# genes

id: YDR218C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01769":null,"YDR218C":null},"has_protein_features":false,"name":"SPR28","ortholog_annotations":[{"gene_uniquename":"YDR218C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01769","reference_uniquename":"PMID:26896847"}],"product":"Sporulation-specific homolog of the CDC3/10/11/12 family of genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation; the yeast CDC3/10/11/12 family is a family of bud neck microfilament genes","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000002626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR218C"}


id: YDR219C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MFB1","product":"Mitochondria-associated F-box protein; involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding","secondary_identifier":"SGD:S000002627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR219C"}


id: YDR220C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant exhibits synthetic phenotype with alpha-synuclein","secondary_identifier":"SGD:S000002628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR220C"}


id: YDR221W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03535":null,"YDR221W":null},"has_protein_features":false,"name":"GTB1","ortholog_annotations":[{"gene_uniquename":"YDR221W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03535","reference_uniquename":"PMID:29761456"}],"product":"Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR221W"}


id: YDR222W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YDR222W has a paralog, YLR225C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR222W"}


id: YDR223W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02671":null,"YDR223W":null},"has_protein_features":false,"name":"CRF1","ortholog_annotations":[{"gene_uniquename":"YDR223W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02671","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional corepressor; involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain; CRF1 has a paralog, IFH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR223W"}


id: YDR224C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03941":null,"YDR224C":null},"has_protein_features":false,"name":"HTB1","ortholog_annotations":[{"gene_uniquename":"YDR224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03941","reference_uniquename":"PMID:29761456"}],"product":"Histone H2B; core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates reassembly after DNA replication, transcriptional activation, meiotic DSB formation and H3 methylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR224C"}


id: YDR225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01873":null,"SJAG_03942":null,"YDR225W":null},"has_protein_features":false,"name":"HTA1","ortholog_annotations":[{"gene_uniquename":"YDR225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01873","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03942","reference_uniquename":"PMID:29761456"}],"product":"Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; N-terminally propionylated in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002633","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR225W"}


id: YDR226W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02038":null,"YDR226W":null},"has_protein_features":false,"name":"ADK1","ortholog_annotations":[{"gene_uniquename":"YDR226W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02038","reference_uniquename":"PMID:29761456"}],"product":"Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress; mutations affecting Adk1p catalytic activity deregulate expression of phosphate utilization genes PHO5 and PHO84; human homolog AK1 can complement yeast adk1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002634","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR226W"}


id: YDR227W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SIR4","product":"SIR protein involved in assembly of silent chromatin domains; silent information regulator (SIR) along with SIR2 and SIR3; involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; some SIR4 alleles prolong lifespan; required for Ku-mediated telomerase recruitment, telomere lengthening, and telomere hypercluster formation in quiescent yeast cells","secondary_identifier":"SGD:S000002635","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR227W"}


id: YDR228C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02037":null,"YDR228C":null},"has_protein_features":false,"name":"PCF11","ortholog_annotations":[{"gene_uniquename":"YDR228C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02037","reference_uniquename":"PMID:29761456"}],"product":"mRNA 3' end processing factor; essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002636","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR228C"}


id: YDR229W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IVY1","product":"Phospholipid-binding protein that interacts with both Ypt7p and Vps33p; may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase; contains a putative inverse BAR (I-BAR) domain that can mold lipid bilayer membranes into protrusions","secondary_identifier":"SGD:S000002637","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR229W"}


id: YDR230W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20/YDR231C","secondary_identifier":"SGD:S000002638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR230W"}


id: YDR231C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06046":null,"YDR231C":null},"has_protein_features":false,"name":"COX20","ortholog_annotations":[{"gene_uniquename":"YDR231C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06046","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein; required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002639","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR231C"}


id: YDR232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03961":null,"YDR232W":null},"has_protein_features":false,"name":"HEM1","ortholog_annotations":[{"gene_uniquename":"YDR232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03961","reference_uniquename":"PMID:29761456"}],"product":"5-aminolevulinate synthase; catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p; has a pyridoxal phosphate cofactor whose insertion is mediated by Mcx1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002640","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR232W"}


id: YDR233C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01848":null,"YDR233C":null},"has_protein_features":false,"name":"RTN1","ortholog_annotations":[{"gene_uniquename":"YDR233C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01848","reference_uniquename":"PMID:29761456"}],"product":"Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; increases tubular ER when overexpressed; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; member of the RTNLA subfamily","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002641","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR233C"}


id: YDR234W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01574":null,"YDR234W":null},"has_protein_features":false,"name":"LYS4","ortholog_annotations":[{"gene_uniquename":"YDR234W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01574","reference_uniquename":"PMID:29761456"}],"product":"Homoaconitase; catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR234W"}


id: YDR235W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00058":null,"YDR235W":null},"has_protein_features":false,"name":"PRP42","ortholog_annotations":[{"gene_uniquename":"YDR235W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00058","reference_uniquename":"PMID:29761456"}],"product":"U1 snRNP protein involved in splicing; required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR235W"}


id: YDR236C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04845":null,"YDR236C":null},"has_protein_features":false,"name":"FMN1","ortholog_annotations":[{"gene_uniquename":"YDR236C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04845","reference_uniquename":"PMID:29761456"}],"product":"Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane; human RFK functionally complements the lethality of the null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR236C"}


id: YDR237W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01719":null,"YDR237W":null},"has_protein_features":false,"name":"MRPL7","ortholog_annotations":[{"gene_uniquename":"YDR237W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01719","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR237W"}


id: YDR238C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04002":null,"YDR238C":null},"has_protein_features":false,"name":"SEC26","ortholog_annotations":[{"gene_uniquename":"YDR238C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04002","reference_uniquename":"PMID:29761456"}],"product":"Essential beta-coat protein of the COPI coatomer; involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR238C"}


id: YDR239C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments","secondary_identifier":"SGD:S000002647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR239C"}


id: YDR240C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNU56","product":"Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex","secondary_identifier":"SGD:S000002648","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR240C"}


id: YDR241W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BUD26","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay","secondary_identifier":"SGD:S000002649","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR241W"}


id: YDR242W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AMD2","product":"Putative amidase","secondary_identifier":"SGD:S000002650","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR242W"}


id: YDR243C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04230":null,"YDR243C":null},"has_protein_features":false,"name":"PRP28","ortholog_annotations":[{"gene_uniquename":"YDR243C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04230","reference_uniquename":"PMID:29761456"}],"product":"Pre-mRNA splicing factor; RNA binding protein involved in RNA isomerization at the 5' splice site and for exchange of U6 for U1 snRNA at the 5' splice site; similar to the RNA helicases of the DEAD-box family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR243C"}


id: YDR244W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00702":null,"YDR244W":null},"has_protein_features":false,"name":"PEX5","ortholog_annotations":[{"gene_uniquename":"YDR244W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00702","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal membrane signal receptor for peroxisomal matrix proteins; receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins; required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR244W"}


id: YDR245W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01972":null,"SJAG_02996":null,"SJAG_03555":null,"SJAG_03790":null,"SJAG_03871":null,"SJAG_04095":null,"SJAG_04401":null,"YDR245W":null},"has_protein_features":false,"name":"MNN10","ortholog_annotations":[{"gene_uniquename":"YDR245W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01972","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR245W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02996","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR245W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03555","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR245W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03790","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR245W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03871","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR245W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04095","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR245W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04401","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a Golgi mannosyltransferase complex; complex mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family; other members of the complex are Anp1p, Mnn9p, Mnn11p, and Hoc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002653","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR245W"}


id: YDR246W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04021":null,"YDR246W":null},"has_protein_features":false,"name":"TRS23","ortholog_annotations":[{"gene_uniquename":"YDR246W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04021","reference_uniquename":"PMID:29761456"}],"product":"Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); human homolog is TRAPPC4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002654","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR246W"}


id: YDR246W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028542","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR246W-A"}


id: YDR247W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01311":null,"YDR247W":null},"has_protein_features":false,"name":"VHS1","ortholog_annotations":[{"gene_uniquename":"YDR247W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01311","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; VHS1 has a paralog, SKS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR247W"}


id: YDR248C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00633":null,"YDR248C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR248C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00633","reference_uniquename":"PMID:29761456"}],"product":"Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR248C"}


id: YDR249C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000002657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR249C"}


id: YDR250C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR250C"}


id: YDR251W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02729":null,"SJAG_04591":null,"YDR251W":null},"has_protein_features":false,"name":"PAM1","ortholog_annotations":[{"gene_uniquename":"YDR251W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02729","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR251W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04591","reference_uniquename":"PMID:29761456"}],"product":"Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype; PAM1 has a paralog, SVL3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR251W"}


id: YDR252W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01733":null,"YDR252W":null},"has_protein_features":false,"name":"BTT1","ortholog_annotations":[{"gene_uniquename":"YDR252W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01733","reference_uniquename":"PMID:29761456"}],"product":"Heterotrimeric nascent polypeptide-associated complex beta3 subunit; complex binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3; BTT1 has a paralog, EGD1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR252W"}


id: YDR253C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MET32","product":"Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; feedforward loop exists in the regulation of genes controlled by Met4p and Met32p; lack of such a loop for MET31 may account for the differential actions of Met32p and Met31p; MET32 has a paralog, MET31, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR253C"}


id: YDR254W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04696":null,"YDR254W":null},"has_protein_features":false,"name":"CHL4","ortholog_annotations":[{"gene_uniquename":"YDR254W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04696","reference_uniquename":"PMID:29761456"}],"product":"Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; forms a stable complex with Iml3p; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, and Mif2p; required for the spindle assembly checkpoint; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR254W"}


id: YDR255C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01637":null,"YDR255C":null},"has_protein_features":false,"name":"RMD5","ortholog_annotations":[{"gene_uniquename":"YDR255C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01637","reference_uniquename":"PMID:29761456"}],"product":"Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002663","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR255C"}


id: YDR256C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04823":null,"YDR256C":null},"has_protein_features":false,"name":"CTA1","ortholog_annotations":[{"gene_uniquename":"YDR256C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04823","reference_uniquename":"PMID:29761456"}],"product":"Catalase A; breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002664","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR256C"}


id: YDR257C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01482":null,"SJAG_03869":null,"YDR257C":null},"has_protein_features":false,"name":"RKM4","ortholog_annotations":[{"gene_uniquename":"YDR257C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01482","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR257C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03869","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002665","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR257C"}


id: YDR258C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02825":null,"YDR258C":null},"has_protein_features":false,"name":"HSP78","ortholog_annotations":[{"gene_uniquename":"YDR258C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02825","reference_uniquename":"PMID:29761456"}],"product":"Oligomeric mitochondrial matrix chaperone; cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002666","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR258C"}


id: YDR259C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YAP6","product":"Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002667","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR259C"}


id: YDR260C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04520":null,"YDR260C":null},"has_protein_features":false,"name":"SWM1","ortholog_annotations":[{"gene_uniquename":"YDR260C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04520","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the anaphase-promoting complex (APC); APC is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002668","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR260C"}


id: YDR261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01171":null,"SJAG_01888":null,"SJAG_05001":null,"YDR261C":null},"has_protein_features":false,"name":"EXG2","ortholog_annotations":[{"gene_uniquename":"YDR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01171","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01888","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05001","reference_uniquename":"PMID:29761456"}],"product":"Exo-1,3-beta-glucanase; involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR261C"}


id: YDR262W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03998":null,"YDR262W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR262W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03998","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002670","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR262W"}


id: YDR263C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01832":null,"YDR263C":null},"has_protein_features":false,"name":"DIN7","ortholog_annotations":[{"gene_uniquename":"YDR263C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01832","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial nuclease functioning in DNA repair and replication; modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination; DIN7 has a paralog, EXO1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR263C"}


id: YDR264C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01112":null,"YDR264C":null},"has_protein_features":false,"name":"AKR1","ortholog_annotations":[{"gene_uniquename":"YDR264C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01112","reference_uniquename":"PMID:29761456"}],"product":"Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication; any of several human homologs encoding DHHC-type zinc fingers (ZDHHC) can complement temperature sensitivity of yeast akr1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR264C"}


id: YDR265W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01165":null,"YDR265W":null},"has_protein_features":false,"name":"PEX10","ortholog_annotations":[{"gene_uniquename":"YDR265W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01165","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal membrane E3 ubiquitin ligase; required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR265W"}


id: YDR266C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02746":null,"YDR266C":null},"has_protein_features":false,"name":"HEL2","ortholog_annotations":[{"gene_uniquename":"YDR266C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02746","reference_uniquename":"PMID:29761456"}],"product":"RING finger ubiquitin ligase (E3); subunit of ribosome-associated quality control trigger complex (RQT); involved in ubiquitination and degradation of excess histones; interacts with Ubc4p and Rad53p; required to trigger ribosome-associated quality control (RQC) and canonical no-go decay; ubiquitinates Rps20 and Rps3; binds to ribosomal RNA, mRNA and tRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002674","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR266C"}


id: YDR267C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02895":null,"YDR267C":null},"has_protein_features":false,"name":"CIA1","ortholog_annotations":[{"gene_uniquename":"YDR267C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02895","reference_uniquename":"PMID:29761456"}],"product":"Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at late step of Fe-S cluster assembly; forms CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation and maturation of a subset of cytosolic and nuclear proteins involved in methionine biosynthesis, DNA replication and repair, transcription and telomere maintenance; contains WD40 repeats; human homolog CIAO1 complements the yeast cia1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002675","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR267C"}


id: YDR268W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04840":null,"YDR268W":null},"has_protein_features":false,"name":"MSW1","ortholog_annotations":[{"gene_uniquename":"YDR268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04840","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial tryptophanyl-tRNA synthetase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR268W"}


id: YDR269C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR269C"}


id: YDR270W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02399":null,"YDR270W":null},"has_protein_features":false,"name":"CCC2","ortholog_annotations":[{"gene_uniquename":"YDR270W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02399","reference_uniquename":"PMID:29761456"}],"product":"Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; similar to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism; human homologs ATP7A and ATP7B both complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR270W"}


id: YDR271C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W","secondary_identifier":"SGD:S000002679","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR271C"}


id: YDR272W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01596":null,"YDR272W":null},"has_protein_features":false,"name":"GLO2","ortholog_annotations":[{"gene_uniquename":"YDR272W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01596","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO2 has a paralog, GLO4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002680","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR272W"}


id: YDR273W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05335":null,"YDR273W":null},"has_protein_features":false,"name":"DON1","ortholog_annotations":[{"gene_uniquename":"YDR273W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05335","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific component of the spindle pole body; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane (PSM) during meiosis II; required for PSM growth and closure; DON1 has a paralog, CUE5, that arose from the whole genome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002681","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR273W"}


id: YDR274C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YDR274C is not an essential gene","secondary_identifier":"SGD:S000002682","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR274C"}


id: YDR275W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BSC2","product":"Protein of unknown function involved in multidrug resistance; inhibits oxidative damage induced by amphotericin B; overexpression increases flocculation, biofilm formation, invasive and pseudohyphal growth; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; null mutant displays increased translation rate and increased readthrough of premature stop codons; BSC2 has a paralog, IRC23, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002683","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR275W"}


id: YDR276C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00372":null,"YDR276C":null},"has_protein_features":false,"name":"PMP3","ortholog_annotations":[{"gene_uniquename":"YDR276C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00372","reference_uniquename":"PMID:29761456"}],"product":"Small plasma membrane protein; confers resistance to amphotericin B and is a potential target of this common antifungal drug; related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature; not essential for viability; deletion causes hyperpolarization of the plasma membrane potential","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR276C"}


id: YDR277C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MTH1","product":"Negative regulator of the glucose-sensing signal transduction pathway; required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation; MTH1 has a paralog, STD1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002685","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR277C"}


id: YDR278C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YDR278C is not an essential gene","secondary_identifier":"SGD:S000002686","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR278C"}


id: YDR279W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00400":null,"YDR279W":null},"has_protein_features":false,"name":"RNH202","ortholog_annotations":[{"gene_uniquename":"YDR279W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00400","reference_uniquename":"PMID:29761456"}],"product":"Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS2 that causes Aicardi-Goutieres syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002687","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR279W"}


id: YDR280W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04824":null,"YDR280W":null},"has_protein_features":false,"name":"RRP45","ortholog_annotations":[{"gene_uniquename":"YDR280W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04824","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002688","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR280W"}


id: YDR281C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PHM6","product":"Protein of unknown function; expression is regulated by phosphate levels","secondary_identifier":"SGD:S000002689","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR281C"}


id: YDR282C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01174":null,"SJAG_02548":null,"YDR282C":null},"has_protein_features":false,"name":"MRX10","ortholog_annotations":[{"gene_uniquename":"YDR282C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01174","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR282C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02548","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein of unknown function; associates with mitochondrial ribosome; localizes to the inner membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002690","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR282C"}


id: YDR283C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00169":null,"YDR283C":null},"has_protein_features":false,"name":"GCN2","ortholog_annotations":[{"gene_uniquename":"YDR283C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00169","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002691","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR283C"}


id: YDR284C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02356":null,"YDR284C":null},"has_protein_features":false,"name":"DPP1","ortholog_annotations":[{"gene_uniquename":"YDR284C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02356","reference_uniquename":"PMID:29761456"}],"product":"Diacylglycerol pyrophosphate (DGPP) phosphatase; zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002692","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR284C"}


