# genes

id: YBR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04859":null,"YBR001C":null},"has_protein_features":false,"name":"NTH2","ortholog_annotations":[{"gene_uniquename":"YBR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04859","reference_uniquename":"PMID:29761456"}],"product":"Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000205","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR001C"}


id: YBR002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02163":null,"YBR002C":null},"has_protein_features":false,"name":"RER2","ortholog_annotations":[{"gene_uniquename":"YBR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02163","reference_uniquename":"PMID:29761456"}],"product":"Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1; major enzyme of polyprenol synthesis in both the endoplasmic reticulum (ER) and in lipid droplets; participates in ER protein sorting; human ortholog DHDDS functionally complements the heat sensitive growth defect of a ts allele, and is associated with retinitis pigmentosa","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000206","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR002C"}


id: YBR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01865":null,"SJAG_04568":null,"YBR003W":null},"has_protein_features":false,"name":"COQ1","ortholog_annotations":[{"gene_uniquename":"YBR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01865","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04568","reference_uniquename":"PMID:29761456"}],"product":"Hexaprenyl pyrophosphate synthetase; catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000207","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR003W"}


id: YBR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00295":null,"YBR004C":null},"has_protein_features":false,"name":"GPI18","ortholog_annotations":[{"gene_uniquename":"YBR004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00295","reference_uniquename":"PMID:29761456"}],"product":"Functional ortholog of human PIG-V; PIG-V is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000208","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR004C"}


id: YBR005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01258":null,"YBR005W":null},"has_protein_features":false,"name":"RCR1","ortholog_annotations":[{"gene_uniquename":"YBR005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01258","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane (PM) ubiquitin ligase-substrate adaptor; involved in cell wall chitin deposition; ubiquitinates and down-regulates chitin synthase Chs3p abundance at PM via calcineurin/Crz1 signaling pathway which regulates RCR1 expression; delivered to PM by exomer complex using novel PM sorting motif; RCR1 has a paralog, RCR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000209","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR005W"}


id: YBR006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00674":null,"SJAG_03293":null,"YBR006W":null},"has_protein_features":false,"name":"UGA2","ortholog_annotations":[{"gene_uniquename":"YBR006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00674","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03293","reference_uniquename":"PMID:29761456"}],"product":"Succinate semialdehyde dehydrogenase; involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000210","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR006W"}


id: YBR007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01118":null,"YBR007C":null},"has_protein_features":false,"name":"DSF2","ortholog_annotations":[{"gene_uniquename":"YBR007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01118","reference_uniquename":"PMID:29761456"}],"product":"Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000211","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR007C"}


id: YBR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FLR1","product":"Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress","secondary_identifier":"SGD:S000000212","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR008C"}


id: YBR009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00303":null,"SJAG_00336":null,"SJAG_03542":null,"YBR009C":null},"has_protein_features":false,"name":"HHF1","ortholog_annotations":[{"gene_uniquename":"YBR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00303","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00336","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03542","reference_uniquename":"PMID:29761456"}],"product":"Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; involved in mRNA multiplexing; N-terminal domain involved in maintaining genomic integrity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000213","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR009C"}


id: YBR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00302":null,"SJAG_00335":null,"SJAG_03543":null,"YBR010W":null},"has_protein_features":false,"name":"HHT1","ortholog_annotations":[{"gene_uniquename":"YBR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00302","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00335","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03543","reference_uniquename":"PMID:29761456"}],"product":"Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000214","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR010W"}


id: YBR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02679":null,"YBR011C":null},"has_protein_features":false,"name":"IPP1","ortholog_annotations":[{"gene_uniquename":"YBR011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02679","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic inorganic pyrophosphatase (PPase); homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000215","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR011C"}


id: YBR012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by iron-regulated transcriptional activator Aft2p","secondary_identifier":"SGD:S000000216","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR012C"}


id: YBR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein; SWAT-GFP fusion protein localizes to the endoplasmic reticulum while mCherry fusion protein localizes to both the endoplasmic reticulum and vacuole","secondary_identifier":"SGD:S000000217","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR013C"}


id: YBR014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02495":null,"YBR014C":null},"has_protein_features":false,"name":"GRX7","ortholog_annotations":[{"gene_uniquename":"YBR014C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02495","reference_uniquename":"PMID:29761456"}],"product":"Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000218","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR014C"}


id: YBR015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MNN2","product":"Alpha-1,2-mannosyltransferase; responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment","secondary_identifier":"SGD:S000000219","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR015C"}


id: YBR016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02333":null,"YBR016W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBR016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02333","reference_uniquename":"PMID:29761456"}],"product":"Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000220","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR016W"}


id: YBR017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03959":null,"YBR017C":null},"has_protein_features":false,"name":"KAP104","ortholog_annotations":[{"gene_uniquename":"YBR017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03959","reference_uniquename":"PMID:29761456"}],"product":"Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR017C"}


id: YBR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02954":null,"YBR018C":null},"has_protein_features":false,"name":"GAL7","ortholog_annotations":[{"gene_uniquename":"YBR018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02954","reference_uniquename":"PMID:29761456"}],"product":"Galactose-1-phosphate uridyl transferase; synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism; human homolog UGP2 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000222","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR018C"}


id: YBR019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01784":null,"SJAG_02951":null,"SJAG_03818":null,"YBR019C":null},"has_protein_features":false,"name":"GAL10","ortholog_annotations":[{"gene_uniquename":"YBR019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01784","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02951","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03818","reference_uniquename":"PMID:29761456"}],"product":"UDP-glucose-4-epimerase; catalyzes interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers; human homolog GALE implicated in galactosemia, can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR019C"}


id: YBR020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02950":null,"YBR020W":null},"has_protein_features":false,"name":"GAL1","ortholog_annotations":[{"gene_uniquename":"YBR020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02950","reference_uniquename":"PMID:29761456"}],"product":"Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; human homolog GALK2 complements yeast null mutant; GAL1 has a paralog, GAL3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR020W"}


id: YBR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02147":null,"SJAG_04714":null,"YBR021W":null},"has_protein_features":false,"name":"FUR4","ortholog_annotations":[{"gene_uniquename":"YBR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02147","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YBR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04714","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000225","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR021W"}


id: YBR022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"POA1","product":"Phosphatase that is highly specific for ADP-ribose 1''-phosphate; a tRNA splicing metabolite; may have a role in regulation of tRNA splicing","secondary_identifier":"SGD:S000000226","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR022W"}


id: YBR023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CHS3","product":"Chitin synthase III; catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan; contains overlapping di-leucine and di-acidic signals that mediate, respectively, intracellular trafficking by AP-1 and trafficking to plasma membrane by exomer complex; requires AP-3 complex for its intracellular retention","secondary_identifier":"SGD:S000000227","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR023C"}


id: YBR024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04553":null,"YBR024W":null},"has_protein_features":false,"name":"SCO2","ortholog_annotations":[{"gene_uniquename":"YBR024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04553","reference_uniquename":"PMID:29761456"}],"product":"Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000228","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR024W"}


id: YBR025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04874":null,"YBR025C":null},"has_protein_features":false,"name":"OLA1","ortholog_annotations":[{"gene_uniquename":"YBR025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04874","reference_uniquename":"PMID:29761456"}],"product":"P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; positively regulates heat shock response; null mutant displays increased translation rate and increased readthrough of premature stop codons; protein abundance increases in response to hydrogen peroxide and to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000229","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR025C"}


id: YBR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02007":null,"YBR026C":null},"has_protein_features":false,"name":"ETR1","ortholog_annotations":[{"gene_uniquename":"YBR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02007","reference_uniquename":"PMID:29761456"}],"product":"2-enoyl thioester reductase; member of the medium chain dehydrogenase/reductase family; localized to mitochondria, where it has a probable role in fatty acid synthesis; human MECR functionally complements the respiratory growth defect of the null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR026C"}


id: YBR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YBR027C is not an essential gene","secondary_identifier":"SGD:S000000231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR027C"}


id: YBR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01047":null,"YBR028C":null},"has_protein_features":false,"name":"YPK3","ortholog_annotations":[{"gene_uniquename":"YBR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01047","reference_uniquename":"PMID:29761456"}],"product":"AGC kinase; phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner; directly phosphorylated by TORC1; phosphorylates ribosomal protein Rps6a/b (S6), in a TORC-dependent manner; undergoes autophosphorylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR028C"}


id: YBR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00426":null,"YBR029C":null},"has_protein_features":false,"name":"CDS1","ortholog_annotations":[{"gene_uniquename":"YBR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00426","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids; human homolog CDS1 can complement yeast cds1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR029C"}


id: YBR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01482":null,"YBR030W":null},"has_protein_features":false,"name":"RKM3","ortholog_annotations":[{"gene_uniquename":"YBR030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01482","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR030W"}


id: YBR031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06612":null,"YBR031W":null},"has_protein_features":false,"name":"RPL4A","ortholog_annotations":[{"gene_uniquename":"YBR031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06612","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR031W"}


id: YBR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YBR032W is not an essential gene","secondary_identifier":"SGD:S000000236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR032W"}


id: YBR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01930":null,"YBR033W":null},"has_protein_features":false,"name":"EDS1","ortholog_annotations":[{"gene_uniquename":"YBR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01930","reference_uniquename":"PMID:29761456"}],"product":"Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR033W"}


id: YBR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02756":null,"YBR034C":null},"has_protein_features":false,"name":"HMT1","ortholog_annotations":[{"gene_uniquename":"YBR034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02756","reference_uniquename":"PMID:29761456"}],"product":"Nuclear SAM-dependent mono- and asymmetric methyltransferase; modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p, ribosomal protein Rps2p, and histones H3 and H4; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR034C"}


id: YBR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01881":null,"YBR035C":null},"has_protein_features":false,"name":"PDX3","ortholog_annotations":[{"gene_uniquename":"YBR035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01881","reference_uniquename":"PMID:29761456"}],"product":"Pyridoxine (pyridoxamine) phosphate oxidase; has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR035C"}


id: YBR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CSG2","product":"Endoplasmic reticulum membrane protein; required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000000240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR036C"}


id: YBR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04553":null,"YBR037C":null},"has_protein_features":false,"name":"SCO1","ortholog_annotations":[{"gene_uniquename":"YBR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04553","reference_uniquename":"PMID:29761456"}],"product":"Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR037C"}


id: YBR038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00442":null,"SJAG_04868":null,"YBR038W":null},"has_protein_features":false,"name":"CHS2","ortholog_annotations":[{"gene_uniquename":"YBR038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00442","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04868","reference_uniquename":"PMID:29761456"}],"product":"Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR038W"}


id: YBR039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00438":null,"YBR039W":null},"has_protein_features":false,"name":"ATP3","ortholog_annotations":[{"gene_uniquename":"YBR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00438","reference_uniquename":"PMID:29761456"}],"product":"Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR039W"}


id: YBR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02351":null,"SJAG_02924":null,"YBR040W":null},"has_protein_features":false,"name":"FIG1","ortholog_annotations":[{"gene_uniquename":"YBR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02351","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02924","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR040W"}


id: YBR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FAT1","product":"Very long chain fatty acyl-CoA synthetase and fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids","secondary_identifier":"SGD:S000000245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR041W"}


id: YBR042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03935":null,"YBR042C":null},"has_protein_features":false,"name":"CST26","ortholog_annotations":[{"gene_uniquename":"YBR042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03935","reference_uniquename":"PMID:29761456"}],"product":"Acyltransferase; enzyme mainly responsible for the introduction of saturated very long chain fatty acids into neo-synthesized molecules of phosphatidylinositol; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR042C"}


id: YBR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"QDR3","product":"Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; involved in spore wall asembly; sequence similarity to DTR1 and QDR1, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin","secondary_identifier":"SGD:S000000247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR043C"}


id: YBR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TCM62","product":"Protein involved in assembly of the succinate dehydrogenase complex; mitochondrial; putative chaperone","secondary_identifier":"SGD:S000000248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR044C"}


id: YBR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GIP1","product":"Meiosis-specific regulatory subunit of the Glc7p protein phosphatase; regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p","secondary_identifier":"SGD:S000000249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR045C"}


id: YBR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03476":null,"YBR046C":null},"has_protein_features":false,"name":"ZTA1","ortholog_annotations":[{"gene_uniquename":"YBR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03476","reference_uniquename":"PMID:29761456"}],"product":"NADPH-dependent quinone reductase; GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR046C"}


id: YBR047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FMP23","product":"Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000000251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR047W"}


id: YBR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00069":null,"SJAG_00503":null,"YBR048W":null},"has_protein_features":false,"name":"RPS11B","ortholog_annotations":[{"gene_uniquename":"YBR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00069","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00503","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR048W"}


id: YBR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00073":null,"SJAG_02922":null,"SJAG_04855":null,"YBR049C":null},"has_protein_features":false,"name":"REB1","ortholog_annotations":[{"gene_uniquename":"YBR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00073","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02922","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04855","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; Reb1p bound to DNA acts to block RNA polymerase II readthrough transcription","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR049C"}


id: YBR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"REG2","product":"Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease; REG2 has a paralog, REG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR050C"}


id: YBR051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase","secondary_identifier":"SGD:S000000255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR051W"}


id: YBR052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02697":null,"YBR052C":null},"has_protein_features":false,"name":"RFS1","ortholog_annotations":[{"gene_uniquename":"YBR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02697","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR052C"}


id: YBR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; induced by cell wall perturbation","secondary_identifier":"SGD:S000000257","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR053C"}


id: YBR054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02533":null,"YBR054W":null},"has_protein_features":false,"name":"YRO2","ortholog_annotations":[{"gene_uniquename":"YBR054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02533","reference_uniquename":"PMID:29761456"}],"product":"Protein with a putative role in response to acid stress; null mutant is sensitive to acetic acid; transcription is regulated by Haa1p and induced in the presence of acetic acid; protein observed in plasma membrane foci in the presence of acetic acid; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000258","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR054W"}


id: YBR055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00643":null,"YBR055C":null},"has_protein_features":false,"name":"PRP6","ortholog_annotations":[{"gene_uniquename":"YBR055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00643","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor; component of the U4/U6-U5 snRNP complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000259","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR055C"}


id: YBR056C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the dubious ORF YBR056W-A","secondary_identifier":"SGD:S000087087","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR056C-B"}


id: YBR056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03646":null,"YBR056W":null},"has_protein_features":false,"name":"MRX18","ortholog_annotations":[{"gene_uniquename":"YBR056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03646","reference_uniquename":"PMID:29761456"}],"product":"Putative glycoside hydrolase of the mitochondrial intermembrane space","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000260","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR056W"}


id: YBR056W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MNC1","product":"Putative membrane protein upregulated in toxic manganese levels; mRNA identified as translated by ribosome profiling data; partially overlaps dubious ORF YBR056C-B; YBR056W-A has a paralog, YDR034W-B, that arose from the whole genome duplication","secondary_identifier":"SGD:S000028736","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR056W-A"}


id: YBR057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MUM2","product":"Protein essential for meiotic DNA replication and sporulation; cytoplasmic protein; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation; also interacts with Orc2p, which is a component of the origin recognition complex","secondary_identifier":"SGD:S000000261","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR057C"}


id: YBR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00644":null,"YBR058C":null},"has_protein_features":false,"name":"UBP14","ortholog_annotations":[{"gene_uniquename":"YBR058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00644","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-specific protease; specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000262","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR058C"}


id: YBR058C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01857":null,"YBR058C-A":null},"has_protein_features":false,"name":"TSC3","ortholog_annotations":[{"gene_uniquename":"YBR058C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01857","reference_uniquename":"PMID:29761456"}],"product":"Protein that stimulates the activity of serine palmitoyltransferase;  involved in sphingolipid biosynthesis; Lcb1p and Lcb2p are the two components of serine palmitoyltransferase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR058C-A"}


id: YBR059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00649":null,"SJAG_04052":null,"SJAG_04465":null,"YBR059C":null},"has_protein_features":false,"name":"AKL1","ortholog_annotations":[{"gene_uniquename":"YBR059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00649","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04052","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04465","reference_uniquename":"PMID:29761456"}],"product":"Ser/Thr protein kinase; phosphorylates Pan1p, Sla1p and Ent1p to negatively regulate endocytosis in response to membrane stress; regulates actin cytoskeleton organization and clathrin-dependent endocytosis; phosphorylated and inhibited by upstream kinase, Fpk1p; member, along with Ark1p and Prk1p, of the Ark kinase family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000263","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR059C"}


