# genes

id: YHL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MCO14","product":"Putative 4a-hydroxytetrahydrobiopterin dehydratase; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000001010","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL018W"}


id: YHL019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"APM2","product":"Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport","secondary_identifier":"SGD:S000001011","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL019C"}


id: YHL019W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene APM2/YHL019C","secondary_identifier":"SGD:S000028772","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL019W-A"}


id: YHL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OPI1","product":"Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance; null exhibits disrupted mitochondrial metabolism and low cardiolipin content, strongly correlated with overproduction of inositol; binds to phosphatidic acid","secondary_identifier":"SGD:S000001012","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL020C"}


id: YHL021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AIM17","product":"Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss","secondary_identifier":"SGD:S000001013","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL021C"}


id: YHL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05295":null,"YHL022C":null},"has_protein_features":false,"name":"SPO11","ortholog_annotations":[{"gene_uniquename":"YHL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05295","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein required for meiotic recombination; makes DNA double-strand breaks (DSB) during meiotic recombination, homolog pairing, and synaptonemal complex formation; role in meiotic DSB formation involves a topo-II-like transesterase mechanism; forms monotetrameric complex; covalently linked to DSBs through a 5'-phosphodiester bond between a catalytic tyrosine (Y135) and the DSB 5'- end; sequence similarity to a topo VI subunit from archaea, fission yeast rec12 and human SPO11","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001014","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL022C"}


id: YHL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01184":null,"YHL023C":null},"has_protein_features":false,"name":"NPR3","ortholog_annotations":[{"gene_uniquename":"YHL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01184","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of SEAC, a coatomer-related complex that associates dynamically with the vacuole; Npr3p may have a structural or regulatory role, supporting Iml1p function as a GAP for the Rag family GTPase Gtr1p, and leading to inhibition of TORC1 signaling in response to amino acid deprivation; SEACIT is required for non-nitrogen-starvation-induced autophagy; null mutant has meiotic defects; human NPRL3 homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001015","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL023C"}


id: YHL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01919":null,"YHL024W":null},"has_protein_features":false,"name":"RIM4","ortholog_annotations":[{"gene_uniquename":"YHL024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01919","reference_uniquename":"PMID:29761456"}],"product":"Putative RNA-binding protein; involved in regulation of early and middle sporulation genes; forms amyloid-like aggregates under starvation that are active in translational repression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001016","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL024W"}


id: YHL025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SNF6","product":"Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions","secondary_identifier":"SGD:S000001017","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL025W"}


id: YHL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02612":null,"YHL026C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02612","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; SWAT-GFP fusion protein localizes to the cell periphery, while mCherry fusion localizes to both the cell periphery and vacuole; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001018","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL026C"}


id: YHL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RIM101","product":"Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC","secondary_identifier":"SGD:S000001019","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL027W"}


id: YHL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02258":null,"YHL028W":null},"has_protein_features":false,"name":"WSC4","ortholog_annotations":[{"gene_uniquename":"YHL028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02258","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum (ER) membrane protein; involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001020","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL028W"}


id: YHL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OCA5","product":"Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts","secondary_identifier":"SGD:S000001021","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL029C"}


id: YHL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00126":null,"YHL030W":null},"has_protein_features":false,"name":"ECM29","ortholog_annotations":[{"gene_uniquename":"YHL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00126","reference_uniquename":"PMID:29761456"}],"product":"Scaffold protein; assists in association of proteasome core particle with regulatory particle; inhibitor of proteasome in vivo and in vitro; inhibits proteasomal ATPase activity; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001022","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL030W"}


id: YHL030W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene GOS1/YHL031C","secondary_identifier":"SGD:S000028773","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL030W-A"}


id: YHL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04739":null,"YHL031C":null},"has_protein_features":false,"name":"GOS1","ortholog_annotations":[{"gene_uniquename":"YHL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04739","reference_uniquename":"PMID:29761456"}],"product":"v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001023","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL031C"}


id: YHL032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GUT1","product":"Glycerol kinase; converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p","secondary_identifier":"SGD:S000001024","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL032C"}


id: YHL033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00537":null,"YHL033C":null},"has_protein_features":false,"name":"RPL8A","ortholog_annotations":[{"gene_uniquename":"YHL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00537","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB during assembly of large subunit; binds Domain I of 25S, 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; RPL8A has paralog RPL8B from whole genome duplication; RPL8A or RPL8B ribosomes not functionally interchangeable; proportions of Rpl8ap, Rpl8bp in 80S ribosome differ in glucose and glycerol; homologous to mammalian ribosomal protein L7A, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001025","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL033C"}


id: YHL034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SBP1","product":"Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; binds to mRNAs under glucose starvation stress, most often in the 5' UTR; found associated with small nucleolar RNAs snR10 and snR11; SBP1 has a paralog, RNP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001026","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL034C"}


id: YHL034W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SBP1/YHL034C","secondary_identifier":"SGD:S000028774","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL034W-A"}


id: YHL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01344":null,"SJAG_03785":null,"SJAG_05213":null,"YHL035C":null},"has_protein_features":false,"name":"VMR1","ortholog_annotations":[{"gene_uniquename":"YHL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01344","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03785","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05213","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane protein; involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; VMR1 has a paralog, YBT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001027","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL035C"}


id: YHL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MUP3","product":"Low affinity methionine permease; similar to Mup1p","secondary_identifier":"SGD:S000001028","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL036W"}


id: YHL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000001029","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL037C"}


id: YHL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CBP2","product":"Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene","secondary_identifier":"SGD:S000001030","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL038C"}


id: YHL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02692":null,"SJAG_03228":null,"YHL039W":null},"has_protein_features":false,"name":"EFM1","ortholog_annotations":[{"gene_uniquename":"YHL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02692","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03228","reference_uniquename":"PMID:29761456"}],"product":"Lysine methyltransferase; involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001031","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL039W"}


id: YHL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YHL040C":null},"has_protein_features":false,"name":"ARN1","ortholog_annotations":[{"gene_uniquename":"YHL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001032","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL040C"}


id: YHL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000001033","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL041W"}


id: YHL042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Endoplasmic reticulum protein; member of DUP380 subfamily of conserved, often subtelomerically-encoded proteins; may contribute to maintenance of ER and nuclear morphology; null mutants have distorted nuclear envelope shape, and discontinuous, misshapen perinuclear ER","secondary_identifier":"SGD:S000001034","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL042W"}


id: YHL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ECM34","product":"Protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; SWAT-GFP, seamless-GFP and mCherry C-terminal fusion proteins localize to the cytosol","secondary_identifier":"SGD:S000001035","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL043W"}


id: YHL044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative integral membrane protein; member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern","secondary_identifier":"SGD:S000001036","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL044W"}


id: YHL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; not an essential gene","secondary_identifier":"SGD:S000001037","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL045W"}


id: YHL046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU13","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","secondary_identifier":"SGD:S000001038","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL046C"}


id: YHL046W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF ARN2/YHL047C","secondary_identifier":"SGD:S000028775","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL046W-A"}


id: YHL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YHL047C":null},"has_protein_features":false,"name":"ARN2","ortholog_annotations":[{"gene_uniquename":"YHL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"Transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001039","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL047C"}


id: YHL048C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028829","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL048C-A"}


id: YHL048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COS8","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000001040","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL048W"}


id: YHL049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001041","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL049C"}


id: YHL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; potential Cdc28p substrate","secondary_identifier":"SGD:S000001042","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL050C"}


id: YHL050W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHL050W-A"}


id: YHR001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01590":null,"SJAG_02323":null,"SJAG_02375":null,"SJAG_03718":null,"YHR001W":null},"has_protein_features":false,"name":"OSH7","ortholog_annotations":[{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01590","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02323","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02375","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03718","reference_uniquename":"PMID:29761456"}],"product":"Oxysterol-binding phosphatidylserine transferase; part of family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH7 has a paralog, OSH6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001043","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR001W"}


id: YHR001W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_07006":null,"YHR001W-A":null},"has_protein_features":false,"name":"QCR10","ortholog_annotations":[{"gene_uniquename":"YHR001W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07006","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ubiqunol-cytochrome c oxidoreductase complex; this complex comprises part of the mitochondrial respiratory chain; members include Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003529","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR001W-A"}


id: YHR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03452":null,"YHR002W":null},"has_protein_features":false,"name":"LEU5","ortholog_annotations":[{"gene_uniquename":"YHR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03452","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial carrier protein; involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein SLC25A16, which complements yeast null mutant; does not encode an isozyme of Leu4p, as first hypothesized","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001044","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR002W"}


id: YHR003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02084":null,"YHR003C":null},"has_protein_features":false,"name":"TCD1","ortholog_annotations":[{"gene_uniquename":"YHR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02084","reference_uniquename":"PMID:29761456"}],"product":"tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD1 has a paralog, TCD2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001045","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR003C"}


id: YHR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01906":null,"YHR004C":null},"has_protein_features":false,"name":"NEM1","ortholog_annotations":[{"gene_uniquename":"YHR004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01906","reference_uniquename":"PMID:29761456"}],"product":"Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001046","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR004C"}


id: YHR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02233":null,"SJAG_02444":null,"YHR005C":null},"has_protein_features":false,"name":"GPA1","ortholog_annotations":[{"gene_uniquename":"YHR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02233","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02444","reference_uniquename":"PMID:26896847"}],"product":"Subunit of G protein involved in pheromone response; GTP-binding alpha subunit of heterotrimeric G protein; negatively regulates mating pathway by sequestering G(beta)gamma and triggering an adaptive response; activates Vps34p at endosome; protein abundance increases in response to DNA replication stress; mutations in human homolog GNAS associated with McCune-Albright syndrome","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001047","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR005C"}


id: YHR005C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00687":null,"YHR005C-A":null},"has_protein_features":false,"name":"TIM10","ortholog_annotations":[{"gene_uniquename":"YHR005C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00687","reference_uniquename":"PMID:29761456"}],"product":"Essential protein of the mitochondrial intermembrane space; forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003530","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR005C-A"}


id: YHR006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"STP2","product":"Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001048","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR006W"}


id: YHR007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03750":null,"YHR007C":null},"has_protein_features":false,"name":"ERG11","ortholog_annotations":[{"gene_uniquename":"YHR007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03750","reference_uniquename":"PMID:29761456"}],"product":"Lanosterol 14-alpha-demethylase; catalyzes C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in ergosterol biosynthesis pathway; transcriptionally down-regulated when ergosterol is in excess; member of cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; human CYP51A1 functionally complements the lethality of the erg11 null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001049","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR007C"}


id: YHR007C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry; SWAT-GFP fusion protein localizes to the nucleus","secondary_identifier":"SGD:S000028830","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR007C-A"}


id: YHR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03303":null,"YHR008C":null},"has_protein_features":false,"name":"SOD2","ortholog_annotations":[{"gene_uniquename":"YHR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03303","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity and oxidative stress; human mitochondrial SOD2 can complement a yeast null mutant and human cytoplasmic SOD1 can also complement when targeted to the mitochondrial matrix","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001050","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR008C"}


id: YHR009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00287":null,"SJAG_04359":null,"YHR009C":null},"has_protein_features":false,"name":"TDA3","ortholog_annotations":[{"gene_uniquename":"YHR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00287","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04359","reference_uniquename":"PMID:29761456"}],"product":"Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001051","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR009C"}


id: YHR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01588":null,"SJAG_02802":null,"YHR010W":null},"has_protein_features":false,"name":"RPL27A","ortholog_annotations":[{"gene_uniquename":"YHR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01588","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02802","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001052","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR010W"}


id: YHR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02977":null,"YHR011W":null},"has_protein_features":false,"name":"DIA4","ortholog_annotations":[{"gene_uniquename":"YHR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02977","reference_uniquename":"PMID:29761456"}],"product":"Probable mitochondrial seryl-tRNA synthetase; mutant displays increased invasive and pseudohyphal growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001053","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR011W"}


id: YHR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04629":null,"YHR012W":null},"has_protein_features":false,"name":"VPS29","ortholog_annotations":[{"gene_uniquename":"YHR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04629","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the membrane-associated retromer complex; endosomal protein; essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001054","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR012W"}


id: YHR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04631":null,"YHR013C":null},"has_protein_features":false,"name":"ARD1","ortholog_annotations":[{"gene_uniquename":"YHR013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04631","reference_uniquename":"PMID:29761456"}],"product":"Subunit of protein N-terminal acetyltransferase NatA; NatA comprises Nat1p, Ard1p, Nat5p; acetylates many proteins to influence telomeric silencing, cell cycle, heat-shock resistance, mating, sporulation, early stages of mitophagy; protein abundance increases under DNA replication stress; mutations in human homolog X-linked NAA10 lead to Ogden syndrome (S37P) and intellectual disability (R116W); expression of human NAA10 and NAA15 can complement ard1 nat1 double mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001055","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR013C"}


id: YHR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPO13","product":"Meiotic regulator; involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II; anaphase-promoting complex (APC) substrate that is degraded during anaphase I; expressed only in meiotic cells","secondary_identifier":"SGD:S000001056","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR014W"}


id: YHR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MIP6","product":"Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001057","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR015W"}


id: YHR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00970":null,"YHR016C":null},"has_protein_features":false,"name":"YSC84","ortholog_annotations":[{"gene_uniquename":"YHR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00970","reference_uniquename":"PMID:29761456"}],"product":"Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001058","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR016C"}


id: YHR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04124":null,"YHR017W":null},"has_protein_features":false,"name":"YSC83","ortholog_annotations":[{"gene_uniquename":"YHR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04124","reference_uniquename":"PMID:29761456"}],"product":"Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001059","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR017W"}


id: YHR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01461":null,"YHR018C":null},"has_protein_features":false,"name":"ARG4","ortholog_annotations":[{"gene_uniquename":"YHR018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01461","reference_uniquename":"PMID:29761456"}],"product":"Argininosuccinate lyase; catalyzes the final step in the arginine biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001060","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR018C"}


id: YHR019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02517":null,"YHR019C":null},"has_protein_features":false,"name":"DED81","ortholog_annotations":[{"gene_uniquename":"YHR019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02517","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic asparaginyl-tRNA synthetase; required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001061","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR019C"}


id: YHR020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01259":null,"YHR020W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHR020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01259","reference_uniquename":"PMID:29761456"}],"product":"Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001062","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR020W"}


id: YHR021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02340":null,"YHR021C":null},"has_protein_features":false,"name":"RPS27B","ortholog_annotations":[{"gene_uniquename":"YHR021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02340","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001063","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR021C"}


id: YHR021W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ECM12","product":"Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity","secondary_identifier":"SGD:S000003531","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR021W-A"}


id: YHR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YHR022C is not an essential gene","secondary_identifier":"SGD:S000001064","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR022C"}


id: YHR022C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR022C-A"}


id: YHR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02431":null,"SJAG_03703":null,"YHR023W":null},"has_protein_features":false,"name":"MYO1","ortholog_annotations":[{"gene_uniquename":"YHR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02431","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03703","reference_uniquename":"PMID:29761456"}],"product":"Type II myosin heavy chain; required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001065","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR023W"}


id: YHR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04641":null,"YHR024C":null},"has_protein_features":false,"name":"MAS2","ortholog_annotations":[{"gene_uniquename":"YHR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04641","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001066","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR024C"}


id: YHR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03141":null,"YHR025W":null},"has_protein_features":false,"name":"THR1","ortholog_annotations":[{"gene_uniquename":"YHR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03141","reference_uniquename":"PMID:29761456"}],"product":"Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulated by the GCN4-mediated general amino acid control pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001067","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR025W"}


id: YHR026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02023":null,"YHR026W":null},"has_protein_features":false,"name":"VMA16","ortholog_annotations":[{"gene_uniquename":"YHR026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02023","reference_uniquename":"PMID:29761456"}],"product":"Subunit c'' of the vacuolar ATPase; v-ATPase functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001068","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR026W"}


id: YHR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03638":null,"YHR027C":null},"has_protein_features":false,"name":"RPN1","ortholog_annotations":[{"gene_uniquename":"YHR027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03638","reference_uniquename":"PMID:29761456"}],"product":"Non-ATPase base subunit of the 19S RP of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions; RP is the acronym for regulatory particle","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001069","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR027C"}


id: YHR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02565":null,"YHR028C":null},"has_protein_features":false,"name":"DAP2","ortholog_annotations":[{"gene_uniquename":"YHR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02565","reference_uniquename":"PMID:29761456"}],"product":"Dipeptidyl aminopeptidase; synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001070","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR028C"}


id: YHR028W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF DAP2/YHR028C","secondary_identifier":"SGD:S000028776","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR028W-A"}


