456"}],"product":"Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005023","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL079C"}


id: YNL080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03330":null,"YNL080C":null},"has_protein_features":false,"name":"EOS1","ortholog_annotations":[{"gene_uniquename":"YNL080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03330","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005024","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL080C"}


id: YNL081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00782":null,"YNL081C":null},"has_protein_features":false,"name":"SWS2","ortholog_annotations":[{"gene_uniquename":"YNL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00782","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency; localizes to vacuole in response to H2O2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005025","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL081C"}


id: YNL082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02187":null,"YNL082W":null},"has_protein_features":false,"name":"PMS1","ortholog_annotations":[{"gene_uniquename":"YNL082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02187","reference_uniquename":"PMID:29761456"}],"product":"ATP-binding protein required for mismatch repair; required for both mitosis and meiosis; functions as a heterodimer with Mlh1p; binds double- and single-stranded DNA via its N-terminal domain; required for silencing at the silent mating-type loci and telomeres; similar to E. coli MutL","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005026","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL082W"}


id: YNL083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00612":null,"YNL083W":null},"has_protein_features":false,"name":"SAL1","ortholog_annotations":[{"gene_uniquename":"YNL083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00612","reference_uniquename":"PMID:29761456"}],"product":"ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005027","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL083W"}


id: YNL084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03465":null,"YNL084C":null},"has_protein_features":false,"name":"END3","ortholog_annotations":[{"gene_uniquename":"YNL084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03465","reference_uniquename":"PMID:29761456"}],"product":"EH domain-containing protein involved in endocytosis; actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005028","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL084C"}


id: YNL085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00670":null,"YNL085W":null},"has_protein_features":false,"name":"MKT1","ortholog_annotations":[{"gene_uniquename":"YNL085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00670","reference_uniquename":"PMID:29761456"}],"product":"Protein similar to nucleases that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress; localization to P-bodies under ethanol stress differs between strains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005029","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL085W"}


id: YNL086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNN1","product":"Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; green fluorescent protein (GFP)-fusion protein localizes to endosomes","secondary_identifier":"SGD:S000005030","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL086W"}


id: YNL087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01437":null,"SJAG_04413":null,"SJAG_04417":null,"YNL087W":null},"has_protein_features":false,"name":"TCB2","ortholog_annotations":[{"gene_uniquename":"YNL087W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01437","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL087W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04413","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL087W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04417","reference_uniquename":"PMID:29761456"}],"product":"ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to bud; TCB2 has a paralog, TCB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005031","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL087W"}


id: YNL088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03567":null,"YNL088W":null},"has_protein_features":false,"name":"TOP2","ortholog_annotations":[{"gene_uniquename":"YNL088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03567","reference_uniquename":"PMID:29761456"}],"product":"Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; human homolog TOP2A implicated in cancers, and can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005032","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL088W"}


id: YNL089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins","secondary_identifier":"SGD:S000005033","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL089C"}


id: YNL090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00424":null,"YNL090W":null},"has_protein_features":false,"name":"RHO2","ortholog_annotations":[{"gene_uniquename":"YNL090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00424","reference_uniquename":"PMID:29761456"}],"product":"Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity and in microtubule assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005034","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL090W"}


id: YNL091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00423":null,"YNL091W":null},"has_protein_features":false,"name":"NST1","ortholog_annotations":[{"gene_uniquename":"YNL091W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00423","reference_uniquename":"PMID:29761456"}],"product":"Translational inhibitor and suppressor of proteasome-assembly defects; P-body component that inhibits translation, rescues proteasome base assembly defects and aggregation of regulatory particle subunits during stress when overexpressed; proposed to function to bridge the HOG and pheromone pathways with the cell wall integrity pathway in response to heat stress; interacts physically and genetically with splicing factor MSL1; large, highly-charge protein containing many disordered regions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005035","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL091W"}


id: YNL092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03087":null,"YNL092W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNL092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03087","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine-dependent protein methyltransferase; capable of automethylation; member of the seven beta-strand family; YNL092W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005036","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL092W"}


id: YNL093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01379":null,"YNL093W":null},"has_protein_features":false,"name":"YPT53","ortholog_annotations":[{"gene_uniquename":"YNL093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01379","reference_uniquename":"PMID:29761456"}],"product":"Stress-induced Rab family GTPase; required for vacuolar protein sorting and endocytosis; involved in ionic stress tolerance; similar to Vps21p and Ypt52p; functional homolog of Vps21p; mammalian Rab5 homolog; YPT53 has a paralog, VPS21, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005037","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL093W"}


id: YNL094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00920":null,"YNL094W":null},"has_protein_features":false,"name":"APP1","ortholog_annotations":[{"gene_uniquename":"YNL094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00920","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005038","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL094W"}


id: YNL095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005039","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL095C"}


id: YNL096C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02046":null,"YNL096C":null},"has_protein_features":false,"name":"RPS7B","ortholog_annotations":[{"gene_uniquename":"YNL096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02046","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005040","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL096C"}


id: YNL097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03230":null,"SJAG_03628":null,"YNL097C":null},"has_protein_features":false,"name":"PHO23","ortholog_annotations":[{"gene_uniquename":"YNL097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03230","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03628","reference_uniquename":"PMID:29761456"}],"product":"Component of the Rpd3L histone deacetylase complex; involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus shares significant sequence identity with the human candidate tumor suppressor p33-ING1 and its isoform ING3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005041","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL097C"}


id: YNL097C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028699","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL097C-B"}


id: YNL097W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene PHO23/YNL097C","secondary_identifier":"SGD:S000028700","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL097W-A"}


id: YNL098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03453":null,"YNL098C":null},"has_protein_features":false,"name":"RAS2","ortholog_annotations":[{"gene_uniquename":"YNL098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03453","reference_uniquename":"PMID:29761456"}],"product":"GTP-binding protein; regulates nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; activated by increased levels of glycolysis intermediate fructose-1,6-bisphosphate; homolog of mammalian Ras proto-oncogenes; RAS2 has a paralog, RAS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005042","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL098C"}


id: YNL099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OCA1","product":"Putative protein tyrosine phosphatase; required for cell cycle arrest in response to oxidative damage of DNA","secondary_identifier":"SGD:S000005043","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL099C"}


id: YNL100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02501":null,"YNL100W":null},"has_protein_features":false,"name":"MIC27","ortholog_annotations":[{"gene_uniquename":"YNL100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02501","reference_uniquename":"PMID:29761456"}],"product":"Component of the MICOS complex; MICOS (formerly MINOS or MitOS), a mitochondrial inner membrane complex that extends into the intermembrane space with a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic10p and Mic12p whose assembly and stability requires cardiolipin; orthologous to human APOO and APOOL","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005044","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL100W"}


id: YNL101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03400":null,"YNL101W":null},"has_protein_features":false,"name":"AVT4","ortholog_annotations":[{"gene_uniquename":"YNL101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03400","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005045","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL101W"}


id: YNL102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05239":null,"YNL102W":null},"has_protein_features":false,"name":"POL1","ortholog_annotations":[{"gene_uniquename":"YNL102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05239","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of the DNA polymerase I alpha-primase complex; required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005046","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL102W"}


id: YNL103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04749":null,"YNL103W":null},"has_protein_features":false,"name":"MET4","ortholog_annotations":[{"gene_uniquename":"YNL103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04749","reference_uniquename":"PMID:29761456"}],"product":"Leucine-zipper transcriptional activator; responsible for regulation of sulfur amino acid pathway; requires different combinations of auxiliary factors Cbf1p, Met28p, Met31p and Met32p; feedforward loop exists in the regulation of genes controlled by Met4p and Met32p; can be ubiquitinated by ubiquitin ligase SCF-Met30p, is either degraded or maintained in an inactive state; regulates degradation of its own DNA-binding cofactors by targeting them to SCF-Met30p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005047","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL103W"}


id: YNL103W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MET4/YNL104C","secondary_identifier":"SGD:S000028701","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL103W-A"}


id: YNL104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02841":null,"YNL104C":null},"has_protein_features":false,"name":"LEU4","ortholog_annotations":[{"gene_uniquename":"YNL104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02841","reference_uniquename":"PMID:29761456"}],"product":"Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005048","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL104C"}


id: YNL105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RRT16","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription","secondary_identifier":"SGD:S000005049","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL105W"}


id: YNL106C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00063":null,"SJAG_03375":null,"YNL106C":null},"has_protein_features":false,"name":"INP52","ortholog_annotations":[{"gene_uniquename":"YNL106C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00063","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL106C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03375","reference_uniquename":"PMID:29761456"}],"product":"Polyphosphatidylinositol phosphatase; dephosphorylates a number of phosphatidylinositol phosphates (PtdInsPs, PIPs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain; INP52 has a paralog, INP53, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005050","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL106C"}


id: YNL107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04097":null,"YNL107W":null},"has_protein_features":false,"name":"YAF9","ortholog_annotations":[{"gene_uniquename":"YNL107W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04097","reference_uniquename":"PMID:29761456"}],"product":"Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes; may function to antagonize silencing near telomeres; interacts directly with Swc4p; has homology to human leukemogenic protein AF9; contains a YEATS domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005051","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL107W"}


id: YNL108C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein phosphatase; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005052","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL108C"}


id: YNL109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C","secondary_identifier":"SGD:S000005053","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL109W"}


id: YNL110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00949":null,"SJAG_02952":null,"YNL110C":null},"has_protein_features":false,"name":"NOP15","ortholog_annotations":[{"gene_uniquename":"YNL110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00949","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02952","reference_uniquename":"PMID:29761456"}],"product":"Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005054","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL110C"}


id: YNL111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03929":null,"SJAG_04217":null,"YNL111C":null},"has_protein_features":false,"name":"CYB5","ortholog_annotations":[{"gene_uniquename":"YNL111C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03929","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL111C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04217","reference_uniquename":"PMID:29761456"}],"product":"Cytochrome b5; involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005055","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL111C"}


id: YNL112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05276":null,"YNL112W":null},"has_protein_features":false,"name":"DBP2","ortholog_annotations":[{"gene_uniquename":"YNL112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05276","reference_uniquename":"PMID:29761456"}],"product":"ATP-dependent RNA helicase of the DEAD-box protein family; has strong preference for dsRNA; remodels RNA-protein complex (RNP) to facilitate efficient transcription termination ; required for assembly of Yra1p, Nab2p and Mex67p onto mRNA and formation of nuclear mRNP; involved in mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005056","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL112W"}


id: YNL113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00731":null,"YNL113W":null},"has_protein_features":false,"name":"RPC19","ortholog_annotations":[{"gene_uniquename":"YNL113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00731","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase subunit AC19; common to RNA polymerases I and III","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005057","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL113W"}


id: YNL114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit","secondary_identifier":"SGD:S000005058","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL114C"}


id: YNL115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01795":null,"YNL115C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNL115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01795","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005059","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL115C"}


id: YNL116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02169":null,"YNL116W":null},"has_protein_features":false,"name":"DMA2","ortholog_annotations":[{"gene_uniquename":"YNL116W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02169","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-protein ligase (E3); controls septin dynamics and spindle position checkpoint (SPOC) with ligase Dma1p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8, similar to human Chfr; contains FHA and RING finger domains; DMA2 has a paralog, DMA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005060","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL116W"}


id: YNL117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MLS1","product":"Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA","secondary_identifier":"SGD:S000005061","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL117W"}


id: YNL118C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05010":null,"YNL118C":null},"has_protein_features":false,"name":"DCP2","ortholog_annotations":[{"gene_uniquename":"YNL118C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05010","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex; removes 5' cap structure from mRNAs prior to their degradation; also enters nucleus and positively regulates transcription initiation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress; human homolog DCP2 complements yeast dcp2 thermosensitive mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005062","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL118C"}


id: YNL119W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01302":null,"YNL119W":null},"has_protein_features":false,"name":"NCS2","ortholog_annotations":[{"gene_uniquename":"YNL119W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01302","reference_uniquename":"PMID:29761456"}],"product":"Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs; required for the thiolation of uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005063","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL119W"}


id: YNL120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene","secondary_identifier":"SGD:S000005064","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL120C"}


id: YNL121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04996":null,"YNL121C":null},"has_protein_features":false,"name":"TOM70","ortholog_annotations":[{"gene_uniquename":"YNL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04996","reference_uniquename":"PMID:29761456"}],"product":"Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005065","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL121C"}


id: YNL122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_07009":null,"YNL122C":null},"has_protein_features":false,"name":"MRP35","ortholog_annotations":[{"gene_uniquename":"YNL122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07009","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; homologous to bacterial L35 and human MRPL35 ribosomal proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005066","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL122C"}


