# genes

id: YGL261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU11","product":"Putative protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2","secondary_identifier":"SGD:S000003230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL261C"}


id: YGL262W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene","secondary_identifier":"SGD:S000003231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL262W"}


id: YGL263W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COS12","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000003232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL263W"}


id: YGR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"EFM5","product":"S-adenosylmethionine-dependent lysine methyltransferase; involved in the trimethylation of eEF1A (Tef1p/Tef2p) at lysine 79; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in budding yeast; expresses a circular RNA; originally misclassified as a N-6-adenine specific DNA methyltransferase based on sequence similarity; both Efm5p and human ortholog N6AMT2 can methylate eEF1a from either species in vitro","secondary_identifier":"SGD:S000003233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR001C"}


id: YGR002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02385":null,"YGR002C":null},"has_protein_features":false,"name":"SWC4","ortholog_annotations":[{"gene_uniquename":"YGR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02385","reference_uniquename":"PMID:29761456"}],"product":"Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR002C"}


id: YGR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04335":null,"YGR003W":null},"has_protein_features":false,"name":"CUL3","ortholog_annotations":[{"gene_uniquename":"YGR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04335","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-protein ligase; forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR003W"}


id: YGR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEX31","product":"Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p; PEX31 has a paralog, PEX30, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR004W"}


id: YGR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04852":null,"YGR005C":null},"has_protein_features":false,"name":"TFG2","ortholog_annotations":[{"gene_uniquename":"YGR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04852","reference_uniquename":"PMID:29761456"}],"product":"TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR005C"}


id: YGR006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02455":null,"YGR006W":null},"has_protein_features":false,"name":"PRP18","ortholog_annotations":[{"gene_uniquename":"YGR006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02455","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor and component of snRNP U5; factor involved in the positioning of the 3' splice site during the second catalytic step of splicing; interacts with Slu7p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR006W"}


id: YGR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04628":null,"YGR007W":null},"has_protein_features":false,"name":"ECT1","ortholog_annotations":[{"gene_uniquename":"YGR007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04628","reference_uniquename":"PMID:29761456"}],"product":"Ethanolamine-phosphate cytidylyltransferase; catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases; inability of the null mutant to synthesize phosphatidylethanolamine and phosphatidylcholine from ethanolamine is functionally complemented by human PCYT2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR007W"}


id: YGR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"STF2","product":"Protein involved in resistance to desiccation stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to F0 sector of mitochondrial F1F0 ATPase in vitro and may modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress; STF2 has a paralog, TMA10, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR008C"}


id: YGR009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00826":null,"YGR009C":null},"has_protein_features":false,"name":"SEC9","ortholog_annotations":[{"gene_uniquename":"YGR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00826","reference_uniquename":"PMID:29761456"}],"product":"t-SNARE protein required for secretory vesicle-plasma membrane fusion; similar to but not functionally redundant with Spo20p; interacts non-exocyst bound Sec6p; SNAP-25 homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR009C"}


id: YGR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02889":null,"YGR010W":null},"has_protein_features":false,"name":"NMA2","ortholog_annotations":[{"gene_uniquename":"YGR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02889","reference_uniquename":"PMID:29761456"}],"product":"Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); homolog of human NMNAT; NMA2 has a paralog, NMA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR010W"}


id: YGR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR011W"}


id: YGR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00582":null,"SJAG_01880":null,"YGR012W":null},"has_protein_features":false,"name":"MCY1","ortholog_annotations":[{"gene_uniquename":"YGR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00582","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01880","reference_uniquename":"PMID:29761456"}],"product":"Putative cysteine synthase; localized to the mitochondrial outer membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR012W"}


id: YGR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04163":null,"YGR013W":null},"has_protein_features":false,"name":"SNU71","ortholog_annotations":[{"gene_uniquename":"YGR013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04163","reference_uniquename":"PMID:29761456"}],"product":"Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR013W"}


id: YGR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MSB2","product":"Mucin family member involved in various signaling pathways; functions as osmosensor in the Sho1p-mediated HOG pathway; functions in Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; processed into secreted and cell-associated forms by aspartyl protease Yps1p; potential Cdc28p substrate","secondary_identifier":"SGD:S000003246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR014W"}


id: YGR015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00734":null,"YGR015C":null},"has_protein_features":false,"name":"EAT1","ortholog_annotations":[{"gene_uniquename":"YGR015C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00734","reference_uniquename":"PMID:29761456"}],"product":"Ethanol acetyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR015C"}


id: YGR016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06268":null,"YGR016W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06268","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR016W"}


id: YGR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00707":null,"YGR017W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00707","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR017W"}


id: YGR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W","secondary_identifier":"SGD:S000003250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR018C"}


id: YGR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03434":null,"YGR019W":null},"has_protein_features":false,"name":"UGA1","ortholog_annotations":[{"gene_uniquename":"YGR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03434","reference_uniquename":"PMID:29761456"}],"product":"Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR019W"}


id: YGR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04015":null,"YGR020C":null},"has_protein_features":false,"name":"VMA7","ortholog_annotations":[{"gene_uniquename":"YGR020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04015","reference_uniquename":"PMID:29761456"}],"product":"Subunit F of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR020C"}


id: YGR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03550":null,"YGR021W":null},"has_protein_features":false,"name":"DPC29","ortholog_annotations":[{"gene_uniquename":"YGR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03550","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR021W"}


id: YGR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W","secondary_identifier":"SGD:S000003254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR022C"}


id: YGR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MTL1","product":"Putative plasma membrane sensor; involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p; MTL1 has a paralog, MID2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR023W"}


id: YGR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04233":null,"YGR024C":null},"has_protein_features":false,"name":"THG1","ortholog_annotations":[{"gene_uniquename":"YGR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04233","reference_uniquename":"PMID:29761456"}],"product":"tRNAHis guanylyltransferase; adds a guanosine residue to the 5' end of tRNAH is after transcription and RNase P cleavage; can also catalyze reverse (3'-5') polymerization with certain substrates in a template-dependent reaction; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR024C"}


id: YGR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000003257","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR025W"}


id: YGR026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01460":null,"YGR026W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01460","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003258","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR026W"}


id: YGR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04672":null,"YGR027C":null},"has_protein_features":false,"name":"RPS25A","ortholog_annotations":[{"gene_uniquename":"YGR027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04672","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003259","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR027C"}


id: YGR028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04203":null,"YGR028W":null},"has_protein_features":false,"name":"MSP1","ortholog_annotations":[{"gene_uniquename":"YGR028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04203","reference_uniquename":"PMID:29761456"}],"product":"Highly-conserved N-terminally anchored AAA-ATPase; distributed in the mitochondrial outer membrane and peroxisomes; involved in mitochondrial protein sorting; functions as an extraction engine in local organelle surveillance to remove and initiate degradation of mistargeted proteins, ensuring fidelity of organelle-specific localization of tail-anchored proteins; contains an N-terminal transmembrane domain and C-terminal cytoplasmic ATPase domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003260","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR028W"}


id: YGR029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01647":null,"YGR029W":null},"has_protein_features":false,"name":"ERV1","ortholog_annotations":[{"gene_uniquename":"YGR029W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01647","reference_uniquename":"PMID:29761456"}],"product":"Flavin-linked sulfhydryl oxidase of the mitochondrial IMS; N-terminus is an intrinsically disordered domain that in the cytosol helps target Erv1p to mitochondria, and in the intermembrane space oxidizes Mia40p as part of a disulfide relay system that promotes intermembrane space retention of imported proteins; functional ortholog of human GFER (ALR); human GFER carrying N-terminal 21 amino acids of Erv1p functionally complements the lethality of the erv1 null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003261","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR029W"}


id: YGR030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01369":null,"SJAG_06613":null,"YGR030C":null},"has_protein_features":false,"name":"POP6","ortholog_annotations":[{"gene_uniquename":"YGR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01369","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06613","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop7p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003262","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR030C"}


id: YGR031C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NAG1","product":"Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; gene is nested within and antisense to IMO32","secondary_identifier":"SGD:S000028636","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR031C-A"}


id: YGR031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00734":null,"YGR031W":null},"has_protein_features":false,"name":"IMO32","ortholog_annotations":[{"gene_uniquename":"YGR031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00734","reference_uniquename":"PMID:29761456"}],"product":"Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003263","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR031W"}


id: YGR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01288":null,"SJAG_02222":null,"SJAG_03587":null,"SJAG_05285":null,"YGR032W":null},"has_protein_features":false,"name":"GSC2","ortholog_annotations":[{"gene_uniquename":"YGR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01288","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02222","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03587","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05285","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of 1,3-beta-glucan synthase; involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; GSC2 has a paralog, FKS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003264","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR032W"}


id: YGR033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01442":null,"YGR033C":null},"has_protein_features":false,"name":"TIM21","ortholog_annotations":[{"gene_uniquename":"YGR033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01442","reference_uniquename":"PMID:29761456"}],"product":"Nonessential component of the TIM23 complex; interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate the Translocase of the Inner Mitochondrial membrane (TIM23 complex) activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003265","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR033C"}


id: YGR034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00921":null,"YGR034W":null},"has_protein_features":false,"name":"RPL26B","ortholog_annotations":[{"gene_uniquename":"YGR034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00921","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003266","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR034W"}


id: YGR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YGR035C has a paralog, YLR346C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003267","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR035C"}


id: YGR035W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028827","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR035W-A"}


id: YGR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02056":null,"YGR036C":null},"has_protein_features":false,"name":"CAX4","ortholog_annotations":[{"gene_uniquename":"YGR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02056","reference_uniquename":"PMID:29761456"}],"product":"Dolichyl pyrophosphate (Dol-P-P) phosphatase; cleaves the anhydride linkage in Dol-P-P; involved in  synthesis of Dol-P-P-linked oligosaccharide intermediate required for protein N-glycosylation; has a luminally oriented active site in the ER; mutation affects vesicular transport, membrane and cell wall biogenesis and lipid homeostasis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003268","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR036C"}


id: YGR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01458":null,"YGR037C":null},"has_protein_features":false,"name":"ACB1","ortholog_annotations":[{"gene_uniquename":"YGR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01458","reference_uniquename":"PMID:29761456"}],"product":"Acyl-CoA-binding protein; transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003269","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR037C"}


id: YGR038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04550":null,"YGR038W":null},"has_protein_features":false,"name":"ORM1","ortholog_annotations":[{"gene_uniquename":"YGR038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04550","reference_uniquename":"PMID:29761456"}],"product":"Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; ORM1 has a paralog, ORM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003270","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR038W"}


id: YGR039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YGR039W is not an essential gene","secondary_identifier":"SGD:S000003271","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR039W"}


id: YGR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02923":null,"YGR040W":null},"has_protein_features":false,"name":"KSS1","ortholog_annotations":[{"gene_uniquename":"YGR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02923","reference_uniquename":"PMID:29761456"}],"product":"Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate Bni4p; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003272","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR040W"}


id: YGR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BUD9","product":"Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole; BUD9 has a paralog, BUD8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003273","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR041W"}


id: YGR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02616":null,"YGR042W":null},"has_protein_features":false,"name":"MTE1","ortholog_annotations":[{"gene_uniquename":"YGR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02616","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003274","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR042W"}


id: YGR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04263":null,"YGR043C":null},"has_protein_features":false,"name":"NQM1","ortholog_annotations":[{"gene_uniquename":"YGR043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04263","reference_uniquename":"PMID:29761456"}],"product":"Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; NQM1 has a paralog, TAL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003275","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR043C"}


id: YGR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RME1","product":"Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000003276","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR044C"}


id: YGR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000003277","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR045C"}


id: YGR046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03563":null,"YGR046W":null},"has_protein_features":false,"name":"TAM41","ortholog_annotations":[{"gene_uniquename":"YGR046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03563","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase); required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003278","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR046W"}


id: YGR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01827":null,"YGR047C":null},"has_protein_features":false,"name":"TFC4","ortholog_annotations":[{"gene_uniquename":"YGR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01827","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003279","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR047C"}


id: YGR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04384":null,"YGR048W":null},"has_protein_features":false,"name":"UFD1","ortholog_annotations":[{"gene_uniquename":"YGR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04384","reference_uniquename":"PMID:29761456"}],"product":"Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transcription factors by regulated Ub/proteasome-dependent processing (RUP)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003280","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR048W"}


id: YGR049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SCM4","product":"Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation; SCM4 has a paralog, ATG33, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003281","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR049W"}


id: YGR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data","secondary_identifier":"SGD:S000003282","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR050C"}


id: YGR051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene","secondary_identifier":"SGD:S000003283","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR051C"}


id: YGR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03529":null,"YGR052W":null},"has_protein_features":false,"name":"FMP48","ortholog_annotations":[{"gene_uniquename":"YGR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03529","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000003284","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR052W"}


id: YGR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06256":null,"YGR053C":null},"has_protein_features":false,"name":"MCO32","ortholog_annotations":[{"gene_uniquename":"YGR053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06256","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003285","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR053C"}


id: YGR054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03788":null,"YGR054W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03788","reference_uniquename":"PMID:29761456"}],"product":"Eukaryotic initiation factor eIF2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003286","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR054W"}


id: YGR055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MUP1","product":"High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; involved in both methionine and cysteine uptake; subject to transport-activity dependent, methionine-induced endocytosis, vacuolar delivery and degradation; starvation-induced endocytosis is transport-activity independent","secondary_identifier":"SGD:S000003287","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR055W"}


id: YGR056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03787":null,"YGR056W":null},"has_protein_features":false,"name":"RSC1","ortholog_annotations":[{"gene_uniquename":"YGR056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03787","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook; RSC1 has a paralog, RSC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003288","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR056W"}


id: YGR057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02231":null,"YGR057C":null},"has_protein_features":false,"name":"LST7","ortholog_annotations":[{"gene_uniquename":"YGR057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02231","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino acid stimulation; required for activation of TORC1 in response to amino acid stimulation; recruited to the vacuolar membrane during amino acid starvation and released from the membrane by TORC1; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003289","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR057C"}


id: YGR058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEF1","product":"Penta-EF-hand protein; required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly","secondary_identifier":"SGD:S000003290","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR058W"}


id: YGR059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPR3","product":"Sporulation-specific homolog of the CDC3/10/11/12 family of genes; septin protein involved in sporulation; regulated by ABFI; the yeast CDC3/10/11/12 family is a family of bud neck microfilament genes","secondary_identifier":"SGD:S000003291","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR059W"}


id: YGR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03018":null,"YGR060W":null},"has_protein_features":false,"name":"ERG25","ortholog_annotations":[{"gene_uniquename":"YGR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03018","reference_uniquename":"PMID:29761456"}],"product":"C-4 methyl sterol oxidase; catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol; human MSMO1 functionally complements the growth defect caused by repression of ERG25 expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003292","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR060W"}


id: YGR061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03355":null,"YGR061C":null},"has_protein_features":false,"name":"ADE6","ortholog_annotations":[{"gene_uniquename":"YGR061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03355","reference_uniquename":"PMID:29761456"}],"product":"Formylglycinamidine-ribonucleotide (FGAM)-synthetase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003293","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR061C"}


id: YGR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05302":null,"YGR062C":null},"has_protein_features":false,"name":"COX18","ortholog_annotations":[{"gene_uniquename":"YGR062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05302","reference_uniquename":"PMID:29761456"}],"product":"Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC; respiratory defect of the null mutant is functionally complemented by human COX18 carrying the N-terminal 54 amino acids of S. cerevisiae Cox18p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003294","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR062C"}


id: YGR063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00483":null,"YGR063C":null},"has_protein_features":false,"name":"SPT4","ortholog_annotations":[{"gene_uniquename":"YGR063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00483","reference_uniquename":"PMID:29761456"}],"product":"Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and along with RNAP I and II has multiple roles regulating transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; localizes to kinetochores and heterochromatin, influencing chromosomal dynamics and silencing; required for transcription through long trinucleotide repeats in ORFs and non-protein coding regions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003295","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR063C"}


id: YGR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C","secondary_identifier":"SGD:S000003296","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR064W"}


id: YGR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02779":null,"SJAG_02780":null,"YGR065C":null},"has_protein_features":false,"name":"VHT1","ortholog_annotations":[{"gene_uniquename":"YGR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02779","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02780","reference_uniquename":"PMID:29761456"}],"product":"High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003297","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR065C"}