id: YHR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YHI9","product":"Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production","secondary_identifier":"SGD:S000001071","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR029C"}


id: YHR030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04551":null,"YHR030C":null},"has_protein_features":false,"name":"SLT2","ortholog_annotations":[{"gene_uniquename":"YHR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04551","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine MAP kinase; coordinates expression of all 19S regulatory particle assembly-chaperones (RACs) to control proteasome abundance; involved in regulating maintenance of cell wall integrity, cell cycle progression, nuclear mRNA retention in heat shock, septum assembly; required for mitophagy, pexophagy; affects recruitment of mitochondria to phagophore assembly site; plays role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001072","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR030C"}


id: YHR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03780":null,"YHR031C":null},"has_protein_features":false,"name":"RRM3","ortholog_annotations":[{"gene_uniquename":"YHR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03780","reference_uniquename":"PMID:29761456"}],"product":"DNA helicase involved in rDNA replication and Ty1 transposition; binds to and suppresses DNA damage at G4 motifs in vivo; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001073","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR031C"}


id: YHR032C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032W-A","secondary_identifier":"SGD:S000028646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR032C-A"}


id: YHR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01145":null,"SJAG_03951":null,"YHR032W":null},"has_protein_features":false,"name":"ERC1","ortholog_annotations":[{"gene_uniquename":"YHR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01145","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03951","reference_uniquename":"PMID:29761456"}],"product":"Member of the multi-drug and toxin extrusion (MATE) family; the MATE family is part of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001074","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR032W"}


id: YHR032W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A","secondary_identifier":"SGD:S000028831","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR032W-A"}


id: YHR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03457":null,"YHR033W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03457","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001075","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR033W"}


id: YHR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PIH1","product":"Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II","secondary_identifier":"SGD:S000001076","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR034C"}


id: YHR035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NEL1","product":"Activator of Sar1p GTPase activity; paralog of Sec23 but does not associate with the COPII components; not an essential gene","secondary_identifier":"SGD:S000001077","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR035W"}


id: YHR036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01422":null,"YHR036W":null},"has_protein_features":false,"name":"BRL1","ortholog_annotations":[{"gene_uniquename":"YHR036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01422","reference_uniquename":"PMID:29761456"}],"product":"Essential nuclear envelope/ER integral membrane protein; interacts and functions with Apq12p and Brr6p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, mRNA nuclear export and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; identified as a dosage suppressor of a temperature sensitive mutation in the major karyopherin, CRM1; homologous to Brr6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001078","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR036W"}


id: YHR037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02235":null,"YHR037W":null},"has_protein_features":false,"name":"PUT2","ortholog_annotations":[{"gene_uniquename":"YHR037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02235","reference_uniquename":"PMID:29761456"}],"product":"Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of human homolog ALDH4A1 causes type II hyperprolinemia (HPII), an autosomal recessive inborn error of metabolism; human homolog ALDH4A1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001079","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR037W"}


id: YHR038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03232":null,"YHR038W":null},"has_protein_features":false,"name":"RRF1","ortholog_annotations":[{"gene_uniquename":"YHR038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03232","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosome recycling factor; essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001080","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR038W"}


id: YHR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00482":null,"YHR039C":null},"has_protein_features":false,"name":"MSC7","ortholog_annotations":[{"gene_uniquename":"YHR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00482","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001081","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR039C"}


id: YHR039C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01447":null,"YHR039C-A":null},"has_protein_features":false,"name":"VMA10","ortholog_annotations":[{"gene_uniquename":"YHR039C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01447","reference_uniquename":"PMID:29761456"}],"product":"Subunit G of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002100","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR039C-A"}


id: YHR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00752":null,"YHR040W":null},"has_protein_features":false,"name":"BCD1","ortholog_annotations":[{"gene_uniquename":"YHR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00752","reference_uniquename":"PMID:29761456"}],"product":"Essential protein required for the accumulation of box C/D snoRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001082","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR040W"}


id: YHR041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04099":null,"YHR041C":null},"has_protein_features":false,"name":"SRB2","ortholog_annotations":[{"gene_uniquename":"YHR041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04099","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001083","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR041C"}


id: YHR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04270":null,"YHR042W":null},"has_protein_features":false,"name":"NCP1","ortholog_annotations":[{"gene_uniquename":"YHR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04270","reference_uniquename":"PMID:29761456"}],"product":"NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001084","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR042W"}


id: YHR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DOG2","product":"2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed; DOG2 has a paralog, DOG1, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae","secondary_identifier":"SGD:S000001085","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR043C"}


id: YHR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DOG1","product":"2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed; DOG1 has a paralog, DOG2, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae","secondary_identifier":"SGD:S000001086","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR044C"}


id: YHR045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum","secondary_identifier":"SGD:S000001087","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR045W"}


id: YHR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"INM1","product":"Inositol monophosphatase; involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate","secondary_identifier":"SGD:S000001088","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR046C"}


id: YHR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00181":null,"YHR047C":null},"has_protein_features":false,"name":"AAP1","ortholog_annotations":[{"gene_uniquename":"YHR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00181","reference_uniquename":"PMID:29761456"}],"product":"Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001089","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR047C"}


id: YHR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02344":null,"YHR048W":null},"has_protein_features":false,"name":"YHK8","ortholog_annotations":[{"gene_uniquename":"YHR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02344","reference_uniquename":"PMID:26896847"}],"product":"Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001090","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR048W"}


id: YHR049C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003532","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR049C-A"}


id: YHR049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03760":null,"YHR049W":null},"has_protein_features":false,"name":"FSH1","ortholog_annotations":[{"gene_uniquename":"YHR049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03760","reference_uniquename":"PMID:26896847"}],"product":"Lysophospholipase; hydrolyzes lysophosphatidylserine to release free fatty acid; involved in regulated cell death; localizes to both the nucleus and cytoplasm; contains a catalytic triad of Ser-His-Asp that is part of an alpha/beta hydrolase fold and a lipase motif (GXSXG); sequence similarity to Fsh2p and Fsh3p and the human candidate tumor suppressor and serine hydrolase, OVCA2","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001091","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR049W"}


id: YHR050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01007":null,"YHR050W":null},"has_protein_features":false,"name":"SMF2","ortholog_annotations":[{"gene_uniquename":"YHR050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01007","reference_uniquename":"PMID:29761456"}],"product":"Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001092","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR050W"}


id: YHR050W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028832","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR050W-A"}


id: YHR051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01355":null,"YHR051W":null},"has_protein_features":false,"name":"COX6","ortholog_annotations":[{"gene_uniquename":"YHR051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01355","reference_uniquename":"PMID:29761456"}],"product":"Subunit VI of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001093","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR051W"}


id: YHR052C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Novel ORF identified by enrichment-based proteomics","secondary_identifier":"SGD:S000303807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR052C-B"}


id: YHR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01420":null,"SJAG_01752":null,"YHR052W":null},"has_protein_features":false,"name":"CIC1","ortholog_annotations":[{"gene_uniquename":"YHR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01420","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01752","reference_uniquename":"PMID:29761456"}],"product":"Essential protein that interacts with proteasome components; has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001094","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR052W"}


id: YHR052W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps CUP1-1","secondary_identifier":"SGD:S000028647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR052W-A"}


id: YHR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CUP1-1","product":"Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-1 has a paralog, CUP1-2, that arose from a segmental duplication","secondary_identifier":"SGD:S000001095","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR053C"}


id: YHR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; partial duplicate of RSC30/YHR056C, truncated remnant of segmental duplication","secondary_identifier":"SGD:S000001096","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR054C"}


id: YHR054C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Novel ORF identified by enrichment-based proteomics","secondary_identifier":"SGD:S000303808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR054C-B"}


id: YHR054W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps CUP1-2","secondary_identifier":"SGD:S000028648","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR054W-A"}


id: YHR055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CUP1-2","product":"Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-2 has a paralog, CUP1-1, that arose from a segmental duplication","secondary_identifier":"SGD:S000001097","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR055C"}


id: YHR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RSC30","product":"Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; null mutants are osmosensitive; RSC30 has a paralog, RSC3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001098","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR056C"}


id: YHR056W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps ORF RSC30/YHR056C","secondary_identifier":"SGD:S000028777","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR056W-A"}


id: YHR057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02413":null,"YHR057C":null},"has_protein_features":false,"name":"CPR2","ortholog_annotations":[{"gene_uniquename":"YHR057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02413","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; seamless-GFP and mCherry fusion proteins localize to the vacuole, while SWAT-GFP fusion localizes to both the endoplasmic reticulum and vacuole; suppresses toxicity of slow-folding human Z-type alpha1-antitrypsin variant associated with liver cirrhosis and emphysema","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001099","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR057C"}


id: YHR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04705":null,"YHR058C":null},"has_protein_features":false,"name":"MED6","ortholog_annotations":[{"gene_uniquename":"YHR058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04705","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001100","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR058C"}


id: YHR059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00060":null,"YHR059W":null},"has_protein_features":false,"name":"FYV4","ortholog_annotations":[{"gene_uniquename":"YHR059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00060","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; required for survival upon exposure to K1 killer toxin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001101","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR059W"}


id: YHR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"VMA22","product":"Protein that is required for vacuolar H+-ATPase (V-ATPase) function; peripheral membrane protein; not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)","secondary_identifier":"SGD:S000001102","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR060W"}


id: YHR061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GIC1","product":"Rho-family GTPase interacting protein and Cdc42p effector; required with Gic2p for polarity establishment and initiation of budding; involved in recruitment of septins to the presumptive bud site; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; gic1 gic2 double mutants are defective for polarizing Cdc42p at elevated temperature, so may function both up- and downstream of Cdc42p; regulates mitotic exit; relocalizes from bud neck to nucleus upon DNA replication stress","secondary_identifier":"SGD:S000001103","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR061C"}


id: YHR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04916":null,"YHR062C":null},"has_protein_features":false,"name":"RPP1","ortholog_annotations":[{"gene_uniquename":"YHR062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04916","reference_uniquename":"PMID:29761456"}],"product":"Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001104","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR062C"}


id: YHR063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAN5","product":"2-dehydropantoate 2-reductase; part of the pantothenic acid pathway, structurally homologous to E. coli panE","secondary_identifier":"SGD:S000001105","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR063C"}


id: YHR063W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF SSZ1/YHR064C","secondary_identifier":"SGD:S000028778","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR063W-A"}


id: YHR064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01510":null,"YHR064C":null},"has_protein_features":false,"name":"SSZ1","ortholog_annotations":[{"gene_uniquename":"YHR064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01510","reference_uniquename":"PMID:29761456"}],"product":"Hsp70 protein that interacts with Zuo1p (a DnaJ homolog); interacts with Zuo1p to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001106","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR064C"}


id: YHR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04974":null,"YHR065C":null},"has_protein_features":false,"name":"RRP3","ortholog_annotations":[{"gene_uniquename":"YHR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04974","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001107","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR065C"}


id: YHR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02427":null,"YHR066W":null},"has_protein_features":false,"name":"SSF1","ortholog_annotations":[{"gene_uniquename":"YHR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02427","reference_uniquename":"PMID:29761456"}],"product":"Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001108","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR066W"}


id: YHR067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00305":null,"YHR067W":null},"has_protein_features":false,"name":"HTD2","ortholog_annotations":[{"gene_uniquename":"YHR067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00305","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial 3-hydroxyacyl-thioester dehydratase; involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001109","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR067W"}


id: YHR068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04130":null,"YHR068W":null},"has_protein_features":false,"name":"DYS1","ortholog_annotations":[{"gene_uniquename":"YHR068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04130","reference_uniquename":"PMID:29761456"}],"product":"Deoxyhypusine synthase; catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric; human homolog DHPS allows growth of yeast haploid dys1 null mutant after sporulation of heterozygous diploid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001110","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR068W"}


id: YHR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01521":null,"YHR069C":null},"has_protein_features":false,"name":"RRP4","ortholog_annotations":[{"gene_uniquename":"YHR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01521","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; mutations in the human ortholog, EXOSC2, cause SHRF (Short stature, Hearing loss, Retinitis pigmentosa and distinctive Facies) syndrome, an RNA exosomopathy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001111","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR069C"}


id: YHR069C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps ORF TRM5/YHR070W","secondary_identifier":"SGD:S000028779","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR069C-A"}


id: YHR070C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W","secondary_identifier":"SGD:S000028780","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR070C-A"}


id: YHR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00255":null,"YHR070W":null},"has_protein_features":false,"name":"TRM5","ortholog_annotations":[{"gene_uniquename":"YHR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00255","reference_uniquename":"PMID:29761456"}],"product":"tRNA(m(1)G37)methyltransferase; methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; localized to both cytoplasm and mitochondria, and modifies both cytoplasmic and mitochondrial tRNAs; mutations in human ortholog TRMT5 are associated with skeletal muscle respiratory chain deficiencies, and trm5 mutations analogous to disease mutations decrease respiration","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001112","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR070W"}


id: YHR071C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ERG7/YHR072W","secondary_identifier":"SGD:S000028781","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR071C-A"}


id: YHR071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03591":null,"YHR071W":null},"has_protein_features":false,"name":"PCL5","ortholog_annotations":[{"gene_uniquename":"YHR071W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03591","reference_uniquename":"PMID:29761456"}],"product":"Cyclin; interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001113","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR071W"}


id: YHR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00624":null,"YHR072W":null},"has_protein_features":false,"name":"ERG7","ortholog_annotations":[{"gene_uniquename":"YHR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00624","reference_uniquename":"PMID:29761456"}],"product":"Lanosterol synthase; an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis; human LSS functionally complements the lethality of the erg7 null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001114","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR072W"}


id: YHR072W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00566":null,"YHR072W-A":null},"has_protein_features":false,"name":"NOP10","ortholog_annotations":[{"gene_uniquename":"YHR072W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00566","reference_uniquename":"PMID:29761456"}],"product":"Subunit of box H/ACA snoRNP complex; required for pseudouridylation and processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR072W-A"}


id: YHR073C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028833","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR073C-B"}


id: YHR073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00355":null,"YHR073W":null},"has_protein_features":false,"name":"OSH3","ortholog_annotations":[{"gene_uniquename":"YHR073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00355","reference_uniquename":"PMID:29761456"}],"product":"Member of an oxysterol-binding protein family; this family has seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane; regulated by sterol binding","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001115","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR073W"}


id: YHR073W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028834","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR073W-A"}


id: YHR074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02618":null,"YHR074W":null},"has_protein_features":false,"name":"QNS1","ortholog_annotations":[{"gene_uniquename":"YHR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02618","reference_uniquename":"PMID:29761456"}],"product":"Glutamine-dependent NAD(+) synthetase; essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001116","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR074W"}


id: YHR075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01628":null,"YHR075C":null},"has_protein_features":false,"name":"PPE1","ortholog_annotations":[{"gene_uniquename":"YHR075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01628","reference_uniquename":"PMID:29761456"}],"product":"Protein with carboxyl methyl esterase activity; may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001117","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR075C"}


id: YHR076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01672":null,"YHR076W":null},"has_protein_features":false,"name":"PTC7","ortholog_annotations":[{"gene_uniquename":"YHR076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01672","reference_uniquename":"PMID:29761456"}],"product":"Type 2C serine/threonine protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope; activates coenzyme Q6 biosynthesis by dephosphorylation of demethoxy-Q6 hydroxylase Coq7p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001118","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR076W"}


id: YHR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05014":null,"YHR077C":null},"has_protein_features":false,"name":"NMD2","ortholog_annotations":[{"gene_uniquename":"YHR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05014","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001119","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR077C"}


id: YHR078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"High osmolarity-regulated gene of unknown function","secondary_identifier":"SGD:S000001120","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR078W"}


id: YHR079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04435":null,"YHR079C":null},"has_protein_features":false,"name":"IRE1","ortholog_annotations":[{"gene_uniquename":"YHR079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04435","reference_uniquename":"PMID:29761456"}],"product":"Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001121","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR079C"}


id: YHR079C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03221":null,"YHR079C-A":null},"has_protein_features":false,"name":"SAE3","ortholog_annotations":[{"gene_uniquename":"YHR079C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03221","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001957","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR079C-A"}


id: YHR080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01329":null,"YHR080C":null},"has_protein_features":false,"name":"LAM4","ortholog_annotations":[{"gene_uniquename":"YHR080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01329","reference_uniquename":"PMID:29761456"}],"product":"Sterol-binding protein that localizes to puncta in the cortical ER; sterol binding occurs via two StART-like domains; one of six StART-like domain-containing proteins in yeast that may be involved in intracellular sterol transfer between membranes; conserved across eukaryotes; has both GRAM and StART-like (VASt) domains; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001122","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR080C"}


