# genes

id: YKL110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01024":null,"YKL110C":null},"has_protein_features":false,"name":"KTI12","ortholog_annotations":[{"gene_uniquename":"YKL110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01024","reference_uniquename":"PMID:29761456"}],"product":"Protein that plays a role in modification of tRNA wobble nucleosides; protein plays role in tRNA wobble nucleoside modification with Elongator complex; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001593","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL110C"}


id: YKL111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1","secondary_identifier":"SGD:S000001594","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL111C"}


id: YKL112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ABF1","product":"DNA binding protein with possible chromatin-reorganizing activity; involved in transcriptional activation, gene silencing, and DNA replication and repair","secondary_identifier":"SGD:S000001595","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL112W"}


id: YKL113C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01648":null,"YKL113C":null},"has_protein_features":false,"name":"RAD27","ortholog_annotations":[{"gene_uniquename":"YKL113C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01648","reference_uniquename":"PMID:29761456"}],"product":"5' to 3' exonuclease, 5' flap endonuclease; required for Okazaki fragment processing and maturation, for long-patch base-excision repair and large loop repair (LLR), ribonucleotide excision repair; member of the S. pombe RAD2/FEN1 family; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001596","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL113C"}


id: YKL114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03665":null,"YKL114C":null},"has_protein_features":false,"name":"APN1","ortholog_annotations":[{"gene_uniquename":"YKL114C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03665","reference_uniquename":"PMID:29761456"}],"product":"Major apurinic/apyrimidinic endonuclease; 3'-repair diesterase; involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine; genetically interacts with NTG1 to maintain mitochondrial genome integrity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001597","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL114C"}


id: YKL115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRR1","secondary_identifier":"SGD:S000001598","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL115C"}


id: YKL116C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PRR1","product":"Serine/threonine protein kinase; inhibits pheromone induced signaling downstream of MAPK, possibly at the level of the Ste12p transcription factor","secondary_identifier":"SGD:S000001599","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL116C"}


id: YKL117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03784":null,"YKL117W":null},"has_protein_features":false,"name":"SBA1","ortholog_annotations":[{"gene_uniquename":"YKL117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03784","reference_uniquename":"PMID:29761456"}],"product":"Co-chaperone that binds and regulates Hsp90 family chaperones; plays a role in determining prion variants; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001600","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL117W"}


id: YKL118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPH2","secondary_identifier":"SGD:S000001601","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL118W"}


id: YKL119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06514":null,"YKL119C":null},"has_protein_features":false,"name":"VPH2","ortholog_annotations":[{"gene_uniquename":"YKL119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06514","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER); involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001602","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL119C"}


id: YKL120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00671":null,"YKL120W":null},"has_protein_features":false,"name":"OAC1","ortholog_annotations":[{"gene_uniquename":"YKL120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00671","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane transporter; transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001603","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL120W"}


id: YKL121W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01563":null,"SJAG_03432":null,"YKL121W":null},"has_protein_features":false,"name":"DGR2","ortholog_annotations":[{"gene_uniquename":"YKL121W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01563","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL121W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03432","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds; DGR2 has a paralog, YMR102C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001604","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL121W"}


id: YKL122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03411":null,"YKL122C":null},"has_protein_features":false,"name":"SRP21","ortholog_annotations":[{"gene_uniquename":"YKL122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03411","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the signal recognition particle (SRP); SRP functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001605","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL122C"}


id: YKL123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SSH4","secondary_identifier":"SGD:S000001606","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL123W"}


id: YKL124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01586":null,"YKL124W":null},"has_protein_features":false,"name":"SSH4","ortholog_annotations":[{"gene_uniquename":"YKL124W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01586","reference_uniquename":"PMID:29761456"}],"product":"Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001607","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL124W"}


id: YKL125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01744":null,"YKL125W":null},"has_protein_features":false,"name":"RRN3","ortholog_annotations":[{"gene_uniquename":"YKL125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01744","reference_uniquename":"PMID:29761456"}],"product":"Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL125W"}


id: YKL126W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04206":null,"YKL126W":null},"has_protein_features":false,"name":"YPK1","ortholog_annotations":[{"gene_uniquename":"YKL126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04206","reference_uniquename":"PMID:29761456"}],"product":"S/T protein kinase; required for PM lipid and protein homeostasis; involved in sphingolipid-mediated and cell integrity signaling pathways and endocytosis; phosphorylates and downregulates Fpk1p; phosphorylates and inactivates Orm1p/2p when sphingolipid synthesis is compromised; role in TORC1/2-dependent Rps6a/b phosphorylation; phosphorylated and activated by TORC2 and by Pkh1/2p in the presence of phytosphingosine; human homolog SGK1 complements the null and inviability of a ypk1 ypk2 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL126W"}


id: YKL127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01209":null,"YKL127W":null},"has_protein_features":false,"name":"PGM1","ortholog_annotations":[{"gene_uniquename":"YKL127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01209","reference_uniquename":"PMID:29761456"}],"product":"Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; PGM1 has a paralog, PGM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001610","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL127W"}


id: YKL128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02984":null,"SJAG_03714":null,"YKL128C":null},"has_protein_features":false,"name":"PMU1","ortholog_annotations":[{"gene_uniquename":"YKL128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02984","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03714","reference_uniquename":"PMID:29761456"}],"product":"Putative phosphomutase; contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001611","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL128C"}


id: YKL129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04001":null,"YKL129C":null},"has_protein_features":false,"name":"MYO3","ortholog_annotations":[{"gene_uniquename":"YKL129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04001","reference_uniquename":"PMID:29761456"}],"product":"One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO3 has a paralog, MYO5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001612","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL129C"}


id: YKL130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SHE2","product":"RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; binds to ER-derived membranes and targets mRNAs to cortical ER","secondary_identifier":"SGD:S000001613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL130C"}


id: YKL131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001614","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL131W"}


id: YKL132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00529":null,"YKL132C":null},"has_protein_features":false,"name":"RMA1","ortholog_annotations":[{"gene_uniquename":"YKL132C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00529","reference_uniquename":"PMID:29761456"}],"product":"Putative dihydrofolate synthetase; similar to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; RMA1 has a paralog, FOL3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001615","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL132C"}


id: YKL133C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00354":null,"YKL133C":null},"has_protein_features":false,"name":"RCI50","ortholog_annotations":[{"gene_uniquename":"YKL133C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00354","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein of unknown function; not required for growth of cells lacking the mitochondrial genome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; YKL133C has a paralog, MGR3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001616","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL133C"}


id: YKL134C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01004":null,"YKL134C":null},"has_protein_features":false,"name":"OCT1","ortholog_annotations":[{"gene_uniquename":"YKL134C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01004","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial intermediate peptidase; cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001617","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL134C"}


id: YKL135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02453":null,"SJAG_04565":null,"YKL135C":null},"has_protein_features":false,"name":"APL2","ortholog_annotations":[{"gene_uniquename":"YKL135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02453","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YKL135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04565","reference_uniquename":"PMID:29761456"}],"product":"Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001618","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL135C"}


id: YKL136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C","secondary_identifier":"SGD:S000001619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL136W"}


id: YKL137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01140":null,"SJAG_05398":null,"YKL137W":null},"has_protein_features":false,"name":"CMC1","ortholog_annotations":[{"gene_uniquename":"YKL137W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01140","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL137W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05398","reference_uniquename":"PMID:29761456"}],"product":"Copper-binding protein of the mitochondrial intermembrane space; evolutionarily conserved; may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001620","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL137W"}


id: YKL138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04216":null,"YKL138C":null},"has_protein_features":false,"name":"MRPL31","ortholog_annotations":[{"gene_uniquename":"YKL138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04216","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001621","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL138C"}


id: YKL138C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02731":null,"YKL138C-A":null},"has_protein_features":false,"name":"HSK3","ortholog_annotations":[{"gene_uniquename":"YKL138C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02731","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL138C-A"}


id: YKL139W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03967":null,"YKL139W":null},"has_protein_features":false,"name":"CTK1","ortholog_annotations":[{"gene_uniquename":"YKL139W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03967","reference_uniquename":"PMID:29761456"}],"product":"Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; required for H3K36 trimethylation but not dimethylation by Set2p; suggested stimulatory role in 80S formation during translation initiation; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001622","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL139W"}


id: YKL140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00158":null,"SJAG_02068":null,"SJAG_04790":null,"YKL140W":null},"has_protein_features":false,"name":"TGL1","ortholog_annotations":[{"gene_uniquename":"YKL140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00158","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02068","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04790","reference_uniquename":"PMID:29761456"}],"product":"Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001623","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL140W"}


id: YKL141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03920":null,"YKL141W":null},"has_protein_features":false,"name":"SDH3","ortholog_annotations":[{"gene_uniquename":"YKL141W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03920","reference_uniquename":"PMID:29761456"}],"product":"Subunit of succinate dehydrogenase and of TIM22 translocase; functions as cytochrome b subunit of succinate dehydrogenase, which couples oxidation of succinate to transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex; SDH3 has a paralog, SHH3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001624","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL141W"}


id: YKL142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03489":null,"YKL142W":null},"has_protein_features":false,"name":"MRP8","ortholog_annotations":[{"gene_uniquename":"YKL142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03489","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001625","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL142W"}


id: YKL143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01338":null,"YKL143W":null},"has_protein_features":false,"name":"LTV1","ortholog_annotations":[{"gene_uniquename":"YKL143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01338","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the EGO/GSE complex; the vacuolar/endosomal membrane associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from the endosome to the plasma membrane; required for ribosomal small subunit export from nucleus; required for growth at low temperature","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL143W"}


id: YKL144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02600":null,"YKL144C":null},"has_protein_features":false,"name":"RPC25","ortholog_annotations":[{"gene_uniquename":"YKL144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02600","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase III subunit C25; required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL144C"}


id: YKL145W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01489":null,"YKL145W":null},"has_protein_features":false,"name":"RPT1","ortholog_annotations":[{"gene_uniquename":"YKL145W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01489","reference_uniquename":"PMID:29761456"}],"product":"ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL145W"}


id: YKL145W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified essential gene RPT1; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028841","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL145W-A"}


id: YKL146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03400":null,"YKL146W":null},"has_protein_features":false,"name":"AVT3","ortholog_annotations":[{"gene_uniquename":"YKL146W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03400","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL146W"}


id: YKL147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3","secondary_identifier":"SGD:S000001630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL147C"}


id: YKL148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01671":null,"YKL148C":null},"has_protein_features":false,"name":"SDH1","ortholog_annotations":[{"gene_uniquename":"YKL148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01671","reference_uniquename":"PMID:29761456"}],"product":"Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits; mutations in human ortholog SDHA are associated with Leigh syndrome and predisposition to several cancers","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL148C"}


id: YKL149C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01433":null,"YKL149C":null},"has_protein_features":false,"name":"DBR1","ortholog_annotations":[{"gene_uniquename":"YKL149C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01433","reference_uniquename":"PMID:29761456"}],"product":"RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies; human homolog DBR1 can complement yeast dbr1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL149C"}


id: YKL150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MCR1","product":"Mitochondrial NADH-cytochrome b5 reductase; involved in ergosterol biosynthesis","secondary_identifier":"SGD:S000001633","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL150W"}


id: YKL151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03669":null,"YKL151C":null},"has_protein_features":false,"name":"NNR2","ortholog_annotations":[{"gene_uniquename":"YKL151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03669","reference_uniquename":"PMID:29761456"}],"product":"Widely-conserved NADHX dehydratase; converts (S)-NADHX to NADH in ATP-dependent manner; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; downstream intergenic region drives antisense expression and mediates coordinated regulation of YKL151C and GPM1 phosphoglycerate mutase; protein abundance increases in response to DNA replication stress; homolog of Carkd in mammals and C-terminus of YjeF in E.coli","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001634","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL151C"}


id: YKL152C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02009":null,"YKL152C":null},"has_protein_features":false,"name":"GPM1","ortholog_annotations":[{"gene_uniquename":"YKL152C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02009","reference_uniquename":"PMID:29761456"}],"product":"Tetrameric phosphoglycerate mutase; mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001635","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL152C"}


id: YKL153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant","secondary_identifier":"SGD:S000001636","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL153W"}


id: YKL154W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00360":null,"YKL154W":null},"has_protein_features":false,"name":"SRP102","ortholog_annotations":[{"gene_uniquename":"YKL154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00360","reference_uniquename":"PMID:29761456"}],"product":"Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001637","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL154W"}


id: YKL155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03322":null,"YKL155C":null},"has_protein_features":false,"name":"RSM22","ortholog_annotations":[{"gene_uniquename":"YKL155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03322","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent RNA methyltransferase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL155C"}


id: YKL156C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene RPS27A; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028668","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL156C-A"}


id: YKL156W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02340":null,"YKL156W":null},"has_protein_features":false,"name":"RPS27A","ortholog_annotations":[{"gene_uniquename":"YKL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02340","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001639","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL156W"}


id: YKL157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00181":null,"YKL157W":null},"has_protein_features":false,"name":"APE2","ortholog_annotations":[{"gene_uniquename":"YKL157W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00181","reference_uniquename":"PMID:29761456"}],"product":"Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001640","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL157W"}


id: YKL158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YKL158W was originally annotated as an independent ORF, but was later demonstrated to be an exon of an adjacent ORF, YKL157W","secondary_identifier":"SGD:S000028807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL158W"}


id: YKL159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04871":null,"YKL159C":null},"has_protein_features":false,"name":"RCN1","ortholog_annotations":[{"gene_uniquename":"YKL159C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04871","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL159C"}


id: YKL160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04353":null,"YKL160W":null},"has_protein_features":false,"name":"ELF1","ortholog_annotations":[{"gene_uniquename":"YKL160W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04353","reference_uniquename":"PMID:29761456"}],"product":"Transcription elongation factor with a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL160W"}


id: YKL161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"KDX1","product":"Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL161C"}


id: YKL162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion","secondary_identifier":"SGD:S000001645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL162C"}


id: YKL162C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL162C-A"}


id: YKL163W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PIR3","product":"O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; coding sequence contains length polymorphisms in different strains; PIR3 has a paralog, HSP150, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL163W"}


id: YKL164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PIR1","product":"O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL164C"}


id: YKL165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04165":null,"YKL165C":null},"has_protein_features":false,"name":"MCD4","ortholog_annotations":[{"gene_uniquename":"YKL165C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04165","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in GPI anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes; GPI stands for glycosylphosphatidylinositol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001648","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL165C"}


id: YKL165C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007617","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL165C-A"}


id: YKL166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04312":null,"YKL166C":null},"has_protein_features":false,"name":"TPK3","ortholog_annotations":[{"gene_uniquename":"YKL166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04312","reference_uniquename":"PMID:29761456"}],"product":"cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001649","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL166C"}


id: YKL167C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05270":null,"YKL167C":null},"has_protein_features":false,"name":"MRP49","ortholog_annotations":[{"gene_uniquename":"YKL167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05270","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001650","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL167C"}


id: YKL168C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"KKQ8","product":"Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL168C"}


id: YKL169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38","secondary_identifier":"SGD:S000001652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL169C"}


id: YKL170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00315":null,"YKL170W":null},"has_protein_features":false,"name":"MRPL38","ortholog_annotations":[{"gene_uniquename":"YKL170W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00315","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001653","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL170W"}


id: YKL171W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04655":null,"YKL171W":null},"has_protein_features":false,"name":"NNK1","ortholog_annotations":[{"gene_uniquename":"YKL171W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04655","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001654","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL171W"}


id: YKL172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03413":null,"YKL172W":null},"has_protein_features":false,"name":"EBP2","ortholog_annotations":[{"gene_uniquename":"YKL172W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03413","reference_uniquename":"PMID:29761456"}],"product":"Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL172W"}


id: YKL173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00414":null,"YKL173W":null},"has_protein_features":false,"name":"SNU114","ortholog_annotations":[{"gene_uniquename":"YKL173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00414","reference_uniquename":"PMID:29761456"}],"product":"GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL173W"}


id: YKL174C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00015":null,"SJAG_00019":null,"SJAG_01096":null,"SJAG_02062":null,"SJAG_02113":null,"SJAG_02133":null,"SJAG_02144":null,"SJAG_02941":null,"SJAG_04135":null,"SJAG_04673":null,"SJAG_06598":null,"YKL174C":null},"has_protein_features":false,"name":"TPO5","ortholog_annotations":[{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00015","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00019","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01096","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02062","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02113","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02133","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02144","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02941","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04135","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04673","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06598","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL174C"}


