# genes

id: YOR257W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01760":null,"YOR257W":null},"has_protein_features":false,"name":"CDC31","ortholog_annotations":[{"gene_uniquename":"YOR257W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01760","reference_uniquename":"PMID:29761456"}],"product":"Calcium-binding component of the spindle pole body (SPB) half-bridge; required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005783","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR257W"}


id: YOR258W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04410":null,"YOR258W":null},"has_protein_features":false,"name":"HNT3","ortholog_annotations":[{"gene_uniquename":"YOR258W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04410","reference_uniquename":"PMID:29761456"}],"product":"DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR258W"}


id: YOR259C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00766":null,"YOR259C":null},"has_protein_features":false,"name":"RPT4","ortholog_annotations":[{"gene_uniquename":"YOR259C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00766","reference_uniquename":"PMID:29761456"}],"product":"ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005785","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR259C"}


id: YOR260W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01659":null,"YOR260W":null},"has_protein_features":false,"name":"GCD1","ortholog_annotations":[{"gene_uniquename":"YOR260W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01659","reference_uniquename":"PMID:29761456"}],"product":"Gamma subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005786","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR260W"}


id: YOR261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00762":null,"YOR261C":null},"has_protein_features":false,"name":"RPN8","ortholog_annotations":[{"gene_uniquename":"YOR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00762","reference_uniquename":"PMID:29761456"}],"product":"Essential non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005787","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR261C"}


id: YOR262W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00065":null,"YOR262W":null},"has_protein_features":false,"name":"GPN2","ortholog_annotations":[{"gene_uniquename":"YOR262W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00065","reference_uniquename":"PMID:29761456"}],"product":"Putative GTPase with a specific role in RNA pol II and polIII biogenesis; involved in the assembly and subsequent nuclear import of RNA polymerases II and III; required for establishment of sister chromatid cohesion; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005788","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR262W"}


id: YOR263C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W","secondary_identifier":"SGD:S000005789","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR263C"}


id: YOR264W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DSE3","product":"Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress; interacts with Csm1p","secondary_identifier":"SGD:S000005790","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR264W"}


id: YOR265W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02270":null,"YOR265W":null},"has_protein_features":false,"name":"RBL2","ortholog_annotations":[{"gene_uniquename":"YOR265W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02270","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005791","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR265W"}


id: YOR266W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PNT1","product":"Mitochondrial integral inner membrane protein; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine","secondary_identifier":"SGD:S000005792","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR266W"}


id: YOR267C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00963":null,"SJAG_04268":null,"YOR267C":null},"has_protein_features":false,"name":"HRK1","ortholog_annotations":[{"gene_uniquename":"YOR267C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00963","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR267C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04268","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005793","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR267C"}


id: YOR268C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; sporulation is abnormal in homozygous diploid; SWAT-GFP fusion protein localizes to the nucleus; YOR268C is not an essential gene","secondary_identifier":"SGD:S000005794","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR268C"}


id: YOR269W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00511":null,"YOR269W":null},"has_protein_features":false,"name":"PAC1","ortholog_annotations":[{"gene_uniquename":"YOR269W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00511","reference_uniquename":"PMID:26896847"}],"product":"Regulator of dynein, involved in intracellular transport; part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000005795","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR269W"}


id: YOR270C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00516":null,"YOR270C":null},"has_protein_features":false,"name":"VPH1","ortholog_annotations":[{"gene_uniquename":"YOR270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00516","reference_uniquename":"PMID:29761456"}],"product":"Subunit a of the vacuolar-ATPase V0 domain; encodes one of two isoforms, located in vacuolar V-ATPase complexes while STV1 encodes the second isoform and is located in Golgi and endosomal V-ATPase complexes; interaction with PI(3,5)P2 increases V-ATPase activity and contributes to hyperosmotic stress tolerance; relative distribution to the vacuolar membrane decreases upon DNA replication stress; human homolog ATP6V0A4 implicated in renal tubular acidosis, can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005796","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR270C"}


id: YOR271C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04588":null,"YOR271C":null},"has_protein_features":false,"name":"FSF1","ortholog_annotations":[{"gene_uniquename":"YOR271C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04588","reference_uniquename":"PMID:29761456"}],"product":"Putative protein; predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005797","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR271C"}


id: YOR272W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02759":null,"YOR272W":null},"has_protein_features":false,"name":"YTM1","ortholog_annotations":[{"gene_uniquename":"YOR272W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02759","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal assembly factor and 66S pre-ribosomal particle constituent; subunit of the Nop7-subcomplex (PeBoW complex), required for an early nucleolar step in pre-60S ribosomal particle maturation; interaction of its ubiquitin-like (UBL) domain with the MIDAS domain in the Rea1p tail triggers release of the subcomplex and possibly other biogenesis factors via cycles of ATP hydrolysis; involved in the processing of 27S pre-rRNA; contains an N-terminal UBL domain and seven C-terminal WD repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005798","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR272W"}


id: YOR273C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TPO4","product":"Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane","secondary_identifier":"SGD:S000005799","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR273C"}


id: YOR274W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01575":null,"YOR274W":null},"has_protein_features":false,"name":"MOD5","ortholog_annotations":[{"gene_uniquename":"YOR274W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01575","reference_uniquename":"PMID:29761456"}],"product":"Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; also has a role in tRNA gene-mediated silencing; gene encodes two isozymic forms; converts to a prion form, prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis; homolog of human TRIT1, a mutation in which is associated with severe combined respiratory chain defects","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005800","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR274W"}


id: YOR275C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02584":null,"SJAG_03891":null,"YOR275C":null},"has_protein_features":false,"name":"RIM20","ortholog_annotations":[{"gene_uniquename":"YOR275C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02584","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOR275C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03891","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005801","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR275C"}


id: YOR276W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CAF20","product":"Phosphoprotein of the mRNA cap-binding complex; involved in translational control; repressor of cap-dependent translational initiation; translational activator of select mRNAs during filamentous growth; competes with eIF4G for binding to eIF4E","secondary_identifier":"SGD:S000005802","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR276W"}


id: YOR277C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20","secondary_identifier":"SGD:S000005803","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR277C"}


id: YOR278W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05283":null,"YOR278W":null},"has_protein_features":false,"name":"HEM4","ortholog_annotations":[{"gene_uniquename":"YOR278W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05283","reference_uniquename":"PMID:29761456"}],"product":"Uroporphyrinogen III synthase; catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005804","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR278W"}


id: YOR279C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RFM1","product":"Component of the Sum1p-Rfm1p-Hst1p complex; Rfm1p tethers the Hst1p histone deacetylase to the DNA-binding protein Sum1p; complex is involved in transcriptional repression of middle sporulation genes and in initiation of DNA replication","secondary_identifier":"SGD:S000005805","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR279C"}


id: YOR280C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01198":null,"SJAG_03760":null,"YOR280C":null},"has_protein_features":false,"name":"FSH3","ortholog_annotations":[{"gene_uniquename":"YOR280C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01198","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR280C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03760","reference_uniquename":"PMID:26896847"}],"product":"Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR280C"}


id: YOR281C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00558":null,"YOR281C":null},"has_protein_features":false,"name":"PLP2","ortholog_annotations":[{"gene_uniquename":"YOR281C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00558","reference_uniquename":"PMID:29761456"}],"product":"Protein that interacts with the CCT complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP; CCT is short for chaperonin containing TCP-1; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR281C"}


id: YOR282W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C","secondary_identifier":"SGD:S000005808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR282W"}


id: YOR283W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00685":null,"YOR283W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR283W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00685","reference_uniquename":"PMID:29761456"}],"product":"Phosphatase with a broad substrate specificity; has some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005809","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR283W"}


id: YOR284W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HUA2","product":"Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly","secondary_identifier":"SGD:S000005810","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR284W"}


id: YOR285W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01239":null,"YOR285W":null},"has_protein_features":false,"name":"RDL1","ortholog_annotations":[{"gene_uniquename":"YOR285W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01239","reference_uniquename":"PMID:29761456"}],"product":"Thiosulfate sulfurtransferase; contains a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress; similar to the human TSTD gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR285W"}


id: YOR286W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01239":null,"YOR286W":null},"has_protein_features":false,"name":"RDL2","ortholog_annotations":[{"gene_uniquename":"YOR286W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01239","reference_uniquename":"PMID:29761456"}],"product":"Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR286W"}


id: YOR287C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04979":null,"YOR287C":null},"has_protein_features":false,"name":"RRP36","ortholog_annotations":[{"gene_uniquename":"YOR287C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04979","reference_uniquename":"PMID:29761456"}],"product":"Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005813","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR287C"}


id: YOR288C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04046":null,"YOR288C":null},"has_protein_features":false,"name":"MPD1","ortholog_annotations":[{"gene_uniquename":"YOR288C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04046","reference_uniquename":"PMID:29761456"}],"product":"Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005814","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR288C"}


id: YOR289W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05222":null,"YOR289W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR289W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05222","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005815","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR289W"}


id: YOR290C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04755":null,"SJAG_05313":null,"YOR290C":null},"has_protein_features":false,"name":"SNF2","ortholog_annotations":[{"gene_uniquename":"YOR290C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04755","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR290C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05313","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005816","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR290C"}


id: YOR291W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03866":null,"SJAG_04757":null,"YOR291W":null},"has_protein_features":false,"name":"YPK9","ortholog_annotations":[{"gene_uniquename":"YOR291W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03866","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR291W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04757","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar protein with a possible role in sequestering heavy metals; involved in the oxidative stress response and modulation of replicative lifespan; undergoes autophosphorylation, which is abolished by mutation of Asp781 in the catalytic motif (D781N); P5 ATPase subfamily member with similarity to yeast Spf1p and homology of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005817","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR291W"}


id: YOR292C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00631":null,"SJAG_01649":null,"YOR292C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR292C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00631","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOR292C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01649","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005818","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR292C"}


id: YOR293C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028858","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR293C-A"}


id: YOR293W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02904":null,"SJAG_04695":null,"YOR293W":null},"has_protein_features":false,"name":"RPS10A","ortholog_annotations":[{"gene_uniquename":"YOR293W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02904","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR293W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04695","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication; mutations in the human homolog associated with Diamond-Blackfan anemia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005819","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR293W"}


id: YOR294W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02644":null,"YOR294W":null},"has_protein_features":false,"name":"RRS1","ortholog_annotations":[{"gene_uniquename":"YOR294W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02644","reference_uniquename":"PMID:29761456"}],"product":"Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005820","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR294W"}


id: YOR295W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02747":null,"YOR295W":null},"has_protein_features":false,"name":"UAF30","ortholog_annotations":[{"gene_uniquename":"YOR295W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02747","reference_uniquename":"PMID:29761456"}],"product":"Subunit of UAF (upstream activation factor) complex; UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; targeting factor for the UAF that facilitates activation of many rDNA genes; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005821","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR295W"}


id: YOR296W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00472":null,"SJAG_02572":null,"YOR296W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR296W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00472","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOR296W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02572","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005822","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR296W"}


id: YOR297C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02398":null,"YOR297C":null},"has_protein_features":false,"name":"TIM18","ortholog_annotations":[{"gene_uniquename":"YOR297C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02398","reference_uniquename":"PMID:29761456"}],"product":"Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005823","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR297C"}


id: YOR298C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00269":null,"YOR298C-A":null},"has_protein_features":false,"name":"MBF1","ortholog_annotations":[{"gene_uniquename":"YOR298C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00269","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR298C-A"}


id: YOR298W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MUM3","product":"Protein of unknown function involved in outer spore wall organization; has similarity to the tafazzins superfamily of acyltransferases","secondary_identifier":"SGD:S000005824","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR298W"}


id: YOR299W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00916":null,"YOR299W":null},"has_protein_features":false,"name":"BUD7","ortholog_annotations":[{"gene_uniquename":"YOR299W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00916","reference_uniquename":"PMID:29761456"}],"product":"Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005825","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR299W"}


id: YOR300W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7","secondary_identifier":"SGD:S000005826","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR300W"}


id: YOR301W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00745":null,"YOR301W":null},"has_protein_features":false,"name":"RAX1","ortholog_annotations":[{"gene_uniquename":"YOR301W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00745","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in establishing bud site selection; localizes to the bud neck and previous sites of cell division (bud scars or cytokinesis remnants (CRMs); localization to both sites is interdependent with Rax2p; required with Rax2p to anchor Nba1p and Nis1p to CRMs where a Cdc42p inhibitory zone is established, preventing repolarization of cells at previous division sites; predicted type IIIa transmembrane protein with similarity to members of the insulin-related peptide superfamily","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005827","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR301W"}


id: YOR302W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"CPA1 uORF; Arginine attenuator peptide, regulates translation of the CPA1 mRNA","secondary_identifier":"SGD:S000005828","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR302W"}


id: YOR303W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00392":null,"YOR303W":null},"has_protein_features":false,"name":"CPA1","ortholog_annotations":[{"gene_uniquename":"YOR303W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00392","reference_uniquename":"PMID:29761456"}],"product":"Small subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005829","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR303W"}


id: YOR304C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BIL1","product":"Protein that binds Bud6p and has a role in actin cable assembly; involved in the Bnr1p-dependent pathway of cable assembly; localizes to bud tip and bud neck","secondary_identifier":"SGD:S000005830","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR304C-A"}


id: YOR304W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ISW2","product":"ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth; exhibits basal levels of chromatin binding throughout the genome as well as interacts with sequence-specific factors to accurately position nucleosomes in chromatin; targeted by Ume6p- and Sua7p-dependent DNA looping to many loci genome-wide","secondary_identifier":"SGD:S000005831","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR304W"}


id: YOR305W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01569":null,"YOR305W":null},"has_protein_features":false,"name":"RRG7","ortholog_annotations":[{"gene_uniquename":"YOR305W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01569","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005832","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR305W"}


id: YOR306C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MCH5","product":"Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport","secondary_identifier":"SGD:S000005833","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR306C"}


id: YOR307C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00276":null,"YOR307C":null},"has_protein_features":false,"name":"SLY41","ortholog_annotations":[{"gene_uniquename":"YOR307C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00276","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in ER-to-Golgi transport; packaged into COPII vesicles for trafficking between ER and Golgi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005834","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR307C"}


id: YOR308C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04433":null,"YOR308C":null},"has_protein_features":false,"name":"SNU66","ortholog_annotations":[{"gene_uniquename":"YOR308C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04433","reference_uniquename":"PMID:29761456"}],"product":"Component of the U4/U6.U5 snRNP complex; involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005835","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR308C"}


id: YOR309C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58","secondary_identifier":"SGD:S000005836","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR309C"}


id: YOR310C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00744":null,"YOR310C":null},"has_protein_features":false,"name":"NOP58","ortholog_annotations":[{"gene_uniquename":"YOR310C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00744","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in producing mature rRNAs and snoRNAs; involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005837","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR310C"}


id: YOR311C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04883":null,"YOR311C":null},"has_protein_features":false,"name":"DGK1","ortholog_annotations":[{"gene_uniquename":"YOR311C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04883","reference_uniquename":"PMID:29761456"}],"product":"Diacylglycerol kinase; localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005838","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR311C"}


id: YOR312C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02283":null,"SJAG_04897":null,"YOR312C":null},"has_protein_features":false,"name":"RPL20B","ortholog_annotations":[{"gene_uniquename":"YOR312C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02283","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR312C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04897","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005839","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR312C"}


id: YOR313C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPS4","product":"Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage","secondary_identifier":"SGD:S000005840","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR313C"}


id: YOR314W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000005841","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR314W"}


id: YOR314W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR314W-A"}


id: YOR315W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SFG1","product":"Nuclear protein putative transcription factor; required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate","secondary_identifier":"SGD:S000005842","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR315W"}


id: YOR316C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01078":null,"SJAG_01803":null,"YOR316C":null},"has_protein_features":false,"name":"COT1","ortholog_annotations":[{"gene_uniquename":"YOR316C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01078","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR316C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01803","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005843","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR316C"}


id: YOR316C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028584","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR316C-A"}


id: YOR317W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03471":null,"SJAG_03909":null,"YOR317W":null},"has_protein_features":false,"name":"FAA1","ortholog_annotations":[{"gene_uniquename":"YOR317W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03471","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR317W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03909","reference_uniquename":"PMID:29761456"}],"product":"Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatty acids and sphingoid long-chain bases; accounts for most acyl-CoA synthetase activity; localizes to lipid particles and the plasma membrane; role in sphingolipid-to-glycerolipid metabolism; forms ER foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6, SLC27A2, or 4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005844","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR317W"}


id: YOR318C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo","secondary_identifier":"SGD:S000005845","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR318C"}


id: YOR319W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00504":null,"YOR319W":null},"has_protein_features":false,"name":"HSH49","ortholog_annotations":[{"gene_uniquename":"YOR319W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00504","reference_uniquename":"PMID:29761456"}],"product":"U2-snRNP associated splicing factor; similar to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005846","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR319W"}