id: YHR081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01191":null,"YHR081W":null},"has_protein_features":false,"name":"LRP1","ortholog_annotations":[{"gene_uniquename":"YHR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01191","reference_uniquename":"PMID:29761456"}],"product":"Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; forms a stable heterodimer with Rrp6p and regulates its exonucleolytic activity; rapidly degraded by the proteasome in the absence of Rrp6p; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001123","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR081W"}


id: YHR082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03529":null,"YHR082C":null},"has_protein_features":false,"name":"KSP1","ortholog_annotations":[{"gene_uniquename":"YHR082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03529","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001124","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR082C"}


id: YHR083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01780":null,"YHR083W":null},"has_protein_features":false,"name":"SAM35","ortholog_annotations":[{"gene_uniquename":"YHR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01780","reference_uniquename":"PMID:29761456"}],"product":"Component of the sorting and assembly machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001125","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR083W"}


id: YHR084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"STE12","product":"Transcription factor that is activated by a MAPK signaling cascade; activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth","secondary_identifier":"SGD:S000001126","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR084W"}


id: YHR085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04252":null,"YHR085W":null},"has_protein_features":false,"name":"IPI1","ortholog_annotations":[{"gene_uniquename":"YHR085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04252","reference_uniquename":"PMID:29761456"}],"product":"Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001127","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR085W"}


id: YHR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00474":null,"SJAG_02573":null,"YHR086W":null},"has_protein_features":false,"name":"NAM8","ortholog_annotations":[{"gene_uniquename":"YHR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00474","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02573","reference_uniquename":"PMID:26896847"}],"product":"RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001128","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR086W"}


id: YHR086W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","secondary_identifier":"SGD:S000028552","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR086W-A"}


id: YHR087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00487":null,"YHR087W":null},"has_protein_features":false,"name":"RTC3","ortholog_annotations":[{"gene_uniquename":"YHR087W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00487","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog is SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001129","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR087W"}


id: YHR088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04492":null,"YHR088W":null},"has_protein_features":false,"name":"RPF1","ortholog_annotations":[{"gene_uniquename":"YHR088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04492","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in assembly and export of the large ribosomal subunit; nucleolar protein; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001130","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR088W"}


id: YHR089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01234":null,"YHR089C":null},"has_protein_features":false,"name":"GAR1","ortholog_annotations":[{"gene_uniquename":"YHR089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01234","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the H/ACA snoRNP pseudouridylase complex; involved in the modification and cleavage of the 18S pre-rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001131","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR089C"}


id: YHR090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03230":null,"SJAG_03628":null,"YHR090C":null},"has_protein_features":false,"name":"YNG2","ortholog_annotations":[{"gene_uniquename":"YHR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03230","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03628","reference_uniquename":"PMID:29761456"}],"product":"Subunit of NuA4, an essential histone acetyltransferase complex; positions Piccolo NuA4 for efficient acetylation of histone H4 or histone H2A; relocalizes to the cytosol in response to hypoxia; similar to human tumor suppressor ING1 and its isoforms ING4 and ING5","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001132","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR090C"}


id: YHR091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00653":null,"YHR091C":null},"has_protein_features":false,"name":"MSR1","ortholog_annotations":[{"gene_uniquename":"YHR091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00653","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6; MSR1 has a paralog, YDR341C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001133","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR091C"}


id: YHR092C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YHR092C":null},"has_protein_features":false,"name":"HXT4","ortholog_annotations":[{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001134","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR092C"}


id: YHR093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AHT1","product":"Putative protein of unknown function; conserved across S. cerevisiae strains; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region","secondary_identifier":"SGD:S000001135","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR093W"}


id: YHR094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YHR094C":null},"has_protein_features":false,"name":"HXT1","ortholog_annotations":[{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001136","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR094C"}


id: YHR095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001137","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR095W"}


id: YHR096C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YHR096C":null},"has_protein_features":false,"name":"HXT5","ortholog_annotations":[{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001138","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR096C"}


id: YHR097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04050":null,"SJAG_05198":null,"YHR097C":null},"has_protein_features":false,"name":"PAL2","ortholog_annotations":[{"gene_uniquename":"YHR097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04050","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05198","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in clathrin-mediated endocytosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YHR097C has a paralog, PAL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001139","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR097C"}


id: YHR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02349":null,"YHR098C":null},"has_protein_features":false,"name":"SFB3","ortholog_annotations":[{"gene_uniquename":"YHR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02349","reference_uniquename":"PMID:29761456"}],"product":"Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat; COPII coat is required for cargo selection during vesicle formation in ER to Golgi transport; scaffolding function of Lst1p required to generate vesicles that can accommodate difficult cargo proteins that include large oligomeric assemblies and asymmetrically distributed membrane proteins; with Atg40p acts in autophagy of the ER; homologous to Sec24p and Sfb2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001140","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR098C"}


id: YHR099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04613":null,"SJAG_05282":null,"YHR099W":null},"has_protein_features":false,"name":"TRA1","ortholog_annotations":[{"gene_uniquename":"YHR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04613","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05282","reference_uniquename":"PMID:29761456"}],"product":"Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001141","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR099W"}


id: YHR100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03700":null,"YHR100C":null},"has_protein_features":false,"name":"GEP4","ortholog_annotations":[{"gene_uniquename":"YHR100C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03700","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase); dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001142","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR100C"}


id: YHR101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00771":null,"YHR101C":null},"has_protein_features":false,"name":"BIG1","ortholog_annotations":[{"gene_uniquename":"YHR101C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00771","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001143","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR101C"}


id: YHR102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04461":null,"YHR102W":null},"has_protein_features":false,"name":"KIC1","ortholog_annotations":[{"gene_uniquename":"YHR102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04461","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; phosphorylates Cbk1p kinase after allosteric activation by Hym1p; part of the RAM network that regulates cellular polarity and morphogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001144","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR102W"}


id: YHR103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SBE22","product":"Protein involved in bud growth; involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; SBE22 has a paralog, SBE2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001145","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR103W"}


id: YHR104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GRE3","product":"Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by HOG pathway; overexpression allows xylose fermentation in strains expressing heterologous xylitol dehydrogenase and xylulokinase; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000001146","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR104W"}


id: YHR105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YPT35","product":"Endosomal protein of unknown function; contains a phox (PX) homology domain; binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport","secondary_identifier":"SGD:S000001147","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR105W"}


id: YHR106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03653":null,"SJAG_04399":null,"YHR106W":null},"has_protein_features":false,"name":"TRR2","ortholog_annotations":[{"gene_uniquename":"YHR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03653","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04399","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001148","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR106W"}


id: YHR107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03374":null,"SJAG_03688":null,"YHR107C":null},"has_protein_features":false,"name":"CDC12","ortholog_annotations":[{"gene_uniquename":"YHR107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03374","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03688","reference_uniquename":"PMID:29761456"}],"product":"Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001149","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR107C"}


id: YHR108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02912":null,"SJAG_03756":null,"YHR108W":null},"has_protein_features":false,"name":"GGA2","ortholog_annotations":[{"gene_uniquename":"YHR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02912","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03756","reference_uniquename":"PMID:29761456"}],"product":"Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin; GGA2 has a paralog, GGA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001150","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR108W"}


id: YHR109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CTM1","product":"Cytochrome c lysine methyltransferase; trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth","secondary_identifier":"SGD:S000001151","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR109W"}


id: YHR110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04598":null,"YHR110W":null},"has_protein_features":false,"name":"ERP5","ortholog_annotations":[{"gene_uniquename":"YHR110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04598","reference_uniquename":"PMID:29761456"}],"product":"Protein with similarity to Emp24p and Erv25p; member of the p24 family involved in ER to Golgi transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001152","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR110W"}


id: YHR111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03896":null,"YHR111W":null},"has_protein_features":false,"name":"UBA4","ortholog_annotations":[{"gene_uniquename":"YHR111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03896","reference_uniquename":"PMID:29761456"}],"product":"E1-like protein that activates Urm1p before urmylation; also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001153","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR111W"}


id: YHR112C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02205":null,"YHR112C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHR112C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02205","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001154","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR112C"}


id: YHR113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03022":null,"YHR113W":null},"has_protein_features":false,"name":"APE4","ortholog_annotations":[{"gene_uniquename":"YHR113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03022","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic aspartyl aminopeptidase with possible vacuole function; Cvt pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001155","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR113W"}


id: YHR114W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04479":null,"YHR114W":null},"has_protein_features":false,"name":"BZZ1","ortholog_annotations":[{"gene_uniquename":"YHR114W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04479","reference_uniquename":"PMID:29761456"}],"product":"SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001156","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR114W"}


id: YHR115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02169":null,"YHR115C":null},"has_protein_features":false,"name":"DMA1","ortholog_annotations":[{"gene_uniquename":"YHR115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02169","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-protein ligase (E3); controls septin dynamics, spindle position checkpoint (SPOC) with ligase Dma2p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8, similar to human Chfr; contains FHA, RING fingers; DMA1 has a paralog, DMA2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001157","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR115C"}


id: YHR116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"COX23","product":"Protein that functions in mitochondrial copper homeostasis; mitochondrial intermembrane space protein; essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs","secondary_identifier":"SGD:S000001158","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR116W"}


id: YHR117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04996":null,"YHR117W":null},"has_protein_features":false,"name":"TOM71","ortholog_annotations":[{"gene_uniquename":"YHR117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04996","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001159","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR117W"}


id: YHR118C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01267":null,"YHR118C":null},"has_protein_features":false,"name":"ORC6","ortholog_annotations":[{"gene_uniquename":"YHR118C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01267","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p; mutation in the human Orc6p is linked to Meier-Gorlin syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001160","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR118C"}


id: YHR119W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00769":null,"YHR119W":null},"has_protein_features":false,"name":"SET1","ortholog_annotations":[{"gene_uniquename":"YHR119W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00769","reference_uniquename":"PMID:29761456"}],"product":"Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001161","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR119W"}


id: YHR120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01807":null,"YHR120W":null},"has_protein_features":false,"name":"MSH1","ortholog_annotations":[{"gene_uniquename":"YHR120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01807","reference_uniquename":"PMID:29761456"}],"product":"DNA-binding protein of the mitochondria; involved in repair of mitochondrial DNA; has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001162","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR120W"}


id: YHR121W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LSM12","product":"Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000001163","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR121W"}


id: YHR122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00040":null,"YHR122W":null},"has_protein_features":false,"name":"CIA2","ortholog_annotations":[{"gene_uniquename":"YHR122W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00040","reference_uniquename":"PMID:29761456"}],"product":"Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation and maturation of a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001164","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR122W"}


id: YHR123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04319":null,"YHR123W":null},"has_protein_features":false,"name":"EPT1","ortholog_annotations":[{"gene_uniquename":"YHR123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04319","reference_uniquename":"PMID:29761456"}],"product":"sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001165","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR123W"}


id: YHR124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NDT80","product":"Meiosis-specific transcription factor; required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)","secondary_identifier":"SGD:S000001166","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR124W"}


id: YHR125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000001167","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR125W"}


id: YHR126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ANS1","product":"Putative GPI protein; SWAT-GFP and mCherry fusion proteins localize to the vacuole; transcription dependent upon Azf1p","secondary_identifier":"SGD:S000001168","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR126C"}


id: YHR127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis","secondary_identifier":"SGD:S000001169","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR127W"}


id: YHR128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04354":null,"SJAG_04709":null,"SJAG_04713":null,"YHR128W":null},"has_protein_features":false,"name":"FUR1","ortholog_annotations":[{"gene_uniquename":"YHR128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04354","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04709","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04713","reference_uniquename":"PMID:29761456"}],"product":"Uracil phosphoribosyltransferase; synthesizes UMP from uracil; involved in the pyrimidine salvage pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001170","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR128W"}


id: YHR129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00397":null,"SJAG_01964":null,"YHR129C":null},"has_protein_features":false,"name":"ARP1","ortholog_annotations":[{"gene_uniquename":"YHR129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00397","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01964","reference_uniquename":"PMID:26896847"}],"product":"Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001171","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR129C"}


id: YHR130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YHR130C is not an essential gene","secondary_identifier":"SGD:S000001172","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR130C"}


id: YHR131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study; YHR131C has a paralog, YNL144C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001173","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR131C"}


id: YHR131W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YHR131C","secondary_identifier":"SGD:S000028782","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR131W-A"}


id: YHR132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00451":null,"YHR132C":null},"has_protein_features":false,"name":"ECM14","ortholog_annotations":[{"gene_uniquename":"YHR132C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00451","reference_uniquename":"PMID:29761456"}],"product":"Conserved fungal protein with similarity to zinc carboxypeptidases; in some strains required for normal cell wall assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001174","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR132C"}


id: YHR132W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03309":null,"YHR132W-A":null},"has_protein_features":false,"name":"IGO2","ortholog_annotations":[{"gene_uniquename":"YHR132W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03309","reference_uniquename":"PMID:29761456"}],"product":"Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; IGO2 has a paralog, IGO1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007496","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR132W-A"}


id: YHR133C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00770":null,"YHR133C":null},"has_protein_features":false,"name":"NSG1","ortholog_annotations":[{"gene_uniquename":"YHR133C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00770","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; forms foci at the nuclear periphery upon DNA replication stress; relocalizes to the cytosol in response to hypoxia; homolog of mammalian INSIG proteins; NSG1 has a paralog, NSG2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001175","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR133C"}


id: YHR134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00406":null,"YHR134W":null},"has_protein_features":false,"name":"WSS1","ortholog_annotations":[{"gene_uniquename":"YHR134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00406","reference_uniquename":"PMID:29761456"}],"product":"SUMO-ligase and SUMO-targeted metalloprotease; involved in DNA repair; removes DNA-protein crosslinks at stalled replication forks during replication of damaged DNA; clears chromatin-bound sumoylated proteins; localizes to single spot on nuclear periphery of mother cells but not daughters; exhibits vacuolar localization upon genotoxic stress; activated by DNA binding; member of minigluzincins protease family with mammalian DVC1/Spartan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001176","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR134W"}


id: YHR135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00402":null,"SJAG_01373":null,"SJAG_03987":null,"YHR135C":null},"has_protein_features":false,"name":"YCK1","ortholog_annotations":[{"gene_uniquename":"YHR135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00402","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01373","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03987","reference_uniquename":"PMID:29761456"}],"product":"Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; involved in the phosphorylation and regulation of glucose sensor Rgt2p; YCK1 has a paralog, YCK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001177","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR135C"}


id: YHR136C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPL2","product":"Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation by targeting Pho87p to the vacuole; upstream region harbors putative hypoxia response element (HRE) cluster; overproduction suppresses a plc1 null mutation; promoter shows an increase in Snf2p occupancy after heat shock; GFP-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000001178","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR136C"}


id: YHR137C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene ARO9/YHR137W; identified by gene-trapping, expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028649","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR137C-A"}


id: YHR137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03312":null,"YHR137W":null},"has_protein_features":false,"name":"ARO9","ortholog_annotations":[{"gene_uniquename":"YHR137W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03312","reference_uniquename":"PMID:29761456"}],"product":"Aromatic aminotransferase II; catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism; involved with Aro8p in production of kynurenic acid to detoxify excess tryptophan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001179","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR137W"}


id: YHR138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000001180","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR138C"}


id: YHR139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPS100","product":"Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin; SPS100 has a paralog, YGP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001181","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR139C"}


id: YHR139C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000003533","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR139C-A"}


id: YHR140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04570":null,"YHR140W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHR140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04570","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum protein; may contribute to maintenance of ER and nuclear morphology; null mutant shows discontinuity in nuclear envelope, clustering of nuclear pores, and lacks cortical ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001182","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR140W"}


id: YHR141C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04626":null,"YHR141C":null},"has_protein_features":false,"name":"RPL42B","ortholog_annotations":[{"gene_uniquename":"YHR141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04626","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001183","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR141C"}


id: YHR142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CHS7","product":"Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress","secondary_identifier":"SGD:S000001184","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR142W"}


id: YHR143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DSE2","product":"Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother; localizes in birth scars; expression is repressed by cAMP","secondary_identifier":"SGD:S000001186","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR143W"}


id: YHR143W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01313":null,"YHR143W-A":null},"has_protein_features":false,"name":"RPC10","ortholog_annotations":[{"gene_uniquename":"YHR143W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01313","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001185","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR143W-A"}


id: YHR144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03771":null,"YHR144C":null},"has_protein_features":false,"name":"DCD1","ortholog_annotations":[{"gene_uniquename":"YHR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03771","reference_uniquename":"PMID:29761456"}],"product":"Deoxycytidine monophosphate (dCMP) deaminase; involved in dUMP and dTMP biosynthesis; expression is NOT cell cycle regulated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001187","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR144C"}


id: YHR145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001188","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR145C"}


