# genes

id: YOL018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04978":null,"YOL018C":null},"has_protein_features":false,"name":"TLG2","ortholog_annotations":[{"gene_uniquename":"YOL018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04978","reference_uniquename":"PMID:29761456"}],"product":"Syntaxin-like t-SNARE; forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; required along with VPS45 for an early step of the constitutive CVT pathway; interactions with Vps45 prevents Tlg2p degradation, and facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL018C"}


id: YOL019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01189":null,"SJAG_04058":null,"YOL019W":null},"has_protein_features":false,"name":"TOS7","ortholog_annotations":[{"gene_uniquename":"YOL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01189","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04058","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in secretion and cell wall organization; localizes to plasma membrane microdomains called MCCs (membrane compartment occupied by Can1); GFP-fusion protein localizes to the cell periphery and vacuole; Sur7/PalI family transmembrane domain (TMD) containing protein; TOS7 has a paralog, DCV1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL019W"}


id: YOL019W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028707","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL019W-A"}


id: YOL020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YOL020W":null},"has_protein_features":false,"name":"TAT2","ortholog_annotations":[{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"High affinity tryptophan and tyrosine permease; overexpression confers FK506 and FTY720 resistance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL020W"}


id: YOL021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04006":null,"YOL021C":null},"has_protein_features":false,"name":"DIS3","ortholog_annotations":[{"gene_uniquename":"YOL021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04006","reference_uniquename":"PMID:29761456"}],"product":"Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; similar to E. coli RNase R and to human DIS3, which partially complements dis3-81 heat sensitivity; mutations in Dis3p analogous to human mutations implicated in multiple myeloma impair exosome function; protein abundance increases under to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL021C"}


id: YOL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02911":null,"SJAG_03857":null,"YOL022C":null},"has_protein_features":false,"name":"TSR4","ortholog_annotations":[{"gene_uniquename":"YOL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02911","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03857","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic assembly chaperone for ribosomal protein Rps2p; co-translationally associates with the N-terminal extension of Rps2p to facilitate expression, solubility and ribosome assembly; released prior to the nuclear import of Rps2p; required for correct processing of 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in the S288C background but not in CEN.PK2; homologous to human PDCD2L and PDCD2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL022C"}


id: YOL023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02856":null,"YOL023W":null},"has_protein_features":false,"name":"IFM1","ortholog_annotations":[{"gene_uniquename":"YOL023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02856","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial translation initiation factor 2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005383","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL023W"}


id: YOL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL024W"}


id: YOL025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LAG2","product":"Protein that negatively regulates the SCF E3-ubiquitin ligase; regulates by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1","secondary_identifier":"SGD:S000005385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL025W"}


id: YOL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00569":null,"YOL026C":null},"has_protein_features":false,"name":"MIM1","ortholog_annotations":[{"gene_uniquename":"YOL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00569","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; forms a complex with Mim2p in the outer membrane that functions as cation-selective channel for translocation of positively charged precursor segments; also has a role in assembly of Tom20p into the TOM complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL026C"}


id: YOL027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01806":null,"YOL027C":null},"has_protein_features":false,"name":"MDM38","ortholog_annotations":[{"gene_uniquename":"YOL027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01806","reference_uniquename":"PMID:29761456"}],"product":"Membrane-associated mitochondrial ribosome receptor; forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; ribosome-associated protein involved in the insertion of newly synthesized proteins into the mitochondrial inner membrane; role in protein export and K+/H+ exchange; localizes to the inner mitochondrial membrane; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL027C"}


id: YOL028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YAP7","product":"Transcriptional repressor of nitric oxide oxidase; basic leucine zipper (bZIP) transcription factor; neighboring gene, YOL029C, created by frame-shift at position 708, corresponds to C-terminal part of YAP7 orthologs in other species; YAP7 has a paralog, YAP5, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL028C"}


id: YOL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; separated from neighboring gene, YAP7, by frame shift and corresponds to C-terminal part of YAP7 orthologs in other species; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens","secondary_identifier":"SGD:S000005389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL029C"}


id: YOL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00218":null,"SJAG_04483":null,"YOL030W":null},"has_protein_features":false,"name":"GAS5","ortholog_annotations":[{"gene_uniquename":"YOL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00218","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04483","reference_uniquename":"PMID:29761456"}],"product":"1,3-beta-glucanosyltransferase; has similarity to Gas1p; localizes to the cell wall","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL030W"}


id: YOL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SIL1","product":"Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; required for protein translocation into the endoplasmic reticulum (ER); homolog of Yarrowia lipolytica SLS1; GrpE-like protein","secondary_identifier":"SGD:S000005391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL031C"}


id: YOL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00586":null,"YOL032W":null},"has_protein_features":false,"name":"OPI10","ortholog_annotations":[{"gene_uniquename":"YOL032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00586","reference_uniquename":"PMID:29761456"}],"product":"Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL032W"}


id: YOL033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03071":null,"YOL033W":null},"has_protein_features":false,"name":"MSE1","ortholog_annotations":[{"gene_uniquename":"YOL033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03071","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial glutamyl-tRNA synthetase; predicted to be palmitoylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL033W"}


id: YOL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03436":null,"YOL034W":null},"has_protein_features":false,"name":"SMC5","ortholog_annotations":[{"gene_uniquename":"YOL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03436","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; supports nucleolar function; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005394","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL034W"}


id: YOL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005395","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL035C"}


id: YOL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005396","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL036W"}


id: YOL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W","secondary_identifier":"SGD:S000005397","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL037C"}


id: YOL038C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by SAGE analysis","secondary_identifier":"SGD:S000028812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL038C-A"}


id: YOL038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04306":null,"YOL038W":null},"has_protein_features":false,"name":"PRE6","ortholog_annotations":[{"gene_uniquename":"YOL038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04306","reference_uniquename":"PMID:29761456"}],"product":"Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005398","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL038W"}


id: YOL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01128":null,"SJAG_02871":null,"YOL039W":null},"has_protein_features":false,"name":"RPP2A","ortholog_annotations":[{"gene_uniquename":"YOL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01128","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02871","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein P2 alpha; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005399","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL039W"}


id: YOL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02870":null,"SJAG_04256":null,"YOL040C":null},"has_protein_features":false,"name":"RPS15","ortholog_annotations":[{"gene_uniquename":"YOL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02870","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04256","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005400","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL040C"}


id: YOL041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05190":null,"YOL041C":null},"has_protein_features":false,"name":"NOP12","ortholog_annotations":[{"gene_uniquename":"YOL041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05190","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein involved in pre-25S rRNA processing; also involved in biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005401","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL041C"}


id: YOL042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NGL1","product":"Putative endonuclease; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000005402","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL042W"}


id: YOL043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03724":null,"YOL043C":null},"has_protein_features":false,"name":"NTG2","ortholog_annotations":[{"gene_uniquename":"YOL043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03724","reference_uniquename":"PMID:29761456"}],"product":"DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005403","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL043C"}


id: YOL044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEX15","product":"Tail-anchored type II integral peroxisomal membrane protein; required for peroxisome biogenesis; cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol; overexpression results in impaired peroxisome assembly","secondary_identifier":"SGD:S000005404","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL044W"}


id: YOL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01376":null,"YOL045W":null},"has_protein_features":false,"name":"PSK2","ortholog_annotations":[{"gene_uniquename":"YOL045W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01376","reference_uniquename":"PMID:29761456"}],"product":"PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005405","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL045W"}


id: YOL046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene PSK2/YOL045W","secondary_identifier":"SGD:S000005406","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL046C"}


id: YOL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LDS2","product":"Protein Involved in spore wall assembly; localizes to lipid droplets found on or outside of the prospore membrane; shares similarity with Lds1p and Rrt8p, and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern","secondary_identifier":"SGD:S000005407","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL047C"}


id: YOL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RRT8","product":"Protein involved in spore wall assembly; shares similarity with Lds1p and Lds2p and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000005408","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL048C"}


id: YOL049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01351":null,"YOL049W":null},"has_protein_features":false,"name":"GSH2","ortholog_annotations":[{"gene_uniquename":"YOL049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01351","reference_uniquename":"PMID:29761456"}],"product":"Glutathione synthetase; catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005409","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL049W"}


id: YOL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)","secondary_identifier":"SGD:S000005410","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL050C"}


id: YOL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03981":null,"YOL051W":null},"has_protein_features":false,"name":"GAL11","ortholog_annotations":[{"gene_uniquename":"YOL051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03981","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005411","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL051W"}


id: YOL052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03632":null,"YOL052C":null},"has_protein_features":false,"name":"SPE2","ortholog_annotations":[{"gene_uniquename":"YOL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03632","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine decarboxylase; required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005412","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL052C"}


id: YOL052C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DDR2","product":"Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005413","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL052C-A"}


id: YOL053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AIM39","product":"Protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss","secondary_identifier":"SGD:S000005414","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL053W"}


id: YOL054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01854":null,"SJAG_03615":null,"YOL054W":null},"has_protein_features":false,"name":"PSH1","ortholog_annotations":[{"gene_uniquename":"YOL054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01854","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03615","reference_uniquename":"PMID:29761456"}],"product":"E3 ubiquitin ligase targeting centromere-binding protein Cse4p; mediates polyubiquitination and degradation of histone H3 variant Cse4p; ubiquitination of Cse4p may be antagonized by Scm3p; interacts with the FACT complex preventing mislocalization of Cse4p to euchromatin independent of Slx5p; formyl-methionine/N-recognin component of N-end rule pathway mediating destruction of formylated cytosolic proteins elevated in response to starvation or stationary phase entry","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005415","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL054W"}


id: YOL055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02420":null,"SJAG_02421":null,"SJAG_04282":null,"YOL055C":null},"has_protein_features":false,"name":"THI20","ortholog_annotations":[{"gene_uniquename":"YOL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02420","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02421","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04282","reference_uniquename":"PMID:29761456"}],"product":"Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005416","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL055C"}


id: YOL056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02009":null,"YOL056W":null},"has_protein_features":false,"name":"GPM3","ortholog_annotations":[{"gene_uniquename":"YOL056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02009","reference_uniquename":"PMID:29761456"}],"product":"Nonfunctional homolog of Gpm1p phosphoglycerate mutase; if functional, would convert 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; GPM3 has a paralog, GPM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005417","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL056W"}


id: YOL057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers","secondary_identifier":"SGD:S000005418","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL057W"}


id: YOL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04577":null,"YOL058W":null},"has_protein_features":false,"name":"ARG1","ortholog_annotations":[{"gene_uniquename":"YOL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04577","reference_uniquename":"PMID:29761456"}],"product":"Arginosuccinate synthetase; catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005419","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL058W"}


id: YOL059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00409":null,"YOL059W":null},"has_protein_features":false,"name":"GPD2","ortholog_annotations":[{"gene_uniquename":"YOL059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00409","reference_uniquename":"PMID:29761456"}],"product":"NAD-dependent glycerol 3-phosphate dehydrogenase; expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1; GPD2 has a paralog, GPD1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005420","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL059W"}


id: YOL060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04111":null,"YOL060C":null},"has_protein_features":false,"name":"MAM3","ortholog_annotations":[{"gene_uniquename":"YOL060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04111","reference_uniquename":"PMID:29761456"}],"product":"Protein required for normal mitochondrial morphology; has similarity to hemolysins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL060C"}


id: YOL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04882":null,"YOL061W":null},"has_protein_features":false,"name":"PRS5","ortholog_annotations":[{"gene_uniquename":"YOL061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04882","reference_uniquename":"PMID:29761456"}],"product":"5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL061W"}


id: YOL062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00800":null,"YOL062C":null},"has_protein_features":false,"name":"APM4","ortholog_annotations":[{"gene_uniquename":"YOL062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00800","reference_uniquename":"PMID:29761456"}],"product":"Cargo-binding mu subunit of AP-2; AP-2 is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required for AP-2 function and localization, and binds cell wall stress receptor Mid2p; AP-2 is required for cell polarity responses to pheromone, nutritional status and cell wall damage in S. cerevisiae, and for hyphal growth in C. albicans; AP-2 complex is conserved in mammals","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL062C"}


id: YOL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03507":null,"YOL063C":null},"has_protein_features":false,"name":"CRT10","ortholog_annotations":[{"gene_uniquename":"YOL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03507","reference_uniquename":"PMID:29761456"}],"product":"Protein required for the degradation of mutant 25S rRNAs; functions in Mms1 pathway of nonfunctional 25S rRNA decay; expression induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005424","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL063C"}


id: YOL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01702":null,"YOL064C":null},"has_protein_features":false,"name":"MET22","ortholog_annotations":[{"gene_uniquename":"YOL064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01702","reference_uniquename":"PMID:29761456"}],"product":"Bisphosphate-3'-nucleotidase; involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway; human homolog BPNT1 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL064C"}


id: YOL065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"INP54","product":"Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; role in secretion; localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins","secondary_identifier":"SGD:S000005426","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL065C"}


id: YOL066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01054":null,"YOL066C":null},"has_protein_features":false,"name":"RIB2","ortholog_annotations":[{"gene_uniquename":"YOL066C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01054","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional DRAP deaminase tRNA:pseudouridine synthase; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs; RIB2 has a paralog, PUS9, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005427","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL066C"}


id: YOL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RTG1","product":"Transcription factor (bHLH) involved in interorganelle communication; contributes to communication between mitochondria, peroxisomes, and nucleus; target of Hog1p; activated in stochastic pulses of nuclear localization","secondary_identifier":"SGD:S000005428","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL067C"}


id: YOL068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04186":null,"YOL068C":null},"has_protein_features":false,"name":"HST1","ortholog_annotations":[{"gene_uniquename":"YOL068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04186","reference_uniquename":"PMID:29761456"}],"product":"NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and meiotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL068C"}


id: YOL069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00794":null,"YOL069W":null},"has_protein_features":false,"name":"NUF2","ortholog_annotations":[{"gene_uniquename":"YOL069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00794","reference_uniquename":"PMID:29761456"}],"product":"Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005430","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL069W"}


id: YOL070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NBA1","product":"Protein involved in axial bud site selection; prevents repolarization of cells at previous division sites; recruited by Aim44p and Nap1p to the cell cortex and to cytokinesis remnants (bud scars) where it prevents Rsr1p-mediated activation of Cdc24p, the Cdc42p GEF; localizes to the cytoplasm, and the cell division site prior to being stably recruited to cytokinesis remnants; establishes the transient localization of Rga1p, a Cdc42p GAP, at bud scars along with Nis1p; potential Cdc28p substrate","secondary_identifier":"SGD:S000005431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL070C"}


id: YOL071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01895":null,"YOL071W":null},"has_protein_features":false,"name":"SDH5","ortholog_annotations":[{"gene_uniquename":"YOL071W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01895","reference_uniquename":"PMID:29761456"}],"product":"Protein required for flavinylation of Sdh1p; binds to Sdh1p and promotes FAD cofactor attachment, which is necessary for succinate dehydrogenase (SDH) complex assembly and activity; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005432","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL071W"}


