# genes

id: YIR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Blocked reading frame; may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family","secondary_identifier":"SGD:S000001482","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR043C"}


id: YJL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03151":null,"YJL001W":null},"has_protein_features":false,"name":"PRE3","ortholog_annotations":[{"gene_uniquename":"YJL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03151","reference_uniquename":"PMID:29761456"}],"product":"Beta 1 subunit of the 20S proteasome; responsible for cleavage after acidic residues in peptides","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003538","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL001W"}


id: YJL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01006":null,"YJL002C":null},"has_protein_features":false,"name":"OST1","ortholog_annotations":[{"gene_uniquename":"YJL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01006","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003539","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL002C"}


id: YJL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03296":null,"YJL003W":null},"has_protein_features":false,"name":"COX16","ortholog_annotations":[{"gene_uniquename":"YJL003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03296","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein; required for assembly of cytochrome c oxidase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003540","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL003W"}


id: YJL004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SYS1","product":"Integral membrane protein of the Golgi; required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation","secondary_identifier":"SGD:S000003541","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL004C"}


id: YJL005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01254":null,"YJL005W":null},"has_protein_features":false,"name":"CYR1","ortholog_annotations":[{"gene_uniquename":"YJL005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01254","reference_uniquename":"PMID:29761456"}],"product":"Adenylate cyclase; required for cAMP production and cAMP-dependent protein kinase signaling; scaffold protein for Ras2-Ira interaction; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003542","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL005W"}


id: YJL006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02057":null,"YJL006C":null},"has_protein_features":false,"name":"CTK2","ortholog_annotations":[{"gene_uniquename":"YJL006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02057","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of C-terminal domain kinase I (CTDK-I); which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003543","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL006C"}


id: YJL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000003544","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL007C"}


id: YJL008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00447":null,"YJL008C":null},"has_protein_features":false,"name":"CCT8","ortholog_annotations":[{"gene_uniquename":"YJL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00447","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003545","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL008C"}


id: YJL009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex","secondary_identifier":"SGD:S000003546","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL009W"}


id: YJL010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02250":null,"YJL010C":null},"has_protein_features":false,"name":"NOP9","ortholog_annotations":[{"gene_uniquename":"YJL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02250","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of U3-containing 90S preribosome; involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003547","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL010C"}


id: YJL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03035":null,"YJL011C":null},"has_protein_features":false,"name":"RPC17","ortholog_annotations":[{"gene_uniquename":"YJL011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03035","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003548","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL011C"}


id: YJL012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01080":null,"YJL012C":null},"has_protein_features":false,"name":"VTC4","ortholog_annotations":[{"gene_uniquename":"YJL012C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01080","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003549","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL012C"}


id: YJL012C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YJL012C-A was originally annotated as an independent ORF but due to a sequence change was merged with an adjacent ORF into a single reading frame, designated YJL012C/VTC4","secondary_identifier":"SGD:S000007609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL012C-A"}


id: YJL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04699":null,"YJL013C":null},"has_protein_features":false,"name":"MAD3","ortholog_annotations":[{"gene_uniquename":"YJL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04699","reference_uniquename":"PMID:29761456"}],"product":"Subunit of spindle-assembly checkpoint complex; involved in delaying anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover; MAD3 has a paralog, BUB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003550","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL013C"}


id: YJL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03570":null,"YJL014W":null},"has_protein_features":false,"name":"CCT3","ortholog_annotations":[{"gene_uniquename":"YJL014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03570","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; capable of binding Q/N rich proteins and mediating their folding","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003551","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL014W"}


id: YJL015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W","secondary_identifier":"SGD:S000003552","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL015C"}


id: YJL016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TPH3","product":"Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; contains two adjacent PH-like domains; conserved in closely related Saccharomyces species","secondary_identifier":"SGD:S000003553","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL016W"}


id: YJL017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YJL017W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YJL016W","secondary_identifier":"SGD:S000003554","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL017W"}


id: YJL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YJL018W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YJL019W","secondary_identifier":"SGD:S000003555","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL018W"}


id: YJL019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05196":null,"YJL019W":null},"has_protein_features":false,"name":"MPS3","ortholog_annotations":[{"gene_uniquename":"YJL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05196","reference_uniquename":"PMID:29761456"}],"product":"Nuclear envelope protein; required for SPB insertion, SPB duplication, Kar5p localization near the SPB and nuclear fusion; interacts with Mps2p to tether half-bridge to core SPB; N-terminal acetylation by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; member of the SUN protein family (Sad1-UNC-84 homology)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003556","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL019W"}


id: YJL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02202":null,"YJL020C":null},"has_protein_features":false,"name":"BBC1","ortholog_annotations":[{"gene_uniquename":"YJL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02202","reference_uniquename":"PMID:29761456"}],"product":"Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003557","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL020C"}


id: YJL020W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL020C/BBC1","secondary_identifier":"SGD:S000028659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL020W-A"}


id: YJL021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YJL021C was originally annotated as an independent ORF but due to a sequence change was merged with an adjacent ORF into a single reading frame, designated YJL020C/BBC1","secondary_identifier":"SGD:S000003558","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL021C"}


id: YJL022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130","secondary_identifier":"SGD:S000003559","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL022W"}


id: YJL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PET130","product":"Protein of unknown function; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; localizes to the matrix side of the inner mitochondrial membrane","secondary_identifier":"SGD:S000003560","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL023C"}


id: YJL024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03726":null,"YJL024C":null},"has_protein_features":false,"name":"APS3","ortholog_annotations":[{"gene_uniquename":"YJL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03726","reference_uniquename":"PMID:29761456"}],"product":"Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003561","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL024C"}


id: YJL025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02813":null,"YJL025W":null},"has_protein_features":false,"name":"RRN7","ortholog_annotations":[{"gene_uniquename":"YJL025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02813","reference_uniquename":"PMID:29761456"}],"product":"Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003562","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL025W"}


id: YJL026C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL026W/RNR2","secondary_identifier":"SGD:S000028660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL026C-A"}


id: YJL026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00885":null,"YJL026W":null},"has_protein_features":false,"name":"RNR2","ortholog_annotations":[{"gene_uniquename":"YJL026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00885","reference_uniquename":"PMID:29761456"}],"product":"Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; RNR2 has a paralog, RNR4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003563","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL026W"}


id: YJL027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000003564","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL027C"}


id: YJL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments","secondary_identifier":"SGD:S000003565","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL028W"}


id: YJL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04902":null,"YJL029C":null},"has_protein_features":false,"name":"VPS53","ortholog_annotations":[{"gene_uniquename":"YJL029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04902","reference_uniquename":"PMID:29761456"}],"product":"Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; required for vacuolar protein sorting; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p; human ortholog is implicated in progressive cerebello-cerebral atrophy type 2 (PCCA2)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL029C"}


id: YJL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01330":null,"YJL030W":null},"has_protein_features":false,"name":"MAD2","ortholog_annotations":[{"gene_uniquename":"YJL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01330","reference_uniquename":"PMID:29761456"}],"product":"Component of the spindle-assembly checkpoint complex; delays onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003567","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL030W"}


id: YJL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03810":null,"YJL031C":null},"has_protein_features":false,"name":"BET4","ortholog_annotations":[{"gene_uniquename":"YJL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03810","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003568","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL031C"}


id: YJL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase","secondary_identifier":"SGD:S000003569","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL032W"}


id: YJL033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02287":null,"YJL033W":null},"has_protein_features":false,"name":"HCA4","ortholog_annotations":[{"gene_uniquename":"YJL033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02287","reference_uniquename":"PMID:29761456"}],"product":"DEAD box RNA helicase; component of the SSU; interacts with Bfr2p and Enp2p; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003570","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL033W"}


id: YJL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00790":null,"YJL034W":null},"has_protein_features":false,"name":"KAR2","ortholog_annotations":[{"gene_uniquename":"YJL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00790","reference_uniquename":"PMID:29761456"}],"product":"ATPase involved in protein import into the ER; also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003571","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL034W"}


id: YJL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04189":null,"YJL035C":null},"has_protein_features":false,"name":"TAD2","ortholog_annotations":[{"gene_uniquename":"YJL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04189","reference_uniquename":"PMID:29761456"}],"product":"Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003572","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL035C"}


id: YJL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01135":null,"SJAG_01382":null,"YJL036W":null},"has_protein_features":false,"name":"SNX4","ortholog_annotations":[{"gene_uniquename":"YJL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01135","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01382","reference_uniquename":"PMID:29761456"}],"product":"Sorting nexin; involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003573","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL036W"}


id: YJL037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IRC18","product":"Protein involved in outer spore wall assembly; possible role in assembly of the dityrosine layer; similar to adjacent ORF, LOH1; irc18 loh1 double mutant exhibits reduced dityrosine fluorescence relative to single mutants; SWAT-GFP fusion protein localizes to the ER and vacuole, while mCherry fusion localizes to the vacuole; expression induced in respiratory-deficient cells and carbon-limited chemostat culture; null mutant displays increased levels of spontaneous Rad52p foci","secondary_identifier":"SGD:S000003574","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL037W"}


id: YJL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LOH1","product":"Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to adjacent ORF, IRC18/YJL037W, and the irc18 loh1 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants; SWAT-GFP and mCherry fusion proteins localize to the cytosol; proposed role in maintenance of genome integrity","secondary_identifier":"SGD:S000003575","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL038C"}


id: YJL039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03182":null,"YJL039C":null},"has_protein_features":false,"name":"NUP192","ortholog_annotations":[{"gene_uniquename":"YJL039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03182","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of inner ring of nuclear pore complex (NPC); plays a role in modulating transport through the NPC; homologous to human NUP205","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003576","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL039C"}


id: YJL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02274":null,"YJL041W":null},"has_protein_features":false,"name":"NSP1","ortholog_annotations":[{"gene_uniquename":"YJL041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02274","reference_uniquename":"PMID:29761456"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003577","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL041W"}


id: YJL042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MHP1","product":"Microtubule-associated protein involved in microtubule organization; involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins","secondary_identifier":"SGD:S000003578","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL042W"}


id: YJL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YJL043W is a non-essential gene","secondary_identifier":"SGD:S000003579","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL043W"}


id: YJL044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GYP6","product":"GTPase-activating protein (GAP) for yeast Rab family member Ypt6p; involved in vesicle mediated protein transport","secondary_identifier":"SGD:S000003580","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL044C"}


id: YJL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01671":null,"YJL045W":null},"has_protein_features":false,"name":"SDH9","ortholog_annotations":[{"gene_uniquename":"YJL045W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01671","reference_uniquename":"PMID:29761456"}],"product":"Minor succinate dehydrogenase isozyme; participates in oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner; YJL045W has a paralog, SDH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003581","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL045W"}


id: YJL046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01164":null,"YJL046W":null},"has_protein_features":false,"name":"AIM22","ortholog_annotations":[{"gene_uniquename":"YJL046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01164","reference_uniquename":"PMID:29761456"}],"product":"Lipoate-protein ligase; octanoyl-CoA: protein transferase required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003582","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL046W"}


id: YJL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RTT101","product":"Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; role in anaphase progression; Rtt101p-Mms22p ligase associates with replisome complex during S phase via Ctf4p; required for recovery after DSB repair; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p","secondary_identifier":"SGD:S000003583","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL047C"}


id: YJL047C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028804","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL047C-A"}


id: YJL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"UBX6","product":"UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003584","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL048C"}


id: YJL049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05207":null,"YJL049W":null},"has_protein_features":false,"name":"CHM7","ortholog_annotations":[{"gene_uniquename":"YJL049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05207","reference_uniquename":"PMID:29761456"}],"product":"Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum presumably as part of an ESCRT-III like complex; null mutant has growth defect at 37 C in an apq12 deletion background; non-essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003585","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL049W"}


id: YJL050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_16455":null,"YJL050W":null},"has_protein_features":false,"name":"MTR4","ortholog_annotations":[{"gene_uniquename":"YJL050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16455","reference_uniquename":"PMID:29761456"}],"product":"RNA duplex-sensing translocase; ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003586","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL050W"}


id: YJL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IRC8","product":"Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc","secondary_identifier":"SGD:S000003587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL051W"}


id: YJL052C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified based on comparison to related yeast species; mCherry fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000007610","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL052C-A"}


id: YJL052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00027":null,"SJAG_02135":null,"SJAG_02945":null,"SJAG_03828":null,"SJAG_03903":null,"SJAG_06621":null,"SJAG_06622":null,"YJL052W":null},"has_protein_features":false,"name":"TDH1","ortholog_annotations":[{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00027","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02135","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02945","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03828","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03903","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06621","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06622","reference_uniquename":"PMID:29761456"}],"product":"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bateria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003588","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL052W"}


id: YJL053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00632":null,"YJL053W":null},"has_protein_features":false,"name":"PEP8","ortholog_annotations":[{"gene_uniquename":"YJL053W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00632","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003589","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL053W"}


id: YJL054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00404":null,"YJL054W":null},"has_protein_features":false,"name":"TIM54","ortholog_annotations":[{"gene_uniquename":"YJL054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00404","reference_uniquename":"PMID:29761456"}],"product":"Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003590","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL054W"}


id: YJL055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LOG1","product":"Putative protein of unknown function; functions together with HAM1 to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA, without affecting uptake or incorporation of uracil into RNA; proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA","secondary_identifier":"SGD:S000003591","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL055W"}


id: YJL056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ZAP1","product":"Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains","secondary_identifier":"SGD:S000003592","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL056C"}


id: YJL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IKS1","product":"Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p","secondary_identifier":"SGD:S000003593","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL057C"}


id: YJL058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01020":null,"SJAG_04987":null,"YJL058C":null},"has_protein_features":false,"name":"BIT61","ortholog_annotations":[{"gene_uniquename":"YJL058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01020","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04987","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003594","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL058C"}


id: YJL059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02716":null,"YJL059W":null},"has_protein_features":false,"name":"YHC3","ortholog_annotations":[{"gene_uniquename":"YJL059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02716","reference_uniquename":"PMID:29761456"}],"product":"Protein required for the ATP-dependent transport of arginine; vacuolar membrane protein; involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; human homolog CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003595","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL059W"}


id: YJL060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04988":null,"YJL060W":null},"has_protein_features":false,"name":"BNA3","ortholog_annotations":[{"gene_uniquename":"YJL060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04988","reference_uniquename":"PMID:29761456"}],"product":"Kynurenine aminotransferase; catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003596","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL060W"}


id: YJL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01065":null,"YJL061W":null},"has_protein_features":false,"name":"NUP82","ortholog_annotations":[{"gene_uniquename":"YJL061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01065","reference_uniquename":"PMID:29761456"}],"product":"Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p); relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003597","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL061W"}


id: YJL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02523":null,"YJL062W":null},"has_protein_features":false,"name":"LAS21","ortholog_annotations":[{"gene_uniquename":"YJL062W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02523","reference_uniquename":"PMID:29761456"}],"product":"Mannose-ethanolamine phosphotransferase; involved in biosynthesis of the glycosylphosphatidylinositol (GPI) core structure, catalyzing the addition of a side chain ethanolamine phosphate to the alpha1,6-linked second mannose residue of the GPI lipid precursor;  integral component of endoplasmic reticulum membrane; mutations affect cell wall integrity; homolog of human PIGG","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003598","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL062W"}


id: YJL062W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04348":null,"YJL062W-A":null},"has_protein_features":false,"name":"COA3","ortholog_annotations":[{"gene_uniquename":"YJL062W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04348","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for cytochrome c oxidase assembly; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; located in the mitochondrial inner membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007611","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL062W-A"}


id: YJL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01591":null,"YJL063C":null},"has_protein_features":false,"name":"MRPL8","ortholog_annotations":[{"gene_uniquename":"YJL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01591","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003599","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL063C"}


id: YJL064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1","secondary_identifier":"SGD:S000003600","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL064W"}


id: YJL065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DLS1","product":"Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003601","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL065C"}


id: YJL066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MPM1","product":"Mitochondrial intermembrane space protein of unknown function","secondary_identifier":"SGD:S000003602","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL066C"}


id: YJL067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003603","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL067W"}


id: YJL068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Esterase that can function as an S-formylglutathione hydrolase; non-essential intracellular esterase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D","secondary_identifier":"SGD:S000003604","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL068C"}


id: YJL069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00538":null,"YJL069C":null},"has_protein_features":false,"name":"UTP18","ortholog_annotations":[{"gene_uniquename":"YJL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00538","reference_uniquename":"PMID:29761456"}],"product":"Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; contains WD40 repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003605","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL069C"}


id: YJL070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003606","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL070C"}


