# genes

id: YGL217C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W","secondary_identifier":"SGD:S000003185","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL217C"}


id: YGL218W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance","secondary_identifier":"SGD:S000003186","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL218W"}


id: YGL219C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01305":null,"YGL219C":null},"has_protein_features":false,"name":"MDM34","ortholog_annotations":[{"gene_uniquename":"YGL219C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01305","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial component of the ERMES complex; links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003187","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL219C"}


id: YGL220W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02474":null,"YGL220W":null},"has_protein_features":false,"name":"BOL2","ortholog_annotations":[{"gene_uniquename":"YGL220W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02474","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic protein involved in repression of iron regulon transcription; forms an iron-independent complex with Fra1p, Grx3p, and Grx4p; null mutant fails to repress the iron regulon and is sensitive to nickel; sequence similarity to human BOLA family member, BOLA2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003188","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL220W"}


id: YGL221C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04563":null,"YGL221C":null},"has_protein_features":false,"name":"NIF3","ortholog_annotations":[{"gene_uniquename":"YGL221C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04563","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003189","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL221C"}


id: YGL222C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01746":null,"YGL222C":null},"has_protein_features":false,"name":"EDC1","ortholog_annotations":[{"gene_uniquename":"YGL222C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01746","reference_uniquename":"PMID:29761456"}],"product":"RNA-binding protein that activates mRNA decapping directly; binds to mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; EDC1 has a paralog, EDC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003190","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL222C"}


id: YGL223C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00041":null,"YGL223C":null},"has_protein_features":false,"name":"COG1","ortholog_annotations":[{"gene_uniquename":"YGL223C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00041","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003191","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL223C"}


id: YGL224C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02593":null,"YGL224C":null},"has_protein_features":false,"name":"SDT1","ortholog_annotations":[{"gene_uniquename":"YGL224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02593","reference_uniquename":"PMID:29761456"}],"product":"Pyrimidine nucleotidase; responsible for production of nicotinamide riboside and nicotinic acid riboside; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives; SDT1 has a paralog, PHM8, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003192","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL224C"}


id: YGL225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00339":null,"YGL225W":null},"has_protein_features":false,"name":"VRG4","ortholog_annotations":[{"gene_uniquename":"YGL225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00339","reference_uniquename":"PMID:29761456"}],"product":"Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi; VRG4 has a paralog, HVG1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003193","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL225W"}


id: YGL226C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OST5","product":"Zeta subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins","secondary_identifier":"SGD:S000003194","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL226C-A"}


id: YGL226W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MTC3","product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1","secondary_identifier":"SGD:S000003195","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL226W"}


id: YGL227W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01678":null,"YGL227W":null},"has_protein_features":false,"name":"VID30","ortholog_annotations":[{"gene_uniquename":"YGL227W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01678","reference_uniquename":"PMID:29761456"}],"product":"Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003196","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL227W"}


id: YGL228W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SHE10","product":"Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; putative GPI-anchored protein; overexpression causes growth arrest;; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; SHE10 has a paralog, OSW7/YFR039C, that arose from the whole genome duplication; paralogs are redundant for spore wall dityrosine assembly","secondary_identifier":"SGD:S000003197","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL228W"}


id: YGL229C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04638":null,"YGL229C":null},"has_protein_features":false,"name":"SAP4","ortholog_annotations":[{"gene_uniquename":"YGL229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04638","reference_uniquename":"PMID:29761456"}],"product":"Protein required for function of the Sit4p protein phosphatase; member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p; SAP4 has a paralog, SAP155, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003198","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL229C"}


id: YGL230C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; non-essential gene","secondary_identifier":"SGD:S000003199","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL230C"}


id: YGL231C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02914":null,"YGL231C":null},"has_protein_features":false,"name":"EMC4","ortholog_annotations":[{"gene_uniquename":"YGL231C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02914","reference_uniquename":"PMID:29761456"}],"product":"Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4 and fly CG11137; mutation is functionally complemented by human EMC4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003200","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL231C"}


id: YGL232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01638":null,"YGL232W":null},"has_protein_features":false,"name":"TAN1","ortholog_annotations":[{"gene_uniquename":"YGL232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01638","reference_uniquename":"PMID:29761456"}],"product":"Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003201","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL232W"}


id: YGL233W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03864":null,"YGL233W":null},"has_protein_features":false,"name":"SEC15","ortholog_annotations":[{"gene_uniquename":"YGL233W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03864","reference_uniquename":"PMID:29761456"}],"product":"Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003202","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL233W"}


id: YGL234W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03140":null,"YGL234W":null},"has_protein_features":false,"name":"ADE57","ortholog_annotations":[{"gene_uniquename":"YGL234W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03140","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional enzyme of 'de novo' purine nucleotide pathway; contains both phosphoribosylglycinamidine synthetase/glycinamide ribotide synthetase (EC 6.3.4.13) [\"Ade5\"] and phosphoribosylaminoimidazole synthetase/aminoimidazole ribotide synthetase (EC 6.3.3.1) [\"Ade7\"] activities","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003203","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL234W"}


id: YGL235W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2","secondary_identifier":"SGD:S000003204","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL235W"}


id: YGL236C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04367":null,"YGL236C":null},"has_protein_features":false,"name":"MTO1","ortholog_annotations":[{"gene_uniquename":"YGL236C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04367","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein; forms heterodimer complex with Mss1p that performs 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants; human homolog MTO1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003205","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL236C"}


id: YGL237C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00698":null,"YGL237C":null},"has_protein_features":false,"name":"HAP2","ortholog_annotations":[{"gene_uniquename":"YGL237C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00698","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding; respiratory defect of the null mutant is functionally complemented by human NFYA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003206","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL237C"}


id: YGL238W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04366":null,"YGL238W":null},"has_protein_features":false,"name":"CSE1","ortholog_annotations":[{"gene_uniquename":"YGL238W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04366","reference_uniquename":"PMID:29761456"}],"product":"Nuclear envelope protein that acts as a recycling factor; mediates the nuclear export of Srp1p (importin alpha) back to the cytoplasm after its import substrates have been released into the nucleoplasm, thereby allowing the participation of Srp1p in multiple rounds of nuclear import; required for accurate chromosome segregation; homolog of metazoan CAS and human CSE1L, overexpression of which is implicated in cancer progression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003207","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL238W"}


id: YGL239C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene CSE1","secondary_identifier":"SGD:S000003208","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL239C"}


id: YGL240W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03561":null,"YGL240W":null},"has_protein_features":false,"name":"DOC1","ortholog_annotations":[{"gene_uniquename":"YGL240W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03561","reference_uniquename":"PMID:29761456"}],"product":"Processivity factor; required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003209","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL240W"}


id: YGL241W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01789":null,"YGL241W":null},"has_protein_features":false,"name":"KAP114","ortholog_annotations":[{"gene_uniquename":"YGL241W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01789","reference_uniquename":"PMID:29761456"}],"product":"Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003210","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL241W"}


id: YGL242C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02857":null,"YGL242C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGL242C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02857","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; N-terminally propionylated in vivo; deletion mutant is viable","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003211","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL242C"}


id: YGL243W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04380":null,"YGL243W":null},"has_protein_features":false,"name":"TAD1","ortholog_annotations":[{"gene_uniquename":"YGL243W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04380","reference_uniquename":"PMID:29761456"}],"product":"tRNA-specific adenosine deaminase; deaminates adenosine-37 to inosine in tRNA-Ala","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003212","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL243W"}


id: YGL244W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04933":null,"YGL244W":null},"has_protein_features":false,"name":"RTF1","ortholog_annotations":[{"gene_uniquename":"YGL244W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04933","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003213","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL244W"}


id: YGL245W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03277":null,"YGL245W":null},"has_protein_features":false,"name":"GUS1","ortholog_annotations":[{"gene_uniquename":"YGL245W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03277","reference_uniquename":"PMID:29761456"}],"product":"Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003214","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL245W"}


id: YGL246C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02374":null,"YGL246C":null},"has_protein_features":false,"name":"RAI1","ortholog_annotations":[{"gene_uniquename":"YGL246C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02374","reference_uniquename":"PMID:29761456"}],"product":"Nuclear decapping endonuclease; targets mRNAs with unmethylated 7-methylguanosine cap structures and 5'-triphosphates; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; involved in an early step of decapping nicotinamide adenine dinucleotide (NAD) capped nuclear NAD-RNAs; relocalizes to the cytosol in response to hypoxia; homologous to human DOM3Z","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003215","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL246C"}


id: YGL247W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01422":null,"YGL247W":null},"has_protein_features":false,"name":"BRR6","ortholog_annotations":[{"gene_uniquename":"YGL247W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01422","reference_uniquename":"PMID:29761456"}],"product":"Essential nuclear envelope integral membrane protein; interacts with chromatin, helping to maintain normal chromatin architecture and transcriptional regulation of certain loci at the nuclear envelope; interacts and functions with Apq12p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA nuclear export, and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; homologous to Brl1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003216","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL247W"}


id: YGL248W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02481":null,"YGL248W":null},"has_protein_features":false,"name":"PDE1","ortholog_annotations":[{"gene_uniquename":"YGL248W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02481","reference_uniquename":"PMID:29761456"}],"product":"Low-affinity cyclic AMP phosphodiesterase; controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003217","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL248W"}


id: YGL249W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ZIP2","product":"Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000003218","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL249W"}


id: YGL250W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02483":null,"YGL250W":null},"has_protein_features":false,"name":"RMR1","ortholog_annotations":[{"gene_uniquename":"YGL250W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02483","reference_uniquename":"PMID:29761456"}],"product":"Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003219","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL250W"}


id: YGL251C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HFM1","product":"Meiosis specific DNA helicase; involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity","secondary_identifier":"SGD:S000003220","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL251C"}


id: YGL252C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RTG2","product":"Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p","secondary_identifier":"SGD:S000003221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL252C"}


id: YGL253W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04334":null,"YGL253W":null},"has_protein_features":false,"name":"HXK2","ortholog_annotations":[{"gene_uniquename":"YGL253W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04334","reference_uniquename":"PMID:29761456"}],"product":"Hexokinase isoenzyme 2; phosphorylates glucose in cytosol; predominant hexokinase during growth on glucose; represses expression of HXK1, GLK1, induces expression of its own gene; antiapoptotic; phosphorylation/dephosphorylation at Ser14 by kinase Snf1p, phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; functions downstream of Sit4p in control of cell cycle, mitochondrial function, oxidative stress resistance, chronological lifespan; has paralog HXK1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003222","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL253W"}


id: YGL254W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FZF1","product":"Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL254W"}


id: YGL255W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04185":null,"YGL255W":null},"has_protein_features":false,"name":"ZRT1","ortholog_annotations":[{"gene_uniquename":"YGL255W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04185","reference_uniquename":"PMID:29761456"}],"product":"High-affinity zinc transporter of the plasma membrane; responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL255W"}


id: YGL256W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00240":null,"SJAG_03822":null,"YGL256W":null},"has_protein_features":false,"name":"ADH4","ortholog_annotations":[{"gene_uniquename":"YGL256W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00240","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL256W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03822","reference_uniquename":"PMID:29761456"}],"product":"Alcohol dehydrogenase isoenzyme type IV; dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003225","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL256W"}


id: YGL257C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MNT2","product":"Mannosyltransferase; involved in adding the 4th and 5th mannose residues of O-linked glycans","secondary_identifier":"SGD:S000003226","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL257C"}


id: YGL258W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00161":null,"YGL258W":null},"has_protein_features":false,"name":"VEL1","ortholog_annotations":[{"gene_uniquename":"YGL258W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00161","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has a paralog, YOR387C, that arose from a single-locus duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003227","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL258W"}


id: YGL258W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000007607","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL258W-A"}


id: YGL259W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YPS5","product":"Protein with similarity to GPI-anchored aspartic proteases; such proteases are Yap1p and Yap3p; mCherry fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000003228","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL259W"}


id: YGL260W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium","secondary_identifier":"SGD:S000003229","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL260W"}


id: YGL261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU11","product":"Putative protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2","secondary_identifier":"SGD:S000003230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL261C"}


id: YGL262W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene","secondary_identifier":"SGD:S000003231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL262W"}


id: YGL263W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COS12","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000003232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL263W"}


id: YGR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"EFM5","product":"S-adenosylmethionine-dependent lysine methyltransferase; involved in the trimethylation of eEF1A (Tef1p/Tef2p) at lysine 79; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in budding yeast; expresses a circular RNA; originally misclassified as a N-6-adenine specific DNA methyltransferase based on sequence similarity; both Efm5p and human ortholog N6AMT2 can methylate eEF1a from either species in vitro","secondary_identifier":"SGD:S000003233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR001C"}


id: YGR002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02385":null,"YGR002C":null},"has_protein_features":false,"name":"SWC4","ortholog_annotations":[{"gene_uniquename":"YGR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02385","reference_uniquename":"PMID:29761456"}],"product":"Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR002C"}


id: YGR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04335":null,"YGR003W":null},"has_protein_features":false,"name":"CUL3","ortholog_annotations":[{"gene_uniquename":"YGR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04335","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-protein ligase; forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR003W"}


id: YGR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEX31","product":"Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p; PEX31 has a paralog, PEX30, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR004W"}


id: YGR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04852":null,"YGR005C":null},"has_protein_features":false,"name":"TFG2","ortholog_annotations":[{"gene_uniquename":"YGR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04852","reference_uniquename":"PMID:29761456"}],"product":"TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR005C"}


id: YGR006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02455":null,"YGR006W":null},"has_protein_features":false,"name":"PRP18","ortholog_annotations":[{"gene_uniquename":"YGR006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02455","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor and component of snRNP U5; factor involved in the positioning of the 3' splice site during the second catalytic step of splicing; interacts with Slu7p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR006W"}


id: YGR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04628":null,"YGR007W":null},"has_protein_features":false,"name":"ECT1","ortholog_annotations":[{"gene_uniquename":"YGR007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04628","reference_uniquename":"PMID:29761456"}],"product":"Ethanolamine-phosphate cytidylyltransferase; catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases; inability of the null mutant to synthesize phosphatidylethanolamine and phosphatidylcholine from ethanolamine is functionally complemented by human PCYT2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR007W"}


id: YGR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"STF2","product":"Protein involved in resistance to desiccation stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to F0 sector of mitochondrial F1F0 ATPase in vitro and may modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress; STF2 has a paralog, TMA10, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR008C"}


id: YGR009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00826":null,"YGR009C":null},"has_protein_features":false,"name":"SEC9","ortholog_annotations":[{"gene_uniquename":"YGR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00826","reference_uniquename":"PMID:29761456"}],"product":"t-SNARE protein required for secretory vesicle-plasma membrane fusion; similar to but not functionally redundant with Spo20p; interacts non-exocyst bound Sec6p; SNAP-25 homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR009C"}


id: YGR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02889":null,"YGR010W":null},"has_protein_features":false,"name":"NMA2","ortholog_annotations":[{"gene_uniquename":"YGR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02889","reference_uniquename":"PMID:29761456"}],"product":"Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); homolog of human NMNAT; NMA2 has a paralog, NMA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR010W"}


id: YGR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR011W"}


id: YGR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00582":null,"SJAG_01880":null,"YGR012W":null},"has_protein_features":false,"name":"MCY1","ortholog_annotations":[{"gene_uniquename":"YGR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00582","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01880","reference_uniquename":"PMID:29761456"}],"product":"Putative cysteine synthase; localized to the mitochondrial outer membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR012W"}


id: YGR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04163":null,"YGR013W":null},"has_protein_features":false,"name":"SNU71","ortholog_annotations":[{"gene_uniquename":"YGR013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04163","reference_uniquename":"PMID:29761456"}],"product":"Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR013W"}


id: YGR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MSB2","product":"Mucin family member involved in various signaling pathways; functions as osmosensor in the Sho1p-mediated HOG pathway; functions in Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; processed into secreted and cell-associated forms by aspartyl protease Yps1p; potential Cdc28p substrate","secondary_identifier":"SGD:S000003246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR014W"}


id: YGR015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00734":null,"YGR015C":null},"has_protein_features":false,"name":"EAT1","ortholog_annotations":[{"gene_uniquename":"YGR015C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00734","reference_uniquename":"PMID:29761456"}],"product":"Ethanol acetyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR015C"}


id: YGR016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06268":null,"YGR016W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06268","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR016W"}


id: YGR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00707":null,"YGR017W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00707","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR017W"}