id: YOR320C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03149":null,"SJAG_03150":null,"YOR320C":null},"has_protein_features":false,"name":"GNT1","ortholog_annotations":[{"gene_uniquename":"YOR320C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR320C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03150","reference_uniquename":"PMID:29761456"}],"product":"N-acetylglucosaminyltransferase; capable of modification of N-linked glycans in the Golgi apparatus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005847","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR320C"}


id: YOR321W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04053":null,"YOR321W":null},"has_protein_features":false,"name":"PMT3","ortholog_annotations":[{"gene_uniquename":"YOR321W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04053","reference_uniquename":"PMID:29761456"}],"product":"Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005848","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR321W"}


id: YOR322C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02789":null,"SJAG_03404":null,"YOR322C":null},"has_protein_features":false,"name":"LDB19","ortholog_annotations":[{"gene_uniquename":"YOR322C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02789","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR322C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03404","reference_uniquename":"PMID:29761456"}],"product":"Alpha-arrestin, Ub-ligase adaptor for Rsp5p; regulates starvation- and substrate-induced Ub-dependent endocytosis of select plasma membrane localized amino acid transporters, recruiting Rsp5p to its targets; role in basal internalization and turnover of Ste2p, mating and zygote formation; recruits Rsp5p to Ste2p via its 2 PPXY motifs; inhibited by Npr1p-mediated phosphorylation, affecting cytosol and plasma membrane translocation; localization regulated by Rsp5p-dependent ubiquitination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005849","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR322C"}


id: YOR323C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00660":null,"YOR323C":null},"has_protein_features":false,"name":"PRO2","ortholog_annotations":[{"gene_uniquename":"YOR323C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00660","reference_uniquename":"PMID:29761456"}],"product":"Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005850","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR323C"}


id: YOR324C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FRT1","product":"Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005851","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR324C"}


id: YOR325W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1","secondary_identifier":"SGD:S000005852","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR325W"}


id: YOR326W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00938":null,"SJAG_03011":null,"YOR326W":null},"has_protein_features":false,"name":"MYO2","ortholog_annotations":[{"gene_uniquename":"YOR326W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00938","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR326W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03011","reference_uniquename":"PMID:29761456"}],"product":"Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, lipid droplets, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005853","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR326W"}


id: YOR327C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02241":null,"YOR327C":null},"has_protein_features":false,"name":"SNC2","ortholog_annotations":[{"gene_uniquename":"YOR327C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02241","reference_uniquename":"PMID:29761456"}],"product":"Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; Snc2p levels regulated by Vps45p; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005854","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR327C"}


id: YOR328W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04277":null,"YOR328W":null},"has_protein_features":false,"name":"PDR10","ortholog_annotations":[{"gene_uniquename":"YOR328W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"ATP-binding cassette (ABC) transporter; multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005855","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR328W"}


id: YOR329C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SCD5","product":"Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency","secondary_identifier":"SGD:S000005856","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR329C"}


id: YOR329W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028585","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR329W-A"}


id: YOR330C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02658":null,"YOR330C":null},"has_protein_features":false,"name":"MIP1","ortholog_annotations":[{"gene_uniquename":"YOR330C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02658","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial DNA polymerase gamma; single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoan complex of catalytic and accessory subunits; polymorphic in yeast, petites occur more frequently in some lab strains; human ortholog POLG complements yeast mip1 mutant; mutations in human POLG associated with Alpers-Huttenlocher syndrome (AHS), progressive external ophthalmoplegia (PEO), parkinsonism, other mitochondrial diseases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005857","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR330C"}


id: YOR331C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W","secondary_identifier":"SGD:S000005858","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR331C"}


id: YOR332W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00212":null,"YOR332W":null},"has_protein_features":false,"name":"VMA4","ortholog_annotations":[{"gene_uniquename":"YOR332W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00212","reference_uniquename":"PMID:29761456"}],"product":"Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005859","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR332W"}


id: YOR333C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of MRS2 gene required for respiratory growth","secondary_identifier":"SGD:S000005860","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR333C"}


id: YOR334W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01639":null,"YOR334W":null},"has_protein_features":false,"name":"MRS2","ortholog_annotations":[{"gene_uniquename":"YOR334W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01639","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; similar to bacterial CorA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005861","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR334W"}


id: YOR335C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01797":null,"YOR335C":null},"has_protein_features":false,"name":"ALA1","ortholog_annotations":[{"gene_uniquename":"YOR335C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01797","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic and mitochondrial alanyl-tRNA synthetase; required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog AARS; mutations in human homolog AARS are associated with autoimmune disease polymyositis/dermatomyositis and with hereditary peripheral neuropathy, Charcot-Marie-Tooth (CMT) disease","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005862","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR335C"}


id: YOR335W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ALA1/YOR335C","secondary_identifier":"SGD:S000028717","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR335W-A"}


id: YOR336W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04571":null,"YOR336W":null},"has_protein_features":false,"name":"KRE5","ortholog_annotations":[{"gene_uniquename":"YOR336W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04571","reference_uniquename":"PMID:29761456"}],"product":"Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005863","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR336W"}


id: YOR337W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05337":null,"YOR337W":null},"has_protein_features":false,"name":"TEA1","ortholog_annotations":[{"gene_uniquename":"YOR337W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05337","reference_uniquename":"PMID:29761456"}],"product":"Ty1 enhancer activator involved in Ty enhancer-mediated transcription; required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005864","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR337W"}


id: YOR338W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03441":null,"YOR338W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR338W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03441","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005865","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR338W"}


id: YOR339C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01679":null,"YOR339C":null},"has_protein_features":false,"name":"UBC11","ortholog_annotations":[{"gene_uniquename":"YOR339C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01679","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-conjugating enzyme; most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005866","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR339C"}


id: YOR340C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01562":null,"YOR340C":null},"has_protein_features":false,"name":"RPA43","ortholog_annotations":[{"gene_uniquename":"YOR340C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01562","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase I subunit A43","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005867","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR340C"}


id: YOR341W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03144":null,"YOR341W":null},"has_protein_features":false,"name":"RPA190","ortholog_annotations":[{"gene_uniquename":"YOR341W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03144","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase I largest subunit A190","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005868","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR341W"}


id: YOR342C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005869","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR342C"}


id: YOR343C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000005870","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR343C"}


id: YOR344C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TYE7","product":"Serine-rich protein that contains a bHLH DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression; bHLH stands for basic-helix-loop-helix","secondary_identifier":"SGD:S000005871","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR344C"}


id: YOR345C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2","secondary_identifier":"SGD:S000005872","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR345C"}


id: YOR346W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03906":null,"YOR346W":null},"has_protein_features":false,"name":"REV1","ortholog_annotations":[{"gene_uniquename":"YOR346W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03906","reference_uniquename":"PMID:29761456"}],"product":"Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress; may be involved in meiosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005873","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR346W"}


id: YOR347C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02796":null,"YOR347C":null},"has_protein_features":false,"name":"PYK2","ortholog_annotations":[{"gene_uniquename":"YOR347C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02796","reference_uniquename":"PMID:29761456"}],"product":"Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005874","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR347C"}


id: YOR348C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04718":null,"YOR348C":null},"has_protein_features":false,"name":"PUT4","ortholog_annotations":[{"gene_uniquename":"YOR348C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04718","reference_uniquename":"PMID:29761456"}],"product":"Proline permease; required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005875","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR348C"}


id: YOR349W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04074":null,"YOR349W":null},"has_protein_features":false,"name":"CIN1","ortholog_annotations":[{"gene_uniquename":"YOR349W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04074","reference_uniquename":"PMID:29761456"}],"product":"Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005876","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR349W"}


id: YOR350C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MNE1","product":"Protein involved in splicing Group I aI5-beta intron from COX1 mRNA; mitochondrial matrix protein","secondary_identifier":"SGD:S000005877","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR350C"}


id: YOR351C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03438":null,"YOR351C":null},"has_protein_features":false,"name":"MEK1","ortholog_annotations":[{"gene_uniquename":"YOR351C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03438","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific serine/threonine protein kinase; functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids; stabilizes Hop1-Thr318 phosphorylation to promote interhomolog recombination and checkpoint responses during meiosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005878","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR351C"}


id: YOR352W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04420":null,"YOR352W":null},"has_protein_features":false,"name":"TFB6","ortholog_annotations":[{"gene_uniquename":"YOR352W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04420","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005879","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR352W"}


id: YOR353C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00317":null,"YOR353C":null},"has_protein_features":false,"name":"SOG2","ortholog_annotations":[{"gene_uniquename":"YOR353C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00317","reference_uniquename":"PMID:29761456"}],"product":"Key component of the RAM signaling network; required for proper cell morphogenesis and cell separation after mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005880","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR353C"}


id: YOR354C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MSC6","product":"Multicopy suppressor of HER2 involved in mitochondrial translation; mutant is defective in directing meiotic recombination events to homologous chromatids","secondary_identifier":"SGD:S000005881","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR354C"}


id: YOR355W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GDS1","product":"Protein involved in histone H4 acetylation at ribosomal protein genes; interacts with and modulates NuA4 histone acetyltransferase complex; required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a segment predicted to resemble the winged-helix/forkhead domain located in DNA-binding proteins","secondary_identifier":"SGD:S000005882","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR355W"}


id: YOR356W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CIR2","product":"Putative ortholog of human ETF-dH; found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response; ETF-dH is also known as electron transfer flavoprotein dehydrogenase","secondary_identifier":"SGD:S000005883","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR356W"}


id: YOR357C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00314":null,"YOR357C":null},"has_protein_features":false,"name":"SNX3","ortholog_annotations":[{"gene_uniquename":"YOR357C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00314","reference_uniquename":"PMID:29761456"}],"product":"Sorting nexin for late-Golgi enzymes; required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005884","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR357C"}


id: YOR358W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01062":null,"YOR358W":null},"has_protein_features":false,"name":"HAP5","ortholog_annotations":[{"gene_uniquename":"YOR358W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01062","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005885","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR358W"}


id: YOR359W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03113":null,"YOR359W":null},"has_protein_features":false,"name":"VTS1","ortholog_annotations":[{"gene_uniquename":"YOR359W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03113","reference_uniquename":"PMID:29761456"}],"product":"Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif (SAM) domain that interacts with Smg recognition element (SREs) containing transcripts; stimulates Dna2p endonuclease activity; forms [SMAUG+] prion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005886","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR359W"}


id: YOR360C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PDE2","product":"High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon","secondary_identifier":"SGD:S000005887","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR360C"}


id: YOR361C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04744":null,"YOR361C":null},"has_protein_features":false,"name":"PRT1","ortholog_annotations":[{"gene_uniquename":"YOR361C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04744","reference_uniquename":"PMID:29761456"}],"product":"eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes; eIF3 is also involved in programmed stop codon readthrough","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005888","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR361C"}


id: YOR362C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00778":null,"YOR362C":null},"has_protein_features":false,"name":"PRE10","ortholog_annotations":[{"gene_uniquename":"YOR362C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00778","reference_uniquename":"PMID:29761456"}],"product":"Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005889","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR362C"}


id: YOR363C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PIP2","product":"Autoregulatory, oleate-activated transcription factor; subunit of a heterodimeric complex with Oaf1p, which binds to oleate-response elements (ORE) in the promoter of genes involved in beta-oxidation of fatty acids, peroxisome organization and biogenesis, activating transcription in the presence of oleate; PIP2 has a paralog, OAF1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005890","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR363C"}


id: YOR364W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C","secondary_identifier":"SGD:S000005891","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR364W"}


id: YOR365C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02727":null,"SJAG_04668":null,"YOR365C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR365C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02727","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR365C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04668","reference_uniquename":"PMID:29761456"}],"product":"Putative protein involved in sphingolipid biosynthesis; not an essential gene; YOR365C has a paralog, FLC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005892","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR365C"}


id: YOR366W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C","secondary_identifier":"SGD:S000005893","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR366W"}


id: YOR367W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SCP1","product":"Component of yeast cortical actin cytoskeleton; binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin","secondary_identifier":"SGD:S000005894","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR367W"}


id: YOR368W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02771":null,"YOR368W":null},"has_protein_features":false,"name":"RAD17","ortholog_annotations":[{"gene_uniquename":"YOR368W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02771","reference_uniquename":"PMID:29761456"}],"product":"Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005895","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR368W"}


id: YOR369C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03262":null,"YOR369C":null},"has_protein_features":false,"name":"RPS12","ortholog_annotations":[{"gene_uniquename":"YOR369C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03262","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005896","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR369C"}


id: YOR370C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02063":null,"YOR370C":null},"has_protein_features":false,"name":"MRS6","ortholog_annotations":[{"gene_uniquename":"YOR370C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02063","reference_uniquename":"PMID:29761456"}],"product":"Rab escort protein; type II geranylgeranyltransferase complex (Bet2p-Bet4p) chaperone that complexes with newly synthesized Rab GTPases, like Ypt1p and Sec4p, leading to their prenylation and membrane delivery; modulates the TOR pathway through interactions with Sfp1p; alters the kinetics of MAPK pathway activation and polarity reorganization during filamentous growth; sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005897","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR370C"}


id: YOR371C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GPB1","product":"Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005898","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR371C"}


id: YOR372C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NDD1","product":"Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes; turnover is tightly regulated during cell cycle and in response to DNA damage","secondary_identifier":"SGD:S000005899","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR372C"}


id: YOR373W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01188":null,"YOR373W":null},"has_protein_features":false,"name":"NUD1","ortholog_annotations":[{"gene_uniquename":"YOR373W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01188","reference_uniquename":"PMID:29761456"}],"product":"Mitotic exit network (MEN) scaffold protein; core component of the SPB outer plaque that functions in astral microtubule organization via Spc72p; scaffold for recruitment of MEN components, such as Cdc15p, Tem1p and the Bfa1p-Bub2p checkpoint complex; phosphorylation by Cdc15p creates a Dbf2p-Mob1p phospho-docking site enabling Cdc15p-dependent complex activation and mitotic exit; acts through the MEN to specify Kar9p-mediated asymmetric SPB inheritance; homologous to mammalian centriolin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005900","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR373W"}


id: YOR374W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03786":null,"YOR374W":null},"has_protein_features":false,"name":"ALD4","ortholog_annotations":[{"gene_uniquename":"YOR374W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03786","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial aldehyde dehydrogenase; required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed; can substitute for cytosolic NADP-dependent aldehyde dehydrogenase when directed to the cytosol; human homolog ALDH2 can complement yeast ald4 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005901","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR374W"}


id: YOR375C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03266":null,"YOR375C":null},"has_protein_features":false,"name":"GDH1","ortholog_annotations":[{"gene_uniquename":"YOR375C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03266","reference_uniquename":"PMID:29761456"}],"product":"NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005902","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR375C"}


id: YOR376W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YOR376W is not an essential gene","secondary_identifier":"SGD:S000005903","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR376W"}


id: YOR376W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028586","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR376W-A"}


id: YOR377W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATF1","product":"Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism","secondary_identifier":"SGD:S000005904","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR377W"}


id: YOR378W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AMF1","product":"Low affinity NH4+ transporter; member of the DHA2 family of drug:H+ anti porters; putative paralog of ATR1; but not required for boron tolerance; non-essential gene","secondary_identifier":"SGD:S000005905","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR378W"}


id: YOR379C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W","secondary_identifier":"SGD:S000005906","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR379C"}


id: YOR380W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RDR1","product":"Transcriptional repressor involved in regulating multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins","secondary_identifier":"SGD:S000005907","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR380W"}


id: YOR381W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04743":null,"YOR381W":null},"has_protein_features":false,"name":"FRE3","ortholog_annotations":[{"gene_uniquename":"YOR381W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Ferric reductase; reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005908","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR381W"}


id: YOR381W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR381W-A"}


id: YOR382W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FIT2","product":"Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall","secondary_identifier":"SGD:S000005909","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR382W"}


id: YOR383C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FIT3","product":"Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall","secondary_identifier":"SGD:S000005910","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR383C"}


id: YOR384W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04743":null,"YOR384W":null},"has_protein_features":false,"name":"FRE5","ortholog_annotations":[{"gene_uniquename":"YOR384W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005911","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR384W"}


id: YOR385W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene","secondary_identifier":"SGD:S000005912","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR385W"}


id: YOR386W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PHR1","product":"DNA photolyase involved in photoreactivation; repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p","secondary_identifier":"SGD:S000005913","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR386W"}


id: YOR387C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00161":null,"YOR387C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR387C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00161","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YOR387C has a paralog, VEL1, that arose from a single-locus duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005914","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR387C"}


id: YOR388C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FDH1","product":"NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate","secondary_identifier":"SGD:S000005915","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR388C"}


id: YOR389W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; expression regulated by copper levels","secondary_identifier":"SGD:S000005916","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR389W"}


id: YOR390W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01973":null,"YOR390W":null},"has_protein_features":false,"name":"FEX1","ortholog_annotations":[{"gene_uniquename":"YOR390W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01973","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in fluoride export; nearly identical to FEX2, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX domains connected by a linker; part of a widespread family of conserved fluoride export proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005917","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR390W"}