id: YGR066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03385":null,"YGR066C":null},"has_protein_features":false,"name":"GID10","ortholog_annotations":[{"gene_uniquename":"YGR066C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03385","reference_uniquename":"PMID:29761456"}],"product":"Recognition component (N-recognin) of the Pro/N-degron pathway; recognizes and targets for degradation proteins with N-terminal degradation signals; expressed only under starvation or osmotic stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003298","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR066C"}


id: YGR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p","secondary_identifier":"SGD:S000003299","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR067C"}


id: YGR068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00803":null,"SJAG_01686":null,"YGR068C":null},"has_protein_features":false,"name":"ART5","ortholog_annotations":[{"gene_uniquename":"YGR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00803","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01686","reference_uniquename":"PMID:26896847"}],"product":"Protein proposed to regulate endocytosis of plasma membrane proteins; regulates by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane; SWAT-GFP and mCherry fusion proteins localize to the cytosol","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000003300","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR068C"}


id: YGR068W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with the uncharacterized ORF YGR068C","secondary_identifier":"SGD:S000028637","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR068W-A"}


id: YGR069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003301","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR069W"}


id: YGR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03705":null,"SJAG_04771":null,"YGR070W":null},"has_protein_features":false,"name":"ROM1","ortholog_annotations":[{"gene_uniquename":"YGR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03705","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04771","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP; ROM1 has a paralog, ROM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003302","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR070W"}


id: YGR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ENV11","product":"Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; ENV11 has a paralog, VID22, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003303","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR071C"}


id: YGR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04056":null,"YGR072W":null},"has_protein_features":false,"name":"UPF3","ortholog_annotations":[{"gene_uniquename":"YGR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04056","reference_uniquename":"PMID:29761456"}],"product":"Component of the nonsense-mediated mRNA decay (NMD) pathway; along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003304","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR072W"}


id: YGR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; extensively overlaps essential SMD1 gene encoding a U6 snRNP protein","secondary_identifier":"SGD:S000003305","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR073C"}


id: YGR074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00147":null,"YGR074W":null},"has_protein_features":false,"name":"SMD1","ortholog_annotations":[{"gene_uniquename":"YGR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00147","reference_uniquename":"PMID:29761456"}],"product":"Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; relocalizes to the cytosol in response to hypoxia; homolog of human Sm D1; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003306","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR074W"}


id: YGR075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01308":null,"YGR075C":null},"has_protein_features":false,"name":"PRP38","ortholog_annotations":[{"gene_uniquename":"YGR075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01308","reference_uniquename":"PMID:29761456"}],"product":"Unique component of the U4/U6.U5 tri-snRNP particle; tri-snRNP is required for conformational changes which result in the catalytic activation of the spliceosome; dispensable for spliceosome assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003307","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR075C"}


id: YGR076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02762":null,"YGR076C":null},"has_protein_features":false,"name":"MRPL25","ortholog_annotations":[{"gene_uniquename":"YGR076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02762","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003308","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR076C"}


id: YGR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05315":null,"YGR077C":null},"has_protein_features":false,"name":"PEX8","ortholog_annotations":[{"gene_uniquename":"YGR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05315","reference_uniquename":"PMID:29761456"}],"product":"Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003309","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR077C"}


id: YGR078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00505":null,"YGR078C":null},"has_protein_features":false,"name":"PAC10","ortholog_annotations":[{"gene_uniquename":"YGR078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00505","reference_uniquename":"PMID:29761456"}],"product":"Part of the heteromeric co-chaperone GimC/prefoldin complex; complex promotes efficient protein folding","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003310","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR078C"}


id: YGR079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; YGR079W is not an essential gene","secondary_identifier":"SGD:S000003311","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR079W"}


id: YGR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01993":null,"YGR080W":null},"has_protein_features":false,"name":"TWF1","ortholog_annotations":[{"gene_uniquename":"YGR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01993","reference_uniquename":"PMID:29761456"}],"product":"Twinfilin; highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton; coordinates actin filament severing and monomer sequestering at sites of rapid actin turnover; composed of two cofilin-like regions, stimulates actin depolymerization as does the mouse homolog, mTwf1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003312","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR080W"}


id: YGR081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04339":null,"YGR081C":null},"has_protein_features":false,"name":"SLX9","ortholog_annotations":[{"gene_uniquename":"YGR081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04339","reference_uniquename":"PMID:29761456"}],"product":"Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; binds G-quadruplex (G4) structures in DNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003313","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR081C"}


id: YGR082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03358":null,"YGR082W":null},"has_protein_features":false,"name":"TOM20","ortholog_annotations":[{"gene_uniquename":"YGR082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03358","reference_uniquename":"PMID:29761456"}],"product":"Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003314","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR082W"}


id: YGR083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02307":null,"YGR083C":null},"has_protein_features":false,"name":"GCD2","ortholog_annotations":[{"gene_uniquename":"YGR083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02307","reference_uniquename":"PMID:29761456"}],"product":"Delta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003315","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR083C"}


id: YGR084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MRP13","product":"Mitochondrial ribosomal protein of the small subunit","secondary_identifier":"SGD:S000003316","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR084C"}


id: YGR085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00465":null,"SJAG_02280":null,"YGR085C":null},"has_protein_features":false,"name":"RPL11B","ortholog_annotations":[{"gene_uniquename":"YGR085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00465","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02280","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003317","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR085C"}


id: YGR086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02626":null,"SJAG_02707":null,"YGR086C":null},"has_protein_features":false,"name":"PIL1","ortholog_annotations":[{"gene_uniquename":"YGR086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02626","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02707","reference_uniquename":"PMID:29761456"}],"product":"Eisosome core component; eisosomes are large immobile cell cortex structures associated with endocytosis; detected in phosphorylated state in mitochondria; phosphorylated on Thr233 upon Pkc1p hyperactivation in a Slt2p MAPK-dependent fashion; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; member of BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003318","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR086C"}


id: YGR087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02734":null,"SJAG_03743":null,"SJAG_04842":null,"YGR087C":null},"has_protein_features":false,"name":"PDC6","ortholog_annotations":[{"gene_uniquename":"YGR087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02734","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03743","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04842","reference_uniquename":"PMID:29761456"}],"product":"Minor isoform of pyruvate decarboxylase; decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003319","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR087C"}


id: YGR088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04823":null,"YGR088W":null},"has_protein_features":false,"name":"CTT1","ortholog_annotations":[{"gene_uniquename":"YGR088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04823","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003320","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR088W"}


id: YGR089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NNF2","product":"Protein that exhibits physical and genetic interactions with Rpb8p; Rpb8p is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation","secondary_identifier":"SGD:S000003321","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR089W"}


id: YGR090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03156":null,"YGR090W":null},"has_protein_features":false,"name":"UTP22","ortholog_annotations":[{"gene_uniquename":"YGR090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03156","reference_uniquename":"PMID:29761456"}],"product":"Component of the small-subunit processome; required for nuclear export of tRNAs; forms a complex with Rrp7p; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003322","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR090W"}


id: YGR091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04529":null,"YGR091W":null},"has_protein_features":false,"name":"PRP31","ortholog_annotations":[{"gene_uniquename":"YGR091W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04529","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor; component of the U4/U6-U5 snRNP complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003323","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR091W"}


id: YGR092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02736":null,"SJAG_04597":null,"YGR092W":null},"has_protein_features":false,"name":"DBF2","ortholog_annotations":[{"gene_uniquename":"YGR092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02736","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04597","reference_uniquename":"PMID:29761456"}],"product":"Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis; DBF2 has a paralog, DBF20, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003324","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR092W"}


id: YGR093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05212":null,"YGR093W":null},"has_protein_features":false,"name":"DRN1","ortholog_annotations":[{"gene_uniquename":"YGR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05212","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor that modulates turnover of branched RNAs by Dbr1p; interacts with spliceosomal components and branched RNA splicing products; enhances Dbr1p debranching in vitro; conserved protein with domain organization identical from yeast to human; N-terminal homology to Dbr1p N-terminus, but Dbr1p catalytic residues not conserved; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003325","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR093W"}


id: YGR094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00443":null,"SJAG_02428":null,"YGR094W":null},"has_protein_features":false,"name":"VAS1","ortholog_annotations":[{"gene_uniquename":"YGR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00443","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02428","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial and cytoplasmic valyl-tRNA synthetase; human homolog VARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003326","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR094W"}


id: YGR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04153":null,"YGR095C":null},"has_protein_features":false,"name":"RRP46","ortholog_annotations":[{"gene_uniquename":"YGR095C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04153","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003327","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR095C"}


id: YGR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00835":null,"YGR096W":null},"has_protein_features":false,"name":"TPC1","ortholog_annotations":[{"gene_uniquename":"YGR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00835","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial membrane transporter; mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003328","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR096W"}


id: YGR097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ASK10","product":"Regulator of the Fps1p glycerol channel; under nonstress conditions, binds to Fps1p to positively regulate glycerol transport; under osmotic stress, multiple phosphorylation by Hog1p causes Ask10p to dissociate from Fps1p; forms homodimers and heterodimerizes with paralog Rgc1p; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; associates with RNA polymerase II holoenzyme","secondary_identifier":"SGD:S000003329","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR097W"}


id: YGR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02542":null,"YGR098C":null},"has_protein_features":false,"name":"ESP1","ortholog_annotations":[{"gene_uniquename":"YGR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02542","reference_uniquename":"PMID:29761456"}],"product":"Separase/separin, a caspase-like cysteine protease; cleaves Mcd1p/Scc1p, a mitotic cohesin complex subunit, resulting in the dissociation of cohesin from chromatin and sister chromatid separation; cleaves meiotic-cohesin subunit Rec8p along chromosome arms in meiosis I and at centromeric sites during meiosis II; inhibits PP2A-Cdc55p to promote mitotic exit; inhibited by Pds1p (securin); relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003330","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR098C"}


id: YGR099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00112":null,"YGR099W":null},"has_protein_features":false,"name":"TEL2","ortholog_annotations":[{"gene_uniquename":"YGR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00112","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003331","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR099W"}


id: YGR100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00864":null,"SJAG_04013":null,"YGR100W":null},"has_protein_features":false,"name":"MDR1","ortholog_annotations":[{"gene_uniquename":"YGR100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00864","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04013","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003332","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR100W"}


id: YGR101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03121":null,"YGR101W":null},"has_protein_features":false,"name":"PCP1","ortholog_annotations":[{"gene_uniquename":"YGR101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03121","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial serine protease; required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003333","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR101W"}


id: YGR102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05560":null,"YGR102C":null},"has_protein_features":false,"name":"GTF1","ortholog_annotations":[{"gene_uniquename":"YGR102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05560","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003334","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR102C"}


id: YGR103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00882":null,"YGR103W":null},"has_protein_features":false,"name":"NOP7","ortholog_annotations":[{"gene_uniquename":"YGR103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00882","reference_uniquename":"PMID:29761456"}],"product":"Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G<sub>0</sub> and the initiation of cell proliferation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003335","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR103W"}


id: YGR104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04820":null,"YGR104C":null},"has_protein_features":false,"name":"SRB5","ortholog_annotations":[{"gene_uniquename":"YGR104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04820","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003336","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR104C"}


id: YGR105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01939":null,"YGR105W":null},"has_protein_features":false,"name":"VMA21","ortholog_annotations":[{"gene_uniquename":"YGR105W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01939","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; diverged ortholog of human XMEA (X-linked Myopathy with Excessive Autophagy); functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003337","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR105W"}


id: YGR106C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00771":null,"YGR106C":null},"has_protein_features":false,"name":"VOA1","ortholog_annotations":[{"gene_uniquename":"YGR106C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00771","reference_uniquename":"PMID:29761456"}],"product":"ER protein that functions in assembly of the V0 sector of V-ATPase; functions with other assembly factors; null mutation enhances the vacuolar ATPase (V-ATPase) deficiency of a vma21 mutant impaired in endoplasmic reticulum (ER) retrieval","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003338","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR106C"}


id: YGR107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003339","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR107W"}


id: YGR108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01401":null,"SJAG_04140":null,"YGR108W":null},"has_protein_features":false,"name":"CLB1","ortholog_annotations":[{"gene_uniquename":"YGR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01401","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04140","reference_uniquename":"PMID:29761456"}],"product":"B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB1 has a paralog, CLB2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003340","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR108W"}


id: YGR109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03525":null,"YGR109C":null},"has_protein_features":false,"name":"CLB6","ortholog_annotations":[{"gene_uniquename":"YGR109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03525","reference_uniquename":"PMID:26896847"}],"product":"B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1; CLB6 has a paralog, CLB5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000003341","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR109C"}


id: YGR110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04323":null,"YGR110W":null},"has_protein_features":false,"name":"CLD1","ortholog_annotations":[{"gene_uniquename":"YGR110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04323","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003342","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR110W"}


id: YGR111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","secondary_identifier":"SGD:S000003343","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR111W"}


id: YGR112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03046":null,"YGR112W":null},"has_protein_features":false,"name":"SHY1","ortholog_annotations":[{"gene_uniquename":"YGR112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03046","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein required for complex IV assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome; complex IV is also known as cytochrome c oxidase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003344","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR112W"}


id: YGR113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01224":null,"YGR113W":null},"has_protein_features":false,"name":"DAM1","ortholog_annotations":[{"gene_uniquename":"YGR113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01224","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Duo1p and Pse1p to connect the DASH complex with the microtubules (MT); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003345","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR113W"}


id: YGR114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6","secondary_identifier":"SGD:S000003346","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR114C"}


id: YGR115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C","secondary_identifier":"SGD:S000003347","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR115C"}


id: YGR116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04670":null,"YGR116W":null},"has_protein_features":false,"name":"SPT6","ortholog_annotations":[{"gene_uniquename":"YGR116W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04670","reference_uniquename":"PMID:29761456"}],"product":"Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for fidelity of promoter selection through maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within coding regions; required for H3K36 trimethylation but not dimethylation by Set2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003348","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR116W"}


id: YGR117C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000003349","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR117C"}


id: YGR118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01632":null,"SJAG_02682":null,"SJAG_03568":null,"YGR118W":null},"has_protein_features":false,"name":"RPS23A","ortholog_annotations":[{"gene_uniquename":"YGR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01632","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02682","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03568","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003350","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR118W"}


id: YGR119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02210":null,"YGR119C":null},"has_protein_features":false,"name":"NUP57","ortholog_annotations":[{"gene_uniquename":"YGR119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02210","reference_uniquename":"PMID:29761456"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003351","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR119C"}


id: YGR120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00578":null,"YGR120C":null},"has_protein_features":false,"name":"COG2","ortholog_annotations":[{"gene_uniquename":"YGR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00578","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; the components of the Golgi complex are Gog1p through Cog8p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003352","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR120C"}


id: YGR121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04136":null,"SJAG_04731":null,"YGR121C":null},"has_protein_features":false,"name":"MEP1","ortholog_annotations":[{"gene_uniquename":"YGR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04136","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04731","reference_uniquename":"PMID:29761456"}],"product":"Ammonium permease; belongs to Mep-Amt-Rh family of well-conserved ammonium (NH4+) transporters that includes the human Rh factors; expression is under the nitrogen catabolite repression regulation; activity regulated by TORC1 effectors, Npr1p and Par32p; human homolog RHCG complements yeast null mutant; mutations in human homolog RHCG implicated in metabolic acidosis; MEP1 has a paralog, MEP3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003353","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR121C"}


id: YGR121W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028550","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR121W-A"}


id: YGR122C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; similar to YLR334C and YOL106W","secondary_identifier":"SGD:S000007240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR122C-A"}


id: YGR122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress","secondary_identifier":"SGD:S000003354","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR122W"}


id: YGR123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02854":null,"YGR123C":null},"has_protein_features":false,"name":"PPT1","ortholog_annotations":[{"gene_uniquename":"YGR123C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02854","reference_uniquename":"PMID:29761456"}],"product":"Protein serine/threonine phosphatase; regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003355","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR123C"}


id: YGR124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04549":null,"YGR124W":null},"has_protein_features":false,"name":"ASN2","ortholog_annotations":[{"gene_uniquename":"YGR124W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04549","reference_uniquename":"PMID:29761456"}],"product":"Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003356","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR124W"}