id: YKL175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01990":null,"YKL175W":null},"has_protein_features":false,"name":"ZRT3","ortholog_annotations":[{"gene_uniquename":"YKL175W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01990","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane zinc transporter; transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL175W"}


id: YKL176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04910":null,"YKL176C":null},"has_protein_features":false,"name":"LST4","ortholog_annotations":[{"gene_uniquename":"YKL176C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04910","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino acid stimulation; required for activation of TORC1 in response to amino acid stimulation; recruited to the vacuolar membrane during amino acid starvation and released from the membrane by TORC1; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL176C"}


id: YKL177W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3","secondary_identifier":"SGD:S000001660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL177W"}


id: YKL178C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01345":null,"YKL178C":null},"has_protein_features":false,"name":"STE3","ortholog_annotations":[{"gene_uniquename":"YKL178C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01345","reference_uniquename":"PMID:29761456"}],"product":"Receptor for a factor pheromone; couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL178C"}


id: YKL179C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02316":null,"YKL179C":null},"has_protein_features":false,"name":"COY1","ortholog_annotations":[{"gene_uniquename":"YKL179C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02316","reference_uniquename":"PMID:29761456"}],"product":"Golgi membrane protein with similarity to mammalian CASP; packaged into COPII vesicles for trafficking between ER and Golgi; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL179C"}


id: YKL180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00940":null,"SJAG_01721":null,"YKL180W":null},"has_protein_features":false,"name":"RPL17A","ortholog_annotations":[{"gene_uniquename":"YKL180W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00940","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL180W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01721","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L17A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001663","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL180W"}


id: YKL181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04970":null,"YKL181W":null},"has_protein_features":false,"name":"PRS1","ortholog_annotations":[{"gene_uniquename":"YKL181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04970","reference_uniquename":"PMID:29761456"}],"product":"5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; plays a key role in cell wall integrity (CWI) pathway; one of five related enzymes, which are active as heteromultimeric complexes; missense mutations in human homolog PRPS1 are associated with neuropathic Arts syndrome and Charcot-Marie Tooth (CMTX5) disease","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001664","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL181W"}


id: YKL182W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04107":null,"YKL182W":null},"has_protein_features":false,"name":"FAS1","ortholog_annotations":[{"gene_uniquename":"YKL182W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04107","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001665","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL182W"}


id: YKL183C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028558","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL183C-A"}


id: YKL183W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03279":null,"YKL183W":null},"has_protein_features":false,"name":"LOT5","ortholog_annotations":[{"gene_uniquename":"YKL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03279","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001666","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL183W"}


id: YKL184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00043":null,"YKL184W":null},"has_protein_features":false,"name":"SPE1","ortholog_annotations":[{"gene_uniquename":"YKL184W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00043","reference_uniquename":"PMID:29761456"}],"product":"Ornithine decarboxylase; catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001667","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL184W"}


id: YKL185W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ASH1","product":"Component of the Rpd3L histone deacetylase complex; zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate","secondary_identifier":"SGD:S000001668","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL185W"}


id: YKL186C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04721":null,"YKL186C":null},"has_protein_features":false,"name":"MTR2","ortholog_annotations":[{"gene_uniquename":"YKL186C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04721","reference_uniquename":"PMID:29761456"}],"product":"mRNA transport regulator; essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL186C"}


id: YKL187C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FAT3","product":"Protein required for fatty acid uptake; protein abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; FAT3 has a paralog, YLR413W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001670","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL187C"}


id: YKL188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PXA2","product":"Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant","secondary_identifier":"SGD:S000001671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL188C"}


id: YKL189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00333":null,"YKL189W":null},"has_protein_features":false,"name":"HYM1","ortholog_annotations":[{"gene_uniquename":"YKL189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00333","reference_uniquename":"PMID:29761456"}],"product":"Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis; interacts with Sog2p; allosterically activates Kic1p; localizes to sites of polarized growth during budding and during the mating response","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL189W"}


id: YKL190W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03793":null,"YKL190W":null},"has_protein_features":false,"name":"CNB1","ortholog_annotations":[{"gene_uniquename":"YKL190W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03793","reference_uniquename":"PMID:29761456"}],"product":"Calcineurin B; regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (stress-response transcription factor); other calcineurin subunit encoded by CNA1 and/or CMP1; regulates function of Aly1p alpha-arrestin; myristoylation by Nmt1p reduces calcineurin activity in response to submaximal Ca signals, is needed to prevent constitutive phosphatase activity; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL190W"}


id: YKL191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04085":null,"YKL191W":null},"has_protein_features":false,"name":"DPH2","ortholog_annotations":[{"gene_uniquename":"YKL191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04085","reference_uniquename":"PMID:29761456"}],"product":"Protein required for synthesis of diphthamide; required along with Dph1p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); forms a complex with Dph1p that catalyzes the first step of diphthamide biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001674","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL191W"}


id: YKL192C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01238":null,"YKL192C":null},"has_protein_features":false,"name":"ACP1","ortholog_annotations":[{"gene_uniquename":"YKL192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01238","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial matrix acyl carrier protein; involved in biosynthesis of octanoate, which is a precursor to lipoic acid; coordinates mitochondrial fatty acid and iron sulfur cluster metabolism; activated by phosphopantetheinylation catalyzed by Ppt2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001675","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL192C"}


id: YKL193C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04968":null,"YKL193C":null},"has_protein_features":false,"name":"SDS22","ortholog_annotations":[{"gene_uniquename":"YKL193C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04968","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL193C"}


id: YKL194C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03585":null,"YKL194C":null},"has_protein_features":false,"name":"MST1","ortholog_annotations":[{"gene_uniquename":"YKL194C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03585","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(UAG)Q2 in vitro; lacks a typical editing domain, but has pre-transfer editing activity stimulated by the unusual tRNA-Thr","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL194C"}


id: YKL195W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00196":null,"YKL195W":null},"has_protein_features":false,"name":"MIA40","ortholog_annotations":[{"gene_uniquename":"YKL195W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00196","reference_uniquename":"PMID:29761456"}],"product":"Import and assembly protein in mitochondrial intermembrane space; component of MIA pathway which mediates import and oxidative folding of substrates including small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p via a chaperone-like activity; forms a dimer that binds iron-sulfur cluster in vitro","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL195W"}


id: YKL196C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00899":null,"YKL196C":null},"has_protein_features":false,"name":"YKT6","ortholog_annotations":[{"gene_uniquename":"YKL196C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00899","reference_uniquename":"PMID:29761456"}],"product":"Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus; human homolog YKT6 can complement yeast ykt6 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001679","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL196C"}


id: YKL197C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02619":null,"YKL197C":null},"has_protein_features":false,"name":"PEX1","ortholog_annotations":[{"gene_uniquename":"YKL197C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02619","reference_uniquename":"PMID:29761456"}],"product":"AAA-peroxin; heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis; mutations in human PEX1 can lead to severe peroxisomal disorders and early death","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001680","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL197C"}


id: YKL198C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04469":null,"YKL198C":null},"has_protein_features":false,"name":"PTK1","ortholog_annotations":[{"gene_uniquename":"YKL198C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04469","reference_uniquename":"PMID:29761456"}],"product":"Putative serine/threonine protein kinase; regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein; PTK1 has a paralog, PTK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001681","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL198C"}


id: YKL199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YKL199C was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YKL198C","secondary_identifier":"SGD:S000001682","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL199C"}


id: YKL200C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YKL200C was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YKL201C","secondary_identifier":"SGD:S000001683","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL200C"}


id: YKL201C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MNN4","product":"Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; may also function as a mannosylphosphate transferase; expression increases in late-logarithmic and stationary growth phases; coding sequence contains length polymorphisms in different strains; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL201C"}


id: YKL202W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001685","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL202W"}


id: YKL203C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02723":null,"SJAG_03067":null,"YKL203C":null},"has_protein_features":false,"name":"TOR2","ortholog_annotations":[{"gene_uniquename":"YKL203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02723","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03067","reference_uniquename":"PMID:29761456"}],"product":"PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001686","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL203C"}


id: YKL204W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04291":null,"YKL204W":null},"has_protein_features":false,"name":"EAP1","ortholog_annotations":[{"gene_uniquename":"YKL204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04291","reference_uniquename":"PMID:29761456"}],"product":"eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001687","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL204W"}


id: YKL205W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02661":null,"YKL205W":null},"has_protein_features":false,"name":"LOS1","ortholog_annotations":[{"gene_uniquename":"YKL205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02661","reference_uniquename":"PMID:29761456"}],"product":"Nuclear pore protein; involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm; deletion mutation extends replicative lifespan, as does exclusion of Los1p from the nucleus in response to caloric restriction","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001688","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL205W"}


id: YKL206C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ADD66","product":"Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly","secondary_identifier":"SGD:S000001689","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL206C"}


id: YKL207W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01127":null,"YKL207W":null},"has_protein_features":false,"name":"EMC3","ortholog_annotations":[{"gene_uniquename":"YKL207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01127","reference_uniquename":"PMID:29761456"}],"product":"Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001690","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL207W"}


id: YKL208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CBT1","product":"Protein involved in 5' RNA end processing; substrates include mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p","secondary_identifier":"SGD:S000001691","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL208W"}


id: YKL209C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02602":null,"SJAG_03363":null,"YKL209C":null},"has_protein_features":false,"name":"STE6","ortholog_annotations":[{"gene_uniquename":"YKL209C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02602","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL209C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03363","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane ATP-binding cassette (ABC) transporter; required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells; human homolog ABCB1 mediates multidrug resistance in many chemotherapy-resistant tumors by effluxing toxic compounds from the cell","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001692","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL209C"}


id: YKL210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00853":null,"YKL210W":null},"has_protein_features":false,"name":"UBA1","ortholog_annotations":[{"gene_uniquename":"YKL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00853","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001693","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL210W"}


id: YKL211C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01455":null,"YKL211C":null},"has_protein_features":false,"name":"TRP3","ortholog_annotations":[{"gene_uniquename":"YKL211C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01455","reference_uniquename":"PMID:29761456"}],"product":"Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001694","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL211C"}


id: YKL212W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00880":null,"SJAG_02706":null,"YKL212W":null},"has_protein_features":false,"name":"SAC1","ortholog_annotations":[{"gene_uniquename":"YKL212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00880","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02706","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol phosphate phosphatase; role in early and medial Golgi PtdIns4P hydrolysis; regulated by Vps74p interaction; ER localized transmembrane protein which cycles through the Golgi; role in protein trafficking, processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis by modulating PtdIns(4)P metabolism; PtdIns4P PPase activity is crucial for autophagosome-vacuole fusion during autophagy; human homolog SACM1L complements autophagy defects of the null","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001695","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL212W"}


id: YKL213C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00312":null,"YKL213C":null},"has_protein_features":false,"name":"DOA1","ortholog_annotations":[{"gene_uniquename":"YKL213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00312","reference_uniquename":"PMID:29761456"}],"product":"WD-repeat protein involved in ubiquitin-mediated protein degradation; Ub-binding protein with a role in Ub homeostasis; substrate-recruiting adaptor for Cdc48p in mitochondria-associated degradation; inhibits degradation of Ufd2p-dependent substrates; facilitates proteolysis of Cse4p, a centromeric H3-like protein; required for ribophagy; promotes NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001696","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL213C"}


id: YKL214C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YRA2","product":"Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus","secondary_identifier":"SGD:S000001697","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL214C"}


id: YKL215C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01995":null,"YKL215C":null},"has_protein_features":false,"name":"OXP1","ortholog_annotations":[{"gene_uniquename":"YKL215C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01995","reference_uniquename":"PMID:29761456"}],"product":"5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001698","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL215C"}


id: YKL216W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00197":null,"YKL216W":null},"has_protein_features":false,"name":"URA1","ortholog_annotations":[{"gene_uniquename":"YKL216W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00197","reference_uniquename":"PMID:29761456"}],"product":"Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001699","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL216W"}


id: YKL217W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"JEN1","product":"Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose","secondary_identifier":"SGD:S000001700","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL217W"}


id: YKL218C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SRY1","product":"3-hydroxyaspartate dehydratase; deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity","secondary_identifier":"SGD:S000001701","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL218C"}


id: YKL219W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COS9","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000001702","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL219W"}


id: YKL220C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04743":null,"YKL220C":null},"has_protein_features":false,"name":"FRE2","ortholog_annotations":[{"gene_uniquename":"YKL220C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001703","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL220C"}


id: YKL221W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MCH2","product":"Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport","secondary_identifier":"SGD:S000001704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL221W"}


id: YKL222C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine","secondary_identifier":"SGD:S000001705","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL222C"}


id: YKL223W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001706","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL223W"}


id: YKL224C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU16","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole","secondary_identifier":"SGD:S000001707","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL224C"}


id: YKL225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001708","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL225W"}


id: YKR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02384":null,"YKR001C":null},"has_protein_features":false,"name":"VPS1","ortholog_annotations":[{"gene_uniquename":"YKR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02384","reference_uniquename":"PMID:29761456"}],"product":"Dynamin-like GTPase required for vacuolar sorting; promotes fission of retrograde transport carriers from endosome; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001709","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR001C"}


id: YKR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02720":null,"YKR002W":null},"has_protein_features":false,"name":"PAP1","ortholog_annotations":[{"gene_uniquename":"YKR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02720","reference_uniquename":"PMID:29761456"}],"product":"Poly(A) polymerase; one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001710","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR002W"}


id: YKR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01590":null,"SJAG_02323":null,"SJAG_02375":null,"SJAG_03718":null,"YKR003W":null},"has_protein_features":false,"name":"OSH6","ortholog_annotations":[{"gene_uniquename":"YKR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01590","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02323","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02375","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03718","reference_uniquename":"PMID:29761456"}],"product":"Oxysterol-binding  phosphatidylserine transferase; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion; OSH6 has a paralog, OSH7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001711","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR003W"}


id: YKR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ECM9","product":"Non-essential protein of unknown function","secondary_identifier":"SGD:S000001712","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR004C"}


id: YKR004C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discreet protein; YKR004C-A was originally annotated as an independent ORF, but was later demonstrated to be an exon of an adjacent ORF, YKR004C","secondary_identifier":"SGD:S000028559","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR004C-A"}


id: YKR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001713","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR005C"}


id: YKR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MRPL13","product":"Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation","secondary_identifier":"SGD:S000001714","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR006C"}


id: YKR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03928":null,"YKR007W":null},"has_protein_features":false,"name":"MEH1","ortholog_annotations":[{"gene_uniquename":"YKR007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03928","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the EGO/GSE complex; the vacuolar/endosomal membrane associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from the endosome to the plasma membrane; loss results in a defect in vacuolar acidification","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001715","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR007W"}


id: YKR008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00440":null,"YKR008W":null},"has_protein_features":false,"name":"RSC4","ortholog_annotations":[{"gene_uniquename":"YKR008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00440","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001716","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR008W"}


id: YKR009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FOX2","product":"3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase; multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; mutation is functionally complemented by human HSD17B4","secondary_identifier":"SGD:S000001717","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR009C"}


id: YKR010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00883":null,"YKR010C":null},"has_protein_features":false,"name":"TOF2","ortholog_annotations":[{"gene_uniquename":"YKR010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00883","reference_uniquename":"PMID:29761456"}],"product":"Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001718","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR010C"}


id: YKR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000001719","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR011C"}


id: YKR012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2","secondary_identifier":"SGD:S000001720","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR012C"}


id: YKR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PRY2","product":"Sterol binding protein involved in the export of acetylated sterols; role in sterol export is redundant with that of PRY1; redundant role with PRY1 and PRY3 in the export of free fatty acids; may be involved in detoxification of hydrophobic compounds; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins)","secondary_identifier":"SGD:S000001721","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR013W"}


id: YKR014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01379":null,"YKR014C":null},"has_protein_features":false,"name":"YPT52","ortholog_annotations":[{"gene_uniquename":"YKR014C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01379","reference_uniquename":"PMID:29761456"}],"product":"Endosomal Rab family GTPase; required for vacuolar protein sorting, endocytosis and multivesicular body (MVB) biogenesis and sorting; required for localization of the CORVET complex to endosomes; involved in autophagy and ionic stress tolerance; similar to Vps21p and Ypt53p; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001722","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR014C"}


id: YKR015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001723","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR015C"}


id: YKR016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02028":null,"YKR016W":null},"has_protein_features":false,"name":"MIC60","ortholog_annotations":[{"gene_uniquename":"YKR016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02028","reference_uniquename":"PMID:29761456"}],"product":"Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic60p is also involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; ortholog of mammalian mitofilin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR016W"}