id: YGR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W","secondary_identifier":"SGD:S000003250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR018C"}


id: YGR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03434":null,"YGR019W":null},"has_protein_features":false,"name":"UGA1","ortholog_annotations":[{"gene_uniquename":"YGR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03434","reference_uniquename":"PMID:29761456"}],"product":"Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR019W"}


id: YGR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04015":null,"YGR020C":null},"has_protein_features":false,"name":"VMA7","ortholog_annotations":[{"gene_uniquename":"YGR020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04015","reference_uniquename":"PMID:29761456"}],"product":"Subunit F of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR020C"}


id: YGR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03550":null,"YGR021W":null},"has_protein_features":false,"name":"DPC29","ortholog_annotations":[{"gene_uniquename":"YGR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03550","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR021W"}


id: YGR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W","secondary_identifier":"SGD:S000003254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR022C"}


id: YGR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MTL1","product":"Putative plasma membrane sensor; involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p; MTL1 has a paralog, MID2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR023W"}


id: YGR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04233":null,"YGR024C":null},"has_protein_features":false,"name":"THG1","ortholog_annotations":[{"gene_uniquename":"YGR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04233","reference_uniquename":"PMID:29761456"}],"product":"tRNAHis guanylyltransferase; adds a guanosine residue to the 5' end of tRNAH is after transcription and RNase P cleavage; can also catalyze reverse (3'-5') polymerization with certain substrates in a template-dependent reaction; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR024C"}


id: YGR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000003257","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR025W"}


id: YGR026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01460":null,"YGR026W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01460","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003258","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR026W"}


id: YGR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04672":null,"YGR027C":null},"has_protein_features":false,"name":"RPS25A","ortholog_annotations":[{"gene_uniquename":"YGR027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04672","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003259","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR027C"}


id: YGR028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04203":null,"YGR028W":null},"has_protein_features":false,"name":"MSP1","ortholog_annotations":[{"gene_uniquename":"YGR028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04203","reference_uniquename":"PMID:29761456"}],"product":"Highly-conserved N-terminally anchored AAA-ATPase; distributed in the mitochondrial outer membrane and peroxisomes; involved in mitochondrial protein sorting; functions as an extraction engine in local organelle surveillance to remove and initiate degradation of mistargeted proteins, ensuring fidelity of organelle-specific localization of tail-anchored proteins; contains an N-terminal transmembrane domain and C-terminal cytoplasmic ATPase domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003260","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR028W"}


id: YGR029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01647":null,"YGR029W":null},"has_protein_features":false,"name":"ERV1","ortholog_annotations":[{"gene_uniquename":"YGR029W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01647","reference_uniquename":"PMID:29761456"}],"product":"Flavin-linked sulfhydryl oxidase of the mitochondrial IMS; N-terminus is an intrinsically disordered domain that in the cytosol helps target Erv1p to mitochondria, and in the intermembrane space oxidizes Mia40p as part of a disulfide relay system that promotes intermembrane space retention of imported proteins; functional ortholog of human GFER (ALR); human GFER carrying N-terminal 21 amino acids of Erv1p functionally complements the lethality of the erv1 null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003261","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR029W"}


id: YGR030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01369":null,"SJAG_06613":null,"YGR030C":null},"has_protein_features":false,"name":"POP6","ortholog_annotations":[{"gene_uniquename":"YGR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01369","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06613","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop7p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003262","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR030C"}


id: YGR031C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NAG1","product":"Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; gene is nested within and antisense to IMO32","secondary_identifier":"SGD:S000028636","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR031C-A"}


id: YGR031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00734":null,"YGR031W":null},"has_protein_features":false,"name":"IMO32","ortholog_annotations":[{"gene_uniquename":"YGR031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00734","reference_uniquename":"PMID:29761456"}],"product":"Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003263","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR031W"}


id: YGR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01288":null,"SJAG_02222":null,"SJAG_03587":null,"SJAG_05285":null,"YGR032W":null},"has_protein_features":false,"name":"GSC2","ortholog_annotations":[{"gene_uniquename":"YGR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01288","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02222","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03587","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05285","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of 1,3-beta-glucan synthase; involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; GSC2 has a paralog, FKS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003264","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR032W"}


id: YGR033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01442":null,"YGR033C":null},"has_protein_features":false,"name":"TIM21","ortholog_annotations":[{"gene_uniquename":"YGR033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01442","reference_uniquename":"PMID:29761456"}],"product":"Nonessential component of the TIM23 complex; interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate the Translocase of the Inner Mitochondrial membrane (TIM23 complex) activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003265","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR033C"}


id: YGR034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00921":null,"YGR034W":null},"has_protein_features":false,"name":"RPL26B","ortholog_annotations":[{"gene_uniquename":"YGR034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00921","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003266","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR034W"}


id: YGR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YGR035C has a paralog, YLR346C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003267","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR035C"}


id: YGR035W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028827","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR035W-A"}


id: YGR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02056":null,"YGR036C":null},"has_protein_features":false,"name":"CAX4","ortholog_annotations":[{"gene_uniquename":"YGR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02056","reference_uniquename":"PMID:29761456"}],"product":"Dolichyl pyrophosphate (Dol-P-P) phosphatase; cleaves the anhydride linkage in Dol-P-P; involved in  synthesis of Dol-P-P-linked oligosaccharide intermediate required for protein N-glycosylation; has a luminally oriented active site in the ER; mutation affects vesicular transport, membrane and cell wall biogenesis and lipid homeostasis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003268","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR036C"}


id: YGR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01458":null,"YGR037C":null},"has_protein_features":false,"name":"ACB1","ortholog_annotations":[{"gene_uniquename":"YGR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01458","reference_uniquename":"PMID:29761456"}],"product":"Acyl-CoA-binding protein; transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003269","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR037C"}


id: YGR038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04550":null,"YGR038W":null},"has_protein_features":false,"name":"ORM1","ortholog_annotations":[{"gene_uniquename":"YGR038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04550","reference_uniquename":"PMID:29761456"}],"product":"Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; ORM1 has a paralog, ORM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003270","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR038W"}


id: YGR039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YGR039W is not an essential gene","secondary_identifier":"SGD:S000003271","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR039W"}


id: YGR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02923":null,"YGR040W":null},"has_protein_features":false,"name":"KSS1","ortholog_annotations":[{"gene_uniquename":"YGR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02923","reference_uniquename":"PMID:29761456"}],"product":"Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate Bni4p; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003272","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR040W"}


id: YGR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BUD9","product":"Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole; BUD9 has a paralog, BUD8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003273","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR041W"}


id: YGR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02616":null,"YGR042W":null},"has_protein_features":false,"name":"MTE1","ortholog_annotations":[{"gene_uniquename":"YGR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02616","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003274","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR042W"}


id: YGR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04263":null,"YGR043C":null},"has_protein_features":false,"name":"NQM1","ortholog_annotations":[{"gene_uniquename":"YGR043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04263","reference_uniquename":"PMID:29761456"}],"product":"Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; NQM1 has a paralog, TAL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003275","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR043C"}


id: YGR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RME1","product":"Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000003276","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR044C"}


id: YGR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000003277","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR045C"}


id: YGR046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03563":null,"YGR046W":null},"has_protein_features":false,"name":"TAM41","ortholog_annotations":[{"gene_uniquename":"YGR046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03563","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase); required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003278","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR046W"}


id: YGR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01827":null,"YGR047C":null},"has_protein_features":false,"name":"TFC4","ortholog_annotations":[{"gene_uniquename":"YGR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01827","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003279","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR047C"}


id: YGR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04384":null,"YGR048W":null},"has_protein_features":false,"name":"UFD1","ortholog_annotations":[{"gene_uniquename":"YGR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04384","reference_uniquename":"PMID:29761456"}],"product":"Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transcription factors by regulated Ub/proteasome-dependent processing (RUP)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003280","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR048W"}


id: YGR049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SCM4","product":"Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation; SCM4 has a paralog, ATG33, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003281","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR049W"}


id: YGR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data","secondary_identifier":"SGD:S000003282","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR050C"}


id: YGR051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene","secondary_identifier":"SGD:S000003283","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR051C"}


id: YGR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03529":null,"YGR052W":null},"has_protein_features":false,"name":"FMP48","ortholog_annotations":[{"gene_uniquename":"YGR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03529","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000003284","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR052W"}


id: YGR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06256":null,"YGR053C":null},"has_protein_features":false,"name":"MCO32","ortholog_annotations":[{"gene_uniquename":"YGR053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06256","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003285","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR053C"}


id: YGR054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03788":null,"YGR054W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03788","reference_uniquename":"PMID:29761456"}],"product":"Eukaryotic initiation factor eIF2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003286","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR054W"}


id: YGR055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MUP1","product":"High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; involved in both methionine and cysteine uptake; subject to transport-activity dependent, methionine-induced endocytosis, vacuolar delivery and degradation; starvation-induced endocytosis is transport-activity independent","secondary_identifier":"SGD:S000003287","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR055W"}


id: YGR056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03787":null,"YGR056W":null},"has_protein_features":false,"name":"RSC1","ortholog_annotations":[{"gene_uniquename":"YGR056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03787","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook; RSC1 has a paralog, RSC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003288","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR056W"}


id: YGR057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02231":null,"YGR057C":null},"has_protein_features":false,"name":"LST7","ortholog_annotations":[{"gene_uniquename":"YGR057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02231","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino acid stimulation; required for activation of TORC1 in response to amino acid stimulation; recruited to the vacuolar membrane during amino acid starvation and released from the membrane by TORC1; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003289","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR057C"}


id: YGR058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEF1","product":"Penta-EF-hand protein; required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly","secondary_identifier":"SGD:S000003290","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR058W"}


id: YGR059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPR3","product":"Sporulation-specific homolog of the CDC3/10/11/12 family of genes; septin protein involved in sporulation; regulated by ABFI; the yeast CDC3/10/11/12 family is a family of bud neck microfilament genes","secondary_identifier":"SGD:S000003291","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR059W"}


id: YGR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03018":null,"YGR060W":null},"has_protein_features":false,"name":"ERG25","ortholog_annotations":[{"gene_uniquename":"YGR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03018","reference_uniquename":"PMID:29761456"}],"product":"C-4 methyl sterol oxidase; catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol; human MSMO1 functionally complements the growth defect caused by repression of ERG25 expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003292","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR060W"}


id: YGR061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03355":null,"YGR061C":null},"has_protein_features":false,"name":"ADE6","ortholog_annotations":[{"gene_uniquename":"YGR061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03355","reference_uniquename":"PMID:29761456"}],"product":"Formylglycinamidine-ribonucleotide (FGAM)-synthetase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003293","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR061C"}


id: YGR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05302":null,"YGR062C":null},"has_protein_features":false,"name":"COX18","ortholog_annotations":[{"gene_uniquename":"YGR062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05302","reference_uniquename":"PMID:29761456"}],"product":"Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC; respiratory defect of the null mutant is functionally complemented by human COX18 carrying the N-terminal 54 amino acids of S. cerevisiae Cox18p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003294","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR062C"}


id: YGR063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00483":null,"YGR063C":null},"has_protein_features":false,"name":"SPT4","ortholog_annotations":[{"gene_uniquename":"YGR063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00483","reference_uniquename":"PMID:29761456"}],"product":"Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and along with RNAP I and II has multiple roles regulating transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; localizes to kinetochores and heterochromatin, influencing chromosomal dynamics and silencing; required for transcription through long trinucleotide repeats in ORFs and non-protein coding regions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003295","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR063C"}


id: YGR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C","secondary_identifier":"SGD:S000003296","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR064W"}


id: YGR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02779":null,"SJAG_02780":null,"YGR065C":null},"has_protein_features":false,"name":"VHT1","ortholog_annotations":[{"gene_uniquename":"YGR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02779","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02780","reference_uniquename":"PMID:29761456"}],"product":"High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003297","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR065C"}


id: YGR066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03385":null,"YGR066C":null},"has_protein_features":false,"name":"GID10","ortholog_annotations":[{"gene_uniquename":"YGR066C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03385","reference_uniquename":"PMID:29761456"}],"product":"Recognition component (N-recognin) of the Pro/N-degron pathway; recognizes and targets for degradation proteins with N-terminal degradation signals; expressed only under starvation or osmotic stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003298","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR066C"}


id: YGR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p","secondary_identifier":"SGD:S000003299","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR067C"}


id: YGR068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00803":null,"SJAG_01686":null,"YGR068C":null},"has_protein_features":false,"name":"ART5","ortholog_annotations":[{"gene_uniquename":"YGR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00803","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01686","reference_uniquename":"PMID:26896847"}],"product":"Protein proposed to regulate endocytosis of plasma membrane proteins; regulates by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane; SWAT-GFP and mCherry fusion proteins localize to the cytosol","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000003300","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR068C"}


id: YGR068W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with the uncharacterized ORF YGR068C","secondary_identifier":"SGD:S000028637","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR068W-A"}


id: YGR069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003301","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR069W"}


id: YGR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03705":null,"SJAG_04771":null,"YGR070W":null},"has_protein_features":false,"name":"ROM1","ortholog_annotations":[{"gene_uniquename":"YGR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03705","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04771","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP; ROM1 has a paralog, ROM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003302","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR070W"}


id: YGR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ENV11","product":"Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; ENV11 has a paralog, VID22, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003303","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR071C"}


id: YGR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04056":null,"YGR072W":null},"has_protein_features":false,"name":"UPF3","ortholog_annotations":[{"gene_uniquename":"YGR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04056","reference_uniquename":"PMID:29761456"}],"product":"Component of the nonsense-mediated mRNA decay (NMD) pathway; along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003304","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR072W"}


id: YGR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; extensively overlaps essential SMD1 gene encoding a U6 snRNP protein","secondary_identifier":"SGD:S000003305","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR073C"}


id: YGR074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00147":null,"YGR074W":null},"has_protein_features":false,"name":"SMD1","ortholog_annotations":[{"gene_uniquename":"YGR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00147","reference_uniquename":"PMID:29761456"}],"product":"Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; relocalizes to the cytosol in response to hypoxia; homolog of human Sm D1; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003306","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR074W"}


id: YGR075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01308":null,"YGR075C":null},"has_protein_features":false,"name":"PRP38","ortholog_annotations":[{"gene_uniquename":"YGR075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01308","reference_uniquename":"PMID:29761456"}],"product":"Unique component of the U4/U6.U5 tri-snRNP particle; tri-snRNP is required for conformational changes which result in the catalytic activation of the spliceosome; dispensable for spliceosome assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003307","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR075C"}


id: YGR076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02762":null,"YGR076C":null},"has_protein_features":false,"name":"MRPL25","ortholog_annotations":[{"gene_uniquename":"YGR076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02762","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003308","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR076C"}


id: YGR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05315":null,"YGR077C":null},"has_protein_features":false,"name":"PEX8","ortholog_annotations":[{"gene_uniquename":"YGR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05315","reference_uniquename":"PMID:29761456"}],"product":"Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003309","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR077C"}


id: YGR078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00505":null,"YGR078C":null},"has_protein_features":false,"name":"PAC10","ortholog_annotations":[{"gene_uniquename":"YGR078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00505","reference_uniquename":"PMID:29761456"}],"product":"Part of the heteromeric co-chaperone GimC/prefoldin complex; complex promotes efficient protein folding","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003310","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR078C"}


id: YGR079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; YGR079W is not an essential gene","secondary_identifier":"SGD:S000003311","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR079W"}


id: YGR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01993":null,"YGR080W":null},"has_protein_features":false,"name":"TWF1","ortholog_annotations":[{"gene_uniquename":"YGR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01993","reference_uniquename":"PMID:29761456"}],"product":"Twinfilin; highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton; coordinates actin filament severing and monomer sequestering at sites of rapid actin turnover; composed of two cofilin-like regions, stimulates actin depolymerization as does the mouse homolog, mTwf1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003312","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR080W"}


id: YGR081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04339":null,"YGR081C":null},"has_protein_features":false,"name":"SLX9","ortholog_annotations":[{"gene_uniquename":"YGR081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04339","reference_uniquename":"PMID:29761456"}],"product":"Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; binds G-quadruplex (G4) structures in DNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003313","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR081C"}


id: YGR082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03358":null,"YGR082W":null},"has_protein_features":false,"name":"TOM20","ortholog_annotations":[{"gene_uniquename":"YGR082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03358","reference_uniquename":"PMID:29761456"}],"product":"Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003314","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR082W"}