id: YJL071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00695":null,"YJL071W":null},"has_protein_features":false,"name":"ARG2","ortholog_annotations":[{"gene_uniquename":"YJL071W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00695","reference_uniquename":"PMID:29761456"}],"product":"Acetylglutamate synthase (glutamate N-acetyltransferase); mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003607","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL071W"}


id: YJL072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00696":null,"YJL072C":null},"has_protein_features":false,"name":"PSF2","ortholog_annotations":[{"gene_uniquename":"YJL072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00696","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL072C"}


id: YJL073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"JEM1","product":"DnaJ-like chaperone required for nuclear membrane fusion during mating; localizes to the ER membrane; exhibits genetic interactions with KAR2","secondary_identifier":"SGD:S000003609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL073W"}


id: YJL074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05019":null,"YJL074C":null},"has_protein_features":false,"name":"SMC3","ortholog_annotations":[{"gene_uniquename":"YJL074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05019","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the multiprotein cohesin complex; required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003610","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL074C"}


id: YJL075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"APQ13","product":"Putative protein of unknown function; not conserved in closely related Saccharomyces species; 85% of ORF overlaps verified gene NET1, but does not share all phenotypes; null mutant is slow-growing, sensitive to heat, sorbate, and other various chemicals","secondary_identifier":"SGD:S000003611","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL075C"}


id: YJL076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00883":null,"YJL076W":null},"has_protein_features":false,"name":"NET1","ortholog_annotations":[{"gene_uniquename":"YJL076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00883","reference_uniquename":"PMID:29761456"}],"product":"Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003612","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL076W"}


id: YJL077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ICS3","product":"Protein with a role in copper homeostasis; possible role in vacuolar sorting and processing of secretory proteins; null mutants are hypersensitive to sortin2","secondary_identifier":"SGD:S000003613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL077C"}


id: YJL077W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data; completely overlaps the verified gene YJL077C/ICS3","secondary_identifier":"SGD:S000028661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL077W-A"}


id: YJL077W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL077W-B"}


id: YJL078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PRY3","product":"GPI-anchored cell wall protein involved in export of sterols; redundant role with PRY1 and PRY2 in the export of free fatty acids; role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins)","secondary_identifier":"SGD:S000003614","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL078C"}


id: YJL079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PRY1","product":"Lipid binding protein; binds to both free fatty acids with preference for saturated long-chain fatty acids and to sterols; contains two independent lipid-binding sites; involved in the export of free fatty acids and acetylated sterols; export functions are redundant with PRY2, and PRY3; important for survival of cells that accumulate free fatty acids; involved in detoxification  of hydrophobic compounds; secreted glycoprotein and member of the CAP/SCP protein superfamily","secondary_identifier":"SGD:S000003615","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL079C"}


id: YJL080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03696":null,"YJL080C":null},"has_protein_features":false,"name":"SCP160","ortholog_annotations":[{"gene_uniquename":"YJL080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03696","reference_uniquename":"PMID:29761456"}],"product":"Essential RNA-binding G protein effector of mating response pathway; ligand-activated RNA-binding protein that delivers RNAs involved in polarization and perpetualizing mating signal to shmoo tip during pheromone signaling; Scp160p-mediated RNA trafficking essential for chemotropism and successful mating; mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003616","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL080C"}


id: YJL081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01016":null,"SJAG_03058":null,"SJAG_03579":null,"YJL081C":null},"has_protein_features":false,"name":"ARP4","ortholog_annotations":[{"gene_uniquename":"YJL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01016","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03058","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03579","reference_uniquename":"PMID:29761456"}],"product":"Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003617","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL081C"}


id: YJL082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00219":null,"SJAG_00270":null,"YJL082W":null},"has_protein_features":false,"name":"IML2","ortholog_annotations":[{"gene_uniquename":"YJL082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00219","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00270","reference_uniquename":"PMID:29761456"}],"product":"Protein required for clearance of inclusion bodies; localizes to the inclusion bodies formed under protein misfolding stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003618","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL082W"}


id: YJL083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00724":null,"YJL083W":null},"has_protein_features":false,"name":"TAX4","ortholog_annotations":[{"gene_uniquename":"YJL083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00724","reference_uniquename":"PMID:29761456"}],"product":"EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL083W"}


id: YJL084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00032":null,"SJAG_03643":null,"YJL084C":null},"has_protein_features":false,"name":"ALY2","ortholog_annotations":[{"gene_uniquename":"YJL084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00032","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03643","reference_uniquename":"PMID:29761456"}],"product":"Alpha arrestin, Ub-ligase adaptor for Rsp5p; controls nutrient limitation-mediated endosomal recycling of the Gap1p amino acid permease; PY motif-containing adaptor involved in substrate-induced, Rsp5p-mediated ubiquitination and endocytosis of select plasma membrane localized amino acid transporters, such as Dip5p and Put4p; phosphorylated by Npr1p and by the Pcl7p-Pho85p cyclin-CDK complex; interacts with AP-1 subunit Apl4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003620","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL084C"}


id: YJL085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04960":null,"YJL085W":null},"has_protein_features":false,"name":"EXO70","ortholog_annotations":[{"gene_uniquename":"YJL085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04960","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003621","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL085W"}


id: YJL086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1","secondary_identifier":"SGD:S000003622","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL086C"}


id: YJL087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00956":null,"YJL087C":null},"has_protein_features":false,"name":"TRL1","ortholog_annotations":[{"gene_uniquename":"YJL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00956","reference_uniquename":"PMID:29761456"}],"product":"tRNA ligase; required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; involved in turnover of tRNA introns; localized at the inner nuclear envelope and cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003623","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL087C"}


id: YJL088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00635":null,"YJL088W":null},"has_protein_features":false,"name":"ARG3","ortholog_annotations":[{"gene_uniquename":"YJL088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00635","reference_uniquename":"PMID:29761456"}],"product":"Ornithine carbamoyltransferase; also known as carbamoylphosphate:L-ornithine carbamoyltransferase; catalyzes the biosynthesis of the arginine precursor citrulline","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003624","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL088W"}


id: YJL089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SIP4","product":"C6 zinc cluster transcriptional activator; binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus","secondary_identifier":"SGD:S000003625","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL089W"}


id: YJL090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02098":null,"YJL090C":null},"has_protein_features":false,"name":"DPB11","ortholog_annotations":[{"gene_uniquename":"YJL090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02098","reference_uniquename":"PMID:29761456"}],"product":"DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; along with Rfa1p, binds to ultrafine anaphase bridges in mitotic cells and prevents accumulation of chromatin bridges by stimulating the Mec1p kinase and suppressing homologous recombination; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL090C"}


id: YJL091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00068":null,"YJL091C":null},"has_protein_features":false,"name":"GWT1","ortholog_annotations":[{"gene_uniquename":"YJL091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00068","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in the inositol acylation of GlcN-PI; the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) forms glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL091C"}


id: YJL092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01221":null,"YJL092W":null},"has_protein_features":false,"name":"SRS2","ortholog_annotations":[{"gene_uniquename":"YJL092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01221","reference_uniquename":"PMID:29761456"}],"product":"DNA helicase and DNA-dependent ATPase; role in DNA repair and checkpoint recovery, in the proper timing of commitment to meiotic recombination and the Meiosis I to II transition; blocks trinucleotide repeat expansion; affects genome stability; disassembles Rad51p nucleoprotein filaments during meiotic recombination; stimulates Mus81p-Mms4p endonuclease activity independent of catalytic activity; ATPase and ssDNA translocating motor activities inhibited by Dmc1p; functional homolog of human RTEL1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL092W"}


id: YJL093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TOK1","product":"Outward-rectifier potassium channel of the plasma membrane; has two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin","secondary_identifier":"SGD:S000003629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL093C"}


id: YJL094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"KHA1","product":"Putative K+/H+ antiporter; involved in intracellular cation homeostasis; promotes copper binding to Fet3p multicopper oxidase; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000003630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL094C"}


id: YJL095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03753":null,"YJL095W":null},"has_protein_features":false,"name":"BCK1","ortholog_annotations":[{"gene_uniquename":"YJL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03753","reference_uniquename":"PMID:29761456"}],"product":"MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL095W"}


id: YJL096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01630":null,"YJL096W":null},"has_protein_features":false,"name":"MRPL49","ortholog_annotations":[{"gene_uniquename":"YJL096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01630","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL096W"}


id: YJL097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01300":null,"YJL097W":null},"has_protein_features":false,"name":"PHS1","ortholog_annotations":[{"gene_uniquename":"YJL097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01300","reference_uniquename":"PMID:29761456"}],"product":"Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane; involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003633","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL097W"}


id: YJL098W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04638":null,"YJL098W":null},"has_protein_features":false,"name":"SAP185","ortholog_annotations":[{"gene_uniquename":"YJL098W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04638","reference_uniquename":"PMID:29761456"}],"product":"Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003634","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL098W"}


id: YJL099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00916":null,"YJL099W":null},"has_protein_features":false,"name":"CHS6","ortholog_annotations":[{"gene_uniquename":"YJL099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00916","reference_uniquename":"PMID:29761456"}],"product":"Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; primary component of the Chs5/6 complex that binds directly to membranes; CHS6 has a paralog, BCH2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003635","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL099W"}


id: YJL100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01571":null,"YJL100W":null},"has_protein_features":false,"name":"LSB6","ortholog_annotations":[{"gene_uniquename":"YJL100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01571","reference_uniquename":"PMID:29761456"}],"product":"Type II phosphatidylinositol 4-kinase; binds Las17p, a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003636","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL100W"}


id: YJL101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00988":null,"YJL101C":null},"has_protein_features":false,"name":"GSH1","ortholog_annotations":[{"gene_uniquename":"YJL101C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00988","reference_uniquename":"PMID:29761456"}],"product":"Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003637","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL101C"}


id: YJL102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04862":null,"YJL102W":null},"has_protein_features":false,"name":"MEF2","ortholog_annotations":[{"gene_uniquename":"YJL102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04862","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial elongation factor involved in translational elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL102W"}


id: YJL103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GSM1","product":"Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis","secondary_identifier":"SGD:S000003639","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL103C"}


id: YJL104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00373":null,"YJL104W":null},"has_protein_features":false,"name":"PAM16","ortholog_annotations":[{"gene_uniquename":"YJL104W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00373","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the import motor (PAM complex); the PAM complex is a  component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003640","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL104W"}


id: YJL105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04396":null,"YJL105W":null},"has_protein_features":false,"name":"SET4","ortholog_annotations":[{"gene_uniquename":"YJL105W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04396","reference_uniquename":"PMID:29761456"}],"product":"Chromatin-associated protein involved in control of stress response; regulates response to oxidative stress; involved in control of gene repression in subtelomeric chromatin; contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003641","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL105W"}


id: YJL106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02712":null,"SJAG_03557":null,"YJL106W":null},"has_protein_features":false,"name":"IME2","ortholog_annotations":[{"gene_uniquename":"YJL106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02712","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03557","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase involved in activation of meiosis; associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p; human CDK2 can complement ime2 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL106W"}


id: YJL107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01770":null,"SJAG_04957":null,"YJL107C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJL107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01770","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04957","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL107C"}


id: YJL108C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01770":null,"SJAG_04957":null,"YJL108C":null},"has_protein_features":false,"name":"PRM10","ortholog_annotations":[{"gene_uniquename":"YJL108C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01770","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJL108C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04957","reference_uniquename":"PMID:26896847"}],"product":"Pheromone-regulated protein; proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000003644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL108C"}


id: YJL109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05187":null,"YJL109C":null},"has_protein_features":false,"name":"UTP10","ortholog_annotations":[{"gene_uniquename":"YJL109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05187","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL109C"}


id: YJL110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00792":null,"YJL110C":null},"has_protein_features":false,"name":"GZF3","ortholog_annotations":[{"gene_uniquename":"YJL110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00792","reference_uniquename":"PMID:29761456"}],"product":"GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL110C"}


id: YJL111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02926":null,"YJL111W":null},"has_protein_features":false,"name":"CCT7","ortholog_annotations":[{"gene_uniquename":"YJL111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02926","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL111W"}


id: YJL112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04732":null,"YJL112W":null},"has_protein_features":false,"name":"MDV1","ortholog_annotations":[{"gene_uniquename":"YJL112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04732","reference_uniquename":"PMID:29761456"}],"product":"Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the self-assembled oligomeric form of the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003648","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL112W"}


id: YJL115W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03366":null,"YJL115W":null},"has_protein_features":false,"name":"ASF1","ortholog_annotations":[{"gene_uniquename":"YJL115W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03366","reference_uniquename":"PMID:29761456"}],"product":"Nucleosome assembly factor; involved in chromatin assembly, disassembly; required for recovery after DSB repair; role in H3K56 acetylation required for expression homeostasis, buffering mRNA synthesis rate against gene dosage changes in S phase; anti-silencing protein, derepresses silent loci when overexpressed; role in regulating Ty1 transposition; relocalizes to cytosol under hypoxia; growth defect of asf1 null is functionally complemented by either human ASF1A or ASF1B","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL115W"}


id: YJL116C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02649":null,"SJAG_03295":null,"YJL116C":null},"has_protein_features":false,"name":"NCA3","ortholog_annotations":[{"gene_uniquename":"YJL116C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02649","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL116C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03295","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the vacuole; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL116C"}


id: YJL117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01899":null,"YJL117W":null},"has_protein_features":false,"name":"PHO86","ortholog_annotations":[{"gene_uniquename":"YJL117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01899","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003653","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL117W"}


id: YJL118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL118W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein","secondary_identifier":"SGD:S000003654","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL118W"}


id: YJL119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL119C"}


id: YJL120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO","secondary_identifier":"SGD:S000003656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL120W"}


id: YJL121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00501":null,"YJL121C":null},"has_protein_features":false,"name":"RPE1","ortholog_annotations":[{"gene_uniquename":"YJL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00501","reference_uniquename":"PMID:29761456"}],"product":"D-ribulose-5-phosphate 3-epimerase; catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL121C"}


id: YJL122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00932":null,"YJL122W":null},"has_protein_features":false,"name":"ALB1","ortholog_annotations":[{"gene_uniquename":"YJL122W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00932","reference_uniquename":"PMID:29761456"}],"product":"Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL122W"}


id: YJL123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01085":null,"YJL123C":null},"has_protein_features":false,"name":"MTC1","ortholog_annotations":[{"gene_uniquename":"YJL123C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01085","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL123C"}


id: YJL124C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04880":null,"YJL124C":null},"has_protein_features":false,"name":"LSM1","ortholog_annotations":[{"gene_uniquename":"YJL124C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04880","reference_uniquename":"PMID:29761456"}],"product":"Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; also enters the nucleus and positively regulates transcription initiation; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; binds to mRNAs under glucose starvation, most often in the 3' UTR; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL124C"}


id: YJL125C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02386":null,"YJL125C":null},"has_protein_features":false,"name":"GCD14","ortholog_annotations":[{"gene_uniquename":"YJL125C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02386","reference_uniquename":"PMID:29761456"}],"product":"Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL125C"}


id: YJL126W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04939":null,"YJL126W":null},"has_protein_features":false,"name":"NIT2","ortholog_annotations":[{"gene_uniquename":"YJL126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04939","reference_uniquename":"PMID:29761456"}],"product":"Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL126W"}


id: YJL127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPT10","product":"Histone H3 acetylase with a role in transcriptional regulation; sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near TATA box; involved in S phase-specific acetylation of H3K56 at histone promoters, which is required for recruitment of SWI/SNF nucleosome remodeling complex and subsequent transcription","secondary_identifier":"SGD:S000003663","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL127C"}


id: YJL127C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05268":null,"YJL127C-B":null},"has_protein_features":false,"name":"MCO6","ortholog_annotations":[{"gene_uniquename":"YJL127C-B","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05268","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein of unknown function; identified based on homology to the filamentous fungus, <i>Ashbya gossypii</i>; SWAT-GFP and seamless-GFP fusion proteins localize to the mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL127C-B"}


id: YJL127W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007612","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL127W-A"}


id: YJL128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02342":null,"YJL128C":null},"has_protein_features":false,"name":"PBS2","ortholog_annotations":[{"gene_uniquename":"YJL128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02342","reference_uniquename":"PMID:29761456"}],"product":"MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003664","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL128C"}


id: YJL129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01353":null,"SJAG_02883":null,"YJL129C":null},"has_protein_features":false,"name":"TRK1","ortholog_annotations":[{"gene_uniquename":"YJL129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01353","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02883","reference_uniquename":"PMID:29761456"}],"product":"Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003665","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL129C"}


id: YJL130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00964":null,"YJL130C":null},"has_protein_features":false,"name":"URA2","ortholog_annotations":[{"gene_uniquename":"YJL130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00964","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003666","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL130C"}