id: YBR060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02800":null,"YBR060C":null},"has_protein_features":false,"name":"ORC2","ortholog_annotations":[{"gene_uniquename":"YBR060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02800","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000264","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR060C"}


id: YBR061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01269":null,"YBR061C":null},"has_protein_features":false,"name":"TRM7","ortholog_annotations":[{"gene_uniquename":"YBR061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01269","reference_uniquename":"PMID:29761456"}],"product":"2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively; yeast null mutant can be functionally complemented by human FTSJ1, mutations in which have been implicated in nonsyndromic X-linked intellectual disability (NSXLID)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000265","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR061C"}


id: YBR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01507":null,"SJAG_04915":null,"YBR062C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBR062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01507","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04915","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000266","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR062C"}


id: YBR063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CNM1","product":"Molecular tether on nuclear membrane; mediates contact by interacting with Tom70p on mitochondria; protein abundance is regulated by phosphatidylcholine, enabling coupling of phospholipid homeostasis with contact extent","secondary_identifier":"SGD:S000000267","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR063C"}


id: YBR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR063C","secondary_identifier":"SGD:S000000268","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR064W"}


id: YBR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04117":null,"YBR065C":null},"has_protein_features":false,"name":"ECM2","ortholog_annotations":[{"gene_uniquename":"YBR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04117","reference_uniquename":"PMID:29761456"}],"product":"Pre-mRNA splicing factor; facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000269","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR065C"}


id: YBR066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00124":null,"YBR066C":null},"has_protein_features":false,"name":"NRG2","ortholog_annotations":[{"gene_uniquename":"YBR066C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00124","reference_uniquename":"PMID:26896847"}],"product":"Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; activated in stochastic pulses of nuclear localization in response to low glucose","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000000270","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR066C"}


id: YBR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TIP1","product":"Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins","secondary_identifier":"SGD:S000000271","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR067C"}


id: YBR068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YBR068C":null},"has_protein_features":false,"name":"BAP2","ortholog_annotations":[{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000272","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR068C"}


id: YBR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YBR069C":null},"has_protein_features":false,"name":"TAT1","ortholog_annotations":[{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000273","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR069C"}


id: YBR070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04821":null,"YBR070C":null},"has_protein_features":false,"name":"ALG14","ortholog_annotations":[{"gene_uniquename":"YBR070C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04821","reference_uniquename":"PMID:29761456"}],"product":"Component of UDP-GlcNAc transferase; required for second step of dolichyl-linked oligosaccharide synthesis; anchors catalytic subunit Alg13p to ER membrane; similar to bacterial and human glycosyltransferases; both human homologs ALG13 and ALG14 are required to complement yeast alg14 mutant; mutations of human ALG14 cause congenital myasthenic syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000274","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR070C"}


id: YBR071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking","secondary_identifier":"SGD:S000000275","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR071W"}


id: YBR072C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028532","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR072C-A"}


id: YBR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02919":null,"SJAG_03815":null,"SJAG_04567":null,"YBR072W":null},"has_protein_features":false,"name":"HSP26","ortholog_annotations":[{"gene_uniquename":"YBR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02919","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03815","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04567","reference_uniquename":"PMID:29761456"}],"product":"Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic foci; oligomer activation requires heat-induced conformational change; also has mRNA binding activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000276","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR072W"}


id: YBR073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00980":null,"YBR073W":null},"has_protein_features":false,"name":"RDH54","ortholog_annotations":[{"gene_uniquename":"YBR073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00980","reference_uniquename":"PMID:29761456"}],"product":"DNA-dependent ATPase; DNA recombination/repair translocase, supercoils DNA, promotes DNA strand opening; stimulates strand exchange by modifying dsDNA topology; involved in recombinational repair of DNA double-strand breaks (DSBs) during mitosis, meiosis; implicated in cell divisions in telomerase-negative strains through adaptation to DNA damage, which allows bypass of cell cycle arrest and contributes senescence-specific genome instability; phosphorylated in response to DNA damage","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000277","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR073W"}


id: YBR074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03009":null,"SJAG_04103":null,"YBR074W":null},"has_protein_features":false,"name":"PFF1","ortholog_annotations":[{"gene_uniquename":"YBR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03009","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04103","reference_uniquename":"PMID:29761456"}],"product":"Multi-spanning vacuolar membrane protease; glycosylated transmembrane protein bearing homology to the M28 family of metalloproteases; has a lumenal-facing protease domain; proposed role in vacuole physiology","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000278","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR074W"}


id: YBR075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YBR075W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YBR074W","secondary_identifier":"SGD:S000000279","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR075W"}


id: YBR076C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028533","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR076C-A"}


id: YBR076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05002":null,"YBR076W":null},"has_protein_features":false,"name":"ECM8","ortholog_annotations":[{"gene_uniquename":"YBR076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05002","reference_uniquename":"PMID:29761456"}],"product":"Non-essential protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000280","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR076W"}


id: YBR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03089":null,"YBR077C":null},"has_protein_features":false,"name":"SLM4","ortholog_annotations":[{"gene_uniquename":"YBR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03089","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the EGO/GSE complex; the vacuolar/endosomal membrane associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from the endosome to the plasma membrane; essential for the integrity and function of EGO; gene exhibits synthetic genetic interaction with MSS4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000281","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR077C"}


id: YBR078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00340":null,"SJAG_03483":null,"YBR078W":null},"has_protein_features":false,"name":"ECM33","ortholog_annotations":[{"gene_uniquename":"YBR078W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00340","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR078W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03483","reference_uniquename":"PMID:29761456"}],"product":"GPI-anchored protein involved in efficient glucose uptake; possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p; ECM33 has a paralog, PST1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000282","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR078W"}


id: YBR079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02628":null,"YBR079C":null},"has_protein_features":false,"name":"RPG1","ortholog_annotations":[{"gene_uniquename":"YBR079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02628","reference_uniquename":"PMID:29761456"}],"product":"eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; essential for loading mRNA onto ribosome at entry and exit channels of preinitiation complex; involved in translation reinitiation; eIF3 is also involved in programmed stop codon readthrough","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000283","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR079C"}


id: YBR080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00330":null,"YBR080C":null},"has_protein_features":false,"name":"SEC18","ortholog_annotations":[{"gene_uniquename":"YBR080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00330","reference_uniquename":"PMID:29761456"}],"product":"AAA ATPase and SNARE disassembly chaperone; required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian N-ethylmaleimide-sensitive factor (NSF)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000284","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR080C"}


id: YBR081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02927":null,"YBR081C":null},"has_protein_features":false,"name":"SPT7","ortholog_annotations":[{"gene_uniquename":"YBR081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02927","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SAGA transcriptional regulatory complex; involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000285","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR081C"}


id: YBR082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04573":null,"YBR082C":null},"has_protein_features":false,"name":"UBC4","ortholog_annotations":[{"gene_uniquename":"YBR082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04573","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-conjugating enzyme (E2); key E2 partner with Ubc1p for the anaphase-promoting complex (APC); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000286","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR082C"}


id: YBR083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TEC1","product":"Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member","secondary_identifier":"SGD:S000000287","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR083W"}


id: YBR084C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00384":null,"SJAG_00765":null,"YBR084C-A":null},"has_protein_features":false,"name":"RPL19A","ortholog_annotations":[{"gene_uniquename":"YBR084C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00384","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR084C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00765","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002156","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR084C-A"}


id: YBR084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00106":null,"SJAG_04156":null,"YBR084W":null},"has_protein_features":false,"name":"MIS1","ortholog_annotations":[{"gene_uniquename":"YBR084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00106","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04156","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial C1-tetrahydrofolate synthase; involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000288","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR084W"}


id: YBR085C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000007522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR085C-A"}


id: YBR085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02050":null,"YBR085W":null},"has_protein_features":false,"name":"AAC3","ortholog_annotations":[{"gene_uniquename":"YBR085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02050","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000289","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR085W"}


id: YBR086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01168":null,"YBR086C":null},"has_protein_features":false,"name":"IST2","ortholog_annotations":[{"gene_uniquename":"YBR086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01168","reference_uniquename":"PMID:29761456"}],"product":"Cortical ER protein involved in ER-plasma membrane (PM) tethering; one of 6 proteins (Ist2, Scs2, Scs22, Tcb1, Tcb2, Tcb3) that connect ER to PM, regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1 phosphatase to PI4P; required to locate Osh6, Osh7 in ER/PM contact site to allow phosphatidylserine transport from ER to PM; localizes to mother in small-budded cells, to bud in medium-, large-budded cells; mRNA transported to bud tip by actomyosin-driven process","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000290","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR086C"}


id: YBR087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00272":null,"YBR087W":null},"has_protein_features":false,"name":"RFC5","ortholog_annotations":[{"gene_uniquename":"YBR087W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00272","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000291","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR087W"}


id: YBR088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04190":null,"YBR088C":null},"has_protein_features":false,"name":"POL30","ortholog_annotations":[{"gene_uniquename":"YBR088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04190","reference_uniquename":"PMID:29761456"}],"product":"Proliferating cell nuclear antigen (PCNA); functions as the sliding replication clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair; PCNA ubiquitination at K164 plays a crucial role during Okazaki fragment processing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000292","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR088C"}


id: YBR089C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03603":null,"YBR089C-A":null},"has_protein_features":false,"name":"NHP6B","ortholog_annotations":[{"gene_uniquename":"YBR089C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03603","reference_uniquename":"PMID:29761456"}],"product":"High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002157","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR089C-A"}


id: YBR089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30","secondary_identifier":"SGD:S000000293","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR089W"}


id: YBR090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus","secondary_identifier":"SGD:S000000294","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR090C"}


id: YBR091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00687":null,"YBR091C":null},"has_protein_features":false,"name":"TIM12","ortholog_annotations":[{"gene_uniquename":"YBR091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00687","reference_uniquename":"PMID:29761456"}],"product":"Essential protein of the inner mitochondrial membrane; peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000295","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR091C"}


id: YBR092C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01970":null,"SJAG_04067":null,"YBR092C":null},"has_protein_features":false,"name":"PHO3","ortholog_annotations":[{"gene_uniquename":"YBR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01970","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04067","reference_uniquename":"PMID:29761456"}],"product":"Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000296","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR092C"}


id: YBR093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01970":null,"SJAG_04067":null,"YBR093C":null},"has_protein_features":false,"name":"PHO5","ortholog_annotations":[{"gene_uniquename":"YBR093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01970","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04067","reference_uniquename":"PMID:29761456"}],"product":"Repressible acid phosphatase; 1 of 3 repressible acid phosphatases that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000297","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR093C"}


id: YBR094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01897":null,"YBR094W":null},"has_protein_features":false,"name":"PBY1","ortholog_annotations":[{"gene_uniquename":"YBR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01897","reference_uniquename":"PMID:29761456"}],"product":"Putative tubulin tyrosine ligase associated with P-bodies; may have a role in mRNA metabolism; yeast knockout collection strain identified as a pby1 null mutant is actually wild-type for PBY1 and deleted for mms4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000298","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR094W"}


id: YBR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04576":null,"YBR095C":null},"has_protein_features":false,"name":"RXT2","ortholog_annotations":[{"gene_uniquename":"YBR095C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04576","reference_uniquename":"PMID:29761456"}],"product":"Component of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000299","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR095C"}


id: YBR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER","secondary_identifier":"SGD:S000000300","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR096W"}


id: YBR097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04552":null,"YBR097W":null},"has_protein_features":false,"name":"VPS15","ortholog_annotations":[{"gene_uniquename":"YBR097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04552","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000301","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR097W"}


id: YBR098W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00623":null,"YBR098W":null},"has_protein_features":false,"name":"MMS4","ortholog_annotations":[{"gene_uniquename":"YBR098W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00623","reference_uniquename":"PMID:29761456"}],"product":"Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdc5p during mitotic cell cycle activates the function of Mms4p-Mus81p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000302","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR098W"}


id: YBR099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4","secondary_identifier":"SGD:S000000303","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR099C"}


id: YBR100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YBR100W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YBR098W","secondary_identifier":"SGD:S000000304","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR100W"}


id: YBR101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01556":null,"YBR101C":null},"has_protein_features":false,"name":"FES1","ortholog_annotations":[{"gene_uniquename":"YBR101C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01556","reference_uniquename":"PMID:29761456"}],"product":"Hsp70 (Ssa1p) nucleotide exchange factor; required for the release of misfolded proteins from the Hsp70 system to the Ub-proteasome machinery for degradation; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000305","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR101C"}


id: YBR102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03357":null,"YBR102C":null},"has_protein_features":false,"name":"EXO84","ortholog_annotations":[{"gene_uniquename":"YBR102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03357","reference_uniquename":"PMID:29761456"}],"product":"Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000306","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR102C"}


id: YBR103C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by homology to related yeast","secondary_identifier":"SGD:S000007593","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR103C-A"}


id: YBR103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01926":null,"YBR103W":null},"has_protein_features":false,"name":"SIF2","ortholog_annotations":[{"gene_uniquename":"YBR103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01926","reference_uniquename":"PMID:29761456"}],"product":"WD40 repeat-containing subunit of Set3C histone deacetylase complex; complex represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000307","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR103W"}


id: YBR104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00626":null,"YBR104W":null},"has_protein_features":false,"name":"YMC2","ortholog_annotations":[{"gene_uniquename":"YBR104W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00626","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000308","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR104W"}


id: YBR105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03385":null,"YBR105C":null},"has_protein_features":false,"name":"VID24","ortholog_annotations":[{"gene_uniquename":"YBR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03385","reference_uniquename":"PMID:29761456"}],"product":"GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000309","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR105C"}


id: YBR106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00603":null,"SJAG_01782":null,"YBR106W":null},"has_protein_features":false,"name":"SND3","ortholog_annotations":[{"gene_uniquename":"YBR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00603","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01782","reference_uniquename":"PMID:29761456"}],"product":"Involved in SRP-independent protein targeting to the ER; component of an alternative ER-targeting pathway partially redundant with the GET pathway that can compensate for SRP loss; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Env10p/Snd2p, and Sec61p-translocon subunits; role in establishing nucleus-vacuole junctions (NVJs) in high glucose; targeted to the NVJ during glucose starvation to facilitate expansion; role in phosphate transport with Pho86p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000310","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR106W"}


id: YBR107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01278":null,"YBR107C":null},"has_protein_features":false,"name":"IML3","ortholog_annotations":[{"gene_uniquename":"YBR107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01278","reference_uniquename":"PMID:29761456"}],"product":"Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; forms a stable complex with Chl4p; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000311","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR107C"}


id: YBR108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AIM3","product":"Protein that inhibits barbed-end actin filament elongation; interacts with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss","secondary_identifier":"SGD:S000000312","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR108W"}


id: YBR109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04781":null,"SJAG_04901":null,"YBR109C":null},"has_protein_features":false,"name":"CMD1","ortholog_annotations":[{"gene_uniquename":"YBR109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04781","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YBR109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04901","reference_uniquename":"PMID:29761456"}],"product":"Calmodulin; Ca2+ binding protein that regulates Ca2+ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca2+ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin; binds to the Hog1p MAPK in response to hyperosmotic stress; potentiates membrane tubulation and constriction mediated by the Rvs161p-Rvs167p complex; human CALM1 or CALM2 functionally complement repression induced inviability","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000313","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR109C"}


id: YBR109W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; questionable ORF from MIPS","secondary_identifier":"SGD:S000028737","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR109W-A"}


id: YBR110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02102":null,"YBR110W":null},"has_protein_features":false,"name":"ALG1","ortholog_annotations":[{"gene_uniquename":"YBR110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02102","reference_uniquename":"PMID:29761456"}],"product":"Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability; human homolog ALG1 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000314","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR110W"}


id: YBR111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03977":null,"YBR111C":null},"has_protein_features":false,"name":"YSA1","ortholog_annotations":[{"gene_uniquename":"YBR111C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03977","reference_uniquename":"PMID:29761456"}],"product":"Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000315","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR111C"}


id: YBR111W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00641":null,"YBR111W-A":null},"has_protein_features":false,"name":"SUS1","ortholog_annotations":[{"gene_uniquename":"YBR111W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00641","reference_uniquename":"PMID:29761456"}],"product":"Global transcriptional regulator, component of SAGA, TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to nuclear periphery and to non-nascent mRNP; plays role in negatively regulating telomere length through modulation of H2BK123 mono-ubiquitination and its interaction with nuclear pore complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028510","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR111W-A"}