id: YKR017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01533":null,"YKR017C":null},"has_protein_features":false,"name":"HEL1","ortholog_annotations":[{"gene_uniquename":"YKR017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01533","reference_uniquename":"PMID:29761456"}],"product":"RING finger ubiquitin ligase (E3); involved in ubiquitination and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001725","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR017C"}


id: YKR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00219":null,"SJAG_00270":null,"YKR018C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YKR018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00219","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00270","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001726","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR018C"}


id: YKR019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00724":null,"YKR019C":null},"has_protein_features":false,"name":"IRS4","ortholog_annotations":[{"gene_uniquename":"YKR019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00724","reference_uniquename":"PMID:29761456"}],"product":"EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001727","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR019C"}


id: YKR020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01645":null,"YKR020W":null},"has_protein_features":false,"name":"VPS51","ortholog_annotations":[{"gene_uniquename":"YKR020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01645","reference_uniquename":"PMID:29761456"}],"product":"Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; links the (VFT/GARP) complex to the SNARE Tlg1p; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001728","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR020W"}


id: YKR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00032":null,"SJAG_03643":null,"YKR021W":null},"has_protein_features":false,"name":"ALY1","ortholog_annotations":[{"gene_uniquename":"YKR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00032","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03643","reference_uniquename":"PMID:29761456"}],"product":"Alpha arrestin, substrate of calcineurin; controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; dephosphorylation of Aly1p required for the endocytosis of Dip5p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; ALY1 has a paralog, ALY2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001729","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR021W"}


id: YKR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00206":null,"YKR022C":null},"has_protein_features":false,"name":"NTR2","ortholog_annotations":[{"gene_uniquename":"YKR022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00206","reference_uniquename":"PMID:29761456"}],"product":"Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001730","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR022C"}


id: YKR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02096":null,"YKR023W":null},"has_protein_features":false,"name":"RQT4","ortholog_annotations":[{"gene_uniquename":"YKR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02096","reference_uniquename":"PMID:29761456"}],"product":"Subunit of ribosome-associated quality control trigger complex (RQT); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001731","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR023W"}


id: YKR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00583":null,"YKR024C":null},"has_protein_features":false,"name":"DBP7","ortholog_annotations":[{"gene_uniquename":"YKR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00583","reference_uniquename":"PMID:29761456"}],"product":"Putative ATP-dependent RNA helicase of the DEAD-box family; involved in ribosomal biogenesis; required at post-transcriptional step for efficient retrotransposition; essential for growth under anaerobic conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001732","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR024C"}


id: YKR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03921":null,"YKR025W":null},"has_protein_features":false,"name":"RPC37","ortholog_annotations":[{"gene_uniquename":"YKR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03921","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase III subunit C37","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001733","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR025W"}


id: YKR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03678":null,"YKR026C":null},"has_protein_features":false,"name":"GCN3","ortholog_annotations":[{"gene_uniquename":"YKR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03678","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of translation initiation factor eIF2B; guanine-nucleotide exchange factor for eIF2; activity regulated by phosphorylated eIF2; positive regulator of GCN4 expression; mutations in human ortholog EIF2B2 cause fatal brain disease childhood ataxia with central nervous system hypomyelination (CACH); human ortholog EIF2B1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001734","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR026C"}


id: YKR027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00916":null,"YKR027W":null},"has_protein_features":false,"name":"BCH2","ortholog_annotations":[{"gene_uniquename":"YKR027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00916","reference_uniquename":"PMID:29761456"}],"product":"Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001735","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR027W"}


id: YKR028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04638":null,"YKR028W":null},"has_protein_features":false,"name":"SAP190","ortholog_annotations":[{"gene_uniquename":"YKR028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04638","reference_uniquename":"PMID:29761456"}],"product":"Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001736","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR028W"}


id: YKR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04396":null,"YKR029C":null},"has_protein_features":false,"name":"SET3","ortholog_annotations":[{"gene_uniquename":"YKR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04396","reference_uniquename":"PMID:29761456"}],"product":"Defining member of the SET3 histone deacetylase complex; which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001737","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR029C"}


id: YKR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02910":null,"YKR030W":null},"has_protein_features":false,"name":"GMH1","ortholog_annotations":[{"gene_uniquename":"YKR030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02910","reference_uniquename":"PMID:29761456"}],"product":"Golgi membrane protein of unknown function; interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting; conserved from yeast to human","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001738","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR030W"}


id: YKR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01519":null,"YKR031C":null},"has_protein_features":false,"name":"SPO14","ortholog_annotations":[{"gene_uniquename":"YKR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01519","reference_uniquename":"PMID:29761456"}],"product":"Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with 'foot domain' of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001739","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR031C"}


id: YKR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000001740","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR032W"}


id: YKR033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80","secondary_identifier":"SGD:S000001741","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR033C"}


id: YKR034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00792":null,"YKR034W":null},"has_protein_features":false,"name":"DAL80","ortholog_annotations":[{"gene_uniquename":"YKR034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00792","reference_uniquename":"PMID:29761456"}],"product":"Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001742","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR034W"}


id: YKR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OPI8","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A","secondary_identifier":"SGD:S000001743","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR035C"}


id: YKR035W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00900":null,"YKR035W-A":null},"has_protein_features":false,"name":"DID2","ortholog_annotations":[{"gene_uniquename":"YKR035W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00900","reference_uniquename":"PMID:29761456"}],"product":"Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR035W-A"}


id: YKR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04732":null,"YKR036C":null},"has_protein_features":false,"name":"CAF4","ortholog_annotations":[{"gene_uniquename":"YKR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04732","reference_uniquename":"PMID:26896847"}],"product":"WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001744","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR036C"}


id: YKR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05266":null,"YKR037C":null},"has_protein_features":false,"name":"SPC34","ortholog_annotations":[{"gene_uniquename":"YKR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05266","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001745","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR037C"}


id: YKR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04182":null,"YKR038C":null},"has_protein_features":false,"name":"KAE1","ortholog_annotations":[{"gene_uniquename":"YKR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04182","reference_uniquename":"PMID:29761456"}],"product":"Highly conserved ATPase of HSP70/DnaK family; essential functional component of the EKC/KEOPS complex, with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001746","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR038C"}


id: YKR039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YKR039W":null},"has_protein_features":false,"name":"GAP1","ortholog_annotations":[{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"General amino acid permease; involved in uptake of all L-amino acids, some D-amino acids, related compounds, toxic analogs and polyamines; regulated by nitrogen source; targeted to vacuole for degradation under preferential nitrogen source; essential for invasive growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001747","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR039W"}


id: YKR040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W","secondary_identifier":"SGD:S000001748","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR040C"}


id: YKR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking","secondary_identifier":"SGD:S000001749","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR041W"}


id: YKR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02649":null,"SJAG_03295":null,"YKR042W":null},"has_protein_features":false,"name":"UTH1","ortholog_annotations":[{"gene_uniquename":"YKR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02649","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03295","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein; role in mitophagy is disputed; implicated in cell wall biogenesis, the oxidative stress response, life span during starvation, and cell death; SUN family member; UTH1 has a paralog, NCA3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001750","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR042W"}


id: YKR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SHB17","product":"Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus","secondary_identifier":"SGD:S000001751","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR043C"}


id: YKR044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01991":null,"YKR044W":null},"has_protein_features":false,"name":"UIP5","ortholog_annotations":[{"gene_uniquename":"YKR044W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01991","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function that interacts with Ulp1p; a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001752","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR044W"}


id: YKR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm","secondary_identifier":"SGD:S000001753","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR045C"}


id: YKR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PLN1","product":"Perilipin, involved in formation and stability of lipid droplets; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange","secondary_identifier":"SGD:S000001754","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR046C"}


id: YKR047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1","secondary_identifier":"SGD:S000001755","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR047W"}


id: YKR048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00942":null,"SJAG_02314":null,"YKR048C":null},"has_protein_features":false,"name":"NAP1","ortholog_annotations":[{"gene_uniquename":"YKR048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00942","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02314","reference_uniquename":"PMID:29761456"}],"product":"Histone chaperone and assembly chaperone for Rps6a/b; involved in histone exchange, replacing histone H2A-H2B dimers or histone variant dimers from assembled nucleosomes; promotes solubility of Rps6a, and 40S ribosomal subunit biogenesis; role in transport of H2A and H2B histones to the nucleus; regulates microtubule dynamics during mitosis; interacts with mitotic cyclin Clb2p; controls bud morphogenesis; phosphorylated by CK2; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001756","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR048C"}


id: YKR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FMP46","product":"Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000001757","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR049C"}


id: YKR050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01353":null,"SJAG_02883":null,"YKR050W":null},"has_protein_features":false,"name":"TRK2","ortholog_annotations":[{"gene_uniquename":"YKR050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01353","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02883","reference_uniquename":"PMID:29761456"}],"product":"Component of the Trk1p-Trk2p potassium transport system; contributes to K(+) supply and maintenance of plasma-membrane potential; TRK2 has a paralog, TRK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001758","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR050W"}


id: YKR051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03725":null,"YKR051W":null},"has_protein_features":false,"name":"HFL1","ortholog_annotations":[{"gene_uniquename":"YKR051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03725","reference_uniquename":"PMID:29761456"}],"product":"Vacuole membrane protein that interacts with Atg8p; functions in the vacuolar membrane recruitment of Atg8p to facilitate the degradation of vacuolar integral membrane proteins during early-stationary vacuole turnover (EVT), a general degradation process for vacuolar integral membrane proteins when cells enter stationary phase; null mutant is defective in stationary phase-induced vacuolar microdomain formation; homolog of S. pombe hfl1; homolog of human TMEM184","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001759","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR051W"}


id: YKR052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02473":null,"SJAG_04737":null,"YKR052C":null},"has_protein_features":false,"name":"MRS4","ortholog_annotations":[{"gene_uniquename":"YKR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02473","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04737","reference_uniquename":"PMID:29761456"}],"product":"Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001760","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR052C"}


id: YKR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04986":null,"YKR053C":null},"has_protein_features":false,"name":"YSR3","ortholog_annotations":[{"gene_uniquename":"YKR053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04986","reference_uniquename":"PMID:29761456"}],"product":"Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001761","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR053C"}


id: YKR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02286":null,"YKR054C":null},"has_protein_features":false,"name":"DYN1","ortholog_annotations":[{"gene_uniquename":"YKR054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02286","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001762","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR054C"}


id: YKR055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01774":null,"YKR055W":null},"has_protein_features":false,"name":"RHO4","ortholog_annotations":[{"gene_uniquename":"YKR055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01774","reference_uniquename":"PMID:29761456"}],"product":"Non-essential small GTPase; member of the Rho/Rac subfamily of Ras-like proteins; likely to be involved in the establishment of cell polarity; has long N-terminal extension that plays an important role in Rho4p function and is shared with Rho4 homologs in other yeasts and filamentous fungi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001763","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR055W"}


id: YKR056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04736":null,"YKR056W":null},"has_protein_features":false,"name":"TRM2","ortholog_annotations":[{"gene_uniquename":"YKR056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04736","reference_uniquename":"PMID:29761456"}],"product":"tRNA methyltransferase; 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001764","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR056W"}


id: YKR057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04174":null,"YKR057W":null},"has_protein_features":false,"name":"RPS21A","ortholog_annotations":[{"gene_uniquename":"YKR057W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04174","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001765","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR057W"}


id: YKR058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GLG1","product":"Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole respectively; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001766","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR058W"}


id: YKR059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04772":null,"YKR059W":null},"has_protein_features":false,"name":"TIF1","ortholog_annotations":[{"gene_uniquename":"YKR059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04772","reference_uniquename":"PMID:29761456"}],"product":"Translation initiation factor eIF4A; DEAD-box RNA helicase that couples ATPase activity to mRNA binding and unwinding; ATP hydrolysis accelerates the recruitment of mRNA during 48S preinitiation complex (PIC) assembly; ATPase activity stimulated by either eIF4G1 or by the PIC in an eIF3g and eIFGi subunit-dependent manner, independent of eIF4E and eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E and eIF4G; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001767","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR059W"}


id: YKR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01420":null,"SJAG_01752":null,"YKR060W":null},"has_protein_features":false,"name":"UTP30","ortholog_annotations":[{"gene_uniquename":"YKR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01420","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01752","reference_uniquename":"PMID:29761456"}],"product":"Subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit; Utp30p is peripherally associated with 90S preribosome and appears partially redundant with its paralog Cic1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001768","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR060W"}


id: YKR061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"YKR061W":null},"has_protein_features":false,"name":"KTR2","ortholog_annotations":[{"gene_uniquename":"YKR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"}],"product":"Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001769","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR061W"}


id: YKR062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00159":null,"YKR062W":null},"has_protein_features":false,"name":"TFA2","ortholog_annotations":[{"gene_uniquename":"YKR062W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00159","reference_uniquename":"PMID:29761456"}],"product":"TFIIE small subunit; involved in RNA polymerase II transcription initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001770","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR062W"}


id: YKR063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01581":null,"YKR063C":null},"has_protein_features":false,"name":"LAS1","ortholog_annotations":[{"gene_uniquename":"YKR063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01581","reference_uniquename":"PMID:29761456"}],"product":"Endonuclease involved in pre-rRNA processing at both ends of ITS2; functions with Grc3p in a conserved mechanism to cleave pre-rRNA at a specific site during rRNA processing and ribosome biogenesis; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S cell cycle transition; human ortholog is Las1L; mutants require the SSD1-v allele for viability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001771","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR063C"}


id: YKR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OAF3","product":"Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress","secondary_identifier":"SGD:S000001772","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR064W"}


id: YKR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04432":null,"YKR065C":null},"has_protein_features":false,"name":"PAM17","ortholog_annotations":[{"gene_uniquename":"YKR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04432","reference_uniquename":"PMID:29761456"}],"product":"Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001773","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR065C"}


id: YKR066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CCP1","product":"Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria; acts as hydrogen peroxide sensor in mitochondria, involved in the response to oxidative stress","secondary_identifier":"SGD:S000001774","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR066C"}


id: YKR067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02654":null,"SJAG_03305":null,"YKR067W":null},"has_protein_features":false,"name":"GPT2","ortholog_annotations":[{"gene_uniquename":"YKR067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02654","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03305","reference_uniquename":"PMID:26896847"}],"product":"Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001775","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR067W"}


id: YKR068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01415":null,"YKR068C":null},"has_protein_features":false,"name":"BET3","ortholog_annotations":[{"gene_uniquename":"YKR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01415","reference_uniquename":"PMID:29761456"}],"product":"Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); hydrophilic homodimeric protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001776","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR068C"}


id: YKR069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01192":null,"YKR069W":null},"has_protein_features":false,"name":"MET1","ortholog_annotations":[{"gene_uniquename":"YKR069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01192","reference_uniquename":"PMID:29761456"}],"product":"S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001777","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR069W"}


id: YKR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04317":null,"YKR070W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YKR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04317","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001778","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR070W"}


id: YKR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00455":null,"YKR071C":null},"has_protein_features":false,"name":"DRE2","ortholog_annotations":[{"gene_uniquename":"YKR071C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00455","reference_uniquename":"PMID:29761456"}],"product":"Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18p in an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress; inviability of the null mutant is functionally complemented by human CIAPIN1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001779","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR071C"}


id: YKR072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SIS2","product":"Negative regulatory subunit of protein phosphatase 1 (Ppz1p); involved in coenzyme A biosynthesis; subunit of phosphopantothenoylcysteine decarboxylase (PPCDC: Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p); SIS2 has a paralog, VHS3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001780","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR072C"}


id: YKR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000001781","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR073C"}


id: YKR074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04741":null,"YKR074W":null},"has_protein_features":false,"name":"AIM29","ortholog_annotations":[{"gene_uniquename":"YKR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04741","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001782","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR074W"}


id: YKR075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; similar to Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; YKR075C has a paralog, YOR062C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001783","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR075C"}


id: YKR075W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a protein; completely overlaps the uncharacterized gene YKR075C; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR075W-A"}


id: YKR076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ECM4","product":"S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR); glutathione transferase involved in cell-surface biosynthesis and architecture; catalyzes glutathione (GSH)-dependent reduction of GS-trichloro-p-hydroquinone to trichloro-p-hydroquinone; expression upregulated upon exposure to genotoxic agents, such as methyl methanesulfonate, cisplatin and bleomycin; not an essential gene; similar to YGR154C; green fluorescent protein (GFP)-fusion protein localizes to cytoplasm","secondary_identifier":"SGD:S000001784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR076W"}