id: YJL131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04635":null,"YJL131C":null},"has_protein_features":false,"name":"AIM23","ortholog_annotations":[{"gene_uniquename":"YJL131C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04635","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; interacts with mitochondrial ribosomal small subunit; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003667","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL131C"}


id: YJL132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene","secondary_identifier":"SGD:S000003668","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL132W"}


id: YJL133C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DPI8","product":"Putative mitochondrial protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000028805","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL133C-A"}


id: YJL133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02473":null,"SJAG_04737":null,"YJL133W":null},"has_protein_features":false,"name":"MRS3","ortholog_annotations":[{"gene_uniquename":"YJL133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02473","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04737","reference_uniquename":"PMID:29761456"}],"product":"Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL133W"}


id: YJL134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04986":null,"YJL134W":null},"has_protein_features":false,"name":"LCB3","ortholog_annotations":[{"gene_uniquename":"YJL134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04986","reference_uniquename":"PMID:29761456"}],"product":"Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003670","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL134W"}


id: YJL135W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3","secondary_identifier":"SGD:S000003671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL135W"}


id: YJL136C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04174":null,"YJL136C":null},"has_protein_features":false,"name":"RPS21B","ortholog_annotations":[{"gene_uniquename":"YJL136C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04174","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL136C"}


id: YJL136W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by SAGE","secondary_identifier":"SGD:S000028806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL136W-A"}


id: YJL137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GLG2","product":"Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL137C"}


id: YJL138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04772":null,"YJL138C":null},"has_protein_features":false,"name":"TIF2","ortholog_annotations":[{"gene_uniquename":"YJL138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04772","reference_uniquename":"PMID:29761456"}],"product":"Translation initiation factor eIF4A; DEAD-box RNA helicase that couples ATPase activity to mRNA binding and unwinding; ATP hydrolysis accelerates the recruitment of mRNA during 48S preinitiation complex (PIC) assembly; ATPase activity stimulated by either eIF4G1 or by the PIC in an eIF3g and eIFGi subunit-dependent manner, independent of eIF4E and eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E and eIF4G; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003674","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL138C"}


id: YJL139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"YJL139C":null},"has_protein_features":false,"name":"YUR1","ortholog_annotations":[{"gene_uniquename":"YJL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"}],"product":"Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003675","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL139C"}


id: YJL140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00458":null,"YJL140W":null},"has_protein_features":false,"name":"RPB4","ortholog_annotations":[{"gene_uniquename":"YJL140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00458","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL140W"}


id: YJL141C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02392":null,"SJAG_03887":null,"SJAG_04980":null,"YJL141C":null},"has_protein_features":false,"name":"YAK1","ortholog_annotations":[{"gene_uniquename":"YJL141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02392","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03887","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04980","reference_uniquename":"PMID:29761456"}],"product":"Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL141C"}


id: YJL142C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IRC9","product":"Putative protein of unknown function; partially overlaps verified gene YAK1/YJL141C but does not share all phenotypes; null mutant displays increased levels of spontaneous Rad52p foci, increased sporulation efficiency, and small defect in vacuolar fragmentation","secondary_identifier":"SGD:S000003678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL142C"}


id: YJL143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01879":null,"YJL143W":null},"has_protein_features":false,"name":"TIM17","ortholog_annotations":[{"gene_uniquename":"YJL143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01879","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the TIM23 complex; with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core Translocase of the Inner Mitochondrial membrane (TIM23 complex)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003679","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL143W"}


id: YJL144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ROQ1","product":"Ub-ligase substrate-specificity factor; proteolytically-cleaved form acts as a pseudosubstrate, binding and altering the substrate specificity of Ubr1p towards misfolded and native ER membrane and cytosolic proteins, as part of the stress-induced homeostatically regulated protein degradation (SHRED) pathway; hydrophilin essential during desiccation-rehydration; induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003680","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL144W"}


id: YJL145W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SFH5","product":"Unusual phosphatidylinositol transfer protein (PITP) that binds heme; similar to Sec14p; founding member of conserved class of fungal hemoproteins; exhibits PI- but not PC-transfer activity; localizes to peripheral endoplasmic reticulum, cytosol, and microsomes; partially relocalizes to plasma membrane upon DNA replication stress","secondary_identifier":"SGD:S000003681","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL145W"}


id: YJL146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IDS2","product":"Protein involved in modulation of Ime2p activity during meiosis; appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation","secondary_identifier":"SGD:S000003682","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL146W"}


id: YJL147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SMT1","product":"Translational repressor of the mitochondrial ATP6/8 mRNA; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage","secondary_identifier":"SGD:S000003683","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL147C"}


id: YJL148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03468":null,"YJL148W":null},"has_protein_features":false,"name":"RPA34","ortholog_annotations":[{"gene_uniquename":"YJL148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03468","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase I subunit A34.5; essential for nucleolar assembly and for high polymerase loading rate; nucleolar localization depends on Rpa49p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL148W"}


id: YJL149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DAS1","product":"Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C","secondary_identifier":"SGD:S000003685","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL149W"}


id: YJL150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003686","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL150W"}


id: YJL151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00372":null,"YJL151C":null},"has_protein_features":false,"name":"SNA3","ortholog_annotations":[{"gene_uniquename":"YJL151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00372","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003687","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL151C"}


id: YJL152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003688","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL152W"}


id: YJL153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"INO1","product":"Inositol-3-phosphate synthase; involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element","secondary_identifier":"SGD:S000003689","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL153C"}


id: YJL154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01039":null,"YJL154C":null},"has_protein_features":false,"name":"VPS35","ortholog_annotations":[{"gene_uniquename":"YJL154C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01039","reference_uniquename":"PMID:29761456"}],"product":"Endosomal subunit of membrane-associated retromer complex; required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p; overexpression of wild-type human VPS35 or Parkinson's-associated vps35-D686N or vps35-P299S variants complements Ni2+ resistance and Cd2+ sensitivity of yeast vps35 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003690","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL154C"}


id: YJL155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02713":null,"YJL155C":null},"has_protein_features":false,"name":"FBP26","ortholog_annotations":[{"gene_uniquename":"YJL155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02713","reference_uniquename":"PMID:29761456"}],"product":"Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003691","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL155C"}


id: YJL156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SSY5","product":"Serine protease of SPS plasma membrane amino acid sensor system; contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p; other members are Ssy1p and Ptr3p","secondary_identifier":"SGD:S000003692","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL156C"}


id: YJL156W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL156W-A"}


id: YJL157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FAR1","product":"CDK inhibitor and nuclear anchor; during the cell cycle Far1p sequesters the GEF Cdc24p in the nucleus; phosphorylation by Cdc28p-Cln results in SCFCdc4 complex-mediated ubiquitin-dependent degradation, releasing Cdc24p for export and activation of GTPase Cdc42p; in response to pheromone, phosphorylation of Far1p by MAPK Fus3p results in association with, and inhibition of Cdc28p-Cln, as well as Msn5p mediated nuclear export of Far1p-Cdc24p, targeting Cdc24p to polarity sites","secondary_identifier":"SGD:S000003693","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL157C"}


id: YJL158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CIS3","product":"Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family","secondary_identifier":"SGD:S000003694","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL158C"}


id: YJL159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HSP150","product":"O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003695","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL159W"}


id: YJL160C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PIR5","product":"Putative protein of unknown function; member of the PIR (Proteins with Internal Repeats) family of cell wall proteins; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, and mCherry fusion localizes to the vacuole; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003696","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL160C"}


id: YJL161W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FMP33","product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000003697","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL161W"}


id: YJL162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02518":null,"SJAG_03052":null,"YJL162C":null},"has_protein_features":false,"name":"JJJ2","ortholog_annotations":[{"gene_uniquename":"YJL162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02518","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03052","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; contains a J-domain, which is a region with homology to the E. coli DnaJ protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003698","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL162C"}


id: YJL163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03447":null,"YJL163C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJL163C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03447","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003699","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL163C"}


id: YJL164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04312":null,"YJL164C":null},"has_protein_features":false,"name":"TPK1","ortholog_annotations":[{"gene_uniquename":"YJL164C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04312","reference_uniquename":"PMID:29761456"}],"product":"cAMP-dependent protein kinase catalytic subunit; role in nutrient-stimulated growth via Ras-cAMP signaling; inhibited by regulatory subunit Bcy1p in cAMPs absence; phosphorylates and inhibits Whi3p to promote G1/S phase passage; phosphorylates Nej1p to regulate nonhomologous end joining (NHEJ); impairs mitochondrial import of pre-Tom40p via phosphorylation under non-respiratory conditions; partially redundant with Tpk2p and Tpk3p; human homolog PRKACB regulates NHEJ via NHEJ1 phosphorylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003700","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL164C"}


id: YJL165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HAL5","product":"Snf1p-related nutrient-responsive protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003701","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL165C"}


id: YJL166W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00080":null,"YJL166W":null},"has_protein_features":false,"name":"QCR8","ortholog_annotations":[{"gene_uniquename":"YJL166W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00080","reference_uniquename":"PMID:29761456"}],"product":"Subunit 8 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003702","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL166W"}


id: YJL167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00580":null,"SJAG_03352":null,"YJL167W":null},"has_protein_features":false,"name":"ERG20","ortholog_annotations":[{"gene_uniquename":"YJL167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00580","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03352","reference_uniquename":"PMID:29761456"}],"product":"Farnesyl pyrophosphate synthetase; has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003703","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL167W"}


id: YJL168C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02873":null,"YJL168C":null},"has_protein_features":false,"name":"SET2","ortholog_annotations":[{"gene_uniquename":"YJL168C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02873","reference_uniquename":"PMID:29761456"}],"product":"Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain(CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL168C"}


id: YJL169W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2","secondary_identifier":"SGD:S000003705","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL169W"}


id: YJL170C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ASG7","product":"Protein that regulates signaling from G protein beta subunit Ste4p; contributes to relocalization of Ste4p within the cell; specific to a-cells and induced by alpha-factor","secondary_identifier":"SGD:S000003706","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL170C"}


id: YJL171C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00876":null,"YJL171C":null},"has_protein_features":false,"name":"TOH1","ortholog_annotations":[{"gene_uniquename":"YJL171C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00876","reference_uniquename":"PMID:29761456"}],"product":"GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003707","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL171C"}


id: YJL172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03586":null,"YJL172W":null},"has_protein_features":false,"name":"CPS1","ortholog_annotations":[{"gene_uniquename":"YJL172W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03586","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar carboxypeptidase S; expression is induced under low-nitrogen conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003708","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL172W"}


id: YJL173C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03722":null,"YJL173C":null},"has_protein_features":false,"name":"RFA3","ortholog_annotations":[{"gene_uniquename":"YJL173C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03722","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003709","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL173C"}


id: YJL174W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04073":null,"YJL174W":null},"has_protein_features":false,"name":"KRE9","ortholog_annotations":[{"gene_uniquename":"YJL174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04073","reference_uniquename":"PMID:29761456"}],"product":"Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003710","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL174W"}


id: YJL175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor","secondary_identifier":"SGD:S000003711","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL175W"}


id: YJL176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02447":null,"SJAG_02589":null,"YJL176C":null},"has_protein_features":false,"name":"SWI3","ortholog_annotations":[{"gene_uniquename":"YJL176C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02447","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL176C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02589","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; contains SANT domain that is required for SWI/SNF assembly; is essential for displacement of histone H2A-H2B dimers during ATP-dependent remodeling; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003712","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL176C"}


id: YJL177W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00940":null,"SJAG_01721":null,"YJL177W":null},"has_protein_features":false,"name":"RPL17B","ortholog_annotations":[{"gene_uniquename":"YJL177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00940","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01721","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L17B; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003713","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL177W"}


id: YJL178C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATG27","product":"Type I membrane protein involved in autophagy and the Cvt pathway; may be involved in membrane delivery to the phagophore assembly site","secondary_identifier":"SGD:S000003714","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL178C"}


id: YJL179W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03463":null,"YJL179W":null},"has_protein_features":false,"name":"PFD1","ortholog_annotations":[{"gene_uniquename":"YJL179W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03463","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heterohexameric prefoldin; prefoldin binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003715","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL179W"}


id: YJL180C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01503":null,"YJL180C":null},"has_protein_features":false,"name":"ATP12","ortholog_annotations":[{"gene_uniquename":"YJL180C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01503","reference_uniquename":"PMID:29761456"}],"product":"Assembly factor for F1 sector of mitochondrial F1F0 ATP synthase; conserved protein; required for assembly of alpha and beta subunits into F1 sector of mitochondrial F1F0 ATP synthase; human homolog ATPAF2 can complement yeast atp12 mutant; mutation of human homolog reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003716","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL180C"}


id: YJL181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RBH1","product":"Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; contains a PH-like domain; RBH1 has a paralog, RBH2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003717","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL181W"}


id: YJL182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W","secondary_identifier":"SGD:S000003718","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL182C"}


id: YJL183W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01972":null,"SJAG_02996":null,"SJAG_03555":null,"SJAG_03790":null,"SJAG_03871":null,"SJAG_04095":null,"SJAG_04401":null,"YJL183W":null},"has_protein_features":false,"name":"MNN11","ortholog_annotations":[{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01972","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02996","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03555","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03790","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03871","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04095","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04401","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a Golgi mannosyltransferase complex; this complex also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003719","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL183W"}


id: YJL184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06560":null,"YJL184W":null},"has_protein_features":false,"name":"GON7","ortholog_annotations":[{"gene_uniquename":"YJL184W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06560","reference_uniquename":"PMID:29761456"}],"product":"Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; implicated in osmotic stress response; other complex members are Kae1p, Cgi121p, Pcc1p, and Bud32p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003720","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL184W"}


id: YJL185C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATG36","product":"Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene","secondary_identifier":"SGD:S000003721","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL185C"}


id: YJL186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MNN5","product":"Alpha-1,2-mannosyltransferase; responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment","secondary_identifier":"SGD:S000003722","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL186W"}


id: YJL187C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03854":null,"SJAG_04280":null,"YJL187C":null},"has_protein_features":false,"name":"SWE1","ortholog_annotations":[{"gene_uniquename":"YJL187C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03854","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL187C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04280","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase that regulates the G2/M transition; negative regulator of the Cdc28p kinase; morphogenesis checkpoint kinase; positive regulator of sphingolipid biosynthesis via Orm2p; phosphorylates a tyrosine residue in the N-terminus of Hsp90 in a cell-cycle associated manner, thus modulating the ability of Hsp90 to chaperone a selected clientele; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003723","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL187C"}


id: YJL188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BUD19","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay","secondary_identifier":"SGD:S000003724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL188C"}


id: YJL189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03364":null,"YJL189W":null},"has_protein_features":false,"name":"RPL39","ortholog_annotations":[{"gene_uniquename":"YJL189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03364","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003725","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL189W"}


id: YJL190C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01512":null,"SJAG_03762":null,"YJL190C":null},"has_protein_features":false,"name":"RPS22A","ortholog_annotations":[{"gene_uniquename":"YJL190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01512","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03762","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003726","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL190C"}


id: YJL191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01548":null,"SJAG_03424":null,"YJL191W":null},"has_protein_features":false,"name":"RPS14B","ortholog_annotations":[{"gene_uniquename":"YJL191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01548","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03424","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003727","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL191W"}


id: YJL192C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00277":null,"YJL192C":null},"has_protein_features":false,"name":"SOP4","ortholog_annotations":[{"gene_uniquename":"YJL192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00277","reference_uniquename":"PMID:29761456"}],"product":"ER-membrane protein; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5 of TOM (Translocase of the Mitochondrial Outer Membrane) complex; suppressor of pma1-7, deletion of SOP4 slows down export of wild-type Pma1p and Pma1-7 from the ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003728","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL192C"}


id: YJL193W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00276":null,"YJL193W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJL193W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00276","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003729","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL193W"}


id: YJL194W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02074":null,"YJL194W":null},"has_protein_features":false,"name":"CDC6","ortholog_annotations":[{"gene_uniquename":"YJL194W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02074","reference_uniquename":"PMID:29761456"}],"product":"Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress; degraded in response to plasma membrane stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003730","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL194W"}


id: YJL195C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6","secondary_identifier":"SGD:S000003731","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL195C"}


id: YJL196C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01356":null,"SJAG_02885":null,"YJL196C":null},"has_protein_features":false,"name":"ELO1","ortholog_annotations":[{"gene_uniquename":"YJL196C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01356","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL196C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02885","reference_uniquename":"PMID:29761456"}],"product":"Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, ELO2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003732","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL196C"}


id: YJL197C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL197C/UBP12","secondary_identifier":"SGD:S000028839","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL197C-A"}