id: YBR112C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00861":null,"YBR112C":null},"has_protein_features":false,"name":"CYC8","ortholog_annotations":[{"gene_uniquename":"YBR112C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00861","reference_uniquename":"PMID:29761456"}],"product":"General transcriptional co-repressor; acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+]","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000316","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR112C"}


id: YBR113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8","secondary_identifier":"SGD:S000000317","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR113W"}


id: YBR114W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00500":null,"SJAG_03613":null,"SJAG_04147":null,"YBR114W":null},"has_protein_features":false,"name":"RAD16","ortholog_annotations":[{"gene_uniquename":"YBR114W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00500","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR114W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03613","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR114W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04147","reference_uniquename":"PMID:29761456"}],"product":"Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad7p) during NER; required for NER of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000318","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR114W"}


id: YBR115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00869":null,"YBR115C":null},"has_protein_features":false,"name":"LYS2","ortholog_annotations":[{"gene_uniquename":"YBR115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00869","reference_uniquename":"PMID:29761456"}],"product":"Alpha aminoadipate reductase; catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000319","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR115C"}


id: YBR116C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2","secondary_identifier":"SGD:S000000320","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR116C"}


id: YBR117C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03934":null,"YBR117C":null},"has_protein_features":false,"name":"TKL2","ortholog_annotations":[{"gene_uniquename":"YBR117C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03934","reference_uniquename":"PMID:29761456"}],"product":"Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL2 has a paralog, TKL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000321","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR117C"}


id: YBR118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01851":null,"SJAG_02180":null,"SJAG_04157":null,"YBR118W":null},"has_protein_features":false,"name":"TEF2","ortholog_annotations":[{"gene_uniquename":"YBR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01851","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02180","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04157","reference_uniquename":"PMID:29761456"}],"product":"Translational elongation factor EF-1 alpha; GTP-bound active form, binds to and delivers aminoacylated tRNA to the A-site of ribosomes for elongation of nascent polypeptides; moonlighting function as an actin binding and bundling protein; association with GTPase Rho1p on the vacuolar membrane may facilitate F-actin remodeling; involved in tRNA re-export from the nucleus; Tef2p-RFP levels increase during replicative aging","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000322","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR118W"}


id: YBR119W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04911":null,"YBR119W":null},"has_protein_features":false,"name":"MUD1","ortholog_annotations":[{"gene_uniquename":"YBR119W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04911","reference_uniquename":"PMID:29761456"}],"product":"U1 snRNP A protein; homolog of human U1-A; involved in nuclear mRNA splicing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000323","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR119W"}


id: YBR120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04560":null,"YBR120C":null},"has_protein_features":false,"name":"CBP6","ortholog_annotations":[{"gene_uniquename":"YBR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04560","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000324","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR120C"}


id: YBR121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01352":null,"YBR121C":null},"has_protein_features":false,"name":"GRS1","ortholog_annotations":[{"gene_uniquename":"YBR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01352","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication; human homolog GARS implicated in Charcot-Marie-Tooth disease, can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000325","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR121C"}


id: YBR121C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely contained within the verified gene GRS1; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028815","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR121C-A"}


id: YBR122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05573":null,"YBR122C":null},"has_protein_features":false,"name":"MRPL36","ortholog_annotations":[{"gene_uniquename":"YBR122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05573","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000326","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR122C"}


id: YBR123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03354":null,"YBR123C":null},"has_protein_features":false,"name":"TFC1","ortholog_annotations":[{"gene_uniquename":"YBR123C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03354","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000327","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR123C"}


id: YBR124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000000328","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR124W"}


id: YBR125C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PTC4","product":"Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity","secondary_identifier":"SGD:S000000329","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR125C"}


id: YBR126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01531":null,"YBR126C":null},"has_protein_features":false,"name":"TPS1","ortholog_annotations":[{"gene_uniquename":"YBR126C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01531","reference_uniquename":"PMID:29761456"}],"product":"Synthase subunit of trehalose-6-P synthase/phosphatase complex; synthesizes the storage carbohydrate trehalose, which is critically important for survival of long-term desiccation; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000330","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR126C"}


id: YBR126W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MEO1","product":"Putative protein of unknown function; identified by gene-trapping, microarray analysis, and genome-wide homology searches; mRNA identified as translated by ribosome profiling data; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; partially overlaps the dubious ORF YBR126W-B","secondary_identifier":"SGD:S000028600","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR126W-A"}


id: YBR126W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-A; identified by SAGE","secondary_identifier":"SGD:S000028738","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR126W-B"}


id: YBR127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00136":null,"YBR127C":null},"has_protein_features":false,"name":"VMA2","ortholog_annotations":[{"gene_uniquename":"YBR127C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00136","reference_uniquename":"PMID:29761456"}],"product":"Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase; electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm; protein abundance increases in response to DNA replication stress; human homolog ATP6V1B1, implicated in autosomal-recessive distal renal tubular acidosis (RTA) with sensorineural deafness, complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000331","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR127C"}


id: YBR128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02699":null,"YBR128C":null},"has_protein_features":false,"name":"ATG14","ortholog_annotations":[{"gene_uniquename":"YBR128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02699","reference_uniquename":"PMID:29761456"}],"product":"Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I; Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor; other members are Vps34, Vps15, and Vps30p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000332","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR128C"}


id: YBR129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02657":null,"YBR129C":null},"has_protein_features":false,"name":"OPY1","ortholog_annotations":[{"gene_uniquename":"YBR129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02657","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000333","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR129C"}


id: YBR130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SHE3","product":"Protein adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance","secondary_identifier":"SGD:S000000334","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR130C"}


id: YBR131C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR131W; identified by gene-trapping, microarray analysis, and genome-wide homology searches","secondary_identifier":"SGD:S000028601","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR131C-A"}


id: YBR131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CCZ1","product":"Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex, which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; involved in localizing Ypt7p to the vacuolar membrane; required for macroautophagy, the CVT pathway and mitophagy","secondary_identifier":"SGD:S000000335","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR131W"}


id: YBR132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02955":null,"YBR132C":null},"has_protein_features":false,"name":"AGP2","ortholog_annotations":[{"gene_uniquename":"YBR132C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02955","reference_uniquename":"PMID:26896847"}],"product":"Plasma membrane regulator of polyamine and carnitine transport; has similarity to transporters but lacks transport activity; may act as a sensor that transduces environmental signals; has a positive or negative regulatory effect on transcription of many transporter genes","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000000336","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR132C"}


id: YBR133C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00596":null,"YBR133C":null},"has_protein_features":false,"name":"HSL7","ortholog_annotations":[{"gene_uniquename":"YBR133C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00596","reference_uniquename":"PMID:29761456"}],"product":"Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent localization to the bud neck in budded cells and periodic Hsl1p-dependent phosphorylation; required with Hsl1p, and Elm1p for the mother-bud neck recruitment, phosphorylation, and degradation of Swe1p; responsible for symmetric dimethylation of histone H4 on Arg3; relocalizes away from bud neck upon DNA replication stress; human homolog PRMT5 can complement yeast hsl7 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000337","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR133C"}


id: YBR134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000338","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR134W"}


id: YBR135W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00439":null,"YBR135W":null},"has_protein_features":false,"name":"CKS1","ortholog_annotations":[{"gene_uniquename":"YBR135W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00439","reference_uniquename":"PMID:29761456"}],"product":"Cyclin-dependent protein kinase regulatory subunit and adaptor; interacts with Cdc28p (aka Cdk1p); required for G1/S and G2/M phase transitions and budding; mediates phosphorylation and degradation of Sic1p; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters; human homologs CKS1B and CKS2 can each complement yeast cks1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000339","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR135W"}


id: YBR136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00364":null,"YBR136W":null},"has_protein_features":false,"name":"MEC1","ortholog_annotations":[{"gene_uniquename":"YBR136W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00364","reference_uniquename":"PMID:29761456"}],"product":"Genome integrity checkpoint protein and PI kinase superfamily member; Mec1p and Dun1p function in same pathway to regulate dNTP pools and telomere length; signal transducer required for cell cycle arrest and transcriptional responses to damaged or unreplicated DNA; facilitates replication fork progression and regulates P-body formation under replication stress; promotes interhomolog recombination by phosphorylating Hop1p; associates with shortened, dysfunctional telomeres","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000340","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR136W"}


id: YBR137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein with a role in ER delivery of tail-anchored membrane proteins; interacts with Sgt2p; binds to the TRC complex, which inserts proteins into the ER membrane; interacts with Msn5p karyopherin; YBR137W is not an essential gene","secondary_identifier":"SGD:S000000341","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR137W"}


id: YBR138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Cytoplasmic protein of unknown function; APCC(Cdh1) substrate; potentially phosphorylated by Cdc28p; YBR138C is not an essential gene","secondary_identifier":"SGD:S000000342","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR138C"}


id: YBR139W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01868":null,"YBR139W":null},"has_protein_features":false,"name":"ATG42","ortholog_annotations":[{"gene_uniquename":"YBR139W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01868","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar serine-type carboxypeptidase; involved, along with functional homolog Prc1p, in vacuolar zymogen activation, breakdown of the autophagic body, and autophagosome-dependent protein synthesis; role in phytochelatin synthesis; localizes to the vacuole lumen; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner; N-glycosylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000343","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR139W"}


id: YBR140C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IRA1","product":"GTPase-activating protein; negatively regulates RAS by converting it from GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog, IRA2, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis","secondary_identifier":"SGD:S000000344","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR140C"}


id: YBR141C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03016":null,"YBR141C":null},"has_protein_features":false,"name":"BMT2","ortholog_annotations":[{"gene_uniquename":"YBR141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03016","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of large subunit (LSU) rRNA at position 2142; belongs to Rossmann fold superfamily; null mutant exhibits abnormal lipid metabolic phenotype; not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000345","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR141C"}


id: YBR141W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YBR141C; identified by gene-trapping, microarray analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028602","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR141W-A"}


id: YBR142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02835":null,"YBR142W":null},"has_protein_features":false,"name":"MAK5","ortholog_annotations":[{"gene_uniquename":"YBR142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02835","reference_uniquename":"PMID:29761456"}],"product":"Essential nucleolar protein; putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000346","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR142W"}


id: YBR143C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00338":null,"YBR143C":null},"has_protein_features":false,"name":"SUP45","ortholog_annotations":[{"gene_uniquename":"YBR143C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00338","reference_uniquename":"PMID:29761456"}],"product":"Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000347","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR143C"}


id: YBR144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; YBR144C is not an essential gene","secondary_identifier":"SGD:S000000348","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR144C"}


id: YBR145W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01414":null,"SJAG_03370":null,"YBR145W":null},"has_protein_features":false,"name":"ADH5","ortholog_annotations":[{"gene_uniquename":"YBR145W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01414","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR145W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03370","reference_uniquename":"PMID:29761456"}],"product":"Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000349","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR145W"}


id: YBR146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04753":null,"YBR146W":null},"has_protein_features":false,"name":"MRPS9","ortholog_annotations":[{"gene_uniquename":"YBR146W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04753","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000350","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR146W"}


id: YBR147W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00051":null,"SJAG_04787":null,"YBR147W":null},"has_protein_features":false,"name":"RTC2","ortholog_annotations":[{"gene_uniquename":"YBR147W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00051","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR147W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04787","reference_uniquename":"PMID:29761456"}],"product":"Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000351","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR147W"}


id: YBR148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YSW1","product":"Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane; YSW1 has a paralog, SPO21, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000352","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR148W"}


id: YBR149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ARA1","product":"NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product","secondary_identifier":"SGD:S000000353","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR149W"}


id: YBR150C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TBS1","product":"Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; associates with rDNA chromatin in vivo; TBS1 has a paralog, HAL9, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000354","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR150C"}


id: YBR151W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"APD1","product":"2Fe-2S cytosolic protein of unknown function; bishistidinyl coordinated, non-Rieske [2Fe-2S] cluster containing thiredoxin-like ferredoxin; required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm; homologous to AIM32","secondary_identifier":"SGD:S000000355","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR151W"}


id: YBR152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00076":null,"YBR152W":null},"has_protein_features":false,"name":"SPP381","ortholog_annotations":[{"gene_uniquename":"YBR152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00076","reference_uniquename":"PMID:29761456"}],"product":"mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p; relocalizes to the cytosol in response to hypoxia; temperature-sensitive phenotype of prp38-1 mutant can be suppressed by human homolog of SPP381, MFAP1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000356","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR152W"}


id: YBR153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00491":null,"YBR153W":null},"has_protein_features":false,"name":"RIB7","ortholog_annotations":[{"gene_uniquename":"YBR153W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00491","reference_uniquename":"PMID:29761456"}],"product":"Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000357","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR153W"}


id: YBR154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02101":null,"YBR154C":null},"has_protein_features":false,"name":"RPB5","ortholog_annotations":[{"gene_uniquename":"YBR154C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02101","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000358","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR154C"}


id: YBR155W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01914":null,"YBR155W":null},"has_protein_features":false,"name":"CNS1","ortholog_annotations":[{"gene_uniquename":"YBR155W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01914","reference_uniquename":"PMID:29761456"}],"product":"TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70); stimulates ATPase activity of Ssa1p; ts mutants reduce Hsp82p function, overexpression suppresses phenotypes of HSP82 ts allele and cpr7 deletion; human homolog TTC4 complements yeast cns1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000359","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR155W"}


id: YBR156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02807":null,"YBR156C":null},"has_protein_features":false,"name":"SLI15","ortholog_annotations":[{"gene_uniquename":"YBR156C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02807","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the conserved chromosomal passenger complex (CPC); complex regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; other complex members are Ipl1p, Bir1p, and Nbl1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000360","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR156C"}


id: YBR157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ICS2","product":"Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization","secondary_identifier":"SGD:S000000361","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR157C"}


id: YBR158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AMN1","product":"Modulator of cell separation and mitotic exit; inhibits separation through Ub-dependent Ace2p proteolysis; part of a daughter-specific switch induced by the mitotic exit network that inhibits exit and resets the cell cycle after the execution of  MEN function, blocking Tem1p and Cdc15 association; required for chromosome stability and multiple mitotic checkpoints; regulated by SCF; haploid transcription regulated by Ste12p; contains 12 degenerate leucine-rich repeat motifs and an atypical F-box","secondary_identifier":"SGD:S000000362","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR158W"}


id: YBR159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00630":null,"YBR159W":null},"has_protein_features":false,"name":"IFA38","ortholog_annotations":[{"gene_uniquename":"YBR159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00630","reference_uniquename":"PMID:29761456"}],"product":"Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000363","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR159W"}


id: YBR160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03048":null,"YBR160W":null},"has_protein_features":false,"name":"CDC28","ortholog_annotations":[{"gene_uniquename":"YBR160W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03048","reference_uniquename":"PMID:29761456"}],"product":"Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1, S, G2/M phase cyclins, which provide substrate specificity; regulates metabolism, basal transcription, chromosome dynamics, growth and morphogenesis; transcript induction in osmostress involves antisense RNA; human homologs CDK1, CDK2, CDK3 can complement yeast conditional cdc28 mutants; human CDK1, CDK2 can complement yeast cdc28 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000364","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR160W"}


id: YBR161W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02168":null,"SJAG_03953":null,"YBR161W":null},"has_protein_features":false,"name":"CSH1","ortholog_annotations":[{"gene_uniquename":"YBR161W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02168","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR161W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03953","reference_uniquename":"PMID:29761456"}],"product":"Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000365","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR161W"}


id: YBR162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00876":null,"YBR162C":null},"has_protein_features":false,"name":"TOS1","ortholog_annotations":[{"gene_uniquename":"YBR162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00876","reference_uniquename":"PMID:29761456"}],"product":"Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000366","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR162C"}


id: YBR162W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03611":null,"YBR162W-A":null},"has_protein_features":false,"name":"YSY6","ortholog_annotations":[{"gene_uniquename":"YBR162W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03611","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002158","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR162W-A"}


id: YBR163W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05280":null,"YBR163W":null},"has_protein_features":false,"name":"EXO5","ortholog_annotations":[{"gene_uniquename":"YBR163W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05280","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial 5'-3' exonuclease and sliding exonuclease; required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000367","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR163W"}


id: YBR164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ARL1","product":"Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; role in membrane organization at trans-Golgi network; required for delivery of Atg9p to the phagophore assembly site during autophagy under high temperature stress; required with Ypt6p for starvation-induced autophagy; required for the CVT pathway under non-starvation conditions; G protein of the Ras superfamily, similar to ADP-ribosylation factor","secondary_identifier":"SGD:S000000368","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR164C"}