id: YOL072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00298":null,"YOL072W":null},"has_protein_features":false,"name":"THP1","ortholog_annotations":[{"gene_uniquename":"YOL072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00298","reference_uniquename":"PMID:29761456"}],"product":"Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005433","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL072W"}


id: YOL073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03302":null,"YOL073C":null},"has_protein_features":false,"name":"DSC2","ortholog_annotations":[{"gene_uniquename":"YOL073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03302","reference_uniquename":"PMID:29761456"}],"product":"Multi-transmembrane subunit of the DSC ubiquitin ligase complex; similar in sequence to rhomboid pseudoproteases Der1p and UBAC2 that function in ERAD; ortholog of fission yeast dsc2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL073C"}


id: YOL075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative ABC transporter","secondary_identifier":"SGD:S000005435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL075C"}


id: YOL076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03045":null,"YOL076W":null},"has_protein_features":false,"name":"MDM20","ortholog_annotations":[{"gene_uniquename":"YOL076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03045","reference_uniquename":"PMID:29761456"}],"product":"Non-catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005436","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL076W"}


id: YOL077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02508":null,"YOL077C":null},"has_protein_features":false,"name":"BRX1","ortholog_annotations":[{"gene_uniquename":"YOL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02508","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005437","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL077C"}


id: YOL077W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_07003":null,"YOL077W-A":null},"has_protein_features":false,"name":"ATP19","ortholog_annotations":[{"gene_uniquename":"YOL077W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07003","reference_uniquename":"PMID:29761456"}],"product":"Subunit k of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007339","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL077W-A"}


id: YOL078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00117":null,"YOL078W":null},"has_protein_features":false,"name":"AVO1","ortholog_annotations":[{"gene_uniquename":"YOL078W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00117","reference_uniquename":"PMID:29761456"}],"product":"Component of the membrane-bound TORC2 complex; binds to phosphoinositide-(4,5)-bisphosphate through the C-terminal PH domain, anchoring TORC2 to the plasma membrane; binds directly to Tor2p substrate and downstream TORC2 effector Ypk2p, through the conserved central CRIM domain; may function along with Tsc11p as a scaffold for integrity of the TORC2 complex; role in regulating actin organization and growth control; orthologous to human MAPKAP1/SIN1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL078W"}


id: YOL079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL079W"}


id: YOL080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00841":null,"YOL080C":null},"has_protein_features":false,"name":"REX4","ortholog_annotations":[{"gene_uniquename":"YOL080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00841","reference_uniquename":"PMID:29761456"}],"product":"Putative RNA exonuclease; possibly involved in pre-rRNA processing and ribosome assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005440","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL080C"}


id: YOL081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IRA2","product":"GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; IRA2 has a paralog, IRA1, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis","secondary_identifier":"SGD:S000005441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL081W"}


id: YOL082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03976":null,"YOL082W":null},"has_protein_features":false,"name":"ATG19","ortholog_annotations":[{"gene_uniquename":"YOL082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03976","reference_uniquename":"PMID:29761456"}],"product":"Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles; interaction with Atg19p during the Cvt pathway requires phosphorylation by Hrr25p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005442","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL082W"}


id: YOL083C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028853","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL083C-A"}


id: YOL083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATG34","product":"Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog","secondary_identifier":"SGD:S000005443","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL083W"}


id: YOL084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PHM7","product":"Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000005444","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL084W"}


id: YOL085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YOL085C is not an essential gene; partially overlaps dubious ORF YOL085W-A","secondary_identifier":"SGD:S000005445","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL085C"}


id: YOL085W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C","secondary_identifier":"SGD:S000028708","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL085W-A"}


id: YOL086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01414":null,"SJAG_03370":null,"YOL086C":null},"has_protein_features":false,"name":"ADH1","ortholog_annotations":[{"gene_uniquename":"YOL086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01414","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03370","reference_uniquename":"PMID:29761456"}],"product":"Alcohol dehydrogenase; fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway; ADH1 has a paralog, ADH5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005446","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL086C"}


id: YOL086W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00935":null,"YOL086W-A":null},"has_protein_features":false,"name":"MHF1","ortholog_annotations":[{"gene_uniquename":"YOL086W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00935","reference_uniquename":"PMID:29761456"}],"product":"Component of the heterotetrameric MHF histone-fold complex; in humans the MHF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL086W-A"}


id: YOL087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00805":null,"YOL087C":null},"has_protein_features":false,"name":"DUF1","ortholog_annotations":[{"gene_uniquename":"YOL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00805","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005447","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL087C"}


id: YOL088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03414":null,"YOL088C":null},"has_protein_features":false,"name":"MPD2","ortholog_annotations":[{"gene_uniquename":"YOL088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03414","reference_uniquename":"PMID:29761456"}],"product":"Member of the protein disulfide isomerase (PDI) family; exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005448","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL088C"}


id: YOL089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HAL9","product":"Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005449","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL089C"}


id: YOL090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02226":null,"YOL090W":null},"has_protein_features":false,"name":"MSH2","ortholog_annotations":[{"gene_uniquename":"YOL090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02226","reference_uniquename":"PMID:29761456"}],"product":"Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP; required for silencing at the silent mating-type loci and telomeres","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005450","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL090W"}


id: YOL091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPO21","product":"Component of the meiotic outer plaque of the spindle pole body; involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation; SPO21 has a paralog, YSW1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005451","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL091W"}


id: YOL092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00051":null,"SJAG_04787":null,"YOL092W":null},"has_protein_features":false,"name":"YPQ1","ortholog_annotations":[{"gene_uniquename":"YOL092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00051","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04787","reference_uniquename":"PMID:29761456"}],"product":"Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; YPQ1 has a paralog, RTC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005452","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL092W"}


id: YOL093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04993":null,"YOL093W":null},"has_protein_features":false,"name":"TRM10","ortholog_annotations":[{"gene_uniquename":"YOL093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04993","reference_uniquename":"PMID:29761456"}],"product":"tRNA methyltransferase; methylates the N-1 position of guanine at position 9 in tRNAs; protein abundance increases in response to DNA replication stress; member of the SPOUT (SpoU-TrmD) methyltransferase family; human ortholog TRMT10A plays a role in the pathogenesis of microcephaly and early onset diabetes; an 18-mer originates from the TRM10 locus; genetic analysis shows the 18-mer is the translation regulator","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005453","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL093W"}


id: YOL094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00729":null,"YOL094C":null},"has_protein_features":false,"name":"RFC4","ortholog_annotations":[{"gene_uniquename":"YOL094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00729","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005454","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL094C"}


id: YOL095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HMI1","product":"Mitochondrial inner membrane localized ATP-dependent DNA helicase; required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD","secondary_identifier":"SGD:S000005455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL095C"}


id: YOL096C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01911":null,"SJAG_04642":null,"YOL096C":null},"has_protein_features":false,"name":"COQ3","ortholog_annotations":[{"gene_uniquename":"YOL096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01911","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04642","reference_uniquename":"PMID:29761456"}],"product":"O-methyltransferase; catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005456","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL096C"}


id: YOL097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01522":null,"YOL097C":null},"has_protein_features":false,"name":"WRS1","ortholog_annotations":[{"gene_uniquename":"YOL097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01522","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic tryptophanyl-tRNA synthetase; aminoacylates tryptophanyl-tRNA; human homolog WARS can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005457","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL097C"}


id: YOL097W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028854","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL097W-A"}


id: YOL098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03393":null,"YOL098C":null},"has_protein_features":false,"name":"SDD3","ortholog_annotations":[{"gene_uniquename":"YOL098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03393","reference_uniquename":"PMID:29761456"}],"product":"Putative metalloprotease; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005458","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL098C"}


id: YOL099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes","secondary_identifier":"SGD:S000005459","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL099C"}


id: YOL100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02468":null,"SJAG_05290":null,"YOL100W":null},"has_protein_features":false,"name":"PKH2","ortholog_annotations":[{"gene_uniquename":"YOL100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02468","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05290","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; contains a PH-like domain; redundant with Pkh1p; PKH2 has a paralog, PKH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005460","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL100W"}


id: YOL101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IZH4","product":"Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress; IZH4 has a paralog, IZH1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005461","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL101C"}


id: YOL102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03913":null,"YOL102C":null},"has_protein_features":false,"name":"TPT1","ortholog_annotations":[{"gene_uniquename":"YOL102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03913","reference_uniquename":"PMID:29761456"}],"product":"tRNA 2'-phosphotransferase that catalyzes final step in tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005462","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL102C"}


id: YOL103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03595":null,"SJAG_04506":null,"YOL103W":null},"has_protein_features":false,"name":"ITR2","ortholog_annotations":[{"gene_uniquename":"YOL103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03595","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04506","reference_uniquename":"PMID:29761456"}],"product":"Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog, ITR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005463","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL103W"}


id: YOL104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NDJ1","product":"Protein that regulates meiotic SPB cohesion and telomere clustering; localizes to both spindle pole bodies (SPBs) and telomeres; required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement","secondary_identifier":"SGD:S000005464","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL104C"}


id: YOL105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02258":null,"YOL105C":null},"has_protein_features":false,"name":"WSC3","ortholog_annotations":[{"gene_uniquename":"YOL105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02258","reference_uniquename":"PMID:29761456"}],"product":"Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity; involved in response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis; WSC3 has a paralog, WSC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005465","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL105C"}


id: YOL106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005466","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL106W"}


id: YOL107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01927":null,"YOL107W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOL107W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01927","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005467","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL107W"}


id: YOL108C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"INO4","product":"Transcription factor involved in phospholipid synthesis; required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain","secondary_identifier":"SGD:S000005468","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL108C"}


id: YOL109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ZEO1","product":"Peripheral membrane protein of the plasma membrane; interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria","secondary_identifier":"SGD:S000005469","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL109W"}


id: YOL110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01349":null,"YOL110W":null},"has_protein_features":false,"name":"SHR5","ortholog_annotations":[{"gene_uniquename":"YOL110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01349","reference_uniquename":"PMID:29761456"}],"product":"Palmitoyltransferase subunit; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization; Palmitoyltransferase is composed of Shr5p and Erf2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005470","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL110W"}


id: YOL111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MDY2","product":"Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes","secondary_identifier":"SGD:S000005471","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL111C"}


id: YOL112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01048":null,"YOL112W":null},"has_protein_features":false,"name":"MSB4","ortholog_annotations":[{"gene_uniquename":"YOL112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01048","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein of the Ras superfamily; acts primarily on Sec4p, localizes to the bud site and bud tip; msb3 msb4 double mutation causes defects in secretion and actin organization; similar to the TBC-domain Tre2 oncogene; MSB4 has a paralog, MSB3, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL112W"}


id: YOL113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02878":null,"YOL113W":null},"has_protein_features":false,"name":"SKM1","ortholog_annotations":[{"gene_uniquename":"YOL113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02878","reference_uniquename":"PMID:29761456"}],"product":"Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005473","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL113W"}


id: YOL114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05221":null,"YOL114C":null},"has_protein_features":false,"name":"PTH4","ortholog_annotations":[{"gene_uniquename":"YOL114C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05221","reference_uniquename":"PMID:29761456"}],"product":"Protein similar to the human peptidyl-tRNA hydrolase gene ICT1; associates with mitochondrial large subunit; may function in translation termination; YOL114C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005474","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL114C"}


id: YOL115W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01176":null,"YOL115W":null},"has_protein_features":false,"name":"PAP2","ortholog_annotations":[{"gene_uniquename":"YOL115W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01176","reference_uniquename":"PMID:29761456"}],"product":"Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of TRAMP; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; required for mRNA surveillance and maintenance of genome integrity, serving as a link between RNA and DNA metabolism; overlapping but non-redundant functions with Trf5p; relocalizes to cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005475","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL115W"}


id: YOL116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MSN1","product":"Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000005476","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL116W"}


id: YOL117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RRI2","product":"Subunit of the COP9 signalosome (CSN) complex; this complex cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response","secondary_identifier":"SGD:S000005477","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL117W"}


id: YOL118C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000005478","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL118C"}


id: YOL119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MCH4","product":"Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport","secondary_identifier":"SGD:S000005479","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL119C"}


id: YOL120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02597":null,"SJAG_03335":null,"YOL120C":null},"has_protein_features":false,"name":"RPL18A","ortholog_annotations":[{"gene_uniquename":"YOL120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02597","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03335","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005480","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL120C"}


id: YOL121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01296":null,"SJAG_02335":null,"YOL121C":null},"has_protein_features":false,"name":"RPS19A","ortholog_annotations":[{"gene_uniquename":"YOL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02335","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005481","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL121C"}


id: YOL122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01007":null,"YOL122C":null},"has_protein_features":false,"name":"SMF1","ortholog_annotations":[{"gene_uniquename":"YOL122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01007","reference_uniquename":"PMID:29761456"}],"product":"Divalent metal ion transporter; broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005482","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL122C"}


id: YOL123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03853":null,"YOL123W":null},"has_protein_features":false,"name":"HRP1","ortholog_annotations":[{"gene_uniquename":"YOL123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03853","reference_uniquename":"PMID:29761456"}],"product":"Subunit of cleavage factor I; cleavage factor I is a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences; required for genome stability; plays a role in copper homeostasis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005483","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL123W"}


id: YOL124C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04181":null,"YOL124C":null},"has_protein_features":false,"name":"TRM11","ortholog_annotations":[{"gene_uniquename":"YOL124C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04181","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of adoMet-dependent tRNA methyltransferase complex; required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain; another complex member is Trm112p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005484","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL124C"}


id: YOL125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01375":null,"YOL125W":null},"has_protein_features":false,"name":"TRM13","ortholog_annotations":[{"gene_uniquename":"YOL125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01375","reference_uniquename":"PMID:29761456"}],"product":"2'-O-methyltransferase; responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005485","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL125W"}


id: YOL126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MDH2","product":"Cytoplasmic malate dehydrogenase; one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1; mutation in human homolog MDH2 causes early-onset severe encephalopathy","secondary_identifier":"SGD:S000005486","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL126C"}


id: YOL127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02840":null,"SJAG_04304":null,"YOL127W":null},"has_protein_features":false,"name":"RPL25","ortholog_annotations":[{"gene_uniquename":"YOL127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02840","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04304","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005487","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL127W"}


id: YOL128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YGK3","product":"Protein kinase related to mammalian GSK-3 glycogen synthase kinases; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation; YGK3 has a paralog, MCK1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005488","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL128C"}


id: YOL129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03511":null,"YOL129W":null},"has_protein_features":false,"name":"VPS68","ortholog_annotations":[{"gene_uniquename":"YOL129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03511","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane protein of unknown function; involved in vacuolar protein sorting; also detected in the mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005489","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL129W"}