id: YOR391C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02988":null,"SJAG_04674":null,"YOR391C":null},"has_protein_features":false,"name":"HSP33","ortholog_annotations":[{"gene_uniquename":"YOR391C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02988","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR391C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04674","reference_uniquename":"PMID:29761456"}],"product":"Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005918","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR391C"}


id: YOR392W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; gene expression induced by heat","secondary_identifier":"SGD:S000005919","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR392W"}


id: YOR393W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00461":null,"SJAG_02107":null,"SJAG_02369":null,"YOR393W":null},"has_protein_features":false,"name":"ERR1","ortholog_annotations":[{"gene_uniquename":"YOR393W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00461","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR393W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02107","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR393W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02369","reference_uniquename":"PMID:29761456"}],"product":"Putative phosphopyruvate hydratase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005920","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR393W"}


id: YOR394C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028718","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR394C-A"}


id: YOR394W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU21","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cytosol; identical to Pau22p; encodes two proteins that are translated from 2 different start codons","secondary_identifier":"SGD:S000005921","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR394W"}


id: YOR396C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028719","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR396C-A"}


id: YOR396W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YRF1-8","product":"One of several telomeric Y' element-encoded DNA helicases; known as Y'-Help1 (Y'-HELicase Protein 1)","secondary_identifier":"SGD:S000007526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR396W"}


id: YPL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00676":null,"YPL001W":null},"has_protein_features":false,"name":"HAT1","ortholog_annotations":[{"gene_uniquename":"YPL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00676","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex; uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005922","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL001W"}


id: YPL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04936":null,"YPL002C":null},"has_protein_features":false,"name":"SNF8","ortholog_annotations":[{"gene_uniquename":"YPL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04936","reference_uniquename":"PMID:29761456"}],"product":"Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005923","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL002C"}


id: YPL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03950":null,"YPL003W":null},"has_protein_features":false,"name":"ULA1","ortholog_annotations":[{"gene_uniquename":"YPL003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03950","reference_uniquename":"PMID:29761456"}],"product":"Protein that activates Rub1p (NEDD8) before neddylation; acts together with Uba3p; may play a role in protein degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005924","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL003W"}


id: YPL004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02626":null,"SJAG_02707":null,"YPL004C":null},"has_protein_features":false,"name":"LSP1","ortholog_annotations":[{"gene_uniquename":"YPL004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02626","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02707","reference_uniquename":"PMID:29761456"}],"product":"Eisosome core component; eisosomes are large immobile patch structures at the cell cortex associated with endocytosis; phosphorylated on Thr233 upon Pkc1p hyperactivation in a Slt2p MAPK-dependent fashion; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005925","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL004C"}


id: YPL005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AEP3","product":"Peripheral mitochondrial inner membrane protein; may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; stabilizes the bicistronic AAP1-ATP6 mRNA","secondary_identifier":"SGD:S000005926","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL005W"}


id: YPL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NCR1","product":"Vacuolar membrane protein involved with Npc2p in sterol trafficking; transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCB), similar to the accumulation of high amounts of lipids observed in patients with Neimann-Pick C, a disease caused by loss-of-function mutations in NPC1, the functional ortholog of Ncr1p","secondary_identifier":"SGD:S000005927","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL006W"}


id: YPL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03546":null,"YPL007C":null},"has_protein_features":false,"name":"TFC8","ortholog_annotations":[{"gene_uniquename":"YPL007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03546","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005928","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL007C"}


id: YPL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01644":null,"YPL008W":null},"has_protein_features":false,"name":"CHL1","ortholog_annotations":[{"gene_uniquename":"YPL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01644","reference_uniquename":"PMID:29761456"}],"product":"Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005929","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL008W"}


id: YPL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01074":null,"YPL009C":null},"has_protein_features":false,"name":"RQC2","ortholog_annotations":[{"gene_uniquename":"YPL009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01074","reference_uniquename":"PMID:29761456"}],"product":"Component of the Ribosome Quality Control (RQC) complex;  RQC is a ribosome-bound complex required for degradation of polypeptides arising from stalled translation; recruits alanine- and threonine-charged tRNA to the A site and directs the elongation of nascent chains independently of mRNA or 40S subunits; monitors translation stress and signals this to Hsf1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005930","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL009C"}


id: YPL010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04474":null,"YPL010W":null},"has_protein_features":false,"name":"RET3","ortholog_annotations":[{"gene_uniquename":"YPL010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04474","reference_uniquename":"PMID:29761456"}],"product":"Zeta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005931","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL010W"}


id: YPL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04977":null,"YPL011C":null},"has_protein_features":false,"name":"TAF3","ortholog_annotations":[{"gene_uniquename":"YPL011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04977","reference_uniquename":"PMID:29761456"}],"product":"TFIID subunit (47 kDa); involved in promoter binding and RNA polymerase II transcription initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005932","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL011C"}


id: YPL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01323":null,"SJAG_04687":null,"YPL012W":null},"has_protein_features":false,"name":"RRP12","ortholog_annotations":[{"gene_uniquename":"YPL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01323","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04687","reference_uniquename":"PMID:29761456"}],"product":"Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; also plays a role in the cell cycle and the DNA damage response; contains HEAT-repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005933","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL012W"}


id: YPL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02324":null,"YPL013C":null},"has_protein_features":false,"name":"MRPS16","ortholog_annotations":[{"gene_uniquename":"YPL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02324","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005934","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL013C"}


id: YPL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CIP1","product":"Cyclin-dependent kinase inhibitor; activated by environmental stress; interacts with and inhibits the Cdc28p/Cln2p, G1/S phase cyclin-dependent kinase complex but not S-phase, or M-phase complexes; overexpression blocks cells in G1 phase and stabilizes the Cdc28p inhibitor Sic1p, while disruption accelerates the G1/S phase transition; phosphorylated during S phase in a Cdc28p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus","secondary_identifier":"SGD:S000005935","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL014W"}


id: YPL015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01075":null,"YPL015C":null},"has_protein_features":false,"name":"HST2","ortholog_annotations":[{"gene_uniquename":"YPL015C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01075","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic NAD(+)-dependent protein deacetylase; deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005936","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL015C"}


id: YPL016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02254":null,"YPL016W":null},"has_protein_features":false,"name":"SWI1","ortholog_annotations":[{"gene_uniquename":"YPL016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02254","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; self-assembles to form [SWI+] prion and to alter expression pattern; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005937","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL016W"}


id: YPL017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03290":null,"YPL017C":null},"has_protein_features":false,"name":"IRC15","ortholog_annotations":[{"gene_uniquename":"YPL017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03290","reference_uniquename":"PMID:26896847"}],"product":"Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci; IRC15 has a paralog, LPD1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000005938","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL017C"}


id: YPL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04040":null,"YPL018W":null},"has_protein_features":false,"name":"CTF19","ortholog_annotations":[{"gene_uniquename":"YPL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04040","reference_uniquename":"PMID:29761456"}],"product":"Outer kinetochore protein, needed for accurate chromosome segregation; component of kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as platform for kinetochore assembly; required for spindle assembly checkpoint; minimizes potentially deleterious centromere-proximal crossovers by preventing meiotic DNA break formation proximal to centromere; homolog of human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005939","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL018W"}


id: YPL019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03442":null,"YPL019C":null},"has_protein_features":false,"name":"VTC3","ortholog_annotations":[{"gene_uniquename":"YPL019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03442","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of the vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; VTC3 has a paralog, VTC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005940","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL019C"}


id: YPL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00776":null,"SJAG_02214":null,"YPL020C":null},"has_protein_features":false,"name":"ULP1","ortholog_annotations":[{"gene_uniquename":"YPL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00776","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02214","reference_uniquename":"PMID:29761456"}],"product":"Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; contributes to regulation of telomeric silencing; sequestered to the nucleolus under stress conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005941","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL020C"}


id: YPL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ECM23","product":"Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p","secondary_identifier":"SGD:S000005942","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL021W"}


id: YPL022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02556":null,"YPL022W":null},"has_protein_features":false,"name":"RAD1","ortholog_annotations":[{"gene_uniquename":"YPL022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02556","reference_uniquename":"PMID:29761456"}],"product":"Single-stranded DNA endonuclease (with Rad10p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005943","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL022W"}


id: YPL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01466":null,"YPL023C":null},"has_protein_features":false,"name":"MET12","ortholog_annotations":[{"gene_uniquename":"YPL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01466","reference_uniquename":"PMID:29761456"}],"product":"Protein with MTHFR activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of methylenetetrahydrofolate reductase (MTHFR)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005944","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL023C"}


id: YPL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02262":null,"YPL024W":null},"has_protein_features":false,"name":"RMI1","ortholog_annotations":[{"gene_uniquename":"YPL024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02262","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing, DNA catenation/decatenation and ssDNA binding activities of Top3p; involved in response to DNA damage; functions in S phase-mediated cohesion establishment via a pathway involving the Ctf18-RFC complex and Mrc1p; stimulates Top3p DNA catenation/decatenation activity; null mutants display increased rates of recombination and delayed S phase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005945","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL024W"}


id: YPL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005946","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL025C"}


id: YPL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01311":null,"YPL026C":null},"has_protein_features":false,"name":"SKS1","ortholog_annotations":[{"gene_uniquename":"YPL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01311","reference_uniquename":"PMID:29761456"}],"product":"Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway; SKS1 has a paralog, VHS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005947","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL026C"}


id: YPL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SMA1","product":"Protein of unknown function involved in prospore membrane assembly; involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p","secondary_identifier":"SGD:S000005948","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL027W"}


id: YPL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00413":null,"YPL028W":null},"has_protein_features":false,"name":"ERG10","ortholog_annotations":[{"gene_uniquename":"YPL028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00413","reference_uniquename":"PMID:29761456"}],"product":"Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase); cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis; human ACAT1 functionally complements the growth defect caused by repression of ERG10 expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005949","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL028W"}


id: YPL029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02991":null,"YPL029W":null},"has_protein_features":false,"name":"SUV3","ortholog_annotations":[{"gene_uniquename":"YPL029W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02991","reference_uniquename":"PMID:29761456"}],"product":"ATP-dependent RNA helicase; component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron; expression of a processed form of human homolog SUPV3L1 carrying an N-terminal deletion of 46 amino acids rescues yeast suv3 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005950","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL029W"}


id: YPL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03367":null,"YPL030W":null},"has_protein_features":false,"name":"TRM44","ortholog_annotations":[{"gene_uniquename":"YPL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03367","reference_uniquename":"PMID:29761456"}],"product":"tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005951","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL030W"}


id: YPL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01825":null,"YPL031C":null},"has_protein_features":false,"name":"PHO85","ortholog_annotations":[{"gene_uniquename":"YPL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01825","reference_uniquename":"PMID:29761456"}],"product":"Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissencephaly-associated homolog CDK5 functionally complements null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005952","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL031C"}


id: YPL032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02729":null,"SJAG_04591":null,"YPL032C":null},"has_protein_features":false,"name":"SVL3","ortholog_annotations":[{"gene_uniquename":"YPL032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02729","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04591","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress; SVL3 has a paralog, PAM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005953","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL032C"}


id: YPL033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SRL4","product":"Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p","secondary_identifier":"SGD:S000005954","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL033C"}


id: YPL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01350":null,"YPL034W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01350","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; YPL034W is not essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005955","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL034W"}


id: YPL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene","secondary_identifier":"SGD:S000005956","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL035C"}


id: YPL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01129":null,"SJAG_01669":null,"SJAG_04258":null,"YPL036W":null},"has_protein_features":false,"name":"PMA2","ortholog_annotations":[{"gene_uniquename":"YPL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01129","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01669","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04258","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane H+-ATPase; isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005957","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL036W"}


id: YPL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01733":null,"YPL037C":null},"has_protein_features":false,"name":"EGD1","ortholog_annotations":[{"gene_uniquename":"YPL037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01733","reference_uniquename":"PMID:29761456"}],"product":"Subunit beta1 of the nascent polypeptide-associated complex (NAC); involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b; EGD1 has a paralog, BTT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005958","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL037C"}


id: YPL038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MET31","product":"Zinc-finger DNA-binding transcription factor; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; involved in transcriptional regulation of the methionine biosynthetic genes; feedforward loop controlling expression of MET32 and the lack of such a loop for MET31 may account for the differential actions of Met31p and Met32p; MET31 has a paralog, MET32, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005959","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL038W"}


id: YPL038W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028588","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL038W-A"}


id: YPL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YPL039W is not an essential gene","secondary_identifier":"SGD:S000005960","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL039W"}


id: YPL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04285":null,"YPL040C":null},"has_protein_features":false,"name":"ISM1","ortholog_annotations":[{"gene_uniquename":"YPL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04285","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial isoleucyl-tRNA synthetase; null mutant is deficient in respiratory growth; human homolog IARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005961","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL040C"}


id: YPL041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MRX11","product":"Protein that associates with mitochondrial ribosome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; involved in maintenance of telomere length","secondary_identifier":"SGD:S000005962","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL041C"}


id: YPL042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00342":null,"YPL042C":null},"has_protein_features":false,"name":"SSN3","ortholog_annotations":[{"gene_uniquename":"YPL042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00342","reference_uniquename":"PMID:29761456"}],"product":"Component of the RNA polymerase II mediator complex; cyclin-dependent protein kinase involved in phosphorylation of the mediator component Pgd1p and suppression of transcription activation by RNA polymerase II; involved in glucose repression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005963","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL042C"}


id: YPL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02829":null,"YPL043W":null},"has_protein_features":false,"name":"NOP4","ortholog_annotations":[{"gene_uniquename":"YPL043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02829","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs); human ortholog RBM28 implicated in ANE syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005964","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL043W"}


id: YPL044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W","secondary_identifier":"SGD:S000005965","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL044C"}


id: YPL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01598":null,"YPL045W":null},"has_protein_features":false,"name":"VPS16","ortholog_annotations":[{"gene_uniquename":"YPL045W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01598","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the HOPS and the CORVET complexes; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005966","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL045W"}


id: YPL046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03211":null,"YPL046C":null},"has_protein_features":false,"name":"ELC1","ortholog_annotations":[{"gene_uniquename":"YPL046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03211","reference_uniquename":"PMID:29761456"}],"product":"Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005967","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL046C"}


id: YPL047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03599":null,"YPL047W":null},"has_protein_features":false,"name":"SGF11","ortholog_annotations":[{"gene_uniquename":"YPL047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03599","reference_uniquename":"PMID:29761456"}],"product":"Integral subunit of SAGA histone acetyltransferase complex; regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005968","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL047W"}


id: YPL048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02017":null,"SJAG_03863":null,"YPL048W":null},"has_protein_features":false,"name":"CAM1","ortholog_annotations":[{"gene_uniquename":"YPL048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02017","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03863","reference_uniquename":"PMID:29761456"}],"product":"One of two isoforms of the gamma subunit of eEF1B; stimulates the release of GDP from eEF1A (Tef1p/Tef2p) post association with the ribosomal complex with eEF1Balpha subunit; nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005969","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL048W"}


id: YPL049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DIG1","product":"MAP kinase-responsive inhibitor of the Ste12p transcription factor; involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p; DIG1 has a paralog, DIG2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005970","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL049C"}


id: YPL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01276":null,"YPL050C":null},"has_protein_features":false,"name":"MNN9","ortholog_annotations":[{"gene_uniquename":"YPL050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01276","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Golgi mannosyltransferase complex; this complex mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation; this complex also contains Anp1p, Mnn10p, Mnn11p, and Hoc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005971","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL050C"}


id: YPL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ARL3","product":"ARF-like small GTPase of the RAS superfamily; required for recruitment of Arl1p, a GTPase that regulates membrane traffic, to the Golgi apparatus; NatC-catalyzed N-terminal acetylation regulates Golgi membrane association mediated by interaction with membrane receptor, Sys1p; similar to ADP-ribosylation factor and orthologous to mammalian ARFRP1","secondary_identifier":"SGD:S000005972","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL051W"}


id: YPL052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OAZ1","product":"Regulator of ornithine decarboxylase Spe1p; antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p","secondary_identifier":"SGD:S000005973","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL052W"}


id: YPL052W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YPL052W-A has been demonstrated to be the first exon of downstream ORF OAZ1/YPL052W.","secondary_identifier":"SGD:S000113724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL052W-A"}


id: YPL053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"SJAG_04906":null,"YPL053C":null},"has_protein_features":false,"name":"KTR6","ortholog_annotations":[{"gene_uniquename":"YPL053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04906","reference_uniquename":"PMID:26896847"}],"product":"Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; facilitates the exit of Mnn4p from the ER via COPII-coated vesicles; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005974","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL053C"}


id: YPL054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01535":null,"SJAG_03191":null,"YPL054W":null},"has_protein_features":false,"name":"LEE1","ortholog_annotations":[{"gene_uniquename":"YPL054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01535","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03191","reference_uniquename":"PMID:29761456"}],"product":"Zinc-finger protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005975","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL054W"}