id: YDR285W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ZIP1","product":"Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; required for meiotic recombination between non-allelc sites; potential Cdc28p substrate","secondary_identifier":"SGD:S000002693","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR285W"}


id: YDR286C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MGP12","product":"Mitochondrial protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site","secondary_identifier":"SGD:S000002694","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR286C"}


id: YDR287W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"INM2","product":"Inositol monophosphatase; involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy","secondary_identifier":"SGD:S000002695","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR287W"}


id: YDR288W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03702":null,"YDR288W":null},"has_protein_features":false,"name":"NSE3","ortholog_annotations":[{"gene_uniquename":"YDR288W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03702","reference_uniquename":"PMID:29761456"}],"product":"Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002696","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR288W"}


id: YDR289C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00448":null,"YDR289C":null},"has_protein_features":false,"name":"RTT103","ortholog_annotations":[{"gene_uniquename":"YDR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00448","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in transcription termination by RNA polymerase II; interacts with exonuclease Rat1p and Rai1p; has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002697","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR289C"}


id: YDR290W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103","secondary_identifier":"SGD:S000002698","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR290W"}


id: YDR291W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02200":null,"YDR291W":null},"has_protein_features":false,"name":"HRQ1","ortholog_annotations":[{"gene_uniquename":"YDR291W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02200","reference_uniquename":"PMID:29761456"}],"product":"3'-5' DNA helicase of the conserved RecQ family; involved in Pso2p-mediated interstrand crosslink repair; acts with Rad4p in nucleotide-excision repair; binds telomeres, modulates telomerase activity with Pif1p and inhibits telomere addition to dsDNA breaks; role in telomerase-independent telomere maintenance; lacks ssDNA annealing and strand exchange activities; human RecQL4, a structural and functional homolog, is involved in Rothmund-Thomson, Baller-Gerold and RAPADILINO syndromes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002699","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR291W"}


id: YDR292C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01558":null,"YDR292C":null},"has_protein_features":false,"name":"SRP101","ortholog_annotations":[{"gene_uniquename":"YDR292C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01558","reference_uniquename":"PMID:29761456"}],"product":"Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002700","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR292C"}


id: YDR293C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01822":null,"SJAG_03132":null,"YDR293C":null},"has_protein_features":false,"name":"SSD1","ortholog_annotations":[{"gene_uniquename":"YDR293C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01822","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR293C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03132","reference_uniquename":"PMID:29761456"}],"product":"Translational repressor;  involved in polar growth, wall integrity, autodiploidization; regulated by Cbk1p phosphorylation to affect bud-specific translational control and localization of specific mRNAs; binds 5'UTRs of mRNAs encoding cell wall proteins; recognizes CNYTCNYT motif in RNA; interacts with TOR pathway components; nucleocytoplasmic shuttling appears to be critical to Ssd1p function; W303 lacks a functional SSD1 gene product; pseudonuclease descended from Dis3L2-family nucleases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002701","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR293C"}


id: YDR294C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DPL1","product":"Dihydrosphingosine phosphate lyase; regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate","secondary_identifier":"SGD:S000002702","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR294C"}


id: YDR295C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03685":null,"YDR295C":null},"has_protein_features":false,"name":"HDA2","ortholog_annotations":[{"gene_uniquename":"YDR295C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03685","reference_uniquename":"PMID:29761456"}],"product":"Subunit of HDA1 histone deacetylase complex; tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance; Hda2p relocalizes to cytosol in response to hypoxia; other members of the HDA1 histone deacetylase complex, which regulates aging through trehalose metabolism, are Hda1p and Hda3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002703","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR295C"}


id: YDR296W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03402":null,"YDR296W":null},"has_protein_features":false,"name":"MHR1","ortholog_annotations":[{"gene_uniquename":"YDR296W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03402","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; also involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR296W"}


id: YDR297W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05311":null,"YDR297W":null},"has_protein_features":false,"name":"SUR2","ortholog_annotations":[{"gene_uniquename":"YDR297W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05311","reference_uniquename":"PMID:29761456"}],"product":"Sphinganine C4-hydroxylase; catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002705","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR297W"}


id: YDR298C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00133":null,"YDR298C":null},"has_protein_features":false,"name":"ATP5","ortholog_annotations":[{"gene_uniquename":"YDR298C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00133","reference_uniquename":"PMID:29761456"}],"product":"Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002706","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR298C"}


id: YDR299W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01604":null,"YDR299W":null},"has_protein_features":false,"name":"BFR2","ortholog_annotations":[{"gene_uniquename":"YDR299W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01604","reference_uniquename":"PMID:29761456"}],"product":"Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002707","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR299W"}


id: YDR300C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03457":null,"YDR300C":null},"has_protein_features":false,"name":"PRO1","ortholog_annotations":[{"gene_uniquename":"YDR300C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03457","reference_uniquename":"PMID:29761456"}],"product":"Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002708","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR300C"}


id: YDR301W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03233":null,"YDR301W":null},"has_protein_features":false,"name":"CFT1","ortholog_annotations":[{"gene_uniquename":"YDR301W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03233","reference_uniquename":"PMID:29761456"}],"product":"RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002709","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR301W"}


id: YDR302W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02488":null,"YDR302W":null},"has_protein_features":false,"name":"GPI11","ortholog_annotations":[{"gene_uniquename":"YDR302W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02488","reference_uniquename":"PMID:29761456"}],"product":"ER membrane protein involved in a late step of GPI anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated glycosylphosphatidylinositol (GPI) intermediate; human PIG-Fp is a functional homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002710","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR302W"}


id: YDR303C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RSC3","product":"Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; RSC3 has a paralog, RSC30, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002711","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR303C"}


id: YDR304C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02413":null,"YDR304C":null},"has_protein_features":false,"name":"CPR5","ortholog_annotations":[{"gene_uniquename":"YDR304C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02413","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the ER; catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER; CPR5 has a paralog, CPR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002712","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR304C"}


id: YDR305C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04169":null,"YDR305C":null},"has_protein_features":false,"name":"HNT2","ortholog_annotations":[{"gene_uniquename":"YDR305C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04169","reference_uniquename":"PMID:29761456"}],"product":"Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002713","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR305C"}


id: YDR306C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01392":null,"YDR306C":null},"has_protein_features":false,"name":"PFU1","ortholog_annotations":[{"gene_uniquename":"YDR306C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01392","reference_uniquename":"PMID:29761456"}],"product":"F-box protein that regulates pheromone-dependent morphogenesis; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002714","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR306C"}


id: YDR307W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01491":null,"YDR307W":null},"has_protein_features":false,"name":"PMT7","ortholog_annotations":[{"gene_uniquename":"YDR307W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01491","reference_uniquename":"PMID:26896847"}],"product":"Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000002715","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR307W"}


id: YDR308C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05203":null,"YDR308C":null},"has_protein_features":false,"name":"SRB7","ortholog_annotations":[{"gene_uniquename":"YDR308C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05203","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002716","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR308C"}


id: YDR309C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GIC2","product":"Rho-family GTPase interacting protein and Cdc42p effector; required with Gic1p for cell polarity establishment and initiation of budding; involved in recruitment of septins to the presumptive bud site; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region; gic1 gic2 double mutants are defective for polarizing Cdc42p at elevated temperature, so may function both up- and downstream of Cdc42p; regulates mitotic exit","secondary_identifier":"SGD:S000002717","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR309C"}


id: YDR310C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SUM1","product":"Transcriptional repressor that regulates middle-sporulation genes; required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint","secondary_identifier":"SGD:S000002718","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR310C"}


id: YDR311W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00512":null,"YDR311W":null},"has_protein_features":false,"name":"TFB1","ortholog_annotations":[{"gene_uniquename":"YDR311W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00512","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TFIIH and nucleotide excision repair factor 3 complexes; required for nucleotide excision repair, target for transcriptional activators; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002719","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR311W"}


id: YDR312W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02427":null,"YDR312W":null},"has_protein_features":false,"name":"SSF2","ortholog_annotations":[{"gene_uniquename":"YDR312W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02427","reference_uniquename":"PMID:29761456"}],"product":"Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002720","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR312W"}


id: YDR313C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00173":null,"YDR313C":null},"has_protein_features":false,"name":"PIB1","ortholog_annotations":[{"gene_uniquename":"YDR313C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00173","reference_uniquename":"PMID:29761456"}],"product":"RING-type ubiquitin ligase of the endosomal and vacuolar membranes; binds phosphatidylinositol 3-phosphate; contains a FYVE finger domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002721","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR313C"}


id: YDR314C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01049":null,"SJAG_01887":null,"YDR314C":null},"has_protein_features":false,"name":"RAD34","ortholog_annotations":[{"gene_uniquename":"YDR314C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01049","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR314C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01887","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in nucleotide excision repair (NER); homologous to RAD4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002722","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR314C"}


id: YDR315C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01148":null,"YDR315C":null},"has_protein_features":false,"name":"IPK1","ortholog_annotations":[{"gene_uniquename":"YDR315C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01148","reference_uniquename":"PMID:29761456"}],"product":"Inositol 1,3,4,5,6-pentakisphosphate 2-kinase; nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable; human IPPK can complement ipk1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002723","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR315C"}


id: YDR316W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05693":null,"YDR316W":null},"has_protein_features":false,"name":"OMS1","ortholog_annotations":[{"gene_uniquename":"YDR316W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05693","reference_uniquename":"PMID:29761456"}],"product":"Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif and is predicted to be an RNA methyltransferase; multicopy suppressor of respiratory defects caused by OXA1 mutations","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR316W"}


id: YDR317W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HIM1","product":"Protein of unknown function involved in DNA repair","secondary_identifier":"SGD:S000002725","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR317W"}


id: YDR318W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04581":null,"YDR318W":null},"has_protein_features":false,"name":"MCM21","ortholog_annotations":[{"gene_uniquename":"YDR318W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04581","reference_uniquename":"PMID:29761456"}],"product":"Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; modified by sumoylation; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002726","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR318W"}


id: YDR319C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01180":null,"YDR319C":null},"has_protein_features":false,"name":"YFT2","ortholog_annotations":[{"gene_uniquename":"YDR319C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01180","reference_uniquename":"PMID:29761456"}],"product":"Protein needed for ER membrane biosynthesis in response to ER stress; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis; homologous to human FIT2/FITM2, a fatty acyl-CoA diphosphatase; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002727","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR319C"}


id: YDR320C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05296":null,"YDR320C":null},"has_protein_features":false,"name":"SWA2","ortholog_annotations":[{"gene_uniquename":"YDR320C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05296","reference_uniquename":"PMID:29761456"}],"product":"Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles; required for propagation of [URE3] prion variant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002728","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR320C"}


id: YDR320C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05319":null,"YDR320C-A":null},"has_protein_features":false,"name":"DAD4","ortholog_annotations":[{"gene_uniquename":"YDR320C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05319","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007604","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR320C-A"}


id: YDR320W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene DAD4/YDR320C-A","secondary_identifier":"SGD:S000028821","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR320W-B"}


id: YDR321W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ASP1","product":"Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia; important enzyme for the treatment of acute lymphoblastic leukemia; has low glutaminase activity and dependence; synthesized constitutively","secondary_identifier":"SGD:S000002729","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR321W"}


id: YDR322C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04122":null,"YDR322C-A":null},"has_protein_features":false,"name":"TIM11","ortholog_annotations":[{"gene_uniquename":"YDR322C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04122","reference_uniquename":"PMID:29761456"}],"product":"Subunit e of mitochondrial F1F0-ATPase; ATPase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase, which in turn determines the shape of inner membrane cristae","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR322C-A"}


id: YDR322W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01727":null,"YDR322W":null},"has_protein_features":false,"name":"MRPL35","ortholog_annotations":[{"gene_uniquename":"YDR322W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01727","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; involved together with Mrp7p in assembly of cytochrome c oxidase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002730","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR322W"}


id: YDR323C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02587":null,"YDR323C":null},"has_protein_features":false,"name":"PEP7","ortholog_annotations":[{"gene_uniquename":"YDR323C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02587","reference_uniquename":"PMID:29761456"}],"product":"Adaptor protein involved in vesicle-mediated vacuolar protein sorting; multivalent adaptor protein; facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002731","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR323C"}


id: YDR324C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00879":null,"YDR324C":null},"has_protein_features":false,"name":"UTP4","ortholog_annotations":[{"gene_uniquename":"YDR324C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00879","reference_uniquename":"PMID:29761456"}],"product":"Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript; Small Subunit processome is also known as SSU processome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002732","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR324C"}


id: YDR325W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03682":null,"YDR325W":null},"has_protein_features":false,"name":"YCG1","ortholog_annotations":[{"gene_uniquename":"YDR325W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03682","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding by the complex; required for tRNA genes clustering at the nucleolus; required for replication slow zone breakage following Mec1p inactivation; transcription is cell cycle regulated, peaking in mitosis and declining in G1; protein is constitutively degraded by the proteasome; rate limiting for condensin recruitment to chromatin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002733","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR325W"}


id: YDR326C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01329":null,"YDR326C":null},"has_protein_features":false,"name":"YSP2","ortholog_annotations":[{"gene_uniquename":"YDR326C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01329","reference_uniquename":"PMID:29761456"}],"product":"Sterol-binding protein; has a probable role in retrograde transport of sterols from the plasma membrane to the ER; contains two StART-like domains that bind sterols and a GRAM domain; co-localizes to puncta in the cortical ER with Sip3p; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002734","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR326C"}


id: YDR327W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SKP1","secondary_identifier":"SGD:S000002735","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR327W"}


id: YDR328C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03219":null,"YDR328C":null},"has_protein_features":false,"name":"SKP1","ortholog_annotations":[{"gene_uniquename":"YDR328C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03219","reference_uniquename":"PMID:29761456"}],"product":"Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002736","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR328C"}


id: YDR329C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04763":null,"YDR329C":null},"has_protein_features":false,"name":"PEX3","ortholog_annotations":[{"gene_uniquename":"YDR329C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04763","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal membrane protein (PMP); required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002737","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR329C"}


id: YDR330W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02021":null,"YDR330W":null},"has_protein_features":false,"name":"UBX5","ortholog_annotations":[{"gene_uniquename":"YDR330W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02021","reference_uniquename":"PMID:29761456"}],"product":"UBX domain-containing protein that interacts with Cdc48p; ubiquitin regulatory X is also known as UBX","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002738","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR330W"}


id: YDR331W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03672":null,"YDR331W":null},"has_protein_features":false,"name":"GPI8","ortholog_annotations":[{"gene_uniquename":"YDR331W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03672","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of the ER membrane GPI transamidase complex; involved in adding glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; luminally-oriented type I integral membrane glycoprotein of the ER; human PIGK protein is a functional homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002739","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR331W"}


id: YDR332W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04064":null,"YDR332W":null},"has_protein_features":false,"name":"IRC3","ortholog_annotations":[{"gene_uniquename":"YDR332W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04064","reference_uniquename":"PMID:29761456"}],"product":"Double-stranded DNA-dependent helicase of the DExH/D-box family; branch point-binding helicase that preferentially unwinds the nascent lagging strand with a 3' to 5' polarity at a replication fork; contains double-stranded DNA translocase activity; responsible for DNA branch migration; required for maintenance of the mitochondrial (mt) genome; localizes to the mitochondrial matrix; monomeric","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002740","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR332W"}


id: YDR333C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01497":null,"YDR333C":null},"has_protein_features":false,"name":"RQC1","ortholog_annotations":[{"gene_uniquename":"YDR333C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01497","reference_uniquename":"PMID:29761456"}],"product":"Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Rkr1p-Rqc2p-Cdc48p-Npl4p-Ufd1p) is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Rkr1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002741","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR333C"}


id: YDR334W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02571":null,"YDR334W":null},"has_protein_features":false,"name":"SWR1","ortholog_annotations":[{"gene_uniquename":"YDR334W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02571","reference_uniquename":"PMID:29761456"}],"product":"Swi2/Snf2-related ATPase; catalytic subunit of SWR1 complex, which exchanges histone variant H2A.Z (Htz1p) for chromatin-bound histone H2A; N-terminus can deliver H2A.Z-H2B dimer to DNA-(H3-H4)2 tetrasome; relocalizes to cytosol in response to hypoxia; chronological aging factor, mediates lifespan extension by dietary restriction","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002742","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR334W"}


id: YDR335W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01534":null,"YDR335W":null},"has_protein_features":false,"name":"MSN5","ortholog_annotations":[{"gene_uniquename":"YDR335W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01534","reference_uniquename":"PMID:29761456"}],"product":"Karyopherin; involved in nuclear import and export of proteins, including import of replication protein A and export of Far1p and transcription factors Swi5p, Swi6p, Msn2p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm; exportin-5 homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002743","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR335W"}


id: YDR336W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MRX8","product":"Protein that associates with mitochondrial ribosome; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene","secondary_identifier":"SGD:S000002744","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR336W"}


id: YDR337W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03053":null,"YDR337W":null},"has_protein_features":false,"name":"MRPS28","ortholog_annotations":[{"gene_uniquename":"YDR337W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03053","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002745","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR337W"}


id: YDR338C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01145":null,"SJAG_03951":null,"YDR338C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR338C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01145","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR338C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03951","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002746","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR338C"}