id: YHR146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CRP1","product":"Protein that binds to cruciform DNA structures; CRP1 has a paralog, MDG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001189","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR146W"}


id: YHR147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01478":null,"YHR147C":null},"has_protein_features":false,"name":"MRPL6","ortholog_annotations":[{"gene_uniquename":"YHR147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01478","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001190","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR147C"}


id: YHR148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02372":null,"YHR148W":null},"has_protein_features":false,"name":"IMP3","ortholog_annotations":[{"gene_uniquename":"YHR148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02372","reference_uniquename":"PMID:29761456"}],"product":"Component of the SSU processome; SSU processome is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001191","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR148W"}


id: YHR149C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SKG6","product":"Integral membrane protein; localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p; SKG6 has a paralog, TOS2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001192","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR149C"}


id: YHR150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03493":null,"YHR150W":null},"has_protein_features":false,"name":"PEX28","ortholog_annotations":[{"gene_uniquename":"YHR150W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03493","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001193","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR150W"}


id: YHR151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MTC6","product":"Protein of unknown function; mtc6 is synthetically sick with cdc13-1; SWAT-GFP and mCherry fusion proteins localize to the vacuole while SWAT-GFP fusion also localizes to the endoplasmic reticulum","secondary_identifier":"SGD:S000001194","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR151C"}


id: YHR152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01341":null,"YHR152W":null},"has_protein_features":false,"name":"SPO12","ortholog_annotations":[{"gene_uniquename":"YHR152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01341","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein of unknown function; positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis; SPO12 has a paralog, BNS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001195","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR152W"}


id: YHR153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPO16","product":"Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation","secondary_identifier":"SGD:S000001196","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR153C"}


id: YHR154W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02837":null,"SJAG_04142":null,"YHR154W":null},"has_protein_features":false,"name":"RTT107","ortholog_annotations":[{"gene_uniquename":"YHR154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02837","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YHR154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04142","reference_uniquename":"PMID:29761456"}],"product":"BRCA1 C-terminal domain protein needed for recovery from DNA damage; implicated in Mms22-dependent DNA repair during S phase; involved in recruiting SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001197","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR154W"}


id: YHR155W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03247":null,"YHR155W":null},"has_protein_features":false,"name":"LAM1","ortholog_annotations":[{"gene_uniquename":"YHR155W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03247","reference_uniquename":"PMID:29761456"}],"product":"Putative sterol transfer protein; localizes to puncta in the cortical ER; probable role in retrograde transport of sterols from the plasma membrane to the ER; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; contains GRAM, StART-like (VASt) and two PH-like domains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001198","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR155W"}


id: YHR156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00278":null,"YHR156C":null},"has_protein_features":false,"name":"LIN1","ortholog_annotations":[{"gene_uniquename":"YHR156C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00278","reference_uniquename":"PMID:29761456"}],"product":"Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001199","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR156C"}


id: YHR157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"REC104","product":"Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination","secondary_identifier":"SGD:S000001200","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR157W"}


id: YHR158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01196":null,"SJAG_04322":null,"YHR158C":null},"has_protein_features":false,"name":"KEL1","ortholog_annotations":[{"gene_uniquename":"YHR158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01196","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04322","reference_uniquename":"PMID:29761456"}],"product":"Protein required for proper cell fusion and cell morphology; forms a complex with Bud14p and Kel2p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001201","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR158C"}


id: YHR159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TDA11","product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele","secondary_identifier":"SGD:S000001202","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR159W"}


id: YHR160C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEX18","product":"Peroxin; required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p; primarily responsible for peroxisomal import during growth on oleate, and expression is induced during oleate growth","secondary_identifier":"SGD:S000001203","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR160C"}


id: YHR161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01748":null,"YHR161C":null},"has_protein_features":false,"name":"YAP1801","ortholog_annotations":[{"gene_uniquename":"YHR161C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01748","reference_uniquename":"PMID:29761456"}],"product":"Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001204","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR161C"}


id: YHR162W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04593":null,"YHR162W":null},"has_protein_features":false,"name":"MPC2","ortholog_annotations":[{"gene_uniquename":"YHR162W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04593","reference_uniquename":"PMID:29761456"}],"product":"Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on fermentable carbon sources, and heterodimerizes with Mpc1p to form the fermentative isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC2 paralog, MPC3, heterodimerizes with Mpc1p to form the respiratory MPC isoform","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001205","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR162W"}


id: YHR163W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01824":null,"YHR163W":null},"has_protein_features":false,"name":"SOL3","ortholog_annotations":[{"gene_uniquename":"YHR163W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01824","reference_uniquename":"PMID:29761456"}],"product":"6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001206","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR163W"}


id: YHR164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04183":null,"YHR164C":null},"has_protein_features":false,"name":"DNA2","ortholog_annotations":[{"gene_uniquename":"YHR164C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04183","reference_uniquename":"PMID:29761456"}],"product":"ATP-dependent 5'-flap endonuclease and DNA helicase; tracking protein for flap cleavage during Okazaki fragment maturation; involved in DNA repair/processing of meiotic DNA double strand breaks; cell cycle-dependent localization to telomeric chromatin and replicating chromosomes; required for telomerase-dependent telomere synthesis; stability, localization and nuclease activity regulated by sumoylation; forms nuclear foci upon replication stress; human homolog DNA2 complements yeast dna2 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001207","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR164C"}


id: YHR165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04497":null,"YHR165C":null},"has_protein_features":false,"name":"PRP8","ortholog_annotations":[{"gene_uniquename":"YHR165C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04497","reference_uniquename":"PMID:29761456"}],"product":"Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; mouse ortholog interacts with androgen receptor and may have a role in prostate cancer","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001208","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR165C"}


id: YHR165W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps ORF PRP8/YHR165C","secondary_identifier":"SGD:S000028783","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR165W-A"}


id: YHR166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03351":null,"YHR166C":null},"has_protein_features":false,"name":"CDC23","ortholog_annotations":[{"gene_uniquename":"YHR166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03351","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001209","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR166C"}


id: YHR167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"THP2","product":"Subunit of the THO and TREX complexes; THO connects transcription elongation and mitotic recombination, and TREX is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance","secondary_identifier":"SGD:S000001210","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR167W"}


id: YHR168W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00231":null,"YHR168W":null},"has_protein_features":false,"name":"MTG2","ortholog_annotations":[{"gene_uniquename":"YHR168W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00231","reference_uniquename":"PMID:29761456"}],"product":"Putative GTPase; member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001211","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR168W"}


id: YHR169W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01182":null,"YHR169W":null},"has_protein_features":false,"name":"DBP8","ortholog_annotations":[{"gene_uniquename":"YHR169W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01182","reference_uniquename":"PMID:29761456"}],"product":"ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001212","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR169W"}


id: YHR170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03882":null,"YHR170W":null},"has_protein_features":false,"name":"NMD3","ortholog_annotations":[{"gene_uniquename":"YHR170W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03882","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001213","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR170W"}


id: YHR171W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00645":null,"YHR171W":null},"has_protein_features":false,"name":"ATG7","ortholog_annotations":[{"gene_uniquename":"YHR171W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00645","reference_uniquename":"PMID:29761456"}],"product":"Autophagy-related protein and dual specificity member of the E1 family; mediates the attachment of Atg12p to Atg5p and Atg8p to phosphatidylethanolamine which are required steps in autophagosome formation; E1 enzymes are also known as ubiquitin-activating enzymes; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001214","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR171W"}


id: YHR172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03835":null,"YHR172W":null},"has_protein_features":false,"name":"SPC97","ortholog_annotations":[{"gene_uniquename":"YHR172W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03835","reference_uniquename":"PMID:29761456"}],"product":"Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001215","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR172W"}


id: YHR173C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels; SWAT-GFP and mCherry fusion proteins localize to the vacuole","secondary_identifier":"SGD:S000001216","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR173C"}


id: YHR174W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00461":null,"SJAG_02107":null,"SJAG_02369":null,"YHR174W":null},"has_protein_features":false,"name":"ENO2","ortholog_annotations":[{"gene_uniquename":"YHR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00461","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02107","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02369","reference_uniquename":"PMID:29761456"}],"product":"Enolase II, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression induced in response to glucose; ENO2 has a paralog, ENO1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001217","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR174W"}


id: YHR175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CTR2","product":"Low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation; regulated by nonsense-mediated mRNA decay pathway","secondary_identifier":"SGD:S000001218","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR175W"}


id: YHR175W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028553","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR175W-A"}


id: YHR176W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04608":null,"YHR176W":null},"has_protein_features":false,"name":"FMO1","ortholog_annotations":[{"gene_uniquename":"YHR176W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04608","reference_uniquename":"PMID:29761456"}],"product":"Flavin-containing monooxygenase; localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001219","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR176W"}


id: YHR177W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02921":null,"SJAG_04920":null,"YHR177W":null},"has_protein_features":false,"name":"ROF1","ortholog_annotations":[{"gene_uniquename":"YHR177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02921","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04920","reference_uniquename":"PMID:29761456"}],"product":"Putative transcription factor containing a WOPR domain; binds DNA in vitro; similar to C. albicans Wor1p transcription factor that regulates white-opaque switching; overexpression causes a cell cycle delay or arrest","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001220","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR177W"}


id: YHR178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"STB5","product":"Transcription factor; involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro","secondary_identifier":"SGD:S000001221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR178W"}


id: YHR179W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OYE2","product":"Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000001222","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR179W"}


id: YHR180C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YHR180W-A","secondary_identifier":"SGD:S000028554","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR180C-B"}


id: YHR180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000001223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR180W"}


id: YHR180W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3","secondary_identifier":"SGD:S000028555","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR180W-A"}


id: YHR181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00785":null,"YHR181W":null},"has_protein_features":false,"name":"SVP26","ortholog_annotations":[{"gene_uniquename":"YHR181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00785","reference_uniquename":"PMID:29761456"}],"product":"ER exit adaptor for Golgi mannosyltransferases; facilitates the exit of Kre2p, Ktr1p and Mnn4p from the ER; involved in COPII-coated vesicle cargo loading and transport; may also promote the retention of proteins in the early Golgi compartment; integral membrane protein of early Golgi and ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR181W"}


id: YHR182C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF GND1/YHR183W","secondary_identifier":"SGD:S000028784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR182C-A"}


id: YHR182W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RGD3","product":"GTPase activating protein (GAP) for Rho3p, involved in cell polarity green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000001225","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR182W"}


id: YHR183W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03852":null,"YHR183W":null},"has_protein_features":false,"name":"GND1","ortholog_annotations":[{"gene_uniquename":"YHR183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03852","reference_uniquename":"PMID:29761456"}],"product":"6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001226","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR183W"}


id: YHR184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SSP1","product":"Protein involved in the control of meiotic nuclear division; involved in the coordination of meiosis with spore formation; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; required for assembly of the leading edge coat and both prospore membrane shaping and organization; transcription is induced midway through meiosis","secondary_identifier":"SGD:S000001227","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR184W"}


id: YHR185C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PFS1","product":"Sporulation protein required for prospore membrane formation; required for prospore membrane formation at selected spindle poles; ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation","secondary_identifier":"SGD:S000001228","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR185C"}


id: YHR186C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01509":null,"YHR186C":null},"has_protein_features":false,"name":"KOG1","ortholog_annotations":[{"gene_uniquename":"YHR186C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01509","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TORC1; TORC1 is a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001229","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR186C"}


id: YHR187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04175":null,"YHR187W":null},"has_protein_features":false,"name":"IKI1","ortholog_annotations":[{"gene_uniquename":"YHR187W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04175","reference_uniquename":"PMID:29761456"}],"product":"Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR187W"}


id: YHR188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00846":null,"YHR188C":null},"has_protein_features":false,"name":"GPI16","ortholog_annotations":[{"gene_uniquename":"YHR188C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00846","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the glycosylphosphatidylinositol transamidase complex; involved in the addition of GPIs to newly synthesized proteins; luminally-oriented, type I integral membrane glycoprotein of the ER; human PIG-T homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR188C"}


id: YHR189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00936":null,"YHR189W":null},"has_protein_features":false,"name":"PTH1","ortholog_annotations":[{"gene_uniquename":"YHR189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00936","reference_uniquename":"PMID:29761456"}],"product":"One of two mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium; see also PTH2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR189W"}


id: YHR190W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02719":null,"YHR190W":null},"has_protein_features":false,"name":"ERG9","ortholog_annotations":[{"gene_uniquename":"YHR190W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02719","reference_uniquename":"PMID:29761456"}],"product":"Farnesyl-diphosphate farnesyl transferase (squalene synthase); joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR190W"}


id: YHR191C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02373":null,"YHR191C":null},"has_protein_features":false,"name":"CTF8","ortholog_annotations":[{"gene_uniquename":"YHR191C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02373","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a complex with Ctf18p; shares some subunits with Replication Factor C; required for sister chromatid cohesion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR191C"}


id: YHR192W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03812":null,"YHR192W":null},"has_protein_features":false,"name":"LNP1","ortholog_annotations":[{"gene_uniquename":"YHR192W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03812","reference_uniquename":"PMID:29761456"}],"product":"Lunapark family member involved in ER network formation; regulates the ER asymmetry-induced inheritance block during ER stress; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; required for reticulophagy where it is proposed to stabilize the actin-dependent remodeling of the ER; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR192W"}


id: YHR193C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01641":null,"YHR193C":null},"has_protein_features":false,"name":"EGD2","ortholog_annotations":[{"gene_uniquename":"YHR193C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01641","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of the nascent polypeptide-associated complex (NAC); involved in protein sorting and translocation; associated with cytoplasmic ribosomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR193C"}


id: YHR193C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified ORF MDM31/YHR194W","secondary_identifier":"SGD:S000028785","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR193C-A"}


id: YHR194W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03395":null,"YHR194W":null},"has_protein_features":false,"name":"MDM31","ortholog_annotations":[{"gene_uniquename":"YHR194W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03395","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR194W"}


id: YHR195W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NVJ1","product":"Nuclear envelope protein; anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)","secondary_identifier":"SGD:S000001238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR195W"}


id: YHR196W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02499":null,"SJAG_02702":null,"YHR196W":null},"has_protein_features":false,"name":"UTP9","ortholog_annotations":[{"gene_uniquename":"YHR196W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02499","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR196W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02702","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR196W"}


id: YHR197W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01056":null,"YHR197W":null},"has_protein_features":false,"name":"RIX1","ortholog_annotations":[{"gene_uniquename":"YHR197W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01056","reference_uniquename":"PMID:29761456"}],"product":"Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR197W"}


id: YHR198C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AIM18","product":"Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss","secondary_identifier":"SGD:S000001241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR198C"}


id: YHR199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AIM46","product":"Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss","secondary_identifier":"SGD:S000001242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR199C"}


id: YHR199C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00697":null,"YHR199C-A":null},"has_protein_features":false,"name":"NBL1","ortholog_annotations":[{"gene_uniquename":"YHR199C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00697","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the conserved chromosomal passenger complex (CPC); complex regulates mitotic chromosome segregation; not required for the kinase activity of the complex; mediates the interaction of Sli15p and Bir1p; other complex members are Ipl1p, Sli15p, and Bir1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000029704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR199C-A"}


id: YHR200W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02992":null,"YHR200W":null},"has_protein_features":false,"name":"RPN10","ortholog_annotations":[{"gene_uniquename":"YHR200W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02992","reference_uniquename":"PMID:29761456"}],"product":"Proteasome polyubiquitin receptor; non-ATPase subunit of the 19S regulatory particle (RP) of the 26S proteasome that links the RP base to the lid; N-terminus plays a role in the assembly of the regulatory particle (RP); ubiquitin-interacting motif selectively binds to polyubiquitin chains; homolog of the mammalian S5a protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR200W"}


id: YHR201C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03964":null,"YHR201C":null},"has_protein_features":false,"name":"PPX1","ortholog_annotations":[{"gene_uniquename":"YHR201C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03964","reference_uniquename":"PMID:29761456"}],"product":"Exopolyphosphatase; hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR201C"}


id: YHR202W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02580":null,"SJAG_02582":null,"SJAG_02959":null,"YHR202W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHR202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02580","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02582","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02959","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR202W"}


id: YHR203C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04324":null,"SJAG_04663":null,"YHR203C":null},"has_protein_features":false,"name":"RPS4B","ortholog_annotations":[{"gene_uniquename":"YHR203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04324","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04663","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR203C"}