id: YOL130W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03516":null,"YOL130W":null},"has_protein_features":false,"name":"ALR1","ortholog_annotations":[{"gene_uniquename":"YOL130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03516","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane Mg(2+) transporter; expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; magnesium transport defect of the null mutant is functionally complemented by either of the human genes MAGT1 and TUSC3 that are not orthologous to ALR1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005490","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL130W"}


id: YOL131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; YOL131W has a paralog, STB1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005491","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL131W"}


id: YOL132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01835":null,"YOL132W":null},"has_protein_features":false,"name":"GAS4","ortholog_annotations":[{"gene_uniquename":"YOL132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01835","reference_uniquename":"PMID:26896847"}],"product":"1,3-beta-glucanosyltransferase; involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000005492","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL132W"}


id: YOL133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00341":null,"YOL133W":null},"has_protein_features":false,"name":"HRT1","ortholog_annotations":[{"gene_uniquename":"YOL133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00341","reference_uniquename":"PMID:29761456"}],"product":"RING-H2 domain core subunit of multiple ubiquitin ligase complexes; subunit of Skp1-Cullin-F-box (SCF) that tethers the Cdc34p (E2) and Cdc53p (cullin) SCF subunits, and is required for degradation of Gic2p, Far1p, Sic1p and Cln2p; subunit of the Rtt101p-Mms1p-Mms22p ubiquitin ligase that stabilizes replication forks after DNA lesions; subunit of the Cul3p-Elc1p-Ela1p ubiquitin ligase involved in Rpb1p degradation as part of transcription-coupled repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005493","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL133W"}


id: YOL134C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit","secondary_identifier":"SGD:S000005494","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL134C"}


id: YOL135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02849":null,"YOL135C":null},"has_protein_features":false,"name":"MED7","ortholog_annotations":[{"gene_uniquename":"YOL135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02849","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005495","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL135C"}


id: YOL136C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PFK27","product":"6-phosphofructo-2-kinase; catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A","secondary_identifier":"SGD:S000005496","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL136C"}


id: YOL137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BSC6","product":"Protein of unknown function with 8 putative transmembrane segments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression","secondary_identifier":"SGD:S000005497","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL137W"}


id: YOL138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04496":null,"YOL138C":null},"has_protein_features":false,"name":"RTC1","ortholog_annotations":[{"gene_uniquename":"YOL138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04496","reference_uniquename":"PMID:29761456"}],"product":"Subunit of SEACAT, a subcomplex of the SEA complex; Rtc1p, along with Mtc5p and Sea4p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; null suppresses cdc13-1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005498","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL138C"}


id: YOL139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00507":null,"SJAG_03223":null,"YOL139C":null},"has_protein_features":false,"name":"CDC33","ortholog_annotations":[{"gene_uniquename":"YOL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00507","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03223","reference_uniquename":"PMID:29761456"}],"product":"Translation initiation factor eIF4E; mRNA cap binding protein and subunit of the mRNA cap-binding complex (eIF4F) along with eIF4A (Tif1p/Tif2p) and eIF4G (Tif4631p/Tif4632p), that mediates cap-dependent translation; required with eIF4G for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; protein abundance increases in response to DNA replication stress; human homolog EIF4E can complement the cdc33 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005499","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL139C"}


id: YOL140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01019":null,"YOL140W":null},"has_protein_features":false,"name":"ARG8","ortholog_annotations":[{"gene_uniquename":"YOL140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01019","reference_uniquename":"PMID:29761456"}],"product":"Acetylornithine aminotransferase; catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005500","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL140W"}


id: YOL141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01261":null,"YOL141W":null},"has_protein_features":false,"name":"PPM2","ortholog_annotations":[{"gene_uniquename":"YOL141W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01261","reference_uniquename":"PMID:29761456"}],"product":"AdoMet-dependent tRNA methyltransferase; also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005501","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL141W"}


id: YOL142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04321":null,"YOL142W":null},"has_protein_features":false,"name":"RRP40","ortholog_annotations":[{"gene_uniquename":"YOL142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04321","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; mutations in the human homolog, EXOSC3, cause pontocerebellar hypoplasia with motor neuron degeneration","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005502","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL142W"}


id: YOL143C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02360":null,"YOL143C":null},"has_protein_features":false,"name":"RIB4","ortholog_annotations":[{"gene_uniquename":"YOL143C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02360","reference_uniquename":"PMID:29761456"}],"product":"Lumazine synthase (DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6,7-dimethyl-8-ribityllumazine synthase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005503","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL143C"}


id: YOL144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04610":null,"YOL144W":null},"has_protein_features":false,"name":"NOP8","ortholog_annotations":[{"gene_uniquename":"YOL144W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04610","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein required for 60S ribosomal subunit biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005504","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL144W"}


id: YOL145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00139":null,"YOL145C":null},"has_protein_features":false,"name":"CTR9","ortholog_annotations":[{"gene_uniquename":"YOL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00139","reference_uniquename":"PMID:29761456"}],"product":"Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005505","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL145C"}


id: YOL146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00536":null,"YOL146W":null},"has_protein_features":false,"name":"PSF3","ortholog_annotations":[{"gene_uniquename":"YOL146W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00536","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005506","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL146W"}


id: YOL147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02788":null,"SJAG_04146":null,"YOL147C":null},"has_protein_features":false,"name":"PEX11","ortholog_annotations":[{"gene_uniquename":"YOL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02788","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04146","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal protein required for medium-chain fatty acid oxidation; also required for peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005507","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL147C"}


id: YOL148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01658":null,"YOL148C":null},"has_protein_features":false,"name":"SPT20","ortholog_annotations":[{"gene_uniquename":"YOL148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01658","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SAGA transcriptional regulatory complex; involved in maintaining the integrity of the complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005508","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL148C"}


id: YOL149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05694":null,"YOL149W":null},"has_protein_features":false,"name":"DCP1","ortholog_annotations":[{"gene_uniquename":"YOL149W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05694","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005509","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL149W"}


id: YOL150C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005510","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL150C"}


id: YOL151W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02960":null,"YOL151W":null},"has_protein_features":false,"name":"GRE2","ortholog_annotations":[{"gene_uniquename":"YOL151W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02960","reference_uniquename":"PMID:29761456"}],"product":"3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005511","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL151W"}


id: YOL152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04743":null,"YOL152W":null},"has_protein_features":false,"name":"FRE7","ortholog_annotations":[{"gene_uniquename":"YOL152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005512","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL152W"}


id: YOL153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Blocked reading frame, contains two in-frame stops in translation; this ORF is conserved, without the stops, in Saccharomyces paradoxus, S. mikatae, and S. bayanus; RNA sequencing data indicate the presence of a transcription unit at this reading frame","secondary_identifier":"SGD:S000005513","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL153C"}


id: YOL154W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ZPS1","product":"Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH","secondary_identifier":"SGD:S000005514","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL154W"}


id: YOL155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HPF1","product":"Haze-protective mannoprotein; reduces particle size of aggregated proteins in white wines, thereby decreasing turbidity; intragenic repeat expansion controls chronological aging; expansion of intragenic tandem repeats within N-terminus sufficient to cause pronounced life span shortening; repeat expansion shifts cells from sedentary to buoyant, thereby increasing exposure to oxygen, altering methionine, lipid, and purine metabolism","secondary_identifier":"SGD:S000005515","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL155C"}


id: YOL155W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028855","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL155W-A"}


id: YOL156W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YOL156W":null},"has_protein_features":false,"name":"HXT11","ortholog_annotations":[{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Hexose transporter; capable of transporting a broad range of substrates including: glucose, fructose, mannose and galactose; polyol transporter that supports the growth on and uptake of xylitol with low affinity when overexpressed in a strain deleted for hexose family members; nearly identical in sequence to Hxt9p; has similarity to major facilitator superfamily (MFS) transporters; involved in pleiotropic drug resistance","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005516","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL156W"}


id: YOL157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IMA2","product":"Isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; not required for isomaltose utilization, but Ima2p overexpression allows the ima1 null mutant to grow on isomaltose","secondary_identifier":"SGD:S000005517","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL157C"}


id: YOL158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YOL158C":null},"has_protein_features":false,"name":"ENB1","ortholog_annotations":[{"gene_uniquename":"YOL158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"Ferric enterobactin transmembrane transporter; expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005518","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL158C"}


id: YOL159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CSS3","product":"Protein of unknown function, secreted when constitutively expressed; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cell periphery, SWAT-GFP fusion also localizes to the extracellular region, and mCherry fusion also localizes to the vacuole; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA","secondary_identifier":"SGD:S000005519","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL159C"}


id: YOL159C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species","secondary_identifier":"SGD:S000007627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL159C-A"}


id: YOL160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000005520","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL160W"}


id: YOL161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PAU20","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; expression induced by low temperature and also by anaerobic conditions; induced during alcoholic fermentation","secondary_identifier":"SGD:S000005521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL161C"}


id: YOL162W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; proposed to be an inactive evolutionary remnant that along with neighboring gene YOL163W may have constituted a second sulfonate transporter and SOA1 paralog that is intact in S. uvarum, S. eubayanus and S. arboricola and named SOA2; member of the Dal5p subfamily of the major facilitator family","secondary_identifier":"SGD:S000005522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL162W"}


id: YOL163W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; proposed to be an inactive evolutionary remnant that along with neighboring gene YOL162W may have constituted a second sulfonate transporter and SOA1 paralog that is intact in S. uvarum, S. eubayanus and S. arboricola and named SOA2; member of the Dal5p subfamily of the major facilitator family","secondary_identifier":"SGD:S000005523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL163W"}


id: YOL164W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BDS1","product":"Bacterially-derived sulfatase; required for use of alkyl- and aryl-sulfates as sulfur sources","secondary_identifier":"SGD:S000005524","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL164W"}


id: YOL164W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028580","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL164W-A"}


id: YOL165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AAD15","product":"Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD15 has a paralog, AAD3, that arose from a segmental duplication; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family","secondary_identifier":"SGD:S000005525","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL165C"}


id: YOL166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL166C"}


id: YOL166W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028709","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL166W-A"}


id: YOR001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03745":null,"YOR001W":null},"has_protein_features":false,"name":"RRP6","ortholog_annotations":[{"gene_uniquename":"YOR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03745","reference_uniquename":"PMID:29761456"}],"product":"Nuclear exosome exonuclease component; has 3'-5' exonuclease activity that is regulated by Lrp1p; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; role in sn/snoRNAs precursor degradation; forms a stable heterodimer with Lrp1p; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005527","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR001W"}


id: YOR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03656":null,"YOR002W":null},"has_protein_features":false,"name":"ALG6","ortholog_annotations":[{"gene_uniquename":"YOR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03656","reference_uniquename":"PMID:29761456"}],"product":"ER-luminal alpha 1,3 glucosyltransferase; involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; C998T transition in human ortholog ALG6 causes carbohydrate-deficient glycoprotein syndrome type-Ic; wild-type human ortholog ALG6 can partially complement yeast alg6 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005528","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR002W"}


id: YOR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02432":null,"SJAG_04785":null,"YOR003W":null},"has_protein_features":false,"name":"YSP3","ortholog_annotations":[{"gene_uniquename":"YOR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02432","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04785","reference_uniquename":"PMID:29761456"}],"product":"Putative precursor of the subtilisin-like protease III; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YSP3 has a paralog, PRB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005529","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR003W"}


id: YOR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00253":null,"YOR004W":null},"has_protein_features":false,"name":"UTP23","ortholog_annotations":[{"gene_uniquename":"YOR004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00253","reference_uniquename":"PMID:29761456"}],"product":"Component of the small subunit processome; involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005530","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR004W"}


id: YOR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02527":null,"YOR005C":null},"has_protein_features":false,"name":"DNL4","ortholog_annotations":[{"gene_uniquename":"YOR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02527","reference_uniquename":"PMID:29761456"}],"product":"DNA ligase required for nonhomologous end-joining (NHEJ); forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth; mutations in human ortholog lead to ligase IV syndrome and Dubowitz syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005531","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR005C"}


id: YOR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03755":null,"YOR006C":null},"has_protein_features":false,"name":"TSR3","ortholog_annotations":[{"gene_uniquename":"YOR006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03755","reference_uniquename":"PMID:29761456"}],"product":"Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005532","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR006C"}


id: YOR007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01496":null,"YOR007C":null},"has_protein_features":false,"name":"SGT2","ortholog_annotations":[{"gene_uniquename":"YOR007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01496","reference_uniquename":"PMID:29761456"}],"product":"Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; similar to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005533","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR007C"}


id: YOR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02258":null,"YOR008C":null},"has_protein_features":false,"name":"SLG1","ortholog_annotations":[{"gene_uniquename":"YOR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02258","reference_uniquename":"PMID:29761456"}],"product":"Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005534","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR008C"}


id: YOR008C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; includes a potential transmembrane domain; deletion results in slightly lengthened telomeres; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","secondary_identifier":"SGD:S000006431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR008C-A"}


id: YOR008W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR008W-B"}


id: YOR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TIR4","product":"Cell wall mannoprotein; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins","secondary_identifier":"SGD:S000005535","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR009W"}


id: YOR010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TIR2","product":"Putative cell wall mannoprotein; member of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis; TIR2 has a paralog, TIR3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005536","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR010C"}


id: YOR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04277":null,"YOR011W":null},"has_protein_features":false,"name":"AUS1","ortholog_annotations":[{"gene_uniquename":"YOR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen; AUS1 has a paralog, PDR11, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005537","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR011W"}


id: YOR011W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028581","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR011W-A"}


id: YOR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01619":null,"YOR012W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01619","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005538","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR012W"}


id: YOR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IRC11","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012W; null mutant displays increased levels of spontaneous Rad52 foci","secondary_identifier":"SGD:S000005539","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR013W"}


id: YOR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03353":null,"SJAG_03681":null,"YOR014W":null},"has_protein_features":false,"name":"RTS1","ortholog_annotations":[{"gene_uniquename":"YOR014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03353","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03681","reference_uniquename":"PMID:29761456"}],"product":"B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005540","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR014W"}


id: YOR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YOR015W is not an essential gene","secondary_identifier":"SGD:S000005541","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR015W"}


id: YOR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03270":null,"YOR016C":null},"has_protein_features":false,"name":"ERP4","ortholog_annotations":[{"gene_uniquename":"YOR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03270","reference_uniquename":"PMID:29761456"}],"product":"Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; ERP4 has a paralog, ERP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005542","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR016C"}


id: YOR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02526":null,"YOR017W":null},"has_protein_features":false,"name":"PET127","ortholog_annotations":[{"gene_uniquename":"YOR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02526","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005543","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR017W"}