id: YNL123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00737":null,"SJAG_03258":null,"YNL123W":null},"has_protein_features":false,"name":"NMA111","ortholog_annotations":[{"gene_uniquename":"YNL123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00737","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03258","reference_uniquename":"PMID:29761456"}],"product":"Serine protease and general molecular chaperone; cleaves Roq1p, which modifies the substrate specificity of the Ubr1p Ub-ligase, promoting the stress-induced homeostatically-regulated protein degradation (SHRED) of misfolded and native ER-membrane and cytosolic proteins; chaperone activity involved in the heat stress response; promotes apoptosis through proteolysis of Bir1p; role in lipid homeostasis; mammalian Omi/HtrA2 serine protease family member","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005067","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL123W"}


id: YNL124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03125":null,"YNL124W":null},"has_protein_features":false,"name":"NAF1","ortholog_annotations":[{"gene_uniquename":"YNL124W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03125","reference_uniquename":"PMID:29761456"}],"product":"RNA-binding protein required for the assembly of box H/ACA snoRNPs; thus required for pre-rRNA processing; forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005068","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL124W"}


id: YNL125C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ESBP6","product":"Protein with similarity to monocarboxylate permeases; appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane","secondary_identifier":"SGD:S000005069","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL125C"}


id: YNL126W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02609":null,"YNL126W":null},"has_protein_features":false,"name":"SPC98","ortholog_annotations":[{"gene_uniquename":"YNL126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02609","reference_uniquename":"PMID:29761456"}],"product":"Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005070","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL126W"}


id: YNL127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03508":null,"YNL127W":null},"has_protein_features":false,"name":"FAR11","ortholog_annotations":[{"gene_uniquename":"YNL127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03508","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in recovery from cell cycle arrest; acts in response to pheromone; also involved in regulation of intra-S DNA damage checkpoint and autophagy; is essential for dephosphorylation of Atg13p; interacts with Far3p, Far7p, Far8p, Far9p, Far10p and with the phosphatases Pph21p, Pph22p and Pph3p; has similarity to the N- and C-termini of N. crassa HAM-2; similar to human Fam40A and Fam40B","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005071","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL127W"}


id: YNL128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03131":null,"YNL128W":null},"has_protein_features":false,"name":"TEP1","ortholog_annotations":[{"gene_uniquename":"YNL128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03131","reference_uniquename":"PMID:29761456"}],"product":"PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005072","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL128W"}


id: YNL129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04693":null,"YNL129W":null},"has_protein_features":false,"name":"NRK1","ortholog_annotations":[{"gene_uniquename":"YNL129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04693","reference_uniquename":"PMID:29761456"}],"product":"Nicotinamide riboside kinase; catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005073","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL129W"}


id: YNL130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04319":null,"YNL130C":null},"has_protein_features":false,"name":"CPT1","ortholog_annotations":[{"gene_uniquename":"YNL130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04319","reference_uniquename":"PMID:29761456"}],"product":"Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005074","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL130C"}


id: YNL130C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DGR1","product":"Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose","secondary_identifier":"SGD:S000028579","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL130C-A"}


id: YNL131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03415":null,"YNL131W":null},"has_protein_features":false,"name":"TOM22","ortholog_annotations":[{"gene_uniquename":"YNL131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03415","reference_uniquename":"PMID:29761456"}],"product":"Component of the TOM (Translocase of Outer Membrane) complex; responsible for initial import of mitochondrially directed proteins; mediates interaction between TOM and TIM complexes and acts as receptor for precursor proteins; implicated in mitochondrial accumulation of amyloid β (Aβ) peptides via direct interaction with Aβ peptide residues 25-42 followed by transfer to Tom40p and transport through the TOM channel","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005075","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL131W"}


id: YNL132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01877":null,"YNL132W":null},"has_protein_features":false,"name":"KRE33","ortholog_annotations":[{"gene_uniquename":"YNL132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01877","reference_uniquename":"PMID:29761456"}],"product":"Acetyltransferase required for biogenesis of small ribosomal subunit; responsible for incorporation of N4-acetylcytidine into mRNAs; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance; essential gene; NAT10, the human homolog, implicated in several types of cancer and premature aging","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005076","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL132W"}


id: YNL133C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FYV6","product":"Protein of unknown function; required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining","secondary_identifier":"SGD:S000005077","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL133C"}


id: YNL134C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"NADH-dependent aldehyde reductase; involved in detoxification of furfural; expression is up-regulated in the presence of furfural and 5-hydroxymethylfurfural, which are compounds generated during lignocellulosic biomass pre-treatment; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000005078","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL134C"}


id: YNL135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04155":null,"YNL135C":null},"has_protein_features":false,"name":"FPR1","ortholog_annotations":[{"gene_uniquename":"YNL135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04155","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-prolyl cis-trans isomerase (PPIase); binds to FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function; associates with promoters of ribosomal protein genes; acts as chaperone to prevent protein aggregation; N-terminally propionylated in vivo; mutation is functionally complemented by human FKBP1A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005079","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL135C"}


id: YNL136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04793":null,"YNL136W":null},"has_protein_features":false,"name":"EAF7","ortholog_annotations":[{"gene_uniquename":"YNL136W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04793","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the NuA4 histone acetyltransferase complex; NuA4 acetylates the N-terminal tails of histones H4 and H2A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005080","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL136W"}


id: YNL137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00889":null,"YNL137C":null},"has_protein_features":false,"name":"NAM9","ortholog_annotations":[{"gene_uniquename":"YNL137C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00889","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal component of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005081","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL137C"}


id: YNL138W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01754":null,"YNL138W":null},"has_protein_features":false,"name":"SRV2","ortholog_annotations":[{"gene_uniquename":"YNL138W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01754","reference_uniquename":"PMID:29761456"}],"product":"CAP (cyclase-associated protein); N-terminus binds adenylate cyclase and facilitates activation by RAS; N-terminus forms novel hexameric star-shaped shuriken structures that directly catalyze cofilin-mediated severing of actin filaments; C-terminus binds and recycles cofilin bound, ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis; N- and C-termini can function as physically separate proteins; mCAP1 is the mouse homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005082","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL138W"}


id: YNL138W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05208":null,"YNL138W-A":null},"has_protein_features":false,"name":"YSF3","ortholog_annotations":[{"gene_uniquename":"YNL138W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05208","reference_uniquename":"PMID:29761456"}],"product":"Component of the SF3b subcomplex of the U2 snRNP; essential protein required for splicing and for assembly of SF3b","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028509","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL138W-A"}


id: YNL139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00992":null,"YNL139C":null},"has_protein_features":false,"name":"THO2","ortholog_annotations":[{"gene_uniquename":"YNL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00992","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the THO complex; THO is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005083","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL139C"}


id: YNL140C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C","secondary_identifier":"SGD:S000005084","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL140C"}


id: YNL141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AAH1","product":"Adenine deaminase (adenine aminohydrolase); converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome","secondary_identifier":"SGD:S000005085","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL141W"}


id: YNL142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04136":null,"YNL142W":null},"has_protein_features":false,"name":"MEP2","ortholog_annotations":[{"gene_uniquename":"YNL142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04136","reference_uniquename":"PMID:29761456"}],"product":"Ammonium permease involved in regulation of pseudohyphal growth; belongs to Mep-Amt-Rh family of well-conserved ammonium (NH4+) transporters that includes human Rh factors; expression is under the nitrogen catabolite repression regulation; activity is controlled by phospho-silencing; phosphorylation of Mep2 mediated by Npr1; dephosphorylation involves Psr1p and Psr2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005086","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL142W"}


id: YNL143C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels","secondary_identifier":"SGD:S000005087","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL143C"}


id: YNL144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a PH domain and binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; YNL144C has a paralog, YHR131C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005088","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL144C"}


id: YNL144W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YNL144C","secondary_identifier":"SGD:S000028702","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL144W-A"}


id: YNL145W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MFA2","product":"Mating pheromone a-factor; made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1","secondary_identifier":"SGD:S000005089","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL145W"}


id: YNL146C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028851","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL146C-A"}


id: YNL146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene","secondary_identifier":"SGD:S000005090","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL146W"}


id: YNL147W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05240":null,"YNL147W":null},"has_protein_features":false,"name":"LSM7","ortholog_annotations":[{"gene_uniquename":"YNL147W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05240","reference_uniquename":"PMID:29761456"}],"product":"Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005091","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL147W"}


id: YNL148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02040":null,"YNL148C":null},"has_protein_features":false,"name":"ALF1","ortholog_annotations":[{"gene_uniquename":"YNL148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02040","reference_uniquename":"PMID:29761456"}],"product":"Alpha-tubulin folding protein; similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005092","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL148C"}


id: YNL149C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00919":null,"YNL149C":null},"has_protein_features":false,"name":"PGA2","ortholog_annotations":[{"gene_uniquename":"YNL149C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00919","reference_uniquename":"PMID:29761456"}],"product":"Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005093","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL149C"}


id: YNL150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking","secondary_identifier":"SGD:S000005094","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL150W"}


id: YNL151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04161":null,"YNL151C":null},"has_protein_features":false,"name":"RPC31","ortholog_annotations":[{"gene_uniquename":"YNL151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04161","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase III subunit C31","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005095","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL151C"}


id: YNL152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00268":null,"YNL152W":null},"has_protein_features":false,"name":"INN1","ortholog_annotations":[{"gene_uniquename":"YNL152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00268","reference_uniquename":"PMID:29761456"}],"product":"Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005096","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL152W"}


id: YNL153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00524":null,"YNL153C":null},"has_protein_features":false,"name":"GIM3","ortholog_annotations":[{"gene_uniquename":"YNL153C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00524","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005097","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL153C"}


id: YNL154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00402":null,"SJAG_01373":null,"SJAG_03987":null,"YNL154C":null},"has_protein_features":false,"name":"YCK2","ortholog_annotations":[{"gene_uniquename":"YNL154C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00402","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL154C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01373","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL154C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03987","reference_uniquename":"PMID:29761456"}],"product":"Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; involved in the phosphorylation and regulation of glucose sensor Rgt2p; YCK2 has a paralog, YCK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005098","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL154C"}


id: YNL155W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CUZ1","product":"Protein with a role in the ubiquitin-proteasome pathway; interacts with ubiquitinated protein, Cdc48p and the proteasomal regulatory particle; may protect cells from trivalent metalloid induced proteotoxicity; contains a PACE promoter element and is co-regulated with proteasome subunit genes; AN1-type zinc finger protein, with DHHC and ubiquitin-like domains (UBL); ortholog of ZFAND1, a human gene linked to cancer; protein abundance increases under DNA replication stress","secondary_identifier":"SGD:S000005099","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL155W"}


id: YNL156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NSG2","product":"Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; NSG2 has a paralog, NSG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005100","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL156C"}


id: YNL157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03309":null,"YNL157W":null},"has_protein_features":false,"name":"IGO1","ortholog_annotations":[{"gene_uniquename":"YNL157W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03309","reference_uniquename":"PMID:29761456"}],"product":"Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; IGO1 has a paralog, IGO2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005101","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL157W"}


id: YNL158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06425":null,"YNL158W":null},"has_protein_features":false,"name":"PGA1","ortholog_annotations":[{"gene_uniquename":"YNL158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06425","reference_uniquename":"PMID:29761456"}],"product":"Essential component of GPI-mannosyltransferase II; complex is responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interactions with secretory pathway genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005102","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL158W"}


id: YNL159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ASI2","product":"Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; the Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and inner for ubiquitin-mediated degradation; acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids","secondary_identifier":"SGD:S000005103","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL159C"}


id: YNL160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YGP1","product":"Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; protein demonstrates amyloid properties in vivo; YGP1 has a paralog, SPS100, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005104","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL160W"}


id: YNL161W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00661":null,"YNL161W":null},"has_protein_features":false,"name":"CBK1","ortholog_annotations":[{"gene_uniquename":"YNL161W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00661","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005105","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL161W"}


id: YNL162W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04626":null,"YNL162W":null},"has_protein_features":false,"name":"RPL42A","ortholog_annotations":[{"gene_uniquename":"YNL162W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04626","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L42A; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42A has a paralog, RPL42B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005106","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL162W"}


id: YNL162W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by homology","secondary_identifier":"SGD:S000007624","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL162W-A"}


id: YNL163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02171":null,"YNL163C":null},"has_protein_features":false,"name":"RIA1","ortholog_annotations":[{"gene_uniquename":"YNL163C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02171","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, a guanine nucleotide exchange factor (GEF), promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005107","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL163C"}


id: YNL164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IBD2","product":"Component of the BUB2-dependent spindle checkpoint pathway; interacts with Bfa1p and functions upstream of Bub2p and Bfa1p","secondary_identifier":"SGD:S000005108","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL164C"}