id: YHR204W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01858":null,"YHR204W":null},"has_protein_features":false,"name":"MNL1","ortholog_annotations":[{"gene_uniquename":"YHR204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01858","reference_uniquename":"PMID:29761456"}],"product":"Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; involved in glycan trimming of both folded and misfolded glycoproteins; complexes with Pdi1p, and trims a mannose from Man8GlcNac2 glycans to generate Man7GlcNac2, an oligosaccharide signal on glycoproteins destined for ER-associated protein degradation; requires Pdi1p for stability and substrate recognition; human homolog EDEM1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR204W"}


id: YHR205W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02426":null,"SJAG_04394":null,"YHR205W":null},"has_protein_features":false,"name":"SCH9","ortholog_annotations":[{"gene_uniquename":"YHR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02426","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04394","reference_uniquename":"PMID:29761456"}],"product":"AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR205W"}


id: YHR206W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02472":null,"SJAG_04388":null,"YHR206W":null},"has_protein_features":false,"name":"SKN7","ortholog_annotations":[{"gene_uniquename":"YHR206W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02472","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR206W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04388","reference_uniquename":"PMID:29761456"}],"product":"Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; relocalizes to the cytosol in response to hypoxia; SKN7 has a paralog, HMS2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR206W"}


id: YHR207C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03630":null,"YHR207C":null},"has_protein_features":false,"name":"SET5","ortholog_annotations":[{"gene_uniquename":"YHR207C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03630","reference_uniquename":"PMID:29761456"}],"product":"Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR207C"}


id: YHR208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04149":null,"YHR208W":null},"has_protein_features":false,"name":"BAT1","ortholog_annotations":[{"gene_uniquename":"YHR208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04149","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA biosynthesis; homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase; BAT1 has a paralog, BAT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR208W"}


id: YHR209W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02973":null,"YHR209W":null},"has_protein_features":false,"name":"CRG1","ortholog_annotations":[{"gene_uniquename":"YHR209W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02973","reference_uniquename":"PMID:29761456"}],"product":"S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR209W"}


id: YHR210C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions","secondary_identifier":"SGD:S000001253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR210C"}


id: YHR211W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FLO5","product":"Lectin-like cell wall protein (flocculin) involved in flocculation; binds mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; important for co-flocculation with other yeasts, mediating interaction with specific species; FLO5 has a paralog, FLO1, that arose from a segmental duplication","secondary_identifier":"SGD:S000001254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR211W"}


id: YHR212C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YHR212C has a paralog, YAR060C, that arose from a segmental duplication","secondary_identifier":"SGD:S000001255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR212C"}


id: YHR212W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Pseudogenic fragment with similarity to flocculins; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YHR212W-A has a paralog, YAR061W, that arose from a segmental duplication","secondary_identifier":"SGD:S000028650","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR212W-A"}


id: YHR213W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Pseudogenic fragment with similarity to flocculins; YHR213W has a paralog, YAR062W, that arose from a segmental duplication","secondary_identifier":"SGD:S000001256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR213W"}


id: YHR213W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR213W-A"}


id: YHR213W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Pseudogenic fragment with similarity to flocculins; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; YHR213W-B has a paralog, YAR064W, that arose from a segmental duplication","secondary_identifier":"SGD:S000028652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR213W-B"}


id: YHR214C-D
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP and mCherry fusion proteins localize to the nucleus and endoplasmic reticulum respectively; YHR214C-D has a paralog, YAR069C, that arose from a segmental duplication","secondary_identifier":"SGD:S000028653","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR214C-D"}


id: YHR214C-E
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028654","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR214C-E"}


id: YHR214W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; predicted to be a glycosylphosphatidylinositol-modified (GPI) protein; YHR214W has a paralog, YAR066W, that arose from a segmental duplication","secondary_identifier":"SGD:S000001257","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR214W"}


id: YHR214W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; induced by zinc deficiency; YHR214W-A has a paralog, YAR068W, that arose from a segmental duplication","secondary_identifier":"SGD:S000003535","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR214W-A"}


id: YHR215W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01970":null,"SJAG_04067":null,"YHR215W":null},"has_protein_features":false,"name":"PHO12","ortholog_annotations":[{"gene_uniquename":"YHR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01970","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04067","reference_uniquename":"PMID:29761456"}],"product":"One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog, PHO11, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001258","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR215W"}


id: YHR216W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01298":null,"YHR216W":null},"has_protein_features":false,"name":"IMD2","ortholog_annotations":[{"gene_uniquename":"YHR216W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01298","reference_uniquename":"PMID:29761456"}],"product":"Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation; IMD2 has a paralog, YAR073W/YAR075W, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001259","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR216W"}


id: YHR217C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R","secondary_identifier":"SGD:S000001260","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR217C"}


id: YHR218W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Helicase-like protein encoded within the telomeric Y' element","secondary_identifier":"SGD:S000001261","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR218W"}


id: YHR218W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely within telomere TEL08L","secondary_identifier":"SGD:S000028786","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR218W-A"}


id: YHR219C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR219C-A"}


id: YHR219W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function with similarity to helicases; located in the telomere region on the right arm of chromosome VIII","secondary_identifier":"SGD:S000001262","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR219W"}


id: YIL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02041":null,"YIL001W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YIL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02041","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001263","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL001W"}


id: YIL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04545":null,"YIL002C":null},"has_protein_features":false,"name":"INP51","ortholog_annotations":[{"gene_uniquename":"YIL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04545","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001264","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL002C"}


id: YIL002W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CMI7","product":"Putative mitochondrial protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028835","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL002W-A"}


id: YIL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02895":null,"YIL003W":null},"has_protein_features":false,"name":"CFD1","ortholog_annotations":[{"gene_uniquename":"YIL003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02895","reference_uniquename":"PMID:29761456"}],"product":"Highly conserved iron-sulfur cluster binding protein; localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001265","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL003W"}


id: YIL004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02103":null,"YIL004C":null},"has_protein_features":false,"name":"BET1","ortholog_annotations":[{"gene_uniquename":"YIL004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02103","reference_uniquename":"PMID:29761456"}],"product":"Type II membrane protein required for vesicular transport; required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001266","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL004C"}


id: YIL005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00131":null,"SJAG_02301":null,"SJAG_04904":null,"YIL005W":null},"has_protein_features":false,"name":"EPS1","ortholog_annotations":[{"gene_uniquename":"YIL005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00131","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02301","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04904","reference_uniquename":"PMID:29761456"}],"product":"ER protein with chaperone and co-chaperone activity; involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001267","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL005W"}


id: YIL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04328":null,"YIL006W":null},"has_protein_features":false,"name":"YIA6","ortholog_annotations":[{"gene_uniquename":"YIL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04328","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial NAD+ transporter; involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs; YIA6 has a paralog, YEA6, that arose from the whole genome duplication; human NAD+ transporter MCART1/SLC25A51 functionally complements the yia6 yea6 double null mutant, and yeast YIA6 reciprocally complements defects in MCART1/SLC25A51 null cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001268","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL006W"}


id: YIL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02570":null,"YIL007C":null},"has_protein_features":false,"name":"NAS2","ortholog_annotations":[{"gene_uniquename":"YIL007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02570","reference_uniquename":"PMID:29761456"}],"product":"Evolutionarily conserved 19S regulatory particle assembly-chaperone; involved in assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress; ortholog of human p27","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001269","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL007C"}


id: YIL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03616":null,"YIL008W":null},"has_protein_features":false,"name":"URM1","ortholog_annotations":[{"gene_uniquename":"YIL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03616","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001270","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL008W"}


id: YIL009C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01378":null,"YIL009C-A":null},"has_protein_features":false,"name":"EST3","ortholog_annotations":[{"gene_uniquename":"YIL009C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01378","reference_uniquename":"PMID:29761456"}],"product":"Component of the telomerase holoenzyme; involved in telomere replication; synthesis of the full-length protein results from a programmed +1 ribosomal frameshift","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006432","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL009C-A"}


id: YIL009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03471":null,"SJAG_03909":null,"YIL009W":null},"has_protein_features":false,"name":"FAA3","ortholog_annotations":[{"gene_uniquename":"YIL009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03471","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03909","reference_uniquename":"PMID:29761456"}],"product":"Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C16:0-C18:0 chain lengths; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001271","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL009W"}


id: YIL010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02515":null,"YIL010W":null},"has_protein_features":false,"name":"DOT5","ortholog_annotations":[{"gene_uniquename":"YIL010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02515","reference_uniquename":"PMID:29761456"}],"product":"Nuclear thiol peroxidase; functions as an alkyl-hydroperoxide reductase during post-diauxic growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001272","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL010W"}


id: YIL011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TIR3","product":"Cell wall mannoprotein; member of Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; TIR3 has a paralog, TIR2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001273","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL011W"}


id: YIL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000001274","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL012W"}


id: YIL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04277":null,"YIL013C":null},"has_protein_features":false,"name":"PDR11","ortholog_annotations":[{"gene_uniquename":"YIL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"ATP-binding cassette (ABC) transporter; multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth; PDR11 has a paralog, AUS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001275","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL013C"}


id: YIL014C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000003536","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL014C-A"}


id: YIL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MNT3","product":"Alpha-1,3-mannosyltransferase; adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation","secondary_identifier":"SGD:S000001276","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL014W"}


id: YIL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BAR1","product":"Aspartyl protease secreted to periplasmic space of mating type a cell; helps cells monitor availability of mating partners; cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest","secondary_identifier":"SGD:S000001277","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL015W"}


id: YIL016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01737":null,"SJAG_04817":null,"YIL016W":null},"has_protein_features":false,"name":"SNL1","ortholog_annotations":[{"gene_uniquename":"YIL016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01737","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04817","reference_uniquename":"PMID:29761456"}],"product":"Ribosome-associated protein; proposed to act in protein synthesis, nuclear pore complex biogenesis and maintenance as well as protein folding and prion maintenance; ; has similarity to the mammalian BAG-1 protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001278","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL016W"}


id: YIL017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02197":null,"YIL017C":null},"has_protein_features":false,"name":"VID28","ortholog_annotations":[{"gene_uniquename":"YIL017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02197","reference_uniquename":"PMID:29761456"}],"product":"GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001279","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL017C"}


id: YIL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00034":null,"SJAG_02312":null,"YIL018W":null},"has_protein_features":false,"name":"RPL2B","ortholog_annotations":[{"gene_uniquename":"YIL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02312","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001280","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL018W"}


id: YIL019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01347":null,"YIL019W":null},"has_protein_features":false,"name":"FAF1","ortholog_annotations":[{"gene_uniquename":"YIL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01347","reference_uniquename":"PMID:29761456"}],"product":"Protein required for pre-rRNA processing; also required for 40S ribosomal subunit assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001281","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL019W"}


id: YIL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01346":null,"YIL020C":null},"has_protein_features":false,"name":"HIS6","ortholog_annotations":[{"gene_uniquename":"YIL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01346","reference_uniquename":"PMID:29761456"}],"product":"Enzyme that catalyzes the fourth step in the histidine pathway; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001282","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL020C"}


id: YIL020C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps origin of replication ARS918, partially overlaps ORF RPB3/YIL021W","secondary_identifier":"SGD:S000028787","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL020C-A"}


id: YIL021C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene RPB3/YIL021W; identified by gene-trapping, expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL021C-A"}


id: YIL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02506":null,"YIL021W":null},"has_protein_features":false,"name":"RPB3","ortholog_annotations":[{"gene_uniquename":"YIL021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02506","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001283","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL021W"}


id: YIL022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02077":null,"YIL022W":null},"has_protein_features":false,"name":"TIM44","ortholog_annotations":[{"gene_uniquename":"YIL022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02077","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the TIM23 complex; tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex); TIM23 complex is short for the translocase of the inner mitochondrial membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001284","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL022W"}


id: YIL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00222":null,"YIL023C":null},"has_protein_features":false,"name":"YKE4","ortholog_annotations":[{"gene_uniquename":"YIL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00222","reference_uniquename":"PMID:29761456"}],"product":"Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001285","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL023C"}


id: YIL024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p","secondary_identifier":"SGD:S000001286","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL024C"}


id: YIL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001287","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL025C"}


id: YIL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03418":null,"SJAG_03698":null,"YIL026C":null},"has_protein_features":false,"name":"IRR1","ortholog_annotations":[{"gene_uniquename":"YIL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03418","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03698","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the cohesin complex; which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms; relocalizes to the cytosol in response to hypoxia; essential for viability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001288","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL026C"}


id: YIL027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01223":null,"YIL027C":null},"has_protein_features":false,"name":"EMC5","ortholog_annotations":[{"gene_uniquename":"YIL027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01223","reference_uniquename":"PMID:29761456"}],"product":"Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001289","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL027C"}


id: YIL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001290","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL028W"}


id: YIL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"EMA17","product":"Protein involved in targeting mitochondrial membrane protein precursors to mitochondrial translocation system; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has a paralog, YPR071W, that arose from a single-locus duplication","secondary_identifier":"SGD:S000001291","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL029C"}


id: YIL029W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF SSM4/YIL030C","secondary_identifier":"SGD:S000028788","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL029W-A"}


id: YIL030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03657":null,"YIL030C":null},"has_protein_features":false,"name":"SSM4","ortholog_annotations":[{"gene_uniquename":"YIL030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03657","reference_uniquename":"PMID:29761456"}],"product":"Membrane-embedded ubiquitin-protein ligase and retrotranslocase; ER and inner nuclear membrane localized RING-CH domain E3 ligase involved in ER-associated protein degradation (ERAD); aids Cdc48p in the extraction of faulty membrane proteins; targets misfolded cytosolic/nucleoplasmic domains of soluble and membrane embedded proteins (ERAD-C) and Sbh2p, a transmembrane domain-containing substrate (ERAD-M); C-terminal element, conserved in human ortholog MARCH6, determines substrate selectivity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001292","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL030C"}


id: YIL030W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF ULP2/YIL031W","secondary_identifier":"SGD:S000028789","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL030W-A"}


id: YIL031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_16454":null,"YIL031W":null},"has_protein_features":false,"name":"ULP2","ortholog_annotations":[{"gene_uniquename":"YIL031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16454","reference_uniquename":"PMID:29761456"}],"product":"Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins; plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate; human homolog PML implicated in promyelocytic leukemia can partially complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001293","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL031W"}


id: YIL032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001294","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL032C"}


id: YIL033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01245":null,"YIL033C":null},"has_protein_features":false,"name":"BCY1","ortholog_annotations":[{"gene_uniquename":"YIL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01245","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA); PKA is a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001295","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL033C"}


id: YIL034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02700":null,"YIL034C":null},"has_protein_features":false,"name":"CAP2","ortholog_annotations":[{"gene_uniquename":"YIL034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02700","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001296","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL034C"}


id: YIL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01799":null,"YIL035C":null},"has_protein_features":false,"name":"CKA1","ortholog_annotations":[{"gene_uniquename":"YIL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01799","reference_uniquename":"PMID:29761456"}],"product":"Alpha catalytic subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001297","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL035C"}


id: YIL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CST6","product":"Basic leucine zipper (bZIP) transcription factor from ATF/CREB family involved in stress-responsive regulatory network; mediates transcriptional activation of NCE103 in response to low CO2 levels; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; relocalizes to the cytosol in response to hypoxia; CST6 has a paralog, ACA1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001298","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL036W"}


id: YIL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PRM2","product":"Pheromone-regulated protein; predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion","secondary_identifier":"SGD:S000001299","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL037C"}


id: YIL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04350":null,"YIL038C":null},"has_protein_features":false,"name":"NOT3","ortholog_annotations":[{"gene_uniquename":"YIL038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04350","reference_uniquename":"PMID:29761456"}],"product":"Component of the CCR4-NOT core complex, involved in mRNA decapping; involved in transcription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not3p and Not5p is mutated in cancers","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001300","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL038C"}


id: YIL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01860":null,"YIL039W":null},"has_protein_features":false,"name":"TED1","ortholog_annotations":[{"gene_uniquename":"YIL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01860","reference_uniquename":"PMID:29761456"}],"product":"GPI-glycan remodelase; conserved phosphoesterase domain-containing protein; acts together with Emp24p/Erv25p in cargo exit from the ER; functional ortholog of mammalian GPI-glycan remodelase PGAP5; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001301","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL039W"}


id: YIL040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04578":null,"YIL040W":null},"has_protein_features":false,"name":"APQ12","ortholog_annotations":[{"gene_uniquename":"YIL040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04578","reference_uniquename":"PMID:29761456"}],"product":"Nuclear envelope/ER integral membrane protein; interacts and functions with Brr6p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA export from the nucleus and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001302","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL040W"}


id: YIL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GVP36","product":"BAR domain protein that localizes to early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis","secondary_identifier":"SGD:S000001303","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL041W"}


id: YIL042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01402":null,"YIL042C":null},"has_protein_features":false,"name":"PKP1","ortholog_annotations":[{"gene_uniquename":"YIL042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01402","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein kinase; involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001304","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL042C"}