id: YGR083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02307":null,"YGR083C":null},"has_protein_features":false,"name":"GCD2","ortholog_annotations":[{"gene_uniquename":"YGR083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02307","reference_uniquename":"PMID:29761456"}],"product":"Delta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003315","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR083C"}


id: YGR084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MRP13","product":"Mitochondrial ribosomal protein of the small subunit","secondary_identifier":"SGD:S000003316","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR084C"}


id: YGR085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00465":null,"SJAG_02280":null,"YGR085C":null},"has_protein_features":false,"name":"RPL11B","ortholog_annotations":[{"gene_uniquename":"YGR085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00465","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02280","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003317","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR085C"}


id: YGR086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02626":null,"SJAG_02707":null,"YGR086C":null},"has_protein_features":false,"name":"PIL1","ortholog_annotations":[{"gene_uniquename":"YGR086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02626","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02707","reference_uniquename":"PMID:29761456"}],"product":"Eisosome core component; eisosomes are large immobile cell cortex structures associated with endocytosis; detected in phosphorylated state in mitochondria; phosphorylated on Thr233 upon Pkc1p hyperactivation in a Slt2p MAPK-dependent fashion; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; member of BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003318","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR086C"}


id: YGR087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02734":null,"SJAG_03743":null,"SJAG_04842":null,"YGR087C":null},"has_protein_features":false,"name":"PDC6","ortholog_annotations":[{"gene_uniquename":"YGR087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02734","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03743","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04842","reference_uniquename":"PMID:29761456"}],"product":"Minor isoform of pyruvate decarboxylase; decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003319","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR087C"}


id: YGR088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04823":null,"YGR088W":null},"has_protein_features":false,"name":"CTT1","ortholog_annotations":[{"gene_uniquename":"YGR088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04823","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003320","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR088W"}


id: YGR089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NNF2","product":"Protein that exhibits physical and genetic interactions with Rpb8p; Rpb8p is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation","secondary_identifier":"SGD:S000003321","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR089W"}


id: YGR090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03156":null,"YGR090W":null},"has_protein_features":false,"name":"UTP22","ortholog_annotations":[{"gene_uniquename":"YGR090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03156","reference_uniquename":"PMID:29761456"}],"product":"Component of the small-subunit processome; required for nuclear export of tRNAs; forms a complex with Rrp7p; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003322","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR090W"}


id: YGR091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04529":null,"YGR091W":null},"has_protein_features":false,"name":"PRP31","ortholog_annotations":[{"gene_uniquename":"YGR091W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04529","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor; component of the U4/U6-U5 snRNP complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003323","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR091W"}


id: YGR092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02736":null,"SJAG_04597":null,"YGR092W":null},"has_protein_features":false,"name":"DBF2","ortholog_annotations":[{"gene_uniquename":"YGR092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02736","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04597","reference_uniquename":"PMID:29761456"}],"product":"Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis; DBF2 has a paralog, DBF20, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003324","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR092W"}


id: YGR093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05212":null,"YGR093W":null},"has_protein_features":false,"name":"DRN1","ortholog_annotations":[{"gene_uniquename":"YGR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05212","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor that modulates turnover of branched RNAs by Dbr1p; interacts with spliceosomal components and branched RNA splicing products; enhances Dbr1p debranching in vitro; conserved protein with domain organization identical from yeast to human; N-terminal homology to Dbr1p N-terminus, but Dbr1p catalytic residues not conserved; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003325","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR093W"}


id: YGR094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00443":null,"SJAG_02428":null,"YGR094W":null},"has_protein_features":false,"name":"VAS1","ortholog_annotations":[{"gene_uniquename":"YGR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00443","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02428","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial and cytoplasmic valyl-tRNA synthetase; human homolog VARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003326","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR094W"}


id: YGR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04153":null,"YGR095C":null},"has_protein_features":false,"name":"RRP46","ortholog_annotations":[{"gene_uniquename":"YGR095C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04153","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003327","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR095C"}


id: YGR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00835":null,"YGR096W":null},"has_protein_features":false,"name":"TPC1","ortholog_annotations":[{"gene_uniquename":"YGR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00835","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial membrane transporter; mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003328","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR096W"}


id: YGR097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ASK10","product":"Regulator of the Fps1p glycerol channel; under nonstress conditions, binds to Fps1p to positively regulate glycerol transport; under osmotic stress, multiple phosphorylation by Hog1p causes Ask10p to dissociate from Fps1p; forms homodimers and heterodimerizes with paralog Rgc1p; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; associates with RNA polymerase II holoenzyme","secondary_identifier":"SGD:S000003329","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR097W"}


id: YGR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02542":null,"YGR098C":null},"has_protein_features":false,"name":"ESP1","ortholog_annotations":[{"gene_uniquename":"YGR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02542","reference_uniquename":"PMID:29761456"}],"product":"Separase/separin, a caspase-like cysteine protease; cleaves Mcd1p/Scc1p, a mitotic cohesin complex subunit, resulting in the dissociation of cohesin from chromatin and sister chromatid separation; cleaves meiotic-cohesin subunit Rec8p along chromosome arms in meiosis I and at centromeric sites during meiosis II; inhibits PP2A-Cdc55p to promote mitotic exit; inhibited by Pds1p (securin); relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003330","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR098C"}


id: YGR099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00112":null,"YGR099W":null},"has_protein_features":false,"name":"TEL2","ortholog_annotations":[{"gene_uniquename":"YGR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00112","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003331","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR099W"}


id: YGR100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00864":null,"SJAG_04013":null,"YGR100W":null},"has_protein_features":false,"name":"MDR1","ortholog_annotations":[{"gene_uniquename":"YGR100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00864","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04013","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003332","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR100W"}


id: YGR101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03121":null,"YGR101W":null},"has_protein_features":false,"name":"PCP1","ortholog_annotations":[{"gene_uniquename":"YGR101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03121","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial serine protease; required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003333","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR101W"}


id: YGR102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05560":null,"YGR102C":null},"has_protein_features":false,"name":"GTF1","ortholog_annotations":[{"gene_uniquename":"YGR102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05560","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003334","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR102C"}


id: YGR103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00882":null,"YGR103W":null},"has_protein_features":false,"name":"NOP7","ortholog_annotations":[{"gene_uniquename":"YGR103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00882","reference_uniquename":"PMID:29761456"}],"product":"Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G<sub>0</sub> and the initiation of cell proliferation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003335","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR103W"}


id: YGR104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04820":null,"YGR104C":null},"has_protein_features":false,"name":"SRB5","ortholog_annotations":[{"gene_uniquename":"YGR104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04820","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003336","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR104C"}


id: YGR105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01939":null,"YGR105W":null},"has_protein_features":false,"name":"VMA21","ortholog_annotations":[{"gene_uniquename":"YGR105W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01939","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; diverged ortholog of human XMEA (X-linked Myopathy with Excessive Autophagy); functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003337","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR105W"}


id: YGR106C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00771":null,"YGR106C":null},"has_protein_features":false,"name":"VOA1","ortholog_annotations":[{"gene_uniquename":"YGR106C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00771","reference_uniquename":"PMID:29761456"}],"product":"ER protein that functions in assembly of the V0 sector of V-ATPase; functions with other assembly factors; null mutation enhances the vacuolar ATPase (V-ATPase) deficiency of a vma21 mutant impaired in endoplasmic reticulum (ER) retrieval","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003338","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR106C"}


id: YGR107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003339","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR107W"}


id: YGR108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01401":null,"SJAG_04140":null,"YGR108W":null},"has_protein_features":false,"name":"CLB1","ortholog_annotations":[{"gene_uniquename":"YGR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01401","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04140","reference_uniquename":"PMID:29761456"}],"product":"B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB1 has a paralog, CLB2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003340","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR108W"}


id: YGR109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03525":null,"YGR109C":null},"has_protein_features":false,"name":"CLB6","ortholog_annotations":[{"gene_uniquename":"YGR109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03525","reference_uniquename":"PMID:26896847"}],"product":"B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1; CLB6 has a paralog, CLB5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000003341","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR109C"}


id: YGR110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04323":null,"YGR110W":null},"has_protein_features":false,"name":"CLD1","ortholog_annotations":[{"gene_uniquename":"YGR110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04323","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003342","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR110W"}


id: YGR111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","secondary_identifier":"SGD:S000003343","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR111W"}


id: YGR112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03046":null,"YGR112W":null},"has_protein_features":false,"name":"SHY1","ortholog_annotations":[{"gene_uniquename":"YGR112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03046","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein required for complex IV assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome; complex IV is also known as cytochrome c oxidase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003344","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR112W"}


id: YGR113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01224":null,"YGR113W":null},"has_protein_features":false,"name":"DAM1","ortholog_annotations":[{"gene_uniquename":"YGR113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01224","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Duo1p and Pse1p to connect the DASH complex with the microtubules (MT); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003345","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR113W"}


id: YGR114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6","secondary_identifier":"SGD:S000003346","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR114C"}


id: YGR115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C","secondary_identifier":"SGD:S000003347","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR115C"}


id: YGR116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04670":null,"YGR116W":null},"has_protein_features":false,"name":"SPT6","ortholog_annotations":[{"gene_uniquename":"YGR116W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04670","reference_uniquename":"PMID:29761456"}],"product":"Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for fidelity of promoter selection through maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within coding regions; required for H3K36 trimethylation but not dimethylation by Set2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003348","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR116W"}


id: YGR117C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000003349","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR117C"}


id: YGR118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01632":null,"SJAG_02682":null,"SJAG_03568":null,"YGR118W":null},"has_protein_features":false,"name":"RPS23A","ortholog_annotations":[{"gene_uniquename":"YGR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01632","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02682","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03568","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003350","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR118W"}


id: YGR119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02210":null,"YGR119C":null},"has_protein_features":false,"name":"NUP57","ortholog_annotations":[{"gene_uniquename":"YGR119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02210","reference_uniquename":"PMID:29761456"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003351","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR119C"}


id: YGR120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00578":null,"YGR120C":null},"has_protein_features":false,"name":"COG2","ortholog_annotations":[{"gene_uniquename":"YGR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00578","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; the components of the Golgi complex are Gog1p through Cog8p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003352","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR120C"}


id: YGR121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04136":null,"SJAG_04731":null,"YGR121C":null},"has_protein_features":false,"name":"MEP1","ortholog_annotations":[{"gene_uniquename":"YGR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04136","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04731","reference_uniquename":"PMID:29761456"}],"product":"Ammonium permease; belongs to Mep-Amt-Rh family of well-conserved ammonium (NH4+) transporters that includes the human Rh factors; expression is under the nitrogen catabolite repression regulation; activity regulated by TORC1 effectors, Npr1p and Par32p; human homolog RHCG complements yeast null mutant; mutations in human homolog RHCG implicated in metabolic acidosis; MEP1 has a paralog, MEP3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003353","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR121C"}


id: YGR121W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028550","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR121W-A"}


id: YGR122C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; similar to YLR334C and YOL106W","secondary_identifier":"SGD:S000007240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR122C-A"}


id: YGR122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress","secondary_identifier":"SGD:S000003354","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR122W"}


id: YGR123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02854":null,"YGR123C":null},"has_protein_features":false,"name":"PPT1","ortholog_annotations":[{"gene_uniquename":"YGR123C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02854","reference_uniquename":"PMID:29761456"}],"product":"Protein serine/threonine phosphatase; regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003355","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR123C"}


id: YGR124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04549":null,"YGR124W":null},"has_protein_features":false,"name":"ASN2","ortholog_annotations":[{"gene_uniquename":"YGR124W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04549","reference_uniquename":"PMID:29761456"}],"product":"Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003356","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR124W"}


id: YGR125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00877":null,"YGR125W":null},"has_protein_features":false,"name":"VSB1","ortholog_annotations":[{"gene_uniquename":"YGR125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00877","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane protein required for uptake and storage of arginine in nitrogen-replete cells; nitrogen starvation appears to inhibit Vsb1-dependent activity, resulting in mobilization of stored vacuolar arginine to the cytosol; arginine uptake appears to be driven by a V-ATPase mediated H+ gradient; member of the APC (amino acid-polyamine-organocation) transporter superfamily","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003357","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR125W"}


id: YGR126W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000003358","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR126W"}


id: YGR127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response","secondary_identifier":"SGD:S000003359","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR127W"}


id: YGR128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03341":null,"YGR128C":null},"has_protein_features":false,"name":"UTP8","ortholog_annotations":[{"gene_uniquename":"YGR128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03341","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003360","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR128C"}


id: YGR129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02844":null,"YGR129W":null},"has_protein_features":false,"name":"SYF2","ortholog_annotations":[{"gene_uniquename":"YGR129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02844","reference_uniquename":"PMID:29761456"}],"product":"Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; relocalizes to the cytosol in response to hypoxia; isy1 syf2 cells have defective spindles activiating cell cycle arrest","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003361","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR129W"}


id: YGR130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)","secondary_identifier":"SGD:S000003362","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR130C"}


id: YGR131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02338":null,"YGR131W":null},"has_protein_features":false,"name":"FHN1","ortholog_annotations":[{"gene_uniquename":"YGR131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02338","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain; FHN1 has a paralog, NCE102, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003363","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR131W"}


id: YGR132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00079":null,"YGR132C":null},"has_protein_features":false,"name":"PHB1","ortholog_annotations":[{"gene_uniquename":"YGR132C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00079","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003364","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR132C"}


id: YGR133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04857":null,"YGR133W":null},"has_protein_features":false,"name":"PEX4","ortholog_annotations":[{"gene_uniquename":"YGR133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04857","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal ubiquitin conjugating enzyme; required for peroxisomal matrix protein import and peroxisome biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003365","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR133W"}


id: YGR134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CAF130","product":"Subunit of the CCR4-NOT transcriptional regulatory complex; CCR4-NOT complex is evolutionarily-conserved and involved in controlling mRNA initiation, elongation, and degradation","secondary_identifier":"SGD:S000003366","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR134W"}


id: YGR135W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00808":null,"YGR135W":null},"has_protein_features":false,"name":"PRE9","ortholog_annotations":[{"gene_uniquename":"YGR135W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00808","reference_uniquename":"PMID:29761456"}],"product":"Alpha 3 subunit of the 20S proteasome; the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003367","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR135W"}


id: YGR136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04554":null,"YGR136W":null},"has_protein_features":false,"name":"LSB1","ortholog_annotations":[{"gene_uniquename":"YGR136W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04554","reference_uniquename":"PMID:29761456"}],"product":"Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003368","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR136W"}


id: YGR137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003369","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR137W"}


id: YGR138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02344":null,"YGR138C":null},"has_protein_features":false,"name":"TPO2","ortholog_annotations":[{"gene_uniquename":"YGR138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02344","reference_uniquename":"PMID:29761456"}],"product":"Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003370","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR138C"}


id: YGR139W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003371","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR139W"}


id: YGR140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CBF2","product":"Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; sumoylated in an Mms21p-dependent manner; relative distribution to the spindle pole body decreases upon DNA replication stress","secondary_identifier":"SGD:S000003372","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR140W"}


id: YGR141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"VPS62","product":"Vacuolar protein sorting (VPS) protein; required for cytoplasm to vacuole targeting of proteins; VPS62 has a paralog, TDA6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003373","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR141W"}


id: YGR142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BTN2","product":"v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; contributes to prion curing; preferentially expressed after severe ethanol stress","secondary_identifier":"SGD:S000003374","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR142W"}


id: YGR143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02446":null,"SJAG_02590":null,"SJAG_04690":null,"YGR143W":null},"has_protein_features":false,"name":"SKN1","ortholog_annotations":[{"gene_uniquename":"YGR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02446","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02590","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04690","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in sphingolipid biosynthesis; type II membrane protein; SKN1 has a paralog, KRE6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003375","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR143W"}


id: YGR144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00827":null,"YGR144W":null},"has_protein_features":false,"name":"THI4","ortholog_annotations":[{"gene_uniquename":"YGR144W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00827","reference_uniquename":"PMID:29761456"}],"product":"Thiazole synthase; abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003376","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR144W"}


id: YGR145W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04033":null,"YGR145W":null},"has_protein_features":false,"name":"ENP2","ortholog_annotations":[{"gene_uniquename":"YGR145W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04033","reference_uniquename":"PMID:29761456"}],"product":"Component of the SSU; required for pre-18S rRNA processing, biogenesis of the small ribosomal subunit; interacts with U3 snoRNA, Mpp10p and Bfr2p; contains WD repeats, and has homology to Spb1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003377","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR145W"}