id: YBR165W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"UBS1","product":"Ubiquitin-conjugating enzyme suppressor that regulates Cdc34p; functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity","secondary_identifier":"SGD:S000000369","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR165W"}


id: YBR166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04652":null,"YBR166C":null},"has_protein_features":false,"name":"TYR1","ortholog_annotations":[{"gene_uniquename":"YBR166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04652","reference_uniquename":"PMID:29761456"}],"product":"Prephenate dehydrogenase involved in tyrosine biosynthesis; expression is dependent on phenylalanine levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000370","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR166C"}


id: YBR167C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01369":null,"SJAG_06613":null,"YBR167C":null},"has_protein_features":false,"name":"POP7","ortholog_annotations":[{"gene_uniquename":"YBR167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01369","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06613","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop6p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000371","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR167C"}


id: YBR168W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01685":null,"YBR168W":null},"has_protein_features":false,"name":"PEX32","ortholog_annotations":[{"gene_uniquename":"YBR168W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01685","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000372","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR168W"}


id: YBR169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04511":null,"YBR169C":null},"has_protein_features":false,"name":"SSE2","ortholog_annotations":[{"gene_uniquename":"YBR169C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04511","reference_uniquename":"PMID:29761456"}],"product":"Member of Hsp110 subclass of the heat shock protein 70 (HSP70) family; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000373","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR169C"}


id: YBR170C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01134":null,"YBR170C":null},"has_protein_features":false,"name":"NPL4","ortholog_annotations":[{"gene_uniquename":"YBR170C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01134","reference_uniquename":"PMID:29761456"}],"product":"Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000374","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR170C"}


id: YBR171W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02354":null,"YBR171W":null},"has_protein_features":false,"name":"SEC66","ortholog_annotations":[{"gene_uniquename":"YBR171W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02354","reference_uniquename":"PMID:29761456"}],"product":"Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and translocation into the ER; other members are Sec63p, Sec62p, and Sec72p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000375","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR171W"}


id: YBR172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01279":null,"YBR172C":null},"has_protein_features":false,"name":"SMY2","ortholog_annotations":[{"gene_uniquename":"YBR172C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01279","reference_uniquename":"PMID:29761456"}],"product":"GYF domain protein; involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000376","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR172C"}


id: YBR173C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04290":null,"YBR173C":null},"has_protein_features":false,"name":"UMP1","ortholog_annotations":[{"gene_uniquename":"YBR173C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04290","reference_uniquename":"PMID:29761456"}],"product":"Chaperone required for correct maturation of the 20S proteasome; short-lived chaperone; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000377","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR173C"}


id: YBR174C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective","secondary_identifier":"SGD:S000000378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR174C"}


id: YBR175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02329":null,"YBR175W":null},"has_protein_features":false,"name":"SWD3","ortholog_annotations":[{"gene_uniquename":"YBR175W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02329","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR175W"}


id: YBR176W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05200":null,"YBR176W":null},"has_protein_features":false,"name":"ECM31","ortholog_annotations":[{"gene_uniquename":"YBR176W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05200","reference_uniquename":"PMID:29761456"}],"product":"Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR176W"}


id: YBR177C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"EHT1","product":"Octanoyl-CoA:ethanol acyltransferase; also functions as thioesterase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR177C"}


id: YBR178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C","secondary_identifier":"SGD:S000000382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR178W"}


id: YBR179C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00031":null,"YBR179C":null},"has_protein_features":false,"name":"FZO1","ortholog_annotations":[{"gene_uniquename":"YBR179C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00031","reference_uniquename":"PMID:29761456"}],"product":"Mitofusin, protein involved in mitochondrial outer membrane fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system; activity regulated by ubiquitylation at conserved lysine residues and by  deubiquitylases Ubp2p and Ubp12p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000383","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR179C"}


id: YBR180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DTR1","product":"Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; sequence similarity to QDR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expressed during sporulation","secondary_identifier":"SGD:S000000384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR180W"}


id: YBR181C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03034":null,"SJAG_03859":null,"YBR181C":null},"has_protein_features":false,"name":"RPS6B","ortholog_annotations":[{"gene_uniquename":"YBR181C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR181C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03859","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR181C"}


id: YBR182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02218":null,"SJAG_04191":null,"YBR182C":null},"has_protein_features":false,"name":"SMP1","ortholog_annotations":[{"gene_uniquename":"YBR182C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02218","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YBR182C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04191","reference_uniquename":"PMID:29761456"}],"product":"MADS-box transcription factor involved in osmotic stress response; SMP1 has a paralog, RLM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR182C"}


id: YBR182C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028603","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR182C-A"}


id: YBR183W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YPC1","product":"Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR183W"}


id: YBR184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YBR184W is not an essential gene","secondary_identifier":"SGD:S000000388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR184W"}


id: YBR185C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01917":null,"YBR185C":null},"has_protein_features":false,"name":"MBA1","ortholog_annotations":[{"gene_uniquename":"YBR185C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01917","reference_uniquename":"PMID:29761456"}],"product":"Membrane-associated mitoribosome receptor; involved along with Dpi29p in the cotranslational insertion of nascent polypeptide chains into the inner mitochondrial membrane; associates with nascent polypeptide chains; interacts with Mdm38p and may recruit mRNA-specific translational activators to the mitoribosome; null mutant displays decreased tolerance to mistranslation-induced proteotoxic stress; localizes to the inner mitochondrial membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR185C"}


id: YBR186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PCH2","product":"Hexameric ring ATPase that remodels chromosome axis protein Hop1p; nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in rDNA; required for meiotic double-stranded break formation","secondary_identifier":"SGD:S000000390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR186W"}


id: YBR187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04096":null,"YBR187W":null},"has_protein_features":false,"name":"GDT1","ortholog_annotations":[{"gene_uniquename":"YBR187W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04096","reference_uniquename":"PMID:29761456"}],"product":"Calcium and manganese transporter with higher affinity for Ca2+; involved in Ca2+ and Mn2+ homeostasis; localizes to the cis- and medial-Golgi apparatus; GFP-fusion localizes to the vacuole; required for the Mn2+-dependent function of glycosylation enzymes; TMEM165, a human ortholog linked to Congenital Disorders of Glycosylation, functionally complements the null allele; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; expression regulated by Gcr1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR187W"}


id: YBR188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NTC20","product":"Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs","secondary_identifier":"SGD:S000000392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR188C"}


id: YBR189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00544":null,"SJAG_04342":null,"YBR189W":null},"has_protein_features":false,"name":"RPS9B","ortholog_annotations":[{"gene_uniquename":"YBR189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00544","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04342","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR189W"}


id: YBR190W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W","secondary_identifier":"SGD:S000000394","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR190W"}


id: YBR191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00155":null,"SJAG_01202":null,"YBR191W":null},"has_protein_features":false,"name":"RPL21A","ortholog_annotations":[{"gene_uniquename":"YBR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00155","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01202","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000395","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR191W"}


id: YBR191W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007594","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR191W-A"}


id: YBR192W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00154":null,"YBR192W":null},"has_protein_features":false,"name":"RIM2","ortholog_annotations":[{"gene_uniquename":"YBR192W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00154","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000396","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR192W"}


id: YBR193C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03622":null,"YBR193C":null},"has_protein_features":false,"name":"MED8","ortholog_annotations":[{"gene_uniquename":"YBR193C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03622","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000397","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR193C"}


id: YBR194W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00363":null,"YBR194W":null},"has_protein_features":false,"name":"AIM4","ortholog_annotations":[{"gene_uniquename":"YBR194W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00363","reference_uniquename":"PMID:29761456"}],"product":"Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000398","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR194W"}


id: YBR195C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01122":null,"SJAG_02439":null,"YBR195C":null},"has_protein_features":false,"name":"MSI1","ortholog_annotations":[{"gene_uniquename":"YBR195C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01122","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YBR195C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02439","reference_uniquename":"PMID:29761456"}],"product":"Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 affects multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription; Msi1p localizes to nucleus and cytoplasm and independently regulates the RAS/cAMP pathway via sequestration of Npr1p kinase","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000399","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR195C"}


id: YBR196C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00839":null,"YBR196C":null},"has_protein_features":false,"name":"PGI1","ortholog_annotations":[{"gene_uniquename":"YBR196C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00839","reference_uniquename":"PMID:29761456"}],"product":"Glycolytic enzyme phosphoglucose isomerase; catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000400","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR196C"}


id: YBR196C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR; ORF emerged de novo in thymine-rich ancestral non-genic region, accumulated substantial changes under positive selection, and progressively increased its transmembrane propensity to give rise to a protein that integrates into the endoplasmic reticulum (ER) membrane while retaining potential for adaptive change","secondary_identifier":"SGD:S000028534","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR196C-A"}


id: YBR196C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028816","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR196C-B"}


id: YBR197C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000401","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR197C"}


id: YBR198C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02541":null,"YBR198C":null},"has_protein_features":false,"name":"TAF5","ortholog_annotations":[{"gene_uniquename":"YBR198C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02541","reference_uniquename":"PMID:29761456"}],"product":"Subunit (90 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000402","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR198C"}


id: YBR199W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"YBR199W":null},"has_protein_features":false,"name":"KTR4","ortholog_annotations":[{"gene_uniquename":"YBR199W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR199W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR199W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"}],"product":"Glycosyltransferase involved in protein glycosylation; transfers GDP-mannose to methyl-alpha-mannoside in vitro; member of the KRE2/MNT1 mannosyltransferase family of type II membrane proteins with a short cytoplasmic N-terminus, a membrane-spanning region and a highly conserved catalytic lumenal domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000403","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR199W"}


id: YBR200W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01794":null,"YBR200W":null},"has_protein_features":false,"name":"BEM1","ortholog_annotations":[{"gene_uniquename":"YBR200W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01794","reference_uniquename":"PMID:29761456"}],"product":"Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000404","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR200W"}


id: YBR200W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028535","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR200W-A"}


id: YBR201C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MIN7","product":"Mitochondrial protein of unknown function","secondary_identifier":"SGD:S000087085","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR201C-A"}


id: YBR201W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00681":null,"SJAG_03841":null,"YBR201W":null},"has_protein_features":false,"name":"DER1","ortholog_annotations":[{"gene_uniquename":"YBR201W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00681","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR201W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03841","reference_uniquename":"PMID:29761456"}],"product":"ER membrane protein that promotes export of misfolded polypeptides; required for ER-associated protein degradation of misfolded or unassembled proteins; initiates export of aberrant polypeptides from ER lumen by threading them into ER membrane and routing them to Hrd1p for ubiquitination; function normally requires N-terminal acetylation by NatB; N- and C- termini protrude into cytoplasm; similar to Dfm1p; homolog of mammalian derlin-1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000405","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR201W"}


id: YBR202W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00884":null,"YBR202W":null},"has_protein_features":false,"name":"MCM7","ortholog_annotations":[{"gene_uniquename":"YBR202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00884","reference_uniquename":"PMID:29761456"}],"product":"Component of the Mcm2-7 hexameric helicase complex; MCM2-7 primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000406","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR202W"}


id: YBR203W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COS111","product":"Protein required for antifungal drug ciclopirox olamine resistance; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000000407","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR203W"}


id: YBR204C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03604":null,"YBR204C":null},"has_protein_features":false,"name":"LDH1","ortholog_annotations":[{"gene_uniquename":"YBR204C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03604","reference_uniquename":"PMID:29761456"}],"product":"Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000408","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR204C"}


id: YBR205W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"YBR205W":null},"has_protein_features":false,"name":"KTR3","ortholog_annotations":[{"gene_uniquename":"YBR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"}],"product":"Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000409","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR205W"}


id: YBR206W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3","secondary_identifier":"SGD:S000000410","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR206W"}


id: YBR207W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04675":null,"YBR207W":null},"has_protein_features":false,"name":"FTH1","ortholog_annotations":[{"gene_uniquename":"YBR207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04675","reference_uniquename":"PMID:29761456"}],"product":"Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000411","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR207W"}


id: YBR208C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DUR12","product":"Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000000412","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR208C"}


id: YBR209W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; YBR209W is not an essential gene","secondary_identifier":"SGD:S000000413","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR209W"}


id: YBR210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02264":null,"SJAG_04740":null,"YBR210W":null},"has_protein_features":false,"name":"ERV15","ortholog_annotations":[{"gene_uniquename":"YBR210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02264","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04740","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000414","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR210W"}


id: YBR211C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03619":null,"YBR211C":null},"has_protein_features":false,"name":"AME1","ortholog_annotations":[{"gene_uniquename":"YBR211C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03619","reference_uniquename":"PMID:29761456"}],"product":"Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000415","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR211C"}


id: YBR212W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00474":null,"SJAG_02573":null,"YBR212W":null},"has_protein_features":false,"name":"NGR1","ortholog_annotations":[{"gene_uniquename":"YBR212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00474","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YBR212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02573","reference_uniquename":"PMID:29761456"}],"product":"RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000416","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR212W"}


id: YBR213W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01786":null,"YBR213W":null},"has_protein_features":false,"name":"MET8","ortholog_annotations":[{"gene_uniquename":"YBR213W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01786","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional dehydrogenase and ferrochelatase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000417","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR213W"}


id: YBR214W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02380":null,"YBR214W":null},"has_protein_features":false,"name":"SDS24","ortholog_annotations":[{"gene_uniquename":"YBR214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02380","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000418","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR214W"}


id: YBR215W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04561":null,"YBR215W":null},"has_protein_features":false,"name":"HPC2","ortholog_annotations":[{"gene_uniquename":"YBR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04561","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000419","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR215W"}


id: YBR216C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02485":null,"YBR216C":null},"has_protein_features":false,"name":"YBP1","ortholog_annotations":[{"gene_uniquename":"YBR216C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02485","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000420","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR216C"}


id: YBR217W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06309":null,"YBR217W":null},"has_protein_features":false,"name":"ATG12","ortholog_annotations":[{"gene_uniquename":"YBR217W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06309","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-like modifier involved in autophagy and the Cvt pathway; conserved; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; homolog of mammalian ULK1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR217W"}


id: YBR218C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00464":null,"YBR218C":null},"has_protein_features":false,"name":"PYC2","ortholog_annotations":[{"gene_uniquename":"YBR218C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00464","reference_uniquename":"PMID:29761456"}],"product":"Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR218C"}


id: YBR219C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YBR219C is not an essential gene","secondary_identifier":"SGD:S000000423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR219C"}


id: YBR220C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04325":null,"YBR220C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBR220C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04325","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; YBR220C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000424","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR220C"}


id: YBR221C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03064":null,"YBR221C":null},"has_protein_features":false,"name":"PDB1","ortholog_annotations":[{"gene_uniquename":"YBR221C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03064","reference_uniquename":"PMID:29761456"}],"product":"E1 beta subunit of the pyruvate dehydrogenase (PDH) complex; PDH is an evolutionarily conserved multi-protein complex found in mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR221C"}


id: YBR221W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028817","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR221W-A"}


id: YBR222C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00947":null,"YBR222C":null},"has_protein_features":false,"name":"PCS60","ortholog_annotations":[{"gene_uniquename":"YBR222C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00947","reference_uniquename":"PMID:29761456"}],"product":"Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of oxalate; peroxisomal protein that binds mRNA; localizes to both peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid; similar to E. coli long chain acyl-CoA synthetase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000426","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR222C"}


id: YBR223C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04418":null,"YBR223C":null},"has_protein_features":false,"name":"TDP1","ortholog_annotations":[{"gene_uniquename":"YBR223C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04418","reference_uniquename":"PMID:29761456"}],"product":"Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topo I and topo II; mutations in the human homolog, TDP1, result in the a neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy (SCAN1); yeast cells and human rhabdomyosarcoma lines that overexpress TDP1 both exhibit elevated dosage chromosomal instability (dCIN)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000427","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR223C"}


id: YBR223W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps YBR223C; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028604","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR223W-A"}


id: YBR224W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1","secondary_identifier":"SGD:S000000428","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR224W"}


id: YBR225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components","secondary_identifier":"SGD:S000000429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR225W"}


id: YBR226C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W","secondary_identifier":"SGD:S000000430","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR226C"}


id: YBR227C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MCX1","product":"Non-proteolytic ATPase of the AAA family; stimulates incorporation of the pyridoxal phosphate cofactor into Hem1p (5-aminolevulinic acid synthase); localized to the mitochondrial matrix; ortholog of vertebrate CLPX, which promotes erythropoiesis","secondary_identifier":"SGD:S000000431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR227C"}