id: YNL165W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YNL165W is not an essential gene","secondary_identifier":"SGD:S000005109","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL165W"}


id: YNL166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BNI5","product":"Linker protein responsible for recruitment of myosin to the bud neck; interacts with the C-terminal extensions of septins Cdc11p and Shs1p and binds Myo1p to promote cytokinesis","secondary_identifier":"SGD:S000005110","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL166C"}


id: YNL167C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00266":null,"SJAG_00979":null,"YNL167C":null},"has_protein_features":false,"name":"SKO1","ortholog_annotations":[{"gene_uniquename":"YNL167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00266","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YNL167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00979","reference_uniquename":"PMID:26896847"}],"product":"Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000005111","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL167C"}


id: YNL168C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00493":null,"YNL168C":null},"has_protein_features":false,"name":"FMP41","ortholog_annotations":[{"gene_uniquename":"YNL168C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00493","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005112","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL168C"}


id: YNL169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02980":null,"SJAG_03524":null,"YNL169C":null},"has_protein_features":false,"name":"PSD1","ortholog_annotations":[{"gene_uniquename":"YNL169C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02980","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL169C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03524","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylserine decarboxylase of the mitochondrial inner membrane; converts phosphatidylserine to phosphatidylethanolamine; regulates mitochondrial fusion and morphology; partly exposed to the mitochondrial intermembrane space; ER-localized fraction is involved in formation of lipid droplets; autocatalytically processed","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005113","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL169C"}


id: YNL170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005114","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL170W"}


id: YNL171C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005115","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL171C"}


id: YNL172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05329":null,"YNL172W":null},"has_protein_features":false,"name":"APC1","ortholog_annotations":[{"gene_uniquename":"YNL172W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05329","reference_uniquename":"PMID:29761456"}],"product":"Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005116","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL172W"}


id: YNL173C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MDG1","product":"Plasma membrane protein; involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations; MDG1 has a paralog, CRP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005117","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL173C"}


id: YNL174W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NOP13/YNL175C","secondary_identifier":"SGD:S000005118","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL174W"}


id: YNL175C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01650":null,"YNL175C":null},"has_protein_features":false,"name":"NOP13","ortholog_annotations":[{"gene_uniquename":"YNL175C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01650","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005119","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL175C"}


id: YNL176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TDA7","product":"Cell cycle-regulated gene of unknown function; promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele; TDA7 has a paralog, YDL211C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005120","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL176C"}


id: YNL177C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03192":null,"YNL177C":null},"has_protein_features":false,"name":"MRPL22","ortholog_annotations":[{"gene_uniquename":"YNL177C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03192","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005121","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL177C"}


id: YNL178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04814":null,"YNL178W":null},"has_protein_features":false,"name":"RPS3","ortholog_annotations":[{"gene_uniquename":"YNL178W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04814","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; nascent Rps3p is bound by specific chaperone Yar1p during translation; homologous to mammalian ribosomal protein S3 and bacterial S3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005122","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL178W"}


id: YNL179C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance","secondary_identifier":"SGD:S000005123","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL179C"}


id: YNL180C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RHO5","product":"Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; regulated by phosphorylation and ubiquitination; likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity; necessary for oxidant and ramped heat stress-induced cell death; ortholog of mammalian RAC1","secondary_identifier":"SGD:S000005124","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL180C"}


id: YNL181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03251":null,"YNL181W":null},"has_protein_features":false,"name":"PBR1","ortholog_annotations":[{"gene_uniquename":"YNL181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03251","reference_uniquename":"PMID:29761456"}],"product":"Putative oxidoreductase; required for cell viability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005125","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL181W"}


id: YNL182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04062":null,"YNL182C":null},"has_protein_features":false,"name":"IPI3","ortholog_annotations":[{"gene_uniquename":"YNL182C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04062","reference_uniquename":"PMID:29761456"}],"product":"Component of the Rix1 complex and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene; other members include Rix1p, Ipi1p, and Ipi3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005126","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL182C"}


id: YNL183C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00963":null,"SJAG_04268":null,"YNL183C":null},"has_protein_features":false,"name":"NPR1","ortholog_annotations":[{"gene_uniquename":"YNL183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00963","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04268","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase; stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis by phosphorylating Ldb19p; positively regulates activity of the three Mep ammonium transport proteins; mediates inhibitory phosphorylation of Mep2p and Par32p; TOR complex negatively regulates Npr1p activity; NPR1 has a paralog, PRR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005127","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL183C"}


id: YNL184C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels","secondary_identifier":"SGD:S000005128","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL184C"}


id: YNL185C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03297":null,"YNL185C":null},"has_protein_features":false,"name":"MRPL19","ortholog_annotations":[{"gene_uniquename":"YNL185C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03297","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005129","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL185C"}


id: YNL186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00764":null,"YNL186W":null},"has_protein_features":false,"name":"UBP10","ortholog_annotations":[{"gene_uniquename":"YNL186W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00764","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-specific protease, deubiquitinates Ub-protein moieties; interacts with proteins that function in rRNA production and ribosome biogenesis via its intrinsically disordered regions; stabilizes Rpa190p by deubiquitination; controls PCNA deubiquitylation; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p, possibly other transporters; localized to the nucleolus; null mutant phenotypes are functionally complemented by human USP36","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005130","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL186W"}


id: YNL187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SWT21","product":"Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats","secondary_identifier":"SGD:S000005131","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL187W"}


id: YNL188W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"KAR1","product":"Protein involved in karyogamy and spindle pole body duplication; involved in karyogamy during mating; involved in centrosome separation and duplication during mitosis; localizes to the half-bridge of the spindle pole body; interacts with Spc72p during karyogamy; also interacts with Cdc31p; essential gene","secondary_identifier":"SGD:S000005132","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL188W"}


id: YNL189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00840":null,"SJAG_04411":null,"YNL189W":null},"has_protein_features":false,"name":"SRP1","ortholog_annotations":[{"gene_uniquename":"YNL189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00840","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04411","reference_uniquename":"PMID:29761456"}],"product":"Karyopherin alpha homolog; forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; involved in cotranslational protein degradation; binds ribosome-bound nascent polypeptides; Srp1p and Sts1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005133","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL189W"}


id: YNL190W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Hydrophilin essential in desiccation-rehydration process; cell wall protein; contains a putative GPI-attachment site","secondary_identifier":"SGD:S000005134","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL190W"}


id: YNL191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DUG3","product":"Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)","secondary_identifier":"SGD:S000005135","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL191W"}


id: YNL192W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00442":null,"SJAG_04868":null,"YNL192W":null},"has_protein_features":false,"name":"CHS1","ortholog_annotations":[{"gene_uniquename":"YNL192W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00442","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL192W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04868","reference_uniquename":"PMID:29761456"}],"product":"Chitin synthase I; requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005136","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL192W"}


id: YNL193W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01666":null,"YNL193W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNL193W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01666","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005137","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL193W"}


id: YNL194C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Integral membrane protein; required for sporulation and plasma membrane sphingolipid content; similar to SUR7; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate; YNL194C has a paralog, FMP45, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005138","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL194C"}


id: YNL195C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL195C has a paralog, HBT1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005139","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL195C"}


id: YNL196C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SLZ1","product":"Sporulation-specific protein with a leucine zipper motif; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation","secondary_identifier":"SGD:S000005140","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL196C"}


id: YNL197C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01843":null,"SJAG_02554":null,"YNL197C":null},"has_protein_features":false,"name":"WHI3","ortholog_annotations":[{"gene_uniquename":"YNL197C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01843","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL197C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02554","reference_uniquename":"PMID:29761456"}],"product":"RNA binding protein that modulates mRNA stability; regulates genes involved in cell cycle, sister chromatid cohesion, and stress response; modulates stability and translational efficiency of CLN3 mRNA; colocalizes with P-bodies/stress granules where it may sequester specific mRNAs; regulates cell fate and critical cell size required for passage through Start; regulates ploidy; forms aggregates in older cells, leading to sterility","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005141","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL197C"}


id: YNL198C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005142","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL198C"}


id: YNL199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GCR2","product":"Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p","secondary_identifier":"SGD:S000005143","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL199C"}


id: YNL200C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02462":null,"YNL200C":null},"has_protein_features":false,"name":"NNR1","ortholog_annotations":[{"gene_uniquename":"YNL200C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02462","reference_uniquename":"PMID:29761456"}],"product":"NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005144","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL200C"}


id: YNL201C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00369":null,"YNL201C":null},"has_protein_features":false,"name":"PSY2","ortholog_annotations":[{"gene_uniquename":"YNL201C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00369","reference_uniquename":"PMID:29761456"}],"product":"Subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form the active complex, Psy4p may provide additional substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005145","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL201C"}


id: YNL202W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPS19","product":"Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate","secondary_identifier":"SGD:S000005146","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL202W"}


id: YNL203C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005147","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL203C"}


id: YNL204C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03268":null,"YNL204C":null},"has_protein_features":false,"name":"SPS18","ortholog_annotations":[{"gene_uniquename":"YNL204C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03268","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation; SPS18 has a paralog, GCS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005148","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL204C"}


id: YNL205C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005149","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL205C"}


id: YNL206C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RTT106","product":"Histone chaperone; involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition; interacts physically and functionally with Chromatin Assembly Factor-1 (CAF-1)","secondary_identifier":"SGD:S000005150","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL206C"}


id: YNL207W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01618":null,"YNL207W":null},"has_protein_features":false,"name":"RIO2","ortholog_annotations":[{"gene_uniquename":"YNL207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01618","reference_uniquename":"PMID:29761456"}],"product":"Essential serine kinase involved in the processing of 20S pre-rRNA; involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005151","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL207W"}


id: YNL208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi","secondary_identifier":"SGD:S000005152","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL208W"}


id: YNL209W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01874":null,"SJAG_03237":null,"YNL209W":null},"has_protein_features":false,"name":"SSB2","ortholog_annotations":[{"gene_uniquename":"YNL209W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01874","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YNL209W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03237","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005153","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL209W"}


id: YNL210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MER1","product":"mRNA-binding protein required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination; Mer1p regulon embraces four essential meiotic pre-mRNAs: REC107, HFM1, AMA1 and SPO22","secondary_identifier":"SGD:S000005154","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL210W"}


id: YNL211C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MRX7","product":"Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene","secondary_identifier":"SGD:S000005155","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL211C"}


id: YNL212W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02337":null,"YNL212W":null},"has_protein_features":false,"name":"VID27","ortholog_annotations":[{"gene_uniquename":"YNL212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02337","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth; contains two PH-like domains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005156","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL212W"}


id: YNL213C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RRG9","product":"Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000005157","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL213C"}


id: YNL214W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEX17","product":"Membrane peroxin of the peroxisomal importomer complex; complex facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis","secondary_identifier":"SGD:S000005158","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL214W"}


id: YNL215W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04989":null,"YNL215W":null},"has_protein_features":false,"name":"IES2","ortholog_annotations":[{"gene_uniquename":"YNL215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04989","reference_uniquename":"PMID:29761456"}],"product":"Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005159","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL215W"}


id: YNL216W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03092":null,"YNL216W":null},"has_protein_features":false,"name":"RAP1","ortholog_annotations":[{"gene_uniquename":"YNL216W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03092","reference_uniquename":"PMID:29761456"}],"product":"Essential DNA-binding transcription regulator that binds many loci; involved in transcription activation, repression, chromatin silencing, telomere length maintenance; represses divergent noncoding transcription at highly expressed genes, prevents transcription initiation at cryptic promoters near its binding sites; relocalizes to cytosol under hypoxia; recruits Sir complex to telomeric DNA; present in quiescent cell telomere hyperclusters","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005160","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL216W"}


id: YNL217W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00132":null,"YNL217W":null},"has_protein_features":false,"name":"PPN2","ortholog_annotations":[{"gene_uniquename":"YNL217W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00132","reference_uniquename":"PMID:29761456"}],"product":"Zn2+-dependent endopolyphosphatase; required with PPN1 to mobilize polyphosphate stores in response to phosphate starvation; member of the PPP-superfamily of metalloproteases; localizes to the vacuolar lumen via the MVB pathway; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005161","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL217W"}


id: YNL218W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02199":null,"YNL218W":null},"has_protein_features":false,"name":"MGS1","ortholog_annotations":[{"gene_uniquename":"YNL218W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02199","reference_uniquename":"PMID:29761456"}],"product":"Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005162","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL218W"}


id: YNL219C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00334":null,"YNL219C":null},"has_protein_features":false,"name":"ALG9","ortholog_annotations":[{"gene_uniquename":"YNL219C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00334","reference_uniquename":"PMID:29761456"}],"product":"Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of both the seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; human homolog ALG9 can complement yeast null mutant; mutation of human homolog causes type 1 congenital disorders of glycosylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005163","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL219C"}