id: YGR125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00877":null,"YGR125W":null},"has_protein_features":false,"name":"VSB1","ortholog_annotations":[{"gene_uniquename":"YGR125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00877","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane protein required for uptake and storage of arginine in nitrogen-replete cells; nitrogen starvation appears to inhibit Vsb1-dependent activity, resulting in mobilization of stored vacuolar arginine to the cytosol; arginine uptake appears to be driven by a V-ATPase mediated H+ gradient; member of the APC (amino acid-polyamine-organocation) transporter superfamily","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003357","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR125W"}


id: YGR126W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000003358","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR126W"}


id: YGR127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response","secondary_identifier":"SGD:S000003359","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR127W"}


id: YGR128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03341":null,"YGR128C":null},"has_protein_features":false,"name":"UTP8","ortholog_annotations":[{"gene_uniquename":"YGR128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03341","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003360","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR128C"}


id: YGR129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02844":null,"YGR129W":null},"has_protein_features":false,"name":"SYF2","ortholog_annotations":[{"gene_uniquename":"YGR129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02844","reference_uniquename":"PMID:29761456"}],"product":"Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; relocalizes to the cytosol in response to hypoxia; isy1 syf2 cells have defective spindles activiating cell cycle arrest","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003361","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR129W"}


id: YGR130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)","secondary_identifier":"SGD:S000003362","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR130C"}


id: YGR131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02338":null,"YGR131W":null},"has_protein_features":false,"name":"FHN1","ortholog_annotations":[{"gene_uniquename":"YGR131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02338","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain; FHN1 has a paralog, NCE102, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003363","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR131W"}


id: YGR132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00079":null,"YGR132C":null},"has_protein_features":false,"name":"PHB1","ortholog_annotations":[{"gene_uniquename":"YGR132C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00079","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003364","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR132C"}


id: YGR133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04857":null,"YGR133W":null},"has_protein_features":false,"name":"PEX4","ortholog_annotations":[{"gene_uniquename":"YGR133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04857","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal ubiquitin conjugating enzyme; required for peroxisomal matrix protein import and peroxisome biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003365","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR133W"}


id: YGR134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CAF130","product":"Subunit of the CCR4-NOT transcriptional regulatory complex; CCR4-NOT complex is evolutionarily-conserved and involved in controlling mRNA initiation, elongation, and degradation","secondary_identifier":"SGD:S000003366","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR134W"}


id: YGR135W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00808":null,"YGR135W":null},"has_protein_features":false,"name":"PRE9","ortholog_annotations":[{"gene_uniquename":"YGR135W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00808","reference_uniquename":"PMID:29761456"}],"product":"Alpha 3 subunit of the 20S proteasome; the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003367","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR135W"}


id: YGR136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04554":null,"YGR136W":null},"has_protein_features":false,"name":"LSB1","ortholog_annotations":[{"gene_uniquename":"YGR136W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04554","reference_uniquename":"PMID:29761456"}],"product":"Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003368","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR136W"}


id: YGR137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003369","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR137W"}


id: YGR138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02344":null,"YGR138C":null},"has_protein_features":false,"name":"TPO2","ortholog_annotations":[{"gene_uniquename":"YGR138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02344","reference_uniquename":"PMID:29761456"}],"product":"Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003370","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR138C"}


id: YGR139W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003371","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR139W"}


id: YGR140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CBF2","product":"Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; sumoylated in an Mms21p-dependent manner; relative distribution to the spindle pole body decreases upon DNA replication stress","secondary_identifier":"SGD:S000003372","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR140W"}


id: YGR141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"VPS62","product":"Vacuolar protein sorting (VPS) protein; required for cytoplasm to vacuole targeting of proteins; VPS62 has a paralog, TDA6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003373","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR141W"}


id: YGR142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BTN2","product":"v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; contributes to prion curing; preferentially expressed after severe ethanol stress","secondary_identifier":"SGD:S000003374","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR142W"}


id: YGR143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02446":null,"SJAG_02590":null,"SJAG_04690":null,"YGR143W":null},"has_protein_features":false,"name":"SKN1","ortholog_annotations":[{"gene_uniquename":"YGR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02446","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02590","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04690","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in sphingolipid biosynthesis; type II membrane protein; SKN1 has a paralog, KRE6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003375","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR143W"}


id: YGR144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00827":null,"YGR144W":null},"has_protein_features":false,"name":"THI4","ortholog_annotations":[{"gene_uniquename":"YGR144W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00827","reference_uniquename":"PMID:29761456"}],"product":"Thiazole synthase; abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003376","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR144W"}


id: YGR145W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04033":null,"YGR145W":null},"has_protein_features":false,"name":"ENP2","ortholog_annotations":[{"gene_uniquename":"YGR145W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04033","reference_uniquename":"PMID:29761456"}],"product":"Component of the SSU; required for pre-18S rRNA processing, biogenesis of the small ribosomal subunit; interacts with U3 snoRNA, Mpp10p and Bfr2p; contains WD repeats, and has homology to Spb1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003377","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR145W"}


id: YGR146C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03974":null,"YGR146C":null},"has_protein_features":false,"name":"ECL1","ortholog_annotations":[{"gene_uniquename":"YGR146C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03974","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR146C"}


id: YGR146C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR146C-A"}


id: YGR147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_07016":null,"YGR147C":null},"has_protein_features":false,"name":"NAT2","ortholog_annotations":[{"gene_uniquename":"YGR147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07016","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; has an apparent role in acetylation of N-terminal methionine residues","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR147C"}


id: YGR148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02243":null,"SJAG_03922":null,"YGR148C":null},"has_protein_features":false,"name":"RPL24B","ortholog_annotations":[{"gene_uniquename":"YGR148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02243","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03922","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR148C"}


id: YGR149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03154":null,"YGR149W":null},"has_protein_features":false,"name":"GPC1","ortholog_annotations":[{"gene_uniquename":"YGR149W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03154","reference_uniquename":"PMID:29761456"}],"product":"Glycerophosphocholine acyltransferase (GPCAT); involved in in phosphatidylcholine (PC) synthesis; uses acyl-CoA to acylate glycero-3-phosphocholine to yield lyso-PC; also catalyzes acylation of glycerophosphoethanolamine with acyl-CoA; predicted to be an integral membrane protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR149W"}


id: YGR150C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02217":null,"YGR150C":null},"has_protein_features":false,"name":"CCM1","ortholog_annotations":[{"gene_uniquename":"YGR150C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02217","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial 15S rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; has separable roles in stabilizing mitochondrial 15S rRNA and in maturation of the COB and COX1 mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR150C"}


id: YGR151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000003383","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR151C"}


id: YGR152C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RSR1","product":"Ras-type GTPase; required for bud site selection during both axial and bipolar budding, for morphological changes in response to mating pheromone, and for efficient cell fusion; recruits Cdc24p to the incipient bud site, activating its guanyl-nucleotide exchange factor activity and the Rho-like GTPase, Cdc42p; localizes to the plasma membrane, the incipient bud site, polarized growth sites, the cell division site and the vacuole membrane; Ras superfamily member similar to mammalian Rap GTPases","secondary_identifier":"SGD:S000003384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR152C"}


id: YGR153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000003385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR153W"}


id: YGR154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GTO1","product":"Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization","secondary_identifier":"SGD:S000003386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR154C"}


id: YGR155W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CYS4","product":"Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria; human CBS can complement yeast null mutant","secondary_identifier":"SGD:S000003387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR155W"}


id: YGR156W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PTI1","product":"Essential component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; relocalizes to the cytosol in response to hypoxia; similar to mammalian Cleavage-Stimulation Factor CstF-64","secondary_identifier":"SGD:S000003388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR156W"}


id: YGR157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00825":null,"YGR157W":null},"has_protein_features":false,"name":"CHO2","ortholog_annotations":[{"gene_uniquename":"YGR157W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00825","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylethanolamine methyltransferase (PEMT); catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR157W"}


id: YGR158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00854":null,"YGR158C":null},"has_protein_features":false,"name":"MTR3","ortholog_annotations":[{"gene_uniquename":"YGR158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00854","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR158C"}


id: YGR159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00259":null,"YGR159C":null},"has_protein_features":false,"name":"NSR1","ortholog_annotations":[{"gene_uniquename":"YGR159C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00259","reference_uniquename":"PMID:29761456"}],"product":"Nucleolin, nucleolar protein that binds nuclear localization sequences; required for pre-rRNA processing and ribosome biogenesis; binds to single stranded telomeric DNA and mRNA; binds to G-quadruplex DNA; methylated by Hmt1p; interaction with Top1p and nucleolar localization are negatively regulated by polyphosphorylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR159C"}


id: YGR160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR160W"}


id: YGR161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RTS3","product":"Putative component of the protein phosphatase type 2A complex","secondary_identifier":"SGD:S000003393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR161C"}


id: YGR161W-C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species","secondary_identifier":"SGD:S000029726","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR161W-C"}


id: YGR162W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01954":null,"YGR162W":null},"has_protein_features":false,"name":"TIF4631","ortholog_annotations":[{"gene_uniquename":"YGR162W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01954","reference_uniquename":"PMID:29761456"}],"product":"Translation initiation factor eIF4G and scaffold protein; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E (Cdc33p) and eIF4A (Tif1p/Tif2p); stimulates the ATPase and helicase activities of eIF4A synergistically with eIF4G; required with eIF4E for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; association with Pab1p mediates poly(A) tail-stimulated translation; role in biogenesis of the 60S ribosomal subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003394","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR162W"}


id: YGR163W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03371":null,"YGR163W":null},"has_protein_features":false,"name":"GTR2","ortholog_annotations":[{"gene_uniquename":"YGR163W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03371","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex; subunit of Gtr1-Gtr2, a GTPase that activates TORC1 in response to amino acid stimulation; negatively regulates the GTPase cycle of Gtr1p, a Ran/TC4 homolog; subunit of EGO, a vacuolar/endosomal membrane complex that regulates exit from rapamycin-induced growth arrest and endosome to plasma membrane sorting of Gap1p; activates transcription when chromatin bound; activated by the Lst4p-Lst7p GAP complex; homolog of human RagC","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003395","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR163W"}


id: YGR164W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000003396","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR164W"}


id: YGR165W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02067":null,"YGR165W":null},"has_protein_features":false,"name":"MRPS35","ortholog_annotations":[{"gene_uniquename":"YGR165W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02067","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003397","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR165W"}


id: YGR166W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03663":null,"YGR166W":null},"has_protein_features":false,"name":"TRS65","ortholog_annotations":[{"gene_uniquename":"YGR166W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03663","reference_uniquename":"PMID:29761456"}],"product":"Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; role in cell wall beta-glucan biosynthesis and the stress response","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003398","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR166W"}


id: YGR167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04517":null,"YGR167W":null},"has_protein_features":false,"name":"CLC1","ortholog_annotations":[{"gene_uniquename":"YGR167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04517","reference_uniquename":"PMID:29761456"}],"product":"Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; regulates endocytic progression; thought to regulate clathrin function; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003399","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR167W"}


id: YGR168C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEX35","product":"Regulator of peroxisome abundance; peroxisomal membrane protein, remote homolog to several curvature-generating human proteins; functionally interacts with vesicle-budding-inducing ADP-ribosylation factor Arf1p","secondary_identifier":"SGD:S000003400","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR168C"}


id: YGR169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PUS6","product":"tRNA:pseudouridine synthase; catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability","secondary_identifier":"SGD:S000003401","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR169C"}


id: YGR169C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03924":null,"YGR169C-A":null},"has_protein_features":false,"name":"LSO2","ortholog_annotations":[{"gene_uniquename":"YGR169C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03924","reference_uniquename":"PMID:29761456"}],"product":"Ribosome-associated protein; required for global translational elongation after recovery from stationary phase due to starvation; crosslinks to the 25S rRNA near the A site that overlaps the GTPase activation center, and to tRNAs; possible role in the iron deprivation response; localizes to the nucleus and cytoplasm, with enhanced nuclear localization under iron-replete conditions; null mutant exhibits slow growth during iron deprivation; orthologous to human CCDC124","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR169C-A"}


id: YGR170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02902":null,"YGR170W":null},"has_protein_features":false,"name":"PSD2","ortholog_annotations":[{"gene_uniquename":"YGR170W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02902","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes; converts phosphatidylserine to phosphatidylethanolamine; controls vacuolar membrane phospholipid content by regulating phospholipids in compartments that will eventually give rise to the vacuole; loss of Psd2p causes a specific reduction in vacuolar membrane PE levels while total PE levels are not significantly affected","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003402","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR170W"}


id: YGR171C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_16456":null,"YGR171C":null},"has_protein_features":false,"name":"MSM1","ortholog_annotations":[{"gene_uniquename":"YGR171C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16456","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial methionyl-tRNA synthetase (MetRS); functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003403","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR171C"}


id: YGR172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03670":null,"YGR172C":null},"has_protein_features":false,"name":"YIP1","ortholog_annotations":[{"gene_uniquename":"YGR172C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03670","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein; required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; human homolog YIPF5 can complement yeast yip1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003404","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR172C"}


id: YGR173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02331":null,"YGR173W":null},"has_protein_features":false,"name":"RBG2","ortholog_annotations":[{"gene_uniquename":"YGR173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02331","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003405","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR173W"}


id: YGR174C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05305":null,"YGR174C":null},"has_protein_features":false,"name":"CBP4","ortholog_annotations":[{"gene_uniquename":"YGR174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05305","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003406","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR174C"}


id: YGR174W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; predicted to have a role in cell budding based on computational 'guilt by association' analysis","secondary_identifier":"SGD:S000028639","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR174W-A"}


id: YGR175C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00370":null,"YGR175C":null},"has_protein_features":false,"name":"ERG1","ortholog_annotations":[{"gene_uniquename":"YGR175C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00370","reference_uniquename":"PMID:29761456"}],"product":"Squalene epoxidase; catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine; human SQLE functionally complements the lethality of the erg1 null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003407","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR175C"}


id: YGR176W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003408","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR176W"}


id: YGR177C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATF2","product":"Alcohol acetyltransferase; may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking","secondary_identifier":"SGD:S000003409","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR177C"}


id: YGR178C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01317":null,"YGR178C":null},"has_protein_features":false,"name":"PBP1","ortholog_annotations":[{"gene_uniquename":"YGR178C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01317","reference_uniquename":"PMID:29761456"}],"product":"Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; regulates TORC1 signaling and autophagy; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; similar to human ataxin-2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003410","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR178C"}


id: YGR179C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01928":null,"YGR179C":null},"has_protein_features":false,"name":"OKP1","ortholog_annotations":[{"gene_uniquename":"YGR179C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01928","reference_uniquename":"PMID:29761456"}],"product":"Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003411","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR179C"}


id: YGR180C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00885":null,"YGR180C":null},"has_protein_features":false,"name":"RNR4","ortholog_annotations":[{"gene_uniquename":"YGR180C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00885","reference_uniquename":"PMID:29761456"}],"product":"Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress; RNR4 has a paralog, RNR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003412","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR180C"}


id: YGR181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01949":null,"YGR181W":null},"has_protein_features":false,"name":"TIM13","ortholog_annotations":[{"gene_uniquename":"YGR181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01949","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial intermembrane space protein; forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003413","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR181W"}


id: YGR182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W","secondary_identifier":"SGD:S000003414","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR182C"}


id: YGR183C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01763":null,"YGR183C":null},"has_protein_features":false,"name":"QCR9","ortholog_annotations":[{"gene_uniquename":"YGR183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01763","reference_uniquename":"PMID:29761456"}],"product":"Subunit 9 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003415","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR183C"}


id: YGR184C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01253":null,"SJAG_04619":null,"YGR184C":null},"has_protein_features":false,"name":"UBR1","ortholog_annotations":[{"gene_uniquename":"YGR184C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01253","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR184C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04619","reference_uniquename":"PMID:29761456"}],"product":"E3 Ub-ligase (N-recognin); recognizes and ubiquitinates N-end rule pathway substrates in complex with Rad6p; Roq1p-bound form accelerates degradation of misfolded and native ER membrane and cytosolic proteins as part of the stress-induced homeostatically regulated protein degradation (SHRED) pathway; role in ER-associated protein degradation; modifies Cup9p to regulate peptide transport; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003416","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR184C"}