id: YGR146C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03974":null,"YGR146C":null},"has_protein_features":false,"name":"ECL1","ortholog_annotations":[{"gene_uniquename":"YGR146C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03974","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR146C"}


id: YGR146C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR146C-A"}


id: YGR147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_07016":null,"YGR147C":null},"has_protein_features":false,"name":"NAT2","ortholog_annotations":[{"gene_uniquename":"YGR147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07016","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; has an apparent role in acetylation of N-terminal methionine residues","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR147C"}


id: YGR148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02243":null,"SJAG_03922":null,"YGR148C":null},"has_protein_features":false,"name":"RPL24B","ortholog_annotations":[{"gene_uniquename":"YGR148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02243","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03922","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR148C"}


id: YGR149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03154":null,"YGR149W":null},"has_protein_features":false,"name":"GPC1","ortholog_annotations":[{"gene_uniquename":"YGR149W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03154","reference_uniquename":"PMID:29761456"}],"product":"Glycerophosphocholine acyltransferase (GPCAT); involved in in phosphatidylcholine (PC) synthesis; uses acyl-CoA to acylate glycero-3-phosphocholine to yield lyso-PC; also catalyzes acylation of glycerophosphoethanolamine with acyl-CoA; predicted to be an integral membrane protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR149W"}


id: YGR150C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02217":null,"YGR150C":null},"has_protein_features":false,"name":"CCM1","ortholog_annotations":[{"gene_uniquename":"YGR150C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02217","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial 15S rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; has separable roles in stabilizing mitochondrial 15S rRNA and in maturation of the COB and COX1 mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR150C"}


id: YGR151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000003383","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR151C"}


id: YGR152C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RSR1","product":"Ras-type GTPase; required for bud site selection during both axial and bipolar budding, for morphological changes in response to mating pheromone, and for efficient cell fusion; recruits Cdc24p to the incipient bud site, activating its guanyl-nucleotide exchange factor activity and the Rho-like GTPase, Cdc42p; localizes to the plasma membrane, the incipient bud site, polarized growth sites, the cell division site and the vacuole membrane; Ras superfamily member similar to mammalian Rap GTPases","secondary_identifier":"SGD:S000003384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR152C"}


id: YGR153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000003385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR153W"}


id: YGR154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GTO1","product":"Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization","secondary_identifier":"SGD:S000003386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR154C"}


id: YGR155W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CYS4","product":"Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria; human CBS can complement yeast null mutant","secondary_identifier":"SGD:S000003387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR155W"}


id: YGR156W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PTI1","product":"Essential component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; relocalizes to the cytosol in response to hypoxia; similar to mammalian Cleavage-Stimulation Factor CstF-64","secondary_identifier":"SGD:S000003388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR156W"}


id: YGR157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00825":null,"YGR157W":null},"has_protein_features":false,"name":"CHO2","ortholog_annotations":[{"gene_uniquename":"YGR157W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00825","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylethanolamine methyltransferase (PEMT); catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR157W"}


id: YGR158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00854":null,"YGR158C":null},"has_protein_features":false,"name":"MTR3","ortholog_annotations":[{"gene_uniquename":"YGR158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00854","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR158C"}


id: YGR159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00259":null,"YGR159C":null},"has_protein_features":false,"name":"NSR1","ortholog_annotations":[{"gene_uniquename":"YGR159C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00259","reference_uniquename":"PMID:29761456"}],"product":"Nucleolin, nucleolar protein that binds nuclear localization sequences; required for pre-rRNA processing and ribosome biogenesis; binds to single stranded telomeric DNA and mRNA; binds to G-quadruplex DNA; methylated by Hmt1p; interaction with Top1p and nucleolar localization are negatively regulated by polyphosphorylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR159C"}


id: YGR160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR160W"}


id: YGR161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RTS3","product":"Putative component of the protein phosphatase type 2A complex","secondary_identifier":"SGD:S000003393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR161C"}


id: YGR161W-C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species","secondary_identifier":"SGD:S000029726","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR161W-C"}


id: YGR162W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01954":null,"YGR162W":null},"has_protein_features":false,"name":"TIF4631","ortholog_annotations":[{"gene_uniquename":"YGR162W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01954","reference_uniquename":"PMID:29761456"}],"product":"Translation initiation factor eIF4G and scaffold protein; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E (Cdc33p) and eIF4A (Tif1p/Tif2p); stimulates the ATPase and helicase activities of eIF4A synergistically with eIF4G; required with eIF4E for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; association with Pab1p mediates poly(A) tail-stimulated translation; role in biogenesis of the 60S ribosomal subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003394","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR162W"}


id: YGR163W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03371":null,"YGR163W":null},"has_protein_features":false,"name":"GTR2","ortholog_annotations":[{"gene_uniquename":"YGR163W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03371","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex; subunit of Gtr1-Gtr2, a GTPase that activates TORC1 in response to amino acid stimulation; negatively regulates the GTPase cycle of Gtr1p, a Ran/TC4 homolog; subunit of EGO, a vacuolar/endosomal membrane complex that regulates exit from rapamycin-induced growth arrest and endosome to plasma membrane sorting of Gap1p; activates transcription when chromatin bound; activated by the Lst4p-Lst7p GAP complex; homolog of human RagC","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003395","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR163W"}


id: YGR164W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000003396","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR164W"}


id: YGR165W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02067":null,"YGR165W":null},"has_protein_features":false,"name":"MRPS35","ortholog_annotations":[{"gene_uniquename":"YGR165W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02067","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003397","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR165W"}


id: YGR166W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03663":null,"YGR166W":null},"has_protein_features":false,"name":"TRS65","ortholog_annotations":[{"gene_uniquename":"YGR166W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03663","reference_uniquename":"PMID:29761456"}],"product":"Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; role in cell wall beta-glucan biosynthesis and the stress response","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003398","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR166W"}


id: YGR167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04517":null,"YGR167W":null},"has_protein_features":false,"name":"CLC1","ortholog_annotations":[{"gene_uniquename":"YGR167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04517","reference_uniquename":"PMID:29761456"}],"product":"Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; regulates endocytic progression; thought to regulate clathrin function; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003399","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR167W"}


id: YGR168C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEX35","product":"Regulator of peroxisome abundance; peroxisomal membrane protein, remote homolog to several curvature-generating human proteins; functionally interacts with vesicle-budding-inducing ADP-ribosylation factor Arf1p","secondary_identifier":"SGD:S000003400","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR168C"}


id: YGR169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PUS6","product":"tRNA:pseudouridine synthase; catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability","secondary_identifier":"SGD:S000003401","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR169C"}


id: YGR169C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03924":null,"YGR169C-A":null},"has_protein_features":false,"name":"LSO2","ortholog_annotations":[{"gene_uniquename":"YGR169C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03924","reference_uniquename":"PMID:29761456"}],"product":"Ribosome-associated protein; required for global translational elongation after recovery from stationary phase due to starvation; crosslinks to the 25S rRNA near the A site that overlaps the GTPase activation center, and to tRNAs; possible role in the iron deprivation response; localizes to the nucleus and cytoplasm, with enhanced nuclear localization under iron-replete conditions; null mutant exhibits slow growth during iron deprivation; orthologous to human CCDC124","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR169C-A"}


id: YGR170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02902":null,"YGR170W":null},"has_protein_features":false,"name":"PSD2","ortholog_annotations":[{"gene_uniquename":"YGR170W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02902","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes; converts phosphatidylserine to phosphatidylethanolamine; controls vacuolar membrane phospholipid content by regulating phospholipids in compartments that will eventually give rise to the vacuole; loss of Psd2p causes a specific reduction in vacuolar membrane PE levels while total PE levels are not significantly affected","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003402","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR170W"}


id: YGR171C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_16456":null,"YGR171C":null},"has_protein_features":false,"name":"MSM1","ortholog_annotations":[{"gene_uniquename":"YGR171C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16456","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial methionyl-tRNA synthetase (MetRS); functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003403","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR171C"}


id: YGR172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03670":null,"YGR172C":null},"has_protein_features":false,"name":"YIP1","ortholog_annotations":[{"gene_uniquename":"YGR172C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03670","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein; required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; human homolog YIPF5 can complement yeast yip1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003404","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR172C"}


id: YGR173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02331":null,"YGR173W":null},"has_protein_features":false,"name":"RBG2","ortholog_annotations":[{"gene_uniquename":"YGR173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02331","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003405","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR173W"}


id: YGR174C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05305":null,"YGR174C":null},"has_protein_features":false,"name":"CBP4","ortholog_annotations":[{"gene_uniquename":"YGR174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05305","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003406","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR174C"}


id: YGR174W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; predicted to have a role in cell budding based on computational 'guilt by association' analysis","secondary_identifier":"SGD:S000028639","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR174W-A"}


id: YGR175C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00370":null,"YGR175C":null},"has_protein_features":false,"name":"ERG1","ortholog_annotations":[{"gene_uniquename":"YGR175C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00370","reference_uniquename":"PMID:29761456"}],"product":"Squalene epoxidase; catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine; human SQLE functionally complements the lethality of the erg1 null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003407","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR175C"}


id: YGR176W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003408","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR176W"}


id: YGR177C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATF2","product":"Alcohol acetyltransferase; may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking","secondary_identifier":"SGD:S000003409","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR177C"}


id: YGR178C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01317":null,"YGR178C":null},"has_protein_features":false,"name":"PBP1","ortholog_annotations":[{"gene_uniquename":"YGR178C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01317","reference_uniquename":"PMID:29761456"}],"product":"Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; regulates TORC1 signaling and autophagy; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; similar to human ataxin-2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003410","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR178C"}


id: YGR179C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01928":null,"YGR179C":null},"has_protein_features":false,"name":"OKP1","ortholog_annotations":[{"gene_uniquename":"YGR179C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01928","reference_uniquename":"PMID:29761456"}],"product":"Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003411","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR179C"}


id: YGR180C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00885":null,"YGR180C":null},"has_protein_features":false,"name":"RNR4","ortholog_annotations":[{"gene_uniquename":"YGR180C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00885","reference_uniquename":"PMID:29761456"}],"product":"Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress; RNR4 has a paralog, RNR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003412","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR180C"}


id: YGR181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01949":null,"YGR181W":null},"has_protein_features":false,"name":"TIM13","ortholog_annotations":[{"gene_uniquename":"YGR181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01949","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial intermembrane space protein; forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003413","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR181W"}


id: YGR182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W","secondary_identifier":"SGD:S000003414","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR182C"}


id: YGR183C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01763":null,"YGR183C":null},"has_protein_features":false,"name":"QCR9","ortholog_annotations":[{"gene_uniquename":"YGR183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01763","reference_uniquename":"PMID:29761456"}],"product":"Subunit 9 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003415","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR183C"}


id: YGR184C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01253":null,"SJAG_04619":null,"YGR184C":null},"has_protein_features":false,"name":"UBR1","ortholog_annotations":[{"gene_uniquename":"YGR184C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01253","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR184C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04619","reference_uniquename":"PMID:29761456"}],"product":"E3 Ub-ligase (N-recognin); recognizes and ubiquitinates N-end rule pathway substrates in complex with Rad6p; Roq1p-bound form accelerates degradation of misfolded and native ER membrane and cytosolic proteins as part of the stress-induced homeostatically regulated protein degradation (SHRED) pathway; role in ER-associated protein degradation; modifies Cup9p to regulate peptide transport; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003416","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR184C"}


id: YGR185C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00243":null,"YGR185C":null},"has_protein_features":false,"name":"TYS1","ortholog_annotations":[{"gene_uniquename":"YGR185C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00243","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; human ortholog YARS functionally complements the heat sensitivity of a ts allele; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003417","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR185C"}


id: YGR186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00095":null,"YGR186W":null},"has_protein_features":false,"name":"TFG1","ortholog_annotations":[{"gene_uniquename":"YGR186W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00095","reference_uniquename":"PMID:29761456"}],"product":"TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003418","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR186W"}


id: YGR187C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02014":null,"YGR187C":null},"has_protein_features":false,"name":"HGH1","ortholog_annotations":[{"gene_uniquename":"YGR187C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02014","reference_uniquename":"PMID:29761456"}],"product":"Chaperone protein for translation factor eEF2; involved in biogenesis of eukaryotic Elongation Factor 2 (Eft1p, Eft2p); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003419","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR187C"}


id: YGR188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01082":null,"SJAG_04699":null,"YGR188C":null},"has_protein_features":false,"name":"BUB1","ortholog_annotations":[{"gene_uniquename":"YGR188C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01082","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR188C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04699","reference_uniquename":"PMID:26896847"}],"product":"Protein kinase involved in the cell cycle checkpoint into anaphase; in complex with Mad1p and Bub3p, prevents progression into anaphase in presence of spindle damage; Cdc28p-mediated phosphorylation at Bub1p-T566 is important for degradation in anaphase and adaptation of checkpoint to prolonged mitotic arrest; associates with centromere DNA via Skp1p; involved in Sgo1p relocalization in response to sister kinetochore tension; paralog MAD3 arose from whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003420","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR188C"}


id: YGR189C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04327":null,"YGR189C":null},"has_protein_features":false,"name":"CRH1","ortholog_annotations":[{"gene_uniquename":"YGR189C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04327","reference_uniquename":"PMID:29761456"}],"product":"Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR189C"}


id: YGR190C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W","secondary_identifier":"SGD:S000003422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR190C"}


id: YGR191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YGR191W":null},"has_protein_features":false,"name":"HIP1","ortholog_annotations":[{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"High-affinity histidine permease; also involved in the transport of manganese ions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR191W"}


id: YGR192C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00027":null,"SJAG_02135":null,"SJAG_02945":null,"SJAG_03828":null,"SJAG_03903":null,"SJAG_06621":null,"SJAG_06622":null,"YGR192C":null},"has_protein_features":false,"name":"TDH3","ortholog_annotations":[{"gene_uniquename":"YGR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00027","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02135","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02945","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03828","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03903","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06621","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06622","reference_uniquename":"PMID:29761456"}],"product":"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bacteria; binds AU-rich RNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003424","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR192C"}


id: YGR193C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00866":null,"YGR193C":null},"has_protein_features":false,"name":"PDX1","ortholog_annotations":[{"gene_uniquename":"YGR193C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00866","reference_uniquename":"PMID:29761456"}],"product":"E3-binding protein of the mitochondrial pyruvate dehydrogenase complex; plays a structural role in the complex by binding and positioning dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide acetyltransferase (E2) core","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR193C"}


id: YGR194C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04276":null,"YGR194C":null},"has_protein_features":false,"name":"XKS1","ortholog_annotations":[{"gene_uniquename":"YGR194C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04276","reference_uniquename":"PMID:29761456"}],"product":"Xylulokinase; converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003426","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR194C"}


id: YGR195W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03179":null,"YGR195W":null},"has_protein_features":false,"name":"SKI6","ortholog_annotations":[{"gene_uniquename":"YGR195W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03179","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003427","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR195W"}


id: YGR196C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02223":null,"YGR196C":null},"has_protein_features":false,"name":"FYV8","ortholog_annotations":[{"gene_uniquename":"YGR196C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02223","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; required for survival upon exposure to K1 killer toxin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003428","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR196C"}


id: YGR197C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNG1","product":"Protein involved in resistance to nitrosoguanidine and 6-azauracil; expression is regulated by transcription factors involved in multidrug resistance; SNG1 has a paralog, YJR015W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR197C"}


id: YGR198W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00137":null,"SJAG_04053":null,"YGR198W":null},"has_protein_features":false,"name":"YPP1","ortholog_annotations":[{"gene_uniquename":"YGR198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00137","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04053","reference_uniquename":"PMID:26896847"}],"product":"Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4p; is required, along with Efr3p, for the assembly and recruitment of multiple copies of the kinase into phosphoinositide kinase (PIK) patches at the plasma membrane; positively regulates Stt4p; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003430","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR198W"}


id: YGR199W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04053":null,"YGR199W":null},"has_protein_features":false,"name":"PMT6","ortholog_annotations":[{"gene_uniquename":"YGR199W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04053","reference_uniquename":"PMID:29761456"}],"product":"Protein O-mannosyltransferase; transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR199W"}


id: YGR200C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04704":null,"YGR200C":null},"has_protein_features":false,"name":"ELP2","ortholog_annotations":[{"gene_uniquename":"YGR200C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04704","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Elongator complex; binds to microtubules via conserved alkaline residues; has two seven-bladed WD40 &#946; propellers; Elongator complex is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003432","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR200C"}