id: YNL220W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00044":null,"YNL220W":null},"has_protein_features":false,"name":"ADE12","ortholog_annotations":[{"gene_uniquename":"YNL220W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00044","reference_uniquename":"PMID:29761456"}],"product":"Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005164","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL220W"}


id: YNL221C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04582":null,"YNL221C":null},"has_protein_features":false,"name":"POP1","ortholog_annotations":[{"gene_uniquename":"YNL221C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04582","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNase MRP, nuclear RNase P and telomerase complexes; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA; binds to the RPR1 RNA subunit in RNase P","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005165","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL221C"}


id: YNL222W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03624":null,"YNL222W":null},"has_protein_features":false,"name":"SSU72","ortholog_annotations":[{"gene_uniquename":"YNL222W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03624","reference_uniquename":"PMID:29761456"}],"product":"Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005166","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL222W"}


id: YNL223W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01283":null,"YNL223W":null},"has_protein_features":false,"name":"ATG4","ortholog_annotations":[{"gene_uniquename":"YNL223W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01283","reference_uniquename":"PMID:29761456"}],"product":"Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005167","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL223W"}


id: YNL224C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02256":null,"YNL224C":null},"has_protein_features":false,"name":"SQS1","ortholog_annotations":[{"gene_uniquename":"YNL224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02256","reference_uniquename":"PMID:29761456"}],"product":"Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005168","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL224C"}


id: YNL225C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01464":null,"YNL225C":null},"has_protein_features":false,"name":"CNM67","ortholog_annotations":[{"gene_uniquename":"YNL225C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01464","reference_uniquename":"PMID:29761456"}],"product":"Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005169","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL225C"}


id: YNL226W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C","secondary_identifier":"SGD:S000005170","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL226W"}


id: YNL227C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04991":null,"YNL227C":null},"has_protein_features":false,"name":"JJJ1","ortholog_annotations":[{"gene_uniquename":"YNL227C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04991","reference_uniquename":"PMID:29761456"}],"product":"Co-chaperone that stimulates the ATPase activity of Ssa1p; required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005171","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL227C"}


id: YNL228W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1","secondary_identifier":"SGD:S000005172","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL228W"}


id: YNL229C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00179":null,"SJAG_00238":null,"YNL229C":null},"has_protein_features":false,"name":"URE2","ortholog_annotations":[{"gene_uniquename":"YNL229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00179","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00238","reference_uniquename":"PMID:26896847"}],"product":"Nitrogen catabolite repression transcriptional regulator; inhibits GLN3 transcription in good nitrogen source; role in sequestering Gln3p and Gat1p to the cytoplasm; has glutathione peroxidase activity and can mutate to acquire GST activity; self-assembly under limited nitrogen conditions creates [URE3] prion and releases catabolite repression","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005173","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL229C"}


id: YNL230C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00540":null,"YNL230C":null},"has_protein_features":false,"name":"ELA1","ortholog_annotations":[{"gene_uniquename":"YNL230C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00540","reference_uniquename":"PMID:29761456"}],"product":"Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005174","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL230C"}


id: YNL231C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03721":null,"YNL231C":null},"has_protein_features":false,"name":"PDR16","ortholog_annotations":[{"gene_uniquename":"YNL231C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03721","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005175","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL231C"}


id: YNL232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01818":null,"YNL232W":null},"has_protein_features":false,"name":"CSL4","ortholog_annotations":[{"gene_uniquename":"YNL232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01818","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; human homolog EXOSC1 partially complements yeast csl4 null mutant, and can complement inviability of strain in which expression of CSL4 is repressed","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005176","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL232W"}


id: YNL233W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BNI4","product":"Targeting subunit for Glc7p protein phosphatase; localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p; phosphorylation by Slt2p and Kss1p involved in regulating Bni4p in septum assembly","secondary_identifier":"SGD:S000005177","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL233W"}


id: YNL234W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1","secondary_identifier":"SGD:S000005178","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL234W"}


id: YNL235C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex","secondary_identifier":"SGD:S000005179","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL235C"}


id: YNL236W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SIN4","product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both positive and negative transcriptional regulation; dispensible for basal transcription","secondary_identifier":"SGD:S000005180","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL236W"}


id: YNL237W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YTP1","product":"Probable type-III integral membrane protein of unknown function; has regions of similarity to mitochondrial electron transport proteins","secondary_identifier":"SGD:S000005181","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL237W"}


id: YNL238W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04398":null,"YNL238W":null},"has_protein_features":false,"name":"KEX2","ortholog_annotations":[{"gene_uniquename":"YNL238W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04398","reference_uniquename":"PMID:29761456"}],"product":"Kexin, a subtilisin-like protease (proprotein convertase); a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005182","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL238W"}


id: YNL239W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LAP3","product":"Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; cytosolic protein, selectively transported to vacuole during nitrogen starvation; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH","secondary_identifier":"SGD:S000005183","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL239W"}


id: YNL240C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02497":null,"YNL240C":null},"has_protein_features":false,"name":"NAR1","ortholog_annotations":[{"gene_uniquename":"YNL240C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02497","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery; required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; deficiency results in shortened lifespan and sensitivity to paraquat; homologous to human Narf","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005184","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL240C"}


id: YNL241C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02148":null,"SJAG_02297":null,"SJAG_02696":null,"YNL241C":null},"has_protein_features":false,"name":"ZWF1","ortholog_annotations":[{"gene_uniquename":"YNL241C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02148","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL241C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02297","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL241C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02696","reference_uniquename":"PMID:29761456"}],"product":"Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidative stress; protein abundance increases in response to DNA replication stress; homolog of human G6PD which is deficient in patients with hemolytic anemia; human G6PD can complement yeast zwf1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005185","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL241C"}


id: YNL242W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03851":null,"YNL242W":null},"has_protein_features":false,"name":"ATG2","ortholog_annotations":[{"gene_uniquename":"YNL242W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03851","reference_uniquename":"PMID:29761456"}],"product":"Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; contains an APT1 domain that binds phosphatidylinositol-3-phosphate; essential for cell cycle progression from G2/M to G1 under nitrogen starvation; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005186","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL242W"}


id: YNL243W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00152":null,"YNL243W":null},"has_protein_features":false,"name":"SLA2","ortholog_annotations":[{"gene_uniquename":"YNL243W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00152","reference_uniquename":"PMID:29761456"}],"product":"Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005187","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL243W"}


id: YNL244C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01117":null,"YNL244C":null},"has_protein_features":false,"name":"SUI1","ortholog_annotations":[{"gene_uniquename":"YNL244C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01117","reference_uniquename":"PMID:29761456"}],"product":"Translation initiation factor eIF1; component of complex involved in recognition of initiator codon; modulates translation accuracy at initiation phase by discriminating against suboptimal initiation sites to prevent excessive uORF translation genome-wide","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005188","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL244C"}


id: YNL245C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03993":null,"YNL245C":null},"has_protein_features":false,"name":"CWC25","ortholog_annotations":[{"gene_uniquename":"YNL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03993","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005189","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL245C"}


id: YNL246W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00170":null,"YNL246W":null},"has_protein_features":false,"name":"VPS75","ortholog_annotations":[{"gene_uniquename":"YNL246W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00170","reference_uniquename":"PMID:29761456"}],"product":"NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005190","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL246W"}


id: YNL247W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00420":null,"YNL247W":null},"has_protein_features":false,"name":"CRS1","ortholog_annotations":[{"gene_uniquename":"YNL247W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00420","reference_uniquename":"PMID:29761456"}],"product":"Cysteinyl-tRNA synthetase; CRS1 has two in-frame start codons resulting in a shorter isoform that is retained in the cytosol and a longer form that is mitochondrial; may interact with ribosomes, based on co-purification experiments; human gene CARS allows growth of the yeast haploid null mutant after sporulation of a heterozygous diploid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005191","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL247W"}


id: YNL248C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03956":null,"YNL248C":null},"has_protein_features":false,"name":"RPA49","ortholog_annotations":[{"gene_uniquename":"YNL248C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03956","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase I subunit A49; essential for nucleolar assembly and for high polymerase loading rate; required for nucleolar localization of Rpa34p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005192","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL248C"}


id: YNL249C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MPA43","product":"Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000005193","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL249C"}


id: YNL250W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01677":null,"YNL250W":null},"has_protein_features":false,"name":"RAD50","ortholog_annotations":[{"gene_uniquename":"YNL250W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01677","reference_uniquename":"PMID:29761456"}],"product":"Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005194","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL250W"}


id: YNL251C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04942":null,"YNL251C":null},"has_protein_features":false,"name":"NRD1","ortholog_annotations":[{"gene_uniquename":"YNL251C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04942","reference_uniquename":"PMID:29761456"}],"product":"RNA-binding subunit of Nrd1 complex; complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with CTD of RNA pol II large subunit Rpo21p at phosphorylated Ser5 to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites; role in regulation of mitochondrial abundance and cell size","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005195","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL251C"}


id: YNL252C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00086":null,"YNL252C":null},"has_protein_features":false,"name":"MRPL17","ortholog_annotations":[{"gene_uniquename":"YNL252C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00086","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005196","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL252C"}


id: YNL253W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05328":null,"YNL253W":null},"has_protein_features":false,"name":"TEX1","ortholog_annotations":[{"gene_uniquename":"YNL253W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05328","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in mRNA export; component of the transcription export (TREX) complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005197","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL253W"}


id: YNL254C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RTC4","product":"Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","secondary_identifier":"SGD:S000005198","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL254C"}


id: YNL255C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02043":null,"YNL255C":null},"has_protein_features":false,"name":"GIS2","ortholog_annotations":[{"gene_uniquename":"YNL255C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02043","reference_uniquename":"PMID:29761456"}],"product":"Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005199","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL255C"}


id: YNL256W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00815":null,"YNL256W":null},"has_protein_features":false,"name":"FOL1","ortholog_annotations":[{"gene_uniquename":"YNL256W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00815","reference_uniquename":"PMID:29761456"}],"product":"Multifunctional enzyme of the folic acid biosynthesis pathway; has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005200","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL256W"}


id: YNL257C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03247":null,"YNL257C":null},"has_protein_features":false,"name":"SIP3","ortholog_annotations":[{"gene_uniquename":"YNL257C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03247","reference_uniquename":"PMID:29761456"}],"product":"Putative sterol transfer protein; has a probable role in retrograde transport of sterols from the plasma membrane to the ER; co-localizes to puncta in the cortical ER with Ysp2p; contains GRAM, StART-like (VASt) and two PH-like domains; one of 6 StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; previously identified as a transcription cofactor that interacts with DNA-bound Snf1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005201","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL257C"}


id: YNL258C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DSL1","product":"Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; mediates Sey1p-independent homotypic ER fusion; forms Dsl1 tethering complex with Sec39p and Tip20p that forms a stable complex with ER SNAREs Sec20p, Ufe1p and Use1p and is functionally conserved from yeast to mammalian cells; component of the ER target site that interacts with coatomer; interacts with different subunits of COPI vesicle coat; interacts with Cin5p; homolog of fly and human ZW10 gene","secondary_identifier":"SGD:S000005202","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL258C"}


id: YNL259C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03231":null,"YNL259C":null},"has_protein_features":false,"name":"ATX1","ortholog_annotations":[{"gene_uniquename":"YNL259C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03231","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic copper metallochaperone; transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake; human homolog ATOX1 can complement yeast atx1 mutant; overexpression of human ATOX1 suppresses lysine auxotrophy of the yeast sod1 null mutant, as does overexpression of yeast ATX1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005203","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL259C"}


id: YNL260C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02745":null,"YNL260C":null},"has_protein_features":false,"name":"LTO1","ortholog_annotations":[{"gene_uniquename":"YNL260C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02745","reference_uniquename":"PMID:29761456"}],"product":"Substrate-specific adaptor protein involved in apo-Rli1p maturation; subunit of the Yae1-Lto1 complex, recruiting apo-Rli1p to the CIA targeting complex, facilitating the insertion of an Fe/S cluster by the Fe-S biosynthetic machinery; deca-GX3 motif crucial for complex formation; essential for aerobic but not anaerobic growth; homolog of human ORAOV1, which is overexpressed in solid tumors; co-expression of ORAOV1 and YAE1 homolog YAE1D1 restores growth and Rli1p maturation after LTO1 depletion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005204","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL260C"}


id: YNL261W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03451":null,"YNL261W":null},"has_protein_features":false,"name":"ORC5","ortholog_annotations":[{"gene_uniquename":"YNL261W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03451","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005205","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL261W"}