id: YDR339C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00772":null,"YDR339C":null},"has_protein_features":false,"name":"FCF1","ortholog_annotations":[{"gene_uniquename":"YDR339C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00772","reference_uniquename":"PMID:29761456"}],"product":"PINc domain endonuclease; required for early cleavage of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002747","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR339C"}


id: YDR340W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000002748","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR340W"}


id: YDR341C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00653":null,"YDR341C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR341C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00653","reference_uniquename":"PMID:29761456"}],"product":"Arginyl-tRNA synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDR341C has a paralog, MSR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002749","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR341C"}


id: YDR342C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YDR342C":null},"has_protein_features":false,"name":"HXT7","ortholog_annotations":[{"gene_uniquename":"YDR342C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR342C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR342C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR342C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR342C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR342C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR342C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002750","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR342C"}


id: YDR343C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YDR343C":null},"has_protein_features":false,"name":"HXT6","ortholog_annotations":[{"gene_uniquename":"YDR343C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR343C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR343C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR343C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR343C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR343C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR343C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3; HXT6 has a paralog, HXT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002751","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR343C"}


id: YDR344C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000002752","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR344C"}


id: YDR345C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YDR345C":null},"has_protein_features":false,"name":"HXT3","ortholog_annotations":[{"gene_uniquename":"YDR345C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR345C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR345C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR345C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR345C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR345C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR345C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:26896847"}],"product":"Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000002753","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR345C"}


id: YDR346C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03690":null,"YDR346C":null},"has_protein_features":false,"name":"SVF1","ortholog_annotations":[{"gene_uniquename":"YDR346C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03690","reference_uniquename":"PMID:29761456"}],"product":"Protein with a potential role in cell survival pathways; required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002754","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR346C"}


id: YDR347W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01734":null,"SJAG_04788":null,"YDR347W":null},"has_protein_features":false,"name":"MRP1","ortholog_annotations":[{"gene_uniquename":"YDR347W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01734","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR347W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04788","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002755","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR347W"}


id: YDR348C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04050":null,"YDR348C":null},"has_protein_features":false,"name":"PAL1","ortholog_annotations":[{"gene_uniquename":"YDR348C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04050","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function thought to be involved in endocytosis; physically interacts with Ede1p and is found at endocytic sites at cell periphery during early stages of endocytosis; green fluorescent protein (GFP)-fusion protein localizes to bud neck; potential Cdc28p substrate; similar to S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress; PAL1 has a paralog, YHR097C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002756","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR348C"}


id: YDR349C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00109":null,"SJAG_00254":null,"SJAG_00784":null,"SJAG_02260":null,"YDR349C":null},"has_protein_features":false,"name":"YPS7","ortholog_annotations":[{"gene_uniquename":"YDR349C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00109","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR349C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00254","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR349C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00784","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR349C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02260","reference_uniquename":"PMID:29761456"}],"product":"Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002757","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR349C"}


id: YDR350C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATP22","product":"Specific translational activator for the mitochondrial ATP6 mRNA; Atp6p encodes a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane","secondary_identifier":"SGD:S000002758","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR350C"}


id: YDR351W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SBE2","product":"Protein required for bud growth; involved in transport of cell wall components from the Golgi to the cell surface; SBE2 has a paralog, SBE22, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002759","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR351W"}


id: YDR352W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00051":null,"SJAG_04787":null,"YDR352W":null},"has_protein_features":false,"name":"YPQ2","ortholog_annotations":[{"gene_uniquename":"YDR352W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00051","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR352W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04787","reference_uniquename":"PMID:29761456"}],"product":"Putative vacuolar membrane transporter for cationic amino acids; involved in vacuolar export of arginine under nitrogen starvation conditions; appears to be inactive under nitrogen replete conditions; may contribute to amino acid homeostasis; vacuolar membrane protein; member of the PQ-loop family, containing seven transmembrane domains; homologous to the human lysosomal cationic amino acid exporter PQLC2; null mutant is functionally complemented by the rat PQLC2 vacuolar transporter","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002760","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR352W"}


id: YDR353W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03653":null,"SJAG_04399":null,"YDR353W":null},"has_protein_features":false,"name":"TRR1","ortholog_annotations":[{"gene_uniquename":"YDR353W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03653","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR353W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04399","reference_uniquename":"PMID:26896847"}],"product":"Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002761","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR353W"}


id: YDR354C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps TRP4; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR354C-A"}


id: YDR354W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03167":null,"YDR354W":null},"has_protein_features":false,"name":"TRP4","ortholog_annotations":[{"gene_uniquename":"YDR354W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03167","reference_uniquename":"PMID:29761456"}],"product":"Anthranilate phosphoribosyl transferase; transferase of the tryptophan biosynthetic pathway; catalyzes the phosphoribosylation of anthranilate; subject to the general control system of amino acid biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002762","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR354W"}


id: YDR355C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W","secondary_identifier":"SGD:S000002763","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR355C"}


id: YDR356W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02246":null,"YDR356W":null},"has_protein_features":false,"name":"SPC110","ortholog_annotations":[{"gene_uniquename":"YDR356W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02246","reference_uniquename":"PMID:29761456"}],"product":"Inner plaque spindle pole body (SPB) component; gamma-tubulin small complex (gamma-TuSC) receptor that interacts with Spc98p to recruit the complex to the nuclear side of the SPB, connecting nuclear microtubules to the SPB; promotes gamma-TuSC assembly and oligomerization to initiate microtubule nucleation; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner; ortholog of human pericentrin (kendrin)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002764","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR356W"}


id: YDR357C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CNL1","product":"Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000002765","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR357C"}


id: YDR358W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02912":null,"SJAG_03756":null,"YDR358W":null},"has_protein_features":false,"name":"GGA1","ortholog_annotations":[{"gene_uniquename":"YDR358W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02912","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR358W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03756","reference_uniquename":"PMID:29761456"}],"product":"Golgi-localized protein with homology to gamma-adaptin; interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi; GGA1 has a paralog, GGA2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002766","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR358W"}


id: YDR359C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00783":null,"YDR359C":null},"has_protein_features":false,"name":"EAF1","ortholog_annotations":[{"gene_uniquename":"YDR359C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00783","reference_uniquename":"PMID:29761456"}],"product":"Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002767","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR359C"}


id: YDR360W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OPI7","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C","secondary_identifier":"SGD:S000002768","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR360W"}


id: YDR361C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00753":null,"YDR361C":null},"has_protein_features":false,"name":"BCP1","ortholog_annotations":[{"gene_uniquename":"YDR361C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00753","reference_uniquename":"PMID:29761456"}],"product":"Essential nuclear chaperone for ribosomal protein Rpl23p; involved in nuclear export of Mss4p; Mss4p is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002769","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR361C"}


id: YDR362C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00585":null,"YDR362C":null},"has_protein_features":false,"name":"TFC6","ortholog_annotations":[{"gene_uniquename":"YDR362C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00585","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002770","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR362C"}


id: YDR363W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00177":null,"YDR363W":null},"has_protein_features":false,"name":"ESC2","ortholog_annotations":[{"gene_uniquename":"YDR363W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00177","reference_uniquename":"PMID:29761456"}],"product":"Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002771","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR363W"}


id: YDR363W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01652":null,"YDR363W-A":null},"has_protein_features":false,"name":"SEM1","ortholog_annotations":[{"gene_uniquename":"YDR363W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01652","reference_uniquename":"PMID:29761456"}],"product":"19S proteasome regulatory particle lid subcomplex component; role in Ub-dependent proteolysis and proteasome stability; involved in TREX-2 mediated mRNA export, and in the prevention of transcription-associated genome instability; ubiquitinated by Nedd4-like E3-ligase, Rsp5p; human ortholog DSS1, a BRCA1 binding protein implicated in cancer, complements the yeast null; drives trinucleotide repeat expansion; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR363W-A"}


id: YDR364C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00639":null,"YDR364C":null},"has_protein_features":false,"name":"CDC40","ortholog_annotations":[{"gene_uniquename":"YDR364C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00639","reference_uniquename":"PMID:29761456"}],"product":"Pre-mRNA splicing factor; important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression, particularly at the G1/S phase transition; required for DNA synthesis during mitosis and meiosis; has WD repeats; thermosensitivity of the cdc40 null mutant is functionally complemented by a chimeric construct containing the N-terminal 156 amino acids of yeast Cdc40p fused to the C-terminal two thirds (297 amino acids) of human CDC40","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002772","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR364C"}


id: YDR365C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00813":null,"YDR365C":null},"has_protein_features":false,"name":"ESF1","ortholog_annotations":[{"gene_uniquename":"YDR365C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00813","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002773","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR365C"}


id: YDR366C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MOR1","product":"Putative protein of unknown function","secondary_identifier":"SGD:S000002774","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR366C"}


id: YDR367W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03015":null,"YDR367W":null},"has_protein_features":false,"name":"KEI1","ortholog_annotations":[{"gene_uniquename":"YDR367W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03015","reference_uniquename":"PMID:29761456"}],"product":"Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002775","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR367W"}


id: YDR368W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02010":null,"YDR368W":null},"has_protein_features":false,"name":"YPR1","ortholog_annotations":[{"gene_uniquename":"YDR368W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02010","reference_uniquename":"PMID:29761456"}],"product":"NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; human homolog AKR1B1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002776","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR368W"}


id: YDR369C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00640":null,"YDR369C":null},"has_protein_features":false,"name":"XRS2","ortholog_annotations":[{"gene_uniquename":"YDR369C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00640","reference_uniquename":"PMID:29761456"}],"product":"FHA domain-containing component of the Mre11 complex; MRE11-RAD50-XRS2 complex is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling;  FHA domain is required for activation of Tel1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002777","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR369C"}


id: YDR370C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DXO1","product":"mRNA 5'-end-capping quality-control protein; has distributive, 5'-3' exoRNase activity; involved in the decapping of nicotinamide adenine dinucleotide (NAD) capped nuclear NAD-RNAs; similar to Rai1p","secondary_identifier":"SGD:S000002778","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR370C"}


id: YDR371C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene CTS2/YDR371W; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028822","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR371C-A"}


id: YDR371W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00620":null,"YDR371W":null},"has_protein_features":false,"name":"CTS2","ortholog_annotations":[{"gene_uniquename":"YDR371W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00620","reference_uniquename":"PMID:29761456"}],"product":"Putative chitinase; functionally complements A. gossypii cts2 mutant sporulation defect","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002779","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR371W"}


id: YDR372C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01516":null,"YDR372C":null},"has_protein_features":false,"name":"VPS74","ortholog_annotations":[{"gene_uniquename":"YDR372C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01516","reference_uniquename":"PMID:29761456"}],"product":"Golgi PI4K effector, PtdIns4P sensor, and retention receptor; interacts with glycosyltransferases, and in the PtdIns4P-bound state mediates retention of these enzymes in the Golgi; PtdIns4P sensor that limits PI4K signaling and regulates lipid homeostasis, interacting with the catalytic domain of Sac1p, the major PtdIns4P phosphatase, directing dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; contributes to telomere function; ortholog of human GOLPH3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002780","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR372C"}


id: YDR373W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00296":null,"YDR373W":null},"has_protein_features":false,"name":"FRQ1","ortholog_annotations":[{"gene_uniquename":"YDR373W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00296","reference_uniquename":"PMID:29761456"}],"product":"N-myristoylated calcium-binding protein; may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily; human NCS1 functionally complements the heat sensitivity of a frq1 ts mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002781","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR373W"}


id: YDR374C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02622":null,"YDR374C":null},"has_protein_features":false,"name":"PHO92","ortholog_annotations":[{"gene_uniquename":"YDR374C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02622","reference_uniquename":"PMID:29761456"}],"product":"Posttranscriptional regulator of phosphate and glucose metabolism; facilitates PHO4 mRNA degradation by interacting with Pop2p; regulates PHO4 mRNA stability by binding to PHO4's 3'UTR in a phosphate-dependent manner; contains highly conserved YTH (YT521-B Homology) domain that exhibits RNA-binding activity; human homolog YTHDF2 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002782","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR374C"}


id: YDR374W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05321":null,"YDR374W-A":null},"has_protein_features":false,"name":"WIP1","ortholog_annotations":[{"gene_uniquename":"YDR374W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05321","reference_uniquename":"PMID:29761456"}],"product":"Kinetochore localized protein of unknown function; interacts with Cnn1p (CENP-T); orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-W and fission yeast new1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000113553","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR374W-A"}


id: YDR375C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01405":null,"YDR375C":null},"has_protein_features":false,"name":"BCS1","ortholog_annotations":[{"gene_uniquename":"YDR375C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01405","reference_uniquename":"PMID:29761456"}],"product":"Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane and delivers it to an assembly intermediate of respiratory Complex III; also required for assembly of the Qcr10p subunit; mutation is functionally complemented by human homolog BCS1L, linked to neonatal diseases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002783","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR375C"}


id: YDR376W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01063":null,"YDR376W":null},"has_protein_features":false,"name":"ARH1","ortholog_annotations":[{"gene_uniquename":"YDR376W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01063","reference_uniquename":"PMID:29761456"}],"product":"Oxidoreductase of the mitochondrial inner membrane; involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR376W"}


id: YDR377W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05204":null,"YDR377W":null},"has_protein_features":false,"name":"ATP17","ortholog_annotations":[{"gene_uniquename":"YDR377W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05204","reference_uniquename":"PMID:29761456"}],"product":"Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002785","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR377W"}


id: YDR378C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03954":null,"YDR378C":null},"has_protein_features":false,"name":"LSM6","ortholog_annotations":[{"gene_uniquename":"YDR378C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03954","reference_uniquename":"PMID:29761456"}],"product":"Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002786","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR378C"}


id: YDR379C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_07005":null,"YDR379C-A":null},"has_protein_features":false,"name":"SDH6","ortholog_annotations":[{"gene_uniquename":"YDR379C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07005","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; member of the LYR protein family; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007605","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR379C-A"}


id: YDR379W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04522":null,"SJAG_04765":null,"YDR379W":null},"has_protein_features":false,"name":"RGA2","ortholog_annotations":[{"gene_uniquename":"YDR379W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04522","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR379W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04765","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p; RGA2 has a paralog, RGA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002787","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR379W"}


id: YDR380W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ARO10","product":"Phenylpyruvate decarboxylase; catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway; involved in protein N-terminal Met and Ala catabolism","secondary_identifier":"SGD:S000002788","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR380W"}


id: YDR381C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COI1","product":"Mitochondrial assembly factor; important for assembly of the mitochondrial respiratory chain bc1 complex (complex III), cytochrome oxidase (complex IV), and the complex III-complex IV supercomplex; embedded in the mitochondrial inner membrane, facing the intermembrane space","secondary_identifier":"SGD:S000007650","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR381C-A"}


id: YDR381W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01717":null,"YDR381W":null},"has_protein_features":false,"name":"YRA1","ortholog_annotations":[{"gene_uniquename":"YDR381W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01717","reference_uniquename":"PMID:29761456"}],"product":"Nuclear polyadenylated RNA-binding protein; required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; interacts with DBP2; inhibits the helicase activity of Dbp2; functionally redundant with Yra2p, another REF family member","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002789","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR381W"}


id: YDR382W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01128":null,"SJAG_02871":null,"YDR382W":null},"has_protein_features":false,"name":"RPP2B","ortholog_annotations":[{"gene_uniquename":"YDR382W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01128","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR382W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02871","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein P2 beta; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002790","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR382W"}


id: YDR383C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04255":null,"YDR383C":null},"has_protein_features":false,"name":"NKP1","ortholog_annotations":[{"gene_uniquename":"YDR383C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04255","reference_uniquename":"PMID:29761456"}],"product":"Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002791","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR383C"}


id: YDR384C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01505":null,"YDR384C":null},"has_protein_features":false,"name":"ATO3","ortholog_annotations":[{"gene_uniquename":"YDR384C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01505","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane protein, putative ammonium transporter; regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002792","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR384C"}


id: YDR385W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01438":null,"SJAG_05332":null,"YDR385W":null},"has_protein_features":false,"name":"EFT2","ortholog_annotations":[{"gene_uniquename":"YDR385W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01438","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR385W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05332","reference_uniquename":"PMID:29761456"}],"product":"Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002793","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR385W"}


id: YDR386W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01044":null,"YDR386W":null},"has_protein_features":false,"name":"MUS81","ortholog_annotations":[{"gene_uniquename":"YDR386W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01044","reference_uniquename":"PMID:29761456"}],"product":"Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); helix-hairpin-helix protein; phosphorylation of non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates function of Mms4p-Mus81p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002794","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR386W"}


id: YDR387C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03595":null,"SJAG_04506":null,"YDR387C":null},"has_protein_features":false,"name":"CIN10","ortholog_annotations":[{"gene_uniquename":"YDR387C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03595","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR387C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04506","reference_uniquename":"PMID:29761456"}],"product":"Putative transporter; member of the sugar porter family; non-essential gene; overexpression results in elevated colony sectoring, an indicator of chromosomal instability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002795","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR387C"}


id: YDR388W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00185":null,"YDR388W":null},"has_protein_features":false,"name":"RVS167","ortholog_annotations":[{"gene_uniquename":"YDR388W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00185","reference_uniquename":"PMID:29761456"}],"product":"Calmodulin-binding actin-associated protein; roles in endocytic membrane tabulation and constriction, and exocytosis; N-BAR domain protein that interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin; necessary for efficient trafficking of CoQ6 to mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002796","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR388W"}