id: YPL055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00320":null,"YPL055C":null},"has_protein_features":false,"name":"LGE1","ortholog_annotations":[{"gene_uniquename":"YPL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00320","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in histone H2B ubiquitination; acts as cofactor for Bre1p; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005976","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL055C"}


id: YPL056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LCL1","product":"Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan","secondary_identifier":"SGD:S000005977","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL056C"}


id: YPL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02168":null,"SJAG_03953":null,"YPL057C":null},"has_protein_features":false,"name":"SUR1","ortholog_annotations":[{"gene_uniquename":"YPL057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02168","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03953","reference_uniquename":"PMID:29761456"}],"product":"Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005978","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL057C"}


id: YPL058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04277":null,"YPL058C":null},"has_protein_features":false,"name":"PDR12","ortholog_annotations":[{"gene_uniquename":"YPL058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane ATP-binding cassette (ABC) transporter; weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005979","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL058C"}


id: YPL059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01417":null,"YPL059W":null},"has_protein_features":false,"name":"GRX5","ortholog_annotations":[{"gene_uniquename":"YPL059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01417","reference_uniquename":"PMID:29761456"}],"product":"Glutathione-dependent oxidoreductase; mitochondrial matrix protein involved at an early step in the biogenesis of iron-sulfur centers along with Bol1p; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005980","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL059W"}


id: YPL060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01639":null,"YPL060W":null},"has_protein_features":false,"name":"MFM1","ortholog_annotations":[{"gene_uniquename":"YPL060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01639","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005981","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL060W"}


id: YPL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03786":null,"YPL061W":null},"has_protein_features":false,"name":"ALD6","ortholog_annotations":[{"gene_uniquename":"YPL061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03786","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic aldehyde dehydrogenase; activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005982","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL061W"}


id: YPL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; deletion decreases transcription of downstream gene ALD6; YPL062W is not an essential gene; null mutant shows decrease in terpenoid production; homozygous diploid mutant shows a decrease in glycogen accumulation","secondary_identifier":"SGD:S000005983","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL062W"}


id: YPL063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03560":null,"YPL063W":null},"has_protein_features":false,"name":"TIM50","ortholog_annotations":[{"gene_uniquename":"YPL063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03560","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the TIM23 complex; acts as receptor for the translocase of the inner mitochondrial membrane (TIM23) complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005984","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL063W"}


id: YPL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00602":null,"YPL064C":null},"has_protein_features":false,"name":"CWC27","ortholog_annotations":[{"gene_uniquename":"YPL064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00602","reference_uniquename":"PMID:29761456"}],"product":"Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005985","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL064C"}


id: YPL065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04349":null,"YPL065W":null},"has_protein_features":false,"name":"VPS28","ortholog_annotations":[{"gene_uniquename":"YPL065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04349","reference_uniquename":"PMID:29761456"}],"product":"Component of the ESCRT-I complex; complex is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p; other members include Stp22p, Srn2p, Vps28p, and Mvb12p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005986","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL065W"}


id: YPL066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02215":null,"YPL066W":null},"has_protein_features":false,"name":"RGL1","ortholog_annotations":[{"gene_uniquename":"YPL066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02215","reference_uniquename":"PMID:29761456"}],"product":"Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005987","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL066W"}


id: YPL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HTC1","product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene","secondary_identifier":"SGD:S000005988","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL067C"}


id: YPL068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000005989","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL068C"}


id: YPL069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BTS1","product":"Geranylgeranyl diphosphate synthase (GGPPS); increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic","secondary_identifier":"SGD:S000005990","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL069C"}


id: YPL070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MUK1","product":"Guanine nucleotide exchange factor (GEF); involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); specifically stimulates the intrinsic guanine nucleotide exchange activity of Rab family members (Vps21p/Ypt52p/Ypt53p); partially redundant with GEF VPS9; required for localization of the CORVET complex to endosomes; contains a VPS9 domain","secondary_identifier":"SGD:S000005991","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL070W"}


id: YPL071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","secondary_identifier":"SGD:S000005992","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL071C"}


id: YPL072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01312":null,"YPL072W":null},"has_protein_features":false,"name":"UBP16","ortholog_annotations":[{"gene_uniquename":"YPL072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01312","reference_uniquename":"PMID:29761456"}],"product":"Deubiquitinating enzyme anchored to the outer mitochondrial membrane; probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005993","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL072W"}


id: YPL073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments","secondary_identifier":"SGD:S000005994","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL073C"}


id: YPL074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01530":null,"SJAG_04566":null,"YPL074W":null},"has_protein_features":false,"name":"YTA6","ortholog_annotations":[{"gene_uniquename":"YPL074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01530","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04566","reference_uniquename":"PMID:29761456"}],"product":"Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005995","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL074W"}


id: YPL075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GCR1","product":"Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p; contains a long intron, which allows multiple RNA and protein isoforms with varying expression levels depending on glucose availability","secondary_identifier":"SGD:S000005996","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL075W"}


id: YPL076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04119":null,"YPL076W":null},"has_protein_features":false,"name":"GPI2","ortholog_annotations":[{"gene_uniquename":"YPL076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04119","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005997","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL076W"}


id: YPL077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005998","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL077C"}


id: YPL078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00836":null,"YPL078C":null},"has_protein_features":false,"name":"ATP4","ortholog_annotations":[{"gene_uniquename":"YPL078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00836","reference_uniquename":"PMID:29761456"}],"product":"Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase; ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex, which in turn determines the shape of inner membrane cristae; phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005999","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL078C"}


id: YPL079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00155":null,"SJAG_01202":null,"YPL079W":null},"has_protein_features":false,"name":"RPL21B","ortholog_annotations":[{"gene_uniquename":"YPL079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00155","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01202","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006000","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL079W"}


id: YPL080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000006001","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL080C"}


id: YPL081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00544":null,"SJAG_04342":null,"YPL081W":null},"has_protein_features":false,"name":"RPS9A","ortholog_annotations":[{"gene_uniquename":"YPL081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00544","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04342","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006002","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL081W"}


id: YPL082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00650":null,"YPL082C":null},"has_protein_features":false,"name":"MOT1","ortholog_annotations":[{"gene_uniquename":"YPL082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00650","reference_uniquename":"PMID:29761456"}],"product":"Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity; may have a role in ensuring that soluble TBP is available to bind TATA-less promoters; forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA; coregulates transcription with Spt16p through assembly of preinitiation complex and organization of nucleosomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006003","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL082C"}


id: YPL083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00754":null,"YPL083C":null},"has_protein_features":false,"name":"SEN54","ortholog_annotations":[{"gene_uniquename":"YPL083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00754","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006004","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL083C"}


id: YPL084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02584":null,"YPL084W":null},"has_protein_features":false,"name":"BRO1","ortholog_annotations":[{"gene_uniquename":"YPL084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02584","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic class E vacuolar protein sorting (VPS) factor; coordinates protein sorting and deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006005","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL084W"}


id: YPL085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00284":null,"YPL085W":null},"has_protein_features":false,"name":"SEC16","ortholog_annotations":[{"gene_uniquename":"YPL085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00284","reference_uniquename":"PMID:29761456"}],"product":"COPII vesicle coat protein required for ER transport vesicle budding; essential factor in endoplasmic reticulum exit site (ERES) formation, as well as in COPII-mediated ER-to-Golgi traffic; bound to periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006006","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL085W"}


id: YPL086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04756":null,"YPL086C":null},"has_protein_features":false,"name":"ELP3","ortholog_annotations":[{"gene_uniquename":"YPL086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04756","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin; human homolog ELP3 can partially complement yeast elp3 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006007","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL086C"}


id: YPL087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YDC1","product":"Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006008","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL087W"}


id: YPL088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative aryl alcohol dehydrogenase; localizes to cytosol; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance","secondary_identifier":"SGD:S000006009","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL088W"}


id: YPL089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02218":null,"SJAG_04191":null,"YPL089C":null},"has_protein_features":false,"name":"RLM1","ortholog_annotations":[{"gene_uniquename":"YPL089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02218","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04191","reference_uniquename":"PMID:29761456"}],"product":"MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006010","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL089C"}


id: YPL090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03034":null,"SJAG_03859":null,"YPL090C":null},"has_protein_features":false,"name":"RPS6A","ortholog_annotations":[{"gene_uniquename":"YPL090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03859","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006011","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL090C"}


id: YPL091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01162":null,"YPL091W":null},"has_protein_features":false,"name":"GLR1","ortholog_annotations":[{"gene_uniquename":"YPL091W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01162","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; cytosolic Glr1p is the main determinant of the glutathione redox state of the mitochondrial intermembrane space; mitochondrial Glr1p has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006012","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL091W"}


id: YPL092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SSU1","product":"Plasma membrane sulfite pump involved in sulfite metabolism; required for efficient sulfite efflux; major facilitator superfamily protein","secondary_identifier":"SGD:S000006013","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL092W"}


id: YPL093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04940":null,"YPL093W":null},"has_protein_features":false,"name":"NOG1","ortholog_annotations":[{"gene_uniquename":"YPL093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04940","reference_uniquename":"PMID:29761456"}],"product":"Putative GTPase; associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006014","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL093W"}


id: YPL094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02588":null,"YPL094C":null},"has_protein_features":false,"name":"SEC62","ortholog_annotations":[{"gene_uniquename":"YPL094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02588","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; cotranslationally N-acetylated by NatA; other members are Sec63p, Sec66p, and Sec72p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006015","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL094C"}


id: YPL095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"EEB1","product":"Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006016","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL095C"}


id: YPL096C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06383":null,"YPL096C-A":null},"has_protein_features":false,"name":"ERI1","ortholog_annotations":[{"gene_uniquename":"YPL096C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06383","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum membrane protein that binds and inhibits Ras2p; binds to and inhibits GTP-bound Ras2p at the endoplasmic reticulum (ER); component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL096C-A"}


id: YPL096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03227":null,"YPL096W":null},"has_protein_features":false,"name":"PNG1","ortholog_annotations":[{"gene_uniquename":"YPL096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03227","reference_uniquename":"PMID:29761456"}],"product":"Conserved peptide N-glycanase; deglycosylating enzyme that cleaves N-glycans that are attached to misfolded ERAD substrate glycoproteins prior to proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p; human ortholog NGLY1 is associated with a syndrome characterized by developmental delays, epilepsy, absence of tears and liver disease","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006017","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL096W"}


id: YPL097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04473":null,"YPL097W":null},"has_protein_features":false,"name":"MSY1","ortholog_annotations":[{"gene_uniquename":"YPL097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04473","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial tyrosyl-tRNA synthetase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006018","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL097W"}


id: YPL098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01120":null,"YPL098C":null},"has_protein_features":false,"name":"MGR2","ortholog_annotations":[{"gene_uniquename":"YPL098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01120","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; provides quality control for insertion of membrane proteins by regulating their release into the inner membrane by the TIM23 complex; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006019","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL098C"}


id: YPL099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_07008":null,"YPL099C":null},"has_protein_features":false,"name":"INA17","ortholog_annotations":[{"gene_uniquename":"YPL099C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07008","reference_uniquename":"PMID:29761456"}],"product":"F1F0 ATPase synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex (Ina22p-Ina17p) involved in assembly of the F1F0 peripheral stalk; co-purifies with Ina22p and ATP synthase subunits; null mutant displays elevated frequency of mitochondrial genome loss and has a respiratory growth defect","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006020","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL099C"}


id: YPL100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATG21","product":"Phosphoinositide binding protein; required for vesicle formation in the cytoplasm-to-vacuole targeting (CVT) pathway, autophagy, micronucleophagy and mitophagy; binds to several phosphoinositides including: PtdIns(3,5)P2, PI3P and PI4P; involved in PI3P-dependent recruitment and organization of both the Atg12-Atg5-Atg16 complex and Atg8p at the pre-autophagosomal structure; necessary for oxidant-induced cell death; WD-40 repeat containing PROPPIN family member","secondary_identifier":"SGD:S000006021","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL100W"}


id: YPL101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03677":null,"YPL101W":null},"has_protein_features":false,"name":"ELP4","ortholog_annotations":[{"gene_uniquename":"YPL101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03677","reference_uniquename":"PMID:29761456"}],"product":"Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; null mutation is functionally complemented by human ELP4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006022","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL101W"}


id: YPL102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4","secondary_identifier":"SGD:S000006023","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL102C"}


id: YPL103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FMP30","product":"Protein with a role in maintaining mitochondrial morphology; also involved in maintaining normal cardiolipin levels; mitochondrial inner membrane protein; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D","secondary_identifier":"SGD:S000006024","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL103C"}


id: YPL104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04094":null,"YPL104W":null},"has_protein_features":false,"name":"MSD1","ortholog_annotations":[{"gene_uniquename":"YPL104W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04094","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial aspartyl-tRNA synthetase; required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006025","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL104W"}


id: YPL105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01279":null,"YPL105C":null},"has_protein_features":false,"name":"SYH1","ortholog_annotations":[{"gene_uniquename":"YPL105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01279","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006026","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL105C"}


id: YPL106C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04511":null,"YPL106C":null},"has_protein_features":false,"name":"SSE1","ortholog_annotations":[{"gene_uniquename":"YPL106C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04511","reference_uniquename":"PMID:29761456"}],"product":"ATPase component of heat shock protein Hsp90 chaperone complex; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; plays a role in prion propagation and determining prion variants; binds unfolded proteins; member of Hsp110 subclass of HSP70 proteins; deletion results in spindle elongation in S phase; SSE1 has a paralog, SSE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006027","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL106C"}


id: YPL107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02559":null,"YPL107W":null},"has_protein_features":false,"name":"DPC25","ortholog_annotations":[{"gene_uniquename":"YPL107W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02559","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; DPC25 is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006028","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL107W"}


id: YPL108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000006029","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL108W"}


id: YPL109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00496":null,"YPL109C":null},"has_protein_features":false,"name":"CQD1","ortholog_annotations":[{"gene_uniquename":"YPL109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00496","reference_uniquename":"PMID:29761456"}],"product":"UbiB family mitochondrial protein; involved in mobilization of CoQ from its site of synthesis on the inner mitochondrial membrane to other sites of action; contains transmembrane domain and mitochondrial targeting sequence","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006030","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL109C"}


id: YPL110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00622":null,"YPL110C":null},"has_protein_features":false,"name":"GDE1","ortholog_annotations":[{"gene_uniquename":"YPL110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00622","reference_uniquename":"PMID:29761456"}],"product":"Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006031","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL110C"}


id: YPL111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03398":null,"YPL111W":null},"has_protein_features":false,"name":"CAR1","ortholog_annotations":[{"gene_uniquename":"YPL111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03398","reference_uniquename":"PMID:29761456"}],"product":"Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006032","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL111W"}


id: YPL112C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEX25","product":"Peripheral peroxisomal membrane peroxin; required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with Pex27p; PEX25 has a paralog, PEX27, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006033","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL112C"}


id: YPL113C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene","secondary_identifier":"SGD:S000006034","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL113C"}


id: YPL114W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index","secondary_identifier":"SGD:S000006035","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL114W"}


id: YPL115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02278":null,"YPL115C":null},"has_protein_features":false,"name":"BEM3","ortholog_annotations":[{"gene_uniquename":"YPL115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02278","reference_uniquename":"PMID:29761456"}],"product":"Rho GTPase activating protein (RhoGAP); involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006036","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL115C"}


id: YPL116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HOS3","product":"Trichostatin A-insensitive homodimeric histone deacetylase (HDAC); specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats","secondary_identifier":"SGD:S000006037","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL116W"}


id: YPL117C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04307":null,"YPL117C":null},"has_protein_features":false,"name":"IDI1","ortholog_annotations":[{"gene_uniquename":"YPL117C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04307","reference_uniquename":"PMID:29761456"}],"product":"Isopentenyl diphosphate:dimethylallyl diphosphate isomerase; catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability; isopentenyl diphosphate:dimethylallyl diphosphate isomerase is also known as IPP isomerase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006038","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL117C"}


id: YPL118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00105":null,"SJAG_02201":null,"YPL118W":null},"has_protein_features":false,"name":"MRP51","ortholog_annotations":[{"gene_uniquename":"YPL118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00105","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02201","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006039","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL118W"}


id: YPL119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00786":null,"YPL119C":null},"has_protein_features":false,"name":"DBP1","ortholog_annotations":[{"gene_uniquename":"YPL119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00786","reference_uniquename":"PMID:29761456"}],"product":"ATP-dependent RNA helicase of the DEAD-box protein family; accelerates eIF4F-dependent assembly of 48S translation preinitiation complex (PIC), stimulating recruitment of mRNAs with long, structured 5'-UTRs; cooperates with DEAD-box RNA helicase and paralog Ded1p, stimulating PIC attachment and highly processive scanning by the 40S ribosomal subunit; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006040","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL119C"}