id: YNL262W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02908":null,"YNL262W":null},"has_protein_features":false,"name":"POL2","ortholog_annotations":[{"gene_uniquename":"YNL262W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02908","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of DNA polymerase (II) epsilon; a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; participates in leading-strand synthesis during DNA replication; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005206","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL262W"}


id: YNL263C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01642":null,"YNL263C":null},"has_protein_features":false,"name":"YIF1","ortholog_annotations":[{"gene_uniquename":"YNL263C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01642","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein; required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005207","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL263C"}


id: YNL264C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03721":null,"YNL264C":null},"has_protein_features":false,"name":"PDR17","ortholog_annotations":[{"gene_uniquename":"YNL264C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03721","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol transfer protein (PITP); downregulates Plb1p-mediated turnover of phosphatidylcholine; forms a complex with Psd2p which appears essential for maintenance of vacuolar PE levels; found in the cytosol and microsomes; homologous to Pdr16p; deletion affects phospholipid composition","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005208","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL264C"}


id: YNL265C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05303":null,"YNL265C":null},"has_protein_features":false,"name":"IST1","ortholog_annotations":[{"gene_uniquename":"YNL265C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05303","reference_uniquename":"PMID:29761456"}],"product":"Protein with positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005209","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL265C"}


id: YNL266W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C","secondary_identifier":"SGD:S000005210","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL266W"}


id: YNL267W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05330":null,"YNL267W":null},"has_protein_features":false,"name":"PIK1","ortholog_annotations":[{"gene_uniquename":"YNL267W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05330","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol 4-kinase; catalyzes the first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton; required for autophagosome formation during autophagy and for lipophagy in both stationary phase cells and during nitrogen starvation; may control nonselective autophagy and mitophagy through trafficking of Atg9p; localizes to the nucleus and to the trans-Golgi network","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005211","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL267W"}


id: YNL268W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YNL268W":null},"has_protein_features":false,"name":"LYP1","ortholog_annotations":[{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005212","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL268W"}


id: YNL269W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BSC4","product":"Protein of unknown function; protein-coding gene that evolved de novo via a series of point mutations in noncoding sequence; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p; may be involved in DNA repair pathway during stationary phase and contribute to robustness of cells when shifted to a nutrient-poor environment","secondary_identifier":"SGD:S000005213","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL269W"}


id: YNL270C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YNL270C":null},"has_protein_features":false,"name":"ALP1","ortholog_annotations":[{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005214","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL270C"}


id: YNL271C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00279":null,"YNL271C":null},"has_protein_features":false,"name":"BNI1","ortholog_annotations":[{"gene_uniquename":"YNL271C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00279","reference_uniquename":"PMID:29761456"}],"product":"Formin; polarisome component; nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables; recruited to the division site in a Glc7p/Ref2p dependent manner following release of Bnr1p; functionally redundant with BNR1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005215","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL271C"}


id: YNL272C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02368":null,"YNL272C":null},"has_protein_features":false,"name":"SEC2","ortholog_annotations":[{"gene_uniquename":"YNL272C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02368","reference_uniquename":"PMID:29761456"}],"product":"Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005216","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL272C"}


id: YNL273W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02724":null,"YNL273W":null},"has_protein_features":false,"name":"TOF1","ortholog_annotations":[{"gene_uniquename":"YNL273W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02724","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005217","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL273W"}


id: YNL274C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00281":null,"SJAG_01432":null,"YNL274C":null},"has_protein_features":false,"name":"GOR1","ortholog_annotations":[{"gene_uniquename":"YNL274C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00281","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL274C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01432","reference_uniquename":"PMID:29761456"}],"product":"Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005218","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL274C"}


id: YNL275W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01183":null,"YNL275W":null},"has_protein_features":false,"name":"BOR1","ortholog_annotations":[{"gene_uniquename":"YNL275W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01183","reference_uniquename":"PMID:29761456"}],"product":"Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005219","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL275W"}


id: YNL276C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W","secondary_identifier":"SGD:S000005220","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL276C"}


id: YNL277W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00395":null,"YNL277W":null},"has_protein_features":false,"name":"MET2","ortholog_annotations":[{"gene_uniquename":"YNL277W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00395","reference_uniquename":"PMID:29761456"}],"product":"L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL277W"}


id: YNL277W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028852","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL277W-A"}


id: YNL278W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02878":null,"YNL278W":null},"has_protein_features":false,"name":"CAF120","ortholog_annotations":[{"gene_uniquename":"YNL278W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02878","reference_uniquename":"PMID:29761456"}],"product":"Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; contains a PH-like domain; CAF120 has a paralog, SKG3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005222","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL278W"}


id: YNL279W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00870":null,"YNL279W":null},"has_protein_features":false,"name":"PRM1","ortholog_annotations":[{"gene_uniquename":"YNL279W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00870","reference_uniquename":"PMID:29761456"}],"product":"Pheromone-regulated multispanning membrane protein; involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL279W"}


id: YNL280C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04810":null,"YNL280C":null},"has_protein_features":false,"name":"ERG24","ortholog_annotations":[{"gene_uniquename":"YNL280C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04810","reference_uniquename":"PMID:29761456"}],"product":"C-14 sterol reductase; acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL280C"}


id: YNL281W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HCH1","product":"Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; role in regulating Hsp90 inhibitor drug sensitivity; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000005225","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL281W"}


id: YNL282W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02553":null,"YNL282W":null},"has_protein_features":false,"name":"POP3","ortholog_annotations":[{"gene_uniquename":"YNL282W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02553","reference_uniquename":"PMID:29761456"}],"product":"Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005226","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL282W"}


id: YNL283C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02258":null,"YNL283C":null},"has_protein_features":false,"name":"WSC2","ortholog_annotations":[{"gene_uniquename":"YNL283C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02258","reference_uniquename":"PMID:29761456"}],"product":"Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity and recovery from heat shock; required for the arrest of secretion response; WSC2 has a paralog, WSC3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005227","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL283C"}


id: YNL284C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03459":null,"YNL284C":null},"has_protein_features":false,"name":"MRPL10","ortholog_annotations":[{"gene_uniquename":"YNL284C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03459","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005228","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL284C"}


id: YNL285W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005229","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL285W"}


id: YNL286W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01452":null,"YNL286W":null},"has_protein_features":false,"name":"CUS2","ortholog_annotations":[{"gene_uniquename":"YNL286W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01452","reference_uniquename":"PMID:29761456"}],"product":"Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; regulates toggling of the U2 snRNA stem II region between different structures; contains two RNA recognition motifs (RRMs)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL286W"}


id: YNL287W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01508":null,"YNL287W":null},"has_protein_features":false,"name":"SEC21","ortholog_annotations":[{"gene_uniquename":"YNL287W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01508","reference_uniquename":"PMID:29761456"}],"product":"Gamma subunit of coatomer; coatomer is a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL287W"}


id: YNL288W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00285":null,"YNL288W":null},"has_protein_features":false,"name":"CAF40","ortholog_annotations":[{"gene_uniquename":"YNL288W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00285","reference_uniquename":"PMID:29761456"}],"product":"Component of the CCR4-NOT transcriptional complex; evolutionarily conserved; involved in controlling mRNA initiation, elongation, and degradation; binds Cdc39p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL288W"}


id: YNL289W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PCL1","product":"Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth","secondary_identifier":"SGD:S000005233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL289W"}


id: YNL290W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02182":null,"YNL290W":null},"has_protein_features":false,"name":"RFC3","ortholog_annotations":[{"gene_uniquename":"YNL290W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02182","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL290W"}


id: YNL291C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02877":null,"YNL291C":null},"has_protein_features":false,"name":"MID1","ortholog_annotations":[{"gene_uniquename":"YNL291C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02877","reference_uniquename":"PMID:29761456"}],"product":"Stretch-activated Ca2+-permeable cation channel; required for Ca2+ influx stimulated by mating pheromones and some abiotic stresses; sensor of compressive mechanical stress; N-glycosylated membrane protein of the ER and plasma membrane; interacts with Cch1p; oligomerizes; is an alpha2/delta-like protein and participates in the generation of stretch-activated Ca2+-permeable cation channel activity when expressed in mammalian cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL291C"}


id: YNL292W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04065":null,"YNL292W":null},"has_protein_features":false,"name":"PUS4","ortholog_annotations":[{"gene_uniquename":"YNL292W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04065","reference_uniquename":"PMID:29761456"}],"product":"Pseudouridine synthase; catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; also responsible for pseudouracil modification of some mRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL292W"}


id: YNL293W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01048":null,"YNL293W":null},"has_protein_features":false,"name":"MSB3","ortholog_annotations":[{"gene_uniquename":"YNL293W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01048","reference_uniquename":"PMID:29761456"}],"product":"Rab GTPase-activating protein; regulates endocytosis via inactivation of Vps21p at endosomes and vacuole fusion via inactivation of Ypt7p at vacuoles; also acts on Ypt52p and Sec4p; localizes to plasma membrane, sites of polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; similar to TBC-domain Tre2 oncogene; MSB3 has a paralog, MSB4, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL293W"}


id: YNL294C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RIM21","product":"pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH","secondary_identifier":"SGD:S000005238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL294C"}


id: YNL295W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00077":null,"YNL295W":null},"has_protein_features":false,"name":"MRX6","ortholog_annotations":[{"gene_uniquename":"YNL295W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00077","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosome-associated protein; regulates mitochondrial DNA copy number and the size and distribution of mtDNA nucleoids; subunit of a complex containing Pet20p, Mam33p, and Pim1p that may regulate mtDNA replication; member of the PET20 domain-containing protein family; forms foci that partially co-localize with mtDNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL295W"}


id: YNL296W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog","secondary_identifier":"SGD:S000005240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL296W"}


id: YNL297C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01030":null,"YNL297C":null},"has_protein_features":false,"name":"MON2","ortholog_annotations":[{"gene_uniquename":"YNL297C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01030","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in endocytosis and vacuole integrity; peripheral membrane protein; interacts with and negatively regulates Arl1p; localizes to the endosome; member of the Sec7p family of proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL297C"}


id: YNL298W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CLA4","product":"Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL298W"}


id: YNL299W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01176":null,"YNL299W":null},"has_protein_features":false,"name":"TRF5","ortholog_annotations":[{"gene_uniquename":"YNL299W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01176","reference_uniquename":"PMID:29761456"}],"product":"Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL299W"}


id: YNL300W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TOS6","product":"Glycosylphosphatidylinositol-dependent cell wall protein; expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid","secondary_identifier":"SGD:S000005244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL300W"}


id: YNL301C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02597":null,"SJAG_03335":null,"YNL301C":null},"has_protein_features":false,"name":"RPL18B","ortholog_annotations":[{"gene_uniquename":"YNL301C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02597","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL301C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03335","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL301C"}


id: YNL302C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01296":null,"SJAG_02335":null,"YNL302C":null},"has_protein_features":false,"name":"RPS19B","ortholog_annotations":[{"gene_uniquename":"YNL302C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL302C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02335","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19B has a paralog, RPS19A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL302C"}


id: YNL303W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL303W"}


id: YNL304W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YPT11","product":"Rab GTPase; Myo2p-binding protein implicated in mother-to-bud transport of cortical endoplasmic reticulum (ER), late Golgi, and mitochondria during cell division; function is regulated at multiple levels; abundance of active Ypt11p forms is controlled by phosphorylation status and degradation; normally a low-abundance protein whose ER localization is only detected when protein is highly over expressed","secondary_identifier":"SGD:S000005248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL304W"}


id: YNL305C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04471":null,"YNL305C":null},"has_protein_features":false,"name":"BXI1","ortholog_annotations":[{"gene_uniquename":"YNL305C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04471","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL305C"}


id: YNL306W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02777":null,"YNL306W":null},"has_protein_features":false,"name":"MRPS18","ortholog_annotations":[{"gene_uniquename":"YNL306W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02777","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL306W"}


id: YNL307C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00718":null,"SJAG_05304":null,"YNL307C":null},"has_protein_features":false,"name":"MCK1","ortholog_annotations":[{"gene_uniquename":"YNL307C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00718","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL307C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05304","reference_uniquename":"PMID:29761456"}],"product":"Dual-specificity ser/thr and tyrosine protein kinase; roles in chromosome segregation, meiotic entry, genome stability, phosphorylation-dependent protein degradation (Rcn1p and Cdc6p), inhibition of protein kinase A, transcriptional regulation, inhibition of RNA pol III, calcium stress and inhibition of Clb2p-Cdc28p after nuclear division; MCK1 has a paralog, YGK3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL307C"}


id: YNL308C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00965":null,"YNL308C":null},"has_protein_features":false,"name":"KRI1","ortholog_annotations":[{"gene_uniquename":"YNL308C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00965","reference_uniquename":"PMID:29761456"}],"product":"Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL308C"}