id: YJL197W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04215":null,"SJAG_04651":null,"YJL197W":null},"has_protein_features":false,"name":"UBP12","ortholog_annotations":[{"gene_uniquename":"YJL197W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04215","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL197W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04651","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003733","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL197W"}


id: YJL198W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01059":null,"YJL198W":null},"has_protein_features":false,"name":"PHO90","ortholog_annotations":[{"gene_uniquename":"YJL198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01059","reference_uniquename":"PMID:29761456"}],"product":"Low-affinity phosphate transporter; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003734","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL198W"}


id: YJL199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MBB1","product":"Protein of unknown function; conserved among S. cerevisiae strains, not conserved in closely related Saccharomyces species; protein detected via large-scale protein-protein interaction studies and enrichment-based proteogenomics; YJL199C is not an essential gene","secondary_identifier":"SGD:S000003735","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL199C"}


id: YJL200C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01630":null,"YJL200C":null},"has_protein_features":false,"name":"ACO2","ortholog_annotations":[{"gene_uniquename":"YJL200C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01630","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003736","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL200C"}


id: YJL201W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ECM25","product":"Endocytic site protein required for stress-induced cell elongation; may link the polarization signal with the endocytic machinery to facilitate adaptive morphogenesis under conditions of stress; interacts with the polarity regulator Cdc42p, the SH3 domains of actin patch components and actin filaments; contains a Rho-GAP domain lacking the catalytic arginine finger, PXXP motifs and an xACT (F-actin binding) motif; promoter contains a consensus binding sequence for transcription factor Abf1p","secondary_identifier":"SGD:S000003737","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL201W"}


id: YJL202C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex","secondary_identifier":"SGD:S000003738","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL202C"}


id: YJL203W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04318":null,"YJL203W":null},"has_protein_features":false,"name":"PRP21","ortholog_annotations":[{"gene_uniquename":"YJL203W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04318","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SF3a splicing factor complex; required for spliceosome assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003739","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL203W"}


id: YJL204C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02753":null,"YJL204C":null},"has_protein_features":false,"name":"RCY1","ortholog_annotations":[{"gene_uniquename":"YJL204C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02753","reference_uniquename":"PMID:29761456"}],"product":"F-box protein involved in recycling endocytosed proteins; involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth; direct interaction with C-terminal cytoplasmic region of Drs2p plays an important role for Drs2p function in endocytic recycling pathway; required for turnover of histone H3 variant Cse4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003740","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL204C"}


id: YJL205C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_07004":null,"YJL205C":null},"has_protein_features":false,"name":"NCE101","ortholog_annotations":[{"gene_uniquename":"YJL205C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07004","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; involved in secretion of proteins that lack classical secretory signal sequences; SWAT-GFP and mCherry fusion proteins localize to the cytosol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003742","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL205C"}


id: YJL206C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment","secondary_identifier":"SGD:S000003741","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL206C"}


id: YJL207C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03504":null,"YJL207C":null},"has_protein_features":false,"name":"LAA1","ortholog_annotations":[{"gene_uniquename":"YJL207C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03504","reference_uniquename":"PMID:29761456"}],"product":"AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003743","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL207C"}


id: YJL208C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01948":null,"YJL208C":null},"has_protein_features":false,"name":"NUC1","ortholog_annotations":[{"gene_uniquename":"YJL208C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01948","reference_uniquename":"PMID:29761456"}],"product":"Major mitochondrial nuclease; has RNAse and DNA endo- and exonucleolytic activities; roles in mitochondrial recombination, apoptosis and maintenance of polyploidy; involved in fragmentation of genomic DNA during PND (programmed nuclear destruction); encodes ortholog of mammalian endoG","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003744","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL208C"}


id: YJL209W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CBP1","product":"Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress","secondary_identifier":"SGD:S000003745","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL209W"}


id: YJL210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEX2","product":"RING-finger peroxin and E3 ubiquitin ligase; peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import","secondary_identifier":"SGD:S000003746","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL210W"}


id: YJL211C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2","secondary_identifier":"SGD:S000003747","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL211C"}


id: YJL212C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00922":null,"SJAG_01660":null,"YJL212C":null},"has_protein_features":false,"name":"OPT1","ortholog_annotations":[{"gene_uniquename":"YJL212C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00922","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL212C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01660","reference_uniquename":"PMID:29761456"}],"product":"Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003748","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL212C"}


id: YJL213W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p","secondary_identifier":"SGD:S000003749","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL213W"}


id: YJL214W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YJL214W":null},"has_protein_features":false,"name":"HXT8","ortholog_annotations":[{"gene_uniquename":"YJL214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJL214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJL214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function with similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003750","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL214W"}


id: YJL215C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003751","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL215C"}


id: YJL216C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IMA5","product":"Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; most distant member of the IMA isomaltase family, but with similar catalytic properties as Ima1p and Ima2p; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose; can cleave alpha-1,3 linkage of nigerose and turanose and alpha-1,5 linkage of leucrose and is very sensitive to temperature in vitro","secondary_identifier":"SGD:S000003752","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL216C"}


id: YJL217W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"REE1","product":"Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle","secondary_identifier":"SGD:S000003753","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL217W"}


id: YJL218W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05413":null,"YJL218W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJL218W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05413","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein, putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in OAF1/PIP2-dependent manner; promoter contains oleate response element consensus sequence; non-essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003754","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL218W"}


id: YJL219W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YJL219W":null},"has_protein_features":false,"name":"HXT9","ortholog_annotations":[{"gene_uniquename":"YJL219W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL219W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJL219W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL219W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL219W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL219W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJL219W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Putative hexose transporter that is nearly identical to Hxt11p; has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003755","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL219W"}


id: YJL220W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2","secondary_identifier":"SGD:S000003756","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL220W"}


id: YJL221C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IMA4","product":"Alpha-glucosidase; weak, but broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima4p overexpression allows the ima1 null mutant to grow on isomaltose; identical to IMA3","secondary_identifier":"SGD:S000003757","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL221C"}


id: YJL222W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01488":null,"YJL222W":null},"has_protein_features":false,"name":"VTH2","ortholog_annotations":[{"gene_uniquename":"YJL222W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01488","reference_uniquename":"PMID:29761456"}],"product":"Putative membrane glycoprotein; has strong similarity to Vth1p and Pep1p/Vps10p; may be involved in vacuolar protein sorting","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003758","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL222W"}


id: YJL222W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000028663","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL222W-A"}


id: YJL222W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000028664","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL222W-B"}


id: YJL223C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU1","product":"Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; active during alcoholic fermentation; regulated by anaerobiosis, negatively regulated by oxygen; repressed by heme; identical to Pau14p","secondary_identifier":"SGD:S000003759","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL223C"}


id: YJL225C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative Y' element ATP-dependent helicase","secondary_identifier":"SGD:S000003760","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL225C"}


id: YJL225W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YJL225C","secondary_identifier":"SGD:S000028665","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL225W-A"}


id: YJR001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AVT1","product":"Vacuolar transporter; imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters","secondary_identifier":"SGD:S000003761","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR001W"}


id: YJR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02681":null,"YJR002W":null},"has_protein_features":false,"name":"MPP10","ortholog_annotations":[{"gene_uniquename":"YJR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02681","reference_uniquename":"PMID:29761456"}],"product":"Component of the SSU processome and 90S preribosome; required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003762","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR002W"}


id: YJR003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MRX12","product":"Protein that associates with mitochondrial ribosome; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis","secondary_identifier":"SGD:S000003763","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR003C"}


id: YJR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SAG1","product":"Alpha-agglutinin of alpha-cells; binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor","secondary_identifier":"SGD:S000003764","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR004C"}


id: YJR005C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03924":null,"YJR005C-A":null},"has_protein_features":false,"name":"LSO1","ortholog_annotations":[{"gene_uniquename":"YJR005C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03924","reference_uniquename":"PMID:29761456"}],"product":"Protein with a potential role in response to iron deprivation; transcription increases during iron deprivation and during treatment with 2-(6-benzyl-2-pyridyl)quinazoline (BPQ) and copper; regulated by Aft1p and, to a lesser extent, by Aft2p; originally identified as a syntenic homolog of an Ashbya gossypii gene; localizes to nucleus and cytoplasm, and nuclear localization is enhanced under iron-replete conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR005C-A"}


id: YJR005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00104":null,"SJAG_02453":null,"YJR005W":null},"has_protein_features":false,"name":"APL1","ortholog_annotations":[{"gene_uniquename":"YJR005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00104","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02453","reference_uniquename":"PMID:26896847"}],"product":"Beta-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003765","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR005W"}


id: YJR006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04877":null,"YJR006W":null},"has_protein_features":false,"name":"POL31","ortholog_annotations":[{"gene_uniquename":"YJR006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04877","reference_uniquename":"PMID:29761456"}],"product":"Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair; forms a complex with Rev3p, Rev7p and Pol32p; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003766","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR006W"}


id: YJR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03629":null,"YJR007W":null},"has_protein_features":false,"name":"SUI2","ortholog_annotations":[{"gene_uniquename":"YJR007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03629","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003767","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR007W"}


id: YJR008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01220":null,"YJR008W":null},"has_protein_features":false,"name":"MHO1","ortholog_annotations":[{"gene_uniquename":"YJR008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01220","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003768","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR008W"}


id: YJR009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00027":null,"SJAG_02135":null,"SJAG_02945":null,"SJAG_03828":null,"SJAG_03903":null,"SJAG_06621":null,"SJAG_06622":null,"YJR009C":null},"has_protein_features":false,"name":"TDH2","ortholog_annotations":[{"gene_uniquename":"YJR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00027","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02135","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02945","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03828","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03903","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06621","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06622","reference_uniquename":"PMID:29761456"}],"product":"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides are active against a wide variety of wine-related yeasts and bateria; TDH2 has a paralog, TDH3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003769","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR009C"}


id: YJR010C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01750":null,"YJR010C-A":null},"has_protein_features":false,"name":"SPC1","ortholog_annotations":[{"gene_uniquename":"YJR010C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01750","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003770","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR010C-A"}


id: YJR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03475":null,"YJR010W":null},"has_protein_features":false,"name":"MET3","ortholog_annotations":[{"gene_uniquename":"YJR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03475","reference_uniquename":"PMID:29761456"}],"product":"ATP sulfurylase; catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003771","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR010W"}


id: YJR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000003772","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR011C"}


id: YJR012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; null mutant is viable","secondary_identifier":"SGD:S000003773","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR012C"}


id: YJR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03115":null,"YJR013W":null},"has_protein_features":false,"name":"GPI14","ortholog_annotations":[{"gene_uniquename":"YJR013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03115","reference_uniquename":"PMID:29761456"}],"product":"Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I; involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003774","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR013W"}


id: YJR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01487":null,"YJR014W":null},"has_protein_features":false,"name":"TMA22","ortholog_annotations":[{"gene_uniquename":"YJR014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01487","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003775","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR014W"}


id: YJR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; localizes to endoplasmic reticulum and cytoplasm; null mutant exhibits abnormal lipid metabolic phenotype; predicted to encode a membrane transporter based on phylogenetic analysis; not an essential gene; YJR015W has a paralog, SNG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003776","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR015W"}


id: YJR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04098":null,"YJR016C":null},"has_protein_features":false,"name":"ILV3","ortholog_annotations":[{"gene_uniquename":"YJR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04098","reference_uniquename":"PMID:29761456"}],"product":"Dihydroxyacid dehydratase; putative 2Fe-2S protein; catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003777","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR016C"}


id: YJR017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02551":null,"YJR017C":null},"has_protein_features":false,"name":"ESS1","ortholog_annotations":[{"gene_uniquename":"YJR017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02551","reference_uniquename":"PMID:29761456"}],"product":"Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated S/T residues N-terminal to proline; regulates phosphorylation of RNAPII large subunit (Rpo21p) C-terminal domain (CTD) at Ser7; associates with phospho-Ser5 form of RNAPII in vivo; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription, trimethylation of histone H3; human ortholog PIN1 can complement yeast null and ts mutants","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003778","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR017C"}


id: YJR018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003779","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR018W"}


id: YJR019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TES1","product":"Peroxisomal acyl-CoA thioesterase; likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids","secondary_identifier":"SGD:S000003780","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR019C"}


id: YJR020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003781","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR020W"}


id: YJR021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"REC107","product":"Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation","secondary_identifier":"SGD:S000003782","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR021C"}


id: YJR022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01819":null,"YJR022W":null},"has_protein_features":false,"name":"LSM8","ortholog_annotations":[{"gene_uniquename":"YJR022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01819","reference_uniquename":"PMID:29761456"}],"product":"Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003783","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR022W"}


id: YJR023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing","secondary_identifier":"SGD:S000003784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR023C"}


id: YJR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02293":null,"SJAG_02689":null,"YJR024C":null},"has_protein_features":false,"name":"MDE1","ortholog_annotations":[{"gene_uniquename":"YJR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02293","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02689","reference_uniquename":"PMID:29761456"}],"product":"5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003785","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR024C"}


id: YJR025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BNA1","product":"3-hydroxyanthranilic acid dioxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p","secondary_identifier":"SGD:S000003786","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR025C"}


id: YJR030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RBH2","product":"Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; non-essential gene; contains a PH-like domain; RBH2 has a paralog, RBH1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003791","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR030C"}


id: YJR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00858":null,"YJR031C":null},"has_protein_features":false,"name":"GEA1","ortholog_annotations":[{"gene_uniquename":"YJR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00858","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003792","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR031C"}


id: YJR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04352":null,"YJR032W":null},"has_protein_features":false,"name":"CPR7","ortholog_annotations":[{"gene_uniquename":"YJR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04352","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; plays a role in determining prion variants","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003793","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR032W"}


id: YJR033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00301":null,"YJR033C":null},"has_protein_features":false,"name":"RAV1","ortholog_annotations":[{"gene_uniquename":"YJR033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00301","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RAVE complex (Rav1p, Rav2p, Skp1p); the RAVE complex promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003794","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR033C"}


id: YJR034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05199":null,"YJR034W":null},"has_protein_features":false,"name":"PET191","ortholog_annotations":[{"gene_uniquename":"YJR034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05199","reference_uniquename":"PMID:29761456"}],"product":"Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003795","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR034W"}


id: YJR035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04114":null,"YJR035W":null},"has_protein_features":false,"name":"RAD26","ortholog_annotations":[{"gene_uniquename":"YJR035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04114","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in transcription-coupled nucleotide excision repair; repairs UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003796","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR035W"}


id: YJR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05264":null,"YJR036C":null},"has_protein_features":false,"name":"HUL4","ortholog_annotations":[{"gene_uniquename":"YJR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05264","reference_uniquename":"PMID:29761456"}],"product":"Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003797","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR036C"}


id: YJR037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces","secondary_identifier":"SGD:S000003798","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR037W"}


id: YJR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003799","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR038C"}


id: YJR039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MLO127","product":"Mitochondrial protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000003800","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR039W"}


id: YJR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GEF1","product":"Voltage-gated chloride channel; localized to the golgi, the endosomal system, and plasma membrane; involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism","secondary_identifier":"SGD:S000003801","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR040W"}


id: YJR041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03888":null,"YJR041C":null},"has_protein_features":false,"name":"URB2","ortholog_annotations":[{"gene_uniquename":"YJR041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03888","reference_uniquename":"PMID:29761456"}],"product":"Protein required for normal metabolism of the rRNA primary transcript; nucleolar protein; proposed to be involved in ribosome biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003802","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR041C"}


id: YJR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00471":null,"YJR042W":null},"has_protein_features":false,"name":"NUP85","ortholog_annotations":[{"gene_uniquename":"YJR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00471","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003803","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR042W"}


id: YJR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00814":null,"YJR043C":null},"has_protein_features":false,"name":"POL32","ortholog_annotations":[{"gene_uniquename":"YJR043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00814","reference_uniquename":"PMID:29761456"}],"product":"Third subunit of DNA polymerase delta; involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; forms a complex with Rev3p, Rev7p and Pol31p; interacts with Hys2p, PCNA (Pol30p), and Pol1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003804","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR043C"}


id: YJR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_07012":null,"YJR044C":null},"has_protein_features":false,"name":"VPS55","ortholog_annotations":[{"gene_uniquename":"YJR044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07012","reference_uniquename":"PMID:29761456"}],"product":"Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003805","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR044C"}


id: YJR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01615":null,"YJR045C":null},"has_protein_features":false,"name":"SSC1","ortholog_annotations":[{"gene_uniquename":"YJR045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01615","reference_uniquename":"PMID:29761456"}],"product":"Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR045C"}