id: YPL119C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028859","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL119C-A"}


id: YPL120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01876":null,"YPL120W":null},"has_protein_features":false,"name":"VPS30","ortholog_annotations":[{"gene_uniquename":"YPL120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01876","reference_uniquename":"PMID:29761456"}],"product":"Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy, Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has novel globular fold essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of higher eukaryote gene Beclin 1; human BECN1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006041","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL120W"}


id: YPL121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01495":null,"SJAG_01708":null,"YPL121C":null},"has_protein_features":false,"name":"MEI5","ortholog_annotations":[{"gene_uniquename":"YPL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01495","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01708","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006042","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL121C"}


id: YPL122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00901":null,"YPL122C":null},"has_protein_features":false,"name":"TFB2","ortholog_annotations":[{"gene_uniquename":"YPL122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00901","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006043","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL122C"}


id: YPL123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RNY1","product":"Vacuolar RNase of the T(2) family; relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; required for tRNA-specific translational pausing during oxidative stress; promotes apoptosis under stress conditions and this function is independent of Rny1p catalytic activity","secondary_identifier":"SGD:S000006044","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL123C"}


id: YPL124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPC29","product":"Inner plaque spindle pole body (SPB) component; links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication","secondary_identifier":"SGD:S000006045","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL124W"}


id: YPL125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01083":null,"YPL125W":null},"has_protein_features":false,"name":"KAP120","ortholog_annotations":[{"gene_uniquename":"YPL125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01083","reference_uniquename":"PMID:29761456"}],"product":"Karyopherin responsible for the nuclear import of Rpf1p; Rpf1p is a ribosome maturation factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006046","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL125W"}


id: YPL126W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01764":null,"YPL126W":null},"has_protein_features":false,"name":"NAN1","ortholog_annotations":[{"gene_uniquename":"YPL126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01764","reference_uniquename":"PMID:29761456"}],"product":"U3 snoRNP protein; component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006047","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL126W"}


id: YPL127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HHO1","product":"Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination","secondary_identifier":"SGD:S000006048","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL127C"}


id: YPL128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02212":null,"YPL128C":null},"has_protein_features":false,"name":"TBF1","ortholog_annotations":[{"gene_uniquename":"YPL128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02212","reference_uniquename":"PMID:29761456"}],"product":"Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006049","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL128C"}


id: YPL129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00735":null,"YPL129W":null},"has_protein_features":false,"name":"TAF14","ortholog_annotations":[{"gene_uniquename":"YPL129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00735","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006050","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL129W"}


id: YPL130W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPO19","product":"Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation; SPO19 has a paralog, YOR214C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006051","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL130W"}


id: YPL131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01568":null,"SJAG_04066":null,"YPL131W":null},"has_protein_features":false,"name":"RPL5","ortholog_annotations":[{"gene_uniquename":"YPL131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01568","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04066","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L5; nascent Rpl5p is bound by specific chaperone Syo1p during translation; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006052","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL131W"}


id: YPL132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03322":null,"YPL132W":null},"has_protein_features":false,"name":"COX11","ortholog_annotations":[{"gene_uniquename":"YPL132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03322","reference_uniquename":"PMID:29761456"}],"product":"Protein required for delivery of copper to Cox1p; mitochondrial inner membrane protein; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006053","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL132W"}


id: YPL133C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RDS2","product":"Transcription factor involved in regulating gluconeogenesis; also involved in the regulation of glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole","secondary_identifier":"SGD:S000006054","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL133C"}


id: YPL134C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00522":null,"YPL134C":null},"has_protein_features":false,"name":"ODC1","ortholog_annotations":[{"gene_uniquename":"YPL134C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00522","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation; ODC1 has a paralog, ODC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006055","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL134C"}


id: YPL135C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028720","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL135C-A"}


id: YPL135W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00532":null,"YPL135W":null},"has_protein_features":false,"name":"ISU1","ortholog_annotations":[{"gene_uniquename":"YPL135W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00532","reference_uniquename":"PMID:29761456"}],"product":"Conserved protein of the mitochondrial matrix; performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); ISU1 has a paralog, ISU2, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006056","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL135W"}


id: YPL136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C","secondary_identifier":"SGD:S000006057","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL136W"}


id: YPL137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GIP3","product":"Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006058","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL137C"}


id: YPL138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01325":null,"YPL138C":null},"has_protein_features":false,"name":"SPP1","ortholog_annotations":[{"gene_uniquename":"YPL138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01325","reference_uniquename":"PMID:29761456"}],"product":"Subunit of COMPASS (Set1C); a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; promotes meiotic DSB formation by interacting with H3K4me3 and Rec107p, a protein required for Spo11p-catalyzed DSB formation located on chromosome axes; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein; relocalizes to cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006059","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL138C"}


id: YPL139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04758":null,"YPL139C":null},"has_protein_features":false,"name":"UME1","ortholog_annotations":[{"gene_uniquename":"YPL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04758","reference_uniquename":"PMID:29761456"}],"product":"Component of both the Rpd3S and Rpd3L histone deacetylase complexes; negative regulator of meiosis; required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p; UME1 has a paralog, WTM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006060","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL139C"}


id: YPL140C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01181":null,"YPL140C":null},"has_protein_features":false,"name":"MKK2","ortholog_annotations":[{"gene_uniquename":"YPL140C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01181","reference_uniquename":"PMID:29761456"}],"product":"MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006061","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL140C"}


id: YPL141C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04507":null,"YPL141C":null},"has_protein_features":false,"name":"FRK1","ortholog_annotations":[{"gene_uniquename":"YPL141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04507","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006062","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL141C"}


id: YPL142C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit","secondary_identifier":"SGD:S000006063","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL142C"}


id: YPL143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00166":null,"SJAG_04414":null,"YPL143W":null},"has_protein_features":false,"name":"RPL33A","ortholog_annotations":[{"gene_uniquename":"YPL143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00166","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04414","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006064","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL143W"}


id: YPL144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04197":null,"YPL144W":null},"has_protein_features":false,"name":"POC4","ortholog_annotations":[{"gene_uniquename":"YPL144W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04197","reference_uniquename":"PMID:29761456"}],"product":"Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006065","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL144W"}


id: YPL145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01590":null,"SJAG_02323":null,"SJAG_02375":null,"SJAG_03718":null,"YPL145C":null},"has_protein_features":false,"name":"KES1","ortholog_annotations":[{"gene_uniquename":"YPL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01590","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02323","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02375","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03718","reference_uniquename":"PMID:29761456"}],"product":"Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger; one of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006066","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL145C"}


id: YPL146C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00323":null,"YPL146C":null},"has_protein_features":false,"name":"NOP53","ortholog_annotations":[{"gene_uniquename":"YPL146C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00323","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p and with the nucleolar proteins Nop17p and Nip7p; null mutant is viable but growth is severely impaired","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006067","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL146C"}


id: YPL147W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PXA1","product":"Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant","secondary_identifier":"SGD:S000006068","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL147W"}


id: YPL148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03180":null,"YPL148C":null},"has_protein_features":false,"name":"PPT2","ortholog_annotations":[{"gene_uniquename":"YPL148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03180","reference_uniquename":"PMID:29761456"}],"product":"Phosphopantetheine:protein transferase (PPTase); activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006069","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL148C"}


id: YPL149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00059":null,"YPL149W":null},"has_protein_features":false,"name":"ATG5","ortholog_annotations":[{"gene_uniquename":"YPL149W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00059","reference_uniquename":"PMID:29761456"}],"product":"Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3 by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; also involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006070","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL149W"}


id: YPL150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02760":null,"YPL150W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPL150W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02760","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006071","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL150W"}


id: YPL151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04694":null,"YPL151C":null},"has_protein_features":false,"name":"PRP46","ortholog_annotations":[{"gene_uniquename":"YPL151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04694","reference_uniquename":"PMID:29761456"}],"product":"Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006072","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL151C"}


id: YPL152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00078":null,"YPL152W":null},"has_protein_features":false,"name":"RRD2","ortholog_annotations":[{"gene_uniquename":"YPL152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00078","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006073","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL152W"}


id: YPL152W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028721","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL152W-A"}


id: YPL153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04287":null,"YPL153C":null},"has_protein_features":false,"name":"RAD53","ortholog_annotations":[{"gene_uniquename":"YPL153C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04287","reference_uniquename":"PMID:29761456"}],"product":"DNA damage response kinase; signal transduction pathway component required for DNA damage and replication checkpoints, promoting cell cycle arrest and DNA repair; role in initiation of DNA replication; inhibits gene gating through NPC protein phosphorylation, to promote fork stability; activates downstream kinase Dun1p; senses mtDNA depletion and mitochondrial ROS; relocalizes to cytosol under hypoxia; contains two FHA domains; human homolog CHEK2 implicated in breast cancer complements the null","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006074","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL153C"}


id: YPL154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEP4","product":"Vacuolar aspartyl protease (proteinase A); required for posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; plays a protective role in acetic acid induced apoptosis; synthesized as a zymogen, self-activates","secondary_identifier":"SGD:S000006075","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL154C"}


id: YPL155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00851":null,"SJAG_01297":null,"SJAG_02336":null,"YPL155C":null},"has_protein_features":false,"name":"KIP2","ortholog_annotations":[{"gene_uniquename":"YPL155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00851","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01297","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02336","reference_uniquename":"PMID:26896847"}],"product":"Kinesin-related motor protein involved in mitotic spindle positioning; stabilizes microtubules by targeting Bik1p to the plus end; functions as a microtubule polymerase and catastrophe inhibitor in vitro; Kip2p levels are controlled during the cell cycle","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006076","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL155C"}


id: YPL156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PRM4","product":"Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift","secondary_identifier":"SGD:S000006077","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL156C"}


id: YPL157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03901":null,"YPL157W":null},"has_protein_features":false,"name":"TGS1","ortholog_annotations":[{"gene_uniquename":"YPL157W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03901","reference_uniquename":"PMID:29761456"}],"product":"Trimethyl guanosine synthase, conserved nucleolar methyl transferase; converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs; interacts with Swm2p, which may confer substrate specificity on Tgs1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006078","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL157W"}


id: YPL158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AIM44","product":"Regulator of Cdc42p and Rho1p; regulates AMR closure through Hof1p; inhibits Cdc42-dependent Cla4 activation at the division site, to prevent budding in the old bud neck; recruits Nis1p and Nba1p to the division site with Nap1 and the Rax1p-Rax2p dependent inheritance of Nis1p and Nba1p to bud scars to prevent division site repolarization; keeps Rho1p at the division site after AMR contraction to control secondary septum formation; relocalizes from bud neck to cytoplasm upon replication stress","secondary_identifier":"SGD:S000006079","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL158C"}


id: YPL159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PET20","product":"Mitochondrial protein; required for respiratory growth under some conditions and for stability of the mitochondrial genome; subunit of a complex containing Mrx6p, Pim1p, and Mam33p that may regulate mtDNA replication","secondary_identifier":"SGD:S000006080","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL159C"}


id: YPL160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02015":null,"YPL160W":null},"has_protein_features":false,"name":"CDC60","ortholog_annotations":[{"gene_uniquename":"YPL160W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02015","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic leucyl tRNA synthetase; ligates leucine to the appropriate tRNA; human homolog LARS can complement yeast temperature-sensitive mutant at restrictive temperature","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006081","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL160W"}


id: YPL161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04653":null,"YPL161C":null},"has_protein_features":false,"name":"BEM4","ortholog_annotations":[{"gene_uniquename":"YPL161C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04653","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006082","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL161C"}


id: YPL162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology","secondary_identifier":"SGD:S000006083","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL162C"}


id: YPL163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SVS1","product":"Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006084","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL163C"}


id: YPL164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MLH3","product":"Protein involved in DNA mismatch repair and meiotic recombination; involved in crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability","secondary_identifier":"SGD:S000006085","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL164C"}


id: YPL165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02659":null,"YPL165C":null},"has_protein_features":false,"name":"SET6","ortholog_annotations":[{"gene_uniquename":"YPL165C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02659","reference_uniquename":"PMID:29761456"}],"product":"SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006086","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL165C"}


id: YPL166W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATG29","product":"Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","secondary_identifier":"SGD:S000006087","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL166W"}


id: YPL167C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00153":null,"YPL167C":null},"has_protein_features":false,"name":"REV3","ortholog_annotations":[{"gene_uniquename":"YPL167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00153","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; may be involved in meiosis; forms a complex with Rev7p, Pol31p and Pol32p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006088","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL167C"}


id: YPL168W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MRX4","product":"Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated","secondary_identifier":"SGD:S000006089","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL168W"}


id: YPL169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00178":null,"YPL169C":null},"has_protein_features":false,"name":"MEX67","ortholog_annotations":[{"gene_uniquename":"YPL169C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00178","reference_uniquename":"PMID:29761456"}],"product":"Poly(A)RNA binding protein involved in nuclear mRNA export; component of the nuclear pore; ortholog of human TAP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006090","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL169C"}


id: YPL170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02982":null,"YPL170W":null},"has_protein_features":false,"name":"DAP1","ortholog_annotations":[{"gene_uniquename":"YPL170W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02982","reference_uniquename":"PMID:29761456"}],"product":"Heme-binding protein; involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006091","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL170W"}


id: YPL171C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OYE3","product":"Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death","secondary_identifier":"SGD:S000006092","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL171C"}


id: YPL172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03173":null,"YPL172C":null},"has_protein_features":false,"name":"COX10","ortholog_annotations":[{"gene_uniquename":"YPL172C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03173","reference_uniquename":"PMID:29761456"}],"product":"Heme A:farnesyltransferase; catalyzes first step in conversion of protoheme to heme A prosthetic group required for cytochrome c oxidase activity; human ortholog COX10 can complement yeast cox10 null mutant; human ortholog COX10 is associated with mitochondrial disorders","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006093","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL172C"}


id: YPL173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04490":null,"YPL173W":null},"has_protein_features":false,"name":"MRPL40","ortholog_annotations":[{"gene_uniquename":"YPL173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04490","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006094","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL173W"}


id: YPL174C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00140":null,"YPL174C":null},"has_protein_features":false,"name":"NIP100","ortholog_annotations":[{"gene_uniquename":"YPL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00140","reference_uniquename":"PMID:29761456"}],"product":"Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006095","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL174C"}


id: YPL175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04881":null,"YPL175W":null},"has_protein_features":false,"name":"SPT14","ortholog_annotations":[{"gene_uniquename":"YPL175W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04881","reference_uniquename":"PMID:29761456"}],"product":"UDP-glycosyltransferase subunit of the GPI-GnT complex; UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006096","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL175W"}


id: YPL176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02117":null,"YPL176C":null},"has_protein_features":false,"name":"TRE1","ortholog_annotations":[{"gene_uniquename":"YPL176C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02117","reference_uniquename":"PMID:29761456"}],"product":"Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitination and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006097","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL176C"}


id: YPL177C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CUP9","product":"Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000006098","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL177C"}


id: YPL178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01064":null,"YPL178W":null},"has_protein_features":false,"name":"CBC2","ortholog_annotations":[{"gene_uniquename":"YPL178W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01064","reference_uniquename":"PMID:29761456"}],"product":"Small subunit of the heterodimeric cap binding complex with Sto1p; interacts with Npl3p, possibly to package mRNA for export from the nucleus; may have a role in telomere maintenance; contains an RNA-binding motif","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006099","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL178W"}


id: YPL179W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04426":null,"YPL179W":null},"has_protein_features":false,"name":"PPQ1","ortholog_annotations":[{"gene_uniquename":"YPL179W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04426","reference_uniquename":"PMID:29761456"}],"product":"Protein phosphatase that regulates the mating response; negatively regulates the MAP kinase signaling cascade during mating; member of the serine/threonine phosphatase PP1 family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006100","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL179W"}


id: YPL180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01703":null,"YPL180W":null},"has_protein_features":false,"name":"TCO89","ortholog_annotations":[{"gene_uniquename":"YPL180W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01703","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p); regulates global H3K56ac; TORC1 complex regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006101","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL180W"}


id: YPL181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03255":null,"YPL181W":null},"has_protein_features":false,"name":"CTI6","ortholog_annotations":[{"gene_uniquename":"YPL181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03255","reference_uniquename":"PMID:29761456"}],"product":"Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006102","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL181W"}


id: YPL182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W","secondary_identifier":"SGD:S000006103","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL182C"}


id: YPL183C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02352":null,"YPL183C":null},"has_protein_features":false,"name":"RTT10","ortholog_annotations":[{"gene_uniquename":"YPL183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02352","reference_uniquename":"PMID:29761456"}],"product":"WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006104","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL183C"}


id: YPL183W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03040":null,"YPL183W-A":null},"has_protein_features":false,"name":"RTC6","ortholog_annotations":[{"gene_uniquename":"YPL183W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03040","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL183W-A"}


id: YPL184C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MRN1","product":"RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation","secondary_identifier":"SGD:S000006105","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL184C"}