id: YNL309W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"STB1","product":"Protein with role in regulation of MBF-specific transcription at Start; phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p, which is required for Stb1p function; expression is cell-cycle regulated; STB1 has a paralog, YOL131W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL309W"}


id: YNL310C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04336":null,"YNL310C":null},"has_protein_features":false,"name":"ZIM17","ortholog_annotations":[{"gene_uniquename":"YNL310C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04336","reference_uniquename":"PMID:29761456"}],"product":"Protein co-chaperone with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix; required for the maintenance of Ssc1p solubility and assists in the functional interaction of Ssc1p with substrate proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL310C"}


id: YNL311C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SKP2","product":"F-box protein of unknown function; predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments","secondary_identifier":"SGD:S000005255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL311C"}


id: YNL312W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01698":null,"YNL312W":null},"has_protein_features":false,"name":"RFA2","ortholog_annotations":[{"gene_uniquename":"YNL312W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01698","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; in concert with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication s","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL312W"}


id: YNL313C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01291":null,"YNL313C":null},"has_protein_features":false,"name":"EMW1","ortholog_annotations":[{"gene_uniquename":"YNL313C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01291","reference_uniquename":"PMID:29761456"}],"product":"Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005257","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL313C"}


id: YNL314W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DAL82","product":"Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain","secondary_identifier":"SGD:S000005258","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL314W"}


id: YNL315C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04899":null,"YNL315C":null},"has_protein_features":false,"name":"ATP11","ortholog_annotations":[{"gene_uniquename":"YNL315C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04899","reference_uniquename":"PMID:29761456"}],"product":"Molecular chaperone; required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; N-terminally propionylated in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005259","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL315C"}


id: YNL316C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03124":null,"YNL316C":null},"has_protein_features":false,"name":"PHA2","ortholog_annotations":[{"gene_uniquename":"YNL316C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03124","reference_uniquename":"PMID:29761456"}],"product":"Prephenate dehydratase; catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005260","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL316C"}


id: YNL317W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01175":null,"YNL317W":null},"has_protein_features":false,"name":"PFS2","ortholog_annotations":[{"gene_uniquename":"YNL317W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01175","reference_uniquename":"PMID:29761456"}],"product":"Integral subunit of the pre-mRNA CPF complex; the cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005261","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL317W"}


id: YNL318C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04905":null,"YNL318C":null},"has_protein_features":false,"name":"HXT14","ortholog_annotations":[{"gene_uniquename":"YNL318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Protein with similarity to hexose transporter family members; expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005262","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL318C"}


id: YNL319W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HXT14","secondary_identifier":"SGD:S000005263","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL319W"}


id: YNL320W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00774":null,"YNL320W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNL320W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00774","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005264","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL320W"}


id: YNL321W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04028":null,"YNL321W":null},"has_protein_features":false,"name":"VNX1","ortholog_annotations":[{"gene_uniquename":"YNL321W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04028","reference_uniquename":"PMID:29761456"}],"product":"Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005265","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL321W"}


id: YNL322C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"KRE1","product":"Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor","secondary_identifier":"SGD:S000005266","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL322C"}


id: YNL323W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02516":null,"SJAG_03050":null,"YNL323W":null},"has_protein_features":false,"name":"LEM3","ortholog_annotations":[{"gene_uniquename":"YNL323W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02516","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL323W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03050","reference_uniquename":"PMID:29761456"}],"product":"Membrane protein of the plasma membrane and ER; interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane; null mutant requires tryptophan due to mislocalization of tryptophan permease Tat2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005267","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL323W"}


id: YNL324W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005268","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL324W"}


id: YNL325C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02289":null,"YNL325C":null},"has_protein_features":false,"name":"FIG4","ortholog_annotations":[{"gene_uniquename":"YNL325C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02289","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain; homologous to human FIG4, which is associated with CMT4J, a form of Charcot-Marie-Tooth disorder","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005269","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL325C"}


id: YNL326C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01299":null,"YNL326C":null},"has_protein_features":false,"name":"PFA3","ortholog_annotations":[{"gene_uniquename":"YNL326C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01299","reference_uniquename":"PMID:29761456"}],"product":"Palmitoyltransferase for Vac8p; required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005270","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL326C"}


id: YNL327W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"EGT2","product":"Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase; localizes in birth scars; required for proper cell separation after cytokinesis; expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner","secondary_identifier":"SGD:S000005271","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL327W"}


id: YNL328C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01597":null,"YNL328C":null},"has_protein_features":false,"name":"MDJ2","ortholog_annotations":[{"gene_uniquename":"YNL328C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01597","reference_uniquename":"PMID:29761456"}],"product":"Constituent of the mitochondrial import motor; associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005272","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL328C"}


id: YNL329C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02997":null,"YNL329C":null},"has_protein_features":false,"name":"PEX6","ortholog_annotations":[{"gene_uniquename":"YNL329C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02997","reference_uniquename":"PMID:29761456"}],"product":"AAA-peroxin; heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; mutations in human PEX6 can lead to severe peroxisomal disorders and early death","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005273","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL329C"}


id: YNL330C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00581":null,"YNL330C":null},"has_protein_features":false,"name":"RPD3","ortholog_annotations":[{"gene_uniquename":"YNL330C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00581","reference_uniquename":"PMID:29761456"}],"product":"Histone deacetylase, component of both the Rpd3S and Rpd3L complexes; regulates transcription, silencing, autophagy and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; Rpd3(L) recruitment to the subtelomeric region is regulated by interaction with the arginine methyltransferase, Hmt1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005274","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL330C"}


id: YNL331C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AAD14","product":"Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family","secondary_identifier":"SGD:S000005275","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL331C"}


id: YNL332W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04866":null,"YNL332W":null},"has_protein_features":false,"name":"THI12","ortholog_annotations":[{"gene_uniquename":"YNL332W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04866","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005276","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL332W"}


id: YNL333W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00283":null,"YNL333W":null},"has_protein_features":false,"name":"SNZ2","ortholog_annotations":[{"gene_uniquename":"YNL333W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00283","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in thiamine and pyridoxine biosynthesis; member of a stationary phase-induced gene family where transcriptional induction precedes the diauxic shift; induced in the absence of thiamin in a Thi2/3p-dependent manner and repressed in its presence; forms a co-regulated gene pair with SNO2; interacts with Thi11p; paralog of SNZ1 and SNZ3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005277","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL333W"}


id: YNL334C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00691":null,"YNL334C":null},"has_protein_features":false,"name":"SNO2","ortholog_annotations":[{"gene_uniquename":"YNL334C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00691","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005278","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL334C"}


id: YNL335W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DDI2","product":"Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI3 and Ddi3p","secondary_identifier":"SGD:S000005279","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL335W"}


id: YNL336W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COS1","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000005280","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL336W"}


id: YNL337W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005281","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL337W"}


id: YNL338W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is a telomeric X element core sequence on the left arm of chromosome XIV","secondary_identifier":"SGD:S000005282","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL338W"}


id: YNL339C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YRF1-6","product":"Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p","secondary_identifier":"SGD:S000005283","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL339C"}


id: YNL339W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028703","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL339W-A"}


id: YNL339W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL339W-B"}


id: YNR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01922":null,"YNR001C":null},"has_protein_features":false,"name":"CIT1","ortholog_annotations":[{"gene_uniquename":"YNR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01922","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial citrate synthase; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate, which is the first and rate-limiting step of the TCA cycle; transcription subject to glucose repression; CIT1 has a paralog, CIT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005284","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR001C"}


id: YNR001W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by homology","secondary_identifier":"SGD:S000007625","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR001W-A"}


id: YNR002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01505":null,"YNR002C":null},"has_protein_features":false,"name":"ATO2","ortholog_annotations":[{"gene_uniquename":"YNR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01505","reference_uniquename":"PMID:29761456"}],"product":"Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005285","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR002C"}


id: YNR003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03181":null,"YNR003C":null},"has_protein_features":false,"name":"RPC34","ortholog_annotations":[{"gene_uniquename":"YNR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03181","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005286","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR003C"}


id: YNR003W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene RPC34/YNR003C","secondary_identifier":"SGD:S000028705","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR003W-A"}


id: YNR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SWM2","product":"Protein with a role in snRNA and snoRNA cap trimethylation; interacts with Tgs1p and shows similar phenotypes; required for trimethylation of the caps of spliceosomal snRNAs and the U3 snoRNA, and for efficient 3' end processing of U3 snoRNA; may act as a specificity factor for Tgs1p","secondary_identifier":"SGD:S000005287","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR004W"}


id: YNR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005288","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR005C"}


id: YNR006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03250":null,"YNR006W":null},"has_protein_features":false,"name":"VPS27","ortholog_annotations":[{"gene_uniquename":"YNR006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03250","reference_uniquename":"PMID:29761456"}],"product":"Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005289","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR006W"}


id: YNR007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01561":null,"YNR007C":null},"has_protein_features":false,"name":"ATG3","ortholog_annotations":[{"gene_uniquename":"YNR007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01561","reference_uniquename":"PMID:29761456"}],"product":"E2-like enzyme; involved in autophagy and cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p regulated by acetylation by NuA4 histone acetyltransferase Esa1p while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p; Atg12p-Atg5p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005290","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR007C"}


id: YNR008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03162":null,"YNR008W":null},"has_protein_features":false,"name":"LRO1","ortholog_annotations":[{"gene_uniquename":"YNR008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03162","reference_uniquename":"PMID:29761456"}],"product":"Acyltransferase that converts diacylglycerol to triacylglycerol (TGA); one of several acyltransferases that contribute to TGA synthesis; relocates from ER to nuclear membrane in response cell cycle and starvation signals; Lro1p and Dga1p can O-acylate ceramides; putative homolog of human lecithin cholesterol acyltransferase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005291","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR008W"}


id: YNR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04381":null,"YNR009W":null},"has_protein_features":false,"name":"NRM1","ortholog_annotations":[{"gene_uniquename":"YNR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04381","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional co-repressor of MBF-regulated gene expression; Nrm1p associates stably with promoters via MCB binding factor (MBF) to repress transcription upon exit from G1 phase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005292","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR009W"}


id: YNR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03590":null,"YNR010W":null},"has_protein_features":false,"name":"CSE2","ortholog_annotations":[{"gene_uniquename":"YNR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03590","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Middle domain of mediator; required for regulation of RNA polymerase II activity; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005293","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR010W"}


id: YNR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01315":null,"YNR011C":null},"has_protein_features":false,"name":"PRP2","ortholog_annotations":[{"gene_uniquename":"YNR011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01315","reference_uniquename":"PMID:29761456"}],"product":"RNA-dependent DExD/H-box ATPase; required for activation of spliceosome before first transesterification step in RNA splicing; implicated in rearranging and proofreading snRNA structure in catalytic activation of spliceosome; ortholog of human protein DHX16","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005294","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR011C"}


id: YNR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03708":null,"YNR012W":null},"has_protein_features":false,"name":"URK1","ortholog_annotations":[{"gene_uniquename":"YNR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03708","reference_uniquename":"PMID:29761456"}],"product":"Uridine/cytidine kinase; component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005295","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR012W"}


id: YNR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01059":null,"YNR013C":null},"has_protein_features":false,"name":"PHO91","ortholog_annotations":[{"gene_uniquename":"YNR013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01059","reference_uniquename":"PMID:29761456"}],"product":"Low-affinity vacuolar phosphate transporter; exports phosphate from the vacuolar lumen to the cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of the PHO pathway; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005296","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR013C"}


id: YNR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005297","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR014W"}


id: YNR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03236":null,"YNR015W":null},"has_protein_features":false,"name":"SMM1","ortholog_annotations":[{"gene_uniquename":"YNR015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03236","reference_uniquename":"PMID:29761456"}],"product":"Dihydrouridine synthase; member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005298","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR015W"}


id: YNR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03313":null,"YNR016C":null},"has_protein_features":false,"name":"ACC1","ortholog_annotations":[{"gene_uniquename":"YNR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03313","reference_uniquename":"PMID:29761456"}],"product":"Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availability of acetyl-CoA; rate-limiting step for de novo biosynthesis of long-chain fatty acids; translational regulation in response to nutrients and cell cycle stage depends on its upstream ORF; ACC1 has a paralog, HFA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005299","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR016C"}


id: YNR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04218":null,"YNR017W":null},"has_protein_features":false,"name":"TIM23","ortholog_annotations":[{"gene_uniquename":"YNR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04218","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the TIM23 complex; involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel; TIM23 complex is short for the translocase of the inner mitochondrial membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005300","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR017W"}