id: YKR077W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MSA2","product":"Putative transcriptional activator; interacts with G1-specific transcription factor MBF and G1-specific promoters; MSA2 has a paralog, MSA1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001785","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR077W"}


id: YKR078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Cytoplasmic protein of unknown function; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P); YKR078W has a paralog, VPS5, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001786","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR078W"}


id: YKR079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00997":null,"SJAG_04885":null,"YKR079C":null},"has_protein_features":false,"name":"TRZ1","ortholog_annotations":[{"gene_uniquename":"YKR079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00997","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04885","reference_uniquename":"PMID:29761456"}],"product":"tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001787","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR079C"}


id: YKR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01126":null,"YKR080W":null},"has_protein_features":false,"name":"MTD1","ortholog_annotations":[{"gene_uniquename":"YKR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01126","reference_uniquename":"PMID:29761456"}],"product":"NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase; plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001788","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR080W"}


id: YKR081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04108":null,"YKR081C":null},"has_protein_features":false,"name":"RPF2","ortholog_annotations":[{"gene_uniquename":"YKR081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04108","reference_uniquename":"PMID:29761456"}],"product":"Essential protein involved in rRNA maturation and ribosomal assembly; involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001789","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR081C"}


id: YKR082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01374":null,"SJAG_03986":null,"YKR082W":null},"has_protein_features":false,"name":"NUP133","ortholog_annotations":[{"gene_uniquename":"YKR082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01374","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03986","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Nup84p subcomplex of nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis; is involved in establishment of a normal nucleocytoplasmic concentration gradient of GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at nuclear periphery, including double-strand break repair, transcription and chromatin silencing; relocalizes to cytosol in response to hypoxia; homolog of human NUP133","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001790","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR082W"}


id: YKR083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01371":null,"YKR083C":null},"has_protein_features":false,"name":"DAD2","ortholog_annotations":[{"gene_uniquename":"YKR083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01371","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001791","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR083C"}


id: YKR084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02601":null,"YKR084C":null},"has_protein_features":false,"name":"HBS1","ortholog_annotations":[{"gene_uniquename":"YKR084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02601","reference_uniquename":"PMID:29761456"}],"product":"GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, particularly in 3' UTRs; genetically implicated in mRNA no-go decay; HBS1 has a paralog, SKI7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001792","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR084C"}


id: YKR085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04244":null,"YKR085C":null},"has_protein_features":false,"name":"MRPL20","ortholog_annotations":[{"gene_uniquename":"YKR085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04244","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001793","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR085C"}


id: YKR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01152":null,"YKR086W":null},"has_protein_features":false,"name":"PRP16","ortholog_annotations":[{"gene_uniquename":"YKR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01152","reference_uniquename":"PMID:29761456"}],"product":"DEAH-box RNA helicase; involved in the second catalytic step of splicing and in exon ligation; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step; missense mutation in human ortholog DHX38 associated with early-onset retinitis pigmentosa","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001794","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR086W"}


id: YKR087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04514":null,"YKR087C":null},"has_protein_features":false,"name":"OMA1","ortholog_annotations":[{"gene_uniquename":"YKR087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04514","reference_uniquename":"PMID:29761456"}],"product":"Metalloendopeptidase of the mitochondrial inner membrane; important for adaptive responses to various homeostatic insults, preservation of normal mitochondrial function under damage-eliciting conditions, and stability of respiratory supercomplexes; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; zebrafish ortholog has a role in organ development and mouse ortholog is also required for respiratory supercomplex stability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001795","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR087C"}


id: YKR088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01133":null,"YKR088C":null},"has_protein_features":false,"name":"TVP38","ortholog_annotations":[{"gene_uniquename":"YKR088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01133","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001796","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR088C"}


id: YKR089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02089":null,"SJAG_02907":null,"YKR089C":null},"has_protein_features":false,"name":"TGL4","ortholog_annotations":[{"gene_uniquename":"YKR089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02089","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02907","reference_uniquename":"PMID:29761456"}],"product":"Multifunctional lipase/hydrolase/phospholipase; triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p; TGL4 has a paralog, TGL5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001797","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR089C"}


id: YKR090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02831":null,"YKR090W":null},"has_protein_features":false,"name":"PXL1","ortholog_annotations":[{"gene_uniquename":"YKR090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02831","reference_uniquename":"PMID:29761456"}],"product":"Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001798","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR090W"}


id: YKR091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SRL3","product":"Repressor of transcription at Start; binds to SBF (Swi4p-Swi6p) at SCB promoter elements in G1 to repress transcription; inhibitor of Start that retains Cdc28-Cln3 at the ER; acts with Ydj1p to promote release of the complex in a growth-mediated positive feedback loop to trigger Start; Srl3p is unstable and degraded by SCF-Grr1 after Cdc28p-dependent phosphorylation; contains a GTB (G1/S transcription factor binding) motif; binds SBF-regulated promoters in HU-treated cells; Cdc28p substrate","secondary_identifier":"SGD:S000001799","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR091W"}


id: YKR092C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01125":null,"YKR092C":null},"has_protein_features":false,"name":"SRP40","ortholog_annotations":[{"gene_uniquename":"YKR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01125","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar serine-rich protein; role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001800","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR092C"}


id: YKR093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01983":null,"YKR093W":null},"has_protein_features":false,"name":"PTR2","ortholog_annotations":[{"gene_uniquename":"YKR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01983","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001801","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR093W"}


id: YKR094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01365":null,"SJAG_02891":null,"SJAG_03971":null,"YKR094C":null},"has_protein_features":false,"name":"RPL40B","ortholog_annotations":[{"gene_uniquename":"YKR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01365","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02891","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03971","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001802","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR094C"}


id: YKR095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03300":null,"SJAG_04645":null,"YKR095W":null},"has_protein_features":false,"name":"MLP1","ortholog_annotations":[{"gene_uniquename":"YKR095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03300","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YKR095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04645","reference_uniquename":"PMID:29761456"}],"product":"Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs; MLP1 has a paralog, MLP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001803","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR095W"}


id: YKR095W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02863":null,"YKR095W-A":null},"has_protein_features":false,"name":"PCC1","ortholog_annotations":[{"gene_uniquename":"YKR095W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02863","reference_uniquename":"PMID:29761456"}],"product":"Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; other complex members are Kae1p, Gon7p, Bud32p, and Cgi121p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028512","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR095W-A"}


id: YKR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ESL2","product":"hEST1A/B (SMG5/6)-like protein; contributes to environment-sensing adaptive gene expression responses; Esl2p and Esl1p contain a 14-3-3-like domain and a putative PilT N-terminus ribonuclease domain; interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; ESL2 has a paralog, ESL1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001804","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR096W"}


id: YKR097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PCK1","product":"Phosphoenolpyruvate carboxykinase; key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol","secondary_identifier":"SGD:S000001805","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR097W"}


id: YKR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"UBP11","product":"Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; UBP11 has a paralog, UBP7, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR098C"}


id: YKR099C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a protein; YKR099C-A was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YKR100C","secondary_identifier":"SGD:S000028842","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR099C-A"}


id: YKR099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BAS1","product":"Myb-related transcription factor; involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes","secondary_identifier":"SGD:S000001807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR099W"}


id: YKR100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SKG1","product":"Transmembrane protein with a role in cell wall polymer composition; localizes on inner surface of plasma membrane at bud and in daughter cell; SKG1 has a paralog, AIM20, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR100C"}


id: YKR101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SIR1","product":"Protein involved in silencing at mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin","secondary_identifier":"SGD:S000001809","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR101W"}


id: YKR102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FLO10","product":"Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth","secondary_identifier":"SGD:S000001810","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR102W"}


id: YKR103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NFT1","product":"Putative transporter of the MRP subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; MRP stands for multidrug resistance-associated protein","secondary_identifier":"SGD:S000001811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR103W"}


id: YKR104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative transporter of the MRP subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; MRP stands for multidrug resistance-associated protein","secondary_identifier":"SGD:S000001812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR104W"}


id: YKR105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01336":null,"SJAG_01636":null,"SJAG_01923":null,"SJAG_04983":null,"YKR105C":null},"has_protein_features":false,"name":"VBA5","ortholog_annotations":[{"gene_uniquename":"YKR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01336","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01636","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01923","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04983","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; VBA5 has a paralog, VBA3, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001813","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR105C"}


id: YKR106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YKR106W":null},"has_protein_features":false,"name":"GEX2","ortholog_annotations":[{"gene_uniquename":"YKR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; expressed at a very low level; potential role in resistance to oxidative stress and modulation of the PKA pathway; GEX2 has a paralog, GEX1, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001814","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR106W"}


id: YLL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02848":null,"YLL001W":null},"has_protein_features":false,"name":"DNM1","ortholog_annotations":[{"gene_uniquename":"YLL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02848","reference_uniquename":"PMID:29761456"}],"product":"Dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and inheritance; self assembles on the cytoplasmic face of mitochondrial tubules at sites where division will occur; participates in endocytosis and regulates peroxisome fission along with Vps1p; mutants in the human ortholog DNM1L, which mediates mitochondrial fission, peroxisomal division, autophagy, and mitophagy, are associated with slowly progressive infantile encephalopathy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003924","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL001W"}


id: YLL002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01204":null,"YLL002W":null},"has_protein_features":false,"name":"RTT109","ortholog_annotations":[{"gene_uniquename":"YLL002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01204","reference_uniquename":"PMID:29761456"}],"product":"Histone acetyltransferase; critical for cell survival in presence of DNA damage during S phase, required for recovery after DSB repair; acetylates H3K56, H3K9; H3K56 acetylation activity required for expression homeostasis, buffering of mRNA synthesis rate against changes in gene dosage during S phase; involved in non-homologous end joining and regulation of Ty1 transposition; prevents hyper-amplification of rDNA; interacts physically with Vps75p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003925","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL002W"}


id: YLL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03544":null,"YLL003W":null},"has_protein_features":false,"name":"SFI1","ortholog_annotations":[{"gene_uniquename":"YLL003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03544","reference_uniquename":"PMID:29761456"}],"product":"Centrin (Cdc31p)-binding protein required for SPB duplication; localizes to the half-bridge of the spindle pole body (SPB); required for progression through G(2)-M transition; phosphorylated by Cdc28p-Clb2p and by Cdc5p; dephosphorylated by Cdc14p; has similarity to Xenopus laevis XCAP-C","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003926","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL003W"}


id: YLL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05301":null,"YLL004W":null},"has_protein_features":false,"name":"ORC3","ortholog_annotations":[{"gene_uniquename":"YLL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05301","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003927","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL004W"}


id: YLL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPO75","product":"Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis","secondary_identifier":"SGD:S000003928","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL005C"}


id: YLL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04370":null,"YLL006W":null},"has_protein_features":false,"name":"MMM1","ortholog_annotations":[{"gene_uniquename":"YLL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04370","reference_uniquename":"PMID:29761456"}],"product":"ER integral membrane protein, ERMES complex subunit; ERMES links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003929","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL006W"}


id: YLL006W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028560","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL006W-A"}


id: YLL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LMO1","product":"Homolog of mammalian ELMO (Engulfment and celL MOtility); upstream component for regulation through the small GTPase Rho5p; may form a complex with Dck1p that acts as a GEF for Rho5p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein","secondary_identifier":"SGD:S000003930","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL007C"}


id: YLL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03730":null,"YLL008W":null},"has_protein_features":false,"name":"DRS1","ortholog_annotations":[{"gene_uniquename":"YLL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03730","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar DEAD-box protein required for ribosome assembly and function; including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003931","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL008W"}


id: YLL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00449":null,"YLL009C":null},"has_protein_features":false,"name":"COX17","ortholog_annotations":[{"gene_uniquename":"YLL009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00449","reference_uniquename":"PMID:29761456"}],"product":"Copper metallochaperone that transfers copper to Sco1p and Cox11p; eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs; interacts with the MICOS complex, and interaction is promoted by copper ions; human homolog COX17 partially complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003932","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL009C"}


id: YLL010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02389":null,"SJAG_04128":null,"YLL010C":null},"has_protein_features":false,"name":"PSR1","ortholog_annotations":[{"gene_uniquename":"YLL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02389","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04128","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane-associated protein phosphatase; involved in the general stress response and the inactivating dephosphorylation of Mep2p; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through Msn2p dephosphorylation, and for inhibition of TORC1 in response to limiting amino acids; regulates the sodium ion stress response with Psr2p; member of the HAD family of protein phosphatases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003933","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL010C"}


id: YLL011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03569":null,"YLL011W":null},"has_protein_features":false,"name":"SOF1","ortholog_annotations":[{"gene_uniquename":"YLL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03569","reference_uniquename":"PMID:29761456"}],"product":"Protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003934","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL011W"}


id: YLL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YEH1","product":"Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes; YEH1 has a paralog, YEH2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003935","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL012W"}


id: YLL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00686":null,"SJAG_00759":null,"SJAG_02036":null,"YLL013C":null},"has_protein_features":false,"name":"PUF3","ortholog_annotations":[{"gene_uniquename":"YLL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00686","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00759","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02036","reference_uniquename":"PMID:29761456"}],"product":"Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochondria during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins; translationally represses oxidative stress-linked genes; regulates CoQ biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003936","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL013C"}


id: YLL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04294":null,"YLL014W":null},"has_protein_features":false,"name":"EMC6","ortholog_annotations":[{"gene_uniquename":"YLL014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04294","reference_uniquename":"PMID:29761456"}],"product":"Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003937","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL014W"}


id: YLL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01344":null,"SJAG_03785":null,"SJAG_05213":null,"YLL015W":null},"has_protein_features":false,"name":"BPT1","ortholog_annotations":[{"gene_uniquename":"YLL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01344","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03785","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05213","reference_uniquename":"PMID:29761456"}],"product":"ABC type transmembrane transporter of MRP/CFTR family; found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003938","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL015W"}


id: YLL018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01197":null,"YLL018C":null},"has_protein_features":false,"name":"DPS1","ortholog_annotations":[{"gene_uniquename":"YLL018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01197","reference_uniquename":"PMID:29761456"}],"product":"Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation; shares five highly conserved amino acids with human that when mutated cause leukoencephalopathy characterized by hypomyelination with brain stem and spinal cord involvement and leg spasticity (HBSL)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003941","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL018C"}


id: YLL018C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01996":null,"YLL018C-A":null},"has_protein_features":false,"name":"COX19","ortholog_annotations":[{"gene_uniquename":"YLL018C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01996","reference_uniquename":"PMID:29761456"}],"product":"Protein required for cytochrome c oxidase assembly; located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL018C-A"}


id: YLL019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00996":null,"YLL019C":null},"has_protein_features":false,"name":"KNS1","ortholog_annotations":[{"gene_uniquename":"YLL019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00996","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003942","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL019C"}


id: YLL019W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene KNS1","secondary_identifier":"SGD:S000028670","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL019W-A"}


id: YLL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1","secondary_identifier":"SGD:S000003943","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL020C"}


id: YLL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03625":null,"YLL021W":null},"has_protein_features":false,"name":"SPA2","ortholog_annotations":[{"gene_uniquename":"YLL021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03625","reference_uniquename":"PMID:29761456"}],"product":"Component of the polarisome; functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate; coding sequence contains length polymorphisms in different strains; SPA2 has a paralog, SPH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003944","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL021W"}


id: YLL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04547":null,"YLL022C":null},"has_protein_features":false,"name":"HIF1","ortholog_annotations":[{"gene_uniquename":"YLL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04547","reference_uniquename":"PMID:29761456"}],"product":"Non-essential component of the HAT-B histone acetyltransferase complex; localized to the nucleus; has a role in telomeric silencing; other members are Hat1p and Hat2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003945","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL022C"}


id: YLL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01460":null,"YLL023C":null},"has_protein_features":false,"name":"POM33","ortholog_annotations":[{"gene_uniquename":"YLL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01460","reference_uniquename":"PMID:29761456"}],"product":"Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003946","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL023C"}


id: YLL024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01186":null,"SJAG_04055":null,"YLL024C":null},"has_protein_features":false,"name":"SSA2","ortholog_annotations":[{"gene_uniquename":"YLL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01186","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04055","reference_uniquename":"PMID:29761456"}],"product":"HSP70 family ATP-binding protein; involved in protein folding, vacuolar import of proteins; required for ubiquitin-dependent degradation of short-lived proteins; associated with chaperonin-containing T-complex; 98% identical to paralog Ssa1p with distinct functional specificity in propagation of yeast [URE3] prions and vacuolar-mediated degradation of gluconeogenesis enzymes; binds tRNA, has role in tRNA nuclear import during starvation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003947","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL024C"}