id: YPL185W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C","secondary_identifier":"SGD:S000006106","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL185W"}


id: YPL186C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"UIP4","product":"Protein that interacts with Ulp1p; a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope","secondary_identifier":"SGD:S000006107","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL186C"}


id: YPL187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MF(ALPHA)1","product":"Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor; binds copper(II) ions","secondary_identifier":"SGD:S000006108","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL187W"}


id: YPL188W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03946":null,"YPL188W":null},"has_protein_features":false,"name":"POS5","ortholog_annotations":[{"gene_uniquename":"YPL188W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03946","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial NADH kinase; phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006109","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL188W"}


id: YPL189C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COA2","product":"Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p","secondary_identifier":"SGD:S000028527","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL189C-A"}


id: YPL189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04337":null,"YPL189W":null},"has_protein_features":false,"name":"GUP2","ortholog_annotations":[{"gene_uniquename":"YPL189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04337","reference_uniquename":"PMID:29761456"}],"product":"Probable membrane protein; possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; homolog of the mammalian Hedgehog pathway modulator HHAT; GUP2 has a paralog, GUP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006110","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL189W"}


id: YPL190C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03747":null,"YPL190C":null},"has_protein_features":false,"name":"NAB3","ortholog_annotations":[{"gene_uniquename":"YPL190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03747","reference_uniquename":"PMID:29761456"}],"product":"RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing; Nrd1-Nab3 pathway appears to have a role in rapid suppression of some genes when cells are shifted to poor growth conditions, indicating role for Nrd1-Nab3 in regulating cellular response to nutrient availability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006111","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL190C"}


id: YPL191C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01481":null,"YPL191C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPL191C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01481","reference_uniquename":"PMID:29761456"}],"product":"K48-specific deubiquitinating (DUB) enzyme; MINDY family endo-type deubiquitinase that preferentially cleaves long K48-linked polyubiquitin chains between moieties; diploid deletion strain exhibits high budding index; GFP-fusion protein localizes to the cytoplasm endoplasmic reticulum and cell periphery in high-throughput studies; YPL191C has a paralog, YGL082W, that arose from the whole genome duplication; ortholog of human MINDY2/FAM63B","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006112","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL191C"}


id: YPL192C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PRM3","product":"Protein required for nuclear envelope fusion during karyogamy; pheromone-regulated; peripheral protein of the nuclear membrane; interacts with Kar5p at the spindle pole body","secondary_identifier":"SGD:S000006113","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL192C"}


id: YPL193W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05679":null,"YPL193W":null},"has_protein_features":false,"name":"RSA1","ortholog_annotations":[{"gene_uniquename":"YPL193W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05679","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006114","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL193W"}


id: YPL194W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01605":null,"YPL194W":null},"has_protein_features":false,"name":"DDC1","ortholog_annotations":[{"gene_uniquename":"YPL194W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01605","reference_uniquename":"PMID:29761456"}],"product":"DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006115","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL194W"}


id: YPL195W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00108":null,"YPL195W":null},"has_protein_features":false,"name":"APL5","ortholog_annotations":[{"gene_uniquename":"YPL195W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00108","reference_uniquename":"PMID:29761456"}],"product":"Delta adaptin-like subunit of the clathrin associated protein complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; suppressor of loss of casein kinase 1 function; the clathrin associated protein complex is also known as AP-3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006116","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL195W"}


id: YPL196W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02470":null,"YPL196W":null},"has_protein_features":false,"name":"OXR1","ortholog_annotations":[{"gene_uniquename":"YPL196W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02470","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function required for oxidative damage resistance; required for normal levels of resistance to oxidative damage; null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006117","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL196W"}


id: YPL197C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the ribosomal gene RPL7B","secondary_identifier":"SGD:S000006118","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL197C"}


id: YPL198W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01551":null,"SJAG_03425":null,"YPL198W":null},"has_protein_features":false,"name":"RPL7B","ortholog_annotations":[{"gene_uniquename":"YPL198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01551","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03425","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L7B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006119","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL198W"}


id: YPL199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01979":null,"YPL199C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPL199C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01979","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in nonstop mRNA decay; predicted to be palmitoylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006120","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL199C"}


id: YPL200W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CSM4","product":"Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements; functions with meiosis-specific telomere-binding protein Ndj1p; CSM4 has a paralog, MPS2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006121","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL200W"}


id: YPL201C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YIG1","product":"Protein that interacts with glycerol 3-phosphatase; plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol","secondary_identifier":"SGD:S000006122","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL201C"}


id: YPL202C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AFT2","product":"Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006123","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL202C"}


id: YPL203W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04312":null,"YPL203W":null},"has_protein_features":false,"name":"TPK2","ortholog_annotations":[{"gene_uniquename":"YPL203W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04312","reference_uniquename":"PMID:29761456"}],"product":"cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006124","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL203W"}


id: YPL204W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02104":null,"SJAG_04457":null,"YPL204W":null},"has_protein_features":false,"name":"HRR25","ortholog_annotations":[{"gene_uniquename":"YPL204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02104","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04457","reference_uniquename":"PMID:29761456"}],"product":"Conserved casein kinase, monopolin subunit; regulates diverse events including vesicular traffic, DNA repair, CVT pathway, cohesion cleavage, attachment of sister kinetochores at meiosis I, exit from meiosis II, and ribosomal subunit biogenesis; binds the RNAPII CTD; phosphorylates COPII coat subunits; interacts with Sit4p phosphatase; antagonizes calcineurin signaling, reducing nuclear accumulation of Crz1p; phosphorylates Dsn1p; homolog of mammalian CK1delta","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006125","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL204W"}


id: YPL205C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Hypothetical protein; deletion of locus affects telomere length","secondary_identifier":"SGD:S000006126","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL205C"}


id: YPL206C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02161":null,"YPL206C":null},"has_protein_features":false,"name":"PGC1","ortholog_annotations":[{"gene_uniquename":"YPL206C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02161","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylglycerol phospholipase C; regulates phosphatidylglycerol (PG) accumulation via a phospholipase C-type degradation mechanism; PG levels affect mitochondrial function; contains glycerophosphodiester phosphodiesterase motifs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006127","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL206C"}


id: YPL207W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04265":null,"YPL207W":null},"has_protein_features":false,"name":"TYW1","ortholog_annotations":[{"gene_uniquename":"YPL207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04265","reference_uniquename":"PMID:29761456"}],"product":"Iron-sulfur protein required for synthesis of wybutosine modified tRNA; wybutosine is a modified guanosine found at 3'-position adjacent to anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006128","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL207W"}


id: YPL208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02692":null,"SJAG_03228":null,"YPL208W":null},"has_protein_features":false,"name":"RKM1","ortholog_annotations":[{"gene_uniquename":"YPL208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02692","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03228","reference_uniquename":"PMID:29761456"}],"product":"SET-domain lysine-N-methyltransferase; catalyzes the formation of dimethyllysine residues on the large ribosomal subunit proteins L23 (Rpl23Ap and Rpl23Bp) and monomethyllysine residues on L18 (Rps18Ap and Rps18Bp)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006129","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL208W"}


id: YPL209C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01837":null,"YPL209C":null},"has_protein_features":false,"name":"IPL1","ortholog_annotations":[{"gene_uniquename":"YPL209C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01837","reference_uniquename":"PMID:29761456"}],"product":"Aurora kinase of chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in meiosis I, and kinetochore release from SPB clusters at meiotic exit; helps maintain condensed chromosomes during anaphase; required for SPB cohesion and prevention of multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006130","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL209C"}


id: YPL210C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01840":null,"YPL210C":null},"has_protein_features":false,"name":"SRP72","ortholog_annotations":[{"gene_uniquename":"YPL210C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01840","reference_uniquename":"PMID:29761456"}],"product":"Core component of the signal recognition particle (SRP); the SRP is a ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006131","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL210C"}


id: YPL211W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01839":null,"YPL211W":null},"has_protein_features":false,"name":"NIP7","ortholog_annotations":[{"gene_uniquename":"YPL211W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01839","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein required for 60S ribosome subunit biogenesis; constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006132","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL211W"}


id: YPL212C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00088":null,"SJAG_00319":null,"YPL212C":null},"has_protein_features":false,"name":"PUS1","ortholog_annotations":[{"gene_uniquename":"YPL212C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00088","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL212C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00319","reference_uniquename":"PMID:29761456"}],"product":"tRNA:pseudouridine synthase; introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; also acts on U2 snRNA; also pseudouridylates some mRNAs, and pseudouridylation level varies with growth phase; nuclear protein that appears to be involved in tRNA export; PUS1 has a paralog, PUS2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006133","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL212C"}


id: YPL213W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03210":null,"YPL213W":null},"has_protein_features":false,"name":"LEA1","ortholog_annotations":[{"gene_uniquename":"YPL213W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03210","reference_uniquename":"PMID:29761456"}],"product":"Component of U2 snRNP complex; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006134","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL213W"}


id: YPL214C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00381":null,"YPL214C":null},"has_protein_features":false,"name":"THI6","ortholog_annotations":[{"gene_uniquename":"YPL214C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00381","reference_uniquename":"PMID:29761456"}],"product":"Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase; required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006135","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL214C"}


id: YPL215W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01141":null,"YPL215W":null},"has_protein_features":false,"name":"CBP3","ortholog_annotations":[{"gene_uniquename":"YPL215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01141","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006136","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL215W"}


id: YPL216W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; not an essential gene; YPL216W has a paralog, ITC1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006137","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL216W"}


id: YPL217C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03846":null,"YPL217C":null},"has_protein_features":false,"name":"BMS1","ortholog_annotations":[{"gene_uniquename":"YPL217C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03846","reference_uniquename":"PMID:29761456"}],"product":"GTPase required for ribosomal subunit synthesis and rRNA processing; required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006138","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL217C"}


id: YPL218W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00906":null,"YPL218W":null},"has_protein_features":false,"name":"SAR1","ortholog_annotations":[{"gene_uniquename":"YPL218W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00906","reference_uniquename":"PMID:29761456"}],"product":"ARF family GTPase; component of the COPII vesicle coat; required for transport vesicle formation during ER to Golgi protein transport; lowers membrane rigidity aiding vesicle formation; localizes to ER-mitochondrial contact sites where it enhances membrane curvature, thereby reducing contact size via its N-terminal amphipathic helix; regulates mitochondrial fission and fusion dynamics","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006139","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL218W"}


id: YPL219W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PCL8","product":"Cyclin; interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation; PCL8 has a paralog, PCL10, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006140","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL219W"}


id: YPL220W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02531":null,"SJAG_03122":null,"YPL220W":null},"has_protein_features":false,"name":"RPL1A","ortholog_annotations":[{"gene_uniquename":"YPL220W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02531","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL220W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03122","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal; ribosomes containing Rpl1b are more efficient in translation of respiration-related proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006141","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL220W"}


id: YPL221W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02727":null,"SJAG_04668":null,"YPL221W":null},"has_protein_features":false,"name":"FLC1","ortholog_annotations":[{"gene_uniquename":"YPL221W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02727","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL221W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04668","reference_uniquename":"PMID:29761456"}],"product":"Flavin adenine dinucleotide transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC1 has a paralog, FLC3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006142","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL221W"}


id: YPL222C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028722","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL222C-A"}


id: YPL222W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FMP40","product":"Mitochondrial AMPylator in the pseudokinase selenoprotein-O family; role in the oxidative stress response, transferring AMP from ATP to protein substrates (AMPylation) involved in redox homeostasis; regulates S-glutathionylation levels; proposed involvement in the environmental stress response","secondary_identifier":"SGD:S000006143","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL222W"}


id: YPL223C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GRE1","product":"Hydrophilin essential in desiccation-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; GRE1 has a paralog, SIP18, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006144","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL223C"}


id: YPL224C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04260":null,"YPL224C":null},"has_protein_features":false,"name":"MMT2","ortholog_annotations":[{"gene_uniquename":"YPL224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04260","reference_uniquename":"PMID:29761456"}],"product":"Putative metal transporter involved in mitochondrial iron accumulation; MMT2 has a paralog, MMT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006145","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL224C"}


id: YPL225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02030":null,"YPL225W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPL225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02030","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006146","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL225W"}


id: YPL226W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02704":null,"YPL226W":null},"has_protein_features":false,"name":"NEW1","ortholog_annotations":[{"gene_uniquename":"YPL226W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02704","reference_uniquename":"PMID:29761456"}],"product":"Translation termination and ribosome biogenesis factor; ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006147","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL226W"}


id: YPL227C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00394":null,"YPL227C":null},"has_protein_features":false,"name":"ALG5","ortholog_annotations":[{"gene_uniquename":"YPL227C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00394","reference_uniquename":"PMID:29761456"}],"product":"UDP-glucose:dolichyl-phosphate glucosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum; human ortholog ALG5 can partially complement yeast alg5 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006148","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL227C"}


id: YPL228W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04488":null,"YPL228W":null},"has_protein_features":false,"name":"CET1","ortholog_annotations":[{"gene_uniquename":"YPL228W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04488","reference_uniquename":"PMID:29761456"}],"product":"RNA 5'-triphosphatase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of a Cet1p homodimer and two molecules of guanylyltransferase Ceg1p; Cet1p also has a role in regulation of RNAPII pausing at promoter-proximal sites; interaction between Cet1p and Ceg1p is required for Ceg1p nuclear import; mammalian enzyme is single bifunctional polypeptide; human homolog RNGTT can complement yeast cet1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006149","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL228W"}


id: YPL229W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006150","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL229W"}


id: YPL230W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"USV1","product":"Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006151","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL230W"}


id: YPL231W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04972":null,"YPL231W":null},"has_protein_features":false,"name":"FAS2","ortholog_annotations":[{"gene_uniquename":"YPL231W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04972","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006152","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL231W"}


id: YPL232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03536":null,"YPL232W":null},"has_protein_features":false,"name":"SSO1","ortholog_annotations":[{"gene_uniquename":"YPL232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03536","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p; SSO1 has a paralog, SSO2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006153","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL232W"}


id: YPL233W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01228":null,"YPL233W":null},"has_protein_features":false,"name":"NSL1","ortholog_annotations":[{"gene_uniquename":"YPL233W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01228","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p (MIND)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006154","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL233W"}


id: YPL234C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03406":null,"YPL234C":null},"has_protein_features":false,"name":"VMA11","ortholog_annotations":[{"gene_uniquename":"YPL234C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03406","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar ATPase V0 domain subunit c'; involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006155","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL234C"}


id: YPL235W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03036":null,"YPL235W":null},"has_protein_features":false,"name":"RVB2","ortholog_annotations":[{"gene_uniquename":"YPL235W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03036","reference_uniquename":"PMID:29761456"}],"product":"ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006156","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL235W"}


id: YPL236C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03386":null,"YPL236C":null},"has_protein_features":false,"name":"ENV7","ortholog_annotations":[{"gene_uniquename":"YPL236C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03386","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006157","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL236C"}


id: YPL237W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05003":null,"YPL237W":null},"has_protein_features":false,"name":"SUI3","ortholog_annotations":[{"gene_uniquename":"YPL237W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05003","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of the translation initiation factor eIF2; involved in the identification of the start codon; proposed to be involved in mRNA binding","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006158","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL237W"}


id: YPL238C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W","secondary_identifier":"SGD:S000006159","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL238C"}


id: YPL239W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04611":null,"YPL239W":null},"has_protein_features":false,"name":"YAR1","ortholog_annotations":[{"gene_uniquename":"YPL239W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04611","reference_uniquename":"PMID:29761456"}],"product":"Nucleocytoplasmic shuttling assembly chaperone; co-translationally associates with nascent Rps3p in the cytoplasm and delivers it to pre-ribosomal subunits in the nucleus; required for 40S ribosomal subunit nuclear export, biogenesis and adaptation to osmotic and oxidative stress;  contains ankyrin-repeats; expression repressed by heat shock","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006160","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL239W"}


id: YPL240C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01664":null,"YPL240C":null},"has_protein_features":false,"name":"HSP82","ortholog_annotations":[{"gene_uniquename":"YPL240C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01664","reference_uniquename":"PMID:29761456"}],"product":"Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; promotes solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication; human homolog, HSP90AB1, complements null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006161","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL240C"}


id: YPL241C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01526":null,"YPL241C":null},"has_protein_features":false,"name":"CIN2","ortholog_annotations":[{"gene_uniquename":"YPL241C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01526","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; human homolog RP2 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006162","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL241C"}


id: YPL242C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02379":null,"SJAG_04080":null,"SJAG_04498":null,"YPL242C":null},"has_protein_features":false,"name":"IQG1","ortholog_annotations":[{"gene_uniquename":"YPL242C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02379","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YPL242C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04080","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL242C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04498","reference_uniquename":"PMID:29761456"}],"product":"Actin filament binding protein that enhances actin ring formation; IQGAP family member required for assembly and contraction of the AMR, prior to cytokinesis; localizes to the contractile ring during anaphase in an Mlc1p-dependent manner, recruiting Myo1p and Hof1p to the site, and promoting cytokinetic core complex assembly; specifies bud-site selection, localizing axial markers Bud4p and Cdc12p; regulated by Cdc28p; relocalizes from the bud neck to the cytoplasm upon replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000006163","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL242C"}