id: YDR389W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04462":null,"YDR389W":null},"has_protein_features":false,"name":"SAC7","ortholog_annotations":[{"gene_uniquename":"YDR389W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04462","reference_uniquename":"PMID:29761456"}],"product":"GTPase activating protein (GAP) for Rho1p; regulator of a Tor2p-mediated, Rho1p GTPase switch that controls organization of the actin cytoskeleton; negative regulator of the RHO1-PKC1-MAPK cell integrity (CWI) and membrane fluidity homeostasis signaling pathways; potential Cdc28p substrate; SAC7 has a paralog, BAG7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002797","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR389W"}


id: YDR390C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00604":null,"YDR390C":null},"has_protein_features":false,"name":"UBA2","ortholog_annotations":[{"gene_uniquename":"YDR390C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00604","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002798","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR390C"}


id: YDR391C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01619":null,"YDR391C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR391C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01619","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002799","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR391C"}


id: YDR392W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03668":null,"YDR392W":null},"has_protein_features":false,"name":"SPT3","ortholog_annotations":[{"gene_uniquename":"YDR392W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03668","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SAGA and SAGA-like transcriptional regulatory complexes; interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002800","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR392W"}


id: YDR393W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04965":null,"YDR393W":null},"has_protein_features":false,"name":"SHE9","ortholog_annotations":[{"gene_uniquename":"YDR393W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04965","reference_uniquename":"PMID:29761456"}],"product":"Protein required for normal mitochondrial morphology; localized to mitochondrial inner membrane; may be involved in fission of the inner membrane; forms a homo-oligomeric complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002801","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR393W"}


id: YDR394W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04477":null,"YDR394W":null},"has_protein_features":false,"name":"RPT3","ortholog_annotations":[{"gene_uniquename":"YDR394W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04477","reference_uniquename":"PMID:29761456"}],"product":"ATPase of the 19S regulatory particle of the 26S proteasome; one of ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002802","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR394W"}


id: YDR395W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03693":null,"YDR395W":null},"has_protein_features":false,"name":"SXM1","ortholog_annotations":[{"gene_uniquename":"YDR395W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03693","reference_uniquename":"PMID:29761456"}],"product":"Nuclear transport factor (karyopherin); involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002803","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR395W"}


id: YDR396W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex","secondary_identifier":"SGD:S000002804","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR396W"}


id: YDR397C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03095":null,"YDR397C":null},"has_protein_features":false,"name":"NCB2","ortholog_annotations":[{"gene_uniquename":"YDR397C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03095","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta; complex also includes Bur6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002805","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR397C"}


id: YDR398W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02499":null,"SJAG_02702":null,"YDR398W":null},"has_protein_features":false,"name":"UTP5","ortholog_annotations":[{"gene_uniquename":"YDR398W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02499","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR398W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02702","reference_uniquename":"PMID:29761456"}],"product":"Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR398W"}


id: YDR399W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06634":null,"YDR399W":null},"has_protein_features":false,"name":"HPT1","ortholog_annotations":[{"gene_uniquename":"YDR399W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06634","reference_uniquename":"PMID:29761456"}],"product":"Dimeric hypoxanthine-guanine phosphoribosyltransferase; catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR399W"}


id: YDR400W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00957":null,"YDR400W":null},"has_protein_features":false,"name":"URH1","ortholog_annotations":[{"gene_uniquename":"YDR400W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00957","reference_uniquename":"PMID:29761456"}],"product":"Uridine nucleosidase (uridine-cytidine N-ribohydrolase); cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR400W"}


id: YDR401W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002809","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR401W"}


id: YDR402C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DIT2","product":"N-formyltyrosine oxidase; sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","secondary_identifier":"SGD:S000002810","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR402C"}


id: YDR403W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DIT1","product":"Sporulation-specific enzyme required for spore wall maturation; involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure","secondary_identifier":"SGD:S000002811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR403W"}


id: YDR404C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01436":null,"YDR404C":null},"has_protein_features":false,"name":"RPB7","ortholog_annotations":[{"gene_uniquename":"YDR404C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01436","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR404C"}


id: YDR405W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00799":null,"YDR405W":null},"has_protein_features":false,"name":"MRP20","ortholog_annotations":[{"gene_uniquename":"YDR405W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00799","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002813","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR405W"}


id: YDR406W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04277":null,"YDR406W":null},"has_protein_features":false,"name":"PDR15","ortholog_annotations":[{"gene_uniquename":"YDR406W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane ATP binding cassette (ABC) transporter; multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element; PDR15 has a paralog, PDR5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002814","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR406W"}


id: YDR406W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028543","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR406W-A"}


id: YDR407C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04358":null,"YDR407C":null},"has_protein_features":false,"name":"TRS120","ortholog_annotations":[{"gene_uniquename":"YDR407C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04358","reference_uniquename":"PMID:29761456"}],"product":"Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002815","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR407C"}


id: YDR408C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01814":null,"YDR408C":null},"has_protein_features":false,"name":"ADE8","ortholog_annotations":[{"gene_uniquename":"YDR408C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01814","reference_uniquename":"PMID:29761456"}],"product":"Phosphoribosyl-glycinamide transformylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002816","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR408C"}


id: YDR409W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00727":null,"YDR409W":null},"has_protein_features":false,"name":"SIZ1","ortholog_annotations":[{"gene_uniquename":"YDR409W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00727","reference_uniquename":"PMID:29761456"}],"product":"SUMO E3 ligase; promotes attachment of small ubiquitin-related modifier sumo (Smt3p) to primarily cytoplasmic proteins; regulates Rsp5p ubiquitin ligase activity and is in turn itself regulated by Rsp5p; required for sumoylation of septins and histone H3 variant Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; localizes to the septin ring; acts as an adapter between E2, Ubc9p and substrates; tends to compensate for survival of DNA damage in absence of Nfi1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002817","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR409W"}


id: YDR410C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05016":null,"YDR410C":null},"has_protein_features":false,"name":"STE14","ortholog_annotations":[{"gene_uniquename":"YDR410C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05016","reference_uniquename":"PMID:29761456"}],"product":"Farnesyl cysteine-carboxyl methyltransferase; mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002818","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR410C"}


id: YDR411C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00681":null,"SJAG_03841":null,"YDR411C":null},"has_protein_features":false,"name":"DFM1","ortholog_annotations":[{"gene_uniquename":"YDR411C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00681","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR411C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03841","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum (ER) localized protein; involved in ER-associated protein degradation (ERAD), ER stress, and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002819","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR411C"}


id: YDR412W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04767":null,"YDR412W":null},"has_protein_features":false,"name":"RRP17","ortholog_annotations":[{"gene_uniquename":"YDR412W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04767","reference_uniquename":"PMID:29761456"}],"product":"5' exoribonuclease required for 5' end processing of pre-60S rRNA; binds late pre-60S ribosomes, accompanying them from nucleolus to nuclear periphery; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; yeast null mutant is complemented by expression of human homolog NOL12","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002820","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR412W"}


id: YDR413C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing","secondary_identifier":"SGD:S000002821","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR413C"}


id: YDR414C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01001":null,"SJAG_04340":null,"YDR414C":null},"has_protein_features":false,"name":"ERD1","ortholog_annotations":[{"gene_uniquename":"YDR414C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01001","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR414C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04340","reference_uniquename":"PMID:29761456"}],"product":"Predicted membrane protein required for lumenal ER protein retention; recycles inorganic phosphate byproduct of glycosylation from ER and Golgi; involved in recycling of early Golgi glycosyltransferases from late to early Golgi compartments; mutants secrete the endogenous ER protein, BiP (Kar2p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002822","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR414C"}


id: YDR415C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative aminopeptidase; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to the vacuole","secondary_identifier":"SGD:S000002823","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR415C"}


id: YDR416W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00859":null,"YDR416W":null},"has_protein_features":false,"name":"SYF1","ortholog_annotations":[{"gene_uniquename":"YDR416W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00859","reference_uniquename":"PMID:29761456"}],"product":"Member of the NineTeen Complex (NTC); that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; relocalizes to the cytosol in response to hypoxia; homologs in human and C. elegans","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002824","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR416W"}


id: YDR417C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W","secondary_identifier":"SGD:S000002825","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR417C"}


id: YDR418W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02535":null,"SJAG_05248":null,"YDR418W":null},"has_protein_features":false,"name":"RPL12B","ortholog_annotations":[{"gene_uniquename":"YDR418W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02535","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR418W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05248","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002826","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR418W"}


id: YDR419W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04791":null,"YDR419W":null},"has_protein_features":false,"name":"RAD30","ortholog_annotations":[{"gene_uniquename":"YDR419W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04791","reference_uniquename":"PMID:29761456"}],"product":"DNA polymerase eta; involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; involved in formation of post-replicative damage-induced genome-wide cohesion; may also have a role in protection against mitochondrial mutagenesis; may be involved in meiosis; mutations in human pol eta are responsible for XPV","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002827","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR419W"}


id: YDR420W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HKR1","product":"Mucin family member that functions as an osmosensor in the HOG pathway; large, highly glycosylated protein that functions redundantly with Msb2p in Sho1p-mediated osmostresss induction of the HOG signaling pathway; cytoplasmic domain interacts with Ahk1p a scaffold protein that prevents cross talk with the Kss1p MAPK of the filamentous growth pathway; mutant displays defects in beta-1,3 glucan synthesis and bud site selection","secondary_identifier":"SGD:S000002828","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR420W"}


id: YDR421W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ARO80","product":"Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids","secondary_identifier":"SGD:S000002829","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR421W"}


id: YDR422C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SIP1","product":"One of three alternate beta-subunits of the Snf1p kinase complex; may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions","secondary_identifier":"SGD:S000002830","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR422C"}


id: YDR423C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CAD1","product":"AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002831","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR423C"}


id: YDR424C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01662":null,"YDR424C":null},"has_protein_features":false,"name":"DYN2","ortholog_annotations":[{"gene_uniquename":"YDR424C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01662","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic light chain dynein, microtubule motor protein; required for intracellular transport and cell division; involved in mitotic spindle positioning; forms complex with dynein intermediate chain Pac11p that promotes Dyn1p homodimerization, potentiates motor processivity; Dyn2p-Pac11p complex important for interaction of dynein motor complex with dynactin complex; acts as molecular glue to dimerize, stabilize Nup82-Nsp1-Nup159 complex module of cytoplasmic pore filaments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002832","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR424C"}


id: YDR425W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02852":null,"SJAG_04219":null,"YDR425W":null},"has_protein_features":false,"name":"SNX41","ortholog_annotations":[{"gene_uniquename":"YDR425W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02852","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR425W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04219","reference_uniquename":"PMID:26896847"}],"product":"Sorting nexin; involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002833","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR425W"}


id: YDR426C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41","secondary_identifier":"SGD:S000002834","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR426C"}


id: YDR427W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03408":null,"YDR427W":null},"has_protein_features":false,"name":"RPN9","ortholog_annotations":[{"gene_uniquename":"YDR427W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03408","reference_uniquename":"PMID:29761456"}],"product":"Non-ATPase regulatory subunit of the 26S proteasome; similar to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002835","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR427W"}


id: YDR428C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BNA7","product":"Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine","secondary_identifier":"SGD:S000002836","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR428C"}


id: YDR429C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03472":null,"YDR429C":null},"has_protein_features":false,"name":"TIF35","ortholog_annotations":[{"gene_uniquename":"YDR429C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03472","reference_uniquename":"PMID:29761456"}],"product":"eIF3g subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation; eIF3 is also involved in programmed stop codon readthrough","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002837","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR429C"}


id: YDR430C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04533":null,"YDR430C":null},"has_protein_features":false,"name":"CYM1","ortholog_annotations":[{"gene_uniquename":"YDR430C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04533","reference_uniquename":"PMID:29761456"}],"product":"Lysine-specific metalloprotease of the pitrilysin family; metalloprotease of the intermembrane space; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology; mutation in human homolog PITRM1 is implicated in autosomal recessive spinocerebellar ataxias (ARCA)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002838","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR430C"}


id: YDR431W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002839","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR431W"}


id: YDR432W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00425":null,"YDR432W":null},"has_protein_features":false,"name":"NPL3","ortholog_annotations":[{"gene_uniquename":"YDR432W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00425","reference_uniquename":"PMID:29761456"}],"product":"RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; represses translation initiation by binding eIF4G; required for pre-mRNA splicing; interacts with E3 ubiquitin ligase Bre1p, linking histone ubiquitination to mRNA processing; may have role in telomere maintenance; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in cytoplasm; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002840","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR432W"}


id: YDR433W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002841","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR433W"}


id: YDR434W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05278":null,"YDR434W":null},"has_protein_features":false,"name":"GPI17","ortholog_annotations":[{"gene_uniquename":"YDR434W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05278","reference_uniquename":"PMID:29761456"}],"product":"Transmembrane protein; subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002842","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR434W"}


id: YDR435C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02660":null,"YDR435C":null},"has_protein_features":false,"name":"PPM1","ortholog_annotations":[{"gene_uniquename":"YDR435C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02660","reference_uniquename":"PMID:29761456"}],"product":"Carboxyl methyltransferase; methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits; required for methionine to inhibit autophagy and promote growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002843","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR435C"}


id: YDR436W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04426":null,"YDR436W":null},"has_protein_features":false,"name":"PPZ2","ortholog_annotations":[{"gene_uniquename":"YDR436W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04426","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002844","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR436W"}


id: YDR437W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02913":null,"YDR437W":null},"has_protein_features":false,"name":"GPI19","ortholog_annotations":[{"gene_uniquename":"YDR437W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02913","reference_uniquename":"PMID:29761456"}],"product":"Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis; shares similarity with mammalian PIG-P","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002845","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR437W"}


id: YDR438W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03138":null,"YDR438W":null},"has_protein_features":false,"name":"THI74","ortholog_annotations":[{"gene_uniquename":"YDR438W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03138","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication; shows sequence homology to human gene SLC35F3, a thiamine transporter implicated in hypertension","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002846","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR438W"}


id: YDR439W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00646":null,"YDR439W":null},"has_protein_features":false,"name":"LRS4","ortholog_annotations":[{"gene_uniquename":"YDR439W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00646","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein that forms a complex with Csm1p; and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002847","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR439W"}


id: YDR440W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DOT1","product":"Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response; single DOT1 gene produces two Dot1p isoforms from alternative translation start sites as a result of leaky scanning by the ribosome","secondary_identifier":"SGD:S000002848","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR440W"}


id: YDR441C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01859":null,"YDR441C":null},"has_protein_features":false,"name":"APT2","ortholog_annotations":[{"gene_uniquename":"YDR441C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01859","reference_uniquename":"PMID:29761456"}],"product":"Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002849","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR441C"}


id: YDR442W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002850","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR442W"}


id: YDR443C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01778":null,"YDR443C":null},"has_protein_features":false,"name":"SSN2","ortholog_annotations":[{"gene_uniquename":"YDR443C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01778","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002851","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR443C"}


id: YDR444W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04105":null,"SJAG_04973":null,"YDR444W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR444W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04105","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR444W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04973","reference_uniquename":"PMID:29761456"}],"product":"Putative hydrolase acting on ester bonds","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002852","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR444W"}


id: YDR445C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002853","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR445C"}


id: YDR446W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ECM11","product":"Meiosis-specific protein; component of the Synaptonemal Complex (SC) along with Gmc2p; required for efficient crossover formation and for the efficient loading of the SC transverse filament protein, Zip1p; is SUMOlytaed in a Gmc2p manner, and SUMOylation is required for its function in meiosis; GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure","secondary_identifier":"SGD:S000002854","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR446W"}


id: YDR447C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04168":null,"SJAG_04204":null,"YDR447C":null},"has_protein_features":false,"name":"RPS17B","ortholog_annotations":[{"gene_uniquename":"YDR447C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04168","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR447C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04204","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002855","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR447C"}


id: YDR448W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04205":null,"YDR448W":null},"has_protein_features":false,"name":"ADA2","ortholog_annotations":[{"gene_uniquename":"YDR448W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04205","reference_uniquename":"PMID:29761456"}],"product":"Transcription coactivator; component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002856","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR448W"}


id: YDR449C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04069":null,"YDR449C":null},"has_protein_features":false,"name":"UTP6","ortholog_annotations":[{"gene_uniquename":"YDR449C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04069","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002857","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR449C"}


id: YDR450W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02861":null,"SJAG_04188":null,"YDR450W":null},"has_protein_features":false,"name":"RPS18A","ortholog_annotations":[{"gene_uniquename":"YDR450W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02861","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR450W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04188","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002858","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR450W"}


id: YDR451C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01157":null,"YDR451C":null},"has_protein_features":false,"name":"YHP1","ortholog_annotations":[{"gene_uniquename":"YDR451C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01157","reference_uniquename":"PMID:29761456"}],"product":"Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002859","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR451C"}


id: YDR452W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00570":null,"YDR452W":null},"has_protein_features":false,"name":"PPN1","ortholog_annotations":[{"gene_uniquename":"YDR452W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00570","reference_uniquename":"PMID:29761456"}],"product":"Dual endo- and exopolyphosphatase with a role in phosphate metabolism; acts as both an endopolyphosphatase cleaving long chains of polyphosphate distributively to generate shorter polymer chains and as an exopolyphosphatase catalyzing the hydrolysis of terminal phosphate from polyphosphate; localizes to the vacuole, nucleus and cytosol; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002860","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR452W"}