id: YLL025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU17","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; YLL025W is not an essential gene","secondary_identifier":"SGD:S000003948","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL025W"}


id: YLL026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04187":null,"YLL026W":null},"has_protein_features":false,"name":"HSP104","ortholog_annotations":[{"gene_uniquename":"YLL026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04187","reference_uniquename":"PMID:29761456"}],"product":"Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responds to stresses including heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; potentiated Hsp104p variants decrease TDP-43 proteotoxicity by eliminating its cytoplasmic aggregation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003949","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL026W"}


id: YLL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03701":null,"YLL027W":null},"has_protein_features":false,"name":"ISA1","ortholog_annotations":[{"gene_uniquename":"YLL027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03701","reference_uniquename":"PMID:29761456"}],"product":"Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins; human ISCA1 can complement isa1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003950","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL027W"}


id: YLL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02059":null,"SJAG_02060":null,"YLL028W":null},"has_protein_features":false,"name":"TPO1","ortholog_annotations":[{"gene_uniquename":"YLL028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02059","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02060","reference_uniquename":"PMID:29761456"}],"product":"Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003951","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL028W"}


id: YLL029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00969":null,"YLL029W":null},"has_protein_features":false,"name":"FRA1","ortholog_annotations":[{"gene_uniquename":"YLL029W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00969","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003952","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL029W"}


id: YLL030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RRT7","product":"Putative protein of unknown function; conserved across S. cerevisiae strains; identified in a screen for mutants with increased levels of rDNA transcription","secondary_identifier":"SGD:S000003953","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL030C"}


id: YLL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03506":null,"YLL031C":null},"has_protein_features":false,"name":"GPI13","ortholog_annotations":[{"gene_uniquename":"YLL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03506","reference_uniquename":"PMID:29761456"}],"product":"ER membrane localized phosphoryltransferase; adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003954","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL031C"}


id: YLL032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04521":null,"YLL032C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLL032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04521","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003955","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL032C"}


id: YLL033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IRC19","product":"Protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci","secondary_identifier":"SGD:S000003956","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL033W"}


id: YLL034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04599":null,"YLL034C":null},"has_protein_features":false,"name":"RIX7","ortholog_annotations":[{"gene_uniquename":"YLL034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04599","reference_uniquename":"PMID:29761456"}],"product":"Putative ATPase of the AAA family; required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003957","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL034C"}


id: YLL035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03789":null,"YLL035W":null},"has_protein_features":false,"name":"GRC3","ortholog_annotations":[{"gene_uniquename":"YLL035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03789","reference_uniquename":"PMID:29761456"}],"product":"Polynucleotide kinase present on rDNA; required for efficient transcription termination by RNA polymerase I; functions with Las1p in a conserved mechanism to cleave pre-rRNA at a specific site during rRNA processing and ribosome biogenesis; required for cell growth; mRNA is cell-cycle regulated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003958","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL035W"}


id: YLL036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04783":null,"YLL036C":null},"has_protein_features":false,"name":"PRP19","ortholog_annotations":[{"gene_uniquename":"YLL036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04783","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003959","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL036C"}


id: YLL037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor","secondary_identifier":"SGD:S000003960","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL037W"}


id: YLL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04644":null,"YLL038C":null},"has_protein_features":false,"name":"ENT4","ortholog_annotations":[{"gene_uniquename":"YLL038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04644","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003961","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL038C"}


id: YLL039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00452":null,"YLL039C":null},"has_protein_features":false,"name":"UBI4","ortholog_annotations":[{"gene_uniquename":"YLL039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00452","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via ubiquitin-26S proteasome system; essential for cellular stress response; encoded as polyubiquitin precursor comprised of 5 head-to-tail repeats; number of repeats is evolutionarily unstable within and between yeast species; protein abundance increases in response to DNA replication stress; implicated as modulator of replicative lifespan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003962","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL039C"}


id: YLL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01229":null,"SJAG_16459":null,"YLL040C":null},"has_protein_features":false,"name":"VPS13","ortholog_annotations":[{"gene_uniquename":"YLL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01229","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16459","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in prospore membrane morphogenesis; peripheral membrane protein that localizes to the prospore membrane and at numerous membrane contact sites; involved in sporulation, vacuolar protein sorting, prospore membrane formation during sporulation, and protein-Golgi retention; required for mitochondrial integrity; contains a PH-like domain; homologous to human CHAC and COH1 which are involved in Chorea-acanthocytosis and Cohen syndrome, respectively","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003963","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL040C"}


id: YLL041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00260":null,"YLL041C":null},"has_protein_features":false,"name":"SDH2","ortholog_annotations":[{"gene_uniquename":"YLL041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00260","reference_uniquename":"PMID:29761456"}],"product":"Iron-sulfur protein subunit of succinate dehydrogenase; the complex couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; other members are Sdh1p, Sdh3p, and Sdh4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003964","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL041C"}


id: YLL042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01251":null,"YLL042C":null},"has_protein_features":false,"name":"ATG10","ortholog_annotations":[{"gene_uniquename":"YLL042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01251","reference_uniquename":"PMID:29761456"}],"product":"Conserved E2-like conjugating enzyme; mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003965","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL042C"}


id: YLL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FPS1","product":"Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in transport of acetate, arsenite, and antimonite; key factor in maintaining redox balance by mediating passive diffusion of glycerol; phosphorylated by Hog1p and Slt2p MAPK; deletion improves xylose fermentation; regulated by Rgc1p and Ask10p, which are regulated by Hog1p phosphorylation under osmotic stress; phosphorylation by Ypk1p required to maintain an open state","secondary_identifier":"SGD:S000003966","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL043W"}


id: YLL044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant","secondary_identifier":"SGD:S000003967","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL044W"}


id: YLL045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00537":null,"YLL045C":null},"has_protein_features":false,"name":"RPL8B","ortholog_annotations":[{"gene_uniquename":"YLL045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00537","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB during assembly of large subunit; binds Domain I of 25S, 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; RPL8B has paralog RPL8A from whole genome duplication; RPL8A or RPL8B ribosomes not functionally interchangeable; proportions of Rpl8ap, Rpl8bp in 80S ribosome differ in glucose and glycerol; homologous to mammalian ribosomal protein L7A, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003968","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL045C"}


id: YLL046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04863":null,"YLL046C":null},"has_protein_features":false,"name":"RNP1","ortholog_annotations":[{"gene_uniquename":"YLL046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04863","reference_uniquename":"PMID:29761456"}],"product":"Ribonucleoprotein that contains two RNA recognition motifs (RRM); RNP1 has a paralog, SBP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003969","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL046C"}


id: YLL047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1","secondary_identifier":"SGD:S000003970","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL047W"}


id: YLL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01344":null,"SJAG_03785":null,"SJAG_05213":null,"YLL048C":null},"has_protein_features":false,"name":"YBT1","ortholog_annotations":[{"gene_uniquename":"YLL048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01344","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03785","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05213","reference_uniquename":"PMID:29761456"}],"product":"Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003971","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL048C"}


id: YLL049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LDB18","product":"Component of the dynactin complex; dynactin is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24","secondary_identifier":"SGD:S000003972","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL049W"}


id: YLL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03025":null,"YLL050C":null},"has_protein_features":false,"name":"COF1","ortholog_annotations":[{"gene_uniquename":"YLL050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03025","reference_uniquename":"PMID:29761456"}],"product":"Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003973","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL050C"}


id: YLL051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04743":null,"YLL051C":null},"has_protein_features":false,"name":"FRE6","ortholog_annotations":[{"gene_uniquename":"YLL051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003974","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL051C"}


id: YLL052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AQY2","product":"Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains","secondary_identifier":"SGD:S000003975","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL052C"}


id: YLL053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin","secondary_identifier":"SGD:S000003976","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL053C"}


id: YLL054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function with similarity to Pip2p; an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene","secondary_identifier":"SGD:S000003977","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL054C"}


id: YLL055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04295":null,"YLL055W":null},"has_protein_features":false,"name":"YCT1","ortholog_annotations":[{"gene_uniquename":"YLL055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04295","reference_uniquename":"PMID:29761456"}],"product":"High-affinity cysteine-specific transporter; has similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003978","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL055W"}


id: YLL056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"NADH-dependent aldehyde reductase; reduces many aldehyde compounds including glycolaldehyde, formaldehyde and furfural; transcription unregulated by furfural, 5-hydroxymethylfurfural (HMF) and the mycotoxin patulin; expression increased by multidrug resistance transcription factors Yrm1p and Yrr1p; member of atypical subgroup 7 of the short-chain dehydrogenase/reductase (SDR) family; localizes to the cytoplasm; SWAT-GFP and mCherry fusion proteins localize to the ER and vacuole respectively","secondary_identifier":"SGD:S000003979","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL056C"}


id: YLL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"JLP1","product":"Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation","secondary_identifier":"SGD:S000003980","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL057C"}


id: YLL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03102":null,"YLL058W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03102","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function with similarity to Str2p; Str2p is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003981","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL058W"}


id: YLL059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003982","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL059C"}


id: YLL060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GTT2","product":"Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003983","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL060C"}


id: YLL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MMP1","product":"High-affinity S-methylmethionine permease; required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p","secondary_identifier":"SGD:S000003984","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL061W"}


id: YLL062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04425":null,"YLL062C":null},"has_protein_features":false,"name":"MHT1","ortholog_annotations":[{"gene_uniquename":"YLL062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04425","reference_uniquename":"PMID:29761456"}],"product":"S-methylmethionine-homocysteine methyltransferase; functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003985","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL062C"}


id: YLL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00020":null,"SJAG_00021":null,"SJAG_00075":null,"SJAG_01363":null,"SJAG_02126":null,"SJAG_02127":null,"SJAG_02940":null,"YLL063C":null},"has_protein_features":false,"name":"AYT1","ortholog_annotations":[{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00020","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00021","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00075","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01363","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02126","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02127","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02940","reference_uniquename":"PMID:26896847"}],"product":"Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000003986","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL063C"}


id: YLL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU18","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau6p","secondary_identifier":"SGD:S000003987","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL064C"}


id: YLL065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps chromosome XII telomeric element core sequences","secondary_identifier":"SGD:S000003988","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL065W"}


id: YLL066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative Y' element ATP-dependent helicase; YLL066C is not an essential gene","secondary_identifier":"SGD:S000003989","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL066C"}


id: YLL066W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YLL066C","secondary_identifier":"SGD:S000028671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL066W-A"}


id: YLL066W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; overexpression causes a cell cycle delay or arrest","secondary_identifier":"SGD:S000028672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL066W-B"}


id: YLL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative Y' element ATP-dependent helicase","secondary_identifier":"SGD:S000003990","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL067C"}


id: YLL067W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps YLL067C","secondary_identifier":"SGD:S000028673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL067W-A"}


id: YLR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00732":null,"YLR001C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00732","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003991","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR001C"}


id: YLR002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00311":null,"YLR002C":null},"has_protein_features":false,"name":"NOC3","ortholog_annotations":[{"gene_uniquename":"YLR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00311","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003992","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR002C"}


id: YLR003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01115":null,"YLR003C":null},"has_protein_features":false,"name":"CMS1","ortholog_annotations":[{"gene_uniquename":"YLR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01115","reference_uniquename":"PMID:29761456"}],"product":"Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003993","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR003C"}


id: YLR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02139":null,"SJAG_05182":null,"YLR004C":null},"has_protein_features":false,"name":"THI73","ortholog_annotations":[{"gene_uniquename":"YLR004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02139","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05182","reference_uniquename":"PMID:29761456"}],"product":"Putative plasma membrane permease; proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003994","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR004C"}


id: YLR005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00758":null,"YLR005W":null},"has_protein_features":false,"name":"SSL1","ortholog_annotations":[{"gene_uniquename":"YLR005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00758","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the core form of RNA polymerase transcription factor TFIIH; has both protein kinase and DNA-dependent ATPase/helicase activities; essential for transcription and nucleotide excision repair; interacts with Tfb4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003995","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR005W"}


id: YLR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00318":null,"YLR006C":null},"has_protein_features":false,"name":"SSK1","ortholog_annotations":[{"gene_uniquename":"YLR006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00318","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic phosphorelay intermediate osmosensor and regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003996","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR006C"}


id: YLR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05323":null,"YLR007W":null},"has_protein_features":false,"name":"NSE1","ortholog_annotations":[{"gene_uniquename":"YLR007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05323","reference_uniquename":"PMID:29761456"}],"product":"Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003997","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR007W"}


id: YLR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01597":null,"YLR008C":null},"has_protein_features":false,"name":"PAM18","ortholog_annotations":[{"gene_uniquename":"YLR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01597","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the import motor (PAM complex); the PAM complex is a  component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003998","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR008C"}


id: YLR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04395":null,"YLR009W":null},"has_protein_features":false,"name":"RLP24","ortholog_annotations":[{"gene_uniquename":"YLR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04395","reference_uniquename":"PMID:29761456"}],"product":"Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003999","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR009W"}


id: YLR010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04245":null,"YLR010C":null},"has_protein_features":false,"name":"TEN1","ortholog_annotations":[{"gene_uniquename":"YLR010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04245","reference_uniquename":"PMID:29761456"}],"product":"Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p; similar to human Ten1 which is critical for the telomeric function of the CST (Cdc13p-Stn1p-Ten1p) complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004000","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR010C"}


id: YLR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LOT6","product":"FMN-dependent NAD(P)H:quinone reductase; role in apoptosis-like cell death; may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions","secondary_identifier":"SGD:S000004001","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR011W"}


id: YLR012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YLR012C is not an essential gene","secondary_identifier":"SGD:S000004002","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR012C"}


id: YLR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GAT3","product":"Protein containing GATA family zinc finger motifs; involved in spore wall assembly; sequence similarity to GAT4, and the double mutant gat3 gat4 exhibits reduced dityrosine fluorescence relative to the single mutants","secondary_identifier":"SGD:S000004003","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR013W"}


id: YLR014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PPR1","product":"Zinc finger transcription factor; contains a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p","secondary_identifier":"SGD:S000004004","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR014C"}


id: YLR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00896":null,"YLR015W":null},"has_protein_features":false,"name":"BRE2","ortholog_annotations":[{"gene_uniquename":"YLR015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00896","reference_uniquename":"PMID:29761456"}],"product":"Subunit of COMPASS (Set1C) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004005","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR015W"}


id: YLR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PML1","product":"Subunit of the RES complex; RES complex is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p","secondary_identifier":"SGD:S000004006","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR016C"}


id: YLR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03881":null,"YLR017W":null},"has_protein_features":false,"name":"MEU1","ortholog_annotations":[{"gene_uniquename":"YLR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03881","reference_uniquename":"PMID:29761456"}],"product":"Methylthioadenosine phosphorylase (MTAP); catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004007","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR017W"}


id: YLR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03281":null,"YLR018C":null},"has_protein_features":false,"name":"POM34","ortholog_annotations":[{"gene_uniquename":"YLR018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03281","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004008","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR018C"}


id: YLR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02389":null,"SJAG_04128":null,"YLR019W":null},"has_protein_features":false,"name":"PSR2","ortholog_annotations":[{"gene_uniquename":"YLR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02389","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04128","reference_uniquename":"PMID:29761456"}],"product":"Putative plasma membrane phosphatase; involved in the general stress response and inactivating dephosphorylation of Mep2p; required along with Psr1p and binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through Msn2p dephosphorylation, and for inhibition of TORC1 in response to limiting amino acids; regulates the sodium ion stress response with Psr1p; member of the HAD family of protein phosphatases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004009","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR019W"}


id: YLR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YEH2","product":"Steryl ester hydrolase; catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; YEH2 has a paralog, YEH1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004010","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR020C"}


id: YLR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04602":null,"YLR021W":null},"has_protein_features":false,"name":"IRC25","ortholog_annotations":[{"gene_uniquename":"YLR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04602","reference_uniquename":"PMID:29761456"}],"product":"Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004011","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR021W"}


id: YLR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04491":null,"YLR022C":null},"has_protein_features":false,"name":"SDO1","ortholog_annotations":[{"gene_uniquename":"YLR022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04491","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF) for Ria1p; essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004012","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR022C"}


id: YLR023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02080":null,"YLR023C":null},"has_protein_features":false,"name":"IZH3","ortholog_annotations":[{"gene_uniquename":"YLR023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02080","reference_uniquename":"PMID:29761456"}],"product":"Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004013","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR023C"}