id: YNR018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03337":null,"YNR018W":null},"has_protein_features":false,"name":"RCF2","ortholog_annotations":[{"gene_uniquename":"YNR018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03337","reference_uniquename":"PMID:29761456"}],"product":"Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005301","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR018W"}


id: YNR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04049":null,"SJAG_04059":null,"YNR019W":null},"has_protein_features":false,"name":"ARE2","ortholog_annotations":[{"gene_uniquename":"YNR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04049","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04059","reference_uniquename":"PMID:29761456"}],"product":"Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005302","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR019W"}


id: YNR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01838":null,"YNR020C":null},"has_protein_features":false,"name":"ATP23","ortholog_annotations":[{"gene_uniquename":"YNR020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01838","reference_uniquename":"PMID:29761456"}],"product":"Putative metalloprotease of the mitochondrial inner membrane; required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005303","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR020C"}


id: YNR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03930":null,"YNR021W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03930","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005304","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR021W"}


id: YNR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04207":null,"YNR022C":null},"has_protein_features":false,"name":"MRPL50","ortholog_annotations":[{"gene_uniquename":"YNR022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04207","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005305","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR022C"}


id: YNR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00739":null,"YNR023W":null},"has_protein_features":false,"name":"SNF12","ortholog_annotations":[{"gene_uniquename":"YNR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00739","reference_uniquename":"PMID:29761456"}],"product":"73 kDa subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive; SNF12 has a paralog, RSC6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005306","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR023W"}


id: YNR024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01431":null,"YNR024W":null},"has_protein_features":false,"name":"MPP6","ortholog_annotations":[{"gene_uniquename":"YNR024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01431","reference_uniquename":"PMID:29761456"}],"product":"Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005307","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR024W"}


id: YNR025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase","secondary_identifier":"SGD:S000005308","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR025C"}


id: YNR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04615":null,"YNR026C":null},"has_protein_features":false,"name":"SEC12","ortholog_annotations":[{"gene_uniquename":"YNR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04615","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF); activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER; SEC12 has a paralog, SED4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005309","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR026C"}


id: YNR027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00252":null,"SJAG_01383":null,"YNR027W":null},"has_protein_features":false,"name":"BUD17","ortholog_annotations":[{"gene_uniquename":"YNR027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00252","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01383","reference_uniquename":"PMID:29761456"}],"product":"Putative pyridoxal kinase; a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005310","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR027W"}


id: YNR028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CPR8","product":"Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; CPR8 has a paralog, CPR4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005311","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR028W"}


id: YNR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00923":null,"YNR029C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00923","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; deletion confers reduced fitness in saline","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005312","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR029C"}


id: YNR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00437":null,"YNR030W":null},"has_protein_features":false,"name":"ALG12","ortholog_annotations":[{"gene_uniquename":"YNR030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00437","reference_uniquename":"PMID:29761456"}],"product":"Alpha-1,6-mannosyltransferase localized to the ER; responsible for addition of alpha-1,6 mannose to dolichol-linked Man7GlcNAc2; acts in the dolichol pathway for N-glycosylation; human homolog ALG12 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005313","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR030W"}


id: YNR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03384":null,"SJAG_04777":null,"YNR031C":null},"has_protein_features":false,"name":"SSK2","ortholog_annotations":[{"gene_uniquename":"YNR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03384","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04777","reference_uniquename":"PMID:29761456"}],"product":"MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress; a HOG-independent function of Ssk2p mediates the calcium-sensitive phenotype of the ptp2 msg5 double disruptant; SSK2 has a paralog, SSK22, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005314","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR031C"}


id: YNR032C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03849":null,"YNR032C-A":null},"has_protein_features":false,"name":"HUB1","ortholog_annotations":[{"gene_uniquename":"YNR032C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03849","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR032C-A"}


id: YNR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01790":null,"YNR032W":null},"has_protein_features":false,"name":"PPG1","ortholog_annotations":[{"gene_uniquename":"YNR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01790","reference_uniquename":"PMID:29761456"}],"product":"Serine protein phosphatase involved in formation of FAR complex; inhibits mitophagy by dephosphorylating Atg32p; required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005315","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR032W"}


id: YNR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02408":null,"YNR033W":null},"has_protein_features":false,"name":"ABZ1","ortholog_annotations":[{"gene_uniquename":"YNR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02408","reference_uniquename":"PMID:29761456"}],"product":"Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005316","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR033W"}


id: YNR034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01824":null,"YNR034W":null},"has_protein_features":false,"name":"SOL1","ortholog_annotations":[{"gene_uniquename":"YNR034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01824","reference_uniquename":"PMID:29761456"}],"product":"Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005317","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR034W"}


id: YNR034W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"EGO4","product":"Protein of unknown function; expressed during diauxic shift and stationary phase, and negatively regulated by glucose; expression is regulated by Msn2p/Msn4p; overexpression slows down progression through meiosis and improves fermentative efficiency; YNR034W-A has a paralog, YCR075W-A, that arose from the whole genome duplication","secondary_identifier":"SGD:S000007525","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR034W-A"}


id: YNR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01384":null,"YNR035C":null},"has_protein_features":false,"name":"ARC35","ortholog_annotations":[{"gene_uniquename":"YNR035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01384","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005318","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR035C"}


id: YNR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04173":null,"SJAG_04494":null,"YNR036C":null},"has_protein_features":false,"name":"MRPS12","ortholog_annotations":[{"gene_uniquename":"YNR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04173","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04494","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005319","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR036C"}


id: YNR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04918":null,"YNR037C":null},"has_protein_features":false,"name":"RSM19","ortholog_annotations":[{"gene_uniquename":"YNR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04918","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S19 ribosomal protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005320","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR037C"}


id: YNR038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03479":null,"YNR038W":null},"has_protein_features":false,"name":"DBP6","ortholog_annotations":[{"gene_uniquename":"YNR038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03479","reference_uniquename":"PMID:29761456"}],"product":"Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family; human homolog DDX51 complements yeast dbp6 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005321","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR038W"}


id: YNR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03528":null,"YNR039C":null},"has_protein_features":false,"name":"ZRG17","ortholog_annotations":[{"gene_uniquename":"YNR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03528","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005322","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR039C"}


id: YNR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MRX15","product":"Membrane-associated mitoribosome receptor; involved along with Mba1p in the cotranslational insertion of nascent polypeptide chains into the inner mitochondrial membrane; associates with the mitochondrial large ribosomal subunit and nascent polypeptide chains; null mutant displays increased tolerance to mistranslation-induced proteotoxic stress; localizes to the inner mitochondrial membrane","secondary_identifier":"SGD:S000005323","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR040W"}


id: YNR041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06603":null,"YNR041C":null},"has_protein_features":false,"name":"COQ2","ortholog_annotations":[{"gene_uniquename":"YNR041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06603","reference_uniquename":"PMID:29761456"}],"product":"Para hydroxybenzoate polyprenyl transferase; catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis; human COQ2, mutations in which are implicated in an increased risk of mutiple-system atrophy, can complement a yeast coq2 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005324","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR041C"}


id: YNR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2","secondary_identifier":"SGD:S000005325","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR042W"}


id: YNR043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03349":null,"YNR043W":null},"has_protein_features":false,"name":"MVD1","ortholog_annotations":[{"gene_uniquename":"YNR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03349","reference_uniquename":"PMID:29761456"}],"product":"Mevalonate pyrophosphate decarboxylase; essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005326","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR043W"}


id: YNR044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AGA1","product":"Anchorage subunit of a-agglutinin of a-cells; highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds; AGA1 has a paralog, FIG2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005327","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR044W"}


id: YNR045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PET494","product":"Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane","secondary_identifier":"SGD:S000005328","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR045W"}


id: YNR046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04890":null,"YNR046W":null},"has_protein_features":false,"name":"TRM112","ortholog_annotations":[{"gene_uniquename":"YNR046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04890","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in methylation of tRNA, rRNA, and translation factors; also involved in ribosome biogenesis; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; N7-methylates G1575 of 18S rRNA as complex with Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; relative distribution to the nucleus increases upon DNA replication stress; functional homolog of human TRMT112","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005329","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR046W"}


id: YNR047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03209":null,"SJAG_04734":null,"YNR047W":null},"has_protein_features":false,"name":"FPK1","ortholog_annotations":[{"gene_uniquename":"YNR047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03209","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04734","reference_uniquename":"PMID:29761456"}],"product":"Ser/Thr protein kinase; phosphorylates several aminophospholipid translocase family members, regulating phospholipid translocation and membrane asymmetry; phosphorylates and inhibits the protein kinase Akl1p, stimulating endocytosis; phosphorylates and inhibits upstream inhibitory kinase Ypk1p; localizes to the cytoplasm, early endosome/TGN, the plasma membrane and the shmoo tip; redundant role with KIN82 in the mating pheromone response; activity stimulated by Gin4p kinase and sphingolipid MIPC","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005330","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR047W"}


id: YNR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02516":null,"SJAG_03050":null,"YNR048W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02516","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03050","reference_uniquename":"PMID:29761456"}],"product":"Potential noncatalytic subunit for phospholipid translocase Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005331","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR048W"}


id: YNR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00280":null,"YNR049C":null},"has_protein_features":false,"name":"MSO1","ortholog_annotations":[{"gene_uniquename":"YNR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00280","reference_uniquename":"PMID:29761456"}],"product":"Lipid-interacting protein in SNARE complex assembly machinery; acts at late step in secretion; interacts with membranes through two distinct binding sites; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; N-terminus closely associates with plasma membrane, C-terminus colocalizes with Sec4p on intracellular membranes; relocalizes from bud neck to nucleus upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005332","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR049C"}


id: YNR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01061":null,"YNR050C":null},"has_protein_features":false,"name":"LYS9","ortholog_annotations":[{"gene_uniquename":"YNR050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01061","reference_uniquename":"PMID:29761456"}],"product":"Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005333","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR050C"}


id: YNR051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02663":null,"YNR051C":null},"has_protein_features":false,"name":"BRE5","ortholog_annotations":[{"gene_uniquename":"YNR051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02663","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin protease cofactor; forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the ER and Golgi compartments, deubiquitinating COPII and COPI vesicle coat constituents, Sec23p and Sec27p; involved along with Ubp3p in the steady-state retention of Golgi membrane proteins, such as glycosyltransferases; null is sensitive to brefeldin A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005334","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR051C"}


id: YNR052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04407":null,"YNR052C":null},"has_protein_features":false,"name":"POP2","ortholog_annotations":[{"gene_uniquename":"YNR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04407","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation; exonuclease of the DEDD superfamily","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005335","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR052C"}


id: YNR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01391":null,"YNR053C":null},"has_protein_features":false,"name":"NOG2","ortholog_annotations":[{"gene_uniquename":"YNR053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01391","reference_uniquename":"PMID:29761456"}],"product":"Putative GTPase; associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; recruited by ribosomal proteins L17, L35, and L37 to assembling ribosomes after 27SB pre-rRNA is generated, immediately preceding removal of ITS2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005336","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR053C"}


id: YNR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04524":null,"YNR054C":null},"has_protein_features":false,"name":"ESF2","ortholog_annotations":[{"gene_uniquename":"YNR054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04524","reference_uniquename":"PMID:29761456"}],"product":"Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005337","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR054C"}


id: YNR055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04134":null,"YNR055C":null},"has_protein_features":false,"name":"HOL1","ortholog_annotations":[{"gene_uniquename":"YNR055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04134","reference_uniquename":"PMID:29761456"}],"product":"Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005338","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR055C"}


id: YNR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BIO5","product":"Putative transmembrane protein involved in the biotin biosynthesis; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis","secondary_identifier":"SGD:S000005339","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR056C"}


id: YNR057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BIO4","product":"Dethiobiotin synthetase; catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria; expression appears to be repressed at low iron levels","secondary_identifier":"SGD:S000005340","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR057C"}


id: YNR058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00673":null,"YNR058W":null},"has_protein_features":false,"name":"BIO3","ortholog_annotations":[{"gene_uniquename":"YNR058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00673","reference_uniquename":"PMID:26896847"}],"product":"7,8-diamino-pelargonic acid aminotransferase (DAPA); catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000005341","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR058W"}


id: YNR059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MNT4","product":"Putative alpha-1,3-mannosyltransferase; not required for protein O-glycosylation; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","secondary_identifier":"SGD:S000005342","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR059W"}


id: YNR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04743":null,"YNR060W":null},"has_protein_features":false,"name":"FRE4","ortholog_annotations":[{"gene_uniquename":"YNR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Ferric reductase; reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005343","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR060W"}


id: YNR061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000005344","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR061C"}


id: YNR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PUL3","product":"Putative pulcherrimin transporter; involved in uptake of iron-transporting siderophore, pulcherrimin","secondary_identifier":"SGD:S000005345","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR062C"}