id: YGR201C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02017":null,"SJAG_03863":null,"YGR201C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR201C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02017","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR201C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03863","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003433","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR201C"}


id: YGR202C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00946":null,"YGR202C":null},"has_protein_features":false,"name":"PCT1","ortholog_annotations":[{"gene_uniquename":"YGR202C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00946","reference_uniquename":"PMID:29761456"}],"product":"Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; controls phosphatidylcholine homeostasis; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR202C"}


id: YGR203W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04166":null,"YGR203W":null},"has_protein_features":false,"name":"YCH1","ortholog_annotations":[{"gene_uniquename":"YGR203W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04166","reference_uniquename":"PMID:29761456"}],"product":"Phosphatase with sequence similarity to Mih1p; member of the Cdc25p subfamily of tyrosine phosphatases and Arr2p, an arsenate reductase, based on the presence of a rhodanese-homology domain; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR203W"}


id: YGR204C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028640","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR204C-A"}


id: YGR204W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00106":null,"SJAG_04156":null,"YGR204W":null},"has_protein_features":false,"name":"ADE3","ortholog_annotations":[{"gene_uniquename":"YGR204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00106","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04156","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic trifunctional enzyme; catalyzes sequential reactions 10-formyl-THF synthetase (EC 6.3.4.3), 5,10-methenyl-THF cyclohydrolase (EC 3.5.4.9), and 5,10-methylene-THF dehydrogenase (EC 1.5.1.5), to supply forms of activated one-carbon units required for biosynthesis of purines, histidine, methionine, pantothenic acid, the formyl group of mitochondrial fMet-tRNAfMet, and the methyl group of thymidylate; null mutation causes auxotrophy for adenine and histidine in rich medium","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003436","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR204W"}


id: YGR205W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03017":null,"YGR205W":null},"has_protein_features":false,"name":"TDA10","ortholog_annotations":[{"gene_uniquename":"YGR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03017","reference_uniquename":"PMID:29761456"}],"product":"ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003437","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR205W"}


id: YGR206W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MVB12","product":"ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers; the ESCRT-I core complex (Stp22p, Vps28p, Srn2p) is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin","secondary_identifier":"SGD:S000003438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR206W"}


id: YGR207C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CIR1","product":"Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response","secondary_identifier":"SGD:S000003439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR207C"}


id: YGR208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04449":null,"YGR208W":null},"has_protein_features":false,"name":"SER2","ortholog_annotations":[{"gene_uniquename":"YGR208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04449","reference_uniquename":"PMID:29761456"}],"product":"Phosphoserine phosphatase of the phosphoglycerate pathway; involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003440","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR208W"}


id: YGR209C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04953":null,"YGR209C":null},"has_protein_features":false,"name":"TRX2","ortholog_annotations":[{"gene_uniquename":"YGR209C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04953","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system that protects cells from oxidative and reductive stress; subunit of the LMA1 complex, with Pbi2p, that promotes vacuole inheritance; cofactor for Tsa1p; required for ER-Golgi transport; facilitates mitochondrial import of small Tims (Tim9p, Tim10p, Tim13p) by maintaining them in reduced form along with Trx1p; component of a signal transduction redox relay in a light sensing pathway; abundance increases under DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR209C"}


id: YGR210C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02604":null,"YGR210C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR210C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02604","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003442","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR210C"}


id: YGR211W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02461":null,"YGR211W":null},"has_protein_features":false,"name":"ZPR1","ortholog_annotations":[{"gene_uniquename":"YGR211W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02461","reference_uniquename":"PMID:29761456"}],"product":"Essential protein with two zinc fingers; present in nucleus of growing cells, relocates to cytoplasm in starved cells via a process mediated by Cpr1p; binds translation elongation factor eEF-1 (Tef1p); relative distribution to nucleus increases upon DNA replication stress; human ZPR1 gene can complement yeast by allowing growth during down-regulation of yeast zpr1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003443","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR211W"}


id: YGR212W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SLI1","product":"N-acetyltransferase; confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin","secondary_identifier":"SGD:S000003444","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR212W"}


id: YGR213C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00018":null,"SJAG_00587":null,"SJAG_00589":null,"SJAG_01095":null,"SJAG_02114":null,"SJAG_02132":null,"SJAG_02581":null,"SJAG_02943":null,"SJAG_02957":null,"YGR213C":null},"has_protein_features":false,"name":"RTA1","ortholog_annotations":[{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00018","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00587","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00589","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01095","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02114","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02132","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02581","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02943","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02957","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein; RTA1 has a paralog, YLR046C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003445","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR213C"}


id: YGR214W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02184":null,"SJAG_02479":null,"SJAG_02803":null,"YGR214W":null},"has_protein_features":false,"name":"RPS0A","ortholog_annotations":[{"gene_uniquename":"YGR214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02184","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02479","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02803","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003446","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR214W"}


id: YGR215W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03065":null,"YGR215W":null},"has_protein_features":false,"name":"RSM27","ortholog_annotations":[{"gene_uniquename":"YGR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03065","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003447","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR215W"}


id: YGR216C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03066":null,"YGR216C":null},"has_protein_features":false,"name":"GPI1","ortholog_annotations":[{"gene_uniquename":"YGR216C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03066","reference_uniquename":"PMID:29761456"}],"product":"Membrane protein involved in the synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1 are functional homologs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003448","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR216C"}


id: YGR217W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05229":null,"YGR217W":null},"has_protein_features":false,"name":"CCH1","ortholog_annotations":[{"gene_uniquename":"YGR217W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05229","reference_uniquename":"PMID:29761456"}],"product":"Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and partially co-localizes with Mid1p; however, evidence suggests CCH1 is not required for Mid1p function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003449","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR217W"}


id: YGR218W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01358":null,"YGR218W":null},"has_protein_features":false,"name":"CRM1","ortholog_annotations":[{"gene_uniquename":"YGR218W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01358","reference_uniquename":"PMID:29761456"}],"product":"Nuclear export factor, exportin; major karyopherin involved in export of proteins, RNAs, and ribosomal subunits from the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003450","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR218W"}


id: YGR219W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C","secondary_identifier":"SGD:S000003451","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR219W"}


id: YGR220C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01413":null,"YGR220C":null},"has_protein_features":false,"name":"MRPL9","ortholog_annotations":[{"gene_uniquename":"YGR220C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01413","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003452","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR220C"}


id: YGR221C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TOS2","product":"Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p; TOS2 has a paralog, SKG6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003453","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR221C"}


id: YGR222W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PET54","product":"Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing; also stimulates efficient synthesis of Cox1p","secondary_identifier":"SGD:S000003454","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR222W"}


id: YGR223C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00115":null,"YGR223C":null},"has_protein_features":false,"name":"HSV2","ortholog_annotations":[{"gene_uniquename":"YGR223C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00115","reference_uniquename":"PMID:29761456"}],"product":"Phosphoinositide (PI) binding protein; involved in micronucleophagy; belongs to the PROPPIN family of proteins defined by a seven-bladed beta-propeller fold and FRRG motif required for PI binding; displays punctate cytoplasmic localization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR223C"}


id: YGR224W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01336":null,"SJAG_01636":null,"SJAG_01923":null,"SJAG_04715":null,"SJAG_04983":null,"YGR224W":null},"has_protein_features":false,"name":"AZR1","ortholog_annotations":[{"gene_uniquename":"YGR224W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01336","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR224W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01636","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR224W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01923","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR224W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04715","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR224W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04983","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane transporter of the major facilitator superfamily; involved in resistance to azole drugs such as ketoconazole and fluconazole","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003456","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR224W"}


id: YGR225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03809":null,"SJAG_03858":null,"YGR225W":null},"has_protein_features":false,"name":"AMA1","ortholog_annotations":[{"gene_uniquename":"YGR225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03809","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGR225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03858","reference_uniquename":"PMID:29761456"}],"product":"Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis; prevents premature assembly of the meiosis I spindle, required for DSB induced prophase I arrest","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003457","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR225W"}


id: YGR226C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W","secondary_identifier":"SGD:S000003458","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR226C"}


id: YGR227C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OTO1","product":"Small toxic protein; overexpression inhibits ergosterol biosynthesis; not required for normal growth, not conserved in related yeast species including S. paradoxus","secondary_identifier":"SGD:S000303806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR227C-A"}


id: YGR227W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03764":null,"YGR227W":null},"has_protein_features":false,"name":"DIE2","ortholog_annotations":[{"gene_uniquename":"YGR227W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03764","reference_uniquename":"PMID:29761456"}],"product":"Dolichyl-phosphoglucose-dependent alpha-1,2-glucosyltransferase; located in the ER; functions in pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation; has a role in regulation of ITR1 and INO1; human homolog ALG10B can complement yeast die2 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003459","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR227W"}


id: YGR228W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C","secondary_identifier":"SGD:S000003460","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR228W"}


id: YGR229C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03123":null,"YGR229C":null},"has_protein_features":false,"name":"SMI1","ortholog_annotations":[{"gene_uniquename":"YGR229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03123","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003461","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR229C"}


id: YGR230W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01341":null,"YGR230W":null},"has_protein_features":false,"name":"BNS1","ortholog_annotations":[{"gene_uniquename":"YGR230W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01341","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; FEAR network component that partially overlaps the function of SPO12 in promoting Cdc14p release from the nucleolus during early mitotic anaphase and mitotic exit; overexpression partially suppresses the meiotic defect of spo12; BNS1 has a paralog, SPO12, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003462","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR230W"}


id: YGR231C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01073":null,"YGR231C":null},"has_protein_features":false,"name":"PHB2","ortholog_annotations":[{"gene_uniquename":"YGR231C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01073","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003463","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR231C"}


id: YGR232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00954":null,"YGR232W":null},"has_protein_features":false,"name":"NAS6","ortholog_annotations":[{"gene_uniquename":"YGR232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00954","reference_uniquename":"PMID:29761456"}],"product":"Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, also known as p28, which interacts with the Rb tumor suppressor and CDK4/6","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003464","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR232W"}


id: YGR233C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PHO81","product":"Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000003465","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR233C"}


id: YGR234W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YHB1","product":"Nitric oxide oxidoreductase; flavohemoglobin that plays role in oxidative and nitrosative stress responses; protects against nitration of cellular targets and against cell growth inhibition under aerobic or anaerobic conditions; yeast flavohemoglobin Yhb1p and human homolog neuroglobin NGB protect cells against alpha-synuclein cytotoxicity and aggregate formation; protein increases in abundance, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","secondary_identifier":"SGD:S000003466","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR234W"}


id: YGR235C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02501":null,"YGR235C":null},"has_protein_features":false,"name":"MIC26","ortholog_annotations":[{"gene_uniquename":"YGR235C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02501","reference_uniquename":"PMID:29761456"}],"product":"Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic26p is a non-essential component of the complex; orthologous to human APOO and APOOL","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003467","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR235C"}


id: YGR236C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPG1","product":"Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000003468","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR236C"}


id: YGR237C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000003469","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR237C"}


id: YGR238C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01196":null,"SJAG_04322":null,"YGR238C":null},"has_protein_features":false,"name":"KEL2","ortholog_annotations":[{"gene_uniquename":"YGR238C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01196","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR238C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04322","reference_uniquename":"PMID:29761456"}],"product":"Protein that negatively regulates mitotic exit; forms a complex with Kel1p and Bud14p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; functions in a complex with Kel1p, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003470","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR238C"}


id: YGR239C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEX21","product":"Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; constitutively expressed; partially redundant with Pex18p; required for import of the Gpd1p-Pnc1p heterodimer in which only Gpd1p has a peroxisomal targeting signal; relative distribution to cytoplasmic foci increases upon DNA replication stress","secondary_identifier":"SGD:S000003471","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR239C"}


id: YGR240C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00605":null,"YGR240C":null},"has_protein_features":false,"name":"PFK1","ortholog_annotations":[{"gene_uniquename":"YGR240C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00605","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of heterooctameric phosphofructokinase; involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR240C"}


id: YGR240C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028551","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR240C-A"}


id: YGR241C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01748":null,"YGR241C":null},"has_protein_features":false,"name":"YAP1802","ortholog_annotations":[{"gene_uniquename":"YGR241C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01748","reference_uniquename":"PMID:29761456"}],"product":"Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003473","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR241C"}


id: YGR242W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C","secondary_identifier":"SGD:S000003474","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR242W"}


id: YGR243W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04593":null,"YGR243W":null},"has_protein_features":false,"name":"MPC3","ortholog_annotations":[{"gene_uniquename":"YGR243W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04593","reference_uniquename":"PMID:29761456"}],"product":"Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on nonfermentable carbon sources, and heterodimerizes with Mpc1p to form the respiratory isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC3 paralog, MPC2, heterodimerizes with Mpc1p to form the fermentative MPC isoform; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003475","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR243W"}


id: YGR244C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03813":null,"YGR244C":null},"has_protein_features":false,"name":"LSC2","ortholog_annotations":[{"gene_uniquename":"YGR244C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03813","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003476","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR244C"}


id: YGR245C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04308":null,"YGR245C":null},"has_protein_features":false,"name":"SDA1","ortholog_annotations":[{"gene_uniquename":"YGR245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04308","reference_uniquename":"PMID:29761456"}],"product":"Protein required for actin organization and passage through Start; highly conserved nuclear protein; required for actin cytoskeleton organization; plays a critical role in G1 events; binds Nap1p; involved in 60S ribosome biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003477","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR245C"}


id: YGR246C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03120":null,"YGR246C":null},"has_protein_features":false,"name":"BRF1","ortholog_annotations":[{"gene_uniquename":"YGR246C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03120","reference_uniquename":"PMID:29761456"}],"product":"TFIIIB B-related factor; one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB; mutations in human homolog are associated with autosomal recessive cerebellar-facial-dental syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003478","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR246C"}


id: YGR247W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01428":null,"YGR247W":null},"has_protein_features":false,"name":"CPD1","ortholog_annotations":[{"gene_uniquename":"YGR247W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01428","reference_uniquename":"PMID:29761456"}],"product":"Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003479","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR247W"}


id: YGR248W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01824":null,"YGR248W":null},"has_protein_features":false,"name":"SOL4","ortholog_annotations":[{"gene_uniquename":"YGR248W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01824","reference_uniquename":"PMID:29761456"}],"product":"6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003480","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR248W"}


id: YGR249W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MGA1","product":"Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants","secondary_identifier":"SGD:S000003481","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR249W"}


id: YGR250C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RIE1","product":"RNA binding protein and negative regulator of START; binds mRNA of the G1 cyclin CLN3 to stress granules for translational repression under conditions of stress; recruits the cyclin-dependent protein kinase Cdc28p to stress granules when stressful conditions are relieved, resulting in the dissolution of the granules, and resumption of translation; localizes to stress granules induced by glucose deprivation; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003482","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR250C"}


id: YGR251W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NOP19","product":"Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes","secondary_identifier":"SGD:S000003483","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR251W"}


id: YGR252W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02773":null,"YGR252W":null},"has_protein_features":false,"name":"GCN5","ortholog_annotations":[{"gene_uniquename":"YGR252W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02773","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of ADA and SAGA histone acetyltransferase complexes; modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; relocalizes to the cytosol in response to hypoxia; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003484","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR252W"}


id: YGR253C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05316":null,"YGR253C":null},"has_protein_features":false,"name":"PUP2","ortholog_annotations":[{"gene_uniquename":"YGR253C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05316","reference_uniquename":"PMID:29761456"}],"product":"Alpha 5 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit zeta","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003485","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR253C"}


id: YGR254W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00461":null,"SJAG_02107":null,"SJAG_02369":null,"YGR254W":null},"has_protein_features":false,"name":"ENO1","ortholog_annotations":[{"gene_uniquename":"YGR254W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00461","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR254W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02107","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR254W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02369","reference_uniquename":"PMID:29761456"}],"product":"Enolase I, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression repressed in response to glucose; protein abundance increases in response to DNA replication stress; N-terminally propionylated in vivo; ENO1 has a paralog, ENO2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003486","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR254W"}


id: YGR255C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04000":null,"YGR255C":null},"has_protein_features":false,"name":"COQ6","ortholog_annotations":[{"gene_uniquename":"YGR255C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04000","reference_uniquename":"PMID:29761456"}],"product":"Flavin-dependent monooxygenase involved in ubiquinone biosynthesis; responsible for hydroxylation at position C5 and deamination at C4 during ubiquinone (Coenzyme Q) biosynthesis; localizes to matrix face of mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human homolog COQ6 can complement yeast null mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003487","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR255C"}