id: YDR453C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01199":null,"YDR453C":null},"has_protein_features":false,"name":"TSA2","ortholog_annotations":[{"gene_uniquename":"YDR453C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01199","reference_uniquename":"PMID:29761456"}],"product":"Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress; TSA2 has a paralog, TSA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002861","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR453C"}


id: YDR454C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04849":null,"YDR454C":null},"has_protein_features":false,"name":"GUK1","ortholog_annotations":[{"gene_uniquename":"YDR454C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04849","reference_uniquename":"PMID:29761456"}],"product":"Guanylate kinase; converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002862","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR454C"}


id: YDR455C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W","secondary_identifier":"SGD:S000002863","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR455C"}


id: YDR456W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04616":null,"YDR456W":null},"has_protein_features":false,"name":"NHX1","ortholog_annotations":[{"gene_uniquename":"YDR456W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04616","reference_uniquename":"PMID:29761456"}],"product":"Na+/H+ and K+/H+ exchanger; required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion; ortholog of human NHE9, which is linked to autism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002864","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR456W"}


id: YDR457W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02371":null,"YDR457W":null},"has_protein_features":false,"name":"TOM1","ortholog_annotations":[{"gene_uniquename":"YDR457W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02371","reference_uniquename":"PMID:29761456"}],"product":"E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002865","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR457W"}


id: YDR458C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01745":null,"SJAG_03449":null,"YDR458C":null},"has_protein_features":false,"name":"HEH2","ortholog_annotations":[{"gene_uniquename":"YDR458C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01745","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR458C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03449","reference_uniquename":"PMID:29761456"}],"product":"Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle; HEH2 has a paralog, SRC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002866","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR458C"}


id: YDR459C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01299":null,"YDR459C":null},"has_protein_features":false,"name":"PFA5","ortholog_annotations":[{"gene_uniquename":"YDR459C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01299","reference_uniquename":"PMID:29761456"}],"product":"Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002867","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR459C"}


id: YDR460W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03618":null,"YDR460W":null},"has_protein_features":false,"name":"TFB3","ortholog_annotations":[{"gene_uniquename":"YDR460W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03618","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002868","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR460W"}


id: YDR461C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CMI8","product":"Putative cytosolic protein of unknown function","secondary_identifier":"SGD:S000087209","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR461C-A"}


id: YDR461W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MFA1","product":"Mating pheromone a-factor; made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2","secondary_identifier":"SGD:S000002869","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR461W"}


id: YDR462W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04493":null,"YDR462W":null},"has_protein_features":false,"name":"MRPL28","ortholog_annotations":[{"gene_uniquename":"YDR462W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04493","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002870","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR462W"}


id: YDR463W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"STP1","product":"Transcription factor; contains a N-terminal regulatory motif (RI) that acts as a cytoplasmic retention determinant and as an Asi dependent degron in the nucleus; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002871","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR463W"}


id: YDR464C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028614","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR464C-A"}


id: YDR464W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04086":null,"YDR464W":null},"has_protein_features":false,"name":"SPP41","ortholog_annotations":[{"gene_uniquename":"YDR464W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04086","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; involved in negative regulation of expression of spliceosome components PRP4 and PRP3; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002872","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR464W"}


id: YDR465C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02271":null,"YDR465C":null},"has_protein_features":false,"name":"RMT2","ortholog_annotations":[{"gene_uniquename":"YDR465C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02271","reference_uniquename":"PMID:29761456"}],"product":"Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002873","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR465C"}


id: YDR466W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02468":null,"SJAG_05290":null,"YDR466W":null},"has_protein_features":false,"name":"PKH3","ortholog_annotations":[{"gene_uniquename":"YDR466W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02468","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR466W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05290","reference_uniquename":"PMID:26896847"}],"product":"Protein kinase with similarity to mammalian PDK1 and yeast Pkh1p/Phk2p; yeast Pkh1p and Pkh2p are two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000002874","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR466W"}


id: YDR467C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002875","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR467C"}


id: YDR468C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00171":null,"YDR468C":null},"has_protein_features":false,"name":"TLG1","ortholog_annotations":[{"gene_uniquename":"YDR468C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00171","reference_uniquename":"PMID:29761456"}],"product":"Essential t-SNARE that mediates fusion of vesicles with the late Golgi; forms a complex with Tlg2p and Vti1p; mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002876","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR468C"}


id: YDR469W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_07011":null,"YDR469W":null},"has_protein_features":false,"name":"SDC1","ortholog_annotations":[{"gene_uniquename":"YDR469W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07011","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the COMPASS (Set1C) complex; COMPASS methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002877","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR469W"}


id: YDR470C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01357":null,"YDR470C":null},"has_protein_features":false,"name":"UGO1","ortholog_annotations":[{"gene_uniquename":"YDR470C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01357","reference_uniquename":"PMID:29761456"}],"product":"Outer membrane component of the mitochondrial fusion machinery; binds to Fzo1p and Mgm1p to link these two GTPases during mitochondrial fusion; involved in fusion of both the outer and inner membranes; facilitates dimerization of Fzo1p during fusion; import into the outer membrane is mediated by Tom70p and Mim1p; has similarity to carrier proteins but likely not a transporter; similar to human SLC25A46 implicated in optic atroprophy spectrum disorder and Leigh syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002878","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR470C"}


id: YDR471W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01588":null,"SJAG_02802":null,"YDR471W":null},"has_protein_features":false,"name":"RPL27B","ortholog_annotations":[{"gene_uniquename":"YDR471W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01588","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR471W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02802","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002879","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR471W"}


id: YDR472W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02655":null,"YDR472W":null},"has_protein_features":false,"name":"TRS31","ortholog_annotations":[{"gene_uniquename":"YDR472W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02655","reference_uniquename":"PMID:29761456"}],"product":"Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002880","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR472W"}


id: YDR473C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01634":null,"YDR473C":null},"has_protein_features":false,"name":"PRP3","ortholog_annotations":[{"gene_uniquename":"YDR473C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01634","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor; component of the U4/U6-U5 snRNP complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002881","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR473C"}


id: YDR474C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YDR474C was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YDR475C","secondary_identifier":"SGD:S000002882","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR474C"}


id: YDR475C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"JIP4","product":"Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence; JIP4 has a paralog, YOR019W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002883","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR475C"}


id: YDR476C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene","secondary_identifier":"SGD:S000002884","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR476C"}


id: YDR477W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03501":null,"YDR477W":null},"has_protein_features":false,"name":"SNF1","ortholog_annotations":[{"gene_uniquename":"YDR477W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03501","reference_uniquename":"PMID:29761456"}],"product":"AMP-activated S/T protein kinase; complexes with Snf4p and a Sip1p/Sip2p/Gal83p family member; required for glucose-repressed gene transcription, heat shock, sporulation, and peroxisome biogenesis; active form involved in mitotic spindle alignment in non-limiting glucose; regulates Hxk2p nucleocytoplasmic shuttling; regulates filamentous growth and acts as a non-canonical GEF-activating Arf3p during invasive growth; sumoylation inhibits Snf1p, targeting it for Ub-ligase mediated destruction","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002885","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR477W"}


id: YDR478W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02547":null,"YDR478W":null},"has_protein_features":false,"name":"SNM1","ortholog_annotations":[{"gene_uniquename":"YDR478W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02547","reference_uniquename":"PMID:29761456"}],"product":"Ribonuclease MRP complex subunit; ribonuclease (RNase) MRP cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002886","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR478W"}


id: YDR479C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03493":null,"YDR479C":null},"has_protein_features":false,"name":"PEX29","ortholog_annotations":[{"gene_uniquename":"YDR479C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03493","reference_uniquename":"PMID:29761456"}],"product":"ER-resident protein involved in peroxisomal biogenesis; ER-localized protein that associates with peroxisomes; interacts with Pex30p and reticulons Rtn1p and Yop1p to regulate peroxisome biogenesis from the ER; role in peroxisomal-destined vesicular flow from the ER; regulates peroxisomal size, number and distribution; Pex28p and Pex29p may act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002887","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR479C"}


id: YDR480W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DIG2","product":"MAP kinase-responsive inhibitor of the Ste12p transcription factor; involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p; DIG2 has a paralog, DIG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002888","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR480W"}


id: YDR481C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02853":null,"YDR481C":null},"has_protein_features":false,"name":"PHO8","ortholog_annotations":[{"gene_uniquename":"YDR481C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02853","reference_uniquename":"PMID:29761456"}],"product":"Repressible vacuolar alkaline phosphatase; controls polyphosphate content; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002889","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR481C"}


id: YDR482C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05349":null,"YDR482C":null},"has_protein_features":false,"name":"CWC21","ortholog_annotations":[{"gene_uniquename":"YDR482C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05349","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002890","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR482C"}


id: YDR483W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"YDR483W":null},"has_protein_features":false,"name":"KRE2","ortholog_annotations":[{"gene_uniquename":"YDR483W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR483W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR483W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"}],"product":"Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002891","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR483W"}


id: YDR484W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02811":null,"YDR484W":null},"has_protein_features":false,"name":"VPS52","ortholog_annotations":[{"gene_uniquename":"YDR484W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02811","reference_uniquename":"PMID:29761456"}],"product":"Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; involved in localization of actin and chitin; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002892","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR484W"}


id: YDR485C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04596":null,"YDR485C":null},"has_protein_features":false,"name":"VPS72","ortholog_annotations":[{"gene_uniquename":"YDR485C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04596","reference_uniquename":"PMID:29761456"}],"product":"Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; may function as a lock that prevents removal of H2AZ from nucleosomes; required for vacuolar protein sorting","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002893","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR485C"}


id: YDR486C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04643":null,"YDR486C":null},"has_protein_features":false,"name":"VPS60","ortholog_annotations":[{"gene_uniquename":"YDR486C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04643","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in late endosome to vacuole transport; cytoplasmic and vacuolar membrane protein; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002894","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR486C"}


id: YDR487C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00480":null,"YDR487C":null},"has_protein_features":false,"name":"RIB3","ortholog_annotations":[{"gene_uniquename":"YDR487C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00480","reference_uniquename":"PMID:29761456"}],"product":"3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase); required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002895","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR487C"}


id: YDR488C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAC11","product":"Dynein intermediate chain, microtubule motor protein; required for intracellular transport and cell division; acts in cytoplasmic dynein pathway; forms complex with dynein light chain Dyn2p that promotes Dyn1p homodimerization and potentiates motor processivity; Dyn2p-Pac11p complex is also important for interaction of dynein motor complex with dynactin complex; forms cortical cytoplasmic microtubule capture site with Num1p; essential in the absence of CIN8","secondary_identifier":"SGD:S000002896","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR488C"}


id: YDR489W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01624":null,"YDR489W":null},"has_protein_features":false,"name":"SLD5","ortholog_annotations":[{"gene_uniquename":"YDR489W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01624","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002897","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR489W"}


id: YDR490C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02468":null,"SJAG_05290":null,"YDR490C":null},"has_protein_features":false,"name":"PKH1","ortholog_annotations":[{"gene_uniquename":"YDR490C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02468","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR490C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05290","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ypk2p, components of signaling cascade required for maintenance of cell wall integrity; contains a PH-like domain; redundant with Pkh2p; PKH1 has a paralog, PKH2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002898","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR490C"}


id: YDR491C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002899","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR491C"}


id: YDR492W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02847":null,"YDR492W":null},"has_protein_features":false,"name":"IZH1","ortholog_annotations":[{"gene_uniquename":"YDR492W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02847","reference_uniquename":"PMID:29761456"}],"product":"Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; IZH1 has a paralog, IZH4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002900","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR492W"}


id: YDR493W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03099":null,"YDR493W":null},"has_protein_features":false,"name":"MZM1","ortholog_annotations":[{"gene_uniquename":"YDR493W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03099","reference_uniquename":"PMID:29761456"}],"product":"Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; member of the LYR protein family; human LYRM7 is a functional ortholog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002901","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR493W"}


id: YDR494W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RSM28","product":"Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation","secondary_identifier":"SGD:S000002902","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR494W"}


id: YDR495C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02315":null,"YDR495C":null},"has_protein_features":false,"name":"VPS3","ortholog_annotations":[{"gene_uniquename":"YDR495C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02315","reference_uniquename":"PMID:29761456"}],"product":"Component of CORVET membrane tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002903","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR495C"}


id: YDR496C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01813":null,"YDR496C":null},"has_protein_features":false,"name":"PUF6","ortholog_annotations":[{"gene_uniquename":"YDR496C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01813","reference_uniquename":"PMID:29761456"}],"product":"Pumilio-homology domain protein; binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; co-sediments with the 60S ribosomal subunit and is required for its biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002904","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR496C"}


id: YDR497C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03595":null,"SJAG_04506":null,"YDR497C":null},"has_protein_features":false,"name":"ITR1","ortholog_annotations":[{"gene_uniquename":"YDR497C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03595","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR497C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04506","reference_uniquename":"PMID:29761456"}],"product":"Myo-inositol transporter; member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress; ITR1 has a paralog, ITR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002905","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR497C"}


id: YDR498C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02204":null,"YDR498C":null},"has_protein_features":false,"name":"SEC20","ortholog_annotations":[{"gene_uniquename":"YDR498C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02204","reference_uniquename":"PMID:29761456"}],"product":"Membrane glycoprotein v-SNARE; involved in retrograde transport from the Golgi to the endoplasmic reticulum (ER); required for N- and O-glycosylation in the Golgi but not in the ER and for efficient nuclear fusion during mating; mediates Sey1p-independent homotypic ER fusion; interacts with the Dsl1p complex through Tip20p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002906","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR498C"}


id: YDR499W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00429":null,"YDR499W":null},"has_protein_features":false,"name":"LCD1","ortholog_annotations":[{"gene_uniquename":"YDR499W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00429","reference_uniquename":"PMID:29761456"}],"product":"Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p and contributes to its activation; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002907","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR499W"}


id: YDR500C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01194":null,"SJAG_03326":null,"YDR500C":null},"has_protein_features":false,"name":"RPL37B","ortholog_annotations":[{"gene_uniquename":"YDR500C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01194","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR500C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03326","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L37B; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002908","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR500C"}


id: YDR501W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04512":null,"YDR501W":null},"has_protein_features":false,"name":"PLM2","ortholog_annotations":[{"gene_uniquename":"YDR501W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04512","reference_uniquename":"PMID:29761456"}],"product":"Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002909","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR501W"}


id: YDR502C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03659":null,"YDR502C":null},"has_protein_features":false,"name":"SAM2","ortholog_annotations":[{"gene_uniquename":"YDR502C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03659","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002910","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR502C"}


id: YDR503C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LPP1","product":"Lipid phosphate phosphatase; catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA","secondary_identifier":"SGD:S000002911","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR503C"}


id: YDR504C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPG3","product":"Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum","secondary_identifier":"SGD:S000002912","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR504C"}


id: YDR505C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04686":null,"YDR505C":null},"has_protein_features":false,"name":"PSP1","ortholog_annotations":[{"gene_uniquename":"YDR505C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04686","reference_uniquename":"PMID:29761456"}],"product":"Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; capable of forming the prion [PSP1+]; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002913","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR505C"}


id: YDR506C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04677":null,"YDR506C":null},"has_protein_features":false,"name":"GMC1","ortholog_annotations":[{"gene_uniquename":"YDR506C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04677","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002914","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR506C"}


id: YDR507C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03602":null,"SJAG_04486":null,"YDR507C":null},"has_protein_features":false,"name":"GIN4","ortholog_annotations":[{"gene_uniquename":"YDR507C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03602","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR507C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04486","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; negatively regulates Fpk1p kinase that stimulates phospholipid flippases Dnf1p and Dnf2p; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002915","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR507C"}


id: YDR508C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YDR508C":null},"has_protein_features":false,"name":"GNP1","ortholog_annotations":[{"gene_uniquename":"YDR508C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR508C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR508C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR508C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR508C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR508C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR508C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR508C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR508C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"Broad specificity amino acid permease; high-affinity glutamine permease; major serine permease with minor contributions from paralog Agp1p; role in serine uptake impacts cellular sphingolipid homeostasis; also transports Leu, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002916","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR508C"}


id: YDR509W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002917","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR509W"}


id: YDR510C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028615","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR510C-A"}


id: YDR510W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03843":null,"YDR510W":null},"has_protein_features":false,"name":"SMT3","ortholog_annotations":[{"gene_uniquename":"YDR510W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03843","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-like protein of the SUMO family; conjugated to lysine residues of target proteins; associates with transcriptionally active genes; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; human homolog SUMO1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002918","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR510W"}


id: YDR511W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03574":null,"YDR511W":null},"has_protein_features":false,"name":"SDH7","ortholog_annotations":[{"gene_uniquename":"YDR511W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03574","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; localized to the mitochondrial intermembrane space; required for acetate utilization and gluconeogenesis; mutation in Drosophila ortholog SDHAF3 causes reduced succinate dehydrogenase activity and neuronal and muscular dysfunction; member of the LYR protein family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002919","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR511W"}


id: YDR512C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02387":null,"YDR512C":null},"has_protein_features":false,"name":"EMI1","ortholog_annotations":[{"gene_uniquename":"YDR512C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02387","reference_uniquename":"PMID:29761456"}],"product":"Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs; deletion affects mitochondrial morphology","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002920","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR512C"}