id: YBR228W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05237":null,"YBR228W":null},"has_protein_features":false,"name":"SLX1","ortholog_annotations":[{"gene_uniquename":"YBR228W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05237","reference_uniquename":"PMID:29761456"}],"product":"Endonuclease involved in DNA recombination and repair; subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000432","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR228W"}


id: YBR229C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03280":null,"YBR229C":null},"has_protein_features":false,"name":"ROT2","ortholog_annotations":[{"gene_uniquename":"YBR229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03280","reference_uniquename":"PMID:29761456"}],"product":"Glucosidase II catalytic subunit; required to trim the final glucose in N-linked glycans; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000433","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR229C"}


id: YBR230C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OM14","product":"Mitochondrial outer membrane receptor for cytosolic ribosomes; integral protein of the outer membrane that interacts with the nascent chain-associated complex (NAC) bound to ribosomes, contributing to co-translational mitochondrial import; interacts with porin (Por1p) and Om45p; abundance is decreased in cells grown in glucose relative to other carbon sources","secondary_identifier":"SGD:S000000434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR230C"}


id: YBR230W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COQ21","product":"Mitochondrial protein of unknown function; YBR230W-A has a paralog, COQ8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000029722","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR230W-A"}


id: YBR231C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02466":null,"YBR231C":null},"has_protein_features":false,"name":"SWC5","ortholog_annotations":[{"gene_uniquename":"YBR231C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02466","reference_uniquename":"PMID:29761456"}],"product":"Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR231C"}


id: YBR232C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000436","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR232C"}


id: YBR233W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04825":null,"YBR233W":null},"has_protein_features":false,"name":"PBP2","ortholog_annotations":[{"gene_uniquename":"YBR233W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04825","reference_uniquename":"PMID:29761456"}],"product":"RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000437","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR233W"}


id: YBR233W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03437":null,"YBR233W-A":null},"has_protein_features":false,"name":"DAD3","ortholog_annotations":[{"gene_uniquename":"YBR233W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03437","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007595","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR233W-A"}


id: YBR234C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02075":null,"YBR234C":null},"has_protein_features":false,"name":"ARC40","ortholog_annotations":[{"gene_uniquename":"YBR234C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02075","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR234C"}


id: YBR235W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03401":null,"YBR235W":null},"has_protein_features":false,"name":"VHC1","ortholog_annotations":[{"gene_uniquename":"YBR235W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03401","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR235W"}


id: YBR236C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04034":null,"YBR236C":null},"has_protein_features":false,"name":"ABD1","ortholog_annotations":[{"gene_uniquename":"YBR236C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04034","reference_uniquename":"PMID:29761456"}],"product":"Methyltransferase; catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA; nuclear protein that relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000440","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR236C"}


id: YBR237W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02558":null,"YBR237W":null},"has_protein_features":false,"name":"PRP5","ortholog_annotations":[{"gene_uniquename":"YBR237W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02558","reference_uniquename":"PMID:29761456"}],"product":"RNA helicase in the DEAD-box family; necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR237W"}


id: YBR238C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Mitochondrial membrane protein; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span; YBR238C has a paralog, RMD9, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000442","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR238C"}


id: YBR239C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ERT1","product":"Transcriptional regulator; involved in regulation of gluconeogenesis and fermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition; member of the zinc cluster family of proteins, similar to Rds2p","secondary_identifier":"SGD:S000000443","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR239C"}


id: YBR240C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"THI2","product":"Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type","secondary_identifier":"SGD:S000000444","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR240C"}


id: YBR241C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"VVS1","product":"Putative transporter, member of the sugar porter family; localizes to the vacuolar membrane; non-essential gene; upregulated by and required for tolerance to 4-Methylcyclohexane methanol; YBR241C has a paralog, VPS73, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000445","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR241C"}


id: YBR242W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01055":null,"YBR242W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBR242W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01055","reference_uniquename":"PMID:29761456"}],"product":"5'-deoxynucleotidase involved in deoxyribonucleoside monophosphate degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential gene; YBR242W has a paralog, YGL101W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000446","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR242W"}


id: YBR243C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00924":null,"YBR243C":null},"has_protein_features":false,"name":"ALG7","ortholog_annotations":[{"gene_uniquename":"YBR243C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00924","reference_uniquename":"PMID:29761456"}],"product":"UDP-N-acetyl-glucosamine-1-P transferase; transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin; human homolog DPAGT1 can complement yeast ALG7 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000447","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR243C"}


id: YBR244W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01216":null,"YBR244W":null},"has_protein_features":false,"name":"GPX2","ortholog_annotations":[{"gene_uniquename":"YBR244W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01216","reference_uniquename":"PMID:29761456"}],"product":"Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000448","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR244W"}


id: YBR245C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ISW1","product":"ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; with Ioc3p forms Isw1a complex involved in repression of transcription initiation; with Ioc2p and Ioc4p forms Isw1b complex involved in regulation of transcription elongation; Isw1b recruited to ORFs by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions; Isw1p import into nucleus depends on C-terminal bipartite nuclear targeting signal KRIR X19 KKAK","secondary_identifier":"SGD:S000000449","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR245C"}


id: YBR246W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04846":null,"YBR246W":null},"has_protein_features":false,"name":"RRT2","ortholog_annotations":[{"gene_uniquename":"YBR246W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04846","reference_uniquename":"PMID:29761456"}],"product":"Methylesterase performing penultimate step of diphthamide biosynthesis; hydrolyzes methylated diphthine to produce diphthine and allows Dph6-catalyzed amidation reaction to occur; deletion leads to resistance to sordarin and accumulation of methylatediphthine; WD40 domain-containing protein; involved in endosomal recycling; forms complex with Rtt10p that functions in retromer-mediated pathway for recycling internalized cell-surface proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000450","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR246W"}


id: YBR247C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00897":null,"YBR247C":null},"has_protein_features":false,"name":"ENP1","ortholog_annotations":[{"gene_uniquename":"YBR247C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00897","reference_uniquename":"PMID:29761456"}],"product":"Protein associated with U3 and U14 snoRNAs; required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; human BYSL functionally complements the heat sensitivity of an enp1 ts mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000451","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR247C"}


id: YBR248C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03775":null,"YBR248C":null},"has_protein_features":false,"name":"HIS7","ortholog_annotations":[{"gene_uniquename":"YBR248C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03775","reference_uniquename":"PMID:29761456"}],"product":"Imidazole glycerol phosphate synthase; glutamine amidotransferase:cyclase that catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000452","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR248C"}


id: YBR249C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00224":null,"SJAG_03580":null,"YBR249C":null},"has_protein_features":false,"name":"ARO4","ortholog_annotations":[{"gene_uniquename":"YBR249C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00224","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR249C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03580","reference_uniquename":"PMID:29761456"}],"product":"3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000453","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR249C"}


id: YBR250W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPO23","product":"Protein of unknown function; associates with meiosis-specific protein Spo1p","secondary_identifier":"SGD:S000000454","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR250W"}


id: YBR251W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00628":null,"YBR251W":null},"has_protein_features":false,"name":"MRPS5","ortholog_annotations":[{"gene_uniquename":"YBR251W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00628","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR251W"}


id: YBR252W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04487":null,"YBR252W":null},"has_protein_features":false,"name":"DUT1","ortholog_annotations":[{"gene_uniquename":"YBR252W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04487","reference_uniquename":"PMID:29761456"}],"product":"Deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate; human homolog DUT allows growth of yeast haploid dut1 null mutant after sporulation of heterozygous diploid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000456","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR252W"}


id: YBR253W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05341":null,"YBR253W":null},"has_protein_features":false,"name":"SRB6","ortholog_annotations":[{"gene_uniquename":"YBR253W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05341","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000457","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR253W"}


id: YBR254C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03467":null,"YBR254C":null},"has_protein_features":false,"name":"TRS20","ortholog_annotations":[{"gene_uniquename":"YBR254C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03467","reference_uniquename":"PMID:29761456"}],"product":"Core component of transport protein particle (TRAPP) complexes I-III; TRAPPs are multimeric guanine nucleotide-exchange factors for GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); mutation leads to defects in endocytic recycling, block in sporulation/meiosis; mutations in human homolog TRAPPC2 cause spondyloepiphyseal dysplasia tarda, TRAPPC2 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000458","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR254C"}


id: YBR255C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RCF3","product":"Mitochondrial inner membrane protein; associates with respiratory chain supercomplexes III (ubiquinol-cytochrome c reductase) and IV (cytochrome c oxidase); identified by sequence comparison with hemiascomycetous yeast species","secondary_identifier":"SGD:S000007649","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR255C-A"}


id: YBR255W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MTC4","product":"Protein of unknown function; required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1","secondary_identifier":"SGD:S000000459","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR255W"}


id: YBR256C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02491":null,"YBR256C":null},"has_protein_features":false,"name":"RIB5","ortholog_annotations":[{"gene_uniquename":"YBR256C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02491","reference_uniquename":"PMID:29761456"}],"product":"Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000460","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR256C"}


id: YBR257W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01623":null,"YBR257W":null},"has_protein_features":false,"name":"POP4","ortholog_annotations":[{"gene_uniquename":"YBR257W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01623","reference_uniquename":"PMID:29761456"}],"product":"Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000461","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR257W"}


id: YBR258C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02170":null,"YBR258C":null},"has_protein_features":false,"name":"SHG1","ortholog_annotations":[{"gene_uniquename":"YBR258C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02170","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000462","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR258C"}


id: YBR259W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress","secondary_identifier":"SGD:S000000463","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR259W"}


id: YBR260C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01114":null,"YBR260C":null},"has_protein_features":false,"name":"RGD1","ortholog_annotations":[{"gene_uniquename":"YBR260C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01114","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein (RhoGAP) for Rho3p and Rho4p; involved in repolarization of actin cytoskeleton during adaptation to heat shock stress; phosphorylated by Pkc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000464","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR260C"}


id: YBR261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00508":null,"YBR261C":null},"has_protein_features":false,"name":"TAE1","ortholog_annotations":[{"gene_uniquename":"YBR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00508","reference_uniquename":"PMID:29761456"}],"product":"AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000465","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR261C"}


id: YBR262C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MIC12","product":"Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic10p and Mic27p whose assembly and stability requires cardiolipin","secondary_identifier":"SGD:S000000466","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR262C"}


id: YBR263W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03914":null,"YBR263W":null},"has_protein_features":false,"name":"SHM1","ortholog_annotations":[{"gene_uniquename":"YBR263W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03914","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000467","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR263W"}


id: YBR264C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YPT10","product":"Rab family GTP-binding protein; contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles","secondary_identifier":"SGD:S000000468","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR264C"}


id: YBR265W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02488":null,"YBR265W":null},"has_protein_features":false,"name":"TSC10","ortholog_annotations":[{"gene_uniquename":"YBR265W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02488","reference_uniquename":"PMID:29761456"}],"product":"3-ketosphinganine reductase; catalyzes the second step in phytosphingosine synthesis; essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine; localized to lipid droplets; member of short chain dehydrogenase/reductase protein family; mutations in human homolog KDSR cause recessive progressive symmetric erythrokeratoderma","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000469","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR265W"}


id: YBR266C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SLM6","product":"Protein with potential role in actin cytoskeleton organization; null mutant is slow-growing, sensitive to Congo Red, impaired in endocytosis, has increased lifespan; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase","secondary_identifier":"SGD:S000000470","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR266C"}


id: YBR267W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03697":null,"YBR267W":null},"has_protein_features":false,"name":"REI1","ortholog_annotations":[{"gene_uniquename":"YBR267W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03697","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000471","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR267W"}


id: YBR268W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05244":null,"YBR268W":null},"has_protein_features":false,"name":"MRPL37","ortholog_annotations":[{"gene_uniquename":"YBR268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05244","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR268W"}


id: YBR269C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00703":null,"YBR269C":null},"has_protein_features":false,"name":"SDH8","ortholog_annotations":[{"gene_uniquename":"YBR269C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00703","reference_uniquename":"PMID:29761456"}],"product":"Protein required for assembly of succinate dehydrogenase; interacts with flavinylated Sdh1p and may function as a chaperone for free Sdh1p, protecting its FAD cofactor from redox reactions before assembly of the complex; soluble protein of the mitochondrial matrix; respiratory defect of null mutant is functionally complemented by Drosophila and human orthologs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000473","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR269C"}


id: YBR270C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01020":null,"SJAG_04987":null,"YBR270C":null},"has_protein_features":false,"name":"BIT2","ortholog_annotations":[{"gene_uniquename":"YBR270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01020","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04987","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000474","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR270C"}


id: YBR271W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01079":null,"YBR271W":null},"has_protein_features":false,"name":"EFM2","ortholog_annotations":[{"gene_uniquename":"YBR271W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01079","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which dimethylates translation elongation factor EF2 (Eft1p and Eft2p) at lysine 613 and methylates EF3 (Yef3p) at lysine 187; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; involved in regulation of translational termination; predicted involvement in ribosome biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000475","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR271W"}


id: YBR272C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HSM3","product":"Evolutionarily conserved 19S regulatory particle assembly-chaperone; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation; ortholog of human 19S subunit S5b","secondary_identifier":"SGD:S000000476","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR272C"}


id: YBR273C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"UBX7","product":"UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000477","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR273C"}


id: YBR274W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01680":null,"YBR274W":null},"has_protein_features":false,"name":"CHK1","ortholog_annotations":[{"gene_uniquename":"YBR274W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01680","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine kinase and DNA damage checkpoint effector; mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000478","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR274W"}


id: YBR275C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01377":null,"YBR275C":null},"has_protein_features":false,"name":"RIF1","ortholog_annotations":[{"gene_uniquename":"YBR275C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01377","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in control of DNA replication; binds Rap1p C-terminus, telomeres, centromeres, replication origins; contributes to resection of DNA double strand breaks (DSBs); acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; in addition to controlling DNA replication initiation, plays ongoing role after initiation and controls events at blocked replication forks","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000479","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR275C"}


id: YBR276C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PPS1","product":"Protein phosphatase; has specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle","secondary_identifier":"SGD:S000000480","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR276C"}


id: YBR277C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W","secondary_identifier":"SGD:S000000481","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR277C"}


id: YBR278W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01823":null,"YBR278W":null},"has_protein_features":false,"name":"DPB3","ortholog_annotations":[{"gene_uniquename":"YBR278W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01823","reference_uniquename":"PMID:29761456"}],"product":"Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000482","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR278W"}


id: YBR279W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01610":null,"YBR279W":null},"has_protein_features":false,"name":"PAF1","ortholog_annotations":[{"gene_uniquename":"YBR279W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01610","reference_uniquename":"PMID:29761456"}],"product":"Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000483","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR279W"}


id: YBR280C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SAF1","product":"F-Box protein involved in proteasome-dependent degradation of Aah1p; involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1","secondary_identifier":"SGD:S000000484","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR280C"}


id: YBR281C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DUG2","product":"Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)","secondary_identifier":"SGD:S000000485","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR281C"}


id: YBR282W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04893":null,"YBR282W":null},"has_protein_features":false,"name":"MRPL27","ortholog_annotations":[{"gene_uniquename":"YBR282W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04893","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000486","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR282W"}


id: YBR283C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02208":null,"YBR283C":null},"has_protein_features":false,"name":"SSH1","ortholog_annotations":[{"gene_uniquename":"YBR283C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02208","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000487","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR283C"}


id: YBR284W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000488","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR284W"}


id: YBR285W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YBR285W is not an essential gene","secondary_identifier":"SGD:S000000489","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR285W"}


id: YBR286W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"APE3","product":"Vacuolar aminopeptidase Y; processed to mature form by Prb1p","secondary_identifier":"SGD:S000000490","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR286W"}


id: YBR287W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01514":null,"YBR287W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBR287W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01514","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000491","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR287W"}


id: YBR288C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04931":null,"YBR288C":null},"has_protein_features":false,"name":"APM3","ortholog_annotations":[{"gene_uniquename":"YBR288C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04931","reference_uniquename":"PMID:29761456"}],"product":"Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000492","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR288C"}


id: YBR289W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01111":null,"YBR289W":null},"has_protein_features":false,"name":"SNF5","ortholog_annotations":[{"gene_uniquename":"YBR289W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01111","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000493","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR289W"}