id: YGR256W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03852":null,"YGR256W":null},"has_protein_features":false,"name":"GND2","ortholog_annotations":[{"gene_uniquename":"YGR256W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03852","reference_uniquename":"PMID:29761456"}],"product":"6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003488","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR256W"}


id: YGR257C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03577":null,"YGR257C":null},"has_protein_features":false,"name":"MTM1","ortholog_annotations":[{"gene_uniquename":"YGR257C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03577","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein of the mitochondrial carrier family; high affinity pyridoxal 5'-phosphate (PLP) transporter, important for delivery of the PLP cofactor to mitochondrial enzymes; involved in mitochondrial iron homeostasis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003489","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR257C"}


id: YGR258C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02031":null,"YGR258C":null},"has_protein_features":false,"name":"RAD2","ortholog_annotations":[{"gene_uniquename":"YGR258C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02031","reference_uniquename":"PMID:29761456"}],"product":"Single-stranded DNA endonuclease; cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003490","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR258C"}


id: YGR259C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W","secondary_identifier":"SGD:S000003491","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR259C"}


id: YGR260W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04706":null,"YGR260W":null},"has_protein_features":false,"name":"TNA1","ortholog_annotations":[{"gene_uniquename":"YGR260W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04706","reference_uniquename":"PMID:29761456"}],"product":"High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003492","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR260W"}


id: YGR261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02453":null,"YGR261C":null},"has_protein_features":false,"name":"APL6","ortholog_annotations":[{"gene_uniquename":"YGR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02453","reference_uniquename":"PMID:29761456"}],"product":"Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003493","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR261C"}


id: YGR262C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00378":null,"YGR262C":null},"has_protein_features":false,"name":"BUD32","ortholog_annotations":[{"gene_uniquename":"YGR262C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00378","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase; component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; Pyrococcus Bud32 ortholog functions as a P-loop ATPase rather than a protein kinase in the context of the complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; mutation is functionally complemented by human TP53RK","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003494","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR262C"}


id: YGR263C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SAY1","product":"Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; active both in the endoplasmic reticulum (ER) and in lipid droplets; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the ER","secondary_identifier":"SGD:S000003495","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR263C"}


id: YGR264C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01159":null,"YGR264C":null},"has_protein_features":false,"name":"MES1","ortholog_annotations":[{"gene_uniquename":"YGR264C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01159","reference_uniquename":"PMID:29761456"}],"product":"Methionyl-tRNA synthetase; forms a complex with Gus1p, a glutamyl-tRNA synthetase, and Arc1p, which increases the catalytic efficiency of both synthetases; involved in the nuclear export of tRNAs; mutations in human ortholog MARS is associated with pediatric pulmonary alveolar proteinosis, interstitial lung and liver disease, and Charcot-Marie-Tooth disease; human MARS gene can complement the yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003496","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR264C"}


id: YGR265W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase","secondary_identifier":"SGD:S000003497","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR265W"}


id: YGR266W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003498","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR266W"}


id: YGR267C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03275":null,"YGR267C":null},"has_protein_features":false,"name":"FOL2","ortholog_annotations":[{"gene_uniquename":"YGR267C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03275","reference_uniquename":"PMID:29761456"}],"product":"GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis; human homolog GCH1 is implicated in dopa-responsive dystonia (DRD), and can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003499","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR267C"}


id: YGR268C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03273":null,"YGR268C":null},"has_protein_features":false,"name":"HUA1","ortholog_annotations":[{"gene_uniquename":"YGR268C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03273","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic protein containing a zinc finger domain; sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003500","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR268C"}


id: YGR269W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C","secondary_identifier":"SGD:S000003501","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR269W"}


id: YGR270C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YTA7/YGR270W","secondary_identifier":"SGD:S000028641","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR270C-A"}


id: YGR270W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02906":null,"SJAG_04692":null,"YGR270W":null},"has_protein_features":false,"name":"YTA7","ortholog_annotations":[{"gene_uniquename":"YGR270W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02906","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR270W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04692","reference_uniquename":"PMID:29761456"}],"product":"Chromatin-binding ATPase that regulates histone gene expression; only bromodomain-containing AAA-ATPase in yeast; bromodomain interacts with N-terminal tail of histone H3; relocalizes to cytosol in response to hypoxia; human ortholog ANCCA is coactivator of both estrogen and androgen receptors, and increased expression of ANCCA is associated with breast and prostate cancers with poor prognoses","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003502","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR270W"}


id: YGR271C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00562":null,"YGR271C-A":null},"has_protein_features":false,"name":"EFG1","ortholog_annotations":[{"gene_uniquename":"YGR271C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00562","reference_uniquename":"PMID:29761456"}],"product":"Ribosome biogenesis factor required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR271C-A"}


id: YGR271W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00898":null,"YGR271W":null},"has_protein_features":false,"name":"SLH1","ortholog_annotations":[{"gene_uniquename":"YGR271W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00898","reference_uniquename":"PMID:29761456"}],"product":"Subunit of ribosome-associated quality control trigger complex (RQT); putative RNA helicase related to Ski2p; involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses; human homolog is ASCC3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003503","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR271W"}


id: YGR272C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein;YGR272C was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YGR271C-A","secondary_identifier":"SGD:S000003504","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR272C"}


id: YGR273C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01255":null,"SJAG_04659":null,"YGR273C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR273C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01255","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR273C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04659","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; not an essential gene; YGR273C has a paralog, YMR295C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003505","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR273C"}


id: YGR274C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03900":null,"YGR274C":null},"has_protein_features":false,"name":"TAF1","ortholog_annotations":[{"gene_uniquename":"YGR274C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03900","reference_uniquename":"PMID:29761456"}],"product":"TFIID subunit, involved in RNA pol II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003506","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR274C"}


id: YGR275W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RTT102","product":"Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003507","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR275W"}


id: YGR276C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02993":null,"YGR276C":null},"has_protein_features":false,"name":"RNH70","ortholog_annotations":[{"gene_uniquename":"YGR276C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02993","reference_uniquename":"PMID:29761456"}],"product":"3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003508","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR276C"}


id: YGR277C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05277":null,"YGR277C":null},"has_protein_features":false,"name":"CAB4","ortholog_annotations":[{"gene_uniquename":"YGR277C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05277","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; involved in histone acylation; probable pantetheine-phosphate adenylyltransferase (PPAT); PPAT catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT) and by human COASY","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003509","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR277C"}


id: YGR278W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_16453":null,"YGR278W":null},"has_protein_features":false,"name":"CWC22","ortholog_annotations":[{"gene_uniquename":"YGR278W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16453","reference_uniquename":"PMID:29761456"}],"product":"Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003510","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR278W"}


id: YGR279C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SCW4","product":"Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating; SCW4 has a paralog, SCW10, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003511","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR279C"}


id: YGR280C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02758":null,"YGR280C":null},"has_protein_features":false,"name":"PXR1","ortholog_annotations":[{"gene_uniquename":"YGR280C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02758","reference_uniquename":"PMID:29761456"}],"product":"Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003512","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR280C"}


id: YGR281W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01344":null,"SJAG_03785":null,"SJAG_05213":null,"YGR281W":null},"has_protein_features":false,"name":"YOR1","ortholog_annotations":[{"gene_uniquename":"YGR281W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01344","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR281W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03785","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR281W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05213","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter mediates export of many different organic anions including oligomycin; homolog of human cystic fibrosis transmembrane receptor (CFTR)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003513","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR281W"}


id: YGR282C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02192":null,"YGR282C":null},"has_protein_features":false,"name":"BGL2","ortholog_annotations":[{"gene_uniquename":"YGR282C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02192","reference_uniquename":"PMID:29761456"}],"product":"Endo-beta-1,3-glucanase; major protein of the cell wall, involved in cell wall maintenance; involved in incorporation of newly synthesized mannoprotein molecules into the cell wall","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003514","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR282C"}


id: YGR283C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03554":null,"YGR283C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR283C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03554","reference_uniquename":"PMID:29761456"}],"product":"Putative methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus; YGR283C has a paralog, YMR310C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003515","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR283C"}


id: YGR284C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02120":null,"YGR284C":null},"has_protein_features":false,"name":"ERV29","ortholog_annotations":[{"gene_uniquename":"YGR284C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02120","reference_uniquename":"PMID:29761456"}],"product":"Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003516","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR284C"}


id: YGR285C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03094":null,"YGR285C":null},"has_protein_features":false,"name":"ZUO1","ortholog_annotations":[{"gene_uniquename":"YGR285C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03094","reference_uniquename":"PMID:29761456"}],"product":"Ribosome-associated chaperone; zuotin functions in ribosome biogenesis and as a chaperone for nascent polypeptide chains in partnership with Ssz1p and SSb1/2; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p; human gene DNAJC2 can partially complement yeast zuo1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003517","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR285C"}


id: YGR286C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01935":null,"YGR286C":null},"has_protein_features":false,"name":"BIO2","ortholog_annotations":[{"gene_uniquename":"YGR286C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01935","reference_uniquename":"PMID:29761456"}],"product":"Biotin synthase; catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003518","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR286C"}


id: YGR287C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IMA1","product":"Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; member of the IMA isomaltase family","secondary_identifier":"SGD:S000003519","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR287C"}


id: YGR288W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MAL13","product":"MAL-activator protein; part of complex locus MAL1; nonfunctional in genomic reference strain S288C","secondary_identifier":"SGD:S000003520","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR288W"}


id: YGR289C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04905":null,"YGR289C":null},"has_protein_features":false,"name":"MAL11","ortholog_annotations":[{"gene_uniquename":"YGR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"High-affinity maltose transporter (alpha-glucoside transporter); inducible; encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR289C"}


id: YGR290W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)","secondary_identifier":"SGD:S000003522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR290W"}


id: YGR291C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR291C"}


id: YGR292W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MAL12","product":"Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose","secondary_identifier":"SGD:S000003524","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR292W"}


id: YGR293C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR294W","secondary_identifier":"SGD:S000003525","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR293C"}


id: YGR294W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU12","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to both the endoplasmic reticulum and vacuole","secondary_identifier":"SGD:S000003526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR294W"}


id: YGR295C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COS6","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000003527","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR295C"}


id: YGR296C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps TEL07R","secondary_identifier":"SGD:S000028642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR296C-A"}


id: YGR296C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; contained completely within TEL07R","secondary_identifier":"SGD:S000028643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR296C-B"}


id: YGR296W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YRF1-3","product":"Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p","secondary_identifier":"SGD:S000003528","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR296W"}


id: YHL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01364":null,"SJAG_02890":null,"YHL001W":null},"has_protein_features":false,"name":"RPL14B","ortholog_annotations":[{"gene_uniquename":"YHL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01364","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02890","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000993","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL001W"}


id: YHL002C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF HSE1/YHL002W","secondary_identifier":"SGD:S000028770","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL002C-A"}


id: YHL002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00821":null,"YHL002W":null},"has_protein_features":false,"name":"HSE1","ortholog_annotations":[{"gene_uniquename":"YHL002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00821","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000994","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL002W"}


id: YHL003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02085":null,"SJAG_02842":null,"YHL003C":null},"has_protein_features":false,"name":"LAG1","ortholog_annotations":[{"gene_uniquename":"YHL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02085","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02842","reference_uniquename":"PMID:29761456"}],"product":"Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enhances invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000995","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL003C"}


id: YHL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03584":null,"YHL004W":null},"has_protein_features":false,"name":"MRP4","ortholog_annotations":[{"gene_uniquename":"YHL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03584","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000996","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL004W"}


id: YHL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YHL005C is not an essential gene","secondary_identifier":"SGD:S000000997","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL005C"}


id: YHL006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SHU1","product":"Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu2, and promotes error-free DNA repair, mediates inhibition of Srs2p function; essential for promoting the establishment of homolog bias during meiotic homologous recombination; promotes both crossover (CO) and non-crossover (NCO) pathways of meiotic recombination and formation of Rad51p filaments","secondary_identifier":"SGD:S000000998","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL006C"}


id: YHL006W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF STE20/YHL007C","secondary_identifier":"SGD:S000028771","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL006W-A"}


id: YHL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00845":null,"SJAG_02878":null,"YHL007C":null},"has_protein_features":false,"name":"STE20","ortholog_annotations":[{"gene_uniquename":"YHL007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00845","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02878","reference_uniquename":"PMID:26896847"}],"product":"Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000999","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL007C"}


id: YHL008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000001000","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL008C"}


id: YHL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YAP3","product":"Basic leucine zipper (bZIP) transcription factor","secondary_identifier":"SGD:S000001001","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL009C"}


id: YHL010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00509":null,"YHL010C":null},"has_protein_features":false,"name":"ETP1","ortholog_annotations":[{"gene_uniquename":"YHL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00509","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001002","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL010C"}


id: YHL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03811":null,"YHL011C":null},"has_protein_features":false,"name":"PRS3","ortholog_annotations":[{"gene_uniquename":"YHL011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03811","reference_uniquename":"PMID:29761456"}],"product":"5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001003","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL011C"}


id: YHL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01089":null,"SJAG_02178":null,"YHL012W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01089","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02178","reference_uniquename":"PMID:29761456"}],"product":"Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001004","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL012W"}


id: YHL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02774":null,"YHL013C":null},"has_protein_features":false,"name":"OTU2","ortholog_annotations":[{"gene_uniquename":"YHL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02774","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001005","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL013C"}


id: YHL014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04874":null,"YHL014C":null},"has_protein_features":false,"name":"YLF2","ortholog_annotations":[{"gene_uniquename":"YHL014C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04874","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function; has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001006","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL014C"}


id: YHL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04476":null,"YHL015W":null},"has_protein_features":false,"name":"RPS20","ortholog_annotations":[{"gene_uniquename":"YHL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04476","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001007","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL015W"}


id: YHL015W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028828","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL015W-A"}


id: YHL016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02125":null,"YHL016C":null},"has_protein_features":false,"name":"DUR3","ortholog_annotations":[{"gene_uniquename":"YHL016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02125","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane transporter for both urea and polyamines; expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001008","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL016C"}


id: YHL017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02193":null,"SJAG_02823":null,"YHL017W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHL017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02193","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02823","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001009","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL017W"}


id: YHL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MCO14","product":"Putative 4a-hydroxytetrahydrobiopterin dehydratase; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000001010","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL018W"}


id: YHL019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"APM2","product":"Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport","secondary_identifier":"SGD:S000001011","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL019C"}


id: YHL019W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene APM2/YHL019C","secondary_identifier":"SGD:S000028772","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL019W-A"}


id: YHL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OPI1","product":"Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance; null exhibits disrupted mitochondrial metabolism and low cardiolipin content, strongly correlated with overproduction of inositol; binds to phosphatidic acid","secondary_identifier":"SGD:S000001012","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL020C"}


id: YHL021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AIM17","product":"Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss","secondary_identifier":"SGD:S000001013","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL021C"}


id: YHL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05295":null,"YHL022C":null},"has_protein_features":false,"name":"SPO11","ortholog_annotations":[{"gene_uniquename":"YHL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05295","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein required for meiotic recombination; makes DNA double-strand breaks (DSB) during meiotic recombination, homolog pairing, and synaptonemal complex formation; role in meiotic DSB formation involves a topo-II-like transesterase mechanism; forms monotetrameric complex; covalently linked to DSBs through a 5'-phosphodiester bond between a catalytic tyrosine (Y135) and the DSB 5'- end; sequence similarity to a topo VI subunit from archaea, fission yeast rec12 and human SPO11","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001014","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL022C"}


id: YHL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01184":null,"YHL023C":null},"has_protein_features":false,"name":"NPR3","ortholog_annotations":[{"gene_uniquename":"YHL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01184","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of SEAC, a coatomer-related complex that associates dynamically with the vacuole; Npr3p may have a structural or regulatory role, supporting Iml1p function as a GAP for the Rag family GTPase Gtr1p, and leading to inhibition of TORC1 signaling in response to amino acid deprivation; SEACIT is required for non-nitrogen-starvation-induced autophagy; null mutant has meiotic defects; human NPRL3 homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001015","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL023C"}


id: YHL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01919":null,"YHL024W":null},"has_protein_features":false,"name":"RIM4","ortholog_annotations":[{"gene_uniquename":"YHL024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01919","reference_uniquename":"PMID:29761456"}],"product":"Putative RNA-binding protein; involved in regulation of early and middle sporulation genes; forms amyloid-like aggregates under starvation that are active in translational repression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001016","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL024W"}