id: YOR018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00803":null,"SJAG_01686":null,"YOR018W":null},"has_protein_features":false,"name":"ROD1","ortholog_annotations":[{"gene_uniquename":"YOR018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00803","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01686","reference_uniquename":"PMID:29761456"}],"product":"Alpha-arrestin involved in ubiquitin-dependent endocytosis; activating dephosphorylation relays glucose signaling to transporter endocytosis; calcineurin dephosphorylation is required for Rsp5p-dependent internalization of agonist-occupied Ste2p, as part of signal desensitization; recruits Rsp5p to Ste2p via its 2 PPXY motifs; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005544","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR018W"}


id: YOR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; YOR019W has a paralog, JIP4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005545","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR019W"}


id: YOR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01684":null,"YOR020C":null},"has_protein_features":false,"name":"HSP10","ortholog_annotations":[{"gene_uniquename":"YOR020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01684","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial matrix co-chaperonin; inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005546","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR020C"}


id: YOR020W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MCO10","product":"Mitochondrial protein of unknown function; conserved in A. gossypii; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000028526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR020W-A"}


id: YOR021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SFM1","product":"SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism","secondary_identifier":"SGD:S000005547","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR021C"}


id: YOR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00199":null,"SJAG_04292":null,"YOR022C":null},"has_protein_features":false,"name":"DDL1","ortholog_annotations":[{"gene_uniquename":"YOR022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00199","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04292","reference_uniquename":"PMID:29761456"}],"product":"DDHD domain-containing phospholipase A1; mitochondrial matrix enzyme with sn-1-specific activity, hydrolyzing cardiolipin, PE, PC, PG and PA; implicated in remodeling of mitochondrial phospholipids; antagonistically regulated by Aft1p and Aft2p; in humans, mutations in DDHD1 and DDHD2 genes cause specific types of hereditary spastic paraplegia, while DDL1-defective yeast share similar phenotypes such as mitochondrial dysfunction and defects in lipid metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005548","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR022C"}


id: YOR023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AHC1","product":"Subunit of the Ada histone acetyltransferase complex; required for structural integrity of the complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; Ahc2p may tether Ahc1p to the complex","secondary_identifier":"SGD:S000005549","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR023C"}


id: YOR024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005550","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR024W"}


id: YOR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04039":null,"YOR025W":null},"has_protein_features":false,"name":"HST3","ortholog_annotations":[{"gene_uniquename":"YOR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04039","reference_uniquename":"PMID:29761456"}],"product":"Sirtuin, histone H3 deacetylase; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; member of the Sir2 family of NAD(+)-dependent protein deacetylases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005551","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR025W"}


id: YOR026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02451":null,"YOR026W":null},"has_protein_features":false,"name":"BUB3","ortholog_annotations":[{"gene_uniquename":"YOR026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02451","reference_uniquename":"PMID:29761456"}],"product":"Kinetochore checkpoint WD40 repeat protein; localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p; functions at kinetochore to activate APC/C-Cdc20p for normal mitotic progression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005552","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR026W"}


id: YOR027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03717":null,"YOR027W":null},"has_protein_features":false,"name":"STI1","ortholog_annotations":[{"gene_uniquename":"YOR027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03717","reference_uniquename":"PMID:29761456"}],"product":"Evolutionarily-conserved Hsp90 cochaperone; regulates spatial organization of amyloid-like proteins in the cytosol, thereby buffering the proteotoxicity caused by amyloid-like proteins; interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005553","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR027W"}


id: YOR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CIN5","product":"Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005554","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR028C"}


id: YOR029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YOR029W is not an essential gene","secondary_identifier":"SGD:S000005555","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR029W"}


id: YOR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DFG16","product":"Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p","secondary_identifier":"SGD:S000005556","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR030W"}


id: YOR031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CRS5","product":"Copper-binding metallothionein; required for wild-type copper resistance","secondary_identifier":"SGD:S000005557","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR031W"}


id: YOR032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HMS1","product":"bHLH protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant","secondary_identifier":"SGD:S000005558","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR032C"}


id: YOR032W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028710","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR032W-A"}


id: YOR033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01832":null,"YOR033C":null},"has_protein_features":false,"name":"EXO1","ortholog_annotations":[{"gene_uniquename":"YOR033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01832","reference_uniquename":"PMID:29761456"}],"product":"5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair, MMS2 error-free branch of the post replication (PRR) pathway and DNA mismatch repair; role in telomere maintenance; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress; EXO1 has a paralog, DIN7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005559","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR033C"}


id: YOR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01112":null,"YOR034C":null},"has_protein_features":false,"name":"AKR2","ortholog_annotations":[{"gene_uniquename":"YOR034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01112","reference_uniquename":"PMID:29761456"}],"product":"Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005560","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR034C"}


id: YOR034C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028856","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR034C-A"}


id: YOR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00750":null,"YOR035C":null},"has_protein_features":false,"name":"SHE4","ortholog_annotations":[{"gene_uniquename":"YOR035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00750","reference_uniquename":"PMID:29761456"}],"product":"Protein containing a UCS (UNC-45/CRO1/SHE4) domain; binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005561","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR035C"}


id: YOR036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03848":null,"YOR036W":null},"has_protein_features":false,"name":"PEP12","ortholog_annotations":[{"gene_uniquename":"YOR036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03848","reference_uniquename":"PMID:29761456"}],"product":"Target membrane receptor (t-SNARE); for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005562","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR036W"}


id: YOR037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03456":null,"YOR037W":null},"has_protein_features":false,"name":"CYC2","ortholog_annotations":[{"gene_uniquename":"YOR037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03456","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial peripheral inner membrane protein; contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005563","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR037W"}


id: YOR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00913":null,"SJAG_00925":null,"YOR038C":null},"has_protein_features":false,"name":"HIR2","ortholog_annotations":[{"gene_uniquename":"YOR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00913","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00925","reference_uniquename":"PMID:29761456"}],"product":"Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005564","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR038C"}


id: YOR039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00142":null,"SJAG_03931":null,"YOR039W":null},"has_protein_features":false,"name":"CKB2","ortholog_annotations":[{"gene_uniquename":"YOR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00142","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03931","reference_uniquename":"PMID:29761456"}],"product":"Beta' regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005565","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR039W"}


id: YOR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01596":null,"YOR040W":null},"has_protein_features":false,"name":"GLO4","ortholog_annotations":[{"gene_uniquename":"YOR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01596","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO4 has a paralog, GLO2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR040W"}


id: YOR041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance","secondary_identifier":"SGD:S000005567","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR041C"}


id: YOR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05335":null,"YOR042W":null},"has_protein_features":false,"name":"CUE5","ortholog_annotations":[{"gene_uniquename":"YOR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05335","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-binding protein; functions as ubiquitin-Atg8p adaptor in ubiquitin-dependent autophagy; serves as proteaphagy receptor for inactivated 26S proteasomes; contains CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE5 has a paralog, DON1, that arose from the whole genome duplication; human TOLLIP is a functional CUE-domain homolog, can complement yeast null mutant, rescuing hypersensitivity of cue5 null mutant cells to Htt-96Q","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005568","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR042W"}


id: YOR043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01629":null,"SJAG_02687":null,"YOR043W":null},"has_protein_features":false,"name":"WHI2","ortholog_annotations":[{"gene_uniquename":"YOR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01629","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02687","reference_uniquename":"PMID:29761456"}],"product":"Negative regulator of TORC1 in response to limiting leucine; suppresses TORC1 activity with binding partners Psr1p/Psr2p, acting in parallel with SEACIT; regulates cell cycle arrest in stationary phase; inhibits Ras-cAMP-PKA regulation of apoptosis during nutrient depletion; required with Psr1p for activation of the general stress response; role in rapamycin-induced mitophagy; localizes to the cell periphery; human tumor suppressor and Whi2-like protein KCTD11 functionally complements the null","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005569","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR043W"}


id: YOR044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IRC23","product":"Protein of unknown function involved in multidrug resistance; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005570","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR044W"}


id: YOR045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TOM6","product":"Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex","secondary_identifier":"SGD:S000005571","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR045W"}


id: YOR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04480":null,"YOR046C":null},"has_protein_features":false,"name":"DBP5","ortholog_annotations":[{"gene_uniquename":"YOR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04480","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus, remodeling messenger ribonucleoprotein particles (mRNPs), with ATPase activity stimulated by Gle1p, IP6 and Nup159p; involved in translation termination along with Sup45p (eRF1); role in the cellular response to heat stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005572","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR046C"}


id: YOR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"STD1","product":"Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]; STD1 has a paralog, MTH1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005573","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR047C"}


id: YOR048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02275":null,"YOR048C":null},"has_protein_features":false,"name":"RAT1","ortholog_annotations":[{"gene_uniquename":"YOR048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02275","reference_uniquename":"PMID:29761456"}],"product":"Nuclear 5' to 3' single-stranded RNA exonuclease; involved in RNA metabolism, including rRNA and snoRNA processing, as well as poly (A+) dependent and independent mRNA transcription termination; required for cotranscriptional pre-rRNA cleavage; displaces Cdk1p from elongating transcripts, especially as RNAPII reaches the poly(A) site, negatively regulates phosphorylation of the CTD of RNAPII, and inhibits RNAPII transcriptional elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005574","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR048C"}


id: YOR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00018":null,"SJAG_00587":null,"SJAG_00589":null,"SJAG_01095":null,"SJAG_02114":null,"SJAG_02132":null,"SJAG_02581":null,"SJAG_02943":null,"SJAG_02957":null,"YOR049C":null},"has_protein_features":false,"name":"RSB1","ortholog_annotations":[{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00018","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00587","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00589","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01095","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02114","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02132","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02581","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02943","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02957","reference_uniquename":"PMID:29761456"}],"product":"Sphingoid long-chain base (LCB) efflux transporter; integral membrane transporter that localizes to the plasma membrane and may transport long chain bases (LCBs) from the cytoplasmic side toward the extracytoplasmic side of the membrane; role in glycerophospholipid translocation; suppressor of the sphingoid LCB sensitivity of an LCB-lyase mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005575","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR049C"}


id: YOR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant is viable","secondary_identifier":"SGD:S000005576","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR050C"}


id: YOR051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01150":null,"YOR051C":null},"has_protein_features":false,"name":"ETT1","ortholog_annotations":[{"gene_uniquename":"YOR051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01150","reference_uniquename":"PMID:29761456"}],"product":"Nuclear protein that inhibits replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005577","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR051C"}


id: YOR052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04129":null,"YOR052C":null},"has_protein_features":false,"name":"TMC1","ortholog_annotations":[{"gene_uniquename":"YOR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04129","reference_uniquename":"PMID:29761456"}],"product":"AN1-type zinc finger protein, effector of proteotoxic stress response; stress-inducible transcriptional target of Rpn4p; induced by nitrogen limitation, weak acid, misfolded proteins; short-lived protein, degraded by proteasome; may protect cells from trivalent metalloid induced proteotoxicity; contains PACE promoter element; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases under DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005578","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR052C"}


id: YOR053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C","secondary_identifier":"SGD:S000005579","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR053W"}


id: YOR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"VHS3","product":"Negative regulatory subunit of protein phosphatase 1 Ppz1p; involved in coenzyme A biosynthesis; subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p)","secondary_identifier":"SGD:S000005580","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR054C"}


id: YOR055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005581","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR055W"}


id: YOR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03539":null,"YOR056C":null},"has_protein_features":false,"name":"NOB1","ortholog_annotations":[{"gene_uniquename":"YOR056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03539","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005582","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR056C"}


id: YOR057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00574":null,"YOR057W":null},"has_protein_features":false,"name":"SGT1","ortholog_annotations":[{"gene_uniquename":"YOR057W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00574","reference_uniquename":"PMID:29761456"}],"product":"Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005583","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR057W"}


id: YOR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00723":null,"SJAG_03073":null,"YOR058C":null},"has_protein_features":false,"name":"ASE1","ortholog_annotations":[{"gene_uniquename":"YOR058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00723","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03073","reference_uniquename":"PMID:29761456"}],"product":"Mitotic spindle midzone-localized microtubule bundling protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005584","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR058C"}


id: YOR059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04973":null,"YOR059C":null},"has_protein_features":false,"name":"LPL1","ortholog_annotations":[{"gene_uniquename":"YOR059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04973","reference_uniquename":"PMID:29761456"}],"product":"Phospholipase; contains lipase specific GXSXG motif; maintains lipid droplet (LD) morphology; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005585","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR059C"}


id: YOR060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SLD7","product":"Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria; ortholog of human MTBP, which is a DNA replication origin firing factor","secondary_identifier":"SGD:S000005586","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR060C"}


id: YOR061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01799":null,"YOR061W":null},"has_protein_features":false,"name":"CKA2","ortholog_annotations":[{"gene_uniquename":"YOR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01799","reference_uniquename":"PMID:29761456"}],"product":"Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR061W"}


id: YOR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; similar to Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; YOR062C has a paralog, YKR075C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005588","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR062C"}


id: YOR063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01322":null,"SJAG_02611":null,"YOR063W":null},"has_protein_features":false,"name":"RPL3","ortholog_annotations":[{"gene_uniquename":"YOR063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01322","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02611","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; plays an important role in function of eIF5B in stimulating 3' end processing of 18S rRNA in context of 80S ribosomes that have not yet engaged in translation; involved in replication and maintenance of killer double stranded RNA virus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005589","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR063W"}


id: YOR064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03230":null,"SJAG_03628":null,"YOR064C":null},"has_protein_features":false,"name":"YNG1","ortholog_annotations":[{"gene_uniquename":"YOR064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03230","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03628","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3; shares significant sequence identity with the human candidate tumor suppressor p33-ING1 in C-terminal region","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005590","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR064C"}


id: YOR065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02646":null,"YOR065W":null},"has_protein_features":false,"name":"CYT1","ortholog_annotations":[{"gene_uniquename":"YOR065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02646","reference_uniquename":"PMID:29761456"}],"product":"Cytochrome c1; component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005591","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR065W"}


id: YOR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MSA1","product":"Activator of G1-specific transcription factors MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; MSA1 has a paralog, MSA2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005592","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR066W"}


id: YOR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01950":null,"YOR067C":null},"has_protein_features":false,"name":"ALG8","ortholog_annotations":[{"gene_uniquename":"YOR067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01950","reference_uniquename":"PMID:29761456"}],"product":"Glucosyl transferase; involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p; human homolog ALG8 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005593","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR067C"}


id: YOR068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"VAM10","product":"Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering","secondary_identifier":"SGD:S000005594","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR068C"}


id: YOR069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01382":null,"SJAG_04275":null,"YOR069W":null},"has_protein_features":false,"name":"VPS5","ortholog_annotations":[{"gene_uniquename":"YOR069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01382","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOR069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04275","reference_uniquename":"PMID:29761456"}],"product":"Nexin-1 homolog; required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to late Golgi; structural component of retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes; VPS5 has a paralog, YKR078W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005595","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR069W"}