id: YLR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01253":null,"SJAG_04619":null,"YLR024C":null},"has_protein_features":false,"name":"UBR2","ortholog_annotations":[{"gene_uniquename":"YLR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01253","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04619","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic ubiquitin-protein ligase (E3); component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex required for the ubiquitination and degradation of Rpn4p; mediates formation of the ternary complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004014","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR024C"}


id: YLR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01242":null,"YLR025W":null},"has_protein_features":false,"name":"SNF7","ortholog_annotations":[{"gene_uniquename":"YLR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01242","reference_uniquename":"PMID:29761456"}],"product":"One of four subunits of the ESCRT-III complex; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes; ESCRT-III stands for endosomal sorting complex required for transport III","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004015","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR025W"}


id: YLR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03552":null,"YLR026C":null},"has_protein_features":false,"name":"SED5","ortholog_annotations":[{"gene_uniquename":"YLR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03552","reference_uniquename":"PMID:29761456"}],"product":"cis-Golgi t-SNARE syntaxin; required for vesicular transport between the ER and the Golgi complex; binds at least 9 SNARE proteins; plays a role in autophagy by regulating formation of autophagic vesicles in Golgi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004016","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR026C"}


id: YLR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03306":null,"YLR027C":null},"has_protein_features":false,"name":"AAT2","ortholog_annotations":[{"gene_uniquename":"YLR027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03306","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004017","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR027C"}


id: YLR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04681":null,"YLR028C":null},"has_protein_features":false,"name":"ADE16","ortholog_annotations":[{"gene_uniquename":"YLR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04681","reference_uniquename":"PMID:29761456"}],"product":"Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004018","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR028C"}


id: YLR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03919":null,"SJAG_04478":null,"YLR029C":null},"has_protein_features":false,"name":"RPL15A","ortholog_annotations":[{"gene_uniquename":"YLR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03919","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04478","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004019","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR029C"}


id: YLR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W","secondary_identifier":"SGD:S000004020","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR030W"}


id: YLR031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W; YLR031W has a paralog, YMR124W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004021","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR031W"}


id: YLR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02521":null,"YLR032W":null},"has_protein_features":false,"name":"RAD5","ortholog_annotations":[{"gene_uniquename":"YLR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02521","reference_uniquename":"PMID:29761456"}],"product":"DNA helicase/Ubiquitin ligase; involved in error-free DNA damage tolerance (DDT), replication fork regression during postreplication repair by template switching, and error-prone translesion synthesis; required for UV and MMS-associated unequal sister chromatid exchange (SCE) but not for double-strand break associated unequal SCE; promotes synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; human homolog HLTF can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004022","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR032W"}


id: YLR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03758":null,"YLR033W":null},"has_protein_features":false,"name":"RSC58","ortholog_annotations":[{"gene_uniquename":"YLR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03758","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004023","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR033W"}


id: YLR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01007":null,"YLR034C":null},"has_protein_features":false,"name":"SMF3","ortholog_annotations":[{"gene_uniquename":"YLR034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01007","reference_uniquename":"PMID:29761456"}],"product":"Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004024","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR034C"}


id: YLR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MLH2","product":"Protein involved in mismatch repair and meiotic recombination; only certain frameshift intermediates are mismatch repair substrates; forms a complex with Mlh1p, plays accessory role in stimulating activity of MLH1/PMS1 complex","secondary_identifier":"SGD:S000004025","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR035C"}


id: YLR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein","secondary_identifier":"SGD:S000004026","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR036C"}


id: YLR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU23","product":"Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth","secondary_identifier":"SGD:S000004027","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR037C"}


id: YLR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02504":null,"YLR038C":null},"has_protein_features":false,"name":"COX12","ortholog_annotations":[{"gene_uniquename":"YLR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02504","reference_uniquename":"PMID:29761456"}],"product":"Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004028","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR038C"}


id: YLR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00143":null,"YLR039C":null},"has_protein_features":false,"name":"RIC1","ortholog_annotations":[{"gene_uniquename":"YLR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00143","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004029","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR039C"}


id: YLR040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AFB1","product":"MATalpha-specific a-factor blocker; contributes to mating efficiency under certain conditions; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W","secondary_identifier":"SGD:S000004030","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR040C"}


id: YLR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C","secondary_identifier":"SGD:S000004031","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR041W"}


id: YLR042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NFG1","product":"Cell wall protein of unknown function; localizes to the cytoplasm; deletion improves xylose fermentation in industrially engineered strains; YLR042C is not an essential gene","secondary_identifier":"SGD:S000004032","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR042C"}


id: YLR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04953":null,"YLR043C":null},"has_protein_features":false,"name":"TRX1","ortholog_annotations":[{"gene_uniquename":"YLR043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04953","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system that protects cells from oxidative and reductive stress; subunit of the LMA1 complex, with Pbi2p, that promotes vacuole inheritance; cofactor for Tsa1p; required for ER-Golgi transport; facilitates mitochondrial import of small Tims (Tim9p, Tim10p, Tim13p) by maintaining them in reduced form along with Trx2p; component of a signal transduction redox relay in a light sensing pathway; abundance increases under DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004033","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR043C"}


id: YLR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02734":null,"SJAG_03743":null,"SJAG_04842":null,"YLR044C":null},"has_protein_features":false,"name":"PDC1","ortholog_annotations":[{"gene_uniquename":"YLR044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02734","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03743","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04842","reference_uniquename":"PMID:29761456"}],"product":"Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004034","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR044C"}


id: YLR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02624":null,"SJAG_03540":null,"YLR045C":null},"has_protein_features":false,"name":"STU2","ortholog_annotations":[{"gene_uniquename":"YLR045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02624","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03540","reference_uniquename":"PMID:29761456"}],"product":"Microtubule polymerase of the XMAP215/Dis1 family; required for elongation of mitotic spindle during anaphase, as well as for spindle orientation and metaphase chromosome alignment; stabilizes or destabilizes kinetochore-microtubule attachment depending on kinetochore tension; interacts with spindle pole body component Spc72p; metazoan ch-TOG/XMAP215 family member","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004035","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR045C"}


id: YLR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00018":null,"SJAG_00587":null,"SJAG_00589":null,"SJAG_01095":null,"SJAG_02114":null,"SJAG_02132":null,"SJAG_02581":null,"SJAG_02943":null,"SJAG_02957":null,"YLR046C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00018","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00587","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00589","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01095","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02114","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02132","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02581","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02943","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02957","reference_uniquename":"PMID:29761456"}],"product":"Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YLR046C has a paralog, RTA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004036","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR046C"}


id: YLR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04743":null,"YLR047C":null},"has_protein_features":false,"name":"FRE8","ortholog_annotations":[{"gene_uniquename":"YLR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Protein with sequence similarity to iron/copper reductases; involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004037","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR047C"}


id: YLR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02184":null,"SJAG_02479":null,"SJAG_02803":null,"YLR048W":null},"has_protein_features":false,"name":"RPS0B","ortholog_annotations":[{"gene_uniquename":"YLR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02184","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02479","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02803","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004038","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR048W"}


id: YLR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MLO50","product":"Mitochondrial protein of unknown function","secondary_identifier":"SGD:S000004039","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR049C"}


id: YLR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_07010":null,"YLR050C":null},"has_protein_features":false,"name":"EMA19","ortholog_annotations":[{"gene_uniquename":"YLR050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07010","reference_uniquename":"PMID:29761456"}],"product":"Integral ER membrane protein involved in protein sorting; component of ER-SURF, a pathway involved in retrieving mitochondrial membrane protein precursors and rerouting them to the mitochondrial translocation system; promotes the proteolytic degradation of non-productive mitochondrial precursor proteins suggesting involvement in quality control during protein import; GFP-fusion protein localizes to the ER; member of a conserved family of ER proteins including human homolog TMEM97","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004040","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR050C"}


id: YLR051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04838":null,"YLR051C":null},"has_protein_features":false,"name":"FCF2","ortholog_annotations":[{"gene_uniquename":"YLR051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04838","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004041","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR051C"}


id: YLR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IES3","product":"Subunit of the INO80 chromatin remodeling complex","secondary_identifier":"SGD:S000004042","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR052W"}


id: YLR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000004043","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR053C"}


id: YLR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OSW2","product":"Protein of unknown function reputedly involved in spore wall assembly","secondary_identifier":"SGD:S000004044","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR054C"}


id: YLR055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02066":null,"YLR055C":null},"has_protein_features":false,"name":"SPT8","ortholog_annotations":[{"gene_uniquename":"YLR055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02066","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SAGA transcriptional regulatory complex; not present in SAGA-like complex SLIK/SALSA; required for SAGA-mediated inhibition at some promoters","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004045","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR055C"}


id: YLR056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00717":null,"SJAG_03509":null,"YLR056W":null},"has_protein_features":false,"name":"ERG3","ortholog_annotations":[{"gene_uniquename":"YLR056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00717","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03509","reference_uniquename":"PMID:29761456"}],"product":"C-5 sterol desaturase; glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of HRD ubiquitin ligase; mutation is functionally complemented by human SC5D","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004046","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR056W"}


id: YLR057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MNL2","product":"Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene","secondary_identifier":"SGD:S000004047","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR057W"}


id: YLR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01766":null,"YLR058C":null},"has_protein_features":false,"name":"SHM2","ortholog_annotations":[{"gene_uniquename":"YLR058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01766","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004048","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR058C"}


id: YLR059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00401":null,"YLR059C":null},"has_protein_features":false,"name":"REX2","ortholog_annotations":[{"gene_uniquename":"YLR059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00401","reference_uniquename":"PMID:29761456"}],"product":"3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004049","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR059C"}


id: YLR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02206":null,"YLR060W":null},"has_protein_features":false,"name":"FRS1","ortholog_annotations":[{"gene_uniquename":"YLR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02206","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004050","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR060W"}


id: YLR061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00220":null,"YLR061W":null},"has_protein_features":false,"name":"RPL22A","ortholog_annotations":[{"gene_uniquename":"YLR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00220","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L22A; required for translation of long 5' UTR of IME1 mRNA and meiotic entry; required for the oxidative stress response, pseudohyphal and invasive growth; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004051","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR061W"}


id: YLR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BUD28","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay","secondary_identifier":"SGD:S000004052","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR062C"}


id: YLR063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BMT6","product":"Methyltransferase required for m3U2843 methylation of the 25S rRNA; S-adenosylmethionine-dependent; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene","secondary_identifier":"SGD:S000004053","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR063W"}


id: YLR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01460":null,"YLR064W":null},"has_protein_features":false,"name":"PER33","ortholog_annotations":[{"gene_uniquename":"YLR064W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01460","reference_uniquename":"PMID:29761456"}],"product":"Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004054","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR064W"}


id: YLR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03315":null,"YLR065C":null},"has_protein_features":false,"name":"SND2","ortholog_annotations":[{"gene_uniquename":"YLR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03315","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Pho88p/Snd3p and Sec61p-translocon subunits; can compensate for loss of SRP; role in the late endosome-vacuole interface; putative role in secretory protein quality control","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004055","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR065C"}


id: YLR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03737":null,"YLR066W":null},"has_protein_features":false,"name":"SPC3","ortholog_annotations":[{"gene_uniquename":"YLR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03737","reference_uniquename":"PMID:29761456"}],"product":"Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; other members of the complex are Spc1p, Spc2p, and Sec11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004056","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR066W"}


id: YLR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01249":null,"YLR067C":null},"has_protein_features":false,"name":"PET309","ortholog_annotations":[{"gene_uniquename":"YLR067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01249","reference_uniquename":"PMID:29761456"}],"product":"Specific translational activator for the COX1 mRNA; binds to the COX1 mRNA; also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains 12 pentatricopeptide repeats (PPRs)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004057","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR067C"}


id: YLR068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01250":null,"YLR068W":null},"has_protein_features":false,"name":"FYV7","ortholog_annotations":[{"gene_uniquename":"YLR068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01250","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004058","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR068W"}


id: YLR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02353":null,"YLR069C":null},"has_protein_features":false,"name":"MEF1","ortholog_annotations":[{"gene_uniquename":"YLR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02353","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial elongation factor involved in translational elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004059","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR069C"}


id: YLR070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00237":null,"YLR070C":null},"has_protein_features":false,"name":"XYL2","ortholog_annotations":[{"gene_uniquename":"YLR070C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00237","reference_uniquename":"PMID:29761456"}],"product":"Xylitol dehydrogenase; converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004060","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR070C"}


id: YLR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03573":null,"YLR071C":null},"has_protein_features":false,"name":"RGR1","ortholog_annotations":[{"gene_uniquename":"YLR071C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03573","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004061","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR071C"}


id: YLR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01329":null,"YLR072W":null},"has_protein_features":false,"name":"LAM6","ortholog_annotations":[{"gene_uniquename":"YLR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01329","reference_uniquename":"PMID:29761456"}],"product":"Sterol transporter that transfers sterols between membranes; may regulate and coordinate formation of contact sites between organelles; localizes to ER-mitochondrial contact sites in a Tom70p- and Tom71p-dependent manner; mitochondrial localization requires GRAM domain; also localizes to ER-vacuole contact sites, in a Vac8p-dependent manner; has GRAM and StART-like (VASt) domains; one of six StART-like domain-containing proteins in yeast; conserved across eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004062","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR072W"}


id: YLR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RFU1","product":"Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes","secondary_identifier":"SGD:S000004063","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR073C"}


id: YLR074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01280":null,"YLR074C":null},"has_protein_features":false,"name":"BUD20","ortholog_annotations":[{"gene_uniquename":"YLR074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01280","reference_uniquename":"PMID:29761456"}],"product":"C2H2-type zinc finger protein required for ribosome assembly; shuttling factor which associates with pre-60S particles in the nucleus, accompanying them to the cytoplasm; cytoplasmic dissociation of Bud20p requires Drg1p; N-terminus harbors a nuclear localization signal (NLS) and a nuclear export signal (NES); cytoplasmic Bud20p is reimported by Kap123-dependent pathway; involved in bud-site selection; diploid mutants display a random budding pattern; similar to human ZNF593","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004064","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR074C"}


id: YLR075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04176":null,"YLR075W":null},"has_protein_features":false,"name":"RPL10","ortholog_annotations":[{"gene_uniquename":"YLR075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04176","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L10; homologous to mammalian ribosomal protein L10 and bacterial L16; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; protein abundance increases under DNA replication stress; mutations in human homolog implicated in T-cell acute lymphoblastic leukemia and also autism spectrum disorders (ASD); human RPL10 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004065","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR075W"}


id: YLR076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10","secondary_identifier":"SGD:S000004066","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR076C"}


id: YLR077W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FMP25","product":"Protein required for assembly of respiratory complex III; mitochondrial inner membrane protein; required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria","secondary_identifier":"SGD:S000004067","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR077W"}


id: YLR078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04513":null,"YLR078C":null},"has_protein_features":false,"name":"BOS1","ortholog_annotations":[{"gene_uniquename":"YLR078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04513","reference_uniquename":"PMID:29761456"}],"product":"v-SNARE (vesicle specific SNAP receptor); localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi; required for efficient nuclear fusion during mating","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004068","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR078C"}


id: YLR079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SIC1","product":"Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylated by Clb5/6-Cdk1 and Cln1/2-Cdk1 kinase which regulate timing of Sic1p degradation; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1","secondary_identifier":"SGD:S000004069","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR079W"}


id: YLR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02839":null,"YLR080W":null},"has_protein_features":false,"name":"EMP46","ortholog_annotations":[{"gene_uniquename":"YLR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02839","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane component of ER-derived COPII-coated vesicles; functions in ER to Golgi transport; EMP46 has a paralog, EMP47, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004070","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR080W"}


id: YLR081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YLR081W":null},"has_protein_features":false,"name":"GAL2","ortholog_annotations":[{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Galactose permease; required for utilization of galactose; also able to transport glucose","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004071","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR081W"}


id: YLR082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SRL2","product":"Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation","secondary_identifier":"SGD:S000004072","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR082C"}


id: YLR083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00299":null,"YLR083C":null},"has_protein_features":false,"name":"EMP70","ortholog_annotations":[{"gene_uniquename":"YLR083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00299","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in cellular adhesion and filamentous growth; also endosome-to-vacuole sorting; similar to Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; EMP70 has a paralog, TMN2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004073","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR083C"}