id: YPL243W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01759":null,"YPL243W":null},"has_protein_features":false,"name":"SRP68","ortholog_annotations":[{"gene_uniquename":"YPL243W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01759","reference_uniquename":"PMID:29761456"}],"product":"Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006164","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL243W"}


id: YPL244C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04162":null,"YPL244C":null},"has_protein_features":false,"name":"HUT1","ortholog_annotations":[{"gene_uniquename":"YPL244C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04162","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in UDP-galactose transport to the Golgi lumen; has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006165","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL244C"}


id: YPL245W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm","secondary_identifier":"SGD:S000006166","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL245W"}


id: YPL246C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01285":null,"SJAG_05286":null,"YPL246C":null},"has_protein_features":false,"name":"RBD2","ortholog_annotations":[{"gene_uniquename":"YPL246C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01285","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL246C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05286","reference_uniquename":"PMID:29761456"}],"product":"Possible rhomboid protease; has similarity to eukaryotic rhomboid proteases including Pcp1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006167","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL246C"}


id: YPL247C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04087":null,"YPL247C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPL247C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04087","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006168","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL247C"}


id: YPL248C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GAL4","product":"DNA-binding transcription factor required for activating GAL genes; responds to galactose; repressed by Gal80p and activated by Gal3p","secondary_identifier":"SGD:S000006169","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL248C"}


id: YPL249C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00092":null,"SJAG_02012":null,"YPL249C":null},"has_protein_features":false,"name":"GYP5","ortholog_annotations":[{"gene_uniquename":"YPL249C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00092","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL249C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02012","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog, GYL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006170","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL249C"}


id: YPL249C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02121":null,"SJAG_03133":null,"YPL249C-A":null},"has_protein_features":false,"name":"RPL36B","ortholog_annotations":[{"gene_uniquename":"YPL249C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02121","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL249C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03133","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL249C-A"}


id: YPL250C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATG41","product":"Protein of unknown function; required for selective and nonselective autophagy, and mitophagy; regulates the rate of autophagosome formation; interacts with Atg9p, and has a similar peri-mitochondrial localization; elevated Gcn4p-dependent expression under autophagy-inducing conditions; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate; ATG41 has a paralog, ICY1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006171","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL250C"}


id: YPL250W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified ORF RPL36B/YPL249C-A; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028589","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL250W-A"}


id: YPL251W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C","secondary_identifier":"SGD:S000006172","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL251W"}


id: YPL252C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04397":null,"YPL252C":null},"has_protein_features":false,"name":"YAH1","ortholog_annotations":[{"gene_uniquename":"YPL252C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04397","reference_uniquename":"PMID:29761456"}],"product":"Ferredoxin of the mitochondrial matrix; required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; human homolog FDX1L can complement yeast by allowing growth during down-regulation of yeast YAH1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006173","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL252C"}


id: YPL253C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"VIK1","product":"Protein that forms a kinesin-14 heterodimeric motor with Kar3p; localizes Kar3p at mitotic spindle poles; has a structure similar to a kinesin motor domain but lacks an ATP-binding site and is catalytically inactive; binds microtubules; required for sister chromatid cohesion; VIK1 has a paralog, CIK1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006174","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL253C"}


id: YPL254W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03776":null,"YPL254W":null},"has_protein_features":false,"name":"HFI1","ortholog_annotations":[{"gene_uniquename":"YPL254W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03776","reference_uniquename":"PMID:29761456"}],"product":"Adaptor protein required for structural integrity of the SAGA complex; a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006175","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL254W"}


id: YPL255W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BBP1","product":"Protein required for the spindle pole body (SPB) duplication; localizes at the cytoplasmic side of the central plaque periphery of the SPB; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p","secondary_identifier":"SGD:S000006176","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL255W"}


id: YPL256C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CLN2","product":"G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN2 has a paralog, CLN1, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1","secondary_identifier":"SGD:S000006177","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL256C"}


id: YPL257W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene","secondary_identifier":"SGD:S000006178","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL257W"}


id: YPL258C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02420":null,"SJAG_02421":null,"SJAG_04282":null,"YPL258C":null},"has_protein_features":false,"name":"THI21","ortholog_annotations":[{"gene_uniquename":"YPL258C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02420","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL258C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02421","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL258C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04282","reference_uniquename":"PMID:29761456"}],"product":"Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006179","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL258C"}


id: YPL259C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04609":null,"YPL259C":null},"has_protein_features":false,"name":"APM1","ortholog_annotations":[{"gene_uniquename":"YPL259C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04609","reference_uniquename":"PMID:29761456"}],"product":"Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006180","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL259C"}


id: YPL260W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00049":null,"YPL260W":null},"has_protein_features":false,"name":"CUB1","ortholog_annotations":[{"gene_uniquename":"YPL260W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00049","reference_uniquename":"PMID:29761456"}],"product":"Conserved fungal gene linked to DNA repair and proteasome function; putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006181","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL260W"}


id: YPL261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YPL261C is not an essential gene; partially overlaps verified ORF YPL260W","secondary_identifier":"SGD:S000006182","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL261C"}


id: YPL262W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04843":null,"YPL262W":null},"has_protein_features":false,"name":"FUM1","ortholog_annotations":[{"gene_uniquename":"YPL262W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04843","reference_uniquename":"PMID:29761456"}],"product":"Fumarase; converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006183","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL262W"}


id: YPL263C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"KEL3","product":"Cytoplasmic protein of unknown function","secondary_identifier":"SGD:S000006184","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL263C"}


id: YPL264C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01177":null,"SJAG_04697":null,"YPL264C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPL264C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01177","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL264C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04697","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006185","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL264C"}


id: YPL265W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02955":null,"YPL265W":null},"has_protein_features":false,"name":"DIP5","ortholog_annotations":[{"gene_uniquename":"YPL265W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02955","reference_uniquename":"PMID:29761456"}],"product":"Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006186","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL265W"}


id: YPL266W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02821":null,"YPL266W":null},"has_protein_features":false,"name":"DIM1","ortholog_annotations":[{"gene_uniquename":"YPL266W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02821","reference_uniquename":"PMID:29761456"}],"product":"Essential 18S rRNA dimethylase (dimethyladenosine transferase); responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing; human homolog DIMT1 complements yeast dim1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006187","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL266W"}


id: YPL267W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ACM1","product":"Pseudosubstrate inhibitor of the APC/C; suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein; the anaphase-promoting complex/cyclosome is also known as APC/C","secondary_identifier":"SGD:S000006188","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL267W"}


id: YPL268W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00321":null,"YPL268W":null},"has_protein_features":false,"name":"PLC1","ortholog_annotations":[{"gene_uniquename":"YPL268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00321","reference_uniquename":"PMID:29761456"}],"product":"Phospholipase C; hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes; Plc1p and inositol polyphosphates are required for acetyl-CoA homeostasis which regulates global histone acetylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006189","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL268W"}


id: YPL269W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"KAR9","product":"Spindle positioning factor; orients astral microtubules, connecting them to actin cables at the cortex with Bim1p and Myo2, resulting in proper spindle positioning; targeted for StuBL-dependent degradation at kinetochores by Slx5p-Slx8p, ensuring chromosome transmission fidelity and correct spindle positioning; role in karyogamy; localizes to the shmoo tip, the growing bud-tip, the nucleus, the kinetochore, the spindle and microtubules; homolog of adenomatous polyposis coli","secondary_identifier":"SGD:S000006190","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL269W"}


id: YPL270W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MDL2","product":"Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response to H2O2; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis","secondary_identifier":"SGD:S000006191","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL270W"}


id: YPL271W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00915":null,"YPL271W":null},"has_protein_features":false,"name":"ATP15","ortholog_annotations":[{"gene_uniquename":"YPL271W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00915","reference_uniquename":"PMID:29761456"}],"product":"Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006192","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL271W"}


id: YPL272C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PBI1","product":"Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene","secondary_identifier":"SGD:S000006193","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL272C"}


id: YPL273W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04425":null,"YPL273W":null},"has_protein_features":false,"name":"SAM4","ortholog_annotations":[{"gene_uniquename":"YPL273W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04425","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine-homocysteine methyltransferase; functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio; SAM4 has a paralog, YMR321C, that arose from a single-locus duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006194","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL273W"}


id: YPL274W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SAM3","product":"High-affinity S-adenosylmethionine permease; required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p","secondary_identifier":"SGD:S000006195","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL274W"}


id: YPL277C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels","secondary_identifier":"SGD:S000006198","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL277C"}


id: YPL278C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; gene expression regulated by copper levels","secondary_identifier":"SGD:S000006199","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL278C"}


id: YPL279C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01973":null,"YPL279C":null},"has_protein_features":false,"name":"FEX2","ortholog_annotations":[{"gene_uniquename":"YPL279C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01973","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in fluoride export; nearly identical to FEX1, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX domains connected by a linker; part of a widespread family of conserved fluoride export proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006200","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL279C"}


id: YPL280W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02988":null,"SJAG_04674":null,"YPL280W":null},"has_protein_features":false,"name":"HSP32","ortholog_annotations":[{"gene_uniquename":"YPL280W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02988","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL280W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04674","reference_uniquename":"PMID:29761456"}],"product":"Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006201","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL280W"}


id: YPL281C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00461":null,"SJAG_02107":null,"SJAG_02369":null,"YPL281C":null},"has_protein_features":false,"name":"ERR2","ortholog_annotations":[{"gene_uniquename":"YPL281C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00461","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL281C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02107","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPL281C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02369","reference_uniquename":"PMID:29761456"}],"product":"Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006202","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL281C"}


id: YPL282C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU22","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole; identical to Pau21p; encodes two proteins that are translated from two different start codons","secondary_identifier":"SGD:S000006203","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL282C"}


id: YPL283C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YRF1-7","product":"Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p","secondary_identifier":"SGD:S000006204","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL283C"}


id: YPL283W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028723","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL283W-A"}


id: YPL283W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPL283W-B"}


id: YPR001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CIT3","product":"Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate","secondary_identifier":"SGD:S000006205","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR001W"}


id: YPR002C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the Ty1 long terminal repeat, YPRWdelta12","secondary_identifier":"SGD:S000007254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR002C-A"}


id: YPR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PDH1","product":"Putative 2-methylcitrate dehydratase; mitochondrial protein that participates in respiration; induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate","secondary_identifier":"SGD:S000006206","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR002W"}


id: YPR003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01941":null,"YPR003C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01941","reference_uniquename":"PMID:29761456"}],"product":"Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006207","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR003C"}


id: YPR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AIM45","product":"Putative ortholog of mammalian ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response; ETF-alpha is an electron transfer flavoprotein complex subunit","secondary_identifier":"SGD:S000006208","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR004C"}


id: YPR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HAL1","product":"Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p","secondary_identifier":"SGD:S000006209","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR005C"}


id: YPR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ICL2","product":"2-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol","secondary_identifier":"SGD:S000006210","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR006C"}


id: YPR007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03926":null,"YPR007C":null},"has_protein_features":false,"name":"REC8","ortholog_annotations":[{"gene_uniquename":"YPR007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03926","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific component of the sister chromatid cohesion complex; alpha-kleisin family member that maintains cohesion between homologous chromosomes during meiosis I until chromosome arm-associated Rec8p is cleaved by Esp1p; cohesion between sister chromatid centromeres is maintained until metaphase of meiosis II when it is cleaved by Esp1; independent of the role in cohesion, Rec8p promotes allelic collisions and prevents nonspecific chromosome interactions; homolog of S. pombe Rec8p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006211","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR007C"}


id: YPR008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00802":null,"SJAG_01694":null,"YPR008W":null},"has_protein_features":false,"name":"HAA1","ortholog_annotations":[{"gene_uniquename":"YPR008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00802","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01694","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006212","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR008W"}


id: YPR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SUT2","product":"Zn2Cys6 family transcription factor; positively regulates sterol uptake under anaerobic conditions with SUT1; represses filamentation-inducing genes during non-starvation conditions; positively regulates mating along with SUT1 by repressing the expression of genes (PRR2, NCE102 and RHO5) which function as mating inhibitors; multicopy suppressor of mutations that cause low activity of the cAMP/PKA pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006213","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR009W"}


id: YPR010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03578":null,"YPR010C":null},"has_protein_features":false,"name":"RPA135","ortholog_annotations":[{"gene_uniquename":"YPR010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03578","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase I second largest subunit A135","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006214","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR010C"}


id: YPR010C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06392":null,"YPR010C-A":null},"has_protein_features":false,"name":"MIN8","ortholog_annotations":[{"gene_uniquename":"YPR010C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06392","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to cytosol; conserved among Saccharomyces sensu stricto species","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000122558","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR010C-A"}


id: YPR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03334":null,"YPR011C":null},"has_protein_features":false,"name":"MRX21","ortholog_annotations":[{"gene_uniquename":"YPR011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03334","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial transporter; major substrates are adenosine 5'-phosphosulfate (APS) and 3'-phospho-adenosine 5'-phosphosulfate (PAPS); member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006215","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR011C"}


id: YPR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene","secondary_identifier":"SGD:S000006216","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR012W"}


id: YPR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CMR3","product":"Putative zinc finger protein; YPR013C is not an essential gene","secondary_identifier":"SGD:S000006217","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR013C"}


id: YPR014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; YPR014C is not an essential gene","secondary_identifier":"SGD:S000006218","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR014C"}


id: YPR015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative zinc finger transcription factor; binds DNA in sequence-specific manner; overexpression causes a cell cycle delay or arrest","secondary_identifier":"SGD:S000006219","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR015C"}


id: YPR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03012":null,"YPR016C":null},"has_protein_features":false,"name":"TIF6","ortholog_annotations":[{"gene_uniquename":"YPR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03012","reference_uniquename":"PMID:29761456"}],"product":"Constituent of 66S pre-ribosomal particles; has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006220","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR016C"}


id: YPR016W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR016W-A"}


id: YPR017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03142":null,"YPR017C":null},"has_protein_features":false,"name":"DSS4","ortholog_annotations":[{"gene_uniquename":"YPR017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03142","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide dissociation stimulator for Sec4p; functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR017C"}


id: YPR018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04272":null,"YPR018W":null},"has_protein_features":false,"name":"RLF2","ortholog_annotations":[{"gene_uniquename":"YPR018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04272","reference_uniquename":"PMID:29761456"}],"product":"Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including histone H3/H4 tetramerization, silencing at telomeres, mating type loci and rDNA, maintenance of kinetochore structure, deactivation of  DNA damage checkpoint after DNA repair, chromatin dynamics during transcription, and repression of divergent noncoding transcription","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006222","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR018W"}


id: YPR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04210":null,"YPR019W":null},"has_protein_features":false,"name":"MCM4","ortholog_annotations":[{"gene_uniquename":"YPR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04210","reference_uniquename":"PMID:29761456"}],"product":"Essential helicase component of heterohexameric MCM2-7 complexes; MCM2-7 complexes bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR019W"}


id: YPR020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00985":null,"YPR020W":null},"has_protein_features":false,"name":"ATP20","ortholog_annotations":[{"gene_uniquename":"YPR020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00985","reference_uniquename":"PMID:29761456"}],"product":"Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex, which in turn determines oligomerization of the complex and the shape of inner membrane cristae","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR020W"}


id: YPR021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AGC1","product":"Mitochondrial amino acid transporter; acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis; human homolog SLC25A13 complements yeast null mutant","secondary_identifier":"SGD:S000006225","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR021C"}


id: YPR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00163":null,"YPR022C":null},"has_protein_features":false,"name":"SDD4","ortholog_annotations":[{"gene_uniquename":"YPR022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00163","reference_uniquename":"PMID:29761456"}],"product":"Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; overproduction of a truncation allele suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006226","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR022C"}


id: YPR023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00349":null,"YPR023C":null},"has_protein_features":false,"name":"EAF3","ortholog_annotations":[{"gene_uniquename":"YPR023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00349","reference_uniquename":"PMID:29761456"}],"product":"Component of the Rpd3S histone deacetylase complex; Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006227","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR023C"}


id: YPR024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01816":null,"YPR024W":null},"has_protein_features":false,"name":"YME1","ortholog_annotations":[{"gene_uniquename":"YPR024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01816","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of i-AAA protease complex; complex is located in mitochondrial inner membrane; responsible for degradation of unfolded or misfolded mitochondrial gene products; serves as nonconventional translocation motor to pull PNPase into intermembrane space; also has role in intermembrane space protein folding; mutation causes elevated rate of mitochondrial turnover; human homolog YME1L1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006228","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR024W"}