id: YBR290W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01527":null,"YBR290W":null},"has_protein_features":false,"name":"BSD2","ortholog_annotations":[{"gene_uniquename":"YBR290W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01527","reference_uniquename":"PMID:29761456"}],"product":"Heavy metal ion homeostasis protein; facilitates trafficking of Smf1p and Smf2p metal transporters to vacuole where they are degraded; acts as an adaptor protein with Rsp5p in the regulated endocytosis of Smf1p and is itself ubiquitylated by Rsp5p; controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000494","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR290W"}


id: YBR291C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01872":null,"YBR291C":null},"has_protein_features":false,"name":"CTP1","ortholog_annotations":[{"gene_uniquename":"YBR291C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01872","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000495","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR291C"}


id: YBR292C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; YBR292C is not an essential gene","secondary_identifier":"SGD:S000000496","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR292C"}


id: YBR293W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02029":null,"SJAG_04725":null,"YBR293W":null},"has_protein_features":false,"name":"VBA2","ortholog_annotations":[{"gene_uniquename":"YBR293W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02029","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR293W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04725","reference_uniquename":"PMID:29761456"}],"product":"Permease of basic amino acids in the vacuolar membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000497","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR293W"}


id: YBR294W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02463":null,"YBR294W":null},"has_protein_features":false,"name":"SUL1","ortholog_annotations":[{"gene_uniquename":"YBR294W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02463","reference_uniquename":"PMID:29761456"}],"product":"High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000498","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR294W"}


id: YBR295W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PCA1","product":"Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function","secondary_identifier":"SGD:S000000499","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR295W"}


id: YBR296C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PHO89","product":"Plasma membrane Na+/Pi cotransporter; active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification","secondary_identifier":"SGD:S000000500","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR296C"}


id: YBR296C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TYC1","product":"Inhibitor of the Anaphase-Promoting Complex/Cyclosome (APC/C); binds to APC/C and inhibits the activity of both APC/C(Cdc20) and APC/C(Cdh1); inhibits the binding of Cdc20 and Cdh1 to APC/C; overexpression results in increased sensitivity to microtubule poison; originally identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; functional homolog of human MAD2L1BP (p31comet)","secondary_identifier":"SGD:S000028605","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR296C-A"}


id: YBR297W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MAL33","product":"MAL-activator protein; part of complex locus MAL3; nonfunctional in genomic reference strain S288C","secondary_identifier":"SGD:S000000501","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR297W"}


id: YBR298C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MAL31","product":"Maltose permease; high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C","secondary_identifier":"SGD:S000000502","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR298C"}


id: YBR298C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028606","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR298C-A"}


id: YBR299W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MAL32","product":"Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose","secondary_identifier":"SGD:S000000503","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR299W"}


id: YBR300C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene","secondary_identifier":"SGD:S000000504","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR300C"}


id: YBR301W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU24","product":"Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth","secondary_identifier":"SGD:S000000505","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR301W"}


id: YBR302C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COS2","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000000506","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR302C"}


id: YCL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04402":null,"YCL001W":null},"has_protein_features":false,"name":"RER1","ortholog_annotations":[{"gene_uniquename":"YCL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04402","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in retention of membrane proteins; including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000507","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL001W"}


id: YCL001W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III","secondary_identifier":"SGD:S000007221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL001W-A"}


id: YCL001W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication","secondary_identifier":"SGD:S000007596","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL001W-B"}


id: YCL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YCL002C is not an essential gene","secondary_identifier":"SGD:S000000508","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL002C"}


id: YCL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCL003W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YCL004w","secondary_identifier":"SGD:S000000509","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL003W"}


id: YCL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00168":null,"YCL004W":null},"has_protein_features":false,"name":"PGS1","ortholog_annotations":[{"gene_uniquename":"YCL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00168","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylglycerolphosphate synthase; catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000510","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL004W"}


id: YCL005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LDB16","product":"Protein involved in lipid droplet (LD) assembly; forms a complex with Sei1p at ER-LD contact sites, stabilizing contact sites; ensures that LDs bud from the ER towards the cytosolic side of the membrane; null mutants have decreased net negative cell surface charge and localized accumulation of phosphatidic acid (PA) marker proteins; GFP-fusion protein expression is induced in response to MMS; null mutant can be complemented by the human seipin, BSCL2","secondary_identifier":"SGD:S000000511","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL005W"}


id: YCL005W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05294":null,"YCL005W-A":null},"has_protein_features":false,"name":"VMA9","ortholog_annotations":[{"gene_uniquename":"YCL005W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05294","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028508","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL005W-A"}


id: YCL006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this ORF was removed when a sequence update created a stop codon after residue 23","secondary_identifier":"SGD:S000000512","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL006C"}


id: YCL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A","secondary_identifier":"SGD:S000000513","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL007C"}


id: YCL008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01981":null,"YCL008C":null},"has_protein_features":false,"name":"STP22","ortholog_annotations":[{"gene_uniquename":"YCL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01981","reference_uniquename":"PMID:29761456"}],"product":"Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; prevents polyubiquitination of the arrestin-related protein Rim8p, thereby directing its monoubiquitination by Rsp5p; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype;","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000514","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL008C"}


id: YCL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06635":null,"YCL009C":null},"has_protein_features":false,"name":"ILV6","ortholog_annotations":[{"gene_uniquename":"YCL009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06635","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of acetolactate synthase; acetolactate synthase catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000515","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL009C"}


id: YCL010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00184":null,"YCL010C":null},"has_protein_features":false,"name":"SGF29","ortholog_annotations":[{"gene_uniquename":"YCL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00184","reference_uniquename":"PMID:29761456"}],"product":"Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000516","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL010C"}


id: YCL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01529":null,"YCL011C":null},"has_protein_features":false,"name":"GBP2","ortholog_annotations":[{"gene_uniquename":"YCL011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01529","reference_uniquename":"PMID:29761456"}],"product":"Poly(A+) RNA-binding protein; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; relocalizes to the cytosol in response to hypoxia; GBP2 has a paralog, HRB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000517","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL011C"}


id: YCL012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00725":null,"YCL012C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YCL012C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00725","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000029705","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL012C"}


id: YCL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCL012W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YCL014W","secondary_identifier":"SGD:S000000518","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL012W"}


id: YCL013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; originally included in genome annotation but deleted due to sequence correction","secondary_identifier":"SGD:S000000519","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL013W"}


id: YCL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BUD3","product":"Guanine nucleotide exchange factor (GEF) for Cdc42p; activates Cdc42p in early G1, accounting for the first stage of biphasic activation, with Cdc24p accounting for the second stage in late G1; involved in the Cdc42p-mediated assembly of the axial landmark that dictates the site for the next round of budding, resulting in the axial budding pattern observed in haploids; localizes with septins to the bud neck contractile ring in mitosis","secondary_identifier":"SGD:S000000520","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL014W"}


id: YCL016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00806":null,"YCL016C":null},"has_protein_features":false,"name":"DCC1","ortholog_annotations":[{"gene_uniquename":"YCL016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00806","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a complex with Ctf8p and Ctf18p; shares some components with Replication Factor C; required for sister chromatid cohesion and telomere length maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL016C"}


id: YCL017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00186":null,"YCL017C":null},"has_protein_features":false,"name":"NFS1","ortholog_annotations":[{"gene_uniquename":"YCL017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00186","reference_uniquename":"PMID:29761456"}],"product":"Cysteine desulfurase involved in iron-sulfur cluster biogenesis; required for thio-modification of mitochondrial and cytoplasmic tRNAs; involved in DNA damage response by providing Fe–S cluster cofactors for DNA repair enzymes; essential protein located predominantly in mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL017C"}


id: YCL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03562":null,"YCL018W":null},"has_protein_features":false,"name":"LEU2","ortholog_annotations":[{"gene_uniquename":"YCL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03562","reference_uniquename":"PMID:29761456"}],"product":"Beta-isopropylmalate dehydrogenase (IMDH); catalyzes the third step in the leucine biosynthesis pathway; can additionally catalyze the conversion of beta-ethylmalate into alpha-ketovalerate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL018W"}


id: YCL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; originally included in genome annotation, but later deleted due to sequence correction","secondary_identifier":"SGD:S000000526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL021W"}


id: YCL021W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the vacuole","secondary_identifier":"SGD:S000007549","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL021W-A"}


id: YCL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W","secondary_identifier":"SGD:S000000527","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL022C"}


id: YCL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4","secondary_identifier":"SGD:S000000528","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL023C"}


id: YCL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03602":null,"SJAG_04486":null,"YCL024W":null},"has_protein_features":false,"name":"KCC4","ortholog_annotations":[{"gene_uniquename":"YCL024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03602","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04486","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000529","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL024W"}


id: YCL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YCL025C":null},"has_protein_features":false,"name":"AGP1","ortholog_annotations":[{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"Broad-specificity, low-affinity amino acid permease; minor serine permease with major contributions from paralog Gnp1p; involved in uptake of asparagine, glutamine, and other amino acids; expression induced by amino acids and regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000530","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL025C"}


id: YCL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; included in the original annotation of Chromosome III but later deleted due to sequence corrections","secondary_identifier":"SGD:S000000531","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL026C"}


id: YCL026C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FRM2","product":"Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin","secondary_identifier":"SGD:S000000589","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL026C-A"}


id: YCL026C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HBN1","product":"Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000007548","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL026C-B"}


id: YCL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FUS1","product":"Membrane protein localized to the shmoo tip; required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate","secondary_identifier":"SGD:S000000532","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL027W"}


id: YCL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RNQ1","product":"[PIN(+)] prion; an infectious protein conformation that is generally an ordered protein aggregate","secondary_identifier":"SGD:S000000533","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL028W"}


id: YCL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02695":null,"YCL029C":null},"has_protein_features":false,"name":"BIK1","ortholog_annotations":[{"gene_uniquename":"YCL029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02695","reference_uniquename":"PMID:29761456"}],"product":"Microtubule-associated protein; component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; promotes plus-end directed movement of Dyn1p; ortholog of mammalian CLIP-170","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000534","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL029C"}


id: YCL030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01137":null,"SJAG_02400":null,"YCL030C":null},"has_protein_features":false,"name":"HIS4","ortholog_annotations":[{"gene_uniquename":"YCL030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01137","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02400","reference_uniquename":"PMID:29761456"}],"product":"Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000535","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL030C"}


id: YCL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03617":null,"YCL031C":null},"has_protein_features":false,"name":"RRP7","ortholog_annotations":[{"gene_uniquename":"YCL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03617","reference_uniquename":"PMID:29761456"}],"product":"Essential protein involved in rRNA processing and ribosome biogenesis; forms a complex with Utp22p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000536","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL031C"}


id: YCL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03340":null,"YCL032W":null},"has_protein_features":false,"name":"STE50","ortholog_annotations":[{"gene_uniquename":"YCL032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03340","reference_uniquename":"PMID:29761456"}],"product":"Adaptor protein for various signaling pathways; involved in mating response, invasive/filamentous growth, osmotolerance; acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000537","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL032W"}


id: YCL033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00365":null,"YCL033C":null},"has_protein_features":false,"name":"MXR2","ortholog_annotations":[{"gene_uniquename":"YCL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00365","reference_uniquename":"PMID:29761456"}],"product":"Methionine-R-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000538","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL033C"}


id: YCL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00907":null,"YCL034W":null},"has_protein_features":false,"name":"LSB5","ortholog_annotations":[{"gene_uniquename":"YCL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00907","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in membrane-trafficking events at plasma membrane; interacts with actin regulators Sla1p and Las17p, ubiquitin, Arf3p to couple actin dynamics to membrane trafficking processes; similar structure to GGA family of proteins with N-terminal VHS domain and GAT domain; binds Las17p, which is homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly, actin polymerization; may mediate disassembly of Pan1 complex from endocytic coat","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000539","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL034W"}


id: YCL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01292":null,"SJAG_04632":null,"YCL035C":null},"has_protein_features":false,"name":"GRX1","ortholog_annotations":[{"gene_uniquename":"YCL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01292","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04632","reference_uniquename":"PMID:29761456"}],"product":"Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000540","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL035C"}


id: YCL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03874":null,"YCL036W":null},"has_protein_features":false,"name":"GFD2","ortholog_annotations":[{"gene_uniquename":"YCL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03874","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000541","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL036W"}


id: YCL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01026":null,"YCL037C":null},"has_protein_features":false,"name":"SRO9","ortholog_annotations":[{"gene_uniquename":"YCL037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01026","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic RNA-binding protein; shuttles between nucleus and cytoplasm and is exported from the nucleus in an mRNA export-dependent manner; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000542","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL037C"}


id: YCL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03899":null,"YCL038C":null},"has_protein_features":false,"name":"ATG22","ortholog_annotations":[{"gene_uniquename":"YCL038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03899","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar integral membrane protein required for efflux of amino acids; required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000543","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL038C"}


id: YCL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01472":null,"YCL039W":null},"has_protein_features":false,"name":"GID7","ortholog_annotations":[{"gene_uniquename":"YCL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01472","reference_uniquename":"PMID:29761456"}],"product":"Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000544","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL039W"}


id: YCL040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04495":null,"YCL040W":null},"has_protein_features":false,"name":"GLK1","ortholog_annotations":[{"gene_uniquename":"YCL040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04495","reference_uniquename":"PMID:29761456"}],"product":"Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000545","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL040W"}


id: YCL041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W","secondary_identifier":"SGD:S000000546","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL041C"}


id: YCL042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm","secondary_identifier":"SGD:S000000547","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL042W"}


id: YCL043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00288":null,"YCL043C":null},"has_protein_features":false,"name":"PDI1","ortholog_annotations":[{"gene_uniquename":"YCL043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00288","reference_uniquename":"PMID:29761456"}],"product":"Protein disulfide isomerase; multifunctional oxidoreductase of the ER lumen, essential for disulfide bond formation in secretory and cell-surface proteins, processing of non-native disulfide bonds; Ero1p activator; complexes with exomannosidase, Mnl1p to facilitate the recognition of misfolded glycoproteins and the trimming of glycan Man8GlcNAc2 to Man7GlcNAc2 on substrates, thereby accelerating ERAD; PDI1 has a paralog, EUG1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000548","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL043C"}


id: YCL044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MGR1","product":"Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA","secondary_identifier":"SGD:S000000549","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL044C"}


id: YCL045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02437":null,"YCL045C":null},"has_protein_features":false,"name":"EMC1","ortholog_annotations":[{"gene_uniquename":"YCL045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02437","reference_uniquename":"PMID:29761456"}],"product":"Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000550","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL045C"}


id: YCL046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C","secondary_identifier":"SGD:S000000551","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL046W"}


id: YCL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01500":null,"YCL047C":null},"has_protein_features":false,"name":"POF1","ortholog_annotations":[{"gene_uniquename":"YCL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01500","reference_uniquename":"PMID:29761456"}],"product":"Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT); catalyzes the conversion of nicotinamide mononucleotide (NMN) to nicotinamide adenine dinucleotide (NAD+); role in the nicotinamide riboside (NR) salvage pathway of NAD+ biosynthesis; involved in NR and NAD+ homeostasis; ATPase involved in protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000552","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL047C"}


id: YCL048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00340":null,"SJAG_03483":null,"YCL048W":null},"has_protein_features":false,"name":"SPS22","ortholog_annotations":[{"gene_uniquename":"YCL048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00340","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03483","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000553","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL048W"}


id: YCL048W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCL048W-A has a paralog, YDR524C-B, that arose from the whole genome duplication","secondary_identifier":"SGD:S000087203","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL048W-A"}


id: YCL049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene","secondary_identifier":"SGD:S000000554","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL049C"}


id: YCL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"APA1","product":"AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000555","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL050C"}


id: YCL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LRE1","product":"Protein involved in control of cell wall structure and stress response; direct inhibitor of the nuclear Dbf2 related (NDR) kinase Cbk1p-Mob2p; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; LRE1 has a paralog, HLR1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000556","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL051W"}


id: YCL052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03801":null,"YCL052C":null},"has_protein_features":false,"name":"PBN1","ortholog_annotations":[{"gene_uniquename":"YCL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03801","reference_uniquename":"PMID:29761456"}],"product":"Component of glycosylphosphatidylinositol-mannosyltransferase I; essential component; required for the autocatalytic post-translational processing of the protease B precursor Prb1p; localizes to ER in lumenal orientation; homolog of mammalian PIG-X","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000557","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL052C"}


id: YCL053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; included in the original annotation of Chromosome III but later deleted due to sequence corrections","secondary_identifier":"SGD:S000000558","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL053C"}