id: YDR513W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01292":null,"SJAG_04632":null,"YDR513W":null},"has_protein_features":false,"name":"GRX2","ortholog_annotations":[{"gene_uniquename":"YDR513W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01292","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR513W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04632","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has two in-frame start codons resulting in a shorter isoform that is retained in the cytosol and a longer form translocated to the mitochondrial matrix; GRX2 has a paralog, GRX1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002921","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR513W"}


id: YDR514C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03874":null,"YDR514C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR514C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03874","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002922","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR514C"}


id: YDR515W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01026":null,"YDR515W":null},"has_protein_features":false,"name":"SLF1","ortholog_annotations":[{"gene_uniquename":"YDR515W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01026","reference_uniquename":"PMID:29761456"}],"product":"RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002923","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR515W"}


id: YDR516C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04495":null,"YDR516C":null},"has_protein_features":false,"name":"EMI2","ortholog_annotations":[{"gene_uniquename":"YDR516C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04495","reference_uniquename":"PMID:29761456"}],"product":"Hexokinase expressed during growth with low glucose levels; induced on non-fermentable carbon sources; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; protein abundance increases in response to DNA replication stress; EMI2 has a paralog, GLK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002924","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR516C"}


id: YDR517W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01003":null,"YDR517W":null},"has_protein_features":false,"name":"GRH1","ortholog_annotations":[{"gene_uniquename":"YDR517W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01003","reference_uniquename":"PMID:29761456"}],"product":"Acetylated cis-Golgi protein, homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; required for unconventional protein secretion (UPS) of Acb1p in response to starvation; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002925","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR517W"}


id: YDR518W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00288":null,"YDR518W":null},"has_protein_features":false,"name":"EUG1","ortholog_annotations":[{"gene_uniquename":"YDR518W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00288","reference_uniquename":"PMID:29761456"}],"product":"Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002926","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR518W"}


id: YDR519W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FPR2","product":"Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress; mutation is functionally complemented by human FKBP2","secondary_identifier":"SGD:S000002927","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR519W"}


id: YDR520C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04712":null,"YDR520C":null},"has_protein_features":false,"name":"URC2","ortholog_annotations":[{"gene_uniquename":"YDR520C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04712","reference_uniquename":"PMID:29761456"}],"product":"Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002928","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR520C"}


id: YDR521W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol","secondary_identifier":"SGD:S000002929","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR521W"}


id: YDR522C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00340":null,"SJAG_03483":null,"YDR522C":null},"has_protein_features":false,"name":"SPS2","ortholog_annotations":[{"gene_uniquename":"YDR522C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00340","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR522C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03483","reference_uniquename":"PMID:29761456"}],"product":"Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002930","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR522C"}


id: YDR523C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02022":null,"YDR523C":null},"has_protein_features":false,"name":"SPS1","ortholog_annotations":[{"gene_uniquename":"YDR523C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02022","reference_uniquename":"PMID:29761456"}],"product":"STE20-family GCKIII protein kinase; required for prospore membrane closure, efficient spore packaging, and localization of enzymes involved in spore wall synthesis; component of a non-canonical Hippo pathway with Cdc15p involved in spindle disassembly and sustained release of Cdc14p during anaphase II; forms a complex with Cdc15p;  phosphorylation requires Cdc15p; required for Ssp1p phosphorylation and turnover; interacts with 14-3-3 proteins; expressed in late meiosis; nuclear and cytoplasmic","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002931","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR523C"}


id: YDR524C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01600":null,"SJAG_02277":null,"YDR524C":null},"has_protein_features":false,"name":"AGE1","ortholog_annotations":[{"gene_uniquename":"YDR524C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01600","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR524C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02277","reference_uniquename":"PMID:26896847"}],"product":"ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002932","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR524C"}


id: YDR524C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028616","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR524C-A"}


id: YDR524C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication","secondary_identifier":"SGD:S000028739","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR524C-B"}


id: YDR524W-C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin","secondary_identifier":"SGD:S000028740","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR524W-C"}


id: YDR525W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"API2","product":"Putative protein of unknown function; conserved among S. cerevisiae strains; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology","secondary_identifier":"SGD:S000002933","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR525W"}


id: YDR525W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNA2","product":"Protein of unknown function; has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern","secondary_identifier":"SGD:S000007236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR525W-A"}


id: YDR526C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002934","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR526C"}


id: YDR527W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04559":null,"YDR527W":null},"has_protein_features":false,"name":"RBA50","ortholog_annotations":[{"gene_uniquename":"YDR527W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04559","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002935","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR527W"}


id: YDR528W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HLR1","product":"Protein involved in regulation of cell wall composition and integrity; also involved in cell wall response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; HLR1 has a paralog, LRE1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002936","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR528W"}


id: YDR529C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03490":null,"YDR529C":null},"has_protein_features":false,"name":"QCR7","ortholog_annotations":[{"gene_uniquename":"YDR529C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03490","reference_uniquename":"PMID:29761456"}],"product":"Subunit 7 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002937","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR529C"}


id: YDR530C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"APA2","product":"Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002938","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR530C"}


id: YDR531W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00427":null,"YDR531W":null},"has_protein_features":false,"name":"CAB1","ortholog_annotations":[{"gene_uniquename":"YDR531W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00427","reference_uniquename":"PMID:29761456"}],"product":"Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase; catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002939","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR531W"}


id: YDR532C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03327":null,"YDR532C":null},"has_protein_features":false,"name":"KRE28","ortholog_annotations":[{"gene_uniquename":"YDR532C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03327","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Spc105p; modified by sumoylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002940","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR532C"}


id: YDR533C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02988":null,"SJAG_04674":null,"YDR533C":null},"has_protein_features":false,"name":"HSP31","ortholog_annotations":[{"gene_uniquename":"YDR533C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02988","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR533C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04674","reference_uniquename":"PMID:29761456"}],"product":"Methylglyoxalase that converts methylglyoxal to D-lactate; involved in oxidative stress resistance, diauxic shift, and stationary phase survival; has similarity to E. coli Hsp31 and C. albicans Glx3p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002941","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR533C"}


id: YDR534C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FIT1","product":"Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall","secondary_identifier":"SGD:S000002942","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR534C"}


id: YDR535C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene","secondary_identifier":"SGD:S000002943","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR535C"}


id: YDR536W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04905":null,"YDR536W":null},"has_protein_features":false,"name":"STL1","ortholog_annotations":[{"gene_uniquename":"YDR536W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR536W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR536W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR536W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR536W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Glycerol proton symporter of the plasma membrane; subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002944","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR536W"}


id: YDR537C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps verified ORF PAD1/YDR538W","secondary_identifier":"SGD:S000002945","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR537C"}


id: YDR538W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAD1","product":"Phenylacrylic acid decarboxylase; decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; confers resistance to cinnamic acid; overexpression of both Pad1p and Fdc1p increases cinnamic acid decarboxylase activity due to the Pad1p-catalyzed formation of a diffusible cofactor required for Fdc1p activity; contains mRNA binding activity; homolog of E. coli UbiX","secondary_identifier":"SGD:S000002946","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR538W"}


id: YDR539W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FDC1","product":"Ferulic acid decarboxylase; involved in the decarboxylation of aromatic carboxylic acids such as phenylacrylic (cinnamic) acid, ferulic acid and coumaric acid and formation of the corresponding vinyl derivatives; overexpression of both Pad1p and Fdc1p increases decarboxylase activity due to the Pad1p-catalyzed formation of a diffusible cofactor required for Fdc1p activity; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm in an HTP study","secondary_identifier":"SGD:S000002947","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR539W"}


id: YDR540C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IRC4","product":"Protein similar to bacterial secreted DfsB proteins; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus","secondary_identifier":"SGD:S000002948","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR540C"}


id: YDR541C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02960":null,"YDR541C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR541C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02960","reference_uniquename":"PMID:29761456"}],"product":"Aldehyde reductase; substrates include both aromatic and aliphatic aldehydes; uses NADPH as cofactor; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002949","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR541C"}


id: YDR542W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU10","product":"Protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to the vacuole; member of the seripauperin multigene family encoded mainly in subtelomeric regions","secondary_identifier":"SGD:S000002950","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR542W"}


id: YDR543C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002951","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR543C"}


id: YDR544C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002952","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR544C"}


id: YDR545C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YRF1-1/YDR545W","secondary_identifier":"SGD:S000028617","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR545C-A"}


id: YDR545W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YRF1-1","product":"Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p","secondary_identifier":"SGD:S000002953","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR545W"}


id: YEL001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IRC22","product":"Protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci","secondary_identifier":"SGD:S000000727","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL001C"}


id: YEL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01069":null,"YEL002C":null},"has_protein_features":false,"name":"WBP1","ortholog_annotations":[{"gene_uniquename":"YEL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01069","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of the oligosaccharyl transferase glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum; human homolog DDOST can complement yeast growth defect during down-regulation of yeast gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000728","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL002C"}


id: YEL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05191":null,"YEL003W":null},"has_protein_features":false,"name":"GIM4","ortholog_annotations":[{"gene_uniquename":"YEL003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05191","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the heterohexameric cochaperone prefoldin complex; complex binds specifically to cytosolic chaperonin and transfers target proteins to it","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000729","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL003W"}


id: YEL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00434":null,"YEL004W":null},"has_protein_features":false,"name":"YEA4","ortholog_annotations":[{"gene_uniquename":"YEL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00434","reference_uniquename":"PMID:29761456"}],"product":"Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter; required for cell wall chitin synthesis; localized to the ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000730","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL004W"}


id: YEL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"VAB2","product":"Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Vps21p-GFP; has potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of; Vab2p-GFP-fusion localizes to cytoplasm in punctate pattern","secondary_identifier":"SGD:S000000731","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL005C"}


id: YEL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04328":null,"YEL006W":null},"has_protein_features":false,"name":"YEA6","ortholog_annotations":[{"gene_uniquename":"YEL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04328","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial NAD+ transporter; member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog; YEA6 has a paralog, YIA6, that arose from the whole genome duplication; human NAD+ transporter MCART1/SLC25A51 functionally complements the yia6 yea6 double null mutant, and yeast YEA6 reciprocally complements defects in MCART1/SLC25A51 null cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000732","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL006W"}


id: YEL007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02921":null,"SJAG_04920":null,"YEL007W":null},"has_protein_features":false,"name":"MIT1","ortholog_annotations":[{"gene_uniquename":"YEL007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02921","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04920","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000733","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL007W"}


id: YEL008C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028618","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL008C-A"}


id: YEL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YEL008W is not an essential gene; predicted to be involved in metabolism","secondary_identifier":"SGD:S000000734","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL008W"}


id: YEL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GCN4","product":"bZIP transcriptional activator of amino acid biosynthetic genes;  activator responds to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels; contains four upstream open reading frames (uORFs) in 5' untranslated region which regulate translation","secondary_identifier":"SGD:S000000735","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL009C"}


id: YEL009C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; overlaps ORF YEL010W","secondary_identifier":"SGD:S000028741","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL009C-A"}


id: YEL010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000736","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL010W"}


id: YEL011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GLC3","product":"Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; glycogen accumulation defect of the null mutant is functionally complemented by human GBE1, which is associated with glycogen storage disease","secondary_identifier":"SGD:S000000737","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL011W"}


id: YEL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00855":null,"YEL012W":null},"has_protein_features":false,"name":"UBC8","ortholog_annotations":[{"gene_uniquename":"YEL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00855","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-conjugating enzyme that regulates gluconeogenesis; negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000738","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL012W"}


id: YEL013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00029":null,"YEL013W":null},"has_protein_features":false,"name":"VAC8","ortholog_annotations":[{"gene_uniquename":"YEL013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00029","reference_uniquename":"PMID:29761456"}],"product":"Vacuole-specific Myo2p receptor; Myo2p-Vac17p-Vac8p transport complex subunit required for vacuolar inheritance; mediates anchoring of phosphatidylinositol 3-kinase complex I (PIK3C3-C1) to autophagosome; required with Atg13p for the vesicle closure step of the cytoplasm-to-vacuole (CVT) pathway, for homotypic vacuole-vacuole fusion and for nucleus-vacuole junction formation with Nvj1p; contains 11 armadillo (ARM) repeats; myristoylated, palmitoylated, and phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000739","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL013W"}


id: YEL014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000000740","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL014C"}


id: YEL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04640":null,"YEL015W":null},"has_protein_features":false,"name":"EDC3","ortholog_annotations":[{"gene_uniquename":"YEL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04640","reference_uniquename":"PMID:29761456"}],"product":"Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; mediates decay of the RPS28B mRNA via binding to both Rps28Bp (or Rps28Ap) and the RPS28B mRNA; mediates decay of the YRA1 mRNA by a different, translation-independent mechanism; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000741","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL015W"}


id: YEL016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00705":null,"YEL016C":null},"has_protein_features":false,"name":"NPP2","ortholog_annotations":[{"gene_uniquename":"YEL016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00705","reference_uniquename":"PMID:29761456"}],"product":"Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; NPP2 has a paralog, NPP1, that arose from the whole genome duplication; npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to single mutants","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000742","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL016C"}


id: YEL017C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PMP2","product":"Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002103","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL017C-A"}


id: YEL017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GTT3","product":"Protein of unknown function may be involved in glutathione metabolism; function suggested by computational analysis of large-scale protein-protein interaction data; N- and C-terminal fusion proteins localize to the cell periphery","secondary_identifier":"SGD:S000000743","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL017W"}


id: YEL018C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF EAF5/YEL018W","secondary_identifier":"SGD:S000028742","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL018C-A"}


id: YEL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"EAF5","product":"Non-essential subunit of the NuA4 acetyltransferase complex; Esa1p-associated factor; relocalizes to the cytosol in response to hypoxia","secondary_identifier":"SGD:S000000744","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL018W"}


id: YEL019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01776":null,"YEL019C":null},"has_protein_features":false,"name":"MMS21","ortholog_annotations":[{"gene_uniquename":"YEL019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01776","reference_uniquename":"PMID:29761456"}],"product":"Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex; required for anchoring dsDNA breaks to the nuclear periphery; SMC5-SMC6 plays a key role in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; required for efficient sister chromatid cohesion; mutants are sensitive to MMS, show increased spontaneous mutation and mitotic recombination; SUMOylates and inhibits Snf1p function; supports nucleolar function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000745","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL019C"}


id: YEL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00706":null,"YEL020C":null},"has_protein_features":false,"name":"PXP1","ortholog_annotations":[{"gene_uniquename":"YEL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00706","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal matrix protein; well-conserved in fungi; contains tripartite homology domain of thiamine pyrophosphate (TPP) enzymes; targeted to peroxisomes by Pex5p; contains low sequence identity with Pdc1p; mRNA identified as translated by ribosome profiling data","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000746","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL020C"}


id: YEL020C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028544","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL020C-B"}


id: YEL020W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04208":null,"YEL020W-A":null},"has_protein_features":false,"name":"TIM9","ortholog_annotations":[{"gene_uniquename":"YEL020W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04208","reference_uniquename":"PMID:29761456"}],"product":"Essential protein of the mitochondrial intermembrane space; forms a complex with Tim10p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL020W-A"}


id: YEL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03164":null,"YEL021W":null},"has_protein_features":false,"name":"URA3","ortholog_annotations":[{"gene_uniquename":"YEL021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03164","reference_uniquename":"PMID:29761456"}],"product":"Orotidine-5'-phosphate (OMP) decarboxylase; catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000747","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL021W"}


id: YEL022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00858":null,"YEL022W":null},"has_protein_features":false,"name":"GEA2","ortholog_annotations":[{"gene_uniquename":"YEL022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00858","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000748","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL022W"}


id: YEL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene","secondary_identifier":"SGD:S000000749","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL023C"}


id: YEL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00601":null,"YEL024W":null},"has_protein_features":false,"name":"RIP1","ortholog_annotations":[{"gene_uniquename":"YEL024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00601","reference_uniquename":"PMID:29761456"}],"product":"Ubiquinol-cytochrome-c reductase; a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000750","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL024W"}


id: YEL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","secondary_identifier":"SGD:S000000751","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL025C"}


id: YEL026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03410":null,"YEL026W":null},"has_protein_features":false,"name":"SNU13","ortholog_annotations":[{"gene_uniquename":"YEL026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03410","reference_uniquename":"PMID:29761456"}],"product":"RNA binding protein; part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000752","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL026W"}


id: YEL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02782":null,"YEL027W":null},"has_protein_features":false,"name":"VMA3","ortholog_annotations":[{"gene_uniquename":"YEL027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02782","reference_uniquename":"PMID:29761456"}],"product":"Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase; dicyclohexylcarbodiimide binding subunit; required for vacuolar acidification and important for copper and iron metal ion homeostasis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000753","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL027W"}


id: YEL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YEL028W is not an essential gene","secondary_identifier":"SGD:S000000754","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL028W"}


id: YEL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00252":null,"SJAG_01383":null,"YEL029C":null},"has_protein_features":false,"name":"BUD16","ortholog_annotations":[{"gene_uniquename":"YEL029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00252","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01383","reference_uniquename":"PMID:29761456"}],"product":"Putative pyridoxal kinase; a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000755","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL029C"}