id: YJR046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02607":null,"YJR046W":null},"has_protein_features":false,"name":"TAH11","ortholog_annotations":[{"gene_uniquename":"YJR046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02607","reference_uniquename":"PMID:29761456"}],"product":"DNA replication licensing factor; required for pre-replication complex assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR046W"}


id: YJR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02189":null,"SJAG_02812":null,"YJR047C":null},"has_protein_features":false,"name":"ANB1","ortholog_annotations":[{"gene_uniquename":"YJR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02189","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02812","reference_uniquename":"PMID:29761456"}],"product":"Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication; human EIF5A complements the inviability of the yeast hyp2 anb1 double null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR047C"}


id: YJR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02744":null,"YJR048W":null},"has_protein_features":false,"name":"CYC1","ortholog_annotations":[{"gene_uniquename":"YJR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02744","reference_uniquename":"PMID:29761456"}],"product":"Cytochrome c, isoform 1; also known as iso-1-cytochrome c; electron carrier of mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication; human homolog CYC1 can complement yeast null mutant; mutations in human CYC1 cause insulin-responsive hyperglycemia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003809","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR048W"}


id: YJR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01566":null,"SJAG_01582":null,"YJR049C":null},"has_protein_features":false,"name":"UTR1","ortholog_annotations":[{"gene_uniquename":"YJR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01566","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01582","reference_uniquename":"PMID:29761456"}],"product":"ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003810","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR049C"}


id: YJR050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01214":null,"YJR050W":null},"has_protein_features":false,"name":"ISY1","ortholog_annotations":[{"gene_uniquename":"YJR050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01214","reference_uniquename":"PMID:29761456"}],"product":"Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs; interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR050W"}


id: YJR051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00203":null,"YJR051W":null},"has_protein_features":false,"name":"OSM1","ortholog_annotations":[{"gene_uniquename":"YJR051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00203","reference_uniquename":"PMID:29761456"}],"product":"Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; acts as electron acceptor in mitochondrial intermembrane space; has two translation start sites, one at the annotated start codon which produces an ER-targeted form required for anaerobic growth, and one at codon 32 which produces a mitochondrially-targeted form; OSM1 has a paralog, FRD1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR051W"}


id: YJR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03612":null,"YJR052W":null},"has_protein_features":false,"name":"RAD7","ortholog_annotations":[{"gene_uniquename":"YJR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03612","reference_uniquename":"PMID:29761456"}],"product":"Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad16p) during NER; required for repair of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003813","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR052W"}


id: YJR053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04943":null,"YJR053W":null},"has_protein_features":false,"name":"BFA1","ortholog_annotations":[{"gene_uniquename":"YJR053W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04943","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p; contributes to GAP activity, inactivating Tem1 by stimulating GTP hydrolysis following damage or misalignment of the mitotic spindle; functions as a guanine-nucleotide exchange inhibitor (GDI) for Tem1p; involved in multiple cell cycle checkpoint pathways that control mitotic exit; required when telomeres are damaged, but not for all types of chromosomal DNA damage; phosphorylated by the Polo-like kinase Cdc5p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003814","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR053W"}


id: YJR054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"KCH1","product":"Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; localized to sites of polarized growth; member of a fungal-specific gene family; potential Cdc28p substrate; KCH1 has a paralog, PRM6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003815","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR054W"}


id: YJR055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05223":null,"YJR055W":null},"has_protein_features":false,"name":"HIT1","ortholog_annotations":[{"gene_uniquename":"YJR055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05223","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in C/D snoRNP assembly; regulates abundance of Rsa1p; required for growth at high temperature; similar to human ZNHIT3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003816","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR055W"}


id: YJR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000003817","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR056C"}


id: YJR057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04657":null,"YJR057W":null},"has_protein_features":false,"name":"CDC8","ortholog_annotations":[{"gene_uniquename":"YJR057W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04657","reference_uniquename":"PMID:29761456"}],"product":"Nucleoside monophosphate and nucleoside diphosphate kinase; functions in the de novo biosynthesis of pyrimidine deoxyribonucleotides; thymidylate/uridylate kinase that converts nucleoside monophosphates, dTMP and dUMP to nucleoside diphosphates, dTDP and dUDP; nucleoside diphosphate kinase that converts nucleoside diphosphates, dTDP and dUDP to dTTP and dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe tmp1; human homolog DTYMK can complement the cdc8 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003818","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR057W"}


id: YJR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02805":null,"YJR058C":null},"has_protein_features":false,"name":"APS2","ortholog_annotations":[{"gene_uniquename":"YJR058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02805","reference_uniquename":"PMID:29761456"}],"product":"Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003819","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR058C"}


id: YJR059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04469":null,"YJR059W":null},"has_protein_features":false,"name":"PTK2","ortholog_annotations":[{"gene_uniquename":"YJR059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04469","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase; involved in regulation of ion transport across plasma membrane; carboxyl terminus is essential for glucose-dependent Pma1p activation via phosphorylation of Pma1p-Ser899; enhances spermine uptake; PTK2 has a paralog, PTK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003820","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR059W"}


id: YJR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01343":null,"YJR060W":null},"has_protein_features":false,"name":"CBF1","ortholog_annotations":[{"gene_uniquename":"YJR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01343","reference_uniquename":"PMID:29761456"}],"product":"Basic helix-loop-helix (bHLH) protein; forms homodimer to bind E-box consensus sequence CACGTG present at MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins, required for chromosome segregation; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003821","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR060W"}


id: YJR061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MNN14","product":"Protein required for N-glycan mannosylphosphorylation; non-essential gene; transcription repressed by Rm101p; MNN14 has a paralog, MNN4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003822","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR061W"}


id: YJR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00476":null,"YJR062C":null},"has_protein_features":false,"name":"NTA1","ortholog_annotations":[{"gene_uniquename":"YJR062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00476","reference_uniquename":"PMID:29761456"}],"product":"Amidase; removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003823","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR062C"}


id: YJR063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04106":null,"YJR063W":null},"has_protein_features":false,"name":"RPA12","ortholog_annotations":[{"gene_uniquename":"YJR063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04106","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003824","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR063W"}


id: YJR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03320":null,"YJR064W":null},"has_protein_features":false,"name":"CCT5","ortholog_annotations":[{"gene_uniquename":"YJR064W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03320","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003825","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR064W"}


id: YJR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01268":null,"YJR065C":null},"has_protein_features":false,"name":"ARP3","ortholog_annotations":[{"gene_uniquename":"YJR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01268","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003826","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR065C"}


id: YJR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02723":null,"SJAG_03067":null,"YJR066W":null},"has_protein_features":false,"name":"TOR1","ortholog_annotations":[{"gene_uniquename":"YJR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02723","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03067","reference_uniquename":"PMID:29761456"}],"product":"PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; indole-3-acetic acid, an ATP-competitive inhibitor of TORC1, accumulates upon entry into stationary phase; TOR1 has a paralog, TOR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003827","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR066W"}


id: YJR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03913":null,"YJR067C":null},"has_protein_features":false,"name":"YAE1","ortholog_annotations":[{"gene_uniquename":"YJR067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03913","reference_uniquename":"PMID:29761456"}],"product":"Substrate-specific adaptor protein involved in apo-Rli1p maturation; subunit of the Yae1-Lto1 complex, recruiting apo-Rli1p to the CIA targeting complex, facilitating the insertion of an Fe/S cluster by the Fe-S biosynthetic machinery; deca-GX3 motif crucial for complex formation; essential for aerobic but not anaerobic growth; homolog of human YAE1D1, which is overexpressed in oral cancers; co-expression of YAE1D1 and LTO1 homolog ORAOV1 restores growth and Rli1p maturation after YAE1 depletion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003828","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR067C"}


id: YJR068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01010":null,"YJR068W":null},"has_protein_features":false,"name":"RFC2","ortholog_annotations":[{"gene_uniquename":"YJR068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01010","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003829","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR068W"}


id: YJR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03797":null,"YJR069C":null},"has_protein_features":false,"name":"HAM1","ortholog_annotations":[{"gene_uniquename":"YJR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03797","reference_uniquename":"PMID:29761456"}],"product":"Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003830","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR069C"}


id: YJR070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02285":null,"YJR070C":null},"has_protein_features":false,"name":"LIA1","ortholog_annotations":[{"gene_uniquename":"YJR070C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02285","reference_uniquename":"PMID:29761456"}],"product":"Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003831","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR070C"}


id: YJR071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003832","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR071W"}


id: YJR072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04531":null,"YJR072C":null},"has_protein_features":false,"name":"NPA3","ortholog_annotations":[{"gene_uniquename":"YJR072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04531","reference_uniquename":"PMID:29761456"}],"product":"Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003833","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR072C"}


id: YJR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00812":null,"YJR073C":null},"has_protein_features":false,"name":"OPI3","ortholog_annotations":[{"gene_uniquename":"YJR073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00812","reference_uniquename":"PMID:29761456"}],"product":"Methylene-fatty-acyl-phospholipid synthase; catalyzes the last two steps in phosphatidylcholine biosynthesis; also known as phospholipid methyltransferase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003834","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR073C"}


id: YJR074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03002":null,"YJR074W":null},"has_protein_features":false,"name":"MOG1","ortholog_annotations":[{"gene_uniquename":"YJR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03002","reference_uniquename":"PMID:29761456"}],"product":"Conserved nuclear protein that interacts with GTP-Gsp1p; stimulates nucleotide release from Gsp1p; involved in nuclear protein import; nucleotide release is inhibited by Yrb1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003835","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR074W"}


id: YJR075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04770":null,"YJR075W":null},"has_protein_features":false,"name":"HOC1","ortholog_annotations":[{"gene_uniquename":"YJR075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04770","reference_uniquename":"PMID:29761456"}],"product":"Alpha-1,6-mannosyltransferase; involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003836","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR075W"}


id: YJR076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04375":null,"SJAG_04470":null,"YJR076C":null},"has_protein_features":false,"name":"CDC11","ortholog_annotations":[{"gene_uniquename":"YJR076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04375","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04470","reference_uniquename":"PMID:26896847"}],"product":"Component of the septin ring that is required for cytokinesis; present at the ends of rod-like septin hetero-oligomers; C-terminal extension is important for recruitment of Bni5p to the mother-bud neck, which in turn is required for Myo1p recruitment and cytokinesis; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003837","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR076C"}


id: YJR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00547":null,"YJR077C":null},"has_protein_features":false,"name":"MIR1","ortholog_annotations":[{"gene_uniquename":"YJR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00547","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial phosphate carrier; imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003838","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR077C"}


id: YJR078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BNA2","product":"Tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase; required for de novo biosynthesis of NAD+ from tryptophan via kynurenine; up-regulated by telomere uncapping, and interacts genetically with capping gene CDC13; overexpression reduces lipid droplet accumulation by skewing glycolytic flux towards biosynthesis of shikimate, aromatic amino acids, and NAD+ during aging and extends lifespan; regulated by Hst1p and Aftp","secondary_identifier":"SGD:S000003839","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR078W"}


id: YJR079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; mutation results in impaired mitochondrial respiration","secondary_identifier":"SGD:S000003840","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR079W"}


id: YJR080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AIM24","product":"Protein with a role in determining mitochondrial architecture; inner membrane protein that interacts physically and genetically with the MICOS complex and is required for its integrity","secondary_identifier":"SGD:S000003841","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR080C"}


id: YJR082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01385":null,"YJR082C":null},"has_protein_features":false,"name":"EAF6","ortholog_annotations":[{"gene_uniquename":"YJR082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01385","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the NuA4 acetyltransferase complex; this complex acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003842","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR082C"}


id: YJR083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ACF4","product":"Protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate","secondary_identifier":"SGD:S000003843","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR083C"}


id: YJR084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00298":null,"SJAG_04347":null,"YJR084W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJR084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00298","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJR084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04347","reference_uniquename":"PMID:29761456"}],"product":"Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003844","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR084W"}


id: YJR085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04515":null,"YJR085C":null},"has_protein_features":false,"name":"TMH11","ortholog_annotations":[{"gene_uniquename":"YJR085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04515","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003845","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR085C"}


id: YJR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"STE18","product":"G protein gamma subunit; forms dimer with Ste4p to activate mating signaling pathway, heterotrimer with Gpa1p, Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling; N-terminal phosphorylation of Ste18p functions synergistically with Fus3p docking site on Ste5p to restrict Ste5p plasma membrane recruitment and signaling; combinatorial phosphorylation at S3 and S7, by pheromone and pH stress, modulates Ste18p structure, Fus3p activation","secondary_identifier":"SGD:S000003846","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR086W"}


id: YJR087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2","secondary_identifier":"SGD:S000003847","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR087W"}


id: YJR088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02065":null,"YJR088C":null},"has_protein_features":false,"name":"EMC2","ortholog_annotations":[{"gene_uniquename":"YJR088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02065","reference_uniquename":"PMID:29761456"}],"product":"Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003848","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR088C"}


id: YJR089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04412":null,"YJR089W":null},"has_protein_features":false,"name":"BIR1","ortholog_annotations":[{"gene_uniquename":"YJR089W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04412","reference_uniquename":"PMID:29761456"}],"product":"Subunit of chromosomal passenger complex (CPC); CPC is comprised of Ipl1p-Sli15p-Bir1p-Nbl1p and regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension; relative distribution to shortened microtubules increases upon DNA replication stress; sumoylated in an Mms21p-dependent manner; human survivin homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003849","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR089W"}


id: YJR090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00651":null,"YJR090C":null},"has_protein_features":false,"name":"GRR1","ortholog_annotations":[{"gene_uniquename":"YJR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00651","reference_uniquename":"PMID:29761456"}],"product":"F-box protein component of an SCF ubiquitin-ligase complex; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCF(Grr1) complex; SCF(Grr1) acts as a ubiquitin-protein ligase directing ubiquitination of substrates such as: Gic2p, Mks1p, Mth1p, Cln1p, Cln2p and Cln3p; involved in carbon catabolite repression, glucose-dependent divalent cation transport, glucose transport, morphogenesis, and sulfite detoxification","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003850","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR090C"}


id: YJR091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00391":null,"SJAG_16457":null,"YJR091C":null},"has_protein_features":false,"name":"JSN1","ortholog_annotations":[{"gene_uniquename":"YJR091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00391","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16457","reference_uniquename":"PMID:29761456"}],"product":"Member of the Puf family of RNA-binding proteins; interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl; JSN1 has a paralog, PUF2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003851","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR091C"}


id: YJR092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00118":null,"SJAG_01143":null,"YJR092W":null},"has_protein_features":false,"name":"BUD4","ortholog_annotations":[{"gene_uniquename":"YJR092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00118","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01143","reference_uniquename":"PMID:29761456"}],"product":"Anillin-like protein involved in bud-site selection; required for the axial budding pattern; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; functions as a platform linking the cytokinesis tag septins to the axial landmark through its multiple domains; in vivo substrate of Cdc28p/Clb2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003852","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR092W"}


id: YJR093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00961":null,"YJR093C":null},"has_protein_features":false,"name":"FIP1","ortholog_annotations":[{"gene_uniquename":"YJR093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00961","reference_uniquename":"PMID:29761456"}],"product":"Subunit of cleavage polyadenylation factor (CPF); interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003853","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR093C"}


id: YJR094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IME1","product":"Master regulator of meiosis that is active only during meiotic events; activates transcription of early meiotic genes through interaction with Ume6p; degraded by the 26S proteasome following phosphorylation by Ime2p; transcription is negatively regulated in cis by the IRT1 long noncoding antisense RNA","secondary_identifier":"SGD:S000003854","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR094C"}


id: YJR094W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02510":null,"SJAG_03043":null,"YJR094W-A":null},"has_protein_features":false,"name":"RPL43B","ortholog_annotations":[{"gene_uniquename":"YJR094W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02510","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR094W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03043","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003855","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR094W-A"}


id: YJR095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SFC1","product":"Mitochondrial succinate-fumarate transporter; transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization","secondary_identifier":"SGD:S000003856","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR095W"}


id: YJR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03958":null,"SJAG_04660":null,"YJR096W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03958","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04660","reference_uniquename":"PMID:29761456"}],"product":"Xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003857","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR096W"}


id: YJR097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00251":null,"YJR097W":null},"has_protein_features":false,"name":"JJJ3","ortholog_annotations":[{"gene_uniquename":"YJR097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00251","reference_uniquename":"PMID:29761456"}],"product":"Iron-binding protein; involved in targeting cytoplasmic SRP-independent proteins to the ER; contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003858","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR097W"}


id: YJR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000003859","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR098C"}


id: YJR099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00795":null,"YJR099W":null},"has_protein_features":false,"name":"YUH1","ortholog_annotations":[{"gene_uniquename":"YJR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00795","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin C-terminal hydrolase; cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003860","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR099W"}