id: YGR185C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00243":null,"YGR185C":null},"has_protein_features":false,"name":"TYS1","ortholog_annotations":[{"gene_uniquename":"YGR185C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00243","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; human ortholog YARS functionally complements the heat sensitivity of a ts allele; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003417","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR185C"}


id: YGR186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00095":null,"YGR186W":null},"has_protein_features":false,"name":"TFG1","ortholog_annotations":[{"gene_uniquename":"YGR186W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00095","reference_uniquename":"PMID:29761456"}],"product":"TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003418","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR186W"}


id: YGR187C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02014":null,"YGR187C":null},"has_protein_features":false,"name":"HGH1","ortholog_annotations":[{"gene_uniquename":"YGR187C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02014","reference_uniquename":"PMID:29761456"}],"product":"Chaperone protein for translation factor eEF2; involved in biogenesis of eukaryotic Elongation Factor 2 (Eft1p, Eft2p); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003419","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR187C"}


id: YGR188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01082":null,"SJAG_04699":null,"YGR188C":null},"has_protein_features":false,"name":"BUB1","ortholog_annotations":[{"gene_uniquename":"YGR188C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01082","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR188C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04699","reference_uniquename":"PMID:26896847"}],"product":"Protein kinase involved in the cell cycle checkpoint into anaphase; in complex with Mad1p and Bub3p, prevents progression into anaphase in presence of spindle damage; Cdc28p-mediated phosphorylation at Bub1p-T566 is important for degradation in anaphase and adaptation of checkpoint to prolonged mitotic arrest; associates with centromere DNA via Skp1p; involved in Sgo1p relocalization in response to sister kinetochore tension; paralog MAD3 arose from whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003420","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR188C"}


id: YGR189C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04327":null,"YGR189C":null},"has_protein_features":false,"name":"CRH1","ortholog_annotations":[{"gene_uniquename":"YGR189C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04327","reference_uniquename":"PMID:29761456"}],"product":"Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR189C"}


id: YGR190C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W","secondary_identifier":"SGD:S000003422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR190C"}


id: YGR191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YGR191W":null},"has_protein_features":false,"name":"HIP1","ortholog_annotations":[{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"High-affinity histidine permease; also involved in the transport of manganese ions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR191W"}


id: YGR192C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00027":null,"SJAG_02135":null,"SJAG_02945":null,"SJAG_03828":null,"SJAG_03903":null,"SJAG_06621":null,"SJAG_06622":null,"YGR192C":null},"has_protein_features":false,"name":"TDH3","ortholog_annotations":[{"gene_uniquename":"YGR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00027","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02135","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02945","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03828","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03903","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06621","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06622","reference_uniquename":"PMID:29761456"}],"product":"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bacteria; binds AU-rich RNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003424","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR192C"}


id: YGR193C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00866":null,"YGR193C":null},"has_protein_features":false,"name":"PDX1","ortholog_annotations":[{"gene_uniquename":"YGR193C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00866","reference_uniquename":"PMID:29761456"}],"product":"E3-binding protein of the mitochondrial pyruvate dehydrogenase complex; plays a structural role in the complex by binding and positioning dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide acetyltransferase (E2) core","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR193C"}


id: YGR194C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04276":null,"YGR194C":null},"has_protein_features":false,"name":"XKS1","ortholog_annotations":[{"gene_uniquename":"YGR194C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04276","reference_uniquename":"PMID:29761456"}],"product":"Xylulokinase; converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003426","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR194C"}


id: YGR195W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03179":null,"YGR195W":null},"has_protein_features":false,"name":"SKI6","ortholog_annotations":[{"gene_uniquename":"YGR195W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03179","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003427","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR195W"}


id: YGR196C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02223":null,"YGR196C":null},"has_protein_features":false,"name":"FYV8","ortholog_annotations":[{"gene_uniquename":"YGR196C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02223","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; required for survival upon exposure to K1 killer toxin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003428","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR196C"}


id: YGR197C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNG1","product":"Protein involved in resistance to nitrosoguanidine and 6-azauracil; expression is regulated by transcription factors involved in multidrug resistance; SNG1 has a paralog, YJR015W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR197C"}


id: YGR198W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00137":null,"SJAG_04053":null,"YGR198W":null},"has_protein_features":false,"name":"YPP1","ortholog_annotations":[{"gene_uniquename":"YGR198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00137","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04053","reference_uniquename":"PMID:26896847"}],"product":"Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4p; is required, along with Efr3p, for the assembly and recruitment of multiple copies of the kinase into phosphoinositide kinase (PIK) patches at the plasma membrane; positively regulates Stt4p; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003430","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR198W"}


id: YGR199W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04053":null,"YGR199W":null},"has_protein_features":false,"name":"PMT6","ortholog_annotations":[{"gene_uniquename":"YGR199W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04053","reference_uniquename":"PMID:29761456"}],"product":"Protein O-mannosyltransferase; transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR199W"}


id: YGR200C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04704":null,"YGR200C":null},"has_protein_features":false,"name":"ELP2","ortholog_annotations":[{"gene_uniquename":"YGR200C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04704","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Elongator complex; binds to microtubules via conserved alkaline residues; has two seven-bladed WD40 &#946; propellers; Elongator complex is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003432","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR200C"}


id: YGR201C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02017":null,"SJAG_03863":null,"YGR201C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR201C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02017","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR201C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03863","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003433","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR201C"}


id: YGR202C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00946":null,"YGR202C":null},"has_protein_features":false,"name":"PCT1","ortholog_annotations":[{"gene_uniquename":"YGR202C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00946","reference_uniquename":"PMID:29761456"}],"product":"Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; controls phosphatidylcholine homeostasis; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR202C"}


id: YGR203W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04166":null,"YGR203W":null},"has_protein_features":false,"name":"YCH1","ortholog_annotations":[{"gene_uniquename":"YGR203W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04166","reference_uniquename":"PMID:29761456"}],"product":"Phosphatase with sequence similarity to Mih1p; member of the Cdc25p subfamily of tyrosine phosphatases and Arr2p, an arsenate reductase, based on the presence of a rhodanese-homology domain; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR203W"}


id: YGR204C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028640","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR204C-A"}


id: YGR204W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00106":null,"SJAG_04156":null,"YGR204W":null},"has_protein_features":false,"name":"ADE3","ortholog_annotations":[{"gene_uniquename":"YGR204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00106","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04156","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic trifunctional enzyme; catalyzes sequential reactions 10-formyl-THF synthetase (EC 6.3.4.3), 5,10-methenyl-THF cyclohydrolase (EC 3.5.4.9), and 5,10-methylene-THF dehydrogenase (EC 1.5.1.5), to supply forms of activated one-carbon units required for biosynthesis of purines, histidine, methionine, pantothenic acid, the formyl group of mitochondrial fMet-tRNAfMet, and the methyl group of thymidylate; null mutation causes auxotrophy for adenine and histidine in rich medium","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003436","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR204W"}


id: YGR205W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03017":null,"YGR205W":null},"has_protein_features":false,"name":"TDA10","ortholog_annotations":[{"gene_uniquename":"YGR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03017","reference_uniquename":"PMID:29761456"}],"product":"ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003437","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR205W"}


id: YGR206W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MVB12","product":"ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers; the ESCRT-I core complex (Stp22p, Vps28p, Srn2p) is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin","secondary_identifier":"SGD:S000003438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR206W"}


id: YGR207C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CIR1","product":"Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response","secondary_identifier":"SGD:S000003439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR207C"}


id: YGR208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04449":null,"YGR208W":null},"has_protein_features":false,"name":"SER2","ortholog_annotations":[{"gene_uniquename":"YGR208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04449","reference_uniquename":"PMID:29761456"}],"product":"Phosphoserine phosphatase of the phosphoglycerate pathway; involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003440","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR208W"}


id: YGR209C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04953":null,"YGR209C":null},"has_protein_features":false,"name":"TRX2","ortholog_annotations":[{"gene_uniquename":"YGR209C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04953","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system that protects cells from oxidative and reductive stress; subunit of the LMA1 complex, with Pbi2p, that promotes vacuole inheritance; cofactor for Tsa1p; required for ER-Golgi transport; facilitates mitochondrial import of small Tims (Tim9p, Tim10p, Tim13p) by maintaining them in reduced form along with Trx1p; component of a signal transduction redox relay in a light sensing pathway; abundance increases under DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR209C"}


id: YGR210C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02604":null,"YGR210C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR210C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02604","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003442","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR210C"}


id: YGR211W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02461":null,"YGR211W":null},"has_protein_features":false,"name":"ZPR1","ortholog_annotations":[{"gene_uniquename":"YGR211W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02461","reference_uniquename":"PMID:29761456"}],"product":"Essential protein with two zinc fingers; present in nucleus of growing cells, relocates to cytoplasm in starved cells via a process mediated by Cpr1p; binds translation elongation factor eEF-1 (Tef1p); relative distribution to nucleus increases upon DNA replication stress; human ZPR1 gene can complement yeast by allowing growth during down-regulation of yeast zpr1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003443","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR211W"}


id: YGR212W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SLI1","product":"N-acetyltransferase; confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin","secondary_identifier":"SGD:S000003444","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR212W"}


id: YGR213C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00018":null,"SJAG_00587":null,"SJAG_00589":null,"SJAG_01095":null,"SJAG_02114":null,"SJAG_02132":null,"SJAG_02581":null,"SJAG_02943":null,"SJAG_02957":null,"YGR213C":null},"has_protein_features":false,"name":"RTA1","ortholog_annotations":[{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00018","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00587","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00589","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01095","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02114","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02132","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02581","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02943","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02957","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein; RTA1 has a paralog, YLR046C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003445","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR213C"}


id: YGR214W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02184":null,"SJAG_02479":null,"SJAG_02803":null,"YGR214W":null},"has_protein_features":false,"name":"RPS0A","ortholog_annotations":[{"gene_uniquename":"YGR214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02184","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02479","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02803","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003446","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR214W"}


id: YGR215W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03065":null,"YGR215W":null},"has_protein_features":false,"name":"RSM27","ortholog_annotations":[{"gene_uniquename":"YGR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03065","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003447","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR215W"}


id: YGR216C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03066":null,"YGR216C":null},"has_protein_features":false,"name":"GPI1","ortholog_annotations":[{"gene_uniquename":"YGR216C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03066","reference_uniquename":"PMID:29761456"}],"product":"Membrane protein involved in the synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1 are functional homologs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003448","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR216C"}


id: YGR217W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05229":null,"YGR217W":null},"has_protein_features":false,"name":"CCH1","ortholog_annotations":[{"gene_uniquename":"YGR217W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05229","reference_uniquename":"PMID:29761456"}],"product":"Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and partially co-localizes with Mid1p; however, evidence suggests CCH1 is not required for Mid1p function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003449","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR217W"}


id: YGR218W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01358":null,"YGR218W":null},"has_protein_features":false,"name":"CRM1","ortholog_annotations":[{"gene_uniquename":"YGR218W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01358","reference_uniquename":"PMID:29761456"}],"product":"Nuclear export factor, exportin; major karyopherin involved in export of proteins, RNAs, and ribosomal subunits from the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003450","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR218W"}


id: YGR219W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C","secondary_identifier":"SGD:S000003451","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR219W"}


id: YGR220C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01413":null,"YGR220C":null},"has_protein_features":false,"name":"MRPL9","ortholog_annotations":[{"gene_uniquename":"YGR220C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01413","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003452","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR220C"}


id: YGR221C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TOS2","product":"Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p; TOS2 has a paralog, SKG6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003453","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR221C"}


id: YGR222W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PET54","product":"Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing; also stimulates efficient synthesis of Cox1p","secondary_identifier":"SGD:S000003454","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR222W"}


id: YGR223C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00115":null,"YGR223C":null},"has_protein_features":false,"name":"HSV2","ortholog_annotations":[{"gene_uniquename":"YGR223C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00115","reference_uniquename":"PMID:29761456"}],"product":"Phosphoinositide (PI) binding protein; involved in micronucleophagy; belongs to the PROPPIN family of proteins defined by a seven-bladed beta-propeller fold and FRRG motif required for PI binding; displays punctate cytoplasmic localization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR223C"}


id: YGR224W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01336":null,"SJAG_01636":null,"SJAG_01923":null,"SJAG_04715":null,"SJAG_04983":null,"YGR224W":null},"has_protein_features":false,"name":"AZR1","ortholog_annotations":[{"gene_uniquename":"YGR224W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01336","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR224W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01636","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR224W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01923","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR224W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04715","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR224W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04983","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane transporter of the major facilitator superfamily; involved in resistance to azole drugs such as ketoconazole and fluconazole","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003456","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR224W"}


id: YGR225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03809":null,"SJAG_03858":null,"YGR225W":null},"has_protein_features":false,"name":"AMA1","ortholog_annotations":[{"gene_uniquename":"YGR225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03809","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGR225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03858","reference_uniquename":"PMID:29761456"}],"product":"Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis; prevents premature assembly of the meiosis I spindle, required for DSB induced prophase I arrest","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003457","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR225W"}


id: YGR226C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W","secondary_identifier":"SGD:S000003458","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR226C"}


id: YGR227C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OTO1","product":"Small toxic protein; overexpression inhibits ergosterol biosynthesis; not required for normal growth, not conserved in related yeast species including S. paradoxus","secondary_identifier":"SGD:S000303806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR227C-A"}


id: YGR227W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03764":null,"YGR227W":null},"has_protein_features":false,"name":"DIE2","ortholog_annotations":[{"gene_uniquename":"YGR227W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03764","reference_uniquename":"PMID:29761456"}],"product":"Dolichyl-phosphoglucose-dependent alpha-1,2-glucosyltransferase; located in the ER; functions in pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation; has a role in regulation of ITR1 and INO1; human homolog ALG10B can complement yeast die2 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003459","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR227W"}


id: YGR228W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C","secondary_identifier":"SGD:S000003460","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR228W"}


id: YGR229C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03123":null,"YGR229C":null},"has_protein_features":false,"name":"SMI1","ortholog_annotations":[{"gene_uniquename":"YGR229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03123","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003461","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR229C"}


id: YGR230W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01341":null,"YGR230W":null},"has_protein_features":false,"name":"BNS1","ortholog_annotations":[{"gene_uniquename":"YGR230W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01341","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; FEAR network component that partially overlaps the function of SPO12 in promoting Cdc14p release from the nucleolus during early mitotic anaphase and mitotic exit; overexpression partially suppresses the meiotic defect of spo12; BNS1 has a paralog, SPO12, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003462","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR230W"}


id: YGR231C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01073":null,"YGR231C":null},"has_protein_features":false,"name":"PHB2","ortholog_annotations":[{"gene_uniquename":"YGR231C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01073","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003463","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR231C"}


id: YGR232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00954":null,"YGR232W":null},"has_protein_features":false,"name":"NAS6","ortholog_annotations":[{"gene_uniquename":"YGR232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00954","reference_uniquename":"PMID:29761456"}],"product":"Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, also known as p28, which interacts with the Rb tumor suppressor and CDK4/6","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003464","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR232W"}


id: YGR233C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PHO81","product":"Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000003465","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR233C"}


id: YGR234W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YHB1","product":"Nitric oxide oxidoreductase; flavohemoglobin that plays role in oxidative and nitrosative stress responses; protects against nitration of cellular targets and against cell growth inhibition under aerobic or anaerobic conditions; yeast flavohemoglobin Yhb1p and human homolog neuroglobin NGB protect cells against alpha-synuclein cytotoxicity and aggregate formation; protein increases in abundance, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","secondary_identifier":"SGD:S000003466","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR234W"}


id: YGR235C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02501":null,"YGR235C":null},"has_protein_features":false,"name":"MIC26","ortholog_annotations":[{"gene_uniquename":"YGR235C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02501","reference_uniquename":"PMID:29761456"}],"product":"Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic26p is a non-essential component of the complex; orthologous to human APOO and APOOL","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003467","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR235C"}


id: YGR236C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPG1","product":"Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000003468","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR236C"}


id: YGR237C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000003469","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR237C"}