id: YLR084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01388":null,"YLR084C":null},"has_protein_features":false,"name":"RAX2","ortholog_annotations":[{"gene_uniquename":"YLR084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01388","reference_uniquename":"PMID:29761456"}],"product":"Protein required for the maintenance of bud site selection; localizes; localization to the bud neck and previous sites of cell division (bud scars; cytokinesis remnants (CRMs)) is interdependent with Rax2p; required with Rax1p to anchor both Nba1p and Nis1p to CRMs where a Cdc42p inhibitory zone is established preventing repolarization of cells at previous division sites; RAX2 mRNA stability is regulated by Mpt5p; predicted type I membrane-spanning protein; N-glycosylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004074","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR084C"}


id: YLR085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03694":null,"YLR085C":null},"has_protein_features":false,"name":"ARP6","ortholog_annotations":[{"gene_uniquename":"YLR085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03694","reference_uniquename":"PMID:29761456"}],"product":"Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004075","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR085C"}


id: YLR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00871":null,"YLR086W":null},"has_protein_features":false,"name":"SMC4","ortholog_annotations":[{"gene_uniquename":"YLR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00871","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004076","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR086W"}


id: YLR087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CSF1","product":"Protein required for fermentation at low temperature; plays a role in the maturation of secretory proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000004077","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR087C"}


id: YLR088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03292":null,"YLR088W":null},"has_protein_features":false,"name":"GAA1","ortholog_annotations":[{"gene_uniquename":"YLR088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03292","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the GPI:protein transamidase complex; removes the GPI-anchoring signal and attaches GPI (glycosylphosphatidylinositol) to proteins in the ER; human homolog GPAA1 can complement growth defects of yeast thermosensitive mutant at restrictive temperature","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004078","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR088W"}


id: YLR089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04145":null,"YLR089C":null},"has_protein_features":false,"name":"ALT1","ortholog_annotations":[{"gene_uniquename":"YLR089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04145","reference_uniquename":"PMID:29761456"}],"product":"Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthesis and catabolism; TOR1-independent role in determining chronological lifespan; expression is induced in the presence of alanine; repression is mediated by Nrg1p; ALT1 has a paralog, ALT2, that arose from the whole genome duplication; Alt2p is catalytically inactive","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004079","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR089C"}


id: YLR090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03135":null,"YLR090W":null},"has_protein_features":false,"name":"XDJ1","ortholog_annotations":[{"gene_uniquename":"YLR090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03135","reference_uniquename":"PMID:29761456"}],"product":"Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004080","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR090W"}


id: YLR091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GEP5","product":"Protein of unknown function; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine; localizes to the matrix side of the inner mitochondrial membrane","secondary_identifier":"SGD:S000004081","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR091W"}


id: YLR092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02463":null,"YLR092W":null},"has_protein_features":false,"name":"SUL2","ortholog_annotations":[{"gene_uniquename":"YLR092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02463","reference_uniquename":"PMID:29761456"}],"product":"High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004082","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR092W"}


id: YLR093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NYV1","product":"v-SNARE component of the vacuolar SNARE complex; involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane","secondary_identifier":"SGD:S000004083","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR093C"}


id: YLR094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GIS3","product":"Protein of unknown function","secondary_identifier":"SGD:S000004084","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR094C"}


id: YLR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IOC2","product":"Subunit of the Isw1b complex; exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing; contains a PHD finger motif; other complex members are Isw1p and Ioc4p","secondary_identifier":"SGD:S000004085","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR095C"}


id: YLR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02838":null,"YLR096W":null},"has_protein_features":false,"name":"KIN2","ortholog_annotations":[{"gene_uniquename":"YLR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02838","reference_uniquename":"PMID:29761456"}],"product":"S/T protein kinase; regulates polarized exocytosis and the Ire1p-mediated UPR; regulates HAC1 mRNA translocation, splicing and translation with KIN1 during ER stress; direct phosphorylation of Sec9p (S190) is enhanced by prior substrate priming (S192); localizes to the cytoplasmic face of the PM and sites of polarized growth; may regulate septin and cell wall organization; activation loop phosphorylation (T281) required for full kinase activity; orthologous to MARK/PAR-1, AMPK family members","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004086","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR096W"}


id: YLR097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03651":null,"YLR097C":null},"has_protein_features":false,"name":"HRT3","ortholog_annotations":[{"gene_uniquename":"YLR097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03651","reference_uniquename":"PMID:29761456"}],"product":"Putative SCF-ubiquitin ligase F-box protein; based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004087","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR097C"}


id: YLR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05337":null,"YLR098C":null},"has_protein_features":false,"name":"CHA4","ortholog_annotations":[{"gene_uniquename":"YLR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05337","reference_uniquename":"PMID:29761456"}],"product":"DNA binding transcriptional activator; mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004088","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR098C"}


id: YLR099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ICT1","product":"Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication; human ABHD5 can complement ict1 null mutant","secondary_identifier":"SGD:S000004089","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR099C"}


id: YLR099W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02361":null,"YLR099W-A":null},"has_protein_features":false,"name":"MIM2","ortholog_annotations":[{"gene_uniquename":"YLR099W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02361","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for outer membrane protein import; involved in import of the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and Fzo1p; component of a large protein complex in the outer membrane that includes Mim1p and functions as cation-selective channel for translocation of positively charged precursor segments; not essential in W303 strain background","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007618","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR099W-A"}


id: YLR100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03235":null,"YLR100W":null},"has_protein_features":false,"name":"ERG27","ortholog_annotations":[{"gene_uniquename":"YLR100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03235","reference_uniquename":"PMID:29761456"}],"product":"3-keto sterol reductase; catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs; mutation is functionally complemented by human HSD17B7","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004090","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR100W"}


id: YLR101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W","secondary_identifier":"SGD:S000004091","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR101C"}


id: YLR102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"APC9","product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition","secondary_identifier":"SGD:S000004092","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR102C"}


id: YLR103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00327":null,"YLR103C":null},"has_protein_features":false,"name":"CDC45","ortholog_annotations":[{"gene_uniquename":"YLR103C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00327","reference_uniquename":"PMID:29761456"}],"product":"DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004093","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR103C"}


id: YLR104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LCL2","product":"Putative protein of unknown function; mutant is deficient in cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD); SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole","secondary_identifier":"SGD:S000004094","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR104W"}


id: YLR105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03328":null,"YLR105C":null},"has_protein_features":false,"name":"SEN2","ortholog_annotations":[{"gene_uniquename":"YLR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03328","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease;","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004095","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR105C"}


id: YLR106C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03496":null,"YLR106C":null},"has_protein_features":false,"name":"REA1","ortholog_annotations":[{"gene_uniquename":"YLR106C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03496","reference_uniquename":"PMID:29761456"}],"product":"Huge dynein-related AAA-type ATPase (midasin); forms extended pre-60S particle with the Rix1 complex; involved with interaction partners Rsa4p and Ytm1p, in the ATP-dependent remodeling of the pre-60S particle at successive maturation steps during ribosomal biogenesis; involved in the removal of biogenesis factors including GTPase Nog2p prior to nuclear export; contains a hexameric AAA-motor head domain and a long flexible tail with a MIDAS (metal ion-dependent adhesion site) domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004096","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR106C"}


id: YLR107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00081":null,"YLR107W":null},"has_protein_features":false,"name":"REX3","ortholog_annotations":[{"gene_uniquename":"YLR107W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00081","reference_uniquename":"PMID:29761456"}],"product":"RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004097","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR107W"}


id: YLR108C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004098","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR108C"}


id: YLR109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03166":null,"YLR109W":null},"has_protein_features":false,"name":"AHP1","ortholog_annotations":[{"gene_uniquename":"YLR109W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03166","reference_uniquename":"PMID:29761456"}],"product":"Thiol-specific peroxiredoxin; reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004099","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR109W"}


id: YLR110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CCW12","product":"Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004100","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR110C"}


id: YLR111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000004101","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR111W"}


id: YLR112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000004102","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR112W"}


id: YLR113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02592":null,"YLR113W":null},"has_protein_features":false,"name":"HOG1","ortholog_annotations":[{"gene_uniquename":"YLR113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02592","reference_uniquename":"PMID:29761456"}],"product":"Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004103","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR113W"}


id: YLR114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02443":null,"YLR114C":null},"has_protein_features":false,"name":"AVL9","ortholog_annotations":[{"gene_uniquename":"YLR114C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02443","reference_uniquename":"PMID:29761456"}],"product":"Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004104","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR114C"}


id: YLR115W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03226":null,"YLR115W":null},"has_protein_features":false,"name":"CFT2","ortholog_annotations":[{"gene_uniquename":"YLR115W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03226","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004105","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR115W"}


id: YLR116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00249":null,"YLR116W":null},"has_protein_features":false,"name":"MSL5","ortholog_annotations":[{"gene_uniquename":"YLR116W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00249","reference_uniquename":"PMID:29761456"}],"product":"Component of commitment complex; which defines first step in splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004106","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR116W"}


id: YLR117C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00911":null,"YLR117C":null},"has_protein_features":false,"name":"CLF1","ortholog_annotations":[{"gene_uniquename":"YLR117C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00911","reference_uniquename":"PMID:29761456"}],"product":"Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004107","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR117C"}


id: YLR118C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02268":null,"YLR118C":null},"has_protein_features":false,"name":"TML25","ortholog_annotations":[{"gene_uniquename":"YLR118C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02268","reference_uniquename":"PMID:29761456"}],"product":"Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004108","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR118C"}


id: YLR119W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SRN2","product":"Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus","secondary_identifier":"SGD:S000004109","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR119W"}


id: YLR120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00109":null,"SJAG_00254":null,"SJAG_00784":null,"SJAG_02260":null,"YLR120C":null},"has_protein_features":false,"name":"YPS1","ortholog_annotations":[{"gene_uniquename":"YLR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00109","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00254","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00784","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02260","reference_uniquename":"PMID:29761456"}],"product":"Aspartic protease; hyperglycosylated member of the yapsin family of proteases, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; involved in nutrient limitation-induced cleavage of the extracellular inhibitory domain of signaling mucin Msb2p, resulting in activation of the filamentous growth MAPK pathway; involved with other yapsins in the cell wall integrity response; role in KEX2-independent processing of the alpha factor precursor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004110","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR120C"}


id: YLR120W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR121C","secondary_identifier":"SGD:S000028674","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR120W-A"}


id: YLR121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00109":null,"SJAG_00254":null,"SJAG_00784":null,"SJAG_02260":null,"YLR121C":null},"has_protein_features":false,"name":"YPS3","ortholog_annotations":[{"gene_uniquename":"YLR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00109","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00254","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00784","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02260","reference_uniquename":"PMID:29761456"}],"product":"Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004111","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR121C"}


id: YLR122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; partially overlaps dubious ORF YLR123C","secondary_identifier":"SGD:S000004112","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR122C"}


id: YLR123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif","secondary_identifier":"SGD:S000004113","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR123C"}


id: YLR124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004114","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR124W"}


id: YLR125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene","secondary_identifier":"SGD:S000004115","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR125W"}


id: YLR126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00811":null,"YLR126C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR126C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00811","reference_uniquename":"PMID:29761456"}],"product":"Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004116","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR126C"}


id: YLR127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03575":null,"YLR127C":null},"has_protein_features":false,"name":"APC2","ortholog_annotations":[{"gene_uniquename":"YLR127C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03575","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004117","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR127C"}


id: YLR128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00033":null,"YLR128W":null},"has_protein_features":false,"name":"DCN1","ortholog_annotations":[{"gene_uniquename":"YLR128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00033","reference_uniquename":"PMID:29761456"}],"product":"Scaffold-type E3 ligase; required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004118","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR128W"}


id: YLR129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02300":null,"YLR129W":null},"has_protein_features":false,"name":"DIP2","ortholog_annotations":[{"gene_uniquename":"YLR129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02300","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004119","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR129W"}


id: YLR130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04185":null,"YLR130C":null},"has_protein_features":false,"name":"ZRT2","ortholog_annotations":[{"gene_uniquename":"YLR130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04185","reference_uniquename":"PMID:29761456"}],"product":"Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004120","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR130C"}


id: YLR131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02252":null,"YLR131C":null},"has_protein_features":false,"name":"ACE2","ortholog_annotations":[{"gene_uniquename":"YLR131C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02252","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor required for septum destruction after cytokinesis; part of the RAM network that regulates polarity and morphogenesis; NES phosphorylation by RAM network kinase Cbk1p blocks nuclear exit in mother cells during the M/G1 transition, causing asymmetric localization to daughter cell nuclei, and increased Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; Spt16p is required for nuclear exclusion during G1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004121","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR131C"}


id: YLR132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01798":null,"YLR132C":null},"has_protein_features":false,"name":"USB1","ortholog_annotations":[{"gene_uniquename":"YLR132C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01798","reference_uniquename":"PMID:29761456"}],"product":"Putative poly(U)-specific 3'-to-5' RNA exonuclease; involved in 3'-end processing of U6 snRNA removing uridines and generating a terminal 2&#8242;,3&#8242; cyclic phosphate; essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants; homolog of S.pombe gene, mpn1 and human gene, hUSB1; mutations in hUSB1 are associated with a rare genodermatosis, poikiloderma with neutropenia (OMIM 604173)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004122","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR132C"}


id: YLR133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01918":null,"YLR133W":null},"has_protein_features":false,"name":"CKI1","ortholog_annotations":[{"gene_uniquename":"YLR133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01918","reference_uniquename":"PMID:29761456"}],"product":"Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004123","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR133W"}


id: YLR134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02734":null,"SJAG_03743":null,"SJAG_04842":null,"YLR134W":null},"has_protein_features":false,"name":"PDC5","ortholog_annotations":[{"gene_uniquename":"YLR134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02734","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03743","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04842","reference_uniquename":"PMID:29761456"}],"product":"Minor isoform of pyruvate decarboxylase; key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004124","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR134W"}


id: YLR135W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05180":null,"YLR135W":null},"has_protein_features":false,"name":"SLX4","ortholog_annotations":[{"gene_uniquename":"YLR135W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05180","reference_uniquename":"PMID:29761456"}],"product":"Endonuclease involved in processing DNA; acts during recombination, repair; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); cleaves branched structures in complex with Slx1p; involved in interstrand cross-link repair, Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress; FANCP-related factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004125","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR135W"}


id: YLR136C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04682":null,"YLR136C":null},"has_protein_features":false,"name":"TIS11","ortholog_annotations":[{"gene_uniquename":"YLR136C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04682","reference_uniquename":"PMID:29761456"}],"product":"mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; TIS11 has a paralog, CTH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004126","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR136C"}


id: YLR137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RKM5","product":"Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species","secondary_identifier":"SGD:S000004127","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR137W"}


id: YLR138W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01541":null,"YLR138W":null},"has_protein_features":false,"name":"NHA1","ortholog_annotations":[{"gene_uniquename":"YLR138W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01541","reference_uniquename":"PMID:29761456"}],"product":"Na+/H+ antiporter; involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004128","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR138W"}


id: YLR139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04929":null,"YLR139C":null},"has_protein_features":false,"name":"SLS1","ortholog_annotations":[{"gene_uniquename":"YLR139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04929","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial membrane protein; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004129","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR139C"}


id: YLR140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I","secondary_identifier":"SGD:S000004130","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR140W"}


id: YLR141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04766":null,"YLR141W":null},"has_protein_features":false,"name":"RRN5","ortholog_annotations":[{"gene_uniquename":"YLR141W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04766","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004131","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR141W"}


id: YLR142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01903":null,"YLR142W":null},"has_protein_features":false,"name":"PUT1","ortholog_annotations":[{"gene_uniquename":"YLR142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01903","reference_uniquename":"PMID:29761456"}],"product":"Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004132","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR142W"}


id: YLR143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04544":null,"YLR143W":null},"has_protein_features":false,"name":"DPH6","ortholog_annotations":[{"gene_uniquename":"YLR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04544","reference_uniquename":"PMID:29761456"}],"product":"Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004133","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR143W"}


id: YLR144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00667":null,"SJAG_01017":null,"YLR144C":null},"has_protein_features":false,"name":"ACF2","ortholog_annotations":[{"gene_uniquename":"YLR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00667","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01017","reference_uniquename":"PMID:29761456"}],"product":"Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004134","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR144C"}


id: YLR145W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03952":null,"YLR145W":null},"has_protein_features":false,"name":"RMP1","ortholog_annotations":[{"gene_uniquename":"YLR145W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03952","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNase MRP; RNase MRP processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004135","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR145W"}


id: YLR146C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04481":null,"YLR146C":null},"has_protein_features":false,"name":"SPE4","ortholog_annotations":[{"gene_uniquename":"YLR146C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04481","reference_uniquename":"PMID:29761456"}],"product":"Spermine synthase; required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004136","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR146C"}