id: YIL043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00235":null,"YIL043C":null},"has_protein_features":false,"name":"CBR1","ortholog_annotations":[{"gene_uniquename":"YIL043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00235","reference_uniquename":"PMID:29761456"}],"product":"Cytochrome b reductase and NADH-dependent reductase for Dph3p; required for diphthamide synthesis and tRNA wobble uridine modification; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001305","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL043C"}


id: YIL044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01600":null,"SJAG_04724":null,"YIL044C":null},"has_protein_features":false,"name":"AGE2","ortholog_annotations":[{"gene_uniquename":"YIL044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01600","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04724","reference_uniquename":"PMID:26896847"}],"product":"ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001306","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL044C"}


id: YIL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PIG2","product":"Putative type-1 protein phosphatase targeting subunit; tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase; PIG2 has a paralog, GIP2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001307","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL045W"}


id: YIL046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00192":null,"YIL046W":null},"has_protein_features":false,"name":"MET30","ortholog_annotations":[{"gene_uniquename":"YIL046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00192","reference_uniquename":"PMID:29761456"}],"product":"F-box protein containing five copies of the WD40 motif; controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus; dissociation of Met30p from SCF complex in response to cadmium stress is regulated by Cdc48p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001308","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL046W"}


id: YIL046W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028836","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL046W-A"}


id: YIL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00233":null,"YIL047C":null},"has_protein_features":false,"name":"SYG1","ortholog_annotations":[{"gene_uniquename":"YIL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00233","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001309","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL047C"}


id: YIL047C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF SYG1/YIL047C","secondary_identifier":"SGD:S000028790","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL047C-A"}


id: YIL048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05209":null,"YIL048W":null},"has_protein_features":false,"name":"NEO1","ortholog_annotations":[{"gene_uniquename":"YIL048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05209","reference_uniquename":"PMID:29761456"}],"product":"Phospholipid translocase (flippase); involved in generating phospholipid asymmetry in the plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi-to-ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001310","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL048W"}


id: YIL049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04954":null,"YIL049W":null},"has_protein_features":false,"name":"DFG10","ortholog_annotations":[{"gene_uniquename":"YIL049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04954","reference_uniquename":"PMID:29761456"}],"product":"Probable polyprenol reductase; catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; involved in filamentous growth; mutations in human homolog SRD5A3 confer CDG (Congenital Disorders of Glycosylation); human SRD5A3 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001311","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL049W"}


id: YIL050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05978":null,"YIL050W":null},"has_protein_features":false,"name":"PCL7","ortholog_annotations":[{"gene_uniquename":"YIL050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05978","reference_uniquename":"PMID:29761456"}],"product":"Pho85p cyclin of the Pho80p subfamily; forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated; PCL7 has a paralog, PCL6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001312","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL050W"}


id: YIL051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00107":null,"YIL051C":null},"has_protein_features":false,"name":"MMF1","ortholog_annotations":[{"gene_uniquename":"YIL051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00107","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for transamination of isoleucine; but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; induction of expression in response to stress is mediated by a Hog1p-regulated antisense RNA and gene looping; interacts genetically with mitochondrial ribosomal protein genes; MMF1 has a paralog, HMF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001313","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL051C"}


id: YIL052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01853":null,"SJAG_05216":null,"YIL052C":null},"has_protein_features":false,"name":"RPL34B","ortholog_annotations":[{"gene_uniquename":"YIL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01853","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05216","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001314","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL052C"}


id: YIL053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GPP1","product":"Constitutively expressed DL-glycerol-3-phosphate phosphatase; also known as glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; GPP1 has a paralog, GPP2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001315","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL053W"}


id: YIL054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels","secondary_identifier":"SGD:S000001316","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL054W"}


id: YIL055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001317","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL055C"}


id: YIL056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"VHR1","product":"Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001318","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL056W"}


id: YIL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RGI2","product":"Protein of unknown function; involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose; RGI2 has a paralog, RGI1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001319","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL057C"}


id: YIL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001320","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL058W"}


id: YIL059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W","secondary_identifier":"SGD:S000001321","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL059C"}


id: YIL060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Mitochondrial protein of unknown function; required for respiratory growth; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene","secondary_identifier":"SGD:S000001322","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL060W"}


id: YIL061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05009":null,"YIL061C":null},"has_protein_features":false,"name":"SNP1","ortholog_annotations":[{"gene_uniquename":"YIL061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05009","reference_uniquename":"PMID:29761456"}],"product":"Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001323","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL061C"}


id: YIL062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04100":null,"YIL062C":null},"has_protein_features":false,"name":"ARC15","ortholog_annotations":[{"gene_uniquename":"YIL062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04100","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001324","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL062C"}


id: YIL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03836":null,"YIL063C":null},"has_protein_features":false,"name":"YRB2","ortholog_annotations":[{"gene_uniquename":"YIL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03836","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; relocalizes to the cytosol in response to hypoxia; not essential for viability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001325","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL063C"}


id: YIL064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04159":null,"YIL064W":null},"has_protein_features":false,"name":"EFM4","ortholog_annotations":[{"gene_uniquename":"YIL064W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04159","reference_uniquename":"PMID:29761456"}],"product":"Lysine methyltransferase; involved in the dimethylation of eEF1A (Tef1p/Tef2p) at lysine 316; sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001326","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL064W"}


id: YIL065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03464":null,"YIL065C":null},"has_protein_features":false,"name":"FIS1","ortholog_annotations":[{"gene_uniquename":"YIL065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03464","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in mitochondrial fission and peroxisome abundance; may have a distinct role in tethering protein aggregates to mitochondria in order to retain them in the mother cell; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001327","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL065C"}


id: YIL066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04665":null,"YIL066C":null},"has_protein_features":false,"name":"RNR3","ortholog_annotations":[{"gene_uniquename":"YIL066C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04665","reference_uniquename":"PMID:29761456"}],"product":"Minor isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; RNR3 has a paralog, RNR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001328","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL066C"}


id: YIL066W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YIL067C","secondary_identifier":"SGD:S000028791","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL066W-A"}


id: YIL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Uncharacterized protein of unknown function","secondary_identifier":"SGD:S000001329","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL067C"}


id: YIL068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01925":null,"YIL068C":null},"has_protein_features":false,"name":"SEC6","ortholog_annotations":[{"gene_uniquename":"YIL068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01925","reference_uniquename":"PMID:29761456"}],"product":"Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; binds to SNARE complexes binteracting with Sec9p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001330","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL068C"}


id: YIL068W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF SEC6/YIL068C","secondary_identifier":"SGD:S000028792","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL068W-A"}


id: YIL069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00468":null,"SJAG_02585":null,"YIL069C":null},"has_protein_features":false,"name":"RPS24B","ortholog_annotations":[{"gene_uniquename":"YIL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00468","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02585","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001331","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL069C"}


id: YIL070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03104":null,"SJAG_03155":null,"YIL070C":null},"has_protein_features":false,"name":"MAM33","ortholog_annotations":[{"gene_uniquename":"YIL070C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03104","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL070C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03155","reference_uniquename":"PMID:29761456"}],"product":"Acidic protein of the mitochondrial matrix; binds unassembled large subunit proteins during ribosome assembly; subunit of a complex containing Mrx6p, Pim1p, and Pet20p that may regulate mtDNA replication; related to the human complement receptor gC1q-R","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001332","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL070C"}


id: YIL071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PCI8","product":"Possible shared subunit of Cop9 signalosome (CSN) and eIF3; binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain","secondary_identifier":"SGD:S000001333","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL071C"}


id: YIL071W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF PCI8/YIL071C","secondary_identifier":"SGD:S000028793","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL071W-A"}


id: YIL072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02652":null,"YIL072W":null},"has_protein_features":false,"name":"HOP1","ortholog_annotations":[{"gene_uniquename":"YIL072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02652","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein-DNA filaments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001334","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL072W"}


id: YIL073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPO22","product":"Meiosis-specific protein essential for chromosome synapsis; involved in completion of nuclear divisions during meiosis; induced early in meiosis","secondary_identifier":"SGD:S000001335","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL073C"}


id: YIL074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02313":null,"YIL074C":null},"has_protein_features":false,"name":"SER33","ortholog_annotations":[{"gene_uniquename":"YIL074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02313","reference_uniquename":"PMID:29761456"}],"product":"3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; also functions as an alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); localizes to the cytoplasm; SER33 has a paralog, SER3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001336","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL074C"}


id: YIL075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04088":null,"YIL075C":null},"has_protein_features":false,"name":"RPN2","ortholog_annotations":[{"gene_uniquename":"YIL075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04088","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001337","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL075C"}


id: YIL076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02234":null,"YIL076W":null},"has_protein_features":false,"name":"SEC28","ortholog_annotations":[{"gene_uniquename":"YIL076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02234","reference_uniquename":"PMID:29761456"}],"product":"Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001338","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL076W"}


id: YIL077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RCI37","product":"Protein that associates with the large mitoribosomal subunit; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)","secondary_identifier":"SGD:S000001339","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL077C"}


id: YIL078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01235":null,"YIL078W":null},"has_protein_features":false,"name":"THS1","ortholog_annotations":[{"gene_uniquename":"YIL078W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01235","reference_uniquename":"PMID:29761456"}],"product":"Threonyl-tRNA synthetase; essential cytoplasmic protein; human homolog TARS can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001340","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL078W"}


id: YIL079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03984":null,"YIL079C":null},"has_protein_features":false,"name":"AIR1","ortholog_annotations":[{"gene_uniquename":"YIL079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03984","reference_uniquename":"PMID:29761456"}],"product":"Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication; although Air1p and Air2p are homologous TRAMP subunits, they have nonredundant roles in regulation of substrate specificity of the exosome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001341","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL079C"}


id: YIL082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag","secondary_identifier":"SGD:S000001344","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL082W"}


id: YIL083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01139":null,"YIL083C":null},"has_protein_features":false,"name":"CAB2","ortholog_annotations":[{"gene_uniquename":"YIL083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01139","reference_uniquename":"PMID:29761456"}],"product":"Phosphopantothenoylcysteine synthetase (PPCS); catalyzes the second step of coenzyme A biosynthesis from pantothenate; subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) that contains: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p subunits; null mutant lethality is complemented by human homolog PPCS and by E. coli coaBC, a bifunctional enzyme with PPCS activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001345","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL083C"}


id: YIL084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02981":null,"YIL084C":null},"has_protein_features":false,"name":"SDS3","ortholog_annotations":[{"gene_uniquename":"YIL084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02981","reference_uniquename":"PMID:29761456"}],"product":"Component of the Rpd3L histone deacetylase complex; required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; relocalizes to the cytosol in response to hypoxia; cells defective in SDS3 display pleiotropic phenotypes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001346","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL084C"}


id: YIL085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02519":null,"SJAG_03082":null,"YIL085C":null},"has_protein_features":false,"name":"KTR7","ortholog_annotations":[{"gene_uniquename":"YIL085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02519","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03082","reference_uniquename":"PMID:29761456"}],"product":"Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001347","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL085C"}


id: YIL086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000001348","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL086C"}


id: YIL087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01155":null,"YIL087C":null},"has_protein_features":false,"name":"AIM19","ortholog_annotations":[{"gene_uniquename":"YIL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01155","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; mitochondrial protein that physically interacts with Tim23p; null mutant displays reduced respiratory growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001349","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL087C"}


id: YIL088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03256":null,"YIL088C":null},"has_protein_features":false,"name":"AVT7","ortholog_annotations":[{"gene_uniquename":"YIL088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03256","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar amino acid transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001350","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL088C"}


id: YIL089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking","secondary_identifier":"SGD:S000001351","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL089W"}


id: YIL090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02683":null,"YIL090W":null},"has_protein_features":false,"name":"ICE2","ortholog_annotations":[{"gene_uniquename":"YIL090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02683","reference_uniquename":"PMID:29761456"}],"product":"Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; required for post-translational SRP-independent protein translocation into the ER; necessary for efficient targeting of Trm1p tRNA methyltransferase to the inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001352","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL090W"}


id: YIL091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00945":null,"YIL091C":null},"has_protein_features":false,"name":"UTP25","ortholog_annotations":[{"gene_uniquename":"YIL091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00945","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001353","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL091C"}


id: YIL092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus","secondary_identifier":"SGD:S000001354","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL092W"}


id: YIL093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04378":null,"YIL093C":null},"has_protein_features":false,"name":"RSM25","ortholog_annotations":[{"gene_uniquename":"YIL093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04378","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001355","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL093C"}


id: YIL094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00502":null,"YIL094C":null},"has_protein_features":false,"name":"LYS12","ortholog_annotations":[{"gene_uniquename":"YIL094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00502","reference_uniquename":"PMID:29761456"}],"product":"Homo-isocitrate dehydrogenase; an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001356","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL094C"}


id: YIL095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00649":null,"SJAG_04052":null,"SJAG_04465":null,"YIL095W":null},"has_protein_features":false,"name":"PRK1","ortholog_annotations":[{"gene_uniquename":"YIL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00649","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04052","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04465","reference_uniquename":"PMID:29761456"}],"product":"Ser/Thr protein kinase; regulates the organization and function of the actin cytoskeleton; inhibits clathrin-mediated endocytosis; phosphorylates the Pan1p and Sla1p subunits of the Pan1p-Sla1p-End3p complex, resulting in inhibition of complex formation; inhibits Scd5p through phosphorylation; phosphorylates Pan1p-interacting proteins, Ent1/2 and Yap1801/2; negatively regulated through autophosphorylation; functional overlap with ARK1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001357","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL095W"}


id: YIL096C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03008":null,"YIL096C":null},"has_protein_features":false,"name":"BMT5","ortholog_annotations":[{"gene_uniquename":"YIL096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03008","reference_uniquename":"PMID:29761456"}],"product":"Methyltransferase required for m3U2634 methylation of the 25S rRNA; S-adenosylmethionine-dependent; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001358","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL096C"}


id: YIL097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04309":null,"YIL097W":null},"has_protein_features":false,"name":"FYV10","ortholog_annotations":[{"gene_uniquename":"YIL097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04309","reference_uniquename":"PMID:29761456"}],"product":"Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001359","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL097W"}


id: YIL098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_06135":null,"YIL098C":null},"has_protein_features":false,"name":"FMC1","ortholog_annotations":[{"gene_uniquename":"YIL098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06135","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial matrix protein; required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001360","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL098C"}


id: YIL099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02076":null,"YIL099W":null},"has_protein_features":false,"name":"SGA1","ortholog_annotations":[{"gene_uniquename":"YIL099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02076","reference_uniquename":"PMID:29761456"}],"product":"Intracellular sporulation-specific glucoamylase; involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001361","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL099W"}


id: YIL100C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000028794","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL100C-A"}


id: YIL100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A","secondary_identifier":"SGD:S000001362","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL100W"}


id: YIL101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"XBP1","product":"Transcriptional repressor; binds promoter sequences of cyclin genes, CYS3, and SMF2; not expressed during log phase of growth, but induced by stress or starvation during mitosis, and late in meiosis; represses 15% of all yeast genes as cells transition to quiescence; important for maintaining G1 arrest and for longevity of quiescent cells; member of Swi4p/Mbp1p family; phosphorylated by Cdc28p; relative distribution to nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000001363","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL101C"}


id: YIL102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001364","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL102C"}


id: YIL102C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05219":null,"YIL102C-A":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YIL102C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05219","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of dolichyl phosphate mannose (DPM) synthase; identified based on comparisons of the genome sequences of six Saccharomyces species; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000113587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL102C-A"}


id: YIL103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01058":null,"YIL103W":null},"has_protein_features":false,"name":"DPH1","ortholog_annotations":[{"gene_uniquename":"YIL103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01058","reference_uniquename":"PMID:29761456"}],"product":"Protein required for synthesis of diphthamide; required along with Dph2p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); forms a complex with Dph2p that catalyzes the first step of diphthamide biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001365","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL103W"}


id: YIL104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03551":null,"YIL104C":null},"has_protein_features":false,"name":"SHQ1","ortholog_annotations":[{"gene_uniquename":"YIL104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03551","reference_uniquename":"PMID:29761456"}],"product":"Chaperone protein; required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing; functions as an RNA mimic; forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001366","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL104C"}


id: YIL105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02989":null,"YIL105C":null},"has_protein_features":false,"name":"SLM1","ortholog_annotations":[{"gene_uniquename":"YIL105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02989","reference_uniquename":"PMID:29761456"}],"product":"Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; TORC2 complex substrate and effector; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001367","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL105C"}


id: YIL105W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; completely overlaps the verified gene SLM1; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; mRNA identified as translated by ribosome profiling data","secondary_identifier":"SGD:S000028657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL105W-A"}