id: YGR238C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01196":null,"SJAG_04322":null,"YGR238C":null},"has_protein_features":false,"name":"KEL2","ortholog_annotations":[{"gene_uniquename":"YGR238C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01196","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR238C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04322","reference_uniquename":"PMID:29761456"}],"product":"Protein that negatively regulates mitotic exit; forms a complex with Kel1p and Bud14p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; functions in a complex with Kel1p, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003470","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR238C"}


id: YGR239C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEX21","product":"Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; constitutively expressed; partially redundant with Pex18p; required for import of the Gpd1p-Pnc1p heterodimer in which only Gpd1p has a peroxisomal targeting signal; relative distribution to cytoplasmic foci increases upon DNA replication stress","secondary_identifier":"SGD:S000003471","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR239C"}


id: YGR240C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00605":null,"YGR240C":null},"has_protein_features":false,"name":"PFK1","ortholog_annotations":[{"gene_uniquename":"YGR240C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00605","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of heterooctameric phosphofructokinase; involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR240C"}


id: YGR240C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028551","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR240C-A"}


id: YGR241C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01748":null,"YGR241C":null},"has_protein_features":false,"name":"YAP1802","ortholog_annotations":[{"gene_uniquename":"YGR241C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01748","reference_uniquename":"PMID:29761456"}],"product":"Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003473","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR241C"}


id: YGR242W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C","secondary_identifier":"SGD:S000003474","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR242W"}


id: YGR243W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04593":null,"YGR243W":null},"has_protein_features":false,"name":"MPC3","ortholog_annotations":[{"gene_uniquename":"YGR243W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04593","reference_uniquename":"PMID:29761456"}],"product":"Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on nonfermentable carbon sources, and heterodimerizes with Mpc1p to form the respiratory isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC3 paralog, MPC2, heterodimerizes with Mpc1p to form the fermentative MPC isoform; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003475","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR243W"}


id: YGR244C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03813":null,"YGR244C":null},"has_protein_features":false,"name":"LSC2","ortholog_annotations":[{"gene_uniquename":"YGR244C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03813","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003476","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR244C"}


id: YGR245C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04308":null,"YGR245C":null},"has_protein_features":false,"name":"SDA1","ortholog_annotations":[{"gene_uniquename":"YGR245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04308","reference_uniquename":"PMID:29761456"}],"product":"Protein required for actin organization and passage through Start; highly conserved nuclear protein; required for actin cytoskeleton organization; plays a critical role in G1 events; binds Nap1p; involved in 60S ribosome biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003477","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR245C"}


id: YGR246C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03120":null,"YGR246C":null},"has_protein_features":false,"name":"BRF1","ortholog_annotations":[{"gene_uniquename":"YGR246C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03120","reference_uniquename":"PMID:29761456"}],"product":"TFIIIB B-related factor; one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB; mutations in human homolog are associated with autosomal recessive cerebellar-facial-dental syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003478","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR246C"}


id: YGR247W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01428":null,"YGR247W":null},"has_protein_features":false,"name":"CPD1","ortholog_annotations":[{"gene_uniquename":"YGR247W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01428","reference_uniquename":"PMID:29761456"}],"product":"Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003479","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR247W"}


id: YGR248W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01824":null,"YGR248W":null},"has_protein_features":false,"name":"SOL4","ortholog_annotations":[{"gene_uniquename":"YGR248W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01824","reference_uniquename":"PMID:29761456"}],"product":"6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003480","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR248W"}


id: YGR249W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MGA1","product":"Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants","secondary_identifier":"SGD:S000003481","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR249W"}


id: YGR250C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RIE1","product":"RNA binding protein and negative regulator of START; binds mRNA of the G1 cyclin CLN3 to stress granules for translational repression under conditions of stress; recruits the cyclin-dependent protein kinase Cdc28p to stress granules when stressful conditions are relieved, resulting in the dissolution of the granules, and resumption of translation; localizes to stress granules induced by glucose deprivation; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003482","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR250C"}


id: YGR251W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NOP19","product":"Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes","secondary_identifier":"SGD:S000003483","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR251W"}


id: YGR252W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02773":null,"YGR252W":null},"has_protein_features":false,"name":"GCN5","ortholog_annotations":[{"gene_uniquename":"YGR252W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02773","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of ADA and SAGA histone acetyltransferase complexes; modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; relocalizes to the cytosol in response to hypoxia; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003484","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR252W"}


id: YGR253C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05316":null,"YGR253C":null},"has_protein_features":false,"name":"PUP2","ortholog_annotations":[{"gene_uniquename":"YGR253C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05316","reference_uniquename":"PMID:29761456"}],"product":"Alpha 5 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit zeta","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003485","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR253C"}


id: YGR254W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00461":null,"SJAG_02107":null,"SJAG_02369":null,"YGR254W":null},"has_protein_features":false,"name":"ENO1","ortholog_annotations":[{"gene_uniquename":"YGR254W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00461","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR254W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02107","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR254W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02369","reference_uniquename":"PMID:29761456"}],"product":"Enolase I, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression repressed in response to glucose; protein abundance increases in response to DNA replication stress; N-terminally propionylated in vivo; ENO1 has a paralog, ENO2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003486","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR254W"}


id: YGR255C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04000":null,"YGR255C":null},"has_protein_features":false,"name":"COQ6","ortholog_annotations":[{"gene_uniquename":"YGR255C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04000","reference_uniquename":"PMID:29761456"}],"product":"Flavin-dependent monooxygenase involved in ubiquinone biosynthesis; responsible for hydroxylation at position C5 and deamination at C4 during ubiquinone (Coenzyme Q) biosynthesis; localizes to matrix face of mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human homolog COQ6 can complement yeast null mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003487","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR255C"}


id: YGR256W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03852":null,"YGR256W":null},"has_protein_features":false,"name":"GND2","ortholog_annotations":[{"gene_uniquename":"YGR256W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03852","reference_uniquename":"PMID:29761456"}],"product":"6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003488","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR256W"}


id: YGR257C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03577":null,"YGR257C":null},"has_protein_features":false,"name":"MTM1","ortholog_annotations":[{"gene_uniquename":"YGR257C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03577","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein of the mitochondrial carrier family; high affinity pyridoxal 5'-phosphate (PLP) transporter, important for delivery of the PLP cofactor to mitochondrial enzymes; involved in mitochondrial iron homeostasis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003489","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR257C"}


id: YGR258C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02031":null,"YGR258C":null},"has_protein_features":false,"name":"RAD2","ortholog_annotations":[{"gene_uniquename":"YGR258C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02031","reference_uniquename":"PMID:29761456"}],"product":"Single-stranded DNA endonuclease; cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003490","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR258C"}


id: YGR259C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W","secondary_identifier":"SGD:S000003491","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR259C"}


id: YGR260W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04706":null,"YGR260W":null},"has_protein_features":false,"name":"TNA1","ortholog_annotations":[{"gene_uniquename":"YGR260W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04706","reference_uniquename":"PMID:29761456"}],"product":"High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003492","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR260W"}


id: YGR261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02453":null,"YGR261C":null},"has_protein_features":false,"name":"APL6","ortholog_annotations":[{"gene_uniquename":"YGR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02453","reference_uniquename":"PMID:29761456"}],"product":"Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003493","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR261C"}


id: YGR262C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00378":null,"YGR262C":null},"has_protein_features":false,"name":"BUD32","ortholog_annotations":[{"gene_uniquename":"YGR262C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00378","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase; component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; Pyrococcus Bud32 ortholog functions as a P-loop ATPase rather than a protein kinase in the context of the complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; mutation is functionally complemented by human TP53RK","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003494","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR262C"}


id: YGR263C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SAY1","product":"Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; active both in the endoplasmic reticulum (ER) and in lipid droplets; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the ER","secondary_identifier":"SGD:S000003495","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR263C"}


id: YGR264C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01159":null,"YGR264C":null},"has_protein_features":false,"name":"MES1","ortholog_annotations":[{"gene_uniquename":"YGR264C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01159","reference_uniquename":"PMID:29761456"}],"product":"Methionyl-tRNA synthetase; forms a complex with Gus1p, a glutamyl-tRNA synthetase, and Arc1p, which increases the catalytic efficiency of both synthetases; involved in the nuclear export of tRNAs; mutations in human ortholog MARS is associated with pediatric pulmonary alveolar proteinosis, interstitial lung and liver disease, and Charcot-Marie-Tooth disease; human MARS gene can complement the yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003496","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR264C"}


id: YGR265W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase","secondary_identifier":"SGD:S000003497","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR265W"}


id: YGR266W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003498","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR266W"}


id: YGR267C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03275":null,"YGR267C":null},"has_protein_features":false,"name":"FOL2","ortholog_annotations":[{"gene_uniquename":"YGR267C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03275","reference_uniquename":"PMID:29761456"}],"product":"GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis; human homolog GCH1 is implicated in dopa-responsive dystonia (DRD), and can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003499","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR267C"}


id: YGR268C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03273":null,"YGR268C":null},"has_protein_features":false,"name":"HUA1","ortholog_annotations":[{"gene_uniquename":"YGR268C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03273","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic protein containing a zinc finger domain; sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003500","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR268C"}


id: YGR269W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C","secondary_identifier":"SGD:S000003501","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR269W"}


id: YGR270C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YTA7/YGR270W","secondary_identifier":"SGD:S000028641","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR270C-A"}


id: YGR270W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02906":null,"SJAG_04692":null,"YGR270W":null},"has_protein_features":false,"name":"YTA7","ortholog_annotations":[{"gene_uniquename":"YGR270W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02906","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR270W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04692","reference_uniquename":"PMID:29761456"}],"product":"Chromatin-binding ATPase that regulates histone gene expression; only bromodomain-containing AAA-ATPase in yeast; bromodomain interacts with N-terminal tail of histone H3; relocalizes to cytosol in response to hypoxia; human ortholog ANCCA is coactivator of both estrogen and androgen receptors, and increased expression of ANCCA is associated with breast and prostate cancers with poor prognoses","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003502","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR270W"}


id: YGR271C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00562":null,"YGR271C-A":null},"has_protein_features":false,"name":"EFG1","ortholog_annotations":[{"gene_uniquename":"YGR271C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00562","reference_uniquename":"PMID:29761456"}],"product":"Ribosome biogenesis factor required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR271C-A"}


id: YGR271W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00898":null,"YGR271W":null},"has_protein_features":false,"name":"SLH1","ortholog_annotations":[{"gene_uniquename":"YGR271W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00898","reference_uniquename":"PMID:29761456"}],"product":"Subunit of ribosome-associated quality control trigger complex (RQT); putative RNA helicase related to Ski2p; involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses; human homolog is ASCC3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003503","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR271W"}


id: YGR272C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein;YGR272C was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YGR271C-A","secondary_identifier":"SGD:S000003504","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR272C"}


id: YGR273C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01255":null,"SJAG_04659":null,"YGR273C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR273C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01255","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR273C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04659","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; not an essential gene; YGR273C has a paralog, YMR295C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003505","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR273C"}


id: YGR274C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03900":null,"YGR274C":null},"has_protein_features":false,"name":"TAF1","ortholog_annotations":[{"gene_uniquename":"YGR274C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03900","reference_uniquename":"PMID:29761456"}],"product":"TFIID subunit, involved in RNA pol II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003506","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR274C"}


id: YGR275W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RTT102","product":"Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003507","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR275W"}


id: YGR276C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02993":null,"YGR276C":null},"has_protein_features":false,"name":"RNH70","ortholog_annotations":[{"gene_uniquename":"YGR276C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02993","reference_uniquename":"PMID:29761456"}],"product":"3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003508","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR276C"}


id: YGR277C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05277":null,"YGR277C":null},"has_protein_features":false,"name":"CAB4","ortholog_annotations":[{"gene_uniquename":"YGR277C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05277","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; involved in histone acylation; probable pantetheine-phosphate adenylyltransferase (PPAT); PPAT catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT) and by human COASY","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003509","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR277C"}


id: YGR278W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_16453":null,"YGR278W":null},"has_protein_features":false,"name":"CWC22","ortholog_annotations":[{"gene_uniquename":"YGR278W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16453","reference_uniquename":"PMID:29761456"}],"product":"Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003510","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR278W"}


id: YGR279C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SCW4","product":"Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating; SCW4 has a paralog, SCW10, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003511","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR279C"}


id: YGR280C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02758":null,"YGR280C":null},"has_protein_features":false,"name":"PXR1","ortholog_annotations":[{"gene_uniquename":"YGR280C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02758","reference_uniquename":"PMID:29761456"}],"product":"Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003512","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR280C"}


id: YGR281W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01344":null,"SJAG_03785":null,"SJAG_05213":null,"YGR281W":null},"has_protein_features":false,"name":"YOR1","ortholog_annotations":[{"gene_uniquename":"YGR281W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01344","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR281W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03785","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR281W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05213","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter mediates export of many different organic anions including oligomycin; homolog of human cystic fibrosis transmembrane receptor (CFTR)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003513","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR281W"}


id: YGR282C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02192":null,"YGR282C":null},"has_protein_features":false,"name":"BGL2","ortholog_annotations":[{"gene_uniquename":"YGR282C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02192","reference_uniquename":"PMID:29761456"}],"product":"Endo-beta-1,3-glucanase; major protein of the cell wall, involved in cell wall maintenance; involved in incorporation of newly synthesized mannoprotein molecules into the cell wall","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003514","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR282C"}


id: YGR283C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03554":null,"YGR283C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR283C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03554","reference_uniquename":"PMID:29761456"}],"product":"Putative methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus; YGR283C has a paralog, YMR310C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003515","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR283C"}


id: YGR284C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02120":null,"YGR284C":null},"has_protein_features":false,"name":"ERV29","ortholog_annotations":[{"gene_uniquename":"YGR284C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02120","reference_uniquename":"PMID:29761456"}],"product":"Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003516","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR284C"}


id: YGR285C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03094":null,"YGR285C":null},"has_protein_features":false,"name":"ZUO1","ortholog_annotations":[{"gene_uniquename":"YGR285C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03094","reference_uniquename":"PMID:29761456"}],"product":"Ribosome-associated chaperone; zuotin functions in ribosome biogenesis and as a chaperone for nascent polypeptide chains in partnership with Ssz1p and SSb1/2; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p; human gene DNAJC2 can partially complement yeast zuo1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003517","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR285C"}


id: YGR286C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01935":null,"YGR286C":null},"has_protein_features":false,"name":"BIO2","ortholog_annotations":[{"gene_uniquename":"YGR286C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01935","reference_uniquename":"PMID:29761456"}],"product":"Biotin synthase; catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003518","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR286C"}


id: YGR287C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IMA1","product":"Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; member of the IMA isomaltase family","secondary_identifier":"SGD:S000003519","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR287C"}


id: YGR288W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MAL13","product":"MAL-activator protein; part of complex locus MAL1; nonfunctional in genomic reference strain S288C","secondary_identifier":"SGD:S000003520","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR288W"}


id: YGR289C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04905":null,"YGR289C":null},"has_protein_features":false,"name":"MAL11","ortholog_annotations":[{"gene_uniquename":"YGR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"High-affinity maltose transporter (alpha-glucoside transporter); inducible; encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR289C"}


id: YGR290W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)","secondary_identifier":"SGD:S000003522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR290W"}


id: YGR291C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR291C"}


id: YGR292W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MAL12","product":"Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose","secondary_identifier":"SGD:S000003524","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR292W"}


id: YGR293C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR294W","secondary_identifier":"SGD:S000003525","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR293C"}


id: YGR294W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU12","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to both the endoplasmic reticulum and vacuole","secondary_identifier":"SGD:S000003526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR294W"}


id: YGR295C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COS6","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000003527","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR295C"}


id: YGR296C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps TEL07R","secondary_identifier":"SGD:S000028642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR296C-A"}


id: YGR296C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; contained completely within TEL07R","secondary_identifier":"SGD:S000028643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR296C-B"}


id: YGR296W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YRF1-3","product":"Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p","secondary_identifier":"SGD:S000003528","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR296W"}


id: YHL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01364":null,"SJAG_02890":null,"YHL001W":null},"has_protein_features":false,"name":"RPL14B","ortholog_annotations":[{"gene_uniquename":"YHL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01364","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02890","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000993","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL001W"}


id: YHL002C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF HSE1/YHL002W","secondary_identifier":"SGD:S000028770","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL002C-A"}