id: YHL025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNF6","product":"Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions","secondary_identifier":"SGD:S000001017","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL025W"}


id: YHL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02612":null,"YHL026C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02612","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; SWAT-GFP fusion protein localizes to the cell periphery, while mCherry fusion localizes to both the cell periphery and vacuole; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001018","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL026C"}


id: YHL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RIM101","product":"Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC","secondary_identifier":"SGD:S000001019","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL027W"}


id: YHL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02258":null,"YHL028W":null},"has_protein_features":false,"name":"WSC4","ortholog_annotations":[{"gene_uniquename":"YHL028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02258","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum (ER) membrane protein; involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001020","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL028W"}


id: YHL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OCA5","product":"Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts","secondary_identifier":"SGD:S000001021","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL029C"}


id: YHL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00126":null,"YHL030W":null},"has_protein_features":false,"name":"ECM29","ortholog_annotations":[{"gene_uniquename":"YHL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00126","reference_uniquename":"PMID:29761456"}],"product":"Scaffold protein; assists in association of proteasome core particle with regulatory particle; inhibitor of proteasome in vivo and in vitro; inhibits proteasomal ATPase activity; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001022","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL030W"}


id: YHL030W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene GOS1/YHL031C","secondary_identifier":"SGD:S000028773","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL030W-A"}


id: YHL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04739":null,"YHL031C":null},"has_protein_features":false,"name":"GOS1","ortholog_annotations":[{"gene_uniquename":"YHL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04739","reference_uniquename":"PMID:29761456"}],"product":"v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001023","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL031C"}


id: YHL032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GUT1","product":"Glycerol kinase; converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p","secondary_identifier":"SGD:S000001024","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL032C"}


id: YHL033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00537":null,"YHL033C":null},"has_protein_features":false,"name":"RPL8A","ortholog_annotations":[{"gene_uniquename":"YHL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00537","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB during assembly of large subunit; binds Domain I of 25S, 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; RPL8A has paralog RPL8B from whole genome duplication; RPL8A or RPL8B ribosomes not functionally interchangeable; proportions of Rpl8ap, Rpl8bp in 80S ribosome differ in glucose and glycerol; homologous to mammalian ribosomal protein L7A, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001025","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL033C"}


id: YHL034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SBP1","product":"Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; binds to mRNAs under glucose starvation stress, most often in the 5' UTR; found associated with small nucleolar RNAs snR10 and snR11; SBP1 has a paralog, RNP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001026","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL034C"}


id: YHL034W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SBP1/YHL034C","secondary_identifier":"SGD:S000028774","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL034W-A"}


id: YHL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01344":null,"SJAG_03785":null,"SJAG_05213":null,"YHL035C":null},"has_protein_features":false,"name":"VMR1","ortholog_annotations":[{"gene_uniquename":"YHL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01344","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03785","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05213","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane protein; involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; VMR1 has a paralog, YBT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001027","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL035C"}


id: YHL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MUP3","product":"Low affinity methionine permease; similar to Mup1p","secondary_identifier":"SGD:S000001028","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL036W"}


id: YHL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000001029","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL037C"}


id: YHL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CBP2","product":"Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene","secondary_identifier":"SGD:S000001030","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL038C"}


id: YHL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02692":null,"SJAG_03228":null,"YHL039W":null},"has_protein_features":false,"name":"EFM1","ortholog_annotations":[{"gene_uniquename":"YHL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02692","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03228","reference_uniquename":"PMID:29761456"}],"product":"Lysine methyltransferase; involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001031","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL039W"}


id: YHL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YHL040C":null},"has_protein_features":false,"name":"ARN1","ortholog_annotations":[{"gene_uniquename":"YHL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001032","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL040C"}


id: YHL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000001033","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL041W"}


id: YHL042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Endoplasmic reticulum protein; member of DUP380 subfamily of conserved, often subtelomerically-encoded proteins; may contribute to maintenance of ER and nuclear morphology; null mutants have distorted nuclear envelope shape, and discontinuous, misshapen perinuclear ER","secondary_identifier":"SGD:S000001034","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL042W"}


id: YHL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ECM34","product":"Protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; SWAT-GFP, seamless-GFP and mCherry C-terminal fusion proteins localize to the cytosol","secondary_identifier":"SGD:S000001035","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL043W"}


id: YHL044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative integral membrane protein; member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern","secondary_identifier":"SGD:S000001036","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL044W"}


id: YHL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; not an essential gene","secondary_identifier":"SGD:S000001037","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL045W"}


id: YHL046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU13","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","secondary_identifier":"SGD:S000001038","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL046C"}


id: YHL046W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF ARN2/YHL047C","secondary_identifier":"SGD:S000028775","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL046W-A"}


id: YHL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YHL047C":null},"has_protein_features":false,"name":"ARN2","ortholog_annotations":[{"gene_uniquename":"YHL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"Transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001039","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL047C"}


id: YHL048C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028829","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL048C-A"}


id: YHL048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COS8","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000001040","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL048W"}


id: YHL049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001041","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL049C"}


id: YHL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; potential Cdc28p substrate","secondary_identifier":"SGD:S000001042","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL050C"}


id: YHL050W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL050W-A"}


id: YHR001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01590":null,"SJAG_02323":null,"SJAG_02375":null,"SJAG_03718":null,"YHR001W":null},"has_protein_features":false,"name":"OSH7","ortholog_annotations":[{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01590","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02323","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02375","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03718","reference_uniquename":"PMID:29761456"}],"product":"Oxysterol-binding phosphatidylserine transferase; part of family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH7 has a paralog, OSH6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001043","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR001W"}


id: YHR001W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_07006":null,"YHR001W-A":null},"has_protein_features":false,"name":"QCR10","ortholog_annotations":[{"gene_uniquename":"YHR001W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07006","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ubiqunol-cytochrome c oxidoreductase complex; this complex comprises part of the mitochondrial respiratory chain; members include Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003529","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR001W-A"}


id: YHR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03452":null,"YHR002W":null},"has_protein_features":false,"name":"LEU5","ortholog_annotations":[{"gene_uniquename":"YHR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03452","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial carrier protein; involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein SLC25A16, which complements yeast null mutant; does not encode an isozyme of Leu4p, as first hypothesized","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001044","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR002W"}


id: YHR003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02084":null,"YHR003C":null},"has_protein_features":false,"name":"TCD1","ortholog_annotations":[{"gene_uniquename":"YHR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02084","reference_uniquename":"PMID:29761456"}],"product":"tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD1 has a paralog, TCD2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001045","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR003C"}


id: YHR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01906":null,"YHR004C":null},"has_protein_features":false,"name":"NEM1","ortholog_annotations":[{"gene_uniquename":"YHR004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01906","reference_uniquename":"PMID:29761456"}],"product":"Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001046","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR004C"}


id: YHR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02233":null,"SJAG_02444":null,"YHR005C":null},"has_protein_features":false,"name":"GPA1","ortholog_annotations":[{"gene_uniquename":"YHR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02233","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02444","reference_uniquename":"PMID:26896847"}],"product":"Subunit of G protein involved in pheromone response; GTP-binding alpha subunit of heterotrimeric G protein; negatively regulates mating pathway by sequestering G(beta)gamma and triggering an adaptive response; activates Vps34p at endosome; protein abundance increases in response to DNA replication stress; mutations in human homolog GNAS associated with McCune-Albright syndrome","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001047","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR005C"}


id: YHR005C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00687":null,"YHR005C-A":null},"has_protein_features":false,"name":"TIM10","ortholog_annotations":[{"gene_uniquename":"YHR005C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00687","reference_uniquename":"PMID:29761456"}],"product":"Essential protein of the mitochondrial intermembrane space; forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003530","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR005C-A"}


id: YHR006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"STP2","product":"Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001048","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR006W"}


id: YHR007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03750":null,"YHR007C":null},"has_protein_features":false,"name":"ERG11","ortholog_annotations":[{"gene_uniquename":"YHR007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03750","reference_uniquename":"PMID:29761456"}],"product":"Lanosterol 14-alpha-demethylase; catalyzes C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in ergosterol biosynthesis pathway; transcriptionally down-regulated when ergosterol is in excess; member of cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; human CYP51A1 functionally complements the lethality of the erg11 null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001049","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR007C"}


id: YHR007C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry; SWAT-GFP fusion protein localizes to the nucleus","secondary_identifier":"SGD:S000028830","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR007C-A"}


id: YHR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03303":null,"YHR008C":null},"has_protein_features":false,"name":"SOD2","ortholog_annotations":[{"gene_uniquename":"YHR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03303","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity and oxidative stress; human mitochondrial SOD2 can complement a yeast null mutant and human cytoplasmic SOD1 can also complement when targeted to the mitochondrial matrix","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001050","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR008C"}


id: YHR009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00287":null,"SJAG_04359":null,"YHR009C":null},"has_protein_features":false,"name":"TDA3","ortholog_annotations":[{"gene_uniquename":"YHR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00287","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04359","reference_uniquename":"PMID:29761456"}],"product":"Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001051","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR009C"}


id: YHR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01588":null,"SJAG_02802":null,"YHR010W":null},"has_protein_features":false,"name":"RPL27A","ortholog_annotations":[{"gene_uniquename":"YHR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01588","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02802","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001052","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR010W"}


id: YHR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02977":null,"YHR011W":null},"has_protein_features":false,"name":"DIA4","ortholog_annotations":[{"gene_uniquename":"YHR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02977","reference_uniquename":"PMID:29761456"}],"product":"Probable mitochondrial seryl-tRNA synthetase; mutant displays increased invasive and pseudohyphal growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001053","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR011W"}


id: YHR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04629":null,"YHR012W":null},"has_protein_features":false,"name":"VPS29","ortholog_annotations":[{"gene_uniquename":"YHR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04629","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the membrane-associated retromer complex; endosomal protein; essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001054","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR012W"}


id: YHR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04631":null,"YHR013C":null},"has_protein_features":false,"name":"ARD1","ortholog_annotations":[{"gene_uniquename":"YHR013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04631","reference_uniquename":"PMID:29761456"}],"product":"Subunit of protein N-terminal acetyltransferase NatA; NatA comprises Nat1p, Ard1p, Nat5p; acetylates many proteins to influence telomeric silencing, cell cycle, heat-shock resistance, mating, sporulation, early stages of mitophagy; protein abundance increases under DNA replication stress; mutations in human homolog X-linked NAA10 lead to Ogden syndrome (S37P) and intellectual disability (R116W); expression of human NAA10 and NAA15 can complement ard1 nat1 double mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001055","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR013C"}


id: YHR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPO13","product":"Meiotic regulator; involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II; anaphase-promoting complex (APC) substrate that is degraded during anaphase I; expressed only in meiotic cells","secondary_identifier":"SGD:S000001056","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR014W"}


id: YHR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MIP6","product":"Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001057","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR015W"}


id: YHR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00970":null,"YHR016C":null},"has_protein_features":false,"name":"YSC84","ortholog_annotations":[{"gene_uniquename":"YHR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00970","reference_uniquename":"PMID:29761456"}],"product":"Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001058","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR016C"}


id: YHR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04124":null,"YHR017W":null},"has_protein_features":false,"name":"YSC83","ortholog_annotations":[{"gene_uniquename":"YHR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04124","reference_uniquename":"PMID:29761456"}],"product":"Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001059","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR017W"}


id: YHR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01461":null,"YHR018C":null},"has_protein_features":false,"name":"ARG4","ortholog_annotations":[{"gene_uniquename":"YHR018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01461","reference_uniquename":"PMID:29761456"}],"product":"Argininosuccinate lyase; catalyzes the final step in the arginine biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001060","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR018C"}


id: YHR019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02517":null,"YHR019C":null},"has_protein_features":false,"name":"DED81","ortholog_annotations":[{"gene_uniquename":"YHR019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02517","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic asparaginyl-tRNA synthetase; required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001061","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR019C"}


id: YHR020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01259":null,"YHR020W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHR020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01259","reference_uniquename":"PMID:29761456"}],"product":"Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001062","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR020W"}


id: YHR021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02340":null,"YHR021C":null},"has_protein_features":false,"name":"RPS27B","ortholog_annotations":[{"gene_uniquename":"YHR021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02340","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001063","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR021C"}


id: YHR021W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ECM12","product":"Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity","secondary_identifier":"SGD:S000003531","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR021W-A"}


id: YHR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YHR022C is not an essential gene","secondary_identifier":"SGD:S000001064","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR022C"}


id: YHR022C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR022C-A"}


id: YHR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02431":null,"SJAG_03703":null,"YHR023W":null},"has_protein_features":false,"name":"MYO1","ortholog_annotations":[{"gene_uniquename":"YHR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02431","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03703","reference_uniquename":"PMID:29761456"}],"product":"Type II myosin heavy chain; required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001065","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR023W"}


id: YHR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04641":null,"YHR024C":null},"has_protein_features":false,"name":"MAS2","ortholog_annotations":[{"gene_uniquename":"YHR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04641","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001066","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR024C"}


id: YHR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03141":null,"YHR025W":null},"has_protein_features":false,"name":"THR1","ortholog_annotations":[{"gene_uniquename":"YHR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03141","reference_uniquename":"PMID:29761456"}],"product":"Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulated by the GCN4-mediated general amino acid control pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001067","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR025W"}


id: YHR026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02023":null,"YHR026W":null},"has_protein_features":false,"name":"VMA16","ortholog_annotations":[{"gene_uniquename":"YHR026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02023","reference_uniquename":"PMID:29761456"}],"product":"Subunit c'' of the vacuolar ATPase; v-ATPase functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001068","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR026W"}


id: YHR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03638":null,"YHR027C":null},"has_protein_features":false,"name":"RPN1","ortholog_annotations":[{"gene_uniquename":"YHR027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03638","reference_uniquename":"PMID:29761456"}],"product":"Non-ATPase base subunit of the 19S RP of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions; RP is the acronym for regulatory particle","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001069","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR027C"}


id: YHR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02565":null,"YHR028C":null},"has_protein_features":false,"name":"DAP2","ortholog_annotations":[{"gene_uniquename":"YHR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02565","reference_uniquename":"PMID:29761456"}],"product":"Dipeptidyl aminopeptidase; synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001070","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR028C"}


id: YHR028W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF DAP2/YHR028C","secondary_identifier":"SGD:S000028776","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR028W-A"}


id: YHR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YHI9","product":"Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production","secondary_identifier":"SGD:S000001071","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR029C"}


id: YHR030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04551":null,"YHR030C":null},"has_protein_features":false,"name":"SLT2","ortholog_annotations":[{"gene_uniquename":"YHR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04551","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine MAP kinase; coordinates expression of all 19S regulatory particle assembly-chaperones (RACs) to control proteasome abundance; involved in regulating maintenance of cell wall integrity, cell cycle progression, nuclear mRNA retention in heat shock, septum assembly; required for mitophagy, pexophagy; affects recruitment of mitochondria to phagophore assembly site; plays role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001072","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR030C"}


id: YHR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03780":null,"YHR031C":null},"has_protein_features":false,"name":"RRM3","ortholog_annotations":[{"gene_uniquename":"YHR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03780","reference_uniquename":"PMID:29761456"}],"product":"DNA helicase involved in rDNA replication and Ty1 transposition; binds to and suppresses DNA damage at G4 motifs in vivo; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001073","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR031C"}


id: YHR032C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032W-A","secondary_identifier":"SGD:S000028646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR032C-A"}


id: YHR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01145":null,"SJAG_03951":null,"YHR032W":null},"has_protein_features":false,"name":"ERC1","ortholog_annotations":[{"gene_uniquename":"YHR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01145","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03951","reference_uniquename":"PMID:29761456"}],"product":"Member of the multi-drug and toxin extrusion (MATE) family; the MATE family is part of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001074","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR032W"}


id: YHR032W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A","secondary_identifier":"SGD:S000028831","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR032W-A"}


id: YHR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03457":null,"YHR033W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03457","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001075","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR033W"}


id: YHR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PIH1","product":"Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II","secondary_identifier":"SGD:S000001076","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR034C"}


id: YHR035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NEL1","product":"Activator of Sar1p GTPase activity; paralog of Sec23 but does not associate with the COPII components; not an essential gene","secondary_identifier":"SGD:S000001077","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR035W"}