id: YCL054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00722":null,"YCL054W":null},"has_protein_features":false,"name":"SPB1","ortholog_annotations":[{"gene_uniquename":"YCL054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00722","reference_uniquename":"PMID:29761456"}],"product":"AdoMet-dependent methyltransferase; involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000559","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL054W"}


id: YCL054W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RDT1","product":"Short open reading frame, shows evidence of translation; may be new protein-coding gene that originated de novo from noncoding sequence; same allele found in at least 33 other S. cerevisiae strains; at least 3 strains have a second allele with three nucleotide substitutions leading to two amino acid differences","secondary_identifier":"SGD:S000178054","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL054W-A"}


id: YCL055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"KAR4","product":"Transcription factor required for response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone; null mutant exhibits abnormal lipid metabolic phenotype","secondary_identifier":"SGD:S000000560","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL055W"}


id: YCL056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEX34","product":"Protein that regulates peroxisome populations; peroxisomal integral membrane protein; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation","secondary_identifier":"SGD:S000000561","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL056C"}


id: YCL057C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02002":null,"YCL057C-A":null},"has_protein_features":false,"name":"MIC10","ortholog_annotations":[{"gene_uniquename":"YCL057C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02002","reference_uniquename":"PMID:29761456"}],"product":"Conserved component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic12p and Mic27p whose assembly and stability requires cardiolipin; homo-oligomers cause membrane bending; ortholog of human MINOS1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007547","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL057C-A"}


id: YCL057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PRD1","product":"Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000000562","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL057W"}


id: YCL058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FYV5","product":"De novo-originated gene from non-coding sequence; protein can suppress mating and promote vegetative growth; shortens lag phase by physically interacting with Snf1p; binds with Matalpha2p to promoters of haploid-specific genes; functions in mating and fermentation, mediates crosstalk between reproduction and vegetative growth; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis","secondary_identifier":"SGD:S000000563","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL058C"}


id: YCL058W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ADF1","product":"Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand","secondary_identifier":"SGD:S000028518","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL058W-A"}


id: YCL059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00657":null,"YCL059C":null},"has_protein_features":false,"name":"KRR1","ortholog_annotations":[{"gene_uniquename":"YCL059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00657","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein required for rRNA synthesis and ribosomal assembly; required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000564","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL059C"}


id: YCL060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCL060C was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YCL061C","secondary_identifier":"SGD:S000000565","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL060C"}


id: YCL061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04671":null,"YCL061C":null},"has_protein_features":false,"name":"MRC1","ortholog_annotations":[{"gene_uniquename":"YCL061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04671","reference_uniquename":"PMID:29761456"}],"product":"S-phase checkpoint protein required for DNA replication; couples DNA helicase and polymerase; stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; defines a novel S-phase checkpoint with Hog1p that coordinates DNA replication and transcription upon osmostress; protects uncapped telomeres; Dia2p-dependent degradation mediates checkpoint recovery; exposure to ethanol affects localization; mammalian claspin homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL061C"}


id: YCL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCL062W as originally annotated as an independent ORF, but as a result of sequence changes, it was merged with an adjacent ORF into a single reading frame, designated YCL063W","secondary_identifier":"SGD:S000000567","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL062W"}


id: YCL063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"VAC17","product":"Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p; involved in regulation of asymmetric inheritance of aggregated/misfolded proteins and age reset","secondary_identifier":"SGD:S000000568","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL063W"}


id: YCL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CHA1","product":"Catabolic L-serine (L-threonine) deaminase; catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine","secondary_identifier":"SGD:S000000569","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL064C"}


id: YCL065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps HMLALPHA1","secondary_identifier":"SGD:S000000570","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL065W"}


id: YCL066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HMLALPHA1","product":"Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression","secondary_identifier":"SGD:S000000571","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL066W"}


id: YCL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HMLALPHA2","product":"Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression","secondary_identifier":"SGD:S000000572","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL067C"}


id: YCL068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02486":null,"SJAG_02819":null,"YCL068C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YCL068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02486","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YCL068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02819","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000000573","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL068C"}


id: YCL069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01336":null,"SJAG_01636":null,"SJAG_01923":null,"SJAG_04715":null,"SJAG_04983":null,"YCL069W":null},"has_protein_features":false,"name":"VBA3","ortholog_annotations":[{"gene_uniquename":"YCL069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01336","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01636","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01923","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04715","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04983","reference_uniquename":"PMID:29761456"}],"product":"Permease of basic amino acids in the vacuolar membrane; VBA3 has a paralog, VBA5, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000574","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL069W"}


id: YCL073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YCL073C":null},"has_protein_features":false,"name":"GEX1","ortholog_annotations":[{"gene_uniquename":"YCL073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role in resistance to oxidative stress and modulation of the PKA pathway; GEX1 has a paralog, GEX2, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000575","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL073C"}


id: YCL076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000581","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL076W"}


id: YCLX01W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"L000003336","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX01W"}


id: YCLX02C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX02C"}


id: YCLX03C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000584","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX03C"}


id: YCLX04W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000585","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX04W"}


id: YCLX05C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000586","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX05C"}


id: YCLX06C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX06C"}


id: YCLX07W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000588","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX07W"}


id: YCLX09W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000590","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX09W"}


id: YCLX10C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000591","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX10C"}


id: YCLX11W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000592","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX11W"}


id: YCLX12W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000593","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX12W"}


id: YCR001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YCR001W is not an essential gene","secondary_identifier":"SGD:S000000594","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR001W"}


id: YCR002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00663":null,"YCR002C":null},"has_protein_features":false,"name":"CDC10","ortholog_annotations":[{"gene_uniquename":"YCR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00663","reference_uniquename":"PMID:29761456"}],"product":"Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000595","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR002C"}


id: YCR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00844":null,"YCR003W":null},"has_protein_features":false,"name":"MRPL32","ortholog_annotations":[{"gene_uniquename":"YCR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00844","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000596","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR003W"}


id: YCR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02697":null,"YCR004C":null},"has_protein_features":false,"name":"YCP4","ortholog_annotations":[{"gene_uniquename":"YCR004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02697","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000597","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR004C"}


id: YCR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01922":null,"YCR005C":null},"has_protein_features":false,"name":"CIT2","ortholog_annotations":[{"gene_uniquename":"YCR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01922","reference_uniquename":"PMID:29761456"}],"product":"Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate; expression is controlled by Rtg1p and Rtg2p transcription factors; SCF-Ucc1 regulates level of Cit2p to maintain citrate homeostasis; oxaloacetate-dependent positive feedback loop inhibits Cit2p ubiquitination; CIT2 has a paralog, CIT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000598","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR005C"}


id: YCR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YCR006C is not an essential gene","secondary_identifier":"SGD:S000000599","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR006C"}


id: YCR007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative integral membrane protein; member of DUP240 gene family; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCR007C is not an essential gene","secondary_identifier":"SGD:S000000600","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR007C"}


id: YCR008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04760":null,"YCR008W":null},"has_protein_features":false,"name":"SAT4","ortholog_annotations":[{"gene_uniquename":"YCR008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04760","reference_uniquename":"PMID:29761456"}],"product":"Ser/Thr protein kinase involved in salt tolerance, nutrient response; functions in regulation of Trk1p-Trk2p potassium transporter; overexpression affects the Fe-S and lipoamide containing proteins in the mitochondrion; required for lipoylation of Lat1p, Kgd2p and Gcv3p; partially redundant with Hal5p; has similarity to Npr1p; localizes to the cytoplasm and mitochondrion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000601","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR008W"}


id: YCR009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00700":null,"YCR009C":null},"has_protein_features":false,"name":"RVS161","ortholog_annotations":[{"gene_uniquename":"YCR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00700","reference_uniquename":"PMID:29761456"}],"product":"Amphiphysin-like lipid raft protein; N-BAR domain protein that interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000602","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR009C"}


id: YCR010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01505":null,"YCR010C":null},"has_protein_features":false,"name":"ADY2","ortholog_annotations":[{"gene_uniquename":"YCR010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01505","reference_uniquename":"PMID:29761456"}],"product":"Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000603","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR010C"}


id: YCR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04277":null,"YCR011C":null},"has_protein_features":false,"name":"ADP1","ortholog_annotations":[{"gene_uniquename":"YCR011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Putative ATP-dependent permease of the ABC transporter family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000604","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR011C"}


id: YCR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03660":null,"YCR012W":null},"has_protein_features":false,"name":"PGK1","ortholog_annotations":[{"gene_uniquename":"YCR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03660","reference_uniquename":"PMID:29761456"}],"product":"3-phosphoglycerate kinase; catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000605","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR012W"}


id: YCR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant","secondary_identifier":"SGD:S000000606","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR013C"}


id: YCR014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_16460":null,"YCR014C":null},"has_protein_features":false,"name":"POL4","ortholog_annotations":[{"gene_uniquename":"YCR014C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16460","reference_uniquename":"PMID:29761456"}],"product":"DNA polymerase IV; undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000607","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR014C"}


id: YCR015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00463":null,"YCR015C":null},"has_protein_features":false,"name":"CTO1","ortholog_annotations":[{"gene_uniquename":"YCR015C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00463","reference_uniquename":"PMID:29761456"}],"product":"Protein required for cold tolerance; involved in phosphate uptake; YCR015C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR015C"}


id: YCR016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis","secondary_identifier":"SGD:S000000609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR016W"}


id: YCR017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01227":null,"YCR017C":null},"has_protein_features":false,"name":"CWH43","ortholog_annotations":[{"gene_uniquename":"YCR017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01227","reference_uniquename":"PMID:29761456"}],"product":"GPI lipid remodelase; responsible for introducing ceramides into GPI anchors having a C26:0 fatty acid in sn-2 of the glycerol moiety; can also use lyso-GPI protein anchors and various base resistant lipids as substrates; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000610","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR017C"}


id: YCR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SRD1","product":"Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation","secondary_identifier":"SGD:S000000611","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR018C"}


id: YCR018C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; encoded opposite a Ty1 LTR","secondary_identifier":"SGD:S000007230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR018C-A"}


id: YCR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03880":null,"YCR019W":null},"has_protein_features":false,"name":"MAK32","ortholog_annotations":[{"gene_uniquename":"YCR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03880","reference_uniquename":"PMID:29761456"}],"product":"Protein necessary for stability of L-A dsRNA-containing particles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000612","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR019W"}


id: YCR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PET18","product":"Protein of unknown function; has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin","secondary_identifier":"SGD:S000000613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR020C"}


id: YCR020C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06449":null,"YCR020C-A":null},"has_protein_features":false,"name":"MAK31","ortholog_annotations":[{"gene_uniquename":"YCR020C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06449","reference_uniquename":"PMID:29761456"}],"product":"Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000614","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR020C-A"}


id: YCR020W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HTL1","product":"Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance","secondary_identifier":"SGD:S000006439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR020W-B"}


id: YCR021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02533":null,"YCR021C":null},"has_protein_features":false,"name":"HSP30","ortholog_annotations":[{"gene_uniquename":"YCR021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02533","reference_uniquename":"PMID:29761456"}],"product":"Negative regulator of the H(+)-ATPase Pma1p; stress-responsive protein; hydrophobic plasma membrane localized; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000615","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR021C"}


id: YCR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YCR022C is not an essential gene","secondary_identifier":"SGD:S000000616","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR022C"}


id: YCR023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene","secondary_identifier":"SGD:S000000617","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR023C"}


id: YCR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04856":null,"YCR024C":null},"has_protein_features":false,"name":"SLM5","ortholog_annotations":[{"gene_uniquename":"YCR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04856","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial asparaginyl-tRNA synthetase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000618","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR024C"}


id: YCR024C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PMP1","product":"Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR024C-A"}


id: YCR024C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028818","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR024C-B"}


id: YCR025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; YCR025C is not an essential gene","secondary_identifier":"SGD:S000000620","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR025C"}


id: YCR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00705":null,"YCR026C":null},"has_protein_features":false,"name":"NPP1","ortholog_annotations":[{"gene_uniquename":"YCR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00705","reference_uniquename":"PMID:29761456"}],"product":"Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; NPP1 has a paralog, NPP2, that arose from the whole genome duplication, and an npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000621","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR026C"}


id: YCR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02605":null,"YCR027C":null},"has_protein_features":false,"name":"RHB1","ortholog_annotations":[{"gene_uniquename":"YCR027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02605","reference_uniquename":"PMID:29761456"}],"product":"Putative Rheb-related GTPase; involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000622","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR027C"}


id: YCR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05175":null,"YCR028C":null},"has_protein_features":false,"name":"FEN2","ortholog_annotations":[{"gene_uniquename":"YCR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05175","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000623","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR028C"}


id: YCR028C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03957":null,"YCR028C-A":null},"has_protein_features":false,"name":"RIM1","ortholog_annotations":[{"gene_uniquename":"YCR028C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03957","reference_uniquename":"PMID:29761456"}],"product":"ssDNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication; stimulates utilization by Mip1p DNA polymerase of RNA primers synthesized by Rpo41p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007222","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR028C-A"}


id: YCR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; included in the original annotation of Chromosome III but deleted due to sequence correction","secondary_identifier":"SGD:S000000624","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR029C"}


id: YCR029C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a protein; YCR029C-A was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YCR030C","secondary_identifier":"SGD:S000000625","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR029C-A"}


id: YCR030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03146":null,"YCR030C":null},"has_protein_features":false,"name":"SYP1","ortholog_annotations":[{"gene_uniquename":"YCR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03146","reference_uniquename":"PMID:29761456"}],"product":"Negative regulator of WASP-Arp23 complex; involved in endocytic site formation; directly inhibits Las17p stimulation of Arp23 complex-mediated actin assembly in vitro; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR030C"}


id: YCR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01548":null,"SJAG_03424":null,"YCR031C":null},"has_protein_features":false,"name":"RPS14A","ortholog_annotations":[{"gene_uniquename":"YCR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01548","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03424","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR031C"}


id: YCR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05245":null,"YCR032W":null},"has_protein_features":false,"name":"BPH1","ortholog_annotations":[{"gene_uniquename":"YCR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05245","reference_uniquename":"PMID:29761456"}],"product":"Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR032W"}


id: YCR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04389":null,"YCR033W":null},"has_protein_features":false,"name":"SNT1","ortholog_annotations":[{"gene_uniquename":"YCR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04389","reference_uniquename":"PMID:29761456"}],"product":"Set3C histone deacetylase scaffold; can act as prion [ESI+] (Expressed Subtelomeric Information) that drives emergence and transgenerational inheritance of activated chromatin state; prion conformer is triggered by transient Snt1p phosphorylation upon cell cycle arrest; [ESI+] reshapes the activity Set3C, recruiting RNAPII, interfering with Rap1p binding to activate genes in otherwise repressed subtelomeric domains; relocalizes to cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR033W"}


id: YCR034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01356":null,"SJAG_02885":null,"YCR034W":null},"has_protein_features":false,"name":"ELO2","ortholog_annotations":[{"gene_uniquename":"YCR034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01356","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02885","reference_uniquename":"PMID:29761456"}],"product":"Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; ELO2 has a paralog, ELO1, that arose from the whole genome duplication; lethality of the elo2 elo3 double null mutation is functionally complemented by human ELOVL1 and weakly complemented by human ELOVL3 or ELOV7","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR034W"}


id: YCR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04084":null,"YCR035C":null},"has_protein_features":false,"name":"RRP43","ortholog_annotations":[{"gene_uniquename":"YCR035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04084","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR035C"}


id: YCR036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03174":null,"YCR036W":null},"has_protein_features":false,"name":"RBK1","ortholog_annotations":[{"gene_uniquename":"YCR036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03174","reference_uniquename":"PMID:29761456"}],"product":"Ribokinase, phosphorylates ribose to ribose-5-phosphate; required for recycling ribose during nucleotide metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR036W"}


id: YCR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01059":null,"YCR037C":null},"has_protein_features":false,"name":"PHO87","ortholog_annotations":[{"gene_uniquename":"YCR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01059","reference_uniquename":"PMID:29761456"}],"product":"Low-affinity inorganic phosphate (Pi) transporter; acts upstream of Pho81p in regulation of the PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000633","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR037C"}


id: YCR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02486":null,"SJAG_02819":null,"YCR038C":null},"has_protein_features":false,"name":"BUD5","ortholog_annotations":[{"gene_uniquename":"YCR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02486","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YCR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02819","reference_uniquename":"PMID:26896847"}],"product":"GTP/GDP exchange factor for Rsr1p (Bud1p); required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000000634","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR038C"}