id: YHL002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00821":null,"YHL002W":null},"has_protein_features":false,"name":"HSE1","ortholog_annotations":[{"gene_uniquename":"YHL002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00821","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000994","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL002W"}


id: YHL003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02085":null,"SJAG_02842":null,"YHL003C":null},"has_protein_features":false,"name":"LAG1","ortholog_annotations":[{"gene_uniquename":"YHL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02085","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02842","reference_uniquename":"PMID:29761456"}],"product":"Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enhances invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000995","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL003C"}


id: YHL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03584":null,"YHL004W":null},"has_protein_features":false,"name":"MRP4","ortholog_annotations":[{"gene_uniquename":"YHL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03584","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000996","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL004W"}


id: YHL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YHL005C is not an essential gene","secondary_identifier":"SGD:S000000997","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL005C"}


id: YHL006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SHU1","product":"Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu2, and promotes error-free DNA repair, mediates inhibition of Srs2p function; essential for promoting the establishment of homolog bias during meiotic homologous recombination; promotes both crossover (CO) and non-crossover (NCO) pathways of meiotic recombination and formation of Rad51p filaments","secondary_identifier":"SGD:S000000998","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL006C"}


id: YHL006W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF STE20/YHL007C","secondary_identifier":"SGD:S000028771","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL006W-A"}


id: YHL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00845":null,"SJAG_02878":null,"YHL007C":null},"has_protein_features":false,"name":"STE20","ortholog_annotations":[{"gene_uniquename":"YHL007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00845","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02878","reference_uniquename":"PMID:26896847"}],"product":"Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000999","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL007C"}


id: YHL008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000001000","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL008C"}


id: YHL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YAP3","product":"Basic leucine zipper (bZIP) transcription factor","secondary_identifier":"SGD:S000001001","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL009C"}


id: YHL010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00509":null,"YHL010C":null},"has_protein_features":false,"name":"ETP1","ortholog_annotations":[{"gene_uniquename":"YHL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00509","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001002","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL010C"}


id: YHL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03811":null,"YHL011C":null},"has_protein_features":false,"name":"PRS3","ortholog_annotations":[{"gene_uniquename":"YHL011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03811","reference_uniquename":"PMID:29761456"}],"product":"5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001003","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL011C"}


id: YHL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01089":null,"SJAG_02178":null,"YHL012W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01089","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02178","reference_uniquename":"PMID:29761456"}],"product":"Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001004","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL012W"}


id: YHL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02774":null,"YHL013C":null},"has_protein_features":false,"name":"OTU2","ortholog_annotations":[{"gene_uniquename":"YHL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02774","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001005","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL013C"}


id: YHL014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04874":null,"YHL014C":null},"has_protein_features":false,"name":"YLF2","ortholog_annotations":[{"gene_uniquename":"YHL014C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04874","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function; has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001006","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL014C"}


id: YHL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04476":null,"YHL015W":null},"has_protein_features":false,"name":"RPS20","ortholog_annotations":[{"gene_uniquename":"YHL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04476","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001007","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL015W"}


id: YHL015W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028828","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL015W-A"}


id: YHL016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02125":null,"YHL016C":null},"has_protein_features":false,"name":"DUR3","ortholog_annotations":[{"gene_uniquename":"YHL016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02125","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane transporter for both urea and polyamines; expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001008","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL016C"}


id: YHL017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02193":null,"SJAG_02823":null,"YHL017W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHL017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02193","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02823","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001009","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL017W"}


id: YHL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MCO14","product":"Putative 4a-hydroxytetrahydrobiopterin dehydratase; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000001010","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL018W"}


id: YHL019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"APM2","product":"Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport","secondary_identifier":"SGD:S000001011","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL019C"}


id: YHL019W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene APM2/YHL019C","secondary_identifier":"SGD:S000028772","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL019W-A"}


id: YHL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OPI1","product":"Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance; null exhibits disrupted mitochondrial metabolism and low cardiolipin content, strongly correlated with overproduction of inositol; binds to phosphatidic acid","secondary_identifier":"SGD:S000001012","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL020C"}


id: YHL021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AIM17","product":"Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss","secondary_identifier":"SGD:S000001013","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL021C"}


id: YHL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05295":null,"YHL022C":null},"has_protein_features":false,"name":"SPO11","ortholog_annotations":[{"gene_uniquename":"YHL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05295","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein required for meiotic recombination; makes DNA double-strand breaks (DSB) during meiotic recombination, homolog pairing, and synaptonemal complex formation; role in meiotic DSB formation involves a topo-II-like transesterase mechanism; forms monotetrameric complex; covalently linked to DSBs through a 5'-phosphodiester bond between a catalytic tyrosine (Y135) and the DSB 5'- end; sequence similarity to a topo VI subunit from archaea, fission yeast rec12 and human SPO11","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001014","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL022C"}


id: YHL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01184":null,"YHL023C":null},"has_protein_features":false,"name":"NPR3","ortholog_annotations":[{"gene_uniquename":"YHL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01184","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of SEAC, a coatomer-related complex that associates dynamically with the vacuole; Npr3p may have a structural or regulatory role, supporting Iml1p function as a GAP for the Rag family GTPase Gtr1p, and leading to inhibition of TORC1 signaling in response to amino acid deprivation; SEACIT is required for non-nitrogen-starvation-induced autophagy; null mutant has meiotic defects; human NPRL3 homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001015","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL023C"}


id: YHL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01919":null,"YHL024W":null},"has_protein_features":false,"name":"RIM4","ortholog_annotations":[{"gene_uniquename":"YHL024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01919","reference_uniquename":"PMID:29761456"}],"product":"Putative RNA-binding protein; involved in regulation of early and middle sporulation genes; forms amyloid-like aggregates under starvation that are active in translational repression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001016","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL024W"}


id: YHL025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNF6","product":"Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions","secondary_identifier":"SGD:S000001017","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL025W"}


id: YHL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02612":null,"YHL026C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02612","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; SWAT-GFP fusion protein localizes to the cell periphery, while mCherry fusion localizes to both the cell periphery and vacuole; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001018","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL026C"}


id: YHL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RIM101","product":"Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC","secondary_identifier":"SGD:S000001019","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL027W"}


id: YHL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02258":null,"YHL028W":null},"has_protein_features":false,"name":"WSC4","ortholog_annotations":[{"gene_uniquename":"YHL028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02258","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum (ER) membrane protein; involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001020","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL028W"}


id: YHL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OCA5","product":"Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts","secondary_identifier":"SGD:S000001021","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL029C"}


id: YHL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00126":null,"YHL030W":null},"has_protein_features":false,"name":"ECM29","ortholog_annotations":[{"gene_uniquename":"YHL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00126","reference_uniquename":"PMID:29761456"}],"product":"Scaffold protein; assists in association of proteasome core particle with regulatory particle; inhibitor of proteasome in vivo and in vitro; inhibits proteasomal ATPase activity; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001022","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL030W"}


id: YHL030W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene GOS1/YHL031C","secondary_identifier":"SGD:S000028773","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL030W-A"}


id: YHL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04739":null,"YHL031C":null},"has_protein_features":false,"name":"GOS1","ortholog_annotations":[{"gene_uniquename":"YHL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04739","reference_uniquename":"PMID:29761456"}],"product":"v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001023","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL031C"}


id: YHL032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GUT1","product":"Glycerol kinase; converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p","secondary_identifier":"SGD:S000001024","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL032C"}


id: YHL033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00537":null,"YHL033C":null},"has_protein_features":false,"name":"RPL8A","ortholog_annotations":[{"gene_uniquename":"YHL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00537","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB during assembly of large subunit; binds Domain I of 25S, 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; RPL8A has paralog RPL8B from whole genome duplication; RPL8A or RPL8B ribosomes not functionally interchangeable; proportions of Rpl8ap, Rpl8bp in 80S ribosome differ in glucose and glycerol; homologous to mammalian ribosomal protein L7A, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001025","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL033C"}


id: YHL034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SBP1","product":"Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; binds to mRNAs under glucose starvation stress, most often in the 5' UTR; found associated with small nucleolar RNAs snR10 and snR11; SBP1 has a paralog, RNP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001026","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL034C"}


id: YHL034W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SBP1/YHL034C","secondary_identifier":"SGD:S000028774","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL034W-A"}


id: YHL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01344":null,"SJAG_03785":null,"SJAG_05213":null,"YHL035C":null},"has_protein_features":false,"name":"VMR1","ortholog_annotations":[{"gene_uniquename":"YHL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01344","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03785","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05213","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane protein; involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; VMR1 has a paralog, YBT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001027","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL035C"}


id: YHL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MUP3","product":"Low affinity methionine permease; similar to Mup1p","secondary_identifier":"SGD:S000001028","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL036W"}


id: YHL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000001029","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL037C"}


id: YHL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CBP2","product":"Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene","secondary_identifier":"SGD:S000001030","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL038C"}


id: YHL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02692":null,"SJAG_03228":null,"YHL039W":null},"has_protein_features":false,"name":"EFM1","ortholog_annotations":[{"gene_uniquename":"YHL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02692","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03228","reference_uniquename":"PMID:29761456"}],"product":"Lysine methyltransferase; involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001031","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL039W"}


id: YHL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YHL040C":null},"has_protein_features":false,"name":"ARN1","ortholog_annotations":[{"gene_uniquename":"YHL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001032","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL040C"}


id: YHL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000001033","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL041W"}


id: YHL042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Endoplasmic reticulum protein; member of DUP380 subfamily of conserved, often subtelomerically-encoded proteins; may contribute to maintenance of ER and nuclear morphology; null mutants have distorted nuclear envelope shape, and discontinuous, misshapen perinuclear ER","secondary_identifier":"SGD:S000001034","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL042W"}


id: YHL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ECM34","product":"Protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; SWAT-GFP, seamless-GFP and mCherry C-terminal fusion proteins localize to the cytosol","secondary_identifier":"SGD:S000001035","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL043W"}


id: YHL044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative integral membrane protein; member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern","secondary_identifier":"SGD:S000001036","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL044W"}


id: YHL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; not an essential gene","secondary_identifier":"SGD:S000001037","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL045W"}


id: YHL046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU13","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","secondary_identifier":"SGD:S000001038","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL046C"}


id: YHL046W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF ARN2/YHL047C","secondary_identifier":"SGD:S000028775","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL046W-A"}


id: YHL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YHL047C":null},"has_protein_features":false,"name":"ARN2","ortholog_annotations":[{"gene_uniquename":"YHL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"Transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001039","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL047C"}


id: YHL048C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028829","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL048C-A"}


id: YHL048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COS8","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000001040","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL048W"}


id: YHL049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001041","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL049C"}


id: YHL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; potential Cdc28p substrate","secondary_identifier":"SGD:S000001042","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL050C"}


id: YHL050W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL050W-A"}


id: YHR001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01590":null,"SJAG_02323":null,"SJAG_02375":null,"SJAG_03718":null,"YHR001W":null},"has_protein_features":false,"name":"OSH7","ortholog_annotations":[{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01590","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02323","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02375","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03718","reference_uniquename":"PMID:29761456"}],"product":"Oxysterol-binding phosphatidylserine transferase; part of family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH7 has a paralog, OSH6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001043","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR001W"}


id: YHR001W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_07006":null,"YHR001W-A":null},"has_protein_features":false,"name":"QCR10","ortholog_annotations":[{"gene_uniquename":"YHR001W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07006","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ubiqunol-cytochrome c oxidoreductase complex; this complex comprises part of the mitochondrial respiratory chain; members include Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003529","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR001W-A"}


id: YHR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03452":null,"YHR002W":null},"has_protein_features":false,"name":"LEU5","ortholog_annotations":[{"gene_uniquename":"YHR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03452","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial carrier protein; involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein SLC25A16, which complements yeast null mutant; does not encode an isozyme of Leu4p, as first hypothesized","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001044","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR002W"}


id: YHR003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02084":null,"YHR003C":null},"has_protein_features":false,"name":"TCD1","ortholog_annotations":[{"gene_uniquename":"YHR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02084","reference_uniquename":"PMID:29761456"}],"product":"tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD1 has a paralog, TCD2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001045","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR003C"}


id: YHR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01906":null,"YHR004C":null},"has_protein_features":false,"name":"NEM1","ortholog_annotations":[{"gene_uniquename":"YHR004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01906","reference_uniquename":"PMID:29761456"}],"product":"Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001046","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR004C"}


id: YHR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02233":null,"SJAG_02444":null,"YHR005C":null},"has_protein_features":false,"name":"GPA1","ortholog_annotations":[{"gene_uniquename":"YHR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02233","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02444","reference_uniquename":"PMID:26896847"}],"product":"Subunit of G protein involved in pheromone response; GTP-binding alpha subunit of heterotrimeric G protein; negatively regulates mating pathway by sequestering G(beta)gamma and triggering an adaptive response; activates Vps34p at endosome; protein abundance increases in response to DNA replication stress; mutations in human homolog GNAS associated with McCune-Albright syndrome","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001047","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR005C"}


id: YHR005C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00687":null,"YHR005C-A":null},"has_protein_features":false,"name":"TIM10","ortholog_annotations":[{"gene_uniquename":"YHR005C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00687","reference_uniquename":"PMID:29761456"}],"product":"Essential protein of the mitochondrial intermembrane space; forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003530","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR005C-A"}


id: YHR006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"STP2","product":"Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001048","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR006W"}


id: YHR007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03750":null,"YHR007C":null},"has_protein_features":false,"name":"ERG11","ortholog_annotations":[{"gene_uniquename":"YHR007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03750","reference_uniquename":"PMID:29761456"}],"product":"Lanosterol 14-alpha-demethylase; catalyzes C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in ergosterol biosynthesis pathway; transcriptionally down-regulated when ergosterol is in excess; member of cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; human CYP51A1 functionally complements the lethality of the erg11 null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001049","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR007C"}


id: YHR007C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry; SWAT-GFP fusion protein localizes to the nucleus","secondary_identifier":"SGD:S000028830","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR007C-A"}


id: YHR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03303":null,"YHR008C":null},"has_protein_features":false,"name":"SOD2","ortholog_annotations":[{"gene_uniquename":"YHR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03303","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity and oxidative stress; human mitochondrial SOD2 can complement a yeast null mutant and human cytoplasmic SOD1 can also complement when targeted to the mitochondrial matrix","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001050","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR008C"}


id: YHR009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00287":null,"SJAG_04359":null,"YHR009C":null},"has_protein_features":false,"name":"TDA3","ortholog_annotations":[{"gene_uniquename":"YHR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00287","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04359","reference_uniquename":"PMID:29761456"}],"product":"Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001051","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR009C"}


id: YHR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01588":null,"SJAG_02802":null,"YHR010W":null},"has_protein_features":false,"name":"RPL27A","ortholog_annotations":[{"gene_uniquename":"YHR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01588","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02802","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001052","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR010W"}


id: YHR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02977":null,"YHR011W":null},"has_protein_features":false,"name":"DIA4","ortholog_annotations":[{"gene_uniquename":"YHR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02977","reference_uniquename":"PMID:29761456"}],"product":"Probable mitochondrial seryl-tRNA synthetase; mutant displays increased invasive and pseudohyphal growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001053","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR011W"}


id: YHR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04629":null,"YHR012W":null},"has_protein_features":false,"name":"VPS29","ortholog_annotations":[{"gene_uniquename":"YHR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04629","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the membrane-associated retromer complex; endosomal protein; essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001054","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR012W"}


id: YHR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04631":null,"YHR013C":null},"has_protein_features":false,"name":"ARD1","ortholog_annotations":[{"gene_uniquename":"YHR013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04631","reference_uniquename":"PMID:29761456"}],"product":"Subunit of protein N-terminal acetyltransferase NatA; NatA comprises Nat1p, Ard1p, Nat5p; acetylates many proteins to influence telomeric silencing, cell cycle, heat-shock resistance, mating, sporulation, early stages of mitophagy; protein abundance increases under DNA replication stress; mutations in human homolog X-linked NAA10 lead to Ogden syndrome (S37P) and intellectual disability (R116W); expression of human NAA10 and NAA15 can complement ard1 nat1 double mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001055","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR013C"}