id: YHR036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01422":null,"YHR036W":null},"has_protein_features":false,"name":"BRL1","ortholog_annotations":[{"gene_uniquename":"YHR036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01422","reference_uniquename":"PMID:29761456"}],"product":"Essential nuclear envelope/ER integral membrane protein; interacts and functions with Apq12p and Brr6p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, mRNA nuclear export and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; identified as a dosage suppressor of a temperature sensitive mutation in the major karyopherin, CRM1; homologous to Brr6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001078","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR036W"}


id: YHR037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02235":null,"YHR037W":null},"has_protein_features":false,"name":"PUT2","ortholog_annotations":[{"gene_uniquename":"YHR037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02235","reference_uniquename":"PMID:29761456"}],"product":"Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of human homolog ALDH4A1 causes type II hyperprolinemia (HPII), an autosomal recessive inborn error of metabolism; human homolog ALDH4A1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001079","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR037W"}


id: YHR038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03232":null,"YHR038W":null},"has_protein_features":false,"name":"RRF1","ortholog_annotations":[{"gene_uniquename":"YHR038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03232","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosome recycling factor; essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001080","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR038W"}


id: YHR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00482":null,"YHR039C":null},"has_protein_features":false,"name":"MSC7","ortholog_annotations":[{"gene_uniquename":"YHR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00482","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001081","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR039C"}


id: YHR039C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01447":null,"YHR039C-A":null},"has_protein_features":false,"name":"VMA10","ortholog_annotations":[{"gene_uniquename":"YHR039C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01447","reference_uniquename":"PMID:29761456"}],"product":"Subunit G of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002100","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR039C-A"}


id: YHR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00752":null,"YHR040W":null},"has_protein_features":false,"name":"BCD1","ortholog_annotations":[{"gene_uniquename":"YHR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00752","reference_uniquename":"PMID:29761456"}],"product":"Essential protein required for the accumulation of box C/D snoRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001082","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR040W"}


id: YHR041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04099":null,"YHR041C":null},"has_protein_features":false,"name":"SRB2","ortholog_annotations":[{"gene_uniquename":"YHR041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04099","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001083","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR041C"}


id: YHR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04270":null,"YHR042W":null},"has_protein_features":false,"name":"NCP1","ortholog_annotations":[{"gene_uniquename":"YHR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04270","reference_uniquename":"PMID:29761456"}],"product":"NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001084","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR042W"}


id: YHR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DOG2","product":"2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed; DOG2 has a paralog, DOG1, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae","secondary_identifier":"SGD:S000001085","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR043C"}


id: YHR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DOG1","product":"2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed; DOG1 has a paralog, DOG2, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae","secondary_identifier":"SGD:S000001086","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR044C"}


id: YHR045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum","secondary_identifier":"SGD:S000001087","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR045W"}


id: YHR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"INM1","product":"Inositol monophosphatase; involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate","secondary_identifier":"SGD:S000001088","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR046C"}


id: YHR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00181":null,"YHR047C":null},"has_protein_features":false,"name":"AAP1","ortholog_annotations":[{"gene_uniquename":"YHR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00181","reference_uniquename":"PMID:29761456"}],"product":"Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001089","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR047C"}


id: YHR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02344":null,"YHR048W":null},"has_protein_features":false,"name":"YHK8","ortholog_annotations":[{"gene_uniquename":"YHR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02344","reference_uniquename":"PMID:26896847"}],"product":"Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001090","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR048W"}


id: YHR049C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003532","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR049C-A"}


id: YHR049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03760":null,"YHR049W":null},"has_protein_features":false,"name":"FSH1","ortholog_annotations":[{"gene_uniquename":"YHR049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03760","reference_uniquename":"PMID:26896847"}],"product":"Lysophospholipase; hydrolyzes lysophosphatidylserine to release free fatty acid; involved in regulated cell death; localizes to both the nucleus and cytoplasm; contains a catalytic triad of Ser-His-Asp that is part of an alpha/beta hydrolase fold and a lipase motif (GXSXG); sequence similarity to Fsh2p and Fsh3p and the human candidate tumor suppressor and serine hydrolase, OVCA2","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001091","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR049W"}


id: YHR050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01007":null,"YHR050W":null},"has_protein_features":false,"name":"SMF2","ortholog_annotations":[{"gene_uniquename":"YHR050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01007","reference_uniquename":"PMID:29761456"}],"product":"Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001092","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR050W"}


id: YHR050W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028832","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR050W-A"}


id: YHR051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01355":null,"YHR051W":null},"has_protein_features":false,"name":"COX6","ortholog_annotations":[{"gene_uniquename":"YHR051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01355","reference_uniquename":"PMID:29761456"}],"product":"Subunit VI of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001093","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR051W"}


id: YHR052C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Novel ORF identified by enrichment-based proteomics","secondary_identifier":"SGD:S000303807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR052C-B"}


id: YHR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01420":null,"SJAG_01752":null,"YHR052W":null},"has_protein_features":false,"name":"CIC1","ortholog_annotations":[{"gene_uniquename":"YHR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01420","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01752","reference_uniquename":"PMID:29761456"}],"product":"Essential protein that interacts with proteasome components; has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001094","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR052W"}


id: YHR052W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps CUP1-1","secondary_identifier":"SGD:S000028647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR052W-A"}


id: YHR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CUP1-1","product":"Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-1 has a paralog, CUP1-2, that arose from a segmental duplication","secondary_identifier":"SGD:S000001095","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR053C"}


id: YHR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; partial duplicate of RSC30/YHR056C, truncated remnant of segmental duplication","secondary_identifier":"SGD:S000001096","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR054C"}


id: YHR054C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Novel ORF identified by enrichment-based proteomics","secondary_identifier":"SGD:S000303808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR054C-B"}


id: YHR054W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps CUP1-2","secondary_identifier":"SGD:S000028648","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR054W-A"}


id: YHR055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CUP1-2","product":"Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-2 has a paralog, CUP1-1, that arose from a segmental duplication","secondary_identifier":"SGD:S000001097","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR055C"}


id: YHR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RSC30","product":"Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; null mutants are osmosensitive; RSC30 has a paralog, RSC3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001098","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR056C"}


id: YHR056W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps ORF RSC30/YHR056C","secondary_identifier":"SGD:S000028777","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR056W-A"}


id: YHR057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02413":null,"YHR057C":null},"has_protein_features":false,"name":"CPR2","ortholog_annotations":[{"gene_uniquename":"YHR057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02413","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; seamless-GFP and mCherry fusion proteins localize to the vacuole, while SWAT-GFP fusion localizes to both the endoplasmic reticulum and vacuole; suppresses toxicity of slow-folding human Z-type alpha1-antitrypsin variant associated with liver cirrhosis and emphysema","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001099","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR057C"}


id: YHR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04705":null,"YHR058C":null},"has_protein_features":false,"name":"MED6","ortholog_annotations":[{"gene_uniquename":"YHR058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04705","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001100","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR058C"}


id: YHR059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00060":null,"YHR059W":null},"has_protein_features":false,"name":"FYV4","ortholog_annotations":[{"gene_uniquename":"YHR059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00060","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; required for survival upon exposure to K1 killer toxin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001101","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR059W"}


id: YHR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"VMA22","product":"Protein that is required for vacuolar H+-ATPase (V-ATPase) function; peripheral membrane protein; not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)","secondary_identifier":"SGD:S000001102","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR060W"}


id: YHR061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GIC1","product":"Rho-family GTPase interacting protein and Cdc42p effector; required with Gic2p for polarity establishment and initiation of budding; involved in recruitment of septins to the presumptive bud site; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; gic1 gic2 double mutants are defective for polarizing Cdc42p at elevated temperature, so may function both up- and downstream of Cdc42p; regulates mitotic exit; relocalizes from bud neck to nucleus upon DNA replication stress","secondary_identifier":"SGD:S000001103","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR061C"}


id: YHR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04916":null,"YHR062C":null},"has_protein_features":false,"name":"RPP1","ortholog_annotations":[{"gene_uniquename":"YHR062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04916","reference_uniquename":"PMID:29761456"}],"product":"Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001104","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR062C"}


id: YHR063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAN5","product":"2-dehydropantoate 2-reductase; part of the pantothenic acid pathway, structurally homologous to E. coli panE","secondary_identifier":"SGD:S000001105","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR063C"}


id: YHR063W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF SSZ1/YHR064C","secondary_identifier":"SGD:S000028778","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR063W-A"}


id: YHR064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01510":null,"YHR064C":null},"has_protein_features":false,"name":"SSZ1","ortholog_annotations":[{"gene_uniquename":"YHR064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01510","reference_uniquename":"PMID:29761456"}],"product":"Hsp70 protein that interacts with Zuo1p (a DnaJ homolog); interacts with Zuo1p to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001106","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR064C"}


id: YHR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04974":null,"YHR065C":null},"has_protein_features":false,"name":"RRP3","ortholog_annotations":[{"gene_uniquename":"YHR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04974","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001107","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR065C"}


id: YHR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02427":null,"YHR066W":null},"has_protein_features":false,"name":"SSF1","ortholog_annotations":[{"gene_uniquename":"YHR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02427","reference_uniquename":"PMID:29761456"}],"product":"Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001108","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR066W"}


id: YHR067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00305":null,"YHR067W":null},"has_protein_features":false,"name":"HTD2","ortholog_annotations":[{"gene_uniquename":"YHR067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00305","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial 3-hydroxyacyl-thioester dehydratase; involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001109","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR067W"}


id: YHR068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04130":null,"YHR068W":null},"has_protein_features":false,"name":"DYS1","ortholog_annotations":[{"gene_uniquename":"YHR068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04130","reference_uniquename":"PMID:29761456"}],"product":"Deoxyhypusine synthase; catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric; human homolog DHPS allows growth of yeast haploid dys1 null mutant after sporulation of heterozygous diploid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001110","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR068W"}


id: YHR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01521":null,"YHR069C":null},"has_protein_features":false,"name":"RRP4","ortholog_annotations":[{"gene_uniquename":"YHR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01521","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; mutations in the human ortholog, EXOSC2, cause SHRF (Short stature, Hearing loss, Retinitis pigmentosa and distinctive Facies) syndrome, an RNA exosomopathy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001111","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR069C"}


id: YHR069C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps ORF TRM5/YHR070W","secondary_identifier":"SGD:S000028779","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR069C-A"}


id: YHR070C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W","secondary_identifier":"SGD:S000028780","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR070C-A"}


id: YHR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00255":null,"YHR070W":null},"has_protein_features":false,"name":"TRM5","ortholog_annotations":[{"gene_uniquename":"YHR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00255","reference_uniquename":"PMID:29761456"}],"product":"tRNA(m(1)G37)methyltransferase; methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; localized to both cytoplasm and mitochondria, and modifies both cytoplasmic and mitochondrial tRNAs; mutations in human ortholog TRMT5 are associated with skeletal muscle respiratory chain deficiencies, and trm5 mutations analogous to disease mutations decrease respiration","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001112","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR070W"}


id: YHR071C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ERG7/YHR072W","secondary_identifier":"SGD:S000028781","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR071C-A"}


id: YHR071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03591":null,"YHR071W":null},"has_protein_features":false,"name":"PCL5","ortholog_annotations":[{"gene_uniquename":"YHR071W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03591","reference_uniquename":"PMID:29761456"}],"product":"Cyclin; interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001113","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR071W"}


id: YHR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00624":null,"YHR072W":null},"has_protein_features":false,"name":"ERG7","ortholog_annotations":[{"gene_uniquename":"YHR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00624","reference_uniquename":"PMID:29761456"}],"product":"Lanosterol synthase; an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis; human LSS functionally complements the lethality of the erg7 null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001114","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR072W"}


id: YHR072W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00566":null,"YHR072W-A":null},"has_protein_features":false,"name":"NOP10","ortholog_annotations":[{"gene_uniquename":"YHR072W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00566","reference_uniquename":"PMID:29761456"}],"product":"Subunit of box H/ACA snoRNP complex; required for pseudouridylation and processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR072W-A"}


id: YHR073C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028833","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR073C-B"}


id: YHR073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00355":null,"YHR073W":null},"has_protein_features":false,"name":"OSH3","ortholog_annotations":[{"gene_uniquename":"YHR073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00355","reference_uniquename":"PMID:29761456"}],"product":"Member of an oxysterol-binding protein family; this family has seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane; regulated by sterol binding","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001115","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR073W"}


id: YHR073W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028834","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR073W-A"}


id: YHR074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02618":null,"YHR074W":null},"has_protein_features":false,"name":"QNS1","ortholog_annotations":[{"gene_uniquename":"YHR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02618","reference_uniquename":"PMID:29761456"}],"product":"Glutamine-dependent NAD(+) synthetase; essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001116","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR074W"}


id: YHR075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01628":null,"YHR075C":null},"has_protein_features":false,"name":"PPE1","ortholog_annotations":[{"gene_uniquename":"YHR075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01628","reference_uniquename":"PMID:29761456"}],"product":"Protein with carboxyl methyl esterase activity; may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001117","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR075C"}


id: YHR076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01672":null,"YHR076W":null},"has_protein_features":false,"name":"PTC7","ortholog_annotations":[{"gene_uniquename":"YHR076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01672","reference_uniquename":"PMID:29761456"}],"product":"Type 2C serine/threonine protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope; activates coenzyme Q6 biosynthesis by dephosphorylation of demethoxy-Q6 hydroxylase Coq7p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001118","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR076W"}


id: YHR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05014":null,"YHR077C":null},"has_protein_features":false,"name":"NMD2","ortholog_annotations":[{"gene_uniquename":"YHR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05014","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001119","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR077C"}


id: YHR078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"High osmolarity-regulated gene of unknown function","secondary_identifier":"SGD:S000001120","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR078W"}


id: YHR079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04435":null,"YHR079C":null},"has_protein_features":false,"name":"IRE1","ortholog_annotations":[{"gene_uniquename":"YHR079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04435","reference_uniquename":"PMID:29761456"}],"product":"Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001121","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR079C"}


id: YHR079C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03221":null,"YHR079C-A":null},"has_protein_features":false,"name":"SAE3","ortholog_annotations":[{"gene_uniquename":"YHR079C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03221","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001957","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR079C-A"}


id: YHR080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01329":null,"YHR080C":null},"has_protein_features":false,"name":"LAM4","ortholog_annotations":[{"gene_uniquename":"YHR080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01329","reference_uniquename":"PMID:29761456"}],"product":"Sterol-binding protein that localizes to puncta in the cortical ER; sterol binding occurs via two StART-like domains; one of six StART-like domain-containing proteins in yeast that may be involved in intracellular sterol transfer between membranes; conserved across eukaryotes; has both GRAM and StART-like (VASt) domains; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001122","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR080C"}


id: YHR081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01191":null,"YHR081W":null},"has_protein_features":false,"name":"LRP1","ortholog_annotations":[{"gene_uniquename":"YHR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01191","reference_uniquename":"PMID:29761456"}],"product":"Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; forms a stable heterodimer with Rrp6p and regulates its exonucleolytic activity; rapidly degraded by the proteasome in the absence of Rrp6p; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001123","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR081W"}


id: YHR082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03529":null,"YHR082C":null},"has_protein_features":false,"name":"KSP1","ortholog_annotations":[{"gene_uniquename":"YHR082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03529","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001124","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR082C"}


id: YHR083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01780":null,"YHR083W":null},"has_protein_features":false,"name":"SAM35","ortholog_annotations":[{"gene_uniquename":"YHR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01780","reference_uniquename":"PMID:29761456"}],"product":"Component of the sorting and assembly machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001125","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR083W"}


id: YHR084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"STE12","product":"Transcription factor that is activated by a MAPK signaling cascade; activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth","secondary_identifier":"SGD:S000001126","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR084W"}


id: YHR085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04252":null,"YHR085W":null},"has_protein_features":false,"name":"IPI1","ortholog_annotations":[{"gene_uniquename":"YHR085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04252","reference_uniquename":"PMID:29761456"}],"product":"Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001127","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR085W"}


id: YHR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00474":null,"SJAG_02573":null,"YHR086W":null},"has_protein_features":false,"name":"NAM8","ortholog_annotations":[{"gene_uniquename":"YHR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00474","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02573","reference_uniquename":"PMID:26896847"}],"product":"RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001128","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR086W"}


id: YHR086W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","secondary_identifier":"SGD:S000028552","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR086W-A"}


id: YHR087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00487":null,"YHR087W":null},"has_protein_features":false,"name":"RTC3","ortholog_annotations":[{"gene_uniquename":"YHR087W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00487","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog is SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001129","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR087W"}