id: YIL106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03936":null,"YIL106W":null},"has_protein_features":false,"name":"MOB1","ortholog_annotations":[{"gene_uniquename":"YIL106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03936","reference_uniquename":"PMID:29761456"}],"product":"Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001368","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL106W"}


id: YIL107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02596":null,"SJAG_03336":null,"YIL107C":null},"has_protein_features":false,"name":"PFK26","ortholog_annotations":[{"gene_uniquename":"YIL107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02596","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03336","reference_uniquename":"PMID:29761456"}],"product":"6-phosphofructo-2-kinase; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001369","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL107C"}


id: YIL108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03407":null,"YIL108W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YIL108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03407","reference_uniquename":"PMID:29761456"}],"product":"Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001370","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL108W"}


id: YIL109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00072":null,"YIL109C":null},"has_protein_features":false,"name":"SEC24","ortholog_annotations":[{"gene_uniquename":"YIL109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00072","reference_uniquename":"PMID:29761456"}],"product":"Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SEC24 has a paralog, SFB2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001371","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL109C"}


id: YIL110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02868":null,"YIL110W":null},"has_protein_features":false,"name":"HPM1","ortholog_annotations":[{"gene_uniquename":"YIL110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02868","reference_uniquename":"PMID:29761456"}],"product":"AdoMet-dependent methyltransferase; involved in a novel 3-methylhistidine modification of multiple proteins, including ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001372","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL110W"}


id: YIL111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01077":null,"YIL111W":null},"has_protein_features":false,"name":"COX5B","ortholog_annotations":[{"gene_uniquename":"YIL111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01077","reference_uniquename":"PMID:29761456"}],"product":"Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001373","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL111W"}


id: YIL112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HOS4","product":"Subunit of the Set3 complex; complex is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate","secondary_identifier":"SGD:S000001374","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL112W"}


id: YIL113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03263":null,"YIL113W":null},"has_protein_features":false,"name":"SDP1","ortholog_annotations":[{"gene_uniquename":"YIL113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03263","reference_uniquename":"PMID:29761456"}],"product":"Stress-inducible dual-specificity MAP kinase phosphatase; negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock; SDP1 has a paralog, MSG5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001375","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL113W"}


id: YIL114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00048":null,"YIL114C":null},"has_protein_features":false,"name":"POR2","ortholog_annotations":[{"gene_uniquename":"YIL114C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00048","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001376","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL114C"}


id: YIL115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01013":null,"YIL115C":null},"has_protein_features":false,"name":"NUP159","ortholog_annotations":[{"gene_uniquename":"YIL115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01013","reference_uniquename":"PMID:29761456"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001377","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL115C"}


id: YIL115W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUP159/YIL115C","secondary_identifier":"SGD:S000028795","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL115W-A"}


id: YIL116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03055":null,"YIL116W":null},"has_protein_features":false,"name":"HIS5","ortholog_annotations":[{"gene_uniquename":"YIL116W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03055","reference_uniquename":"PMID:29761456"}],"product":"Histidinol-phosphate aminotransferase; catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL116W"}


id: YIL117C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PRM5","product":"Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling; PRM5 has a paralog, YNL058C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL117C"}


id: YIL118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02366":null,"YIL118W":null},"has_protein_features":false,"name":"RHO3","ortholog_annotations":[{"gene_uniquename":"YIL118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02366","reference_uniquename":"PMID:29761456"}],"product":"Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL118W"}


id: YIL119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RPI1","product":"Transcription factor, allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF","secondary_identifier":"SGD:S000001381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL119C"}


id: YIL120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"QDR1","product":"Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in spore wall assembly; sequence similarity to DTR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL120W"}


id: YIL121W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"QDR2","product":"Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper","secondary_identifier":"SGD:S000001383","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL121W"}


id: YIL122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"POG1","product":"DNA-binding transcriptional activator; involved in cell cycle regulation; overexpression promotes recovery from pheromone induced arrest via CLN1/2 transcription, induction of of IME1 during sporulation, and suppression of stress sensitivity resulting from mutation of the E3 ubiquitin ligase Rsp5p; binds upstream of BAR1 and cell cycle-related genes; phosphorylated form may be ubiquitinated by Dma2p; potential Cdc28p substrate; regulated by Swi4/6 cell-cycle box binding factor (SBF)","secondary_identifier":"SGD:S000001384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL122W"}


id: YIL123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02649":null,"SJAG_03295":null,"YIL123W":null},"has_protein_features":false,"name":"SIM1","ortholog_annotations":[{"gene_uniquename":"YIL123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02649","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03295","reference_uniquename":"PMID:29761456"}],"product":"Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p); may participate in DNA replication; promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated; SIM1 has a paralog, SUN4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL123W"}


id: YIL124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01036":null,"YIL124W":null},"has_protein_features":false,"name":"AYR1","ortholog_annotations":[{"gene_uniquename":"YIL124W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01036","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional triacylglycerol lipase and 1-acyl DHAP reductase; NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase involved in phosphatidic acid biosynthesis; lipid droplet triacylglycerol lipase involved in mobilization of non-polar lipids; found in lipid particles, endoplasmic reticulum and mitochondrial outer membrane; forms NADPH-regulated channel in mitochondrial outer membrane; required for spore germination; role in cell wall biosynthesis; capable of metabolizing steroid hormones","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL124W"}


id: YIL125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02464":null,"YIL125W":null},"has_protein_features":false,"name":"KGD1","ortholog_annotations":[{"gene_uniquename":"YIL125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02464","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex; catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL125W"}


id: YIL126W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04755":null,"SJAG_05313":null,"YIL126W":null},"has_protein_features":false,"name":"STH1","ortholog_annotations":[{"gene_uniquename":"YIL126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04755","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05313","reference_uniquename":"PMID:29761456"}],"product":"ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; promotes base excision repair in chromatin; essential helicase-related protein homologous to Snf2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL126W"}


id: YIL127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RRT14","product":"Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis","secondary_identifier":"SGD:S000001389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL127C"}


id: YIL128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02866":null,"YIL128W":null},"has_protein_features":false,"name":"MET18","ortholog_annotations":[{"gene_uniquename":"YIL128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02866","reference_uniquename":"PMID:29761456"}],"product":"Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation and maturation of a subset of cytosolic and nuclear proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL128W"}


id: YIL129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03637":null,"YIL129C":null},"has_protein_features":false,"name":"TAO3","ortholog_annotations":[{"gene_uniquename":"YIL129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03637","reference_uniquename":"PMID:29761456"}],"product":"Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL129C"}


id: YIL130W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05343":null,"YIL130W":null},"has_protein_features":false,"name":"ASG1","ortholog_annotations":[{"gene_uniquename":"YIL130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05343","reference_uniquename":"PMID:29761456"}],"product":"Zinc cluster protein proposed to be a transcriptional regulator; regulator involved in the stress response; regulates utilization of fatty acids and accumulation of lipids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL130W"}


id: YIL131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04813":null,"YIL131C":null},"has_protein_features":false,"name":"FKH1","ortholog_annotations":[{"gene_uniquename":"YIL131C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04813","reference_uniquename":"PMID:29761456"}],"product":"Forkhead family transcription factor; rate-limiting replication origin activator; evolutionarily conserved lifespan regulator; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; regulates transcription elongation, chromatin silencing at mating loci, expression of G2/M phase genes; facilitates clustering, activation of early-firing replication origins; binds HML recombination enhancer, regulates donor preference during mating-type switching","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL131C"}


id: YIL132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CSM2","product":"Subunit of the Shu complex (aka PCSS complex); Shu complex also includes Psy3, Shu1, Shu2, and promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p anti-recombinase function; promotes formation of Rad51p filaments; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis","secondary_identifier":"SGD:S000001394","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL132C"}


id: YIL133C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02207":null,"SJAG_04160":null,"YIL133C":null},"has_protein_features":false,"name":"RPL16A","ortholog_annotations":[{"gene_uniquename":"YIL133C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02207","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL133C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04160","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001395","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL133C"}


id: YIL134C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028556","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL134C-A"}


id: YIL134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03503":null,"YIL134W":null},"has_protein_features":false,"name":"FLX1","ortholog_annotations":[{"gene_uniquename":"YIL134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03503","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial flavin adenine dinucleotide transporter; FAD is a synthesis product of riboflavin; human homolog SLC25A32 is implicated in multiple acyl-CoA dehydrogenase deficiency (MADD) or glutaric aciduria type II (GAII), and can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001396","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL134W"}


id: YIL135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"VHS2","product":"Regulator of septin dynamics; involved in the regulation of septin dynamics at bud neck after mitotic entry, likely by stabilizing septin structure; regulated at post-translational level by cell cycle dependent phosphorylation; likely phosphorylated by Cdc28p and dephosphorylated by Cdc14p before cytokinesis; high-copy suppressor of synthetic lethality of sis2 sit4 double mutant; VHS2 has a paralog, MLF3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001397","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL135C"}


id: YIL136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OM45","product":"Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, extending into the intermembrane space; interacts with porin (Por1p) and with Om14p; imported via the presequence pathway involving the TOM and TIM23 complexes, then assembled in the outer membrane by Mim1p; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000001398","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL136W"}


id: YIL137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00181":null,"YIL137C":null},"has_protein_features":false,"name":"TMA108","ortholog_annotations":[{"gene_uniquename":"YIL137C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00181","reference_uniquename":"PMID:29761456"}],"product":"Ribosome-associated, nascent chain binding factor; binds N-terminal region of nascent peptides during translation; recognizes target proteins via its putative metallopeptidase peptide-binding pocket","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001399","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL137C"}


id: YIL138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04887":null,"YIL138C":null},"has_protein_features":false,"name":"TPM2","ortholog_annotations":[{"gene_uniquename":"YIL138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04887","reference_uniquename":"PMID:29761456"}],"product":"Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001400","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL138C"}


id: YIL139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00611":null,"YIL139C":null},"has_protein_features":false,"name":"REV7","ortholog_annotations":[{"gene_uniquename":"YIL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00611","reference_uniquename":"PMID:29761456"}],"product":"Accessory subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; may be involved in meiosis; forms a complex with Rev3p, Pol31p and Pol32p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001401","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL139C"}


id: YIL140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AXL2","product":"Integral plasma membrane protein; required for axial budding in haploid cells; localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate","secondary_identifier":"SGD:S000001402","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL140W"}


id: YIL141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001403","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL141W"}


id: YIL142C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF CCT2/YIL142W","secondary_identifier":"SGD:S000028796","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL142C-A"}


id: YIL142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01002":null,"YIL142W":null},"has_protein_features":false,"name":"CCT2","ortholog_annotations":[{"gene_uniquename":"YIL142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01002","reference_uniquename":"PMID:29761456"}],"product":"Subunit beta of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001404","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL142W"}


id: YIL143C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03206":null,"YIL143C":null},"has_protein_features":false,"name":"SSL2","ortholog_annotations":[{"gene_uniquename":"YIL143C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03206","reference_uniquename":"PMID:29761456"}],"product":"Component of RNA polymerase transcription factor TFIIH holoenzyme; acts as dsDNA-dependent translocase in context of TFIIH, unwinds DNA strands during initiation and promotes transcription start site (TSS) scanning; has DNA-dependent ATPase/helicase activity; interacts functionally with TFIIB, has roles in TSS selection and gene looping to juxtapose initiation and termination regions; involved in DNA repair; relocalizes to cytosol under hypoxia; homolog of human ERCC3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001405","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL143C"}


id: YIL144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04076":null,"YIL144W":null},"has_protein_features":false,"name":"NDC80","ortholog_annotations":[{"gene_uniquename":"YIL144W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04076","reference_uniquename":"PMID:29761456"}],"product":"Component of the kinetochore-associated Ndc80 complex; conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, and kinetochore assembly and clustering; evolutionarily conserved; complex members include Ndc80p, Nuf2p, Scp24p, and Spc25p; modified by sumoylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001406","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL144W"}


id: YIL145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03679":null,"YIL145C":null},"has_protein_features":false,"name":"PAN6","ortholog_annotations":[{"gene_uniquename":"YIL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03679","reference_uniquename":"PMID:29761456"}],"product":"Pantothenate synthase; also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001407","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL145C"}


id: YIL146C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATG32","product":"Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane; regulates mitophagy and ethanol production during alcoholic fermentation","secondary_identifier":"SGD:S000001408","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL146C"}


id: YIL147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00331":null,"SJAG_01587":null,"SJAG_02183":null,"YIL147C":null},"has_protein_features":false,"name":"SLN1","ortholog_annotations":[{"gene_uniquename":"YIL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00331","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01587","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02183","reference_uniquename":"PMID:29761456"}],"product":"Transmembrane histidine phosphotransfer kinase and osmosensor; regulates MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001409","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL147C"}


id: YIL148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01365":null,"SJAG_02891":null,"SJAG_03971":null,"YIL148W":null},"has_protein_features":false,"name":"RPL40A","ortholog_annotations":[{"gene_uniquename":"YIL148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01365","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02891","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03971","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001410","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL148W"}


id: YIL149C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03300":null,"SJAG_04645":null,"YIL149C":null},"has_protein_features":false,"name":"MLP2","ortholog_annotations":[{"gene_uniquename":"YIL149C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03300","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YIL149C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04645","reference_uniquename":"PMID:29761456"}],"product":"Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; MLP2 has a paralog, MLP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001411","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL149C"}


id: YIL150C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00399":null,"YIL150C":null},"has_protein_features":false,"name":"MCM10","ortholog_annotations":[{"gene_uniquename":"YIL150C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00399","reference_uniquename":"PMID:29761456"}],"product":"Essential chromatin-associated protein; involved in initiation of DNA replication; required for association of MCM2-7 complex with replication origins; required to stabilize catalytic subunit of DNA polymerase-alpha; coordinates function of replication fork helicase; self-associates through its N-terminal domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001412","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL150C"}


id: YIL151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ESL1","product":"hEST1A/B (SMG5/6)-like protein; contributes to environment-sensing adaptive gene expression responses; Esl1p and Esl2p contain a 14-3-3-like domain and a putative PilT N-terminus ribonuclease domain; ESL1 has a paralog, ESL2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001413","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL151C"}


id: YIL152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001414","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL152W"}


id: YIL153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01270":null,"YIL153W":null},"has_protein_features":false,"name":"RRD1","ortholog_annotations":[{"gene_uniquename":"YIL153W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01270","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001415","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL153W"}


id: YIL154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IMP21","product":"Transcriptional activator involved in maintenance of ion homeostasis; also involved in protection against DNA damage caused by bleomycin and other oxidants; contains a C-terminal leucine-rich repeat","secondary_identifier":"SGD:S000001416","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL154C"}


id: YIL155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GUT2","product":"Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner","secondary_identifier":"SGD:S000001417","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL155C"}


id: YIL156W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00742":null,"YIL156W":null},"has_protein_features":false,"name":"UBP7","ortholog_annotations":[{"gene_uniquename":"YIL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00742","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; involved in cell cycle progression through S phase; UBP7 has a paralog, UBP11, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001418","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL156W"}


id: YIL156W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF COA1/YIL157C","secondary_identifier":"SGD:S000028797","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL156W-A"}


id: YIL156W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05261":null,"YIL156W-B":null},"has_protein_features":false,"name":"MCO8","ortholog_annotations":[{"gene_uniquename":"YIL156W-B","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05261","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein of unknown function; originally identified based on homology to <i>Ashbya gossypii</i> and other related yeasts; SWAT-GFP and mCherry fusion proteins localize to the vacuole, while SWAT-GFP fusion also localizes to the endoplasmic reticulum","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028511","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL156W-B"}


id: YIL157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04603":null,"YIL157C":null},"has_protein_features":false,"name":"COA1","ortholog_annotations":[{"gene_uniquename":"YIL157C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04603","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein; required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001419","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL157C"}


id: YIL158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AIM20","product":"Protein of unknown function; overexpression causes cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress; AIM20 has a paralog, SKG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001420","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL158W"}


id: YIL159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00279":null,"SJAG_01943":null,"YIL159W":null},"has_protein_features":false,"name":"BNR1","ortholog_annotations":[{"gene_uniquename":"YIL159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00279","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YIL159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01943","reference_uniquename":"PMID:29761456"}],"product":"Formin; nucleates the formation of linear actin filaments; involved in processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables; activity is regulated by Hof1p and by the Bud14p-Kel1p-Kel2p complex; dephosphorylated and delocalized from the division site in a Glc7p/Ref2p-dependent manner; functionally redundant with BNI1","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL159W"}


id: YIL160C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"POT1","product":"3-ketoacyl-CoA thiolase with broad chain length specificity; cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids","secondary_identifier":"SGD:S000001422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL160C"}