id: YEL030C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL030C-A"}


id: YEL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01615":null,"YEL030W":null},"has_protein_features":false,"name":"ECM10","ortholog_annotations":[{"gene_uniquename":"YEL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01615","reference_uniquename":"PMID:29761456"}],"product":"Heat shock protein of the Hsp70 family; localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; ECM10 has a paralog, SSC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000756","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL030W"}


id: YEL031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01435":null,"YEL031W":null},"has_protein_features":false,"name":"SPF1","ortholog_annotations":[{"gene_uniquename":"YEL031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01435","reference_uniquename":"PMID:29761456"}],"product":"P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid and sterol composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1; null mutation is complemented by human Parkinson disease-related ATP13A1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000757","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL031W"}


id: YEL032C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028620","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL032C-A"}


id: YEL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01762":null,"YEL032W":null},"has_protein_features":false,"name":"MCM3","ortholog_annotations":[{"gene_uniquename":"YEL032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01762","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000758","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL032W"}


id: YEL033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MTC7","product":"Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant","secondary_identifier":"SGD:S000000759","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL033W"}


id: YEL034C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps HYP2/YEL034W, a verified gene that encodes eiF-5A","secondary_identifier":"SGD:S000028743","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL034C-A"}


id: YEL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02189":null,"SJAG_02812":null,"YEL034W":null},"has_protein_features":false,"name":"HYP2","ortholog_annotations":[{"gene_uniquename":"YEL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02189","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02812","reference_uniquename":"PMID:29761456"}],"product":"Translation elongation factor eIF-5A; required for translation of proteins containing polyproline stretches, including Bni1p, and this leads to a requirement for mating projection formation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication; human EIF5A complements the inviability of the yeast hyp2 anb1 double null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000760","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL034W"}


id: YEL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"UTR5","product":"Protein of unknown function; originally considered essential but deletion overlapped the TATA box of neighboring essential gene HYP2, while deletion that avoids the HYP2 TATA box is viable; transcription may be regulated by Gcr1p","secondary_identifier":"SGD:S000000761","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL035C"}


id: YEL036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00816":null,"YEL036C":null},"has_protein_features":false,"name":"ANP1","ortholog_annotations":[{"gene_uniquename":"YEL036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00816","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000762","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL036C"}


id: YEL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00941":null,"YEL037C":null},"has_protein_features":false,"name":"RAD23","ortholog_annotations":[{"gene_uniquename":"YEL037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00941","reference_uniquename":"PMID:29761456"}],"product":"Protein with ubiquitin-like N terminus; subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover; Rad4p-Rad23p heterodimer binds to promoters of DNA damage response genes to repress their transcription in the absence of DNA damage","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000763","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL037C"}


id: YEL038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01404":null,"YEL038W":null},"has_protein_features":false,"name":"UTR4","ortholog_annotations":[{"gene_uniquename":"YEL038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01404","reference_uniquename":"PMID:29761456"}],"product":"Protein with sequence similarity to acireductone synthases; involved in methionine salvage; found in both the cytoplasm and nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000764","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL038W"}


id: YEL039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02744":null,"YEL039C":null},"has_protein_features":false,"name":"CYC7","ortholog_annotations":[{"gene_uniquename":"YEL039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02744","reference_uniquename":"PMID:29761456"}],"product":"Cytochrome c isoform 2, expressed under hypoxic conditions; also known as iso-2-cytochrome c; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000765","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL039C"}


id: YEL040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04327":null,"YEL040W":null},"has_protein_features":false,"name":"UTR2","ortholog_annotations":[{"gene_uniquename":"YEL040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04327","reference_uniquename":"PMID:29761456"}],"product":"Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000766","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL040W"}


id: YEL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01566":null,"SJAG_01582":null,"YEL041W":null},"has_protein_features":false,"name":"YEF1","ortholog_annotations":[{"gene_uniquename":"YEL041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01566","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01582","reference_uniquename":"PMID:29761456"}],"product":"ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000767","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL041W"}


id: YEL042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01595":null,"YEL042W":null},"has_protein_features":false,"name":"GDA1","ortholog_annotations":[{"gene_uniquename":"YEL042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01595","reference_uniquename":"PMID:29761456"}],"product":"Guanosine diphosphatase located in the Golgi; involved in the transport of GDP-mannose into the Golgi lumen, converting GDP to GMP after mannose is transferred to substrates; null mutants are defective in sporulation and pre-meiotic S phase entry; orthologous to human ENTPD6, a meiosis-associated non-obstructive azoospermia (NOA) related gene identified in GWAS studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000768","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL042W"}


id: YEL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GTA1","product":"Protein of unknown function; proposed role in Golgi vesicle trafficking based on phenotypic profile, presence of a coiled-coil domain often associated with vesicle tethering proteins, and interaction profile process enrichment; may interact with ribosomes, based on co-purification studies; localizes to the ER and cell periphery in HTP studies; contains fibronectin type III domain fold","secondary_identifier":"SGD:S000000769","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL043W"}


id: YEL044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02303":null,"YEL044W":null},"has_protein_features":false,"name":"IES6","ortholog_annotations":[{"gene_uniquename":"YEL044W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02303","reference_uniquename":"PMID:29761456"}],"product":"Component of the INO80 chromatin remodeling complex; critical for INO80 function; involved in regulation of chromosome segregation and maintenance of normal centromeric chromatin structure; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000770","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL044W"}


id: YEL045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress","secondary_identifier":"SGD:S000000771","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL045C"}


id: YEL046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02450":null,"YEL046C":null},"has_protein_features":false,"name":"GLY1","ortholog_annotations":[{"gene_uniquename":"YEL046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02450","reference_uniquename":"PMID:29761456"}],"product":"Threonine aldolase; catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000772","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL046C"}


id: YEL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00203":null,"YEL047C":null},"has_protein_features":false,"name":"FRD1","ortholog_annotations":[{"gene_uniquename":"YEL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00203","reference_uniquename":"PMID:29761456"}],"product":"Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000773","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL047C"}


id: YEL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04618":null,"YEL048C":null},"has_protein_features":false,"name":"TCA17","ortholog_annotations":[{"gene_uniquename":"YEL048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04618","reference_uniquename":"PMID:29761456"}],"product":"Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; promotes association of TRAPPII-specific subunits with the TRAPP core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000774","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL048C"}


id: YEL049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU2","product":"Member of the seripauperin multigene family; encoded mainly in subtelomeric region; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme","secondary_identifier":"SGD:S000000775","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL049W"}


id: YEL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01829":null,"YEL050C":null},"has_protein_features":false,"name":"RML2","ortholog_annotations":[{"gene_uniquename":"YEL050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01829","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit (L2); has similarity to E. coli L2 ribosomal protein; mutant allele (fat21) causes inability to utilize oleate, and induce oleic acid oxidation; may interfere with activity of the Adr1p transcription factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000776","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL050C"}


id: YEL050W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028545","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL050W-A"}


id: YEL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01817":null,"YEL051W":null},"has_protein_features":false,"name":"VMA8","ortholog_annotations":[{"gene_uniquename":"YEL051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01817","reference_uniquename":"PMID:29761456"}],"product":"Subunit D of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000777","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL051W"}


id: YEL052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04154":null,"YEL052W":null},"has_protein_features":false,"name":"AFG1","ortholog_annotations":[{"gene_uniquename":"YEL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04154","reference_uniquename":"PMID:29761456"}],"product":"Protein that may act as a chaperone for cytochrome c oxidase subunits; conserved protein; may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000778","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL052W"}


id: YEL053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03215":null,"YEL053C":null},"has_protein_features":false,"name":"MAK10","ortholog_annotations":[{"gene_uniquename":"YEL053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03215","reference_uniquename":"PMID:29761456"}],"product":"Non-catalytic subunit of the NatC N-terminal acetyltransferase; required for replication of dsRNA virus; expression is glucose-repressible; human NatC ortholog, Naa35, requires co-expression of the human catalytic subunit, Naa30, to functionally complement the null allele","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000779","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL053C"}


id: YEL053W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene RPL12A/YEL054C","secondary_identifier":"SGD:S000028744","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL053W-A"}


id: YEL054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02535":null,"SJAG_05248":null,"YEL054C":null},"has_protein_features":false,"name":"RPL12A","ortholog_annotations":[{"gene_uniquename":"YEL054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02535","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05248","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000780","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL054C"}


id: YEL055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05253":null,"YEL055C":null},"has_protein_features":false,"name":"POL5","ortholog_annotations":[{"gene_uniquename":"YEL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05253","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in 60S assembly and pre-40S AFs recycling; has sequence similarity to human MybBP1A and weak sequence similarity to B-type DNA polymerases; not required for chromosomal DNA replication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000781","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL055C"}


id: YEL056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02439":null,"SJAG_03867":null,"YEL056W":null},"has_protein_features":false,"name":"HAT2","ortholog_annotations":[{"gene_uniquename":"YEL056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02439","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YEL056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03867","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000782","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL056W"}


id: YEL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SDD1","product":"Protein of unknown function; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; may have a role in telomere maintenance; target of UME6 regulation","secondary_identifier":"SGD:S000000783","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL057C"}


id: YEL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00978":null,"SJAG_03723":null,"YEL058W":null},"has_protein_features":false,"name":"PCM1","ortholog_annotations":[{"gene_uniquename":"YEL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00978","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03723","reference_uniquename":"PMID:29761456"}],"product":"Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL058W"}


id: YEL059C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SOM1","product":"Subunit of the mitochondrial inner membrane peptidase (IMP); IMP is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs","secondary_identifier":"SGD:S000002954","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL059C-A"}


id: YEL059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HHY1","product":"Putative protein of unknown function; null mutant is sensitive to heat, pH disturbances, ionic stress, and various chemicals; hypersensitivity to hygromycin B indicative of defects in vacuolar trafficking","secondary_identifier":"SGD:S000000785","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL059W"}


id: YEL060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02432":null,"SJAG_04785":null,"YEL060C":null},"has_protein_features":false,"name":"PRB1","ortholog_annotations":[{"gene_uniquename":"YEL060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02432","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04785","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity; serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress; PRB1 has a paralog, YSP3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000786","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL060C"}


id: YEL061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04745":null,"YEL061C":null},"has_protein_features":false,"name":"CIN8","ortholog_annotations":[{"gene_uniquename":"YEL061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04745","reference_uniquename":"PMID:29761456"}],"product":"Bipolar kinesin motor protein; switches from minus- to plus-end-directed motility in vitro depending on conditions; involved in mitotic spindle assembly and chromosome segregation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000787","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL061C"}


id: YEL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02765":null,"YEL062W":null},"has_protein_features":false,"name":"NPR2","ortholog_annotations":[{"gene_uniquename":"YEL062W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02765","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of the SEA complex, a coatomer-related complex that associates dynamically with the vacuole; Npr2p may have a structural or regulatory role, supporting Iml1p function as a GAP for the Rag family GTPase Gtr1p, and resulting in inhibition of TORC1 signaling in response to amino acid deprivation; SEACIT is required for non-nitrogen-starvation-induced autophagy; homolog of human tumor suppressor NPRL2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000788","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL062W"}


id: YEL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CAN1","product":"Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000789","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL063C"}


id: YEL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AVT2","product":"Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters","secondary_identifier":"SGD:S000000790","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL064C"}


id: YEL065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YEL065W":null},"has_protein_features":false,"name":"SIT1","ortholog_annotations":[{"gene_uniquename":"YEL065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"Ferrioxamine B transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000791","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL065W"}


id: YEL066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03288":null,"YEL066W":null},"has_protein_features":false,"name":"HPA3","ortholog_annotations":[{"gene_uniquename":"YEL066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03288","reference_uniquename":"PMID:29761456"}],"product":"D-Amino acid N-acetyltransferase that detoxifies D-amino acids; catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; acetylates histones and polyamines, also autoacetylates","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000792","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL066W"}


id: YEL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000000793","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL067C"}


id: YEL068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum and mCherry fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000000794","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL068C"}


id: YEL069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YEL069C":null},"has_protein_features":false,"name":"HXT13","ortholog_annotations":[{"gene_uniquename":"YEL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YEL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YEL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000795","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL069C"}


id: YEL070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DSF1","product":"Mannitol dehydrogenase; deletion suppresses mutation of mpt5; DSF1 has a paralog, MAN2, that arose from a segmental duplication","secondary_identifier":"SGD:S000000796","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL070W"}


id: YEL071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03804":null,"YEL071W":null},"has_protein_features":false,"name":"DLD3","ortholog_annotations":[{"gene_uniquename":"YEL071W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03804","reference_uniquename":"PMID:29761456"}],"product":"2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase; converts D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate in the presence of FAD, with concomitant reduction of pyruvate to D-lactate; minor lactate dehydrogenase activity; component of the retrograde regulon that consists of genes whose expression are stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source; located in the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000797","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL071W"}


id: YEL072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RMD6","product":"Protein required for sporulation","secondary_identifier":"SGD:S000000798","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL072W"}


id: YEL073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline","secondary_identifier":"SGD:S000000799","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL073C"}


id: YEL074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; large scale expression analysis showed an increase in mRNA accumulation in strains mutant for exosome components","secondary_identifier":"SGD:S000000800","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL074W"}


id: YEL075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000000801","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL075C"}


id: YEL075W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002956","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL075W-A"}


id: YEL076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000000802","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL076C"}


id: YEL076C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000002955","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL076C-A"}


id: YEL077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Helicase-like protein encoded within the telomeric Y' element","secondary_identifier":"SGD:S000006409","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL077C"}


id: YEL077W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028621","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL077W-A"}


id: YER001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MNN1","product":"Alpha-1,3-mannosyltransferase; integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family","secondary_identifier":"SGD:S000000803","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER001W"}


id: YER002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01454":null,"YER002W":null},"has_protein_features":false,"name":"NOP16","ortholog_annotations":[{"gene_uniquename":"YER002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01454","reference_uniquename":"PMID:29761456"}],"product":"Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000804","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER002W"}


id: YER003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02648":null,"YER003C":null},"has_protein_features":false,"name":"PMI40","ortholog_annotations":[{"gene_uniquename":"YER003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02648","reference_uniquename":"PMID:29761456"}],"product":"Mannose-6-phosphate isomerase; catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000805","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER003C"}


id: YER004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FMP52","product":"Protein of unknown function; localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation","secondary_identifier":"SGD:S000000806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER004W"}


id: YER005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03676":null,"YER005W":null},"has_protein_features":false,"name":"YND1","ortholog_annotations":[{"gene_uniquename":"YER005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03676","reference_uniquename":"PMID:29761456"}],"product":"Apyrase with wide substrate specificity; helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER005W"}


id: YER006C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PAC2/YER007W","secondary_identifier":"SGD:S000028745","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER006C-A"}


id: YER006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04004":null,"YER006W":null},"has_protein_features":false,"name":"NUG1","ortholog_annotations":[{"gene_uniquename":"YER006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04004","reference_uniquename":"PMID:29761456"}],"product":"GTPase that associates with nuclear 60S pre-ribosomes; required for export of 60S ribosomal subunits from the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER006W"}


id: YER007C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00912":null,"YER007C-A":null},"has_protein_features":false,"name":"TMA20","ortholog_annotations":[{"gene_uniquename":"YER007C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00912","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002957","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER007C-A"}


id: YER007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02672":null,"YER007W":null},"has_protein_features":false,"name":"PAC2","ortholog_annotations":[{"gene_uniquename":"YER007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02672","reference_uniquename":"PMID:29761456"}],"product":"Microtubule effector required for tubulin heterodimer formation; binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000809","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER007W"}


id: YER008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02166":null,"YER008C":null},"has_protein_features":false,"name":"SEC3","ortholog_annotations":[{"gene_uniquename":"YER008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02166","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000810","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER008C"}


id: YER009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02425":null,"YER009W":null},"has_protein_features":false,"name":"NTF2","ortholog_annotations":[{"gene_uniquename":"YER009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02425","reference_uniquename":"PMID:29761456"}],"product":"Nuclear envelope protein; interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER009W"}


id: YER010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Bifunctional HMG aldolase/oxaloacetate decarboxylase; requires divalent metal ions for activity; competitively inhibited by oxalate; forms a ring-shaped homotrimer; similar to members of the prokaryotic RraA family of class II (divalent metal ion dependent) pyruvate aldolases from the meta cleavage pathways of protocatechuate and gallate","secondary_identifier":"SGD:S000000812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER010C"}


id: YER011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TIR1","product":"Cell wall mannoprotein; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking; member of the Srp1p/Tip1p family of serine-alanine-rich proteins","secondary_identifier":"SGD:S000000813","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER011W"}


id: YER012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04888":null,"YER012W":null},"has_protein_features":false,"name":"PRE1","ortholog_annotations":[{"gene_uniquename":"YER012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04888","reference_uniquename":"PMID:29761456"}],"product":"Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000814","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER012W"}


id: YER013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05025":null,"YER013W":null},"has_protein_features":false,"name":"PRP22","ortholog_annotations":[{"gene_uniquename":"YER013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05025","reference_uniquename":"PMID:29761456"}],"product":"DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase; associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes; required for proofreading the exon ligation reaction","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000815","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER013W"}


id: YER014C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BUD25","product":"Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern","secondary_identifier":"SGD:S000007590","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER014C-A"}