id: YJR100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01470":null,"YJR100C":null},"has_protein_features":false,"name":"AIM25","ortholog_annotations":[{"gene_uniquename":"YJR100C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01470","reference_uniquename":"PMID:29761456"}],"product":"Mitochondria protein of unknown function; interacts genetically with TOR1 to regulate chronological lifespan, and the response to both heat shock and oxidative stress; involved in maintaining the integrity of the mitochondrial network; negative regulator of mitophagy flux; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant is viable and displays an elevated frequency of mitochondrial genome loss; similar to murine NOR1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003861","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR100C"}


id: YJR101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01734":null,"SJAG_04788":null,"YJR101W":null},"has_protein_features":false,"name":"RSM26","ortholog_annotations":[{"gene_uniquename":"YJR101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01734","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04788","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003862","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR101W"}


id: YJR102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04912":null,"YJR102C":null},"has_protein_features":false,"name":"VPS25","ortholog_annotations":[{"gene_uniquename":"YJR102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04912","reference_uniquename":"PMID:29761456"}],"product":"Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003863","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR102C"}


id: YJR103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05024":null,"YJR103W":null},"has_protein_features":false,"name":"URA8","ortholog_annotations":[{"gene_uniquename":"YJR103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05024","reference_uniquename":"PMID:29761456"}],"product":"Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003864","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR103W"}


id: YJR104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00668":null,"YJR104C":null},"has_protein_features":false,"name":"SOD1","ortholog_annotations":[{"gene_uniquename":"YJR104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00668","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; human ortholog SOD1 implicated in ALS complements a null allele; abundance increases under DNA replication stress and during exposure to boric acid; localization to mitochondrial intermembrane space is modulated by MICOS complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003865","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR104C"}


id: YJR105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01070":null,"YJR105W":null},"has_protein_features":false,"name":"ADO1","ortholog_annotations":[{"gene_uniquename":"YJR105W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01070","reference_uniquename":"PMID:29761456"}],"product":"Adenosine kinase; required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003866","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR105W"}


id: YJR106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04892":null,"YJR106W":null},"has_protein_features":false,"name":"ECM27","ortholog_annotations":[{"gene_uniquename":"YJR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04892","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003867","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR106W"}


id: YJR107C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; encodes new type of domain, which ab initio modeling suggests is predominantly alpha-helical; nonessential for growth, deletion increases sensitivity to osmostress; expressed at moderate to high abundance; ORF also present in strains EC1118, YJM789, RM11-1a, and AWRI1631; Gln24 in S288C reference is substituted with Arg in wine strain EC1118; predicted S-palmitoylation site on Cys2, suggesting membrane association; transcript previously mischaracterized as SUT646","secondary_identifier":"SGD:S000303810","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR107C-A"}


id: YJR107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LIH1","product":"Putative lipase","secondary_identifier":"SGD:S000003868","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR107W"}


id: YJR108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ABM1","product":"Protein of unknown function; required for normal microtubule organization","secondary_identifier":"SGD:S000003869","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR108W"}


id: YJR109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00412":null,"YJR109C":null},"has_protein_features":false,"name":"CPA2","ortholog_annotations":[{"gene_uniquename":"YJR109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00412","reference_uniquename":"PMID:29761456"}],"product":"Large subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003870","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR109C"}


id: YJR110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03248":null,"YJR110W":null},"has_protein_features":false,"name":"YMR1","ortholog_annotations":[{"gene_uniquename":"YJR110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03248","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003871","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR110W"}


id: YJR111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02630":null,"YJR111C":null},"has_protein_features":false,"name":"PXP2","ortholog_annotations":[{"gene_uniquename":"YJR111C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02630","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal matrix protein with naturally active promoter; well-conserved in fungi; localized to peroxisomes under physiological growth conditions; levels of some amino acids are altered upon both knockout and overexpression, suggesting potential involvement of Pxp2p in amino acid metabolism or related cellular metabolic processes (needs further study); GFP-fusion protein displays inherent dual localization with large proportion localizing to cytosol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003872","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR111C"}


id: YJR112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00418":null,"YJR112W":null},"has_protein_features":false,"name":"NNF1","ortholog_annotations":[{"gene_uniquename":"YJR112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00418","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the outer kinetochore MIND complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for kinetochore bi-orientation and accurate chromosome segregation; complex consists of Mtw1p, Nnf1p, Nsl1p and Dsn1p; homologous to metazoan CENP-H proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003873","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR112W"}


id: YJR112W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00215":null,"YJR112W-A":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJR112W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00215","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; identified based on homology to <i>Ashbya gossypii</i>","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028513","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR112W-A"}


id: YJR113C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00513":null,"YJR113C":null},"has_protein_features":false,"name":"RSM7","ortholog_annotations":[{"gene_uniquename":"YJR113C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00513","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S7 ribosomal protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003874","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR113C"}


id: YJR114W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C","secondary_identifier":"SGD:S000003875","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR114W"}


id: YJR115W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003876","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR115W"}


id: YJR116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01912":null,"YJR116W":null},"has_protein_features":false,"name":"TDA4","ortholog_annotations":[{"gene_uniquename":"YJR116W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01912","reference_uniquename":"PMID:29761456"}],"product":"Protein distantly similar to ceramide synthases, Lag1p and Lac1p; null mutant is sensitive to expression of the top1-T722A allele; mutation confers sensitivity to copper","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003877","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR116W"}


id: YJR117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03396":null,"YJR117W":null},"has_protein_features":false,"name":"STE24","ortholog_annotations":[{"gene_uniquename":"YJR117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03396","reference_uniquename":"PMID:29761456"}],"product":"Highly conserved zinc metalloprotease; component of the ER quality control mechanism that removes faulty proteins clogging translocation channels; inhibits SRP-independent translocation into the ER; has two roles in a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; cleaves isoprenylated and non-prenylated oligopeptides; human homolog ZMPSTE24 implicated in mandibuloacral dysplasia (MAD), and complements the null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003878","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR117W"}


id: YJR118C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00127":null,"YJR118C":null},"has_protein_features":false,"name":"ILM1","ortholog_annotations":[{"gene_uniquename":"YJR118C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00127","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003879","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR118C"}


id: YJR119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03286":null,"YJR119C":null},"has_protein_features":false,"name":"JHD2","ortholog_annotations":[{"gene_uniquename":"YJR119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03286","reference_uniquename":"PMID:29761456"}],"product":"JmjC domain family histone demethylase; promotes global demethylation of H3K4 and repression of noncoding intergenic transcription during sporulation; removes methyl groups added by Set1p; negatively regulated by H3K14 acetylation; protein levels regulated by Not4p polyubiquitin-mediated degradation; regulates sporulation timing by extending period of active transcription; regulates rDNA silencing; human homolog is JARID1C","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003880","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR119C"}


id: YJR120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p","secondary_identifier":"SGD:S000003881","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR120W"}


id: YJR121W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02598":null,"YJR121W":null},"has_protein_features":false,"name":"ATP2","ortholog_annotations":[{"gene_uniquename":"YJR121W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02598","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003882","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR121W"}


id: YJR122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02306":null,"YJR122W":null},"has_protein_features":false,"name":"IBA57","ortholog_annotations":[{"gene_uniquename":"YJR122W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02306","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in incorporating iron-sulfur clusters into proteins; mitochondrial matrix protein; involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003883","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR122W"}


id: YJR123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00523":null,"SJAG_02477":null,"YJR123W":null},"has_protein_features":false,"name":"RPS5","ortholog_annotations":[{"gene_uniquename":"YJR123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00523","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02477","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003884","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR123W"}


id: YJR124C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; expression induced under calcium shortage","secondary_identifier":"SGD:S000003885","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR124C"}


id: YJR125C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02177":null,"YJR125C":null},"has_protein_features":false,"name":"ENT3","ortholog_annotations":[{"gene_uniquename":"YJR125C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02177","reference_uniquename":"PMID:29761456"}],"product":"Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003886","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR125C"}


id: YJR126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02117":null,"YJR126C":null},"has_protein_features":false,"name":"VPS70","ortholog_annotations":[{"gene_uniquename":"YJR126C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02117","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function involved in vacuolar protein sorting; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003887","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR126C"}


id: YJR127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RSF2","product":"Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000003888","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR127C"}


id: YJR128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; partially overlaps the verified ORF RSF2","secondary_identifier":"SGD:S000003889","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR128W"}


id: YJR129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01536":null,"YJR129C":null},"has_protein_features":false,"name":"EFM3","ortholog_annotations":[{"gene_uniquename":"YJR129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01536","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which trimethylates translation elongation factor EF2 (Eft1p and Eft2p) at lysine 509; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; ortholog of human gene FAM86A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003890","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR129C"}


id: YJR130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03102":null,"YJR130C":null},"has_protein_features":false,"name":"STR2","ortholog_annotations":[{"gene_uniquename":"YJR130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03102","reference_uniquename":"PMID:29761456"}],"product":"Cystathionine gamma-synthase, converts cysteine into cystathionine; STR2 has a paralog, YML082W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003891","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR130C"}


id: YJR131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03032":null,"YJR131W":null},"has_protein_features":false,"name":"MNS1","ortholog_annotations":[{"gene_uniquename":"YJR131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03032","reference_uniquename":"PMID:29761456"}],"product":"Alpha-1,2-mannosidase; involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003892","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR131W"}


id: YJR132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03693":null,"YJR132W":null},"has_protein_features":false,"name":"NMD5","ortholog_annotations":[{"gene_uniquename":"YJR132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03693","reference_uniquename":"PMID:29761456"}],"product":"Karyopherin; a carrier protein involved in nuclear import of proteins; importin beta homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003893","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR132W"}


id: YJR133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06634":null,"YJR133W":null},"has_protein_features":false,"name":"XPT1","ortholog_annotations":[{"gene_uniquename":"YJR133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06634","reference_uniquename":"PMID:29761456"}],"product":"Xanthine-guanine phosphoribosyl transferase; required for xanthine utilization and for optimal utilization of guanine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003894","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR133W"}


id: YJR134C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03842":null,"YJR134C":null},"has_protein_features":false,"name":"SGM1","ortholog_annotations":[{"gene_uniquename":"YJR134C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03842","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003895","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR134C"}


id: YJR135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04177":null,"YJR135C":null},"has_protein_features":false,"name":"MCM22","ortholog_annotations":[{"gene_uniquename":"YJR135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04177","reference_uniquename":"PMID:29761456"}],"product":"Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003896","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR135C"}


id: YJR135W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02524":null,"YJR135W-A":null},"has_protein_features":false,"name":"TIM8","ortholog_annotations":[{"gene_uniquename":"YJR135W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02524","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial intermembrane space protein; forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome, also known as deafness-dystonia-optic neuronopathy (DDON) syndrome; human TIMM8A can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007348","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR135W-A"}


id: YJR136C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05206":null,"YJR136C":null},"has_protein_features":false,"name":"TTI2","ortholog_annotations":[{"gene_uniquename":"YJR136C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05206","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; involved in the cellular stress response; similar to S. pombe Tti2p; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003897","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR136C"}


id: YJR137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05027":null,"YJR137C":null},"has_protein_features":false,"name":"MET5","ortholog_annotations":[{"gene_uniquename":"YJR137C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05027","reference_uniquename":"PMID:29761456"}],"product":"Sulfite reductase beta subunit; involved in amino acid biosynthesis, transcription repressed by methionine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003898","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR137C"}


id: YJR138W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00824":null,"YJR138W":null},"has_protein_features":false,"name":"IML1","ortholog_annotations":[{"gene_uniquename":"YJR138W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00824","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of the SEA complex, a coatomer-related complex that associates dynamically with the vacuole; Iml1p functions in the SEACIT complex as a GAP for the Rag family GTPase Gtr1p (EGOC subunit), resulting in the inhibition of TORC1 signaling in response to amino acid deprivation; the Iml1p/SEACIT complex is required for non-nitrogen-starvation (NNS)-induced autophagy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003899","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR138W"}


id: YJR139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03152":null,"YJR139C":null},"has_protein_features":false,"name":"HOM6","ortholog_annotations":[{"gene_uniquename":"YJR139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03152","reference_uniquename":"PMID:29761456"}],"product":"Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase); dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003900","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR139C"}


id: YJR140C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00914":null,"YJR140C":null},"has_protein_features":false,"name":"HIR3","ortholog_annotations":[{"gene_uniquename":"YJR140C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00914","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003901","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR140C"}


id: YJR140W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene HIR3; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028666","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR140W-A"}


id: YJR141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00435":null,"YJR141W":null},"has_protein_features":false,"name":"IPA1","ortholog_annotations":[{"gene_uniquename":"YJR141W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00435","reference_uniquename":"PMID:29761456"}],"product":"Protein implicated in pre-mRNA processing and proteasomal degradation; interacts physically and genetically with mRNA cleavage and polyadenylation factors; mutant is impaired in pre-mRNA cleavage and polyadenylation; associates with several Ub-conjugating enzymes and alters Ub-mediated proteasome activity; localizes to both the nucleus and cytosol; contains a HECT_2 domain; homologous to human ubiquitin-protein ligase, UBE3D, a gene implicated in age-related macular degeneration","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003902","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR141W"}


id: YJR142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03362":null,"YJR142W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJR142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03362","reference_uniquename":"PMID:29761456"}],"product":"8-oxo-dGTP diphosphatase of the Nudix hydrolase family; converts diphosphates of damaged forms of thiamin to monophosphates; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003903","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR142W"}


id: YJR143C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01491":null,"YJR143C":null},"has_protein_features":false,"name":"PMT4","ortholog_annotations":[{"gene_uniquename":"YJR143C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01491","reference_uniquename":"PMID:29761456"}],"product":"Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003904","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR143C"}


id: YJR144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03068":null,"YJR144W":null},"has_protein_features":false,"name":"MGM101","ortholog_annotations":[{"gene_uniquename":"YJR144W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03068","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in mitochondrial DNA recombinational repair; also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage and mitochondrial genome maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003905","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR144W"}


id: YJR145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04324":null,"SJAG_04663":null,"YJR145C":null},"has_protein_features":false,"name":"RPS4A","ortholog_annotations":[{"gene_uniquename":"YJR145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04324","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04663","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003906","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR145C"}


id: YJR146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2","secondary_identifier":"SGD:S000003907","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR146W"}


id: YJR147W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HMS2","product":"Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003908","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR147W"}


id: YJR148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04149":null,"YJR148W":null},"has_protein_features":false,"name":"BAT2","ortholog_annotations":[{"gene_uniquename":"YJR148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04149","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase; BAT2 has a paralog, BAT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003909","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR148W"}


id: YJR149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000003910","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR149W"}


id: YJR150C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DAN1","product":"Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth","secondary_identifier":"SGD:S000003911","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR150C"}


id: YJR151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DAN4","product":"Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth","secondary_identifier":"SGD:S000003912","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR151C"}


id: YJR151W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational 'guilt by association' analysis","secondary_identifier":"SGD:S000028557","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR151W-A"}


id: YJR152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02139":null,"SJAG_05182":null,"YJR152W":null},"has_protein_features":false,"name":"DAL5","ortholog_annotations":[{"gene_uniquename":"YJR152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02139","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05182","reference_uniquename":"PMID:29761456"}],"product":"Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003913","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR152W"}


id: YJR153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PGU1","product":"Endo-polygalacturonase; pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins","secondary_identifier":"SGD:S000003914","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR153W"}


id: YJR154W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000003915","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR154W"}


id: YJR155W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AAD10","product":"Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family","secondary_identifier":"SGD:S000003916","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR155W"}


id: YJR156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04866":null,"YJR156C":null},"has_protein_features":false,"name":"THI11","ortholog_annotations":[{"gene_uniquename":"YJR156C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04866","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003917","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR156C"}


id: YJR157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003918","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR157W"}


id: YJR158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YJR158W":null},"has_protein_features":false,"name":"HXT16","ortholog_annotations":[{"gene_uniquename":"YJR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003919","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR158W"}


id: YJR159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00237":null,"YJR159W":null},"has_protein_features":false,"name":"SOR1","ortholog_annotations":[{"gene_uniquename":"YJR159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00237","reference_uniquename":"PMID:29761456"}],"product":"Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor2p sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003920","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR159W"}


id: YJR160C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MPH3","product":"Alpha-glucoside permease; transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication","secondary_identifier":"SGD:S000003921","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR160C"}


id: YJR161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COS5","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000003922","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR161C"}


id: YJR162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003923","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR162C"}


id: YKL001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00084":null,"YKL001C":null},"has_protein_features":false,"name":"MET14","ortholog_annotations":[{"gene_uniquename":"YKL001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00084","reference_uniquename":"PMID:29761456"}],"product":"Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001484","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL001C"}