id: YOR070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04548":null,"YOR070C":null},"has_protein_features":false,"name":"GYP1","ortholog_annotations":[{"gene_uniquename":"YOR070C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04548","reference_uniquename":"PMID:29761456"}],"product":"Cis-golgi GTPase-activating protein (GAP) for yeast Rabs; the Rab family members are Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion; interacts with autophagosome component Atg8p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005596","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR070C"}


id: YOR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"NRT1","product":"High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; major transporter for 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine) uptake; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity","secondary_identifier":"SGD:S000005597","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR071C"}


id: YOR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive","secondary_identifier":"SGD:S000005598","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR072W"}


id: YOR072W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028582","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR072W-A"}


id: YOR072W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028516","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR072W-B"}


id: YOR073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03989":null,"SJAG_04623":null,"YOR073W":null},"has_protein_features":false,"name":"SGO1","ortholog_annotations":[{"gene_uniquename":"YOR073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03989","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04623","reference_uniquename":"PMID:29761456"}],"product":"Component of the spindle checkpoint; involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; recruits condensin to the pericentric region of chromosomes during meiosis; dissociates from pericentromeres when sister kinetochores are under tension","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005599","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR073W"}


id: YOR073W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CDC21/YOR074C; identified by RT-PCR","secondary_identifier":"SGD:S000028583","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR073W-A"}


id: YOR074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04627":null,"YOR074C":null},"has_protein_features":false,"name":"CDC21","ortholog_annotations":[{"gene_uniquename":"YOR074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04627","reference_uniquename":"PMID:29761456"}],"product":"Thymidylate synthase; required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S; human homolog TYMSOS can complement yeast cdc21 temperature-sensitive mutant at restrictive temperature","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005600","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR074C"}


id: YOR075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04701":null,"YOR075W":null},"has_protein_features":false,"name":"UFE1","ortholog_annotations":[{"gene_uniquename":"YOR075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04701","reference_uniquename":"PMID:29761456"}],"product":"t-SNARE protein required for retrograde vesicular traffic; involved in Sey1p-independent homotypic ER fusion; required for efficient nuclear fusion during mating; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005601","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR075W"}


id: YOR076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00226":null,"YOR076C":null},"has_protein_features":false,"name":"SKI7","ortholog_annotations":[{"gene_uniquename":"YOR076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00226","reference_uniquename":"PMID:29761456"}],"product":"GTP-binding protein that couples the Ski complex and exosome; putative pseudo-translational GTPase involved in 3'-to-5' mRNA decay pathway; interacts with both the cytoplasmic exosome and the Ski complex; eRF3-like domain targets nonstop mRNA for degradation; null mutants have a superkiller phenotype; SKI7 has a paralog, HBS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005602","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR076C"}


id: YOR077W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03840":null,"YOR077W":null},"has_protein_features":false,"name":"RTS2","ortholog_annotations":[{"gene_uniquename":"YOR077W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03840","reference_uniquename":"PMID:29761456"}],"product":"Basic zinc-finger protein; similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005603","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR077W"}


id: YOR078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02662":null,"YOR078W":null},"has_protein_features":false,"name":"BUD21","ortholog_annotations":[{"gene_uniquename":"YOR078W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02662","reference_uniquename":"PMID:29761456"}],"product":"Component of small ribosomal subunit (SSU) processosome; this complex contains U3 snoRNA; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; originally isolated as bud-site selection mutant that displays a random budding pattern","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005604","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR078W"}


id: YOR079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATX2","product":"Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation","secondary_identifier":"SGD:S000005605","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR079C"}


id: YOR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01068":null,"YOR080W":null},"has_protein_features":false,"name":"DIA2","ortholog_annotations":[{"gene_uniquename":"YOR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01068","reference_uniquename":"PMID:29761456"}],"product":"Origin-binding F-box protein; forms SCF ubiquitin ligase complex with Skp1p and Cdc53p; functions in ubiquitination of silent chromatin structural protein Sir4p; required to target Cdc6p for destruction during G1 phase; required for deactivation of Rad53 checkpoint kinase, completion of DNA replication during recovery from DNA damage, assembly of RSC complex, RSC-mediated transcription regulation, and nucleosome positioning; involved in invasive and pseudohyphal growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005606","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR080W"}


id: YOR081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02089":null,"SJAG_02907":null,"YOR081C":null},"has_protein_features":false,"name":"TGL5","ortholog_annotations":[{"gene_uniquename":"YOR081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02089","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02907","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional triacylglycerol lipase and LPA acyltransferase; lipid particle-localized triacylglycerol (TAG) lipase involved in triacylglycerol mobilization; catalyzes acylation of lysophosphatidic acid (LPA); potential Cdc28p substrate; TGL5 has a paralog, TGL4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005607","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR081C"}


id: YOR082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR083W","secondary_identifier":"SGD:S000005608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR082C"}


id: YOR083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03845":null,"YOR083W":null},"has_protein_features":false,"name":"WHI5","ortholog_annotations":[{"gene_uniquename":"YOR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03845","reference_uniquename":"PMID:29761456"}],"product":"Repressor of G1 transcription; binds to SCB binding factor (SBF) at SCB target promoters in early G1; dilution of Whi5p concentration during cell growth determines cell size; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5, and contributes to both the determination of critical cell size at START and cell fate; periodically expressed in G1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR083W"}


id: YOR084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"LPX1","product":"Peroxisomal matrix-localized lipase; required for normal peroxisome morphology; contains a peroxisomal targeting signal type 1 (PTS1) and a lipase motif; peroxisomal import requires the PTS1 receptor, Pex5p and self-interaction; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; oleic acid inducible","secondary_identifier":"SGD:S000005610","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR084W"}


id: YOR085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03333":null,"YOR085W":null},"has_protein_features":false,"name":"OST3","ortholog_annotations":[{"gene_uniquename":"YOR085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03333","reference_uniquename":"PMID:29761456"}],"product":"Gamma subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins including modification of Pmt2p at N131 and N403","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005611","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR085W"}


id: YOR086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01437":null,"SJAG_04413":null,"SJAG_04417":null,"YOR086C":null},"has_protein_features":false,"name":"TCB1","ortholog_annotations":[{"gene_uniquename":"YOR086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01437","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04413","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04417","reference_uniquename":"PMID:29761456"}],"product":"Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in PM; contains 3 calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact; TCB1 has a paralog, TCB2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005612","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR086C"}


id: YOR087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YVC1","product":"Vacuolar cation channel; mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock","secondary_identifier":"SGD:S000005613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR087W"}


id: YOR088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YOR088W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YOR087W","secondary_identifier":"SGD:S000005614","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR088W"}


id: YOR089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01379":null,"YOR089C":null},"has_protein_features":false,"name":"VPS21","ortholog_annotations":[{"gene_uniquename":"YOR089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01379","reference_uniquename":"PMID:29761456"}],"product":"Endosomal Rab family GTPase; required for endocytic transport and sorting of vacuolar hydrolases; required for endosomal localization of the CORVET complex; required with YPT52 for MVB biogenesis and sorting; involved in autophagy and ionic stress tolerance; geranylgeranylation required for membrane association; protein abundance increases in response to DNA replication stress; mammalian Rab5 homolog; VPS21 has a paralog, YPT53, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005615","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR089C"}


id: YOR090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03310":null,"YOR090C":null},"has_protein_features":false,"name":"PTC5","ortholog_annotations":[{"gene_uniquename":"YOR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03310","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial type 2C protein phosphatase (PP2C); involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005616","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR090C"}


id: YOR091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01715":null,"YOR091W":null},"has_protein_features":false,"name":"TMA46","ortholog_annotations":[{"gene_uniquename":"YOR091W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01715","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005617","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR091W"}


id: YOR092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ECM3","product":"Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005618","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR092W"}


id: YOR093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00982":null,"SJAG_03731":null,"YOR093C":null},"has_protein_features":false,"name":"CMR2","ortholog_annotations":[{"gene_uniquename":"YOR093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00982","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03731","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR093C"}


id: YOR094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01456":null,"YOR094W":null},"has_protein_features":false,"name":"ARF3","ortholog_annotations":[{"gene_uniquename":"YOR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01456","reference_uniquename":"PMID:29761456"}],"product":"Glucose-repressible ADP-ribosylation factor; GTPase of Ras superfamily involved in regulating cell polarity and invasive growth; localizes to dynamic spots at plasma membrane and modulates PtdIns(4,5)P2 levels to facilitate endocytosis; required for localization of endocytic protein Lsb5p to correct cortical site in cells; also has mRNA binding activity; homolog of mammalian Arf6","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005620","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR094W"}


id: YOR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00070":null,"YOR095C":null},"has_protein_features":false,"name":"RKI1","ortholog_annotations":[{"gene_uniquename":"YOR095C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00070","reference_uniquename":"PMID:29761456"}],"product":"Ribose-5-phosphate ketol-isomerase; catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005621","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR095C"}


id: YOR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02046":null,"YOR096W":null},"has_protein_features":false,"name":"RPS7A","ortholog_annotations":[{"gene_uniquename":"YOR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02046","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005622","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR096W"}


id: YOR097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene","secondary_identifier":"SGD:S000005623","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR097C"}


id: YOR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03729":null,"YOR098C":null},"has_protein_features":false,"name":"NUP1","ortholog_annotations":[{"gene_uniquename":"YOR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03729","reference_uniquename":"PMID:29761456"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of thenuclear pore complex (NPC) permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005624","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR098C"}


id: YOR099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"YOR099W":null},"has_protein_features":false,"name":"KTR1","ortholog_annotations":[{"gene_uniquename":"YOR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"}],"product":"Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005625","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR099W"}


id: YOR100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00543":null,"YOR100C":null},"has_protein_features":false,"name":"CRC1","ortholog_annotations":[{"gene_uniquename":"YOR100C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00543","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homolog SLC25A20 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR100C"}


id: YOR101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03453":null,"YOR101W":null},"has_protein_features":false,"name":"RAS1","ortholog_annotations":[{"gene_uniquename":"YOR101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03453","reference_uniquename":"PMID:29761456"}],"product":"GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in regulation of cell proliferation; localized to the plasma membrane; activated by increased levels of glycolysis intermediate fructose-1,6-bisphosphate; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress; RAS1 has a paralog, RAS2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR101W"}


id: YOR102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex","secondary_identifier":"SGD:S000005628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR102W"}


id: YOR103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01389":null,"YOR103C":null},"has_protein_features":false,"name":"OST2","ortholog_annotations":[{"gene_uniquename":"YOR103C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01389","reference_uniquename":"PMID:29761456"}],"product":"Epsilon subunit of the oligosaccharyltransferase complex; located in the ER lumen; catalyzes asparagine-linked glycosylation of newly synthesized proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR103C"}


id: YOR104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PIN2","product":"Exomer-dependent cargo protein; induces appearance of [PIN+] prion when overproduced; prion-like domain serves as a retention signal in the trans-Golgi network; predicted to be palmitoylated","secondary_identifier":"SGD:S000005630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR104W"}


id: YOR105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels","secondary_identifier":"SGD:S000005631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR105W"}


id: YOR106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"VAM3","product":"Syntaxin-like vacuolar t-SNARE; functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region","secondary_identifier":"SGD:S000005632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR106W"}


id: YOR107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RGS2","product":"Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p","secondary_identifier":"SGD:S000005633","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR107W"}


id: YOR108C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028711","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR108C-A"}


id: YOR108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02841":null,"YOR108W":null},"has_protein_features":false,"name":"LEU9","ortholog_annotations":[{"gene_uniquename":"YOR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02841","reference_uniquename":"PMID:29761456"}],"product":"Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005634","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR108W"}


id: YOR109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00063":null,"SJAG_03375":null,"YOR109W":null},"has_protein_features":false,"name":"INP53","ortholog_annotations":[{"gene_uniquename":"YOR109W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00063","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR109W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03375","reference_uniquename":"PMID:29761456"}],"product":"Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; INP53 has a paralog, INP52, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005635","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR109W"}


id: YOR110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05339":null,"YOR110W":null},"has_protein_features":false,"name":"TFC7","ortholog_annotations":[{"gene_uniquename":"YOR110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05339","reference_uniquename":"PMID:29761456"}],"product":"RNA pol III transcription initiation factor complex (TFIIIC) subunit; part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; TFC7 has a paralog, YNL108C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005636","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR110W"}


id: YOR111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01651":null,"YOR111W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01651","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005637","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR111W"}


id: YOR112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04622":null,"YOR112W":null},"has_protein_features":false,"name":"CEX1","ortholog_annotations":[{"gene_uniquename":"YOR112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04622","reference_uniquename":"PMID:29761456"}],"product":"Component of nuclear aminoacylation-dependent tRNA export pathway; cytoplasmic; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a; required for activation of RAN GTPase Gsp1p and dissociation of receptor-tRNA-Gsp1p export complex; recruits Rna1p from cytoplasm to NPC, facilitates Rna1p activation of Gsp1p GTPase activity by enabling Rna1p to gain access to Gsp1p-GTP bound to export receptor tRNA complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR112W"}


id: YOR113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AZF1","product":"Zinc-finger transcription factor; involved in the diauxic shift; activates transcription of genes involved in carbon metabolism and energy production on glucose, while it activates transcription of genes involved in cell wall organization and biogenesis on glycerol-lactate; may also function as a co-repressor; capable of forming the prion [AZF1+]; relocalizes to the cytosol in response to hypoxia; contains polyglutamine and polyasparagine domains","secondary_identifier":"SGD:S000005639","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR113W"}


id: YOR114W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DPI34","product":"Putative mitochondrial protein of unknown function; null mutant is viable","secondary_identifier":"SGD:S000005640","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR114W"}


id: YOR115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02525":null,"YOR115C":null},"has_protein_features":false,"name":"TRS33","ortholog_annotations":[{"gene_uniquename":"YOR115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02525","reference_uniquename":"PMID:29761456"}],"product":"Core component of TRAPP complexes I, II and IV; transport protein particle (TRAPP) complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII, and IV); proposed subunit of a novel complex, TRAPPIV, that may function redundantly with TRAPPIII as a GEF that activates Ypt1 during autophagy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005641","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR115C"}


id: YOR116C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04934":null,"YOR116C":null},"has_protein_features":false,"name":"RPO31","ortholog_annotations":[{"gene_uniquename":"YOR116C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04934","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase III largest subunit C160; part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR116C"}


id: YOR117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01544":null,"YOR117W":null},"has_protein_features":false,"name":"RPT5","ortholog_annotations":[{"gene_uniquename":"YOR117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01544","reference_uniquename":"PMID:29761456"}],"product":"ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR117W"}


id: YOR118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03620":null,"YOR118W":null},"has_protein_features":false,"name":"RTC5","ortholog_annotations":[{"gene_uniquename":"YOR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03620","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR118W"}