id: YHR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPO13","product":"Meiotic regulator; involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II; anaphase-promoting complex (APC) substrate that is degraded during anaphase I; expressed only in meiotic cells","secondary_identifier":"SGD:S000001056","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR014W"}


id: YHR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MIP6","product":"Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001057","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR015W"}


id: YHR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00970":null,"YHR016C":null},"has_protein_features":false,"name":"YSC84","ortholog_annotations":[{"gene_uniquename":"YHR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00970","reference_uniquename":"PMID:29761456"}],"product":"Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001058","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR016C"}


id: YHR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04124":null,"YHR017W":null},"has_protein_features":false,"name":"YSC83","ortholog_annotations":[{"gene_uniquename":"YHR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04124","reference_uniquename":"PMID:29761456"}],"product":"Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001059","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR017W"}


id: YHR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01461":null,"YHR018C":null},"has_protein_features":false,"name":"ARG4","ortholog_annotations":[{"gene_uniquename":"YHR018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01461","reference_uniquename":"PMID:29761456"}],"product":"Argininosuccinate lyase; catalyzes the final step in the arginine biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001060","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR018C"}


id: YHR019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02517":null,"YHR019C":null},"has_protein_features":false,"name":"DED81","ortholog_annotations":[{"gene_uniquename":"YHR019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02517","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic asparaginyl-tRNA synthetase; required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001061","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR019C"}


id: YHR020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01259":null,"YHR020W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHR020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01259","reference_uniquename":"PMID:29761456"}],"product":"Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001062","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR020W"}


id: YHR021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02340":null,"YHR021C":null},"has_protein_features":false,"name":"RPS27B","ortholog_annotations":[{"gene_uniquename":"YHR021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02340","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001063","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR021C"}


id: YHR021W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ECM12","product":"Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity","secondary_identifier":"SGD:S000003531","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR021W-A"}


id: YHR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YHR022C is not an essential gene","secondary_identifier":"SGD:S000001064","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR022C"}


id: YHR022C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR022C-A"}


id: YHR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02431":null,"SJAG_03703":null,"YHR023W":null},"has_protein_features":false,"name":"MYO1","ortholog_annotations":[{"gene_uniquename":"YHR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02431","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03703","reference_uniquename":"PMID:29761456"}],"product":"Type II myosin heavy chain; required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001065","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR023W"}


id: YHR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04641":null,"YHR024C":null},"has_protein_features":false,"name":"MAS2","ortholog_annotations":[{"gene_uniquename":"YHR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04641","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001066","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR024C"}


id: YHR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03141":null,"YHR025W":null},"has_protein_features":false,"name":"THR1","ortholog_annotations":[{"gene_uniquename":"YHR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03141","reference_uniquename":"PMID:29761456"}],"product":"Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulated by the GCN4-mediated general amino acid control pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001067","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR025W"}


id: YHR026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02023":null,"YHR026W":null},"has_protein_features":false,"name":"VMA16","ortholog_annotations":[{"gene_uniquename":"YHR026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02023","reference_uniquename":"PMID:29761456"}],"product":"Subunit c'' of the vacuolar ATPase; v-ATPase functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001068","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR026W"}


id: YHR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03638":null,"YHR027C":null},"has_protein_features":false,"name":"RPN1","ortholog_annotations":[{"gene_uniquename":"YHR027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03638","reference_uniquename":"PMID:29761456"}],"product":"Non-ATPase base subunit of the 19S RP of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions; RP is the acronym for regulatory particle","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001069","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR027C"}


id: YHR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02565":null,"YHR028C":null},"has_protein_features":false,"name":"DAP2","ortholog_annotations":[{"gene_uniquename":"YHR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02565","reference_uniquename":"PMID:29761456"}],"product":"Dipeptidyl aminopeptidase; synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001070","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR028C"}


id: YHR028W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF DAP2/YHR028C","secondary_identifier":"SGD:S000028776","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR028W-A"}


id: YHR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YHI9","product":"Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production","secondary_identifier":"SGD:S000001071","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR029C"}


id: YHR030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04551":null,"YHR030C":null},"has_protein_features":false,"name":"SLT2","ortholog_annotations":[{"gene_uniquename":"YHR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04551","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine MAP kinase; coordinates expression of all 19S regulatory particle assembly-chaperones (RACs) to control proteasome abundance; involved in regulating maintenance of cell wall integrity, cell cycle progression, nuclear mRNA retention in heat shock, septum assembly; required for mitophagy, pexophagy; affects recruitment of mitochondria to phagophore assembly site; plays role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001072","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR030C"}


id: YHR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03780":null,"YHR031C":null},"has_protein_features":false,"name":"RRM3","ortholog_annotations":[{"gene_uniquename":"YHR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03780","reference_uniquename":"PMID:29761456"}],"product":"DNA helicase involved in rDNA replication and Ty1 transposition; binds to and suppresses DNA damage at G4 motifs in vivo; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001073","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR031C"}


id: YHR032C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032W-A","secondary_identifier":"SGD:S000028646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR032C-A"}


id: YHR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01145":null,"SJAG_03951":null,"YHR032W":null},"has_protein_features":false,"name":"ERC1","ortholog_annotations":[{"gene_uniquename":"YHR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01145","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03951","reference_uniquename":"PMID:29761456"}],"product":"Member of the multi-drug and toxin extrusion (MATE) family; the MATE family is part of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001074","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR032W"}


id: YHR032W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A","secondary_identifier":"SGD:S000028831","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR032W-A"}


id: YHR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03457":null,"YHR033W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03457","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001075","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR033W"}


id: YHR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PIH1","product":"Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II","secondary_identifier":"SGD:S000001076","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR034C"}


id: YHR035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NEL1","product":"Activator of Sar1p GTPase activity; paralog of Sec23 but does not associate with the COPII components; not an essential gene","secondary_identifier":"SGD:S000001077","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR035W"}


id: YHR036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01422":null,"YHR036W":null},"has_protein_features":false,"name":"BRL1","ortholog_annotations":[{"gene_uniquename":"YHR036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01422","reference_uniquename":"PMID:29761456"}],"product":"Essential nuclear envelope/ER integral membrane protein; interacts and functions with Apq12p and Brr6p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, mRNA nuclear export and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; identified as a dosage suppressor of a temperature sensitive mutation in the major karyopherin, CRM1; homologous to Brr6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001078","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR036W"}


id: YHR037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02235":null,"YHR037W":null},"has_protein_features":false,"name":"PUT2","ortholog_annotations":[{"gene_uniquename":"YHR037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02235","reference_uniquename":"PMID:29761456"}],"product":"Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of human homolog ALDH4A1 causes type II hyperprolinemia (HPII), an autosomal recessive inborn error of metabolism; human homolog ALDH4A1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001079","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR037W"}


id: YHR038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03232":null,"YHR038W":null},"has_protein_features":false,"name":"RRF1","ortholog_annotations":[{"gene_uniquename":"YHR038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03232","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosome recycling factor; essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001080","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR038W"}


id: YHR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00482":null,"YHR039C":null},"has_protein_features":false,"name":"MSC7","ortholog_annotations":[{"gene_uniquename":"YHR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00482","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001081","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR039C"}


id: YHR039C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01447":null,"YHR039C-A":null},"has_protein_features":false,"name":"VMA10","ortholog_annotations":[{"gene_uniquename":"YHR039C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01447","reference_uniquename":"PMID:29761456"}],"product":"Subunit G of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002100","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR039C-A"}


id: YHR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00752":null,"YHR040W":null},"has_protein_features":false,"name":"BCD1","ortholog_annotations":[{"gene_uniquename":"YHR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00752","reference_uniquename":"PMID:29761456"}],"product":"Essential protein required for the accumulation of box C/D snoRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001082","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR040W"}


id: YHR041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04099":null,"YHR041C":null},"has_protein_features":false,"name":"SRB2","ortholog_annotations":[{"gene_uniquename":"YHR041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04099","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001083","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR041C"}


id: YHR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04270":null,"YHR042W":null},"has_protein_features":false,"name":"NCP1","ortholog_annotations":[{"gene_uniquename":"YHR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04270","reference_uniquename":"PMID:29761456"}],"product":"NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001084","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR042W"}


id: YHR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DOG2","product":"2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed; DOG2 has a paralog, DOG1, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae","secondary_identifier":"SGD:S000001085","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR043C"}


id: YHR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DOG1","product":"2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed; DOG1 has a paralog, DOG2, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae","secondary_identifier":"SGD:S000001086","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR044C"}


id: YHR045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum","secondary_identifier":"SGD:S000001087","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR045W"}


id: YHR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"INM1","product":"Inositol monophosphatase; involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate","secondary_identifier":"SGD:S000001088","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR046C"}


id: YHR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00181":null,"YHR047C":null},"has_protein_features":false,"name":"AAP1","ortholog_annotations":[{"gene_uniquename":"YHR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00181","reference_uniquename":"PMID:29761456"}],"product":"Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001089","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR047C"}


id: YHR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02344":null,"YHR048W":null},"has_protein_features":false,"name":"YHK8","ortholog_annotations":[{"gene_uniquename":"YHR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02344","reference_uniquename":"PMID:26896847"}],"product":"Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001090","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR048W"}


id: YHR049C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003532","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR049C-A"}


id: YHR049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03760":null,"YHR049W":null},"has_protein_features":false,"name":"FSH1","ortholog_annotations":[{"gene_uniquename":"YHR049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03760","reference_uniquename":"PMID:26896847"}],"product":"Lysophospholipase; hydrolyzes lysophosphatidylserine to release free fatty acid; involved in regulated cell death; localizes to both the nucleus and cytoplasm; contains a catalytic triad of Ser-His-Asp that is part of an alpha/beta hydrolase fold and a lipase motif (GXSXG); sequence similarity to Fsh2p and Fsh3p and the human candidate tumor suppressor and serine hydrolase, OVCA2","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001091","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR049W"}


id: YHR050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01007":null,"YHR050W":null},"has_protein_features":false,"name":"SMF2","ortholog_annotations":[{"gene_uniquename":"YHR050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01007","reference_uniquename":"PMID:29761456"}],"product":"Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001092","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR050W"}


id: YHR050W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028832","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR050W-A"}


id: YHR051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01355":null,"YHR051W":null},"has_protein_features":false,"name":"COX6","ortholog_annotations":[{"gene_uniquename":"YHR051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01355","reference_uniquename":"PMID:29761456"}],"product":"Subunit VI of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001093","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR051W"}


id: YHR052C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Novel ORF identified by enrichment-based proteomics","secondary_identifier":"SGD:S000303807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR052C-B"}


id: YHR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01420":null,"SJAG_01752":null,"YHR052W":null},"has_protein_features":false,"name":"CIC1","ortholog_annotations":[{"gene_uniquename":"YHR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01420","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01752","reference_uniquename":"PMID:29761456"}],"product":"Essential protein that interacts with proteasome components; has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001094","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR052W"}


id: YHR052W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps CUP1-1","secondary_identifier":"SGD:S000028647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR052W-A"}


id: YHR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CUP1-1","product":"Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-1 has a paralog, CUP1-2, that arose from a segmental duplication","secondary_identifier":"SGD:S000001095","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR053C"}


id: YHR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; partial duplicate of RSC30/YHR056C, truncated remnant of segmental duplication","secondary_identifier":"SGD:S000001096","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR054C"}


id: YHR054C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Novel ORF identified by enrichment-based proteomics","secondary_identifier":"SGD:S000303808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR054C-B"}


id: YHR054W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps CUP1-2","secondary_identifier":"SGD:S000028648","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR054W-A"}


id: YHR055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CUP1-2","product":"Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-2 has a paralog, CUP1-1, that arose from a segmental duplication","secondary_identifier":"SGD:S000001097","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR055C"}


id: YHR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RSC30","product":"Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; null mutants are osmosensitive; RSC30 has a paralog, RSC3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001098","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR056C"}


id: YHR056W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps ORF RSC30/YHR056C","secondary_identifier":"SGD:S000028777","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR056W-A"}


id: YHR057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02413":null,"YHR057C":null},"has_protein_features":false,"name":"CPR2","ortholog_annotations":[{"gene_uniquename":"YHR057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02413","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; seamless-GFP and mCherry fusion proteins localize to the vacuole, while SWAT-GFP fusion localizes to both the endoplasmic reticulum and vacuole; suppresses toxicity of slow-folding human Z-type alpha1-antitrypsin variant associated with liver cirrhosis and emphysema","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001099","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR057C"}


id: YHR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04705":null,"YHR058C":null},"has_protein_features":false,"name":"MED6","ortholog_annotations":[{"gene_uniquename":"YHR058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04705","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001100","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR058C"}


id: YHR059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00060":null,"YHR059W":null},"has_protein_features":false,"name":"FYV4","ortholog_annotations":[{"gene_uniquename":"YHR059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00060","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; required for survival upon exposure to K1 killer toxin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001101","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR059W"}


id: YHR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"VMA22","product":"Protein that is required for vacuolar H+-ATPase (V-ATPase) function; peripheral membrane protein; not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)","secondary_identifier":"SGD:S000001102","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR060W"}


id: YHR061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GIC1","product":"Rho-family GTPase interacting protein and Cdc42p effector; required with Gic2p for polarity establishment and initiation of budding; involved in recruitment of septins to the presumptive bud site; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; gic1 gic2 double mutants are defective for polarizing Cdc42p at elevated temperature, so may function both up- and downstream of Cdc42p; regulates mitotic exit; relocalizes from bud neck to nucleus upon DNA replication stress","secondary_identifier":"SGD:S000001103","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR061C"}


id: YHR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04916":null,"YHR062C":null},"has_protein_features":false,"name":"RPP1","ortholog_annotations":[{"gene_uniquename":"YHR062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04916","reference_uniquename":"PMID:29761456"}],"product":"Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001104","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR062C"}


id: YHR063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAN5","product":"2-dehydropantoate 2-reductase; part of the pantothenic acid pathway, structurally homologous to E. coli panE","secondary_identifier":"SGD:S000001105","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR063C"}


id: YHR063W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF SSZ1/YHR064C","secondary_identifier":"SGD:S000028778","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR063W-A"}


id: YHR064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01510":null,"YHR064C":null},"has_protein_features":false,"name":"SSZ1","ortholog_annotations":[{"gene_uniquename":"YHR064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01510","reference_uniquename":"PMID:29761456"}],"product":"Hsp70 protein that interacts with Zuo1p (a DnaJ homolog); interacts with Zuo1p to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001106","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR064C"}


id: YHR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04974":null,"YHR065C":null},"has_protein_features":false,"name":"RRP3","ortholog_annotations":[{"gene_uniquename":"YHR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04974","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001107","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR065C"}


id: YHR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02427":null,"YHR066W":null},"has_protein_features":false,"name":"SSF1","ortholog_annotations":[{"gene_uniquename":"YHR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02427","reference_uniquename":"PMID:29761456"}],"product":"Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001108","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR066W"}


id: YHR067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00305":null,"YHR067W":null},"has_protein_features":false,"name":"HTD2","ortholog_annotations":[{"gene_uniquename":"YHR067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00305","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial 3-hydroxyacyl-thioester dehydratase; involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001109","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR067W"}


id: YHR068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04130":null,"YHR068W":null},"has_protein_features":false,"name":"DYS1","ortholog_annotations":[{"gene_uniquename":"YHR068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04130","reference_uniquename":"PMID:29761456"}],"product":"Deoxyhypusine synthase; catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric; human homolog DHPS allows growth of yeast haploid dys1 null mutant after sporulation of heterozygous diploid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001110","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR068W"}


id: YHR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01521":null,"YHR069C":null},"has_protein_features":false,"name":"RRP4","ortholog_annotations":[{"gene_uniquename":"YHR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01521","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; mutations in the human ortholog, EXOSC2, cause SHRF (Short stature, Hearing loss, Retinitis pigmentosa and distinctive Facies) syndrome, an RNA exosomopathy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001111","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR069C"}


id: YHR069C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps ORF TRM5/YHR070W","secondary_identifier":"SGD:S000028779","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR069C-A"}


id: YHR070C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W","secondary_identifier":"SGD:S000028780","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR070C-A"}