id: YER014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02876":null,"YER014W":null},"has_protein_features":false,"name":"HEM14","ortholog_annotations":[{"gene_uniquename":"YER014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02876","reference_uniquename":"PMID:29761456"}],"product":"Protoporphyrinogen oxidase; a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000816","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER014W"}


id: YER015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FAA2","product":"Medium chain fatty acyl-CoA synthetase; activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon","secondary_identifier":"SGD:S000000817","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER015W"}


id: YER016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02045":null,"YER016W":null},"has_protein_features":false,"name":"BIM1","ortholog_annotations":[{"gene_uniquename":"YER016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02045","reference_uniquename":"PMID:29761456"}],"product":"Microtubule plus end-tracking protein; forms a complex with Kar9p that makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally; homolog of human end binding protein 1 (EB1)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000818","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER016W"}


id: YER017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01179":null,"YER017C":null},"has_protein_features":false,"name":"AFG3","ortholog_annotations":[{"gene_uniquename":"YER017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01179","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging; expression of human homolog AFG3L2 can complement yeast yta12 afg3 double mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000819","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER017C"}


id: YER018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03683":null,"YER018C":null},"has_protein_features":false,"name":"SPC25","ortholog_annotations":[{"gene_uniquename":"YER018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03683","reference_uniquename":"PMID:29761456"}],"product":"Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000820","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER018C"}


id: YER019C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00064":null,"YER019C-A":null},"has_protein_features":false,"name":"SBH2","ortholog_annotations":[{"gene_uniquename":"YER019C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00064","reference_uniquename":"PMID:29761456"}],"product":"Ssh1p-Sss1p-Sbh2p complex component; involved in protein translocation into the endoplasmic reticulum; SBH2 has a paralog, SBH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002127","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER019C-A"}


id: YER019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01219":null,"YER019W":null},"has_protein_features":false,"name":"ISC1","ortholog_annotations":[{"gene_uniquename":"YER019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01219","reference_uniquename":"PMID:29761456"}],"product":"Inositol phosphosphingolipid phospholipase C; hydrolyzes complex sphingolipids to produce ceramide; regulates the spindle assembly checkpoint upstream of PP2A-Cdc55; activates genes required for non-fermentable carbon source metabolism during the diauxic shift; mediates Na+ and Li+ halotolerance; activated by phosphatidylserine, cardiolipin and phosphatidylglycerol; mitochondrial outer membrane protein; ortholog of mammalian neutral sphingomyelinase type 2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000821","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER019W"}


id: YER020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02444":null,"YER020W":null},"has_protein_features":false,"name":"GPA2","ortholog_annotations":[{"gene_uniquename":"YER020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02444","reference_uniquename":"PMID:29761456"}],"product":"Nucleotide binding alpha subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p, has signaling role in response to nutrients; required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000822","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER020W"}


id: YER021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04572":null,"YER021W":null},"has_protein_features":false,"name":"RPN3","ortholog_annotations":[{"gene_uniquename":"YER021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04572","reference_uniquename":"PMID:29761456"}],"product":"Essential non-ATPase regulatory subunit of the 26S proteasome lid; similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000823","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER021W"}


id: YER022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00904":null,"YER022W":null},"has_protein_features":false,"name":"SRB4","ortholog_annotations":[{"gene_uniquename":"YER022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00904","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for basal RNA polymerase II transcription; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000824","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER022W"}


id: YER023C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene PRO3; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028622","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER023C-A"}


id: YER023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00120":null,"YER023W":null},"has_protein_features":false,"name":"PRO3","ortholog_annotations":[{"gene_uniquename":"YER023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00120","reference_uniquename":"PMID:29761456"}],"product":"Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000825","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER023W"}


id: YER024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YAT2","product":"Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane","secondary_identifier":"SGD:S000000826","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER024W"}


id: YER025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00466":null,"YER025W":null},"has_protein_features":false,"name":"GCD11","ortholog_annotations":[{"gene_uniquename":"YER025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00466","reference_uniquename":"PMID:29761456"}],"product":"Gamma subunit of the translation initiation factor eIF2; involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; mutations in human ortholog cause X-linked intellectual disability (XLID) syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000827","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER025W"}


id: YER026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01233":null,"YER026C":null},"has_protein_features":false,"name":"CHO1","ortholog_annotations":[{"gene_uniquename":"YER026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01233","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylserine synthase; functions in phospholipid biosynthesis; transcriptionally repressed by myo-inositol and choline","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000828","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER026C"}


id: YER027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03802":null,"YER027C":null},"has_protein_features":false,"name":"GAL83","ortholog_annotations":[{"gene_uniquename":"YER027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03802","reference_uniquename":"PMID:29761456"}],"product":"One of three alternate beta-subunits of the Snf1 kinase complex; allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; necessary and sufficient for phosphorylation of the Mig2p transcription factor in response to alkaline stress; functionally redundant with SIP1 and SIP2 for the phosphorylation of Mig1p in response to glucose deprivation; contains a glycogen-binding domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000829","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER027C"}


id: YER028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03473":null,"SJAG_03911":null,"YER028C":null},"has_protein_features":false,"name":"MIG3","ortholog_annotations":[{"gene_uniquename":"YER028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03473","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03911","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000830","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER028C"}


id: YER029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02279":null,"YER029C":null},"has_protein_features":false,"name":"SMB1","ortholog_annotations":[{"gene_uniquename":"YER029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02279","reference_uniquename":"PMID:29761456"}],"product":"Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000831","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER029C"}


id: YER030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02035":null,"YER030W":null},"has_protein_features":false,"name":"CHZ1","ortholog_annotations":[{"gene_uniquename":"YER030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02035","reference_uniquename":"PMID:29761456"}],"product":"Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000832","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER030W"}


id: YER031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03915":null,"YER031C":null},"has_protein_features":false,"name":"YPT31","ortholog_annotations":[{"gene_uniquename":"YER031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03915","reference_uniquename":"PMID:29761456"}],"product":"Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication; localizes to the transitional and late Golgi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000833","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER031C"}


id: YER032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FIR1","product":"Protein involved in 3' mRNA processing; interacts with Ref2p; APCC(Cdh1) substrate; potential Cdc28p substrate","secondary_identifier":"SGD:S000000834","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER032W"}


id: YER033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ZRG8","product":"Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency","secondary_identifier":"SGD:S000000835","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER033C"}


id: YER034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000000836","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER034W"}


id: YER035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01746":null,"YER035W":null},"has_protein_features":false,"name":"EDC2","ortholog_annotations":[{"gene_uniquename":"YER035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01746","reference_uniquename":"PMID:29761456"}],"product":"RNA-binding protein that directly activates mRNA decapping; binds mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein increases in abundance and relocalizes to nucleolus and to nuclear foci upon DNA replication stress; EDC2 has a paralog, EDC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000837","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER035W"}


id: YER036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00599":null,"YER036C":null},"has_protein_features":false,"name":"ARB1","ortholog_annotations":[{"gene_uniquename":"YER036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00599","reference_uniquename":"PMID:29761456"}],"product":"ATPase of the ATP-binding cassette (ABC) family; involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; important for disaggregation of ordered and disordered aggregates; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p; human homolog ABCF2 can complement yeast ARB1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000838","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER036C"}


id: YER037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02593":null,"YER037W":null},"has_protein_features":false,"name":"PHM8","ortholog_annotations":[{"gene_uniquename":"YER037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02593","reference_uniquename":"PMID:29761456"}],"product":"Lysophosphatidic acid (LPA) phosphatase, nucleotidase; principle and physiological nucleotidase working on GMP, UMP and CMP; involved in LPA hydrolysis in response to phosphate starvation and ribose salvage pathway; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p; repressed by Gcn4p under normal conditions; PHM8 has a paralog, SDT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000839","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER037W"}


id: YER038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00213":null,"YER038C":null},"has_protein_features":false,"name":"KRE29","ortholog_annotations":[{"gene_uniquename":"YER038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00213","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000840","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER038C"}


id: YER038W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FMP49","product":"Mitochondrial protein of unknown function; almost completely overlaps ORF HVG1/YER039C","secondary_identifier":"SGD:S000028746","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER038W-A"}


id: YER039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00339":null,"YER039C":null},"has_protein_features":false,"name":"HVG1","ortholog_annotations":[{"gene_uniquename":"YER039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00339","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; HVG1 has a paralog, VRG4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000841","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER039C"}


id: YER039C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00339":null,"YER039C-A":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YER039C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00339","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; YER039C-A is not an essential gene","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000007226","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER039C-A"}


id: YER040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02730":null,"YER040W":null},"has_protein_features":false,"name":"GLN3","ortholog_annotations":[{"gene_uniquename":"YER040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02730","reference_uniquename":"PMID:26896847"}],"product":"Transcriptional activator in nitrogen catabolite repression system; localization and activity regulated by quality of nitrogen source and Ure2p; full-length protein forms prion-like aggregates when overproduced","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000000842","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER040W"}


id: YER041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YEN1","product":"Holliday junction resolvase; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1; similar to S. cerevisiae endonuclease Rth1p","secondary_identifier":"SGD:S000000843","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER041W"}


id: YER042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00419":null,"YER042W":null},"has_protein_features":false,"name":"MXR1","ortholog_annotations":[{"gene_uniquename":"YER042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00419","reference_uniquename":"PMID:29761456"}],"product":"Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; reduced activity of human homolog implicated in Alzheimer disease","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000844","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER042W"}


id: YER043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03556":null,"YER043C":null},"has_protein_features":false,"name":"SAH1","ortholog_annotations":[{"gene_uniquename":"YER043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03556","reference_uniquename":"PMID:29761456"}],"product":"S-adenosyl-L-homocysteine hydrolase; catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor; regulates cellular lipid homoeostasis by regulating phosphatidylcholine(PC)synthesis and triacylglycerol (TG) levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000845","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER043C"}


id: YER044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00453":null,"YER044C":null},"has_protein_features":false,"name":"ERG28","ortholog_annotations":[{"gene_uniquename":"YER044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00453","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum membrane protein; may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000846","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER044C"}


id: YER044C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02490":null,"YER044C-A":null},"has_protein_features":false,"name":"MEI4","ortholog_annotations":[{"gene_uniquename":"YER044C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02490","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein involved in forming DSBs; involved in double-strand break (DSBs) formation during meiotic recombination; required for chromosome synapsis and production of viable spores","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001954","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER044C-A"}


id: YER045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ACA1","product":"ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000847","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER045C"}


id: YER046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00974":null,"YER046W":null},"has_protein_features":false,"name":"SPO73","ortholog_annotations":[{"gene_uniquename":"YER046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00974","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein required for prospore membrane morphogenesis; required for the proper shape of the prospore membrane (PSM) and for spore wall formation; functions cooperatively with SPO71 in PSM elongation; physically interacts with Spo71p; genetically antagonistic to SPO1, similar to SPO71; localizes to the PSM; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; dysferlin domain-only protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000848","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER046W"}


id: YER046W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SAP1/YER047C","secondary_identifier":"SGD:S000028747","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER046W-A"}


id: YER047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01530":null,"SJAG_04566":null,"YER047C":null},"has_protein_features":false,"name":"SAP1","ortholog_annotations":[{"gene_uniquename":"YER047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01530","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04566","reference_uniquename":"PMID:29761456"}],"product":"Putative ATPase of the AAA family; interacts with the Sin1p transcriptional repressor in the two-hybrid system","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000849","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER047C"}


id: YER048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02034":null,"SJAG_02797":null,"YER048C":null},"has_protein_features":false,"name":"CAJ1","ortholog_annotations":[{"gene_uniquename":"YER048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02797","reference_uniquename":"PMID:29761456"}],"product":"Nuclear type II J heat shock protein of the E. coli dnaJ family; overexpression stabilizes amino acid permeases; contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly; localizes to the cytosol and plasma membrane, while a GFP fusion protein localizes to the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000850","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER048C"}


id: YER048W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00894":null,"YER048W-A":null},"has_protein_features":false,"name":"ISD11","ortholog_annotations":[{"gene_uniquename":"YER048W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00894","reference_uniquename":"PMID:29761456"}],"product":"Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis; exclusive to eukaryotes, implicated as eukaryotic supplement to the bacterium-derived Fe-S cluster (ISC) assembly apparatus; involved in regulation of iron metabolism; member of the LYR protein family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER048W-A"}


id: YER049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00642":null,"YER049W":null},"has_protein_features":false,"name":"TPA1","ortholog_annotations":[{"gene_uniquename":"YER049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00642","reference_uniquename":"PMID:29761456"}],"product":"Prolyl hydroxylase; catalyzes oxygen-dependent dihydroxylation of Rps23a/b, a 40S ribosomal decoding center subunit; influences translational termination and regulates translational accuracy; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; disputed role as a oxidative dealkylase repairing DNA methyl-base lesions; poly(rA)-binding protein affecting poly(A) tail length and mRNA stability; Fe(II)/2-oxoglutarate-dependent dioxygenase family member similar to human prolyl 4-hydroxylase OGFOD1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000851","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER049W"}


id: YER050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04281":null,"YER050C":null},"has_protein_features":false,"name":"RSM18","ortholog_annotations":[{"gene_uniquename":"YER050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04281","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S18 ribosomal protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000852","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER050C"}


id: YER051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03664":null,"YER051W":null},"has_protein_features":false,"name":"JHD1","ortholog_annotations":[{"gene_uniquename":"YER051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03664","reference_uniquename":"PMID:29761456"}],"product":"JmjC domain family histone demethylase specific for H3-K36; similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000853","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER051W"}


id: YER052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00881":null,"YER052C":null},"has_protein_features":false,"name":"HOM3","ortholog_annotations":[{"gene_uniquename":"YER052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00881","reference_uniquename":"PMID:29761456"}],"product":"Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000854","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER052C"}


id: YER053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00547":null,"YER053C":null},"has_protein_features":false,"name":"PIC2","ortholog_annotations":[{"gene_uniquename":"YER053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00547","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial copper and phosphate carrier; imports copper and inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000855","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER053C"}


id: YER053C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000007523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER053C-A"}


id: YER054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GIP2","product":"Putative regulatory subunit of protein phosphatase Glc7p; involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p; GIP2 has a paralog, PIG2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000856","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER054C"}


id: YER055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04747":null,"YER055C":null},"has_protein_features":false,"name":"HIS1","ortholog_annotations":[{"gene_uniquename":"YER055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04747","reference_uniquename":"PMID:29761456"}],"product":"ATP phosphoribosyltransferase; a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000857","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER055C"}


id: YER056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FCY2","product":"Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress","secondary_identifier":"SGD:S000000858","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER056C"}


id: YER056C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01853":null,"SJAG_05216":null,"YER056C-A":null},"has_protein_features":false,"name":"RPL34A","ortholog_annotations":[{"gene_uniquename":"YER056C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01853","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER056C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05216","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002135","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER056C-A"}


id: YER057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00107":null,"YER057C":null},"has_protein_features":false,"name":"HMF1","ortholog_annotations":[{"gene_uniquename":"YER057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00107","reference_uniquename":"PMID:29761456"}],"product":"Member of the p14.5 protein family; functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro; HMF1 has a paralog, MMF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000859","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER057C"}


id: YER058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00852":null,"YER058W":null},"has_protein_features":false,"name":"PET117","ortholog_annotations":[{"gene_uniquename":"YER058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00852","reference_uniquename":"PMID:29761456"}],"product":"Assembly factor that couples heme a synthesis to complex IV assembly; regulates the oligomerization state of the Cox15p heme a synthase, and couples this to the assembly of the cytochrome C oxidase complex (complex IV)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000860","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER058W"}


id: YER059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05978":null,"YER059W":null},"has_protein_features":false,"name":"PCL6","ortholog_annotations":[{"gene_uniquename":"YER059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05978","reference_uniquename":"PMID:29761456"}],"product":"Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding; PCL6 has a paralog, PCL7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000861","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER059W"}


id: YER060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FCY21","product":"Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function","secondary_identifier":"SGD:S000000862","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER060W"}


id: YER060W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FCY22","product":"Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function","secondary_identifier":"SGD:S000002958","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER060W-A"}


id: YER061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01946":null,"YER061C":null},"has_protein_features":false,"name":"CEM1","ortholog_annotations":[{"gene_uniquename":"YER061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01946","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial beta-keto-acyl synthase; possible role in fatty acid synthesis; required for mitochondrial respiration; human homolog OXSM can complement yeast cem1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000863","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER061C"}


id: YER062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GPP2","product":"DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis; also known as glycerol-1-phosphatase; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; GPP2 has a paralog, GPP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000864","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER062C"}


id: YER063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02534":null,"YER063W":null},"has_protein_features":false,"name":"THO1","ortholog_annotations":[{"gene_uniquename":"YER063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02534","reference_uniquename":"PMID:29761456"}],"product":"Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000865","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER063W"}


id: YER064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"VHR2","product":"Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000000866","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER064C"}


id: YER065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ICL1","product":"Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose","secondary_identifier":"SGD:S000000867","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER065C"}


id: YER066C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YER067W","secondary_identifier":"SGD:S000002959","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER066C-A"}


id: YER066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RRT13","product":"Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription","secondary_identifier":"SGD:S000000868","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER066W"}