id: YOR119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05018":null,"YOR119C":null},"has_protein_features":false,"name":"RIO1","ortholog_annotations":[{"gene_uniquename":"YOR119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05018","reference_uniquename":"PMID:29761456"}],"product":"Serine kinase involved in cell cycle regulation and rDNA integrity; associated with late pre-40S particles via its conserved C-terminal domain; prevents premature use of pre-40S particles in translation; association with pre-40S particles regulated by its catalytic ATPase site and likely occurs after the release of Rio2p from these particles; involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA; phosphorylates Rpa43p in anaphase to remove Pol I from rDNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR119C"}


id: YOR120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02010":null,"YOR120W":null},"has_protein_features":false,"name":"GCY1","ortholog_annotations":[{"gene_uniquename":"YOR120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02010","reference_uniquename":"PMID:29761456"}],"product":"Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; human homolog AKR1B1 can complement yeast null mutant; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR120W"}


id: YOR121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W","secondary_identifier":"SGD:S000005647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR121C"}


id: YOR122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04982":null,"YOR122C":null},"has_protein_features":false,"name":"PFY1","ortholog_annotations":[{"gene_uniquename":"YOR122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04982","reference_uniquename":"PMID:29761456"}],"product":"Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress; highly conserved protein; human PFN1 (profilin 1) complements temperature sensitive pfy1 mutants, PFN1 mutations are a rare cause of ALS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005648","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR122C"}


id: YOR123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03118":null,"YOR123C":null},"has_protein_features":false,"name":"LEO1","ortholog_annotations":[{"gene_uniquename":"YOR123C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03118","reference_uniquename":"PMID:29761456"}],"product":"Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005649","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR123C"}


id: YOR124C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01528":null,"YOR124C":null},"has_protein_features":false,"name":"UBP2","ortholog_annotations":[{"gene_uniquename":"YOR124C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01528","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; controls K63 homeostasis during oxidative stress; deubiquitinates Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005650","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR124C"}


id: YOR125C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00459":null,"YOR125C":null},"has_protein_features":false,"name":"CAT5","ortholog_annotations":[{"gene_uniquename":"YOR125C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00459","reference_uniquename":"PMID:29761456"}],"product":"Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR125C"}


id: YOR126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01989":null,"YOR126C":null},"has_protein_features":false,"name":"IAH1","ortholog_annotations":[{"gene_uniquename":"YOR126C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01989","reference_uniquename":"PMID:29761456"}],"product":"Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR126C"}


id: YOR127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04522":null,"SJAG_04765":null,"YOR127W":null},"has_protein_features":false,"name":"RGA1","ortholog_annotations":[{"gene_uniquename":"YOR127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04522","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04765","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP); required for proper bud site selection; transiently localizes to previous cell division sites (bud scars; cytokinesis remnants), interacting with Nis1p and Nba1p, to prevent Cdc42p repolarization; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from the bud neck to cytoplasm upon DNA replication stress; contains N-terminal LIM domains and a C-terminal GAP domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005653","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR127W"}


id: YOR128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01081":null,"YOR128C":null},"has_protein_features":false,"name":"ADE2","ortholog_annotations":[{"gene_uniquename":"YOR128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01081","reference_uniquename":"PMID:29761456"}],"product":"Phosphoribosylaminoimidazole carboxylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005654","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR128C"}


id: YOR129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AFI1","product":"Arf3p polarization-specific docking factor; required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p","secondary_identifier":"SGD:S000005655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR129C"}


id: YOR130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00543":null,"YOR130C":null},"has_protein_features":false,"name":"ORT1","ortholog_annotations":[{"gene_uniquename":"YOR130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00543","reference_uniquename":"PMID:29761456"}],"product":"Ornithine transporter of the mitochondrial inner membrane; exports ornithine from mitochondria as part of arginine biosynthesis; functionally complemented by human ortholog, SLC25A15, which is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome, but HHH-associated variants fail to complement","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR130C"}


id: YOR131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000005657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR131C"}


id: YOR132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00971":null,"YOR132W":null},"has_protein_features":false,"name":"VPS17","ortholog_annotations":[{"gene_uniquename":"YOR132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00971","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the membrane-associated retromer complex; essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR132W"}


id: YOR133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01438":null,"SJAG_05332":null,"YOR133W":null},"has_protein_features":false,"name":"EFT1","ortholog_annotations":[{"gene_uniquename":"YOR133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01438","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05332","reference_uniquename":"PMID:29761456"}],"product":"Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR133W"}


id: YOR134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04462":null,"YOR134W":null},"has_protein_features":false,"name":"BAG7","ortholog_annotations":[{"gene_uniquename":"YOR134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04462","reference_uniquename":"PMID:29761456"}],"product":"Rho GTPase activating protein (RhoGAP); stimulates the intrinsic GTPase activity of Rho1p, which plays a bud growth by regulating actin cytoskeleton organization and cell wall biosynthesis, resulting in the downregulation of Rho1p; structurally and functionally related to Sac7p; BAG7 has a paralog, SAC7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR134W"}


id: YOR135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IRC14","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci","secondary_identifier":"SGD:S000005661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR135C"}


id: YOR136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IDH2","product":"Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated","secondary_identifier":"SGD:S000005662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR136W"}


id: YOR137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04262":null,"YOR137C":null},"has_protein_features":false,"name":"SIA1","ortholog_annotations":[{"gene_uniquename":"YOR137C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04262","reference_uniquename":"PMID:29761456"}],"product":"Protein of unassigned function; involved in activation of the Pma1p plasma membrane H+-ATPase by glucose; contains peptide signal for membrane localization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005663","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR137C"}


id: YOR138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01342":null,"YOR138C":null},"has_protein_features":false,"name":"RUP1","ortholog_annotations":[{"gene_uniquename":"YOR138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01342","reference_uniquename":"PMID:29761456"}],"product":"Protein that regulates ubiquitination of Rsp5p; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005664","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR138C"}


id: YOR139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W","secondary_identifier":"SGD:S000005665","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR139C"}


id: YOR140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02472":null,"SJAG_04388":null,"YOR140W":null},"has_protein_features":false,"name":"SFL1","ortholog_annotations":[{"gene_uniquename":"YOR140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02472","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04388","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; has direct role in INO1 transcriptional memory; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p; premature stop codon (C1430T, Q477-stop) in SK1 background is linked to the aggressively invasive phenotype of SK1 relative to BY4741 (S288C)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005666","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR140W"}


id: YOR141C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01611":null,"YOR141C":null},"has_protein_features":false,"name":"ARP8","ortholog_annotations":[{"gene_uniquename":"YOR141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01611","reference_uniquename":"PMID:29761456"}],"product":"Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; has mRNA binding activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005667","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR141C"}


id: YOR142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01524":null,"YOR142W":null},"has_protein_features":false,"name":"LSC1","ortholog_annotations":[{"gene_uniquename":"YOR142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01524","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005668","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR142W"}


id: YOR143C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03362":null,"YOR143C":null},"has_protein_features":false,"name":"THI80","ortholog_annotations":[{"gene_uniquename":"YOR143C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03362","reference_uniquename":"PMID:29761456"}],"product":"Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR143C"}


id: YOR144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04150":null,"YOR144C":null},"has_protein_features":false,"name":"ELG1","ortholog_annotations":[{"gene_uniquename":"YOR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04150","reference_uniquename":"PMID:29761456"}],"product":"Subunit of an alternative replication factor C complex; important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005670","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR144C"}


id: YOR145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03872":null,"YOR145C":null},"has_protein_features":false,"name":"PNO1","ortholog_annotations":[{"gene_uniquename":"YOR145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03872","reference_uniquename":"PMID:29761456"}],"product":"Essential nucleolar protein required for pre-18S rRNA processing; interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR145C"}


id: YOR146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C","secondary_identifier":"SGD:S000005672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR146W"}


id: YOR147W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03395":null,"YOR147W":null},"has_protein_features":false,"name":"MDM32","ortholog_annotations":[{"gene_uniquename":"YOR147W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03395","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein with similarity to Mdm31p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34; variation between SK1 and S288C at residues 182 and 262 impacts invasive growth and mitochondrial network structure","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR147W"}


id: YOR148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01557":null,"YOR148C":null},"has_protein_features":false,"name":"SPP2","ortholog_annotations":[{"gene_uniquename":"YOR148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01557","reference_uniquename":"PMID:29761456"}],"product":"Essential protein that promotes the first step of splicing; required for the final stages of spliceosome maturation and activation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction; stimulates Prp2p ATPase activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005674","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR148C"}


id: YOR149C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03878":null,"YOR149C":null},"has_protein_features":false,"name":"SMP3","ortholog_annotations":[{"gene_uniquename":"YOR149C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03878","reference_uniquename":"PMID:29761456"}],"product":"Alpha 1,2-mannosyltransferase; involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005675","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR149C"}


id: YOR150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03176":null,"YOR150W":null},"has_protein_features":false,"name":"MRPL23","ortholog_annotations":[{"gene_uniquename":"YOR150W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03176","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR150W"}


id: YOR151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04030":null,"YOR151C":null},"has_protein_features":false,"name":"RPB2","ortholog_annotations":[{"gene_uniquename":"YOR151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04030","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR151C"}


id: YOR152C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ATG40","product":"Autophagy receptor with a role in endoplasmic reticulum degradation; involved specifically in autophagy of cortical and cytoplasmic ER in response to nitrogen starvation or rapamycin treatment; acts with COPII subunit Sfb3p; localizes to the cortical and cytoplasmic ER; similar to human FAM134B, which is also involved in ER autophagy and is associated with sensory neuropathy","secondary_identifier":"SGD:S000005678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR152C"}


id: YOR153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04277":null,"YOR153W":null},"has_protein_features":false,"name":"PDR5","ortholog_annotations":[{"gene_uniquename":"YOR153W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth; PDR5 has a paralog, PDR15, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005679","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR153W"}


id: YOR154W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02032":null,"YOR154W":null},"has_protein_features":false,"name":"SLP1","ortholog_annotations":[{"gene_uniquename":"YOR154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02032","reference_uniquename":"PMID:29761456"}],"product":"Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005680","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR154W"}


id: YOR155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03096":null,"YOR155C":null},"has_protein_features":false,"name":"ISN1","ortholog_annotations":[{"gene_uniquename":"YOR155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03096","reference_uniquename":"PMID:29761456"}],"product":"Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase; catalyzes the breakdown of IMP to inosine; responsible for production of nicotinamide riboside and nicotinic acid riboside; expression positively regulated by nicotinic acid and glucose availability; does not show similarity to known 5'-nucleotidases from other organisms","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005681","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR155C"}


id: YOR156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00727":null,"YOR156C":null},"has_protein_features":false,"name":"NFI1","ortholog_annotations":[{"gene_uniquename":"YOR156C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00727","reference_uniquename":"PMID:29761456"}],"product":"SUMO E3 ligase; catalyzes sumoylation of Yku70p/80p and Sir4p promoting telomere anchoring to the nuclear envelope and regulating telomerase activity; DNA-bound form catalyzes a DNA-damaged triggered sumoylation wave resulting in multisite modification of several DNA repair proteins, enhancing interactions between these proteins and accelerating repair; sumoylates Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; role in telomere length maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005682","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR156C"}


id: YOR157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01014":null,"YOR157C":null},"has_protein_features":false,"name":"PUP1","ortholog_annotations":[{"gene_uniquename":"YOR157C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01014","reference_uniquename":"PMID:29761456"}],"product":"Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005683","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR157C"}


id: YOR158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00148":null,"YOR158W":null},"has_protein_features":false,"name":"PET123","ortholog_annotations":[{"gene_uniquename":"YOR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00148","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR158W"}


id: YOR159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03469":null,"YOR159C":null},"has_protein_features":false,"name":"SME1","ortholog_annotations":[{"gene_uniquename":"YOR159C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03469","reference_uniquename":"PMID:29761456"}],"product":"Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005685","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR159C"}


id: YOR160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03470":null,"YOR160W":null},"has_protein_features":false,"name":"MTR10","ortholog_annotations":[{"gene_uniquename":"YOR160W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03470","reference_uniquename":"PMID:29761456"}],"product":"Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005686","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR160W"}


id: YOR161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00763":null,"YOR161C":null},"has_protein_features":false,"name":"PNS1","ortholog_annotations":[{"gene_uniquename":"YOR161C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00763","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005687","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR161C"}


id: YOR161C-C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028712","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR161C-C"}


id: YOR161W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028713","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR161W-A"}


id: YOR161W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028714","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR161W-B"}


id: YOR162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YRR1","product":"Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005688","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR162C"}


id: YOR163W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04870":null,"YOR163W":null},"has_protein_features":false,"name":"DDP1","ortholog_annotations":[{"gene_uniquename":"YOR163W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04870","reference_uniquename":"PMID:29761456"}],"product":"Diadenosine and diphosphoinositol polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005689","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR163W"}


id: YOR164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03865":null,"YOR164C":null},"has_protein_features":false,"name":"GET4","ortholog_annotations":[{"gene_uniquename":"YOR164C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03865","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005690","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR164C"}


id: YOR165W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02595":null,"YOR165W":null},"has_protein_features":false,"name":"SEY1","ortholog_annotations":[{"gene_uniquename":"YOR165W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02595","reference_uniquename":"PMID:29761456"}],"product":"Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005691","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR165W"}


id: YOR166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04198":null,"YOR166C":null},"has_protein_features":false,"name":"SWT1","ortholog_annotations":[{"gene_uniquename":"YOR166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04198","reference_uniquename":"PMID:29761456"}],"product":"RNA endoribonuclease involved in perinuclear mRNP quality control; involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005692","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR166C"}


id: YOR167C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02749":null,"SJAG_04746":null,"YOR167C":null},"has_protein_features":false,"name":"RPS28A","ortholog_annotations":[{"gene_uniquename":"YOR167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02749","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04746","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; has an extraribosomal function in regulation of RPS28B, in which Rps28Ap binds to a decapping complex via Edc3p, which then binds to RPS28B mRNA leading to its decapping and degradation; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28A has a paralog, RPS28B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005693","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR167C"}


id: YOR168W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04482":null,"YOR168W":null},"has_protein_features":false,"name":"GLN4","ortholog_annotations":[{"gene_uniquename":"YOR168W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04482","reference_uniquename":"PMID:29761456"}],"product":"Glutamine tRNA synthetase; monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Gln); N-terminal domain proposed to be involved in enzyme-tRNA interactions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005694","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR168W"}


id: YOR169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W","secondary_identifier":"SGD:S000005695","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR169C"}


id: YOR170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4","secondary_identifier":"SGD:S000005696","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR170W"}