id: YKL002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04489":null,"YKL002W":null},"has_protein_features":false,"name":"DID4","ortholog_annotations":[{"gene_uniquename":"YKL002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04489","reference_uniquename":"PMID:29761456"}],"product":"Class E Vps protein of the ESCRT-III complex; required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001485","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL002W"}


id: YKL003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01468":null,"YKL003C":null},"has_protein_features":false,"name":"MRP17","ortholog_annotations":[{"gene_uniquename":"YKL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01468","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001486","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL003C"}


id: YKL003W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Deleted ORF; does not encode a discrete protein; YKL003W-A was added based on homology to closely related fungi, but was later withdrawn because it was completely contained within DID4/YKL002W","secondary_identifier":"SGD:S000007614","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL003W-A"}


id: YKL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00506":null,"YKL004W":null},"has_protein_features":false,"name":"AUR1","ortholog_annotations":[{"gene_uniquename":"YKL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00506","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol:ceramide phosphoinositol transferase; required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance; also known as IPC synthase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001487","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL004W"}


id: YKL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01707":null,"YKL005C":null},"has_protein_features":false,"name":"BYE1","ortholog_annotations":[{"gene_uniquename":"YKL005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01707","reference_uniquename":"PMID:29761456"}],"product":"Negative regulator of transcription elongation; contains a TFIIS-like domain that associates with chromatin and a PHD domain that interacts with H3K4me3; multicopy suppressor of temperature-sensitive ess1 mutations, binds RNA polymerase II large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001488","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL005C"}


id: YKL006C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00804":null,"YKL006C-A":null},"has_protein_features":false,"name":"SFT1","ortholog_annotations":[{"gene_uniquename":"YKL006C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00804","reference_uniquename":"PMID:29761456"}],"product":"Intra-Golgi v-SNARE; required for transport of proteins between an early and a later Golgi compartment","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002101","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL006C-A"}


id: YKL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01364":null,"SJAG_02890":null,"YKL006W":null},"has_protein_features":false,"name":"RPL14A","ortholog_annotations":[{"gene_uniquename":"YKL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01364","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02890","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001489","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL006W"}


id: YKL007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01894":null,"YKL007W":null},"has_protein_features":false,"name":"CAP1","ortholog_annotations":[{"gene_uniquename":"YKL007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01894","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001490","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL007W"}


id: YKL008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02085":null,"SJAG_02842":null,"YKL008C":null},"has_protein_features":false,"name":"LAC1","ortholog_annotations":[{"gene_uniquename":"YKL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02085","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02842","reference_uniquename":"PMID:29761456"}],"product":"Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p; LAC1 has a paralog, LAG1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001491","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL008C"}


id: YKL009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03466":null,"YKL009W":null},"has_protein_features":false,"name":"MRT4","ortholog_annotations":[{"gene_uniquename":"YKL009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03466","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in mRNA turnover and ribosome assembly; required at post-transcriptional step for efficient retrotransposition; localizes to the nucleolus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001492","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL009W"}


id: YKL010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01900":null,"YKL010C":null},"has_protein_features":false,"name":"UFD4","ortholog_annotations":[{"gene_uniquename":"YKL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01900","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; involved in K29-linked ubiquitin-dependent protein catabolism, including ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001493","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL010C"}


id: YKL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04752":null,"YKL011C":null},"has_protein_features":false,"name":"CCE1","ortholog_annotations":[{"gene_uniquename":"YKL011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04752","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial cruciform cutting endonuclease; cleaves Holliday junctions formed during recombination of mitochondrial DNA; CCE1 has a paralog, MRS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001494","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL011C"}


id: YKL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01654":null,"YKL012W":null},"has_protein_features":false,"name":"PRP40","ortholog_annotations":[{"gene_uniquename":"YKL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01654","reference_uniquename":"PMID:29761456"}],"product":"U1 snRNP protein involved in splicing; interacts with the branchpoint-binding protein during the formation of the second commitment complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001495","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL012W"}


id: YKL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02245":null,"YKL013C":null},"has_protein_features":false,"name":"ARC19","ortholog_annotations":[{"gene_uniquename":"YKL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02245","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; mutation is functionally complemented by human ARPC4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001496","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL013C"}


id: YKL014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04289":null,"YKL014C":null},"has_protein_features":false,"name":"URB1","ortholog_annotations":[{"gene_uniquename":"YKL014C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04289","reference_uniquename":"PMID:29761456"}],"product":"Protein required for the normal accumulation of 25S and 5.8S rRNAs; nucleolar protein; associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001497","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL014C"}


id: YKL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02709":null,"YKL015W":null},"has_protein_features":false,"name":"PUT3","ortholog_annotations":[{"gene_uniquename":"YKL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02709","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional activator; binds specific gene recruitment sequences and is required for DNA zip code-mediated targeting of genes to nuclear periphery; regulates proline utilization genes, constitutively binds PUT1 and PUT2 promoters as a dimer, undergoes conformational change to form active state; binds other promoters only under activating conditions; differentially phosphorylated in presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001498","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL015W"}


id: YKL016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03925":null,"YKL016C":null},"has_protein_features":false,"name":"ATP7","ortholog_annotations":[{"gene_uniquename":"YKL016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03925","reference_uniquename":"PMID:29761456"}],"product":"Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001499","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL016C"}


id: YKL017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03495":null,"YKL017C":null},"has_protein_features":false,"name":"HCS1","ortholog_annotations":[{"gene_uniquename":"YKL017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03495","reference_uniquename":"PMID:29761456"}],"product":"Hexameric DNA polymerase alpha-associated DNA helicase A; involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001500","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL017C"}


id: YKL018C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MCO12","product":"Putative mitochondrial protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000007615","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL018C-A"}


id: YKL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01599":null,"SJAG_03431":null,"YKL018W":null},"has_protein_features":false,"name":"SWD2","ortholog_annotations":[{"gene_uniquename":"YKL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01599","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03431","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex; required for Set1C stability and optimal activity; COMPASS methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001501","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL018W"}


id: YKL019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04923":null,"YKL019W":null},"has_protein_features":false,"name":"RAM2","ortholog_annotations":[{"gene_uniquename":"YKL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04923","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I; farnesyltransferase (Ram2p-Ram1p heterodimer) catalyzes the addition of 15-carbon isoprenoid farnesyl to substrate proteins containing a CAAX consensus motif; type I geranylgeranyltransferase (Ram2p-Cdc43p heterodimer) catalyzes the addition of the 20-carbon isoprenoid geranylgeranyl to substrate proteins containing a CaaL consensus motif; required for membrane localization of Ras proteins and a-factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001502","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL019W"}


id: YKL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02196":null,"YKL020C":null},"has_protein_features":false,"name":"SPT23","ortholog_annotations":[{"gene_uniquename":"YKL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02196","reference_uniquename":"PMID:29761456"}],"product":"ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; SPT23 has a paralog, MGA2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001503","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL020C"}


id: YKL021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01821":null,"YKL021C":null},"has_protein_features":false,"name":"MAK11","ortholog_annotations":[{"gene_uniquename":"YKL021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01821","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in an early step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001504","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL021C"}


id: YKL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03350":null,"YKL022C":null},"has_protein_features":false,"name":"CDC16","ortholog_annotations":[{"gene_uniquename":"YKL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03350","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the anaphase-promoting complex/cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001505","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL022C"}


id: YKL023C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MIN9","product":"Mitochondrial protein of unknown function","secondary_identifier":"SGD:S000113559","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL023C-A"}


id: YKL023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SKA1","product":"SKI complex-associated protein; involved in 3'-5' degradation of long 3'UTR-containing mRNA, poorly translated mRNA, and other RNA regions devoid of ribosomes; proposed to assist the cytoplasmic exosome in a Ska1-SKI complex when a direct interaction between the ribosome and the SKI complex is absent","secondary_identifier":"SGD:S000001506","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL023W"}


id: YKL024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00779":null,"YKL024C":null},"has_protein_features":false,"name":"URA6","ortholog_annotations":[{"gene_uniquename":"YKL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00779","reference_uniquename":"PMID:29761456"}],"product":"Uridylate kinase; catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001507","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL024C"}


id: YKL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01910":null,"SJAG_02808":null,"YKL025C":null},"has_protein_features":false,"name":"PAN3","ortholog_annotations":[{"gene_uniquename":"YKL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01910","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02808","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; poly (A) mRNA binding subunit which recruits mRNA to the complex; the Pan2p-Pan3p complex controls poly(A) tail length and regulates the stoichiometry and activity of postreplication repair complexes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001508","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL025C"}


id: YKL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01216":null,"YKL026C":null},"has_protein_features":false,"name":"GPX1","ortholog_annotations":[{"gene_uniquename":"YKL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01216","reference_uniquename":"PMID:29761456"}],"product":"Phospholipid hydroperoxide glutathione peroxidase; induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; glutathione peroxidase activity is neuroprotective in models of Huntington's disease; GPX1 has a paralog, HYR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001509","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL026C"}


id: YKL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02084":null,"YKL027W":null},"has_protein_features":false,"name":"TCD2","ortholog_annotations":[{"gene_uniquename":"YKL027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02084","reference_uniquename":"PMID:29761456"}],"product":"tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD2 has a paralog, TCD1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001510","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL027W"}


id: YKL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00116":null,"YKL028W":null},"has_protein_features":false,"name":"TFA1","ortholog_annotations":[{"gene_uniquename":"YKL028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00116","reference_uniquename":"PMID:29761456"}],"product":"TFIIE large subunit; involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001511","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL028W"}


id: YKL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02176":null,"YKL029C":null},"has_protein_features":false,"name":"MAE1","ortholog_annotations":[{"gene_uniquename":"YKL029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02176","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001512","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL029C"}


id: YKL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1","secondary_identifier":"SGD:S000001513","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL030W"}


id: YKL031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species","secondary_identifier":"SGD:S000001514","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL031W"}


id: YKL032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00634":null,"YKL032C":null},"has_protein_features":false,"name":"IXR1","ortholog_annotations":[{"gene_uniquename":"YKL032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00634","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional repressor that regulates hypoxic genes during normoxia; involved in the aerobic repression of genes such as COX5b, TIR1, and HEM13; binds DNA intrastrand cross-links formed by cisplatin; HMG (high mobility group box) domain containing protein which binds and bends cisplatin-modified DNA, blocking excision repair; IXR1 has a paralog, ABF2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001515","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL032C"}


id: YKL033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03267":null,"YKL033W":null},"has_protein_features":false,"name":"TTI1","ortholog_annotations":[{"gene_uniquename":"YKL033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03267","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001516","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL033W"}


id: YKL033W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04264":null,"SJAG_05029":null,"YKL033W-A":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YKL033W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04264","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL033W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05029","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; similar to uncharacterized proteins from other fungi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL033W-A"}


id: YKL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04151":null,"YKL034W":null},"has_protein_features":false,"name":"TUL1","ortholog_annotations":[{"gene_uniquename":"YKL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04151","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001517","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL034W"}


id: YKL035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01089":null,"SJAG_02178":null,"YKL035W":null},"has_protein_features":false,"name":"UGP1","ortholog_annotations":[{"gene_uniquename":"YKL035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01089","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02178","reference_uniquename":"PMID:29761456"}],"product":"UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; involved in PKA-mediated oxidative stress resistance and long-term survival in stationary phase; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001518","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL035W"}


id: YKL036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W","secondary_identifier":"SGD:S000001519","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL036C"}


id: YKL037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AIM26","product":"Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT","secondary_identifier":"SGD:S000001520","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL037W"}


id: YKL038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01930":null,"YKL038W":null},"has_protein_features":false,"name":"RGT1","ortholog_annotations":[{"gene_uniquename":"YKL038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01930","reference_uniquename":"PMID:29761456"}],"product":"Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; recruits Tup1p/Cyc8p to target gene promoters; RGT1 has a paralog, EDS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL038W"}


id: YKL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02193":null,"SJAG_02823":null,"YKL039W":null},"has_protein_features":false,"name":"PTM1","ortholog_annotations":[{"gene_uniquename":"YKL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02193","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02823","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL039W"}


id: YKL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03222":null,"YKL040C":null},"has_protein_features":false,"name":"NFU1","ortholog_annotations":[{"gene_uniquename":"YKL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03222","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress; acts along with Bol3 at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to client proteins; Fe-S loaded homodimer at steady state; similar to NifU, a bacterial protein required for Fe/S cluster maturation; ortholog of the human NFU1, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS1)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL040C"}


id: YKL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03783":null,"YKL041W":null},"has_protein_features":false,"name":"VPS24","ortholog_annotations":[{"gene_uniquename":"YKL041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03783","reference_uniquename":"PMID:29761456"}],"product":"One of four subunits of the ESCRT-III complex; forms an endosomal sorting complex required for transport III (ESCRT-III) subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001524","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL041W"}


id: YKL042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPC42","product":"Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane","secondary_identifier":"SGD:S000001525","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL042W"}


id: YKL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PHD1","product":"Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL043W"}


id: YKL044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MMO1","product":"Protein of unknown function; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the mitochondria; mRNA identified as translated by ribosome profiling data; MMO1 is a non-essential gene","secondary_identifier":"SGD:S000001527","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL044W"}


id: YKL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02627":null,"YKL045W":null},"has_protein_features":false,"name":"PRI2","ortholog_annotations":[{"gene_uniquename":"YKL045W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02627","reference_uniquename":"PMID:29761456"}],"product":"Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001528","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL045W"}


id: YKL046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00310":null,"SJAG_04850":null,"SJAG_04851":null,"SJAG_05272":null,"YKL046C":null},"has_protein_features":false,"name":"DCW1","ortholog_annotations":[{"gene_uniquename":"YKL046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00310","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YKL046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04850","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YKL046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04851","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YKL046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05272","reference_uniquename":"PMID:29761456"}],"product":"Putative mannosidase; GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001529","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL046C"}


id: YKL047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04532":null,"YKL047W":null},"has_protein_features":false,"name":"ANR2","ortholog_annotations":[{"gene_uniquename":"YKL047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04532","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; may have a role in lipid metabolism, based on localization to lipid droplets; predicted to be palmitoylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001530","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL047W"}


id: YKL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ELM1","product":"Serine/threonine protein kinase; regulates the orientation checkpoint, the morphogenesis checkpoint and the metabolic switch from fermentative to oxidative metabolism by phosphorylating the activation loop of Kin4p, Hsl1p and Snf1p respectively; cooperates with Hsl7p in recruiting Hsl1p to the septin ring, a prerequisite for subsequent recruitment, phosphorylation, and degradation of Swe1p; forms part of the bud neck ring; regulates cytokinesis","secondary_identifier":"SGD:S000001531","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL048C"}


id: YKL049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00307":null,"YKL049C":null},"has_protein_features":false,"name":"CSE4","ortholog_annotations":[{"gene_uniquename":"YKL049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00307","reference_uniquename":"PMID:29761456"}],"product":"Centromeric histone H3-like protein; associates with promoters, accessible chromatin, and RNAPII-bound regions; Cse4p associates with centromeres, promoting kinetochore assembly and Sgo1p association with centromeric chromatin; Ipl1p-dependent phosphorylation destabilizes defective kinetochores promoting bi-orientation; phosphorylation by Cdc7p maintains Cse4p at kinetochores and promotes faithful chromosome segregation; regulated by multiple E3 ligases; complements human homolog CENPA mutations","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001532","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL049C"}


id: YKL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04227":null,"YKL050C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YKL050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04227","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p; YKL050C has a paralog, EIS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001533","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL050C"}


id: YKL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04225":null,"YKL051W":null},"has_protein_features":false,"name":"SFK1","ortholog_annotations":[{"gene_uniquename":"YKL051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04225","reference_uniquename":"PMID:29761456"}],"product":"Protein that regulates phospholipid asymmetry at plasma membrane; may act to generate normal levels of PI4P; may act together with or upstream of Stt4p; at least partially mediates proper localization of Stt4p to the plasma membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001534","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL051W"}


id: YKL052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00918":null,"YKL052C":null},"has_protein_features":false,"name":"ASK1","ortholog_annotations":[{"gene_uniquename":"YKL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00918","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; sumoylated in an Mms21p-dependent manner; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001535","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL052C"}


id: YKL053C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06440":null,"YKL053C-A":null},"has_protein_features":false,"name":"MDM35","ortholog_annotations":[{"gene_uniquename":"YKL053C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06440","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial intermembrane space protein; forms complex with Ups2p that transfers phosphatidylserine from outer membrane to inner membrane for phosphatidylethanolamine synthesis; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL053C-A"}