id: YLR146W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function","secondary_identifier":"SGD:S000113566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR146W-A"}


id: YLR147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01301":null,"YLR147C":null},"has_protein_features":false,"name":"SMD3","ortholog_annotations":[{"gene_uniquename":"YLR147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01301","reference_uniquename":"PMID:29761456"}],"product":"Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004137","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR147C"}


id: YLR148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03005":null,"YLR148W":null},"has_protein_features":false,"name":"PEP3","ortholog_annotations":[{"gene_uniquename":"YLR148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03005","reference_uniquename":"PMID:29761456"}],"product":"Component of CORVET membrane tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004138","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR148W"}


id: YLR149C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04170":null,"YLR149C":null},"has_protein_features":false,"name":"GID11","ortholog_annotations":[{"gene_uniquename":"YLR149C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04170","reference_uniquename":"PMID:29761456"}],"product":"Substrate receptor of the glucose-induced degradation-deficient (GID) complex that targets gluconeogenic enzymes for proteasomal degradation upon switch from ethanol to glucose as a carbon source; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004139","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR149C"}


id: YLR149C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR149C-A"}


id: YLR150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04383":null,"YLR150W":null},"has_protein_features":false,"name":"STM1","ortholog_annotations":[{"gene_uniquename":"YLR150W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04383","reference_uniquename":"PMID:29761456"}],"product":"Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004140","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR150W"}


id: YLR151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02247":null,"YLR151C":null},"has_protein_features":false,"name":"PCD1","ortholog_annotations":[{"gene_uniquename":"YLR151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02247","reference_uniquename":"PMID:29761456"}],"product":"8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004141","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR151C"}


id: YLR152C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YLR152C is not an essential gene","secondary_identifier":"SGD:S000004142","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR152C"}


id: YLR153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02741":null,"YLR153C":null},"has_protein_features":false,"name":"ACS2","ortholog_annotations":[{"gene_uniquename":"YLR153C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02741","reference_uniquename":"PMID:29761456"}],"product":"Acetyl-coA synthetase isoform; along with Acs1p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004143","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR153C"}


id: YLR154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01884":null,"YLR154C":null},"has_protein_features":false,"name":"RNH203","ortholog_annotations":[{"gene_uniquename":"YLR154C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01884","reference_uniquename":"PMID:29761456"}],"product":"Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS3 that causes Aicardi-Goutieres syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004144","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154C"}


id: YLR154C-G
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-2","secondary_identifier":"SGD:S000028561","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154C-G"}


id: YLR154C-H
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-2; YLR154C-H has a paralog, YLR157C-C, that arose from a segmental duplication","secondary_identifier":"SGD:S000028562","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154C-H"}


id: YLR154W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 25S rRNA gene on the opposite strand","secondary_identifier":"SGD:S000028675","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154W-A"}


id: YLR154W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 25S rRNA gene on the opposite strand","secondary_identifier":"SGD:S000028563","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154W-B"}


id: YLR154W-C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TAR1","product":"Protein potentially involved in regulation of respiratory metabolism; located in the mitochondria; interacts genetically with RPO41 and physically with Coq5p; encoded within the 25S rRNA gene on the opposite strand","secondary_identifier":"SGD:S000028422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154W-C"}


id: YLR154W-E
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 35S rRNA gene on the opposite strand","secondary_identifier":"SGD:S000028676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154W-E"}


id: YLR154W-F
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 35S rRNA gene on the opposite strand","secondary_identifier":"SGD:S000028843","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154W-F"}


id: YLR155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ASP3-1","product":"Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; reference strain S288C has four copies of ASP3; ASP3-1 has a paralog, ASP3-3, that arose from a segmental duplication","secondary_identifier":"SGD:S000004145","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR155C"}


id: YLR156C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; partially overlaps RND5-3; YLR156C-A has a paralog, YLR159C-A, that arose from a segmental duplication","secondary_identifier":"SGD:S000028564","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR156C-A"}


id: YLR156W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; exhibits a two-hybrid interaction with Jsn1p in a large-scale analysis; YLR156W has a paralog, YLR159W, that arose from a segmental duplication","secondary_identifier":"SGD:S000004146","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR156W"}


id: YLR157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ASP3-2","product":"Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; reference strain S288C has four copies of ASP3; ASP3-2 has a paralog, ASP3-4, that arose from a segmental duplication","secondary_identifier":"SGD:S000004147","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR157C"}


id: YLR157C-C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-4; YLR157C-C has a paralog, YLR154C-H, that arose from a segmental duplication","secondary_identifier":"SGD:S000028565","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR157C-C"}


id: YLR157W-D
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; YLR157W-D has a paralog, YLR161W, that arose from a segmental duplication","secondary_identifier":"SGD:S000028677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR157W-D"}


id: YLR157W-E
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function identified by gene-trapping; microarray-based expression analysis, and genome-wide homology searching; partially overlaps a Ty1 element","secondary_identifier":"SGD:S000028678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR157W-E"}


id: YLR158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ASP3-3","product":"Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; reference strain S288C has four copies of ASP3; ASP3-3 has a paralog, ASP3-1, that arose from a segmental duplication","secondary_identifier":"SGD:S000004148","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR158C"}


id: YLR159C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; partially overlaps RND5-5; YLR159C-A has a paralog, YLR156C-A, that arose from a segmental duplication","secondary_identifier":"SGD:S000028566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR159C-A"}


id: YLR159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames in S288C encoded near the ribosomal DNA region of chromosome 12; YLR159W has a paralog, YLR156W, that arose from a segmental duplication","secondary_identifier":"SGD:S000004149","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR159W"}


id: YLR160C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ASP3-4","product":"Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; reference strain S288C has four copies of ASP3; ASP3-4 has a paralog, ASP3-2, that arose from a segmental duplication","secondary_identifier":"SGD:S000004150","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR160C"}


id: YLR161W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames in S288C encoded near the ribosomal DNA region of chromosome 12; YLR161W has a paralog, YLR157W-D, that arose from a segmental duplication","secondary_identifier":"SGD:S000004151","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR161W"}


id: YLR162W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; overexpression confers resistance to the antimicrobial peptide MiAMP1 and causes growth arrest, apoptosis, and increased sensitivity to cobalt chloride","secondary_identifier":"SGD:S000004152","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR162W"}


id: YLR162W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RRT15","product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; identified in a screen for mutants with decreased levels of rDNA transcription","secondary_identifier":"SGD:S000028567","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR162W-A"}


id: YLR163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02397":null,"YLR163C":null},"has_protein_features":false,"name":"MAS1","ortholog_annotations":[{"gene_uniquename":"YLR163C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02397","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004153","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR163C"}


id: YLR163W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000028844","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR163W-A"}


id: YLR164W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02398":null,"YLR164W":null},"has_protein_features":false,"name":"SHH4","ortholog_annotations":[{"gene_uniquename":"YLR164W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02398","reference_uniquename":"PMID:29761456"}],"product":"Putative alternate subunit of succinate dehydrogenase (SDH); mitochondrial inner membrane protein; genetic interaction with SDH4 suggests that Shh4p can function as a functional SDH subunit; a fraction copurifies with SDH subunit Sdh3p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner; Shh4p has greater similarity to human SDHD (subunit D of SDH, implicated in paraganglioma) than does its paralog Sdh4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004154","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR164W"}


id: YLR165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PUS5","product":"Pseudouridine synthase; catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability","secondary_identifier":"SGD:S000004155","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR165C"}


id: YLR166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04044":null,"YLR166C":null},"has_protein_features":false,"name":"SEC10","ortholog_annotations":[{"gene_uniquename":"YLR166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04044","reference_uniquename":"PMID:29761456"}],"product":"Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004156","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR166C"}


id: YLR167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01226":null,"SJAG_02253":null,"YLR167W":null},"has_protein_features":false,"name":"RPS31","ortholog_annotations":[{"gene_uniquename":"YLR167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01226","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02253","reference_uniquename":"PMID:29761456"}],"product":"Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004157","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR167W"}


id: YLR168C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00576":null,"YLR168C":null},"has_protein_features":false,"name":"UPS2","ortholog_annotations":[{"gene_uniquename":"YLR168C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00576","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial intermembrane space protein; involved in phospholipid metabolism; forms complex with Mdm35p that transfers phosphatidylserine from outer membrane to inner membrane for phosphatidylethanolamine synthesis; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI; UPS2 has a paralog, UPS3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004158","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR168C"}


id: YLR169W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004159","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR169W"}


id: YLR170C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00379":null,"YLR170C":null},"has_protein_features":false,"name":"APS1","ortholog_annotations":[{"gene_uniquename":"YLR170C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00379","reference_uniquename":"PMID:29761456"}],"product":"Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004160","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR170C"}


id: YLR171W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004161","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR171W"}


id: YLR172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02467":null,"YLR172C":null},"has_protein_features":false,"name":"DPH5","ortholog_annotations":[{"gene_uniquename":"YLR172C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02467","reference_uniquename":"PMID:29761456"}],"product":"Methyltransferase required for synthesis of diphthamide; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004162","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR172C"}


id: YLR173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TAG1","product":"Vacuolar membrane protein involved in termination of autophagy; regulates autophagy termination during persistent nitrogen starvation through Atg1p-mediated re-phosphorylation of Atg13p and PAS disassembly; type II membrane protein containing a hydrophobic transmembrane region, with N-terminal region oriented toward the cytosol and C-terminus inside the lumen; luminal domain is glycosylated; forms foci in the vacuole membrane during starvation","secondary_identifier":"SGD:S000004163","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR173W"}


id: YLR174W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04362":null,"YLR174W":null},"has_protein_features":false,"name":"IDP2","ortholog_annotations":[{"gene_uniquename":"YLR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04362","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication; mutation in human homolog IDH1 is associated with low-grade gliomas and secondary glioblastomas","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004164","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR174W"}


id: YLR175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04754":null,"YLR175W":null},"has_protein_features":false,"name":"CBF5","ortholog_annotations":[{"gene_uniquename":"YLR175W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04754","reference_uniquename":"PMID:29761456"}],"product":"Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs; acts on large and small rRNAs, on snRNA U2, and on some mRNAs; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita; small nucleolar ribonucleoprotein particles are also known as snoRNPs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004165","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR175W"}


id: YLR176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04839":null,"YLR176C":null},"has_protein_features":false,"name":"RFX1","ortholog_annotations":[{"gene_uniquename":"YLR176C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04839","reference_uniquename":"PMID:29761456"}],"product":"Major transcriptional repressor of DNA-damage-regulated genes; recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004166","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR176C"}


id: YLR177W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04686":null,"YLR177W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04686","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004167","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR177W"}


id: YLR178C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TFS1","product":"Inhibitor of carboxypeptidase Y (Prc1p), and Ras GAP (Ira2p); phosphatidylethanolamine-binding protein (PEBP) family member and ortholog of hPEBP1/RKIP, a natural metastasis suppressor; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004168","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR178C"}


id: YLR179C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus","secondary_identifier":"SGD:S000004169","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR179C"}


id: YLR180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03659":null,"YLR180W":null},"has_protein_features":false,"name":"SAM1","ortholog_annotations":[{"gene_uniquename":"YLR180W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03659","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004170","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR180W"}


id: YLR181C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04047":null,"YLR181C":null},"has_protein_features":false,"name":"VTA1","ortholog_annotations":[{"gene_uniquename":"YLR181C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04047","reference_uniquename":"PMID:29761456"}],"product":"Multivesicular body (MVB) protein; involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004171","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR181C"}


id: YLR182W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02810":null,"YLR182W":null},"has_protein_features":false,"name":"SWI6","ortholog_annotations":[{"gene_uniquename":"YLR182W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02810","reference_uniquename":"PMID:29761456"}],"product":"Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004172","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR182W"}


id: YLR183C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04512":null,"YLR183C":null},"has_protein_features":false,"name":"TOS4","ortholog_annotations":[{"gene_uniquename":"YLR183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04512","reference_uniquename":"PMID:29761456"}],"product":"Putative transcription factor, contains Forkhead Associated domain; binds chromatin; involved in expression homeostasis, buffering of mRNA synthesis rate against gene dosage changes during S phase; target of SBF transcription factor; expression is periodic and peaks in G1; involved in DNA replication checkpoint response; interacts with Rpd3 and Set3 histone deacetylase complexes; APCC(Cdh1) substrate; relative distribution to nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004173","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR183C"}


id: YLR184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004174","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR184W"}


id: YLR185W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01194":null,"SJAG_03326":null,"YLR185W":null},"has_protein_features":false,"name":"RPL37A","ortholog_annotations":[{"gene_uniquename":"YLR185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01194","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03326","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L37A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004175","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR185W"}


id: YLR186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02024":null,"YLR186W":null},"has_protein_features":false,"name":"EMG1","ortholog_annotations":[{"gene_uniquename":"YLR186W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02024","reference_uniquename":"PMID:29761456"}],"product":"Methyltransferase for rRNA; methylates pseudouridine 18S rRNA residue 1191; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independent of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and equivalent yeast mutation affects Emg1p dimerization and localization but not methyltransferase activity; human EMG1 complements lethality of null and ts mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004176","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR186W"}


id: YLR187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SKG3","product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004177","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR187W"}


id: YLR188W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MDL1","product":"Mitochondrial inner membrane half-type ABC transporter; mediates export of peptides generated upon proteolysis of mitochondrial proteins; plays a role in the regulation of cellular resistance to oxidative stress","secondary_identifier":"SGD:S000004178","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR188W"}


id: YLR189C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATG26","product":"UDP-glucose:sterol glucosyltransferase; conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy","secondary_identifier":"SGD:S000004179","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR189C"}


id: YLR190W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MMR1","product":"Phosphorylated protein of the mitochondrial outer membrane; localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p","secondary_identifier":"SGD:S000004180","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR190W"}


id: YLR191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02693":null,"YLR191W":null},"has_protein_features":false,"name":"PEX13","ortholog_annotations":[{"gene_uniquename":"YLR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02693","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal importomer complex component; integral peroxisomal membrane protein required for docking and translocation of peroxisomal matrix proteins; interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p; forms a complex with Pex14p and Pex17p; human homolog PEX13 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004181","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR191W"}


id: YLR192C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04900":null,"YLR192C":null},"has_protein_features":false,"name":"HCR1","ortholog_annotations":[{"gene_uniquename":"YLR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04900","reference_uniquename":"PMID:29761456"}],"product":"eIF3j component of translation initiation factor 3 (eIF3); dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of eIF3; required for 20S pre-rRNA processing; required at post-transcriptional step for efficient retrotransposition; absence decreases Ty1 Gag:GFP protein levels; binds eIF3 subunits Rpg1p, Prt1p and 18S rRNA; eIF3 also involved in programmed stop codon read through; human homolog EIF3J can complement yeast hcr1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004182","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR192C"}


id: YLR193C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00230":null,"YLR193C":null},"has_protein_features":false,"name":"UPS1","ortholog_annotations":[{"gene_uniquename":"YLR193C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00230","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004183","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR193C"}


id: YLR194C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NCW2","product":"GPI-anchored protein involved in cell wall remodeling; involved in the assembly of the cell wall chitin-glucan structure and repair of damage caused by the antifungal agent polyhexamethylene biguanide; role in the cell wall integrity pathway; expression is upregulated in response to cell wall stress; transported to the cell surface after Pmt1p-Pmt2p-mediated O-mannosylation, colocalizing with bud scars","secondary_identifier":"SGD:S000004184","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR194C"}


id: YLR195C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00102":null,"YLR195C":null},"has_protein_features":false,"name":"NMT1","ortholog_annotations":[{"gene_uniquename":"YLR195C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00102","reference_uniquename":"PMID:29761456"}],"product":"N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004185","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR195C"}


id: YLR196W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01153":null,"YLR196W":null},"has_protein_features":false,"name":"PWP1","ortholog_annotations":[{"gene_uniquename":"YLR196W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01153","reference_uniquename":"PMID:29761456"}],"product":"Protein with WD-40 repeats involved in rRNA processing; associates with rDNA chromatin in H4-tail-dependent manner; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004186","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR196W"}


id: YLR197W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02377":null,"YLR197W":null},"has_protein_features":false,"name":"NOP56","ortholog_annotations":[{"gene_uniquename":"YLR197W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02377","reference_uniquename":"PMID:29761456"}],"product":"Essential evolutionarily-conserved nucleolar protein; component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004187","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR197W"}


id: YLR198C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W","secondary_identifier":"SGD:S000004188","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR198C"}