id: YOR171C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02429":null,"YOR171C":null},"has_protein_features":false,"name":"LCB4","ortholog_annotations":[{"gene_uniquename":"YOR171C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02429","reference_uniquename":"PMID:29761456"}],"product":"Sphingoid long-chain base kinase; responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes; LCB4 has a paralog, LCB5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005697","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR171C"}


id: YOR172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"YRM1","product":"Zinc finger transcription factor involved in multidrug resistance; Zn(2)-Cys(6) zinc finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes","secondary_identifier":"SGD:S000005698","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR172W"}


id: YOR173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01625":null,"YOR173W":null},"has_protein_features":false,"name":"DCS2","ortholog_annotations":[{"gene_uniquename":"YOR173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01625","reference_uniquename":"PMID:29761456"}],"product":"m(7)GpppX pyrophosphatase regulator; non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance; DCS2 has a paralog, DCS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005699","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR173W"}


id: YOR174W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00297":null,"YOR174W":null},"has_protein_features":false,"name":"MED4","ortholog_annotations":[{"gene_uniquename":"YOR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00297","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005700","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR174W"}


id: YOR175C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04792":null,"YOR175C":null},"has_protein_features":false,"name":"ALE1","ortholog_annotations":[{"gene_uniquename":"YOR175C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04792","reference_uniquename":"PMID:29761456"}],"product":"Broad-specificity lysophospholipid acyltransferase; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005701","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR175C"}


id: YOR176W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01841":null,"YOR176W":null},"has_protein_features":false,"name":"HEM15","ortholog_annotations":[{"gene_uniquename":"YOR176W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01841","reference_uniquename":"PMID:29761456"}],"product":"Ferrochelatase; a mitochondrial inner membrane protein, catalyzes insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; human homolog FECH can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005702","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR176W"}


id: YOR177C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MPC54","product":"Component of the meiotic outer plaque; a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate","secondary_identifier":"SGD:S000005703","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR177C"}


id: YOR178C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GAC1","product":"Regulatory subunit for Glc7p type-1 protein phosphatase (PP1); tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock; GAC1 has a paralog, PIG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR178C"}


id: YOR179C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SYC1","product":"Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005705","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR179C"}


id: YOR180C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DCI1","product":"Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed; DCI1 has a paralog, ECI1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005706","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR180C"}


id: YOR181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01732":null,"YOR181W":null},"has_protein_features":false,"name":"LAS17","ortholog_annotations":[{"gene_uniquename":"YOR181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01732","reference_uniquename":"PMID:29761456"}],"product":"Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments, polyproline domain nucleates actin filaments independent of Arp2/3; mutants are defective in endocytosis, bud site selection, cytokinesis; human homolog WAS (Wiskott-Aldrich Syndrome) implicated in severe immunodeficiency; human WAS complements yeast null mutant, but only in presence of WIPF1, which mediates localization of WAS to cortical patches","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005707","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR181W"}


id: YOR182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01287":null,"SJAG_02224":null,"YOR182C":null},"has_protein_features":false,"name":"RPS30B","ortholog_annotations":[{"gene_uniquename":"YOR182C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01287","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR182C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02224","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30B has a paralog, RPS30A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005708","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR182C"}


id: YOR183W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FYV12","product":"Protein of unknown function; required for survival upon exposure to K1 killer toxin","secondary_identifier":"SGD:S000005709","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR183W"}


id: YOR184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02791":null,"YOR184W":null},"has_protein_features":false,"name":"SER1","ortholog_annotations":[{"gene_uniquename":"YOR184W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02791","reference_uniquename":"PMID:29761456"}],"product":"3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005710","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR184W"}


id: YOR185C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01449":null,"YOR185C":null},"has_protein_features":false,"name":"GSP2","ortholog_annotations":[{"gene_uniquename":"YOR185C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01449","reference_uniquename":"PMID:29761456"}],"product":"GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); not required for viability; protein abundance increases in response to DNA replication stress; GSP2 has a paralog, GSP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005711","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR185C"}


id: YOR186C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028715","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR186C-A"}


id: YOR186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; mCherry fusion protein localizes to the vacuole; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005712","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR186W"}


id: YOR187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03461":null,"YOR187W":null},"has_protein_features":false,"name":"TUF1","ortholog_annotations":[{"gene_uniquename":"YOR187W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03461","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial translation elongation factor Tu (EF-Tu); involved in fundamental pathway of mtDNA homeostasis; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans; rare mutations in human mitochondrial elongation factor Tu (EFTu) associated with severe lactic acidosis, rapidly progressive fatal encephalopathy, severe infantile macrocystic leukodystrophy with micropolygyria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005713","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR187W"}


id: YOR188W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05004":null,"YOR188W":null},"has_protein_features":false,"name":"MSB1","ortholog_annotations":[{"gene_uniquename":"YOR188W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05004","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005714","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR188W"}


id: YOR189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00746":null,"YOR189W":null},"has_protein_features":false,"name":"IES4","ortholog_annotations":[{"gene_uniquename":"YOR189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00746","reference_uniquename":"PMID:29761456"}],"product":"Component of the INO80 chromatiin remodeling complex; target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005715","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR189W"}


id: YOR190W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01171":null,"SJAG_01888":null,"SJAG_05001":null,"YOR190W":null},"has_protein_features":false,"name":"SPR1","ortholog_annotations":[{"gene_uniquename":"YOR190W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01171","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR190W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01888","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR190W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05001","reference_uniquename":"PMID:29761456"}],"product":"Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance; SPR1 has a paralog, EXG1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005716","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR190W"}


id: YOR191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00475":null,"SJAG_02575":null,"YOR191W":null},"has_protein_features":false,"name":"ULS1","ortholog_annotations":[{"gene_uniquename":"YOR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00475","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02575","reference_uniquename":"PMID:29761456"}],"product":"Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL); required for maintenance of NHEJ inhibition at telomeres; functions at telomeres to translocate and ubiquitinylate poly-sumoylated Rap1p for proteosomal degradation; plays role in antagonizing silencing during mating-type switching; only known STUbL with a translocase activity; contains RING finger domain; relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005717","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR191W"}


id: YOR192C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"THI72","product":"Transporter of thiamine or related compound; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); shares sequence similarity with Thi7p","secondary_identifier":"SGD:S000005718","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR192C"}


id: YOR192C-C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028857","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR192C-C"}


id: YOR193W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PEX27","product":"Peripheral peroxisomal membrane protein; involved in controlling peroxisome size and number, interacts with Pex25p; PEX27 has a paralog, PEX25, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005719","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR193W"}


id: YOR194C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01710":null,"YOR194C":null},"has_protein_features":false,"name":"TOA1","ortholog_annotations":[{"gene_uniquename":"YOR194C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01710","reference_uniquename":"PMID:29761456"}],"product":"TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa2p, for ribosomal protein gene transcription in vivo; homologous to largest and second largest subunits of human and Drosophila TFIIA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005720","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR194C"}


id: YOR195W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02761":null,"YOR195W":null},"has_protein_features":false,"name":"SLK19","ortholog_annotations":[{"gene_uniquename":"YOR195W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02761","reference_uniquename":"PMID:29761456"}],"product":"Kinetochore-associated protein; required for chromosome segregation and kinetochore clustering; required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005721","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR195W"}


id: YOR196C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03553":null,"YOR196C":null},"has_protein_features":false,"name":"LIP5","ortholog_annotations":[{"gene_uniquename":"YOR196C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03553","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in biosynthesis of the coenzyme lipoic acid; has similarity to E. coli lipoic acid synthase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005722","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR196C"}


id: YOR197W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00135":null,"YOR197W":null},"has_protein_features":false,"name":"MCA1","ortholog_annotations":[{"gene_uniquename":"YOR197W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00135","reference_uniquename":"PMID:29761456"}],"product":"Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics and lifespan extension; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that block potential dimerization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005723","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR197W"}


id: YOR198C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00324":null,"YOR198C":null},"has_protein_features":false,"name":"BFR1","ortholog_annotations":[{"gene_uniquename":"YOR198C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00324","reference_uniquename":"PMID:29761456"}],"product":"Component of mRNP complexes associated with polyribosomes; involved in localization of mRNAs to P bodies; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR198C"}


id: YOR199W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005725","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR199W"}


id: YOR200W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c","secondary_identifier":"SGD:S000005726","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR200W"}


id: YOR201C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MRM1","product":"Ribose methyltransferase; modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA","secondary_identifier":"SGD:S000005727","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR201C"}


id: YOR202W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00592":null,"YOR202W":null},"has_protein_features":false,"name":"HIS3","ortholog_annotations":[{"gene_uniquename":"YOR202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00592","reference_uniquename":"PMID:29761456"}],"product":"Imidazoleglycerol-phosphate dehydratase; catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005728","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR202W"}


id: YOR203W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation","secondary_identifier":"SGD:S000005729","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR203W"}


id: YOR204W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00786":null,"YOR204W":null},"has_protein_features":false,"name":"DED1","ortholog_annotations":[{"gene_uniquename":"YOR204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00786","reference_uniquename":"PMID:29761456"}],"product":"ATP-dependent DEAD-box RNA helicase with strand-annealing activity; promotes eIF4F-dependent 48S translation preinitiation complex (PIC) assembly, stimulating recruitment of mRNAs with long, structured 5'-UTRs; cooperates with Dbp1p in PIC attachment and scanning; ATPase activity stimulated by mRNA cap-associated factor binding; directly binds eIF4G; role in spliceosomal complex disassembly; mutation in human homolog DBY associated with male infertility; human homolog DDX3X complements the null","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005730","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR204W"}


id: YOR205C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"GEP3","product":"Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (Phb1p)","secondary_identifier":"SGD:S000005731","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR205C"}


id: YOR206W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01494":null,"SJAG_04346":null,"YOR206W":null},"has_protein_features":false,"name":"NOC2","ortholog_annotations":[{"gene_uniquename":"YOR206W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01494","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR206W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04346","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in ribosome biogenesis; forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes; forms a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005732","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR206W"}


id: YOR207C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00637":null,"YOR207C":null},"has_protein_features":false,"name":"RET1","ortholog_annotations":[{"gene_uniquename":"YOR207C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00637","reference_uniquename":"PMID:29761456"}],"product":"Second-largest subunit of RNA polymerase III; RNA polymerase III is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005733","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR207C"}


id: YOR208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02000":null,"SJAG_02013":null,"YOR208W":null},"has_protein_features":false,"name":"PTP2","ortholog_annotations":[{"gene_uniquename":"YOR208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02000","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02013","reference_uniquename":"PMID:29761456"}],"product":"Phosphotyrosine-specific phosphatase; major role in osmolarity sensing through dephosphorylation of the Hog1p MAPK with a minor role by Ptp3p; inactivates and regulates Hog1p localization; major role in the cell wall integrity pathway through dephosphorylation of MAPK Slt2p with a minor role by Ptp3p; minor role with Msg5p in the pheromone adaptive response through dephosphorylation of MAPK Fus3p with major role by Ptp3p; co-regulates the calcium signaling pathway with Msg5p; nuclear localized","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005734","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR208W"}


id: YOR209C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03298":null,"YOR209C":null},"has_protein_features":false,"name":"NPT1","ortholog_annotations":[{"gene_uniquename":"YOR209C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03298","reference_uniquename":"PMID:29761456"}],"product":"Nicotinate phosphoribosyltransferase; acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005735","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR209C"}


id: YOR210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01765":null,"YOR210W":null},"has_protein_features":false,"name":"RPB10","ortholog_annotations":[{"gene_uniquename":"YOR210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01765","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase subunit ABC10-beta; common to RNA polymerases I, II, and III","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005736","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR210W"}


id: YOR211C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02656":null,"YOR211C":null},"has_protein_features":false,"name":"MGM1","ortholog_annotations":[{"gene_uniquename":"YOR211C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02656","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mitochondrial morphology, fusion, and genome maintenance; promotes membrane bending; plays a direct role in formation and maintenance of lamellar, but not of tubular, cristae; exists as long and short form with different distributions; ratio of long to short forms is regulated by Psd1p; homolog of human OPA1 involved in autosomal dominant optic atrophy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005737","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR211C"}


id: YOR212W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03081":null,"YOR212W":null},"has_protein_features":false,"name":"STE4","ortholog_annotations":[{"gene_uniquename":"YOR212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03081","reference_uniquename":"PMID:29761456"}],"product":"G protein beta subunit; forms a dimer with Ste18p to activate mating signaling pathway, forms heterotrimer with Gpa1p and Ste18p to dampen signaling; pheromone-induced phosphorylation plays critical role in chemotropism; may recruit Rho1p to polarized growth site during mating; contains WD40 repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005738","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR212W"}


id: YOR213C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00735":null,"YOR213C":null},"has_protein_features":false,"name":"SAS5","ortholog_annotations":[{"gene_uniquename":"YOR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00735","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the SAS complex (Sas2p, Sas4p, Sas5p); acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000005739","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR213C"}


id: YOR214C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPR2","product":"Putative spore wall protein; expression increases during sporulation; not an essential gene; YOR214C has a paralog, SPO19, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005740","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR214C"}


id: YOR215C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"AIM41","product":"Protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss","secondary_identifier":"SGD:S000005741","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR215C"}


id: YOR216C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04528":null,"YOR216C":null},"has_protein_features":false,"name":"RUD3","ortholog_annotations":[{"gene_uniquename":"YOR216C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04528","reference_uniquename":"PMID:29761456"}],"product":"Golgi matrix protein; involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005742","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR216C"}


id: YOR217W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00863":null,"YOR217W":null},"has_protein_features":false,"name":"RFC1","ortholog_annotations":[{"gene_uniquename":"YOR217W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00863","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005743","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR217W"}


id: YOR218C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W","secondary_identifier":"SGD:S000005744","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR218C"}


id: YOR219C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02565":null,"YOR219C":null},"has_protein_features":false,"name":"STE13","ortholog_annotations":[{"gene_uniquename":"YOR219C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02565","reference_uniquename":"PMID:29761456"}],"product":"Dipeptidyl aminopeptidase; Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005745","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR219C"}


id: YOR220W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RCN2","product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000005746","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR220W"}


id: YOR221C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03972":null,"YOR221C":null},"has_protein_features":false,"name":"MCT1","ortholog_annotations":[{"gene_uniquename":"YOR221C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03972","reference_uniquename":"PMID:29761456"}],"product":"Predicted malonyl-CoA:ACP transferase; putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005747","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR221C"}


id: YOR222W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00522":null,"YOR222W":null},"has_protein_features":false,"name":"ODC2","ortholog_annotations":[{"gene_uniquename":"YOR222W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00522","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism; ODC2 has a paralog, ODC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005748","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR222W"}


id: YOR223W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02703":null,"YOR223W":null},"has_protein_features":false,"name":"DSC3","ortholog_annotations":[{"gene_uniquename":"YOR223W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02703","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005749","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR223W"}