id: YPR025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04614":null,"YPR025C":null},"has_protein_features":false,"name":"CCL1","ortholog_annotations":[{"gene_uniquename":"YPR025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04614","reference_uniquename":"PMID:29761456"}],"product":"Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p; regulates the activity of Kin28p, a TFIIH-associated carboxy-terminal domain (CTD) kinase that facilitates recruitment of mRNA 5'-capping and polyadenylation factors to the RNAPII holoenzyme complex, and has a minor role in RNAPII transcription; subunit of TFIIK, a TFIIH subassembly;  human homolog CCNH allows growth of a yeast ccl1 temperature-sensitive mutant at restrictive temperature","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006229","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR025C"}


id: YPR026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATH1","product":"Acid trehalase required for utilization of extracellular trehalose; involved in intracellular trehalose degradation during growth recovery after saline stress","secondary_identifier":"SGD:S000006230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR026W"}


id: YPR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum, while the mCherry fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000006231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR027C"}


id: YPR028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03795":null,"YPR028W":null},"has_protein_features":false,"name":"YOP1","ortholog_annotations":[{"gene_uniquename":"YPR028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03795","reference_uniquename":"PMID:29761456"}],"product":"Reticulon-interacting protein; ER integral membrane protein involved in the generation of tubular ER morphology; promotes membrane curvature; forms tubules in vitro; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; interacts with Yip1p to mediate membrane traffic and with Sey1p to maintain ER morphology; facilitates lipid exchange between the ER and mitochondria; forms ER foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR028W"}


id: YPR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01809":null,"YPR029C":null},"has_protein_features":false,"name":"APL4","ortholog_annotations":[{"gene_uniquename":"YPR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01809","reference_uniquename":"PMID:29761456"}],"product":"Gamma-adaptin; large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR029C"}


id: YPR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CSR2","product":"Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication","secondary_identifier":"SGD:S000006234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR030W"}


id: YPR031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02629":null,"YPR031W":null},"has_protein_features":false,"name":"NTO1","ortholog_annotations":[{"gene_uniquename":"YPR031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02629","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR031W"}


id: YPR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03754":null,"YPR032W":null},"has_protein_features":false,"name":"SRO7","ortholog_annotations":[{"gene_uniquename":"YPR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03754","reference_uniquename":"PMID:29761456"}],"product":"Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR032W"}


id: YPR033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00103":null,"YPR033C":null},"has_protein_features":false,"name":"HTS1","ortholog_annotations":[{"gene_uniquename":"YPR033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00103","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR033C"}


id: YPR034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03058":null,"YPR034W":null},"has_protein_features":false,"name":"ARP7","ortholog_annotations":[{"gene_uniquename":"YPR034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03058","reference_uniquename":"PMID:26896847"}],"product":"Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000006238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR034W"}


id: YPR035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00359":null,"YPR035W":null},"has_protein_features":false,"name":"GLN1","ortholog_annotations":[{"gene_uniquename":"YPR035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00359","reference_uniquename":"PMID:29761456"}],"product":"Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; forms filaments of back-to-back stacks of cylindrical homo-decamers at low pH, leading to enzymatic inactivation and storage during states of advanced cellular starvation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR035W"}


id: YPR036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04955":null,"YPR036W":null},"has_protein_features":false,"name":"VMA13","ortholog_annotations":[{"gene_uniquename":"YPR036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04955","reference_uniquename":"PMID:29761456"}],"product":"Subunit H of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR036W"}


id: YPR036W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPO24","product":"Small (67 amino acids) protein involved in sporulation; localizes to the prospore membrane; phosphorylated during meiosis; a longer, 5'-extended mRNA is also transcribed beginning in mid-meiosis, regulated by two MSEs (middle sporulation elements), and includes an uORF of 15 codons in its 5'-UTR; evidence transcription is regulated by Pdr1p","secondary_identifier":"SGD:S000028425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR036W-A"}


id: YPR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03992":null,"YPR037C":null},"has_protein_features":false,"name":"ERV2","ortholog_annotations":[{"gene_uniquename":"YPR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03992","reference_uniquename":"PMID:29761456"}],"product":"Flavin-linked sulfhydryl oxidase localized to the ER lumen; involved in disulfide bond formation within the endoplasmic reticulum (ER)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR037C"}


id: YPR038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IRC16","product":"Putative protein of unknown function; partially overlaps verified gene ERV2/YPR037C but doesn't share phenotypes; also overlaps dubious ORF YPR039W; null mutant displays increased levels of spontaneous Rad52p foci, increased biofilm information, different altered sensitivities to various chemcicals","secondary_identifier":"SGD:S000006242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR038W"}


id: YPR039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W","secondary_identifier":"SGD:S000006243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR039W"}


id: YPR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01142":null,"YPR040W":null},"has_protein_features":false,"name":"TIP41","ortholog_annotations":[{"gene_uniquename":"YPR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01142","reference_uniquename":"PMID:29761456"}],"product":"Tap42p-interacting protein; negative regulator of the TORC1 signaling pathway that activates the type 2A-related phosphatase Sit4p by binding and antagonizing Tap42p, a SIT4 inhibitor; proposed to be part of a feedback loop to amplify Sit4p activity when TORC1 is inactivated; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR040W"}


id: YPR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02390":null,"YPR041W":null},"has_protein_features":false,"name":"TIF5","ortholog_annotations":[{"gene_uniquename":"YPR041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02390","reference_uniquename":"PMID:29761456"}],"product":"Translation initiation factor eIF5; functions as both a GTPase-activating protein (GAP) that stimulates the hydrolysis of GTP bound to eIF-2, as part of the 43S preinitiation complex, and as a GDP dissociation inhibitor (GDI) to prevent recycling of eIF2; human ortholog eIF5 complements the yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR041W"}


id: YPR042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00391":null,"SJAG_16457":null,"YPR042C":null},"has_protein_features":false,"name":"PUF2","ortholog_annotations":[{"gene_uniquename":"YPR042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00391","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16457","reference_uniquename":"PMID:29761456"}],"product":"PUF family mRNA-binding protein; Pumilio homology domain confers RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins; binding site composed of two UAAU tetranucleotides, separated by a 3-nt linker; PUF2 has a paralog, JSN1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR042C"}


id: YPR043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02510":null,"SJAG_03043":null,"YPR043W":null},"has_protein_features":false,"name":"RPL43A","ortholog_annotations":[{"gene_uniquename":"YPR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02510","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03043","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR043W"}


id: YPR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OPI11","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; largely overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO","secondary_identifier":"SGD:S000006248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR044C"}


id: YPR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00560":null,"YPR045C":null},"has_protein_features":false,"name":"THP3","ortholog_annotations":[{"gene_uniquename":"YPR045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00560","reference_uniquename":"PMID:29761456"}],"product":"Protein that may have a role in transcription elongation; forms a complex with Csn12p that is recruited to transcribed genes; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR045C"}


id: YPR046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02664":null,"YPR046W":null},"has_protein_features":false,"name":"MCM16","ortholog_annotations":[{"gene_uniquename":"YPR046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02664","reference_uniquename":"PMID:29761456"}],"product":"Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR046W"}


id: YPR047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02615":null,"YPR047W":null},"has_protein_features":false,"name":"MSF1","ortholog_annotations":[{"gene_uniquename":"YPR047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02615","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial phenylalanyl-tRNA synthetase; active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR047W"}


id: YPR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00972":null,"YPR048W":null},"has_protein_features":false,"name":"TAH18","ortholog_annotations":[{"gene_uniquename":"YPR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00972","reference_uniquename":"PMID:29761456"}],"product":"Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance; possible target for development of antifungal drugs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR048W"}


id: YPR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04502":null,"YPR049C":null},"has_protein_features":false,"name":"ATG11","ortholog_annotations":[{"gene_uniquename":"YPR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04502","reference_uniquename":"PMID:29761456"}],"product":"Adapter protein for pexophagy and the Cvt targeting pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the PAS; recruits Dnm1p to facilitate fission of mitochondria that are destined for removal by mitophagy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR049C"}


id: YPR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps verified ORF MAK3/YPR051W","secondary_identifier":"SGD:S000006254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR050C"}


id: YPR051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04131":null,"YPR051W":null},"has_protein_features":false,"name":"MAK3","ortholog_annotations":[{"gene_uniquename":"YPR051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04131","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT); involved in subcellular targeting of select N-terminally acetylated substrates to the Golgi apparatus (Arl3p and Grh1p) and the inner nuclear membrane (Trm1p); required for replication of dsRNA virus; human NatC ortholog, NAA30, functionally complements the null, requiring either auxiliary subunit Mak10p or co-expression of human ortholog, NAA35; NAA60, the human NatF gene, also complements the null allele","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR051W"}


id: YPR052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03603":null,"YPR052C":null},"has_protein_features":false,"name":"NHP6A","ortholog_annotations":[{"gene_uniquename":"YPR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03603","reference_uniquename":"PMID:29761456"}],"product":"High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR052C"}


id: YPR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YPR053C is not an essential gene; partially overlaps verified ORF NHP6A/YPR052C","secondary_identifier":"SGD:S000006257","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR053C"}


id: YPR054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SMK1","product":"Middle sporulation-specific mitogen-activated protein kinase (MAPK); required for prospore membrane development and the production of outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p; activated by Cak1p-mediated phosphorylation of threonine (T207) in the activation loop during meiosis I followed by Ssp2p-promoted autophosphorylation of tyrosine (T209) during meiosis II","secondary_identifier":"SGD:S000006258","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR054W"}


id: YPR055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02320":null,"YPR055W":null},"has_protein_features":false,"name":"SEC8","ortholog_annotations":[{"gene_uniquename":"YPR055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02320","reference_uniquename":"PMID:29761456"}],"product":"Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006259","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR055W"}


id: YPR056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04368":null,"YPR056W":null},"has_protein_features":false,"name":"TFB4","ortholog_annotations":[{"gene_uniquename":"YPR056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04368","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TFIIH complex; involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006260","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR056W"}


id: YPR057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BRR1","product":"snRNP protein component of spliceosomal snRNPs; required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed","secondary_identifier":"SGD:S000006261","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR057W"}


id: YPR058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00626":null,"YPR058W":null},"has_protein_features":false,"name":"YMC1","ortholog_annotations":[{"gene_uniquename":"YPR058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00626","reference_uniquename":"PMID:29761456"}],"product":"Secondary mitochondrial inner membrane glycine transporter; required with HEM25 for the transport of glycine into mitochondria for the initiation of heme biosynthesis; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; localizes to the vacuole in response to H2O2; YMC1 has a paralog, YMC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006262","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR058W"}


id: YPR059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W","secondary_identifier":"SGD:S000006263","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR059C"}


id: YPR060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00518":null,"YPR060C":null},"has_protein_features":false,"name":"ARO7","ortholog_annotations":[{"gene_uniquename":"YPR060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00518","reference_uniquename":"PMID:29761456"}],"product":"Chorismate mutase; catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006264","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR060C"}


id: YPR061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00627":null,"YPR061C":null},"has_protein_features":false,"name":"JID1","ortholog_annotations":[{"gene_uniquename":"YPR061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00627","reference_uniquename":"PMID:29761456"}],"product":"Probable Hsp40p co-chaperone; has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006265","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR061C"}


id: YPR062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FCY1","product":"Cytosine deaminase; zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)","secondary_identifier":"SGD:S000006266","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR062W"}


id: YPR063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05414":null,"YPR063C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YPR063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05414","reference_uniquename":"PMID:29761456"}],"product":"ER-localized protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006267","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR063C"}


id: YPR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YPR064W is not an essential gene","secondary_identifier":"SGD:S000006268","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR064W"}


id: YPR065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ROX1","product":"Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance","secondary_identifier":"SGD:S000006269","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR065W"}


id: YPR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00878":null,"YPR066W":null},"has_protein_features":false,"name":"UBA3","ortholog_annotations":[{"gene_uniquename":"YPR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00878","reference_uniquename":"PMID:29761456"}],"product":"Protein that activates Rub1p (NEDD8) before neddylation; acts together with Ula1p; may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006270","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR066W"}


id: YPR067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04016":null,"YPR067W":null},"has_protein_features":false,"name":"ISA2","ortholog_annotations":[{"gene_uniquename":"YPR067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04016","reference_uniquename":"PMID:29761456"}],"product":"Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006271","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR067W"}


id: YPR068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HOS1","product":"Class I histone deacetylase (HDAC) family member; deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex","secondary_identifier":"SGD:S000006272","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR068C"}


id: YPR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04481":null,"YPR069C":null},"has_protein_features":false,"name":"SPE3","ortholog_annotations":[{"gene_uniquename":"YPR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04481","reference_uniquename":"PMID:29761456"}],"product":"Spermidine synthase; involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006273","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR069C"}


id: YPR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02391":null,"YPR070W":null},"has_protein_features":false,"name":"MED1","ortholog_annotations":[{"gene_uniquename":"YPR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02391","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006274","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR070W"}


id: YPR071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative membrane protein; YPR071W is not an essential gene; YPR071W has a paralog, YIL029C, that arose from a single-locus duplication","secondary_identifier":"SGD:S000006275","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR071W"}


id: YPR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04350":null,"YPR072W":null},"has_protein_features":false,"name":"NOT5","ortholog_annotations":[{"gene_uniquename":"YPR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04350","reference_uniquename":"PMID:29761456"}],"product":"Component of the CCR4-NOT core complex, involved in mRNA decapping; involved intranscription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not5p and Not3p is mutated in cancers","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006276","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR072W"}


id: YPR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01667":null,"YPR073C":null},"has_protein_features":false,"name":"LTP1","ortholog_annotations":[{"gene_uniquename":"YPR073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01667","reference_uniquename":"PMID:29761456"}],"product":"Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006277","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR073C"}


id: YPR074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03934":null,"YPR074C":null},"has_protein_features":false,"name":"TKL1","ortholog_annotations":[{"gene_uniquename":"YPR074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03934","reference_uniquename":"PMID:29761456"}],"product":"Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006278","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR074C"}


id: YPR074W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Hypothetical protein identified by homology","secondary_identifier":"SGD:S000007631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR074W-A"}


id: YPR075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OPY2","product":"Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress","secondary_identifier":"SGD:S000006279","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR075C"}


id: YPR076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000006280","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR076W"}


id: YPR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1","secondary_identifier":"SGD:S000006281","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR077C"}


id: YPR078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible","secondary_identifier":"SGD:S000006282","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR078C"}


id: YPR079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02049":null,"YPR079W":null},"has_protein_features":false,"name":"MRL1","ortholog_annotations":[{"gene_uniquename":"YPR079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02049","reference_uniquename":"PMID:29761456"}],"product":"Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006283","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR079W"}


id: YPR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01851":null,"SJAG_02180":null,"SJAG_04157":null,"YPR080W":null},"has_protein_features":false,"name":"TEF1","ortholog_annotations":[{"gene_uniquename":"YPR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01851","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02180","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YPR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04157","reference_uniquename":"PMID:29761456"}],"product":"Translational elongation factor EF-1 alpha; GTP-bound active form, binds to and delivers aminoacylated tRNA to the A-site of ribosomes for elongation of nascent polypeptides; moonlighting function as an actin binding and bundling protein; association with GTPase Rho1p on the vacuolar membrane may facilitate F-actin remodeling; involved in tRNA re-export from the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006284","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR080W"}


id: YPR081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01352":null,"YPR081C":null},"has_protein_features":false,"name":"GRS2","ortholog_annotations":[{"gene_uniquename":"YPR081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01352","reference_uniquename":"PMID:29761456"}],"product":"Glycine-tRNA synthetase, not expressed under normal growth conditions; expression is induced under heat, oxidative, pH, or ethanol stress conditions; more stable than the major glycine-tRNA synthetase Grs1p at 37 deg C; GRS2 has a paralog, GRS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006285","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR081C"}


id: YPR082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04222":null,"YPR082C":null},"has_protein_features":false,"name":"DIB1","ortholog_annotations":[{"gene_uniquename":"YPR082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04222","reference_uniquename":"PMID:29761456"}],"product":"17-kDa component of the U4/U6aU5 tri-snRNP; plays an essential role in pre-mRNA splicing; human ortholog TXNL4A (the human U5-specific 15-kDa protein) complements yeast dib1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006286","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR082C"}


id: YPR083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MDM36","product":"Mitochondrial protein; required for normal mitochondrial morphology and inheritance; component of the mitochondria-ER-cortex-anchor (MECA); interacts with Num1p to link the ER and mitochondria at the cell cortex; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission","secondary_identifier":"SGD:S000006287","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR083W"}


id: YPR084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000006288","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR084W"}


id: YPR085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04784":null,"YPR085C":null},"has_protein_features":false,"name":"ASA1","ortholog_annotations":[{"gene_uniquename":"YPR085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04784","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006289","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR085C"}


id: YPR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01523":null,"YPR086W":null},"has_protein_features":false,"name":"SUA7","ortholog_annotations":[{"gene_uniquename":"YPR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01523","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006290","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YPR086W"}