id: YCR038W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene BUD5/YCR038C; identified by homology with hemiascomycetous yeast species","secondary_identifier":"SGD:S000007597","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR038W-A"}


id: YCR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MATALPHA2","product":"Homeobox-domain protein; with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette","secondary_identifier":"SGD:S000000635","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR039C"}


id: YCR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MATALPHA1","product":"Transcriptional co-activator that regulates mating-type-specific genes; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha mating type cassette","secondary_identifier":"SGD:S000000636","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR040W"}


id: YCR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; overexpression suppresses the high-frequency loss of mini-chromosomes, probably by increasing the rate of proper chromosome segregation; translated gene product of YCR041W, but not its transcript, is responsible for suppression; suppression ability of YCR041W is completely dependent on silencing protein Sir4p","secondary_identifier":"SGD:S000000637","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR041W"}


id: YCR042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04917":null,"YCR042C":null},"has_protein_features":false,"name":"TAF2","ortholog_annotations":[{"gene_uniquename":"YCR042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04917","reference_uniquename":"PMID:29761456"}],"product":"TFIID subunit (150 kDa); involved in RNA polymerase II transcription initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR042C"}


id: YCR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene","secondary_identifier":"SGD:S000000639","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR043C"}


id: YCR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04975":null,"YCR044C":null},"has_protein_features":false,"name":"PER1","ortholog_annotations":[{"gene_uniquename":"YCR044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04975","reference_uniquename":"PMID:29761456"}],"product":"Protein of the endoplasmic reticulum; required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000640","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR044C"}


id: YCR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RRT12","product":"Probable subtilisin-family protease; role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores","secondary_identifier":"SGD:S000000641","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR045C"}


id: YCR045W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with YCR045C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028607","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR045W-A"}


id: YCR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01473":null,"YCR046C":null},"has_protein_features":false,"name":"IMG1","ortholog_annotations":[{"gene_uniquename":"YCR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01473","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; required for respiration and for maintenance of the mitochondrial genome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR046C"}


id: YCR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02281":null,"YCR047C":null},"has_protein_features":false,"name":"BUD23","ortholog_annotations":[{"gene_uniquename":"YCR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02281","reference_uniquename":"PMID:29761456"}],"product":"Methyltransferase that methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; functions with DEAH-box RNA helicase Ecm16p; diploid mutant displays random budding pattern; functional homolog of human WBSCR22","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR047C"}


id: YCR047W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with YCR047C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR047W-A"}


id: YCR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04049":null,"SJAG_04059":null,"YCR048W":null},"has_protein_features":false,"name":"ARE1","ortholog_annotations":[{"gene_uniquename":"YCR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04049","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04059","reference_uniquename":"PMID:29761456"}],"product":"Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR048W"}


id: YCR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR049C"}


id: YCR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein","secondary_identifier":"SGD:S000000646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR050C"}


id: YCR051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01812":null,"YCR051W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YCR051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01812","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR051W"}


id: YCR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00739":null,"YCR052W":null},"has_protein_features":false,"name":"RSC6","ortholog_annotations":[{"gene_uniquename":"YCR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00739","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; essential for mitotic growth; RSC6 has a paralog, SNF12, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000648","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR052W"}


id: YCR053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00432":null,"YCR053W":null},"has_protein_features":false,"name":"THR4","ortholog_annotations":[{"gene_uniquename":"YCR053W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00432","reference_uniquename":"PMID:29761456"}],"product":"Threonine synthase; conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000649","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR053W"}


id: YCR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03692":null,"YCR054C":null},"has_protein_features":false,"name":"CTR86","ortholog_annotations":[{"gene_uniquename":"YCR054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03692","reference_uniquename":"PMID:29761456"}],"product":"Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000650","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR054C"}


id: YCR055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCR055C was originally annotated as an independent ORF, but as a result of sequence changes, it was merged with two other ORFs into a single reading frame, designated YCR057C","secondary_identifier":"SGD:S000000651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR055C"}


id: YCR056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; originally included in genome annotation, but later deleted due to sequence correction","secondary_identifier":"SGD:S000000652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR056W"}


id: YCR057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00572":null,"YCR057C":null},"has_protein_features":false,"name":"PWP2","ortholog_annotations":[{"gene_uniquename":"YCR057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00572","reference_uniquename":"PMID:29761456"}],"product":"Conserved 90S pre-ribosomal component; essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000653","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR057C"}


id: YCR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCR058C was originally annotated as an independent ORF, but as a result of sequence changes, it was merged with two other ORFs into a single reading frame, designated YCR057C","secondary_identifier":"SGD:S000000654","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR058C"}


id: YCR059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04873":null,"YCR059C":null},"has_protein_features":false,"name":"YIH1","ortholog_annotations":[{"gene_uniquename":"YCR059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04873","reference_uniquename":"PMID:29761456"}],"product":"Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR059C"}


id: YCR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TAH1","product":"Component of conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly of large protein complexes such as box C/D snoRNPs and RNA polymerase II; contains a single TPR domain with at least two TPR motifs; plays a role in determining prion variants","secondary_identifier":"SGD:S000000656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR060W"}


id: YCR061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TVS1","product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; non-essential gene; upregulated by and required for tolerance to 4-Methylcyclohexane methanol; induced by treatment with 8-methoxypsoralen and UVA irradiation; contains 10-11 predicted transmembrane domains","secondary_identifier":"SGD:S000000657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR061W"}


id: YCR062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCR062W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YCR061W","secondary_identifier":"SGD:S000000658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR062W"}


id: YCR063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02227":null,"YCR063W":null},"has_protein_features":false,"name":"BUD31","ortholog_annotations":[{"gene_uniquename":"YCR063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02227","reference_uniquename":"PMID:29761456"}],"product":"Component of the SF3b subcomplex of the U2 snRNP; increases efficiency of first and second step pre-mRNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR063W"}


id: YCR064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BUD31","secondary_identifier":"SGD:S000000660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR064C"}


id: YCR065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03143":null,"SJAG_05288":null,"YCR065W":null},"has_protein_features":false,"name":"HCM1","ortholog_annotations":[{"gene_uniquename":"YCR065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03143","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05288","reference_uniquename":"PMID:29761456"}],"product":"Forkhead transcription factor; drives S-phase activation of genes involved in chromosome segregation, spindle dynamics, budding; also activates genes involved in respiration, use of alternative energy sources, NAD synthesis, oxidative stress resistance; regulated by cell wall integrity checkpoint; key factor in early adaptation to nutrient deficiency and diauxic shift; suppressor of calmodulin mutants with specific SPB assembly defects; ortholog of C. elegans lifespan regulator PHA-4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR065W"}


id: YCR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00819":null,"YCR066W":null},"has_protein_features":false,"name":"RAD18","ortholog_annotations":[{"gene_uniquename":"YCR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00819","reference_uniquename":"PMID:29761456"}],"product":"E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR066W"}


id: YCR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SED4","product":"Integral ER membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; SED4 has a paralog, SEC12, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000663","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR067C"}


id: YCR068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02100":null,"YCR068W":null},"has_protein_features":false,"name":"ATG15","ortholog_annotations":[{"gene_uniquename":"YCR068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02100","reference_uniquename":"PMID:29761456"}],"product":"Phospholipase; preferentially hydrolyses phosphatidylserine, with minor activity against cardiolipin and phosphatidylethanolamine; required for lysis of autophagic and CVT bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway; required for the maintenance of lipid droplet quantity after the diauxic shift; regulates lipolysis; expression regulated by Yap1p during autophagy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000664","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR068W"}


id: YCR069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CPR4","product":"Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; CPR4 has a paralog, CPR8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000665","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR069W"}


id: YCR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted open reading frame; YCR070W was originally annotated as an ORF, but upon further review was deleted from the genome annotation","secondary_identifier":"SGD:S000000666","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR070W"}


id: YCR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IMG2","product":"Mitochondrial ribosomal protein of the large subunit; conserved in metazoa, with similarity to human mitochondrial ribosomal protein MRPL49","secondary_identifier":"SGD:S000000667","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR071C"}


id: YCR072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02754":null,"YCR072C":null},"has_protein_features":false,"name":"RSA4","ortholog_annotations":[{"gene_uniquename":"YCR072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02754","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal large subunit (60S) assembly factor; association of the N-terminal ubiquitin-like (UBL) domain of this preribosomal factor with the MIDAS domain in the Rea1p tail, promoted by the GTPase Nog2p, is required for the ATP-dependent dissociation of preribosomal factors including the Rix1p subcomplex, Rea1p, Nog2p and Rsa1p itself prior to nuclear export of pre-60S particles; contains WD-repeats and a UBL domain; localizes to the nucleolus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000668","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR072C"}


id: YCR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03384":null,"SJAG_04777":null,"YCR073C":null},"has_protein_features":false,"name":"SSK22","ortholog_annotations":[{"gene_uniquename":"YCR073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03384","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04777","reference_uniquename":"PMID:29761456"}],"product":"MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; functionally redundant with Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p; SSK22 has a paralog, SSK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR073C"}


id: YCR073W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01824":null,"YCR073W-A":null},"has_protein_features":false,"name":"SOL2","ortholog_annotations":[{"gene_uniquename":"YCR073W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01824","reference_uniquename":"PMID:29761456"}],"product":"Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000718","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR073W-A"}


id: YCR074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; included in the original annotation of Chromosome III but later withdrawn","secondary_identifier":"SGD:S000119982","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR074C"}


id: YCR075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ERS1","product":"Protein involved in cystine transport; localizes to the vacuole, plasma membrane and endosome; similarity to human cystinosin, a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains; mutation is functionally complemented by human CTNS","secondary_identifier":"SGD:S000000671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR075C"}


id: YCR075W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"EGO2","product":"Subunit of the EGO/GSE complex; the vacuolar/endosomal membrane associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from the endosome to the plasma membrane; identified by homology to Ashbya gossypii; EGO2 has a paralog, EGO4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000028519","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR075W-A"}


id: YCR076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04633":null,"YCR076C":null},"has_protein_features":false,"name":"FUB1","ortholog_annotations":[{"gene_uniquename":"YCR076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04633","reference_uniquename":"PMID:29761456"}],"product":"Proteasome-binding protein; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; exhibits boundary activity which blocks the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR076C"}


id: YCR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02213":null,"YCR077C":null},"has_protein_features":false,"name":"PAT1","ortholog_annotations":[{"gene_uniquename":"YCR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02213","reference_uniquename":"PMID:29761456"}],"product":"Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; binds to mRNAs under glucose starvation, most often in the 3' UTR; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress; phosphorylation by PKA inhibits P body foci formation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR077C"}


id: YCR079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02433":null,"YCR079W":null},"has_protein_features":false,"name":"PTC6","ortholog_annotations":[{"gene_uniquename":"YCR079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02433","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial type 2C protein phosphatase (PP2C); has similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002133","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR079W"}


id: YCR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCR080W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YCR081W","secondary_identifier":"SGD:S000000676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR080W"}


id: YCR081C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with SRB8/YCR081W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR081C-A"}


id: YCR081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00156":null,"YCR081W":null},"has_protein_features":false,"name":"SRB8","ortholog_annotations":[{"gene_uniquename":"YCR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00156","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR081W"}


id: YCR082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AHC2","product":"Component of the ADA histone acetyltransferase complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ahc1p to the complex","secondary_identifier":"SGD:S000000678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR082W"}


id: YCR083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00614":null,"SJAG_04953":null,"YCR083W":null},"has_protein_features":false,"name":"TRX3","ortholog_annotations":[{"gene_uniquename":"YCR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00614","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04953","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial thioredoxin; highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000679","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR083W"}


id: YCR084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00290":null,"SJAG_04921":null,"YCR084C":null},"has_protein_features":false,"name":"TUP1","ortholog_annotations":[{"gene_uniquename":"YCR084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00290","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04921","reference_uniquename":"PMID:29761456"}],"product":"General repressor of transcription, forms complex with Cyc8p; involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4 and stabilization of nucleosomes over promoters; appears to enhance expression of mating-related genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000680","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR084C"}


id: YCR085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YCR085W is not an essential gene","secondary_identifier":"SGD:S000000681","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR085W"}


id: YCR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00207":null,"YCR086W":null},"has_protein_features":false,"name":"CSM1","ortholog_annotations":[{"gene_uniquename":"YCR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00207","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein that mediates homolog segregation during meiosis I; forms a complex with Lrs4p and then Mam1p at kinetochores; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000682","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR086W"}


id: YCR087C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00410":null,"YCR087C-A":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YCR087C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00410","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR087C-A"}


id: YCR087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene","secondary_identifier":"SGD:S000000683","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR087W"}


id: YCR088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02566":null,"YCR088W":null},"has_protein_features":false,"name":"ABP1","ortholog_annotations":[{"gene_uniquename":"YCR088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02566","reference_uniquename":"PMID:29761456"}],"product":"Actin-binding protein of the cortical actin cytoskeleton; important for activation of actin nucleation mediated by the Arp2/Arp3 complex; inhibits actin filament elongation at the barbed-end; phosphorylation within its proline-rich region, mediated by Cdc28p and Pho85p, protects Abp1p from PEST sequence-mediated proteolysis; mammalian homolog of HIP-55 (hematopoietic progenitor kinase 1 [HPK1]-interacting protein of 55 kDa)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR088W"}


id: YCR089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FIG2","product":"Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating; FIG2 has a paralog, AGA1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000685","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR089W"}


id: YCR090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01266":null,"YCR090C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YCR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01266","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000686","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR090C"}


id: YCR091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03209":null,"SJAG_04734":null,"YCR091W":null},"has_protein_features":false,"name":"KIN82","ortholog_annotations":[{"gene_uniquename":"YCR091W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03209","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR091W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04734","reference_uniquename":"PMID:29761456"}],"product":"Putative serine/threonine protein kinase; implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases); involved in the phosphorylation of upstream inhibitory kinase Ypk1p along with Fpk1p; has a redundant role in the cellular response to mating pheromone; KIN82 has a paralog, FPK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000687","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR091W"}


id: YCR092C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01419":null,"YCR092C":null},"has_protein_features":false,"name":"MSH3","ortholog_annotations":[{"gene_uniquename":"YCR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01419","reference_uniquename":"PMID:29761456"}],"product":"Mismatch repair protein; forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000688","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR092C"}


id: YCR093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03597":null,"YCR093W":null},"has_protein_features":false,"name":"CDC39","ortholog_annotations":[{"gene_uniquename":"YCR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03597","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the CCR4-NOT1 core complex; this complex has multiple roles in the regulation of mRNA levels including regulation of transcription and destabilization of mRNA by deadenylation; basal transcription factor that increases initiation and elongation; activates the ATPase activity of Dhh1p, resulting in processing body disassembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000689","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR093W"}


id: YCR094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02516":null,"SJAG_03050":null,"YCR094W":null},"has_protein_features":false,"name":"CDC50","ortholog_annotations":[{"gene_uniquename":"YCR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02516","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03050","reference_uniquename":"PMID:29761456"}],"product":"Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000690","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR094W"}


id: YCR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OCA4","product":"Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts","secondary_identifier":"SGD:S000000691","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR095C"}


id: YCR095W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000029724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR095W-A"}


id: YCR096C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HMRA2","product":"Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system","secondary_identifier":"SGD:S000000692","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR096C"}


id: YCR097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HMRA1","product":"Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells","secondary_identifier":"SGD:S000000694","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR097W"}


id: YCR097W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by homology to a hemiascomycetous yeast protein","secondary_identifier":"SGD:S000007632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR097W-A"}


id: YCR097WA
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a protein; YCR097WA refers to an incorrect annotation of HMRA1 that appeared in the original version of Chromosome III (1996) but was later withdrawn and subsequently removed from SGD","secondary_identifier":"SGD:S000000693","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR097WA"}


id: YCR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00232":null,"SJAG_03644":null,"SJAG_05325":null,"YCR098C":null},"has_protein_features":false,"name":"GIT1","ortholog_annotations":[{"gene_uniquename":"YCR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00232","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03644","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05325","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000695","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR098C"}


id: YCR099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000000696","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR099C"}


id: YCR100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"EMA35","product":"Protein involved in protein sorting; involved in targeting mitochondrial membrane proteins to mitochondrial translocation system; mutation causes respiration defects","secondary_identifier":"SGD:S000000697","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR100C"}