id: YKL053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1","secondary_identifier":"SGD:S000001536","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL053W"}


id: YKL054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02116":null,"YKL054C":null},"has_protein_features":false,"name":"DEF1","ortholog_annotations":[{"gene_uniquename":"YKL054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02116","reference_uniquename":"PMID:29761456"}],"product":"RNAPII degradation factor; forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; interacts with general transcription factor TFIIH; mutant is deficient in Zip1p loading onto chromosomes during meiosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001537","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL054C"}


id: YKL055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03198":null,"YKL055C":null},"has_protein_features":false,"name":"OAR1","ortholog_annotations":[{"gene_uniquename":"YKL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03198","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase; may comprise a type II mitochondrial fatty acid synthase along with Mct1p; human homolog CBR4 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001538","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL055C"}


id: YKL056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02786":null,"YKL056C":null},"has_protein_features":false,"name":"TMA19","ortholog_annotations":[{"gene_uniquename":"YKL056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02786","reference_uniquename":"PMID:29761456"}],"product":"Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress; homolog of human TPT1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001539","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL056C"}


id: YKL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04017":null,"YKL057C":null},"has_protein_features":false,"name":"NUP120","ortholog_annotations":[{"gene_uniquename":"YKL057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04017","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001540","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL057C"}


id: YKL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02174":null,"YKL058W":null},"has_protein_features":false,"name":"TOA2","ortholog_annotations":[{"gene_uniquename":"YKL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02174","reference_uniquename":"PMID:29761456"}],"product":"TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa1p, for ribosomal protein gene transcription in vivo; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001541","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL058W"}


id: YKL059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02668":null,"YKL059C":null},"has_protein_features":false,"name":"MPE1","ortholog_annotations":[{"gene_uniquename":"YKL059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02668","reference_uniquename":"PMID:29761456"}],"product":"Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase; involved in 3' end formation of mRNA via cleavage and polyadenylation of pre-mRNA; binds pre-mRNA via the zinc knuckle and RING finger; E3 ubiquitin ligase involved in polyubiquitination of the endonuclease Ysh1p; contains a ubiquitin-like (UBL) domain, a RNA-binding zinc knuckle motif and a RING finger domain; possible role in ubiquitination of Pap1p; relocalizes to the cytosol in response to hypoxia; homolog of human RBBP6","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001542","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL059C"}


id: YKL060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01310":null,"SJAG_03373":null,"YKL060C":null},"has_protein_features":false,"name":"FBA1","ortholog_annotations":[{"gene_uniquename":"YKL060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01310","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03373","reference_uniquename":"PMID:29761456"}],"product":"Fructose 1,6-bisphosphate aldolase; required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress; N-terminally propionylated in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001543","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL060C"}


id: YKL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BLI1","product":"Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; green fluorescent protein (GFP)-fusion protein localizes to the endosome","secondary_identifier":"SGD:S000001544","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL061W"}


id: YKL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03388":null,"YKL062W":null},"has_protein_features":false,"name":"MSN4","ortholog_annotations":[{"gene_uniquename":"YKL062W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03388","reference_uniquename":"PMID:29761456"}],"product":"Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes, inducing gene expression; involved in diauxic shift","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001545","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL062W"}


id: YKL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi","secondary_identifier":"SGD:S000001546","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL063C"}


id: YKL064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02578":null,"YKL064W":null},"has_protein_features":false,"name":"MNR2","ortholog_annotations":[{"gene_uniquename":"YKL064W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02578","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001547","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL064W"}


id: YKL065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03244":null,"YKL065C":null},"has_protein_features":false,"name":"YET1","ortholog_annotations":[{"gene_uniquename":"YKL065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03244","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein; YET1 has a paralog, YET2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001548","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL065C"}


id: YKL065W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DPC7","product":"Protein of unknown function; SWAT-GFP fusion protein localizes to endoplasmic reticulum (ER) while mCherry fusion localizes to both ER and vacuole","secondary_identifier":"SGD:S000113563","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL065W-A"}


id: YKL066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1","secondary_identifier":"SGD:S000001549","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL066W"}


id: YKL067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02887":null,"YKL067W":null},"has_protein_features":false,"name":"YNK1","ortholog_annotations":[{"gene_uniquename":"YKL067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02887","reference_uniquename":"PMID:29761456"}],"product":"Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001550","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL067W"}


id: YKL068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03299":null,"YKL068W":null},"has_protein_features":false,"name":"NUP100","ortholog_annotations":[{"gene_uniquename":"YKL068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03299","reference_uniquename":"PMID:26896847"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier and is involved in gene tethering at the nuclear periphery; NUP100 has a paralog, NUP116, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001551","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL068W"}


id: YKL068W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by homology to <i>Ashbya gossypii</i>","secondary_identifier":"SGD:S000028524","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL068W-A"}


id: YKL069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000001552","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL069W"}


id: YKL070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000001553","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL070W"}


id: YKL071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OSI1","product":"NADH-dependent aldehyde reductase; involved in detoxification of furfural; expression is upregulated in cells treated with the aldehydes furfural and glycolaldehyde, the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000001554","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL071W"}


id: YKL072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"STB6","product":"Protein that binds Sin3p in a two-hybrid assay; STB6 has a paralog, STB2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001555","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL072W"}


id: YKL073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02875":null,"YKL073W":null},"has_protein_features":false,"name":"LHS1","ortholog_annotations":[{"gene_uniquename":"YKL073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02875","reference_uniquename":"PMID:29761456"}],"product":"Molecular chaperone of the endoplasmic reticulum lumen; involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001556","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL073W"}


id: YKL074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03995":null,"YKL074C":null},"has_protein_features":false,"name":"MUD2","ortholog_annotations":[{"gene_uniquename":"YKL074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03995","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001557","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL074C"}


id: YKL075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin","secondary_identifier":"SGD:S000001558","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL075C"}


id: YKL076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PSY1","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C","secondary_identifier":"SGD:S000001559","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL076C"}


id: YKL077W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00484":null,"SJAG_04419":null,"YKL077W":null},"has_protein_features":false,"name":"PSG1","ortholog_annotations":[{"gene_uniquename":"YKL077W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00484","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL077W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04419","reference_uniquename":"PMID:29761456"}],"product":"Protein that promotes the transport and maturation of Pma1 with Exp1; cleaved specifically by Kex2p; localizes to the Golgi apparatus and to the endoplasmic reticulum in HTP studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001560","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL077W"}


id: YKL078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03897":null,"YKL078W":null},"has_protein_features":false,"name":"DHR2","ortholog_annotations":[{"gene_uniquename":"YKL078W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03897","reference_uniquename":"PMID:29761456"}],"product":"Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001561","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL078W"}


id: YKL079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00332":null,"YKL079W":null},"has_protein_features":false,"name":"SMY1","ortholog_annotations":[{"gene_uniquename":"YKL079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00332","reference_uniquename":"PMID:29761456"}],"product":"Kinesin-like myosin passenger-protein; interacts with Myo2p and enhances its interaction with Sec4p during transport of secretory vesicles; controls actin cable structure and dynamics","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001562","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL079W"}


id: YKL080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01397":null,"YKL080W":null},"has_protein_features":false,"name":"VMA5","ortholog_annotations":[{"gene_uniquename":"YKL080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01397","reference_uniquename":"PMID:29761456"}],"product":"Subunit C of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001563","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL080W"}


id: YKL081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02017":null,"SJAG_03863":null,"YKL081W":null},"has_protein_features":false,"name":"TEF4","ortholog_annotations":[{"gene_uniquename":"YKL081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02017","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03863","reference_uniquename":"PMID:29761456"}],"product":"Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001564","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL081W"}


id: YKL082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02475":null,"SJAG_04562":null,"YKL082C":null},"has_protein_features":false,"name":"RRP14","ortholog_annotations":[{"gene_uniquename":"YKL082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02475","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04562","reference_uniquename":"PMID:29761456"}],"product":"Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001565","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL082C"}


id: YKL083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14","secondary_identifier":"SGD:S000001566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL083W"}


id: YKL084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01560":null,"YKL084W":null},"has_protein_features":false,"name":"HOT13","ortholog_annotations":[{"gene_uniquename":"YKL084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01560","reference_uniquename":"PMID:29761456"}],"product":"Zinc-binding mitochondrial intermembrane space (IMS) protein; involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001567","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL084W"}


id: YKL085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01753":null,"YKL085W":null},"has_protein_features":false,"name":"MDH1","ortholog_annotations":[{"gene_uniquename":"YKL085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01753","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated; mutation in human homolog MDH2 causes early-onset severe encephalopathy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001568","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL085W"}


id: YKL086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04125":null,"YKL086W":null},"has_protein_features":false,"name":"SRX1","ortholog_annotations":[{"gene_uniquename":"YKL086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04125","reference_uniquename":"PMID:29761456"}],"product":"Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001569","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL086W"}


id: YKL087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03199":null,"SJAG_04008":null,"YKL087C":null},"has_protein_features":false,"name":"CYT2","ortholog_annotations":[{"gene_uniquename":"YKL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03199","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04008","reference_uniquename":"PMID:26896847"}],"product":"Cytochrome c1 heme lyase; involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; human homolog HCCS can complement yeast cyt2 null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001570","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL087C"}


id: YKL088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CAB3","product":"Subunit of PPCDC and CoA-SPC complexes involved in CoA biosynthesis; subunits of the phosphopantothenoylcysteine decarboxylase (PPCDC) complex are: Cab3p, Sis2p, Vhs3p, while the subunits of the CoA-synthesizing protein complex (CoA-SPC) are: Cab2p, Cab3p, Cab4p, and Cab5p as well as Sis2p and Vhs3p; null mutant lethality is complemented by E. coli coaBC","secondary_identifier":"SGD:S000001571","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL088W"}


id: YKL089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03217":null,"YKL089W":null},"has_protein_features":false,"name":"MIF2","ortholog_annotations":[{"gene_uniquename":"YKL089W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03217","reference_uniquename":"PMID:29761456"}],"product":"Centromeric CDEIII region binding protein; nucleates kinetochore assembly; required for the structural integrity of elongating spindles; copurifies with subunits of the MIND complex and centromeric nucleosome components (Cse4p and histones H2A, H2B, and H4); phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3; localizes to the kinetochore","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001572","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL089W"}


id: YKL090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01936":null,"YKL090W":null},"has_protein_features":false,"name":"CUE2","ortholog_annotations":[{"gene_uniquename":"YKL090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01936","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-binding endonuclease involved in mRNA decay; recruited to stalled ribosomes to promote breakdown of transcript body of nuclear-transcribed mRNA with stalls in translation elongation; cleaves mRNA within A site of colliding ribosome; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001573","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL090W"}


id: YKL091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03746":null,"YKL091C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YKL091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03746","reference_uniquename":"PMID:29761456"}],"product":"Putative phosphatidylinositol/phosphatidylcholine transfer protein; possibly involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study; YKL091C has a paralog, SEC14, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001574","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL091C"}


id: YKL092C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BUD2","product":"GTPase activating factor for Rsr1p/Bud1p; plays a role in spindle position checkpoint distinct from its role in bud site selection; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; contains two PH-like domains","secondary_identifier":"SGD:S000001575","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL092C"}


id: YKL093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MBR1","product":"Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; MBR1 has a paralog, ISF1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001576","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL093W"}


id: YKL094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02543":null,"YKL094W":null},"has_protein_features":false,"name":"YJU3","ortholog_annotations":[{"gene_uniquename":"YKL094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02543","reference_uniquename":"PMID:29761456"}],"product":"Monoglyceride lipase (MGL) that hydrolyzes fatty acid ethyl esters; required for removal of toxic metabolites in ethanol producing yeast cells; localizes to lipid particles and membranes; member of the eukaryotic serine hydrolase family; functional ortholog of mammalian MGL","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001577","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL094W"}


id: YKL095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01504":null,"SJAG_03427":null,"YKL095W":null},"has_protein_features":false,"name":"YJU2","ortholog_annotations":[{"gene_uniquename":"YKL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01504","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03427","reference_uniquename":"PMID:26896847"}],"product":"Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ('nineteen complex') and acts after Prp2p to promote the first catalytic reaction of splicing","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001578","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL095W"}


id: YKL096C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028667","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL096C-B"}


id: YKL096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CWP1","product":"Cell wall mannoprotein that localizes to birth scars of daughter cells; linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance","secondary_identifier":"SGD:S000001579","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL096W"}


id: YKL096W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CWP2","product":"Covalently linked cell wall mannoprotein; major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored","secondary_identifier":"SGD:S000001956","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL096W-A"}


id: YKL097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; not conserved in closely related Saccharomyces species","secondary_identifier":"SGD:S000001580","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL097C"}


id: YKL098W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MTC2","product":"Protein of unknown function; mtc2 is synthetically sick with cdc13-1","secondary_identifier":"SGD:S000001581","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL098W"}


id: YKL099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02025":null,"YKL099C":null},"has_protein_features":false,"name":"UTP11","ortholog_annotations":[{"gene_uniquename":"YKL099C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02025","reference_uniquename":"PMID:29761456"}],"product":"Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001582","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL099C"}


id: YKL100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04583":null,"YKL100C":null},"has_protein_features":false,"name":"YPF1","ortholog_annotations":[{"gene_uniquename":"YKL100C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04583","reference_uniquename":"PMID:29761456"}],"product":"Intramembrane aspartyl protease of the perinuclear ER membrane; acts in a branch of ER-associated degradation (ERAD) that degrades functional proteins rather than misfolded proteins; regulates abundance of high-affinity plasma membrane transporters, such as Ctr1p and Zrt1p, during the starvation response; has a presenilin fold; member of the GxGD family of intramembrane proteases; closest human homolog is signal peptide peptidase (SPP)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001583","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL100C"}


id: YKL100W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028840","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL100W-A"}


id: YKL101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03602":null,"SJAG_04486":null,"YKL101W":null},"has_protein_features":false,"name":"HSL1","ortholog_annotations":[{"gene_uniquename":"YKL101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03602","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04486","reference_uniquename":"PMID:29761456"}],"product":"Nim1p-related protein kinase; septin-binding kinase that localizes to the bud neck septin ring and regulates the morphogenesis checkpoint; phosphorylates Hsl7p and cooperates with Elm1p to recruit Hsl7p to the mother-bud neck, as a prerequisite for the subsequent recruitment, phosphorylation, and degradation of Swe1p; autophosphorylation enhances interactions with Hsl7p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001584","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL101W"}


id: YKL102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site","secondary_identifier":"SGD:S000001585","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL102C"}


id: YKL103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"APE1","product":"Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress","secondary_identifier":"SGD:S000001586","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL103C"}


id: YKL104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04728":null,"YKL104C":null},"has_protein_features":false,"name":"GFA1","ortholog_annotations":[{"gene_uniquename":"YKL104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04728","reference_uniquename":"PMID:29761456"}],"product":"Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL104C"}


id: YKL104W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Novel ORF identified by enrichment-based proteomics","secondary_identifier":"SGD:S000303811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL104W-A"}


id: YKL105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SEG2","product":"Eisosome component; likely plays only a minor role in eisosome assembly; shown to interact with Seg1p by affinity purification and mass spec; SWAT-GFP and mCherry fusion proteins localize to the cell periphery; similar to <i>A. gossypii</i> SEG gene which is important for stabilizing eisosomes; SEG2 has a paralog, SEG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001588","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL105C"}


id: YKL106C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi","secondary_identifier":"SGD:S000007616","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL106C-A"}


id: YKL106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00714":null,"YKL106W":null},"has_protein_features":false,"name":"AAT1","ortholog_annotations":[{"gene_uniquename":"YKL106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00714","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001589","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL106W"}


id: YKL107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"NADH-dependent aldehyde reductase; involved in the detoxification of acetaldehyde, glycolaldehyde, furfural, formaldehyde and propionaldehyde; localizes to the endoplasmic reticulum; member of the classical short-chain dehydrogenase/reductase (SDR) family","secondary_identifier":"SGD:S000001590","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL107W"}


id: YKL108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04995":null,"YKL108W":null},"has_protein_features":false,"name":"SLD2","ortholog_annotations":[{"gene_uniquename":"YKL108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04995","reference_uniquename":"PMID:29761456"}],"product":"Single-stranded DNA origin-binding and annealing protein; required for initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; binds the Mcm2-7p complex to prevent inappropriate Mcm2-7p interaction with the GINS complex in G1; required for S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001591","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL108W"}


id: YKL109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04607":null,"YKL109W":null},"has_protein_features":false,"name":"HAP4","ortholog_annotations":[{"gene_uniquename":"YKL109W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04607","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor; subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex; involved in diauxic shift","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001592","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL109W"}