id: YHR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00255":null,"YHR070W":null},"has_protein_features":false,"name":"TRM5","ortholog_annotations":[{"gene_uniquename":"YHR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00255","reference_uniquename":"PMID:29761456"}],"product":"tRNA(m(1)G37)methyltransferase; methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; localized to both cytoplasm and mitochondria, and modifies both cytoplasmic and mitochondrial tRNAs; mutations in human ortholog TRMT5 are associated with skeletal muscle respiratory chain deficiencies, and trm5 mutations analogous to disease mutations decrease respiration","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001112","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR070W"}


id: YHR071C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ERG7/YHR072W","secondary_identifier":"SGD:S000028781","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR071C-A"}


id: YHR071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03591":null,"YHR071W":null},"has_protein_features":false,"name":"PCL5","ortholog_annotations":[{"gene_uniquename":"YHR071W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03591","reference_uniquename":"PMID:29761456"}],"product":"Cyclin; interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001113","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR071W"}


id: YHR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00624":null,"YHR072W":null},"has_protein_features":false,"name":"ERG7","ortholog_annotations":[{"gene_uniquename":"YHR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00624","reference_uniquename":"PMID:29761456"}],"product":"Lanosterol synthase; an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis; human LSS functionally complements the lethality of the erg7 null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001114","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR072W"}


id: YHR072W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00566":null,"YHR072W-A":null},"has_protein_features":false,"name":"NOP10","ortholog_annotations":[{"gene_uniquename":"YHR072W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00566","reference_uniquename":"PMID:29761456"}],"product":"Subunit of box H/ACA snoRNP complex; required for pseudouridylation and processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR072W-A"}


id: YHR073C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028833","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR073C-B"}


id: YHR073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00355":null,"YHR073W":null},"has_protein_features":false,"name":"OSH3","ortholog_annotations":[{"gene_uniquename":"YHR073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00355","reference_uniquename":"PMID:29761456"}],"product":"Member of an oxysterol-binding protein family; this family has seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane; regulated by sterol binding","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001115","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR073W"}


id: YHR073W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028834","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR073W-A"}


id: YHR074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02618":null,"YHR074W":null},"has_protein_features":false,"name":"QNS1","ortholog_annotations":[{"gene_uniquename":"YHR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02618","reference_uniquename":"PMID:29761456"}],"product":"Glutamine-dependent NAD(+) synthetase; essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001116","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR074W"}


id: YHR075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01628":null,"YHR075C":null},"has_protein_features":false,"name":"PPE1","ortholog_annotations":[{"gene_uniquename":"YHR075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01628","reference_uniquename":"PMID:29761456"}],"product":"Protein with carboxyl methyl esterase activity; may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001117","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR075C"}


id: YHR076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01672":null,"YHR076W":null},"has_protein_features":false,"name":"PTC7","ortholog_annotations":[{"gene_uniquename":"YHR076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01672","reference_uniquename":"PMID:29761456"}],"product":"Type 2C serine/threonine protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope; activates coenzyme Q6 biosynthesis by dephosphorylation of demethoxy-Q6 hydroxylase Coq7p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001118","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR076W"}


id: YHR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05014":null,"YHR077C":null},"has_protein_features":false,"name":"NMD2","ortholog_annotations":[{"gene_uniquename":"YHR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05014","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001119","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR077C"}


id: YHR078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"High osmolarity-regulated gene of unknown function","secondary_identifier":"SGD:S000001120","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR078W"}


id: YHR079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04435":null,"YHR079C":null},"has_protein_features":false,"name":"IRE1","ortholog_annotations":[{"gene_uniquename":"YHR079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04435","reference_uniquename":"PMID:29761456"}],"product":"Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001121","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR079C"}


id: YHR079C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03221":null,"YHR079C-A":null},"has_protein_features":false,"name":"SAE3","ortholog_annotations":[{"gene_uniquename":"YHR079C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03221","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001957","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR079C-A"}


id: YHR080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01329":null,"YHR080C":null},"has_protein_features":false,"name":"LAM4","ortholog_annotations":[{"gene_uniquename":"YHR080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01329","reference_uniquename":"PMID:29761456"}],"product":"Sterol-binding protein that localizes to puncta in the cortical ER; sterol binding occurs via two StART-like domains; one of six StART-like domain-containing proteins in yeast that may be involved in intracellular sterol transfer between membranes; conserved across eukaryotes; has both GRAM and StART-like (VASt) domains; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001122","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR080C"}


id: YHR081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01191":null,"YHR081W":null},"has_protein_features":false,"name":"LRP1","ortholog_annotations":[{"gene_uniquename":"YHR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01191","reference_uniquename":"PMID:29761456"}],"product":"Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; forms a stable heterodimer with Rrp6p and regulates its exonucleolytic activity; rapidly degraded by the proteasome in the absence of Rrp6p; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001123","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR081W"}


id: YHR082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03529":null,"YHR082C":null},"has_protein_features":false,"name":"KSP1","ortholog_annotations":[{"gene_uniquename":"YHR082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03529","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001124","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR082C"}


id: YHR083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01780":null,"YHR083W":null},"has_protein_features":false,"name":"SAM35","ortholog_annotations":[{"gene_uniquename":"YHR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01780","reference_uniquename":"PMID:29761456"}],"product":"Component of the sorting and assembly machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001125","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR083W"}


id: YHR084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"STE12","product":"Transcription factor that is activated by a MAPK signaling cascade; activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth","secondary_identifier":"SGD:S000001126","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR084W"}


id: YHR085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04252":null,"YHR085W":null},"has_protein_features":false,"name":"IPI1","ortholog_annotations":[{"gene_uniquename":"YHR085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04252","reference_uniquename":"PMID:29761456"}],"product":"Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001127","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR085W"}


id: YHR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00474":null,"SJAG_02573":null,"YHR086W":null},"has_protein_features":false,"name":"NAM8","ortholog_annotations":[{"gene_uniquename":"YHR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00474","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02573","reference_uniquename":"PMID:26896847"}],"product":"RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001128","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR086W"}


id: YHR086W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","secondary_identifier":"SGD:S000028552","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR086W-A"}


id: YHR087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00487":null,"YHR087W":null},"has_protein_features":false,"name":"RTC3","ortholog_annotations":[{"gene_uniquename":"YHR087W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00487","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog is SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001129","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR087W"}


id: YHR088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04492":null,"YHR088W":null},"has_protein_features":false,"name":"RPF1","ortholog_annotations":[{"gene_uniquename":"YHR088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04492","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in assembly and export of the large ribosomal subunit; nucleolar protein; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001130","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR088W"}


id: YHR089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01234":null,"YHR089C":null},"has_protein_features":false,"name":"GAR1","ortholog_annotations":[{"gene_uniquename":"YHR089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01234","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the H/ACA snoRNP pseudouridylase complex; involved in the modification and cleavage of the 18S pre-rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001131","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR089C"}


id: YHR090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03230":null,"SJAG_03628":null,"YHR090C":null},"has_protein_features":false,"name":"YNG2","ortholog_annotations":[{"gene_uniquename":"YHR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03230","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03628","reference_uniquename":"PMID:29761456"}],"product":"Subunit of NuA4, an essential histone acetyltransferase complex; positions Piccolo NuA4 for efficient acetylation of histone H4 or histone H2A; relocalizes to the cytosol in response to hypoxia; similar to human tumor suppressor ING1 and its isoforms ING4 and ING5","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001132","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR090C"}


id: YHR091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00653":null,"YHR091C":null},"has_protein_features":false,"name":"MSR1","ortholog_annotations":[{"gene_uniquename":"YHR091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00653","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6; MSR1 has a paralog, YDR341C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001133","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR091C"}


id: YHR092C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YHR092C":null},"has_protein_features":false,"name":"HXT4","ortholog_annotations":[{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001134","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR092C"}


id: YHR093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AHT1","product":"Putative protein of unknown function; conserved across S. cerevisiae strains; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region","secondary_identifier":"SGD:S000001135","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR093W"}


id: YHR094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YHR094C":null},"has_protein_features":false,"name":"HXT1","ortholog_annotations":[{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001136","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR094C"}


id: YHR095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001137","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR095W"}


id: YHR096C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YHR096C":null},"has_protein_features":false,"name":"HXT5","ortholog_annotations":[{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001138","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR096C"}


id: YHR097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04050":null,"SJAG_05198":null,"YHR097C":null},"has_protein_features":false,"name":"PAL2","ortholog_annotations":[{"gene_uniquename":"YHR097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04050","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05198","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in clathrin-mediated endocytosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YHR097C has a paralog, PAL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001139","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR097C"}


id: YHR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02349":null,"YHR098C":null},"has_protein_features":false,"name":"SFB3","ortholog_annotations":[{"gene_uniquename":"YHR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02349","reference_uniquename":"PMID:29761456"}],"product":"Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat; COPII coat is required for cargo selection during vesicle formation in ER to Golgi transport; scaffolding function of Lst1p required to generate vesicles that can accommodate difficult cargo proteins that include large oligomeric assemblies and asymmetrically distributed membrane proteins; with Atg40p acts in autophagy of the ER; homologous to Sec24p and Sfb2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001140","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR098C"}


id: YHR099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04613":null,"SJAG_05282":null,"YHR099W":null},"has_protein_features":false,"name":"TRA1","ortholog_annotations":[{"gene_uniquename":"YHR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04613","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05282","reference_uniquename":"PMID:29761456"}],"product":"Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001141","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR099W"}


id: YHR100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03700":null,"YHR100C":null},"has_protein_features":false,"name":"GEP4","ortholog_annotations":[{"gene_uniquename":"YHR100C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03700","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase); dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001142","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR100C"}


id: YHR101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00771":null,"YHR101C":null},"has_protein_features":false,"name":"BIG1","ortholog_annotations":[{"gene_uniquename":"YHR101C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00771","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001143","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR101C"}


id: YHR102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04461":null,"YHR102W":null},"has_protein_features":false,"name":"KIC1","ortholog_annotations":[{"gene_uniquename":"YHR102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04461","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; phosphorylates Cbk1p kinase after allosteric activation by Hym1p; part of the RAM network that regulates cellular polarity and morphogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001144","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR102W"}


id: YHR103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SBE22","product":"Protein involved in bud growth; involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; SBE22 has a paralog, SBE2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001145","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR103W"}


id: YHR104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GRE3","product":"Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by HOG pathway; overexpression allows xylose fermentation in strains expressing heterologous xylitol dehydrogenase and xylulokinase; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000001146","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR104W"}


id: YHR105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YPT35","product":"Endosomal protein of unknown function; contains a phox (PX) homology domain; binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport","secondary_identifier":"SGD:S000001147","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR105W"}


id: YHR106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03653":null,"SJAG_04399":null,"YHR106W":null},"has_protein_features":false,"name":"TRR2","ortholog_annotations":[{"gene_uniquename":"YHR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03653","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04399","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001148","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR106W"}


id: YHR107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03374":null,"SJAG_03688":null,"YHR107C":null},"has_protein_features":false,"name":"CDC12","ortholog_annotations":[{"gene_uniquename":"YHR107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03374","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03688","reference_uniquename":"PMID:29761456"}],"product":"Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001149","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR107C"}


id: YHR108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02912":null,"SJAG_03756":null,"YHR108W":null},"has_protein_features":false,"name":"GGA2","ortholog_annotations":[{"gene_uniquename":"YHR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02912","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03756","reference_uniquename":"PMID:29761456"}],"product":"Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin; GGA2 has a paralog, GGA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001150","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR108W"}


id: YHR109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CTM1","product":"Cytochrome c lysine methyltransferase; trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth","secondary_identifier":"SGD:S000001151","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR109W"}


id: YHR110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04598":null,"YHR110W":null},"has_protein_features":false,"name":"ERP5","ortholog_annotations":[{"gene_uniquename":"YHR110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04598","reference_uniquename":"PMID:29761456"}],"product":"Protein with similarity to Emp24p and Erv25p; member of the p24 family involved in ER to Golgi transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001152","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR110W"}


id: YHR111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03896":null,"YHR111W":null},"has_protein_features":false,"name":"UBA4","ortholog_annotations":[{"gene_uniquename":"YHR111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03896","reference_uniquename":"PMID:29761456"}],"product":"E1-like protein that activates Urm1p before urmylation; also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001153","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR111W"}


id: YHR112C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02205":null,"YHR112C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHR112C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02205","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001154","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR112C"}


id: YHR113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03022":null,"YHR113W":null},"has_protein_features":false,"name":"APE4","ortholog_annotations":[{"gene_uniquename":"YHR113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03022","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic aspartyl aminopeptidase with possible vacuole function; Cvt pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001155","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR113W"}


id: YHR114W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04479":null,"YHR114W":null},"has_protein_features":false,"name":"BZZ1","ortholog_annotations":[{"gene_uniquename":"YHR114W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04479","reference_uniquename":"PMID:29761456"}],"product":"SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001156","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR114W"}


id: YHR115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02169":null,"YHR115C":null},"has_protein_features":false,"name":"DMA1","ortholog_annotations":[{"gene_uniquename":"YHR115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02169","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-protein ligase (E3); controls septin dynamics, spindle position checkpoint (SPOC) with ligase Dma2p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8, similar to human Chfr; contains FHA, RING fingers; DMA1 has a paralog, DMA2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001157","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR115C"}


id: YHR116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COX23","product":"Protein that functions in mitochondrial copper homeostasis; mitochondrial intermembrane space protein; essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs","secondary_identifier":"SGD:S000001158","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR116W"}


id: YHR117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04996":null,"YHR117W":null},"has_protein_features":false,"name":"TOM71","ortholog_annotations":[{"gene_uniquename":"YHR117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04996","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001159","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR117W"}


id: YHR118C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01267":null,"YHR118C":null},"has_protein_features":false,"name":"ORC6","ortholog_annotations":[{"gene_uniquename":"YHR118C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01267","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p; mutation in the human Orc6p is linked to Meier-Gorlin syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001160","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR118C"}


id: YHR119W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00769":null,"YHR119W":null},"has_protein_features":false,"name":"SET1","ortholog_annotations":[{"gene_uniquename":"YHR119W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00769","reference_uniquename":"PMID:29761456"}],"product":"Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001161","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR119W"}


id: YHR120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01807":null,"YHR120W":null},"has_protein_features":false,"name":"MSH1","ortholog_annotations":[{"gene_uniquename":"YHR120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01807","reference_uniquename":"PMID:29761456"}],"product":"DNA-binding protein of the mitochondria; involved in repair of mitochondrial DNA; has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001162","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR120W"}


id: YHR121W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LSM12","product":"Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000001163","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR121W"}


id: YHR122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00040":null,"YHR122W":null},"has_protein_features":false,"name":"CIA2","ortholog_annotations":[{"gene_uniquename":"YHR122W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00040","reference_uniquename":"PMID:29761456"}],"product":"Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation and maturation of a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001164","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR122W"}


id: YHR123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04319":null,"YHR123W":null},"has_protein_features":false,"name":"EPT1","ortholog_annotations":[{"gene_uniquename":"YHR123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04319","reference_uniquename":"PMID:29761456"}],"product":"sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001165","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR123W"}


id: YHR124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NDT80","product":"Meiosis-specific transcription factor; required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)","secondary_identifier":"SGD:S000001166","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR124W"}


id: YHR125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000001167","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR125W"}


id: YHR126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ANS1","product":"Putative GPI protein; SWAT-GFP and mCherry fusion proteins localize to the vacuole; transcription dependent upon Azf1p","secondary_identifier":"SGD:S000001168","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR126C"}


id: YHR127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis","secondary_identifier":"SGD:S000001169","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR127W"}


id: YHR128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04354":null,"SJAG_04709":null,"SJAG_04713":null,"YHR128W":null},"has_protein_features":false,"name":"FUR1","ortholog_annotations":[{"gene_uniquename":"YHR128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04354","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04709","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04713","reference_uniquename":"PMID:29761456"}],"product":"Uracil phosphoribosyltransferase; synthesizes UMP from uracil; involved in the pyrimidine salvage pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001170","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR128W"}


id: YHR129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00397":null,"SJAG_01964":null,"YHR129C":null},"has_protein_features":false,"name":"ARP1","ortholog_annotations":[{"gene_uniquename":"YHR129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00397","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01964","reference_uniquename":"PMID:26896847"}],"product":"Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001171","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR129C"}