id: YIL161W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene","secondary_identifier":"SGD:S000001423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL161W"}


id: YIL162W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04301":null,"YIL162W":null},"has_protein_features":false,"name":"SUC2","ortholog_annotations":[{"gene_uniquename":"YIL162W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04301","reference_uniquename":"PMID:29761456"}],"product":"Invertase; sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001424","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL162W"}


id: YIL163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data","secondary_identifier":"SGD:S000001425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL163C"}


id: YIL164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NIT1","product":"Nitrilase; member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene","secondary_identifier":"SGD:S000001426","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL164C"}


id: YIL165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene","secondary_identifier":"SGD:S000001427","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL165C"}


id: YIL166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SOA1","product":"Sulfonate and inorganic sulfur transporter; low affinity sulfate, high affinity sulfite, thiosulfite and major sulfonate transporter; functions as a an H+ symporter; similar to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; non-essential gene","secondary_identifier":"SGD:S000001428","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL166C"}


id: YIL167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SDL1","product":"Blocked reading frame otherwise encoding L-serine dehydratase","secondary_identifier":"SGD:S000001429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL167W"}


id: YIL169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CSS1","product":"Protein of unknown function, secreted when constitutively expressed; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cell periphery, SWAT-GFP fusion also localizes to the extracellular region, and mCherry fusion also localizes to the vacuole; S/T rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; non-essential gene","secondary_identifier":"SGD:S000001431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL169C"}


id: YIL171W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF IMA3/YIL172C","secondary_identifier":"SGD:S000028798","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL171W-A"}


id: YIL172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IMA3","product":"Alpha-glucosidase; weak, but broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima3p overexpression allows the ima1 null mutant to grow on isomaltose; lower activitiy and thermostability in vitro than Ima2p despite sequence difference of only 3 amino acids; cleaves alpha-1,3 linkage of nigerose and turanose, but not alpha-1,5 of leucrose; identical to IMA4","secondary_identifier":"SGD:S000001434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL172C"}


id: YIL173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01488":null,"YIL173W":null},"has_protein_features":false,"name":"VTH1","ortholog_annotations":[{"gene_uniquename":"YIL173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01488","reference_uniquename":"PMID:29761456"}],"product":"Putative membrane glycoprotein; has strong similarity to Vth2p and Pep1p/Vps10p; may be involved in vacuolar protein sorting","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL173W"}


id: YIL176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU14","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau1p","secondary_identifier":"SGD:S000001438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL176C"}


id: YIL177C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative Y' element ATP-dependent helicase","secondary_identifier":"SGD:S000001439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL177C"}


id: YIL177W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YIL177C","secondary_identifier":"SGD:S000028658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL177W-A"}


id: YIR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04601":null,"YIR001C":null},"has_protein_features":false,"name":"SGN1","ortholog_annotations":[{"gene_uniquename":"YIR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04601","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic RNA-binding protein; contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001440","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR001C"}


id: YIR002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02294":null,"SJAG_02690":null,"YIR002C":null},"has_protein_features":false,"name":"MPH1","ortholog_annotations":[{"gene_uniquename":"YIR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02294","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02690","reference_uniquename":"PMID:29761456"}],"product":"3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds flap DNA, stimulates activity of Rad27p and Dna2p; prevents crossovers between ectopic sequences by removing substrates for Mus81-Mms4 or Rad1-Rad10 cleavage; homolog of human FANCM Fanconi anemia protein that is involved in stabilizing and remodeling blocked replication forks; member of SF2 DExD/H superfamily of helicases; nonsense or missense mutations in FANCM can make people more likely to get cancer","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR002C"}


id: YIR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04172":null,"YIR003W":null},"has_protein_features":false,"name":"AIM21","ortholog_annotations":[{"gene_uniquename":"YIR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04172","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a complex that associates with actin filaments; forms a complex with Tda2p that inhibits barbed end F-actin assembly; elevates actin monomer pools to increase endocytotic efficiency and to regulate the distribution of actin between cables and patches; Aim21p/Tda2p forms a larger complex with actin capping proteins Cap1p and Cap2p; involved in mitochondrial migration along actin filaments; recruited to cortical actin patches by SH3 domain-containing proteins Bbc1p and Abp1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001442","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR003W"}


id: YIR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02034":null,"SJAG_02797":null,"YIR004W":null},"has_protein_features":false,"name":"DJP1","ortholog_annotations":[{"gene_uniquename":"YIR004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02797","reference_uniquename":"PMID:29761456"}],"product":"ER-associated chaperone involved in protein targeting; redirects mitochondrial membrane protein precursors to mitochondrial translocation system; required for peroxisomal protein import and involved in peroxisome assembly; facilitates import of Mim1p and Mim2p into the mitochondrial outer membrane; homologous to E. coli DnaJ","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001443","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR004W"}


id: YIR005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00313":null,"YIR005W":null},"has_protein_features":false,"name":"IST3","ortholog_annotations":[{"gene_uniquename":"YIR005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00313","reference_uniquename":"PMID:29761456"}],"product":"Component of the U2 snRNP; required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing; diploid mutants have a specific defect in MATa1 pre-mRNA splicing which leads to haploid gene expression in diploids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001444","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR005W"}


id: YIR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04886":null,"YIR006C":null},"has_protein_features":false,"name":"PAN1","ortholog_annotations":[{"gene_uniquename":"YIR006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04886","reference_uniquename":"PMID:29761456"}],"product":"Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p; associates with actin patches on cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates Arp2/3 complex in vitro; phosphorylation of Thr-1225 is regulated by MAPK Hog1p in response to osmotic stress; previously thought to be a subunit of poly(A) ribonuclease","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001445","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR006C"}


id: YIR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"EGH1","product":"Steryl-beta-glucosidase with broad specificity for aglycones; has a role in ergosteryl-beta-glucoside catabolism; required for normal vacuolar morphology; has similarity to the C. neoformans ergosteryl-beta-glucosidase EGCrP2; localizes to the cytosol","secondary_identifier":"SGD:S000001446","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR007W"}


id: YIR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04994":null,"YIR008C":null},"has_protein_features":false,"name":"PRI1","ortholog_annotations":[{"gene_uniquename":"YIR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04994","reference_uniquename":"PMID:29761456"}],"product":"Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001447","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR008C"}


id: YIR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03547":null,"YIR009W":null},"has_protein_features":false,"name":"MSL1","ortholog_annotations":[{"gene_uniquename":"YIR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03547","reference_uniquename":"PMID:29761456"}],"product":"U2B component of U2 snRNP; involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001448","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR009W"}


id: YIR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02346":null,"YIR010W":null},"has_protein_features":false,"name":"DSN1","ortholog_annotations":[{"gene_uniquename":"YIR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02346","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the outer kinetochore MIND complex; joins kinetochore subunits contacting DNA to those contacting microtubules; phosphorylation promotes interaction between outer and inner kinetochore proteins; kinetochore receptor for monopolin, via interaction with Csm1p; essential for both meiotic and mitotic chromosome segregation; MIND complex consists of Mtw1p, Nnf1p, Nsl1p and Dsn1p; phosphorylated by monopolin subunit, Hrr25p and Aurora kinase, Ipl1p; modified by sumoylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001449","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR010W"}


id: YIR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00054":null,"YIR011C":null},"has_protein_features":false,"name":"STS1","ortholog_annotations":[{"gene_uniquename":"YIR011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00054","reference_uniquename":"PMID:29761456"}],"product":"Protein required for localizing proteasomes to the nucleus; involved in cotranslational protein degradation; mediates interaction between nuclear import factor Srp1p and the proteasome; Sts1p and Srp1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation; involved in ubiquitin-mediated protein degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001450","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR011C"}


id: YIR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02436":null,"YIR012W":null},"has_protein_features":false,"name":"SQT1","ortholog_annotations":[{"gene_uniquename":"YIR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02436","reference_uniquename":"PMID:29761456"}],"product":"Specific assembly chaperone for ribosomal protein Rpl10p; co-translationally associates with nascent Rpl10p, preventing aggregation; involved in biogenesis of the ribosomal large subunit; contains multiple WD repeats; interacts genetically and physically with Qsr1p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001451","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR012W"}


id: YIR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GAT4","product":"Protein containing GATA family zinc finger motifs; involved in spore wall assembly; sequence similarity to GAT3, and the double mutant gat3 gat4 exhibits reduced dityrosine fluorescence relative to the single mutants","secondary_identifier":"SGD:S000001452","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR013C"}


id: YIR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"VLD1","product":"Component of Dsc E3 ligase complex in vacuolar membranes; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene","secondary_identifier":"SGD:S000001453","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR014W"}


id: YIR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00306":null,"YIR015W":null},"has_protein_features":false,"name":"RPR2","ortholog_annotations":[{"gene_uniquename":"YIR015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00306","reference_uniquename":"PMID:29761456"}],"product":"Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001454","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR015W"}


id: YIR016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR016W"}


id: YIR017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04749":null,"YIR017C":null},"has_protein_features":false,"name":"MET28","ortholog_annotations":[{"gene_uniquename":"YIR017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04749","reference_uniquename":"PMID:29761456"}],"product":"bZIP transcriptional activator in the Cbf1p-Met4p-Met28p complex; participates in the regulation of sulfur metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001456","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR017C"}


id: YIR017W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000028799","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR017W-A"}


id: YIR018C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028837","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR018C-A"}


id: YIR018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YAP5","product":"Basic leucine zipper (bZIP) iron-sensing transcription factor; senses high-iron conditions via two Fe/S clusters bound to its activator domain; involved in diauxic shift; YAP5 has a paralog, YAP7, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001457","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR018W"}


id: YIR019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FLO11","product":"GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal and invasive growth, flocculation, and biofilm formation; major determinant of colony morphology; QTL that controls chronological life span; carries intragenic tandem repeats that are expanded in different strains; required for formation of fibrous interconnections between cells; role in co-flocculation with other yeast species; cleaved and shed from cells, contributing to their surface properties","secondary_identifier":"SGD:S000001458","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR019C"}


id: YIR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data; SWAT-GFP fusion protein localizes to the endoplasmic reticulum","secondary_identifier":"SGD:S000001459","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR020C"}


id: YIR020C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF MRS1","secondary_identifier":"SGD:S000028800","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR020C-B"}


id: YIR020W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR020W-A"}


id: YIR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MRS1","product":"Splicing protein; required for splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA; MRS1 has a paralog, CCE1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001460","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR021W"}


id: YIR021W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028838","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR021W-A"}


id: YIR022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03261":null,"YIR022W":null},"has_protein_features":false,"name":"SEC11","ortholog_annotations":[{"gene_uniquename":"YIR022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03261","reference_uniquename":"PMID:29761456"}],"product":"18kDa catalytic subunit of the Signal Peptidase Complex (SPC); the Signal Peptidase Complex cleaves the signal sequence of proteins targeted to the endoplasmic reticulum; other members are Spc1p, Spc2p, Spc3p, and Sec11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001461","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR022W"}


id: YIR023C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF DAL81/YIR023W","secondary_identifier":"SGD:S000028801","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR023C-A"}


id: YIR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DAL81","product":"Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism","secondary_identifier":"SGD:S000001462","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR023W"}


id: YIR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"INA22","product":"F1F0 ATP synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex (Ina22p-Ina17p) involved in assembly of the F1F0 peripheral stalk; co-purifies with Aim43p, ATP synthase subunits, and cytochrome bc1 complex assembly factors; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect","secondary_identifier":"SGD:S000001463","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR024C"}


id: YIR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03037":null,"YIR025W":null},"has_protein_features":false,"name":"MND2","ortholog_annotations":[{"gene_uniquename":"YIR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03037","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001464","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR025W"}


id: YIR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01161":null,"YIR026C":null},"has_protein_features":false,"name":"YVH1","ortholog_annotations":[{"gene_uniquename":"YIR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01161","reference_uniquename":"PMID:29761456"}],"product":"Dual specificity protein phosphatase; regulates growth, sporulation, and glycogen accumulation in a cAMP-dependent protein kinase cascade dependent manner; mutants are defective in 60S ribosome assembly; positively regulates pre-autophagosomal structure (PAS) formation upon nitrogen starvation or rapamycin treatment","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001465","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR026C"}


id: YIR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DAL1","product":"Allantoinase; converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression","secondary_identifier":"SGD:S000001466","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR027C"}


id: YIR028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02147":null,"SJAG_04714":null,"YIR028W":null},"has_protein_features":false,"name":"DAL4","ortholog_annotations":[{"gene_uniquename":"YIR028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02147","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YIR028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04714","reference_uniquename":"PMID:29761456"}],"product":"Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001467","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR028W"}


id: YIR029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00035":null,"YIR029W":null},"has_protein_features":false,"name":"DAL2","ortholog_annotations":[{"gene_uniquename":"YIR029W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00035","reference_uniquename":"PMID:29761456"}],"product":"Allantoicase; converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001468","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR029W"}


id: YIR030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00036":null,"SJAG_04298":null,"YIR030C":null},"has_protein_features":false,"name":"DCG1","ortholog_annotations":[{"gene_uniquename":"YIR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00036","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04298","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001469","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR030C"}


id: YIR030W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF DAL7/YIR031C","secondary_identifier":"SGD:S000028802","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR030W-A"}


id: YIR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DAL7","product":"Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation","secondary_identifier":"SGD:S000001470","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR031C"}


id: YIR032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05287":null,"YIR032C":null},"has_protein_features":false,"name":"DAL3","ortholog_annotations":[{"gene_uniquename":"YIR032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05287","reference_uniquename":"PMID:29761456"}],"product":"Ureidoglycolate lyase; converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression is sensitive to nitrogen catabolite repression; this enzyme is sometimes referred to 'ureidoglycolate hydrolase' but should not be confused with the Arabidopsis thaliana ureidoglycolate hydrolase enzyme which converts ureidoglycolate to glyoxylate, ammonia and carbon dioxide","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001471","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR032C"}


id: YIR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02196":null,"YIR033W":null},"has_protein_features":false,"name":"MGA2","ortholog_annotations":[{"gene_uniquename":"YIR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02196","reference_uniquename":"PMID:29761456"}],"product":"ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; MGA2 has a paralog, SPT23, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR033W"}


id: YIR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02388":null,"YIR034C":null},"has_protein_features":false,"name":"LYS1","ortholog_annotations":[{"gene_uniquename":"YIR034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02388","reference_uniquename":"PMID:29761456"}],"product":"Saccharopine dehydrogenase (NAD+, L-lysine-forming); catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001473","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR034C"}


id: YIR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03098":null,"YIR035C":null},"has_protein_features":false,"name":"NRE1","ortholog_annotations":[{"gene_uniquename":"YIR035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03098","reference_uniquename":"PMID:29761456"}],"product":"Putative cytoplasmic short-chain dehydrogenase/reductase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001474","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR035C"}


id: YIR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03098":null,"YIR036C":null},"has_protein_features":false,"name":"IRC24","ortholog_annotations":[{"gene_uniquename":"YIR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03098","reference_uniquename":"PMID:29761456"}],"product":"Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001475","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR036C"}


id: YIR036W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF IRC24/YIR036C","secondary_identifier":"SGD:S000028803","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR036W-A"}


id: YIR037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01216":null,"YIR037W":null},"has_protein_features":false,"name":"HYR1","ortholog_annotations":[{"gene_uniquename":"YIR037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01216","reference_uniquename":"PMID:29761456"}],"product":"Glutathione peroxidase; functions as hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce redox signal to Yap1p transcription factor; glutathione peroxidase activity is neuroprotective in models of Huntington's disease; HYR1 has a paralog, GPX1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001476","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR037W"}


id: YIR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05181":null,"YIR038C":null},"has_protein_features":false,"name":"GTT1","ortholog_annotations":[{"gene_uniquename":"YIR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05181","reference_uniquename":"PMID:29761456"}],"product":"ER associated glutathione S-transferase; capable of homodimerization; glutathione transferase for Yvc1p vacuolar cation channel; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001477","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR038C"}


id: YIR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00109":null,"SJAG_00254":null,"SJAG_00784":null,"SJAG_02260":null,"YIR039C":null},"has_protein_features":false,"name":"YPS6","ortholog_annotations":[{"gene_uniquename":"YIR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00109","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00254","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00784","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02260","reference_uniquename":"PMID:29761456"}],"product":"Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001478","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR039C"}


id: YIR040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001479","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR040C"}


id: YIR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU15","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole","secondary_identifier":"SGD:S000001480","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR041W"}


id: YIR042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YIR042C is a non-essential gene","secondary_identifier":"SGD:S000001481","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR042C"}