id: YNR063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PUL4","product":"Putative zinc-cluster transcription factor; involved in utilization of iron-transporting siderophore pulcherrimin","secondary_identifier":"SGD:S000005346","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR063W"}


id: YNR064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Epoxide hydrolase; member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides","secondary_identifier":"SGD:S000005347","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR064C"}


id: YNR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01488":null,"YNR065C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01488","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005348","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR065C"}


id: YNR066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative membrane-localized protein of unknown function","secondary_identifier":"SGD:S000005349","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR066C"}


id: YNR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00667":null,"SJAG_01017":null,"YNR067C":null},"has_protein_features":false,"name":"DSE4","ortholog_annotations":[{"gene_uniquename":"YNR067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00667","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01017","reference_uniquename":"PMID:29761456"}],"product":"Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005350","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR067C"}


id: YNR068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form","secondary_identifier":"SGD:S000005351","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR068C"}


id: YNR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BSC5","product":"Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro","secondary_identifier":"SGD:S000005352","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR069C"}


id: YNR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04277":null,"YNR070W":null},"has_protein_features":false,"name":"PDR18","ortholog_annotations":[{"gene_uniquename":"YNR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Transporter of the ATP-binding cassette (ABC) family; role in plasma membrane sterol incorporation; implicated in pleiotropic drug resistance; provides resistance to ethanol stress and contributes to a decreased intracellular accumulation of ethanol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005353","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR070W"}


id: YNR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative aldose 1-epimerase","secondary_identifier":"SGD:S000005354","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR071C"}


id: YNR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04905":null,"YNR072W":null},"has_protein_features":false,"name":"HXT17","ortholog_annotations":[{"gene_uniquename":"YNR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005355","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR072W"}


id: YNR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MAN2","product":"Mannitol dehydrogenase; MAN2 has a paralog, DSF1, that arose from a segmental duplication","secondary_identifier":"SGD:S000005356","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR073C"}


id: YNR074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02016":null,"YNR074C":null},"has_protein_features":false,"name":"AIF1","ortholog_annotations":[{"gene_uniquename":"YNR074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02016","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial cell death effector; translocates to the nucleus in response to apoptotic stimuli; triggers apoptosis in cells lacking HXK2; homolog of mammalian Apoptosis-Inducing Factor, putative reductase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005357","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR074C"}


id: YNR075C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028706","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR075C-A"}


id: YNR075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COS10","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000005358","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR075W"}


id: YNR076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU6","product":"Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme; identical to Pau18p","secondary_identifier":"SGD:S000005359","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR076W"}


id: YNR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function, abundance changes with carbon source","secondary_identifier":"SGD:S000005360","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR077C"}


id: YOL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PHO80","product":"Cyclin; interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling","secondary_identifier":"SGD:S000005361","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL001W"}


id: YOL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02847":null,"YOL002C":null},"has_protein_features":false,"name":"IZH2","ortholog_annotations":[{"gene_uniquename":"YOL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02847","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane receptor for plant antifungal osmotin; involved in zinc ion homeostasis, apoptosis; negatively regulates ZRT1 and other functionally divergent genes through CCCTC promoter motif (IzRE); modulates FET3 activity in iron-independent manner; affects gene expression by influencing balance of competition between Msn2p/Msn4p and Nrg1p/Nrg2p for binding to IzRE; transcription regulated by Zap1p, zinc, fatty acid levels; homolog of mammalian adiponectin receptor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005362","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL002C"}


id: YOL003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PFA4","product":"Palmitoyltransferase with autoacylation activity; required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases","secondary_identifier":"SGD:S000005363","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL003C"}


id: YOL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00441":null,"SJAG_01804":null,"SJAG_02846":null,"YOL004W":null},"has_protein_features":false,"name":"SIN3","ortholog_annotations":[{"gene_uniquename":"YOL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00441","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01804","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02846","reference_uniquename":"PMID:29761456"}],"product":"Component of both the Rpd3S and Rpd3L histone deacetylase complexes; involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005364","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL004W"}


id: YOL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04894":null,"YOL005C":null},"has_protein_features":false,"name":"RPB11","ortholog_annotations":[{"gene_uniquename":"YOL005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04894","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005365","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL005C"}


id: YOL006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05193":null,"YOL006C":null},"has_protein_features":false,"name":"TOP1","ortholog_annotations":[{"gene_uniquename":"YOL006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05193","reference_uniquename":"PMID:29761456"}],"product":"Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005366","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL006C"}


id: YOL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CSI2","product":"Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene","secondary_identifier":"SGD:S000005367","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL007C"}


id: YOL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04223":null,"YOL008W":null},"has_protein_features":false,"name":"COQ10","ortholog_annotations":[{"gene_uniquename":"YOL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04223","reference_uniquename":"PMID:29761456"}],"product":"Coenzyme Q (ubiquinone) binding protein; functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes; respiratory growth defect of the null mutant is functionally complemented by human COQ10A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005368","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL008W"}


id: YOL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03710":null,"YOL009C":null},"has_protein_features":false,"name":"MDM12","ortholog_annotations":[{"gene_uniquename":"YOL009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03710","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial outer membrane protein, ERMES complex subunit; required for transmission of mitochondria to daughter cells; required for mitophagy; may influence import and assembly of outer membrane beta-barrel proteins; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005369","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL009C"}


id: YOL010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01476":null,"YOL010W":null},"has_protein_features":false,"name":"RCL1","ortholog_annotations":[{"gene_uniquename":"YOL010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01476","reference_uniquename":"PMID:29761456"}],"product":"Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005370","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL010W"}


id: YOL011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02091":null,"SJAG_02093":null,"SJAG_03204":null,"YOL011W":null},"has_protein_features":false,"name":"PLB3","ortholog_annotations":[{"gene_uniquename":"YOL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02091","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02093","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03204","reference_uniquename":"PMID:29761456"}],"product":"Phospholipase B (lysophospholipase) involved in lipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; PLB3 has a paralog, PLB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005371","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL011W"}


id: YOL012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03047":null,"YOL012C":null},"has_protein_features":false,"name":"HTZ1","ortholog_annotations":[{"gene_uniquename":"YOL012C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03047","reference_uniquename":"PMID:29761456"}],"product":"Histone variant H2AZ; exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin; Htz1p-containing nucleosomes facilitate RNA Pol II passage by affecting correct assembly and modification status of RNA Pol II elongation complexes and by favoring efficient nucleosome remodeling","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005372","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL012C"}


id: YOL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05274":null,"YOL013C":null},"has_protein_features":false,"name":"HRD1","ortholog_annotations":[{"gene_uniquename":"YOL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05274","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) of misfolded proteins; upon autoubiquitination triggers retrotranslocation of misfolded proteins to cytosol for degradation; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005373","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL013C"}


id: YOL013W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by SAGE","secondary_identifier":"SGD:S000028811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL013W-A"}


id: YOL013W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element","secondary_identifier":"SGD:S000007252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL013W-B"}


id: YOL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; mCherry fusion protein localizes to the cytosol and nucleus","secondary_identifier":"SGD:S000005374","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL014W"}


id: YOL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IRC10","product":"Protein of unknown function; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; null mutant displays increased levels of spontaneous Rad52p foci","secondary_identifier":"SGD:S000005375","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL015W"}


id: YOL016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02858":null,"YOL016C":null},"has_protein_features":false,"name":"CMK2","ortholog_annotations":[{"gene_uniquename":"YOL016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02858","reference_uniquename":"PMID:29761456"}],"product":"Calmodulin-dependent protein kinase; negative feedback controller of calcium/calcineurin signalling pathway, also has additional Crz1-independent role in promoting calcium tolerance; amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005376","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL016C"}


id: YOL017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ESC8","product":"Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005377","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL017W"}


id: YOL018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04978":null,"YOL018C":null},"has_protein_features":false,"name":"TLG2","ortholog_annotations":[{"gene_uniquename":"YOL018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04978","reference_uniquename":"PMID:29761456"}],"product":"Syntaxin-like t-SNARE; forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; required along with VPS45 for an early step of the constitutive CVT pathway; interactions with Vps45 prevents Tlg2p degradation, and facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL018C"}


id: YOL019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01189":null,"SJAG_04058":null,"YOL019W":null},"has_protein_features":false,"name":"TOS7","ortholog_annotations":[{"gene_uniquename":"YOL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01189","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04058","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in secretion and cell wall organization; localizes to plasma membrane microdomains called MCCs (membrane compartment occupied by Can1); GFP-fusion protein localizes to the cell periphery and vacuole; Sur7/PalI family transmembrane domain (TMD) containing protein; TOS7 has a paralog, DCV1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL019W"}


id: YOL019W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028707","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL019W-A"}


id: YOL020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YOL020W":null},"has_protein_features":false,"name":"TAT2","ortholog_annotations":[{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"High affinity tryptophan and tyrosine permease; overexpression confers FK506 and FTY720 resistance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL020W"}


id: YOL021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04006":null,"YOL021C":null},"has_protein_features":false,"name":"DIS3","ortholog_annotations":[{"gene_uniquename":"YOL021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04006","reference_uniquename":"PMID:29761456"}],"product":"Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; similar to E. coli RNase R and to human DIS3, which partially complements dis3-81 heat sensitivity; mutations in Dis3p analogous to human mutations implicated in multiple myeloma impair exosome function; protein abundance increases under to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL021C"}


id: YOL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02911":null,"SJAG_03857":null,"YOL022C":null},"has_protein_features":false,"name":"TSR4","ortholog_annotations":[{"gene_uniquename":"YOL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02911","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03857","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic assembly chaperone for ribosomal protein Rps2p; co-translationally associates with the N-terminal extension of Rps2p to facilitate expression, solubility and ribosome assembly; released prior to the nuclear import of Rps2p; required for correct processing of 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in the S288C background but not in CEN.PK2; homologous to human PDCD2L and PDCD2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL022C"}


id: YOL023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02856":null,"YOL023W":null},"has_protein_features":false,"name":"IFM1","ortholog_annotations":[{"gene_uniquename":"YOL023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02856","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial translation initiation factor 2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005383","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL023W"}


id: YOL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL024W"}


id: YOL025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LAG2","product":"Protein that negatively regulates the SCF E3-ubiquitin ligase; regulates by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1","secondary_identifier":"SGD:S000005385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL025W"}


id: YOL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00569":null,"YOL026C":null},"has_protein_features":false,"name":"MIM1","ortholog_annotations":[{"gene_uniquename":"YOL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00569","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; forms a complex with Mim2p in the outer membrane that functions as cation-selective channel for translocation of positively charged precursor segments; also has a role in assembly of Tom20p into the TOM complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL026C"}


id: YOL027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01806":null,"YOL027C":null},"has_protein_features":false,"name":"MDM38","ortholog_annotations":[{"gene_uniquename":"YOL027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01806","reference_uniquename":"PMID:29761456"}],"product":"Membrane-associated mitochondrial ribosome receptor; forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; ribosome-associated protein involved in the insertion of newly synthesized proteins into the mitochondrial inner membrane; role in protein export and K+/H+ exchange; localizes to the inner mitochondrial membrane; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL027C"}


id: YOL028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YAP7","product":"Transcriptional repressor of nitric oxide oxidase; basic leucine zipper (bZIP) transcription factor; neighboring gene, YOL029C, created by frame-shift at position 708, corresponds to C-terminal part of YAP7 orthologs in other species; YAP7 has a paralog, YAP5, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL028C"}


id: YOL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; separated from neighboring gene, YAP7, by frame shift and corresponds to C-terminal part of YAP7 orthologs in other species; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens","secondary_identifier":"SGD:S000005389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL029C"}


id: YOL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00218":null,"SJAG_04483":null,"YOL030W":null},"has_protein_features":false,"name":"GAS5","ortholog_annotations":[{"gene_uniquename":"YOL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00218","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04483","reference_uniquename":"PMID:29761456"}],"product":"1,3-beta-glucanosyltransferase; has similarity to Gas1p; localizes to the cell wall","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL030W"}


id: YOL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SIL1","product":"Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; required for protein translocation into the endoplasmic reticulum (ER); homolog of Yarrowia lipolytica SLS1; GrpE-like protein","secondary_identifier":"SGD:S000005391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL031C"}


id: YOL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00586":null,"YOL032W":null},"has_protein_features":false,"name":"OPI10","ortholog_annotations":[{"gene_uniquename":"YOL032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00586","reference_uniquename":"PMID:29761456"}],"product":"Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL032W"}


id: YOL033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03071":null,"YOL033W":null},"has_protein_features":false,"name":"MSE1","ortholog_annotations":[{"gene_uniquename":"YOL033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03071","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial glutamyl-tRNA synthetase; predicted to be palmitoylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL033W"}