id: YOR224C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02070":null,"YOR224C":null},"has_protein_features":false,"name":"RPB8","ortholog_annotations":[{"gene_uniquename":"YOR224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02070","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase subunit ABC14.5; common to RNA polymerases I, II, and III","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005750","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR224C"}


id: YOR225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005751","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR225W"}


id: YOR226C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00532":null,"YOR226C":null},"has_protein_features":false,"name":"ISU2","ortholog_annotations":[{"gene_uniquename":"YOR226C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00532","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for iron-sulfur protein synthesis; performs scaffolding function during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; protein abundance increases under DNA replication stress; ISU2 has a paralog, ISU1, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005752","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR226C"}


id: YOR227W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HER1","product":"Protein of unknown function; required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005753","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR227W"}


id: YOR228C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MCP1","product":"Mitochondrial protein of unknown function involved in lipid homeostasis; integral membrane protein that localizes to the mitochondrial outer membrane; involved in mitochondrial morphology; interacts genetically with MDM10, and other members of the ERMES complex; contains five predicted transmembrane domains","secondary_identifier":"SGD:S000005754","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR228C"}


id: YOR229W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04758":null,"YOR229W":null},"has_protein_features":false,"name":"WTM2","ortholog_annotations":[{"gene_uniquename":"YOR229W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04758","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats; relocalizes to the cytosol in response to hypoxia; WTM2 has a paralog, UME1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005755","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR229W"}


id: YOR230W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04758":null,"YOR230W":null},"has_protein_features":false,"name":"WTM1","ortholog_annotations":[{"gene_uniquename":"YOR230W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04758","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; acts as a nuclear anchor to retain the ribonucleotide reductase small subunit heterodimer, Rnr2p-Rnr4p, in the nucleus when cells are not in S phase; contains WD repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005756","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR230W"}


id: YOR231C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028716","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR231C-A"}


id: YOR231W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01181":null,"YOR231W":null},"has_protein_features":false,"name":"MKK1","ortholog_annotations":[{"gene_uniquename":"YOR231W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01181","reference_uniquename":"PMID:29761456"}],"product":"MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005757","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR231W"}


id: YOR232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04014":null,"YOR232W":null},"has_protein_features":false,"name":"MGE1","ortholog_annotations":[{"gene_uniquename":"YOR232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04014","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial matrix cochaperone; nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; acts as oxidative sensor to regulate mitochondrial Ssc1p; in presence of oxidative stress, dimeric Mge1p becomes a monomer and unable to regulate Ssc1p function; homolog of E. coli GrpE and human Mge1 (GRPEL1), which also responds to oxidative stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005758","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR232W"}


id: YOR233W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04507":null,"YOR233W":null},"has_protein_features":false,"name":"KIN4","ortholog_annotations":[{"gene_uniquename":"YOR233W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04507","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005759","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR233W"}


id: YOR234C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00166":null,"SJAG_04414":null,"YOR234C":null},"has_protein_features":false,"name":"RPL33B","ortholog_annotations":[{"gene_uniquename":"YOR234C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00166","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR234C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04414","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005760","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR234C"}


id: YOR235W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"IRC13","product":"Putative protein of unknown function; conserved across S. cerevisiae strains; null mutant displays increased levels of spontaneous Rad52 foci","secondary_identifier":"SGD:S000005761","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR235W"}


id: YOR236W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01198":null,"YOR236W":null},"has_protein_features":false,"name":"DFR1","ortholog_annotations":[{"gene_uniquename":"YOR236W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01198","reference_uniquename":"PMID:29761456"}],"product":"Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism; mutation is functionally complemented by human DHFR","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005762","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR236W"}


id: YOR237W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01590":null,"SJAG_02323":null,"SJAG_02375":null,"SJAG_03718":null,"YOR237W":null},"has_protein_features":false,"name":"HES1","ortholog_annotations":[{"gene_uniquename":"YOR237W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01590","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR237W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02323","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR237W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02375","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR237W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03718","reference_uniquename":"PMID:29761456"}],"product":"Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); SWAT-GFP and mCherry fusion proteins localize to the bud neck and vacuolar membrane; HES1 has a paralog, KES1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005763","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR237W"}


id: YOR238W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00190":null,"YOR238W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR238W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00190","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005764","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR238W"}


id: YOR239W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00499":null,"SJAG_04453":null,"YOR239W":null},"has_protein_features":false,"name":"ABP140","ortholog_annotations":[{"gene_uniquename":"YOR239W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00499","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR239W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04453","reference_uniquename":"PMID:29761456"}],"product":"AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005765","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR239W"}


id: YOR240W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YOR240W was originally annotated as an independent ORF, but was later demonstrated to be part of an adjacent ORF, YOR239W, via a +1 translational frameshift","secondary_identifier":"SGD:S000005766","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR240W"}


id: YOR241W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03224":null,"YOR241W":null},"has_protein_features":false,"name":"MET7","ortholog_annotations":[{"gene_uniquename":"YOR241W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03224","reference_uniquename":"PMID:29761456"}],"product":"Folylpolyglutamate synthetase; catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005767","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR241W"}


id: YOR242C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SSP2","product":"Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; expression controlled by a tightly regulated middle-meiotic promoter that is activated by Ndt80p; translation of SSP2 mRNA is delayed, such that the mRNA is present as nuclear divisions are taking place but is not engaged by ribosomes until relatively late in meiotic development","secondary_identifier":"SGD:S000005768","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR242C"}


id: YOR243C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03572":null,"YOR243C":null},"has_protein_features":false,"name":"PUS7","ortholog_annotations":[{"gene_uniquename":"YOR243C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03572","reference_uniquename":"PMID:29761456"}],"product":"Pseudouridine synthase; catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); also pseudouridylates some mRNAs; relocates from nucleus to cytoplasm during heat shock and differentially modifies some mRNAs during heat shock; conserved in archaea, vertebrates, and some bacteria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005769","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR243C"}


id: YOR244W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02990":null,"YOR244W":null},"has_protein_features":false,"name":"ESA1","ortholog_annotations":[{"gene_uniquename":"YOR244W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02990","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; master regulator of cellular acetylation balance; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; human ortholog TIP60/KAT5 is implicated in cancer and other diseases, functionally complements lethality of the esa1 null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005770","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR244W"}


id: YOR245C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03609":null,"YOR245C":null},"has_protein_features":false,"name":"DGA1","ortholog_annotations":[{"gene_uniquename":"YOR245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03609","reference_uniquename":"PMID:29761456"}],"product":"Diacylglycerol acyltransferase; catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor; Lro1p and Dga1p can O-acylate ceramides; localized to lipid particles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005771","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR245C"}


id: YOR246C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02623":null,"YOR246C":null},"has_protein_features":false,"name":"ENV9","ortholog_annotations":[{"gene_uniquename":"YOR246C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02623","reference_uniquename":"PMID:29761456"}],"product":"Conserved oxidoreductase involved in lipid droplet morphology; mutant shows defects in CPY processing and vacuolar morphology; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts; homologus to human RDH12 linked to Leber Congenital Amaurosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005772","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR246C"}


id: YOR247W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SRL1","product":"Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005773","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR247W"}


id: YOR248W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005774","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR248W"}


id: YOR249C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04661":null,"YOR249C":null},"has_protein_features":false,"name":"APC5","ortholog_annotations":[{"gene_uniquename":"YOR249C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04661","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005775","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR249C"}


id: YOR250C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01791":null,"YOR250C":null},"has_protein_features":false,"name":"CLP1","ortholog_annotations":[{"gene_uniquename":"YOR250C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01791","reference_uniquename":"PMID:29761456"}],"product":"Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation and in gene looping which affects reinitiation of transcription; mutations in human ortholog cause cerebellar neurodegeneration","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005776","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR250C"}


id: YOR251C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04113":null,"YOR251C":null},"has_protein_features":false,"name":"TUM1","ortholog_annotations":[{"gene_uniquename":"YOR251C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04113","reference_uniquename":"PMID:29761456"}],"product":"Rhodanese domain sulfur transferase; accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; involved in metabolism of sterol esters; may be mitochondrially localized","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005777","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR251C"}


id: YOR252W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TMA16","product":"Protein of unknown function that associates with ribosomes","secondary_identifier":"SGD:S000005778","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR252W"}


id: YOR253W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02726":null,"YOR253W":null},"has_protein_features":false,"name":"NAT5","ortholog_annotations":[{"gene_uniquename":"YOR253W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02726","reference_uniquename":"PMID:29761456"}],"product":"Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005779","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR253W"}


id: YOR254C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00175":null,"YOR254C":null},"has_protein_features":false,"name":"SEC63","ortholog_annotations":[{"gene_uniquename":"YOR254C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00175","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; other members are Sec62p, Sec66p, and Sec72p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005780","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR254C"}


id: YOR255W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"OSW1","product":"Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p","secondary_identifier":"SGD:S000005781","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR255W"}


id: YOR256C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02117":null,"YOR256C":null},"has_protein_features":false,"name":"TRE2","ortholog_annotations":[{"gene_uniquename":"YOR256C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02117","reference_uniquename":"PMID:29761456"}],"product":"Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitination and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005782","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR256C"}


id: YOR257W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01760":null,"YOR257W":null},"has_protein_features":false,"name":"CDC31","ortholog_annotations":[{"gene_uniquename":"YOR257W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01760","reference_uniquename":"PMID:29761456"}],"product":"Calcium-binding component of the spindle pole body (SPB) half-bridge; required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005783","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR257W"}


id: YOR258W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04410":null,"YOR258W":null},"has_protein_features":false,"name":"HNT3","ortholog_annotations":[{"gene_uniquename":"YOR258W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04410","reference_uniquename":"PMID:29761456"}],"product":"DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR258W"}


id: YOR259C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00766":null,"YOR259C":null},"has_protein_features":false,"name":"RPT4","ortholog_annotations":[{"gene_uniquename":"YOR259C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00766","reference_uniquename":"PMID:29761456"}],"product":"ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005785","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR259C"}


id: YOR260W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01659":null,"YOR260W":null},"has_protein_features":false,"name":"GCD1","ortholog_annotations":[{"gene_uniquename":"YOR260W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01659","reference_uniquename":"PMID:29761456"}],"product":"Gamma subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005786","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR260W"}


id: YOR261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00762":null,"YOR261C":null},"has_protein_features":false,"name":"RPN8","ortholog_annotations":[{"gene_uniquename":"YOR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00762","reference_uniquename":"PMID:29761456"}],"product":"Essential non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005787","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR261C"}


id: YOR262W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00065":null,"YOR262W":null},"has_protein_features":false,"name":"GPN2","ortholog_annotations":[{"gene_uniquename":"YOR262W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00065","reference_uniquename":"PMID:29761456"}],"product":"Putative GTPase with a specific role in RNA pol II and polIII biogenesis; involved in the assembly and subsequent nuclear import of RNA polymerases II and III; required for establishment of sister chromatid cohesion; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005788","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR262W"}


id: YOR263C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W","secondary_identifier":"SGD:S000005789","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR263C"}


id: YOR264W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"DSE3","product":"Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress; interacts with Csm1p","secondary_identifier":"SGD:S000005790","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR264W"}


id: YOR265W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02270":null,"YOR265W":null},"has_protein_features":false,"name":"RBL2","ortholog_annotations":[{"gene_uniquename":"YOR265W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02270","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005791","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR265W"}


id: YOR266W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"PNT1","product":"Mitochondrial integral inner membrane protein; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine","secondary_identifier":"SGD:S000005792","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR266W"}


id: YOR267C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00963":null,"SJAG_04268":null,"YOR267C":null},"has_protein_features":false,"name":"HRK1","ortholog_annotations":[{"gene_uniquename":"YOR267C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00963","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR267C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04268","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005793","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR267C"}


id: YOR268C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; sporulation is abnormal in homozygous diploid; SWAT-GFP fusion protein localizes to the nucleus; YOR268C is not an essential gene","secondary_identifier":"SGD:S000005794","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR268C"}


id: YOR269W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00511":null,"YOR269W":null},"has_protein_features":false,"name":"PAC1","ortholog_annotations":[{"gene_uniquename":"YOR269W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00511","reference_uniquename":"PMID:26896847"}],"product":"Regulator of dynein, involved in intracellular transport; part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000005795","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR269W"}


id: YOR270C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00516":null,"YOR270C":null},"has_protein_features":false,"name":"VPH1","ortholog_annotations":[{"gene_uniquename":"YOR270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00516","reference_uniquename":"PMID:29761456"}],"product":"Subunit a of the vacuolar-ATPase V0 domain; encodes one of two isoforms, located in vacuolar V-ATPase complexes while STV1 encodes the second isoform and is located in Golgi and endosomal V-ATPase complexes; interaction with PI(3,5)P2 increases V-ATPase activity and contributes to hyperosmotic stress tolerance; relative distribution to the vacuolar membrane decreases upon DNA replication stress; human homolog ATP6V0A4 implicated in renal tubular acidosis, can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005796","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR270C"}


id: YOR271C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04588":null,"YOR271C":null},"has_protein_features":false,"name":"FSF1","ortholog_annotations":[{"gene_uniquename":"YOR271C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04588","reference_uniquename":"PMID:29761456"}],"product":"Putative protein; predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005797","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR271C"}


id: YOR272W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02759":null,"YOR272W":null},"has_protein_features":false,"name":"YTM1","ortholog_annotations":[{"gene_uniquename":"YOR272W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02759","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal assembly factor and 66S pre-ribosomal particle constituent; subunit of the Nop7-subcomplex (PeBoW complex), required for an early nucleolar step in pre-60S ribosomal particle maturation; interaction of its ubiquitin-like (UBL) domain with the MIDAS domain in the Rea1p tail triggers release of the subcomplex and possibly other biogenesis factors via cycles of ATP hydrolysis; involved in the processing of 27S pre-rRNA; contains an N-terminal UBL domain and seven C-terminal WD repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005798","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR272W"}


id: YOR273C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"TPO4","product":"Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane","secondary_identifier":"SGD:S000005799","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR273C"}


id: YOR274W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01575":null,"YOR274W":null},"has_protein_features":false,"name":"MOD5","ortholog_annotations":[{"gene_uniquename":"YOR274W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01575","reference_uniquename":"PMID:29761456"}],"product":"Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; also has a role in tRNA gene-mediated silencing; gene encodes two isozymic forms; converts to a prion form, prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis; homolog of human TRIT1, a mutation in which is associated with severe combined respiratory chain defects","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005800","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR274W"}


id: YOR275C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02584":null,"SJAG_03891":null,"YOR275C":null},"has_protein_features":false,"name":"RIM20","ortholog_annotations":[{"gene_uniquename":"YOR275C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02584","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOR275C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03891","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005801","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR275C"}


id: YOR276W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"CAF20","product":"Phosphoprotein of the mRNA cap-binding complex; involved in translational control; repressor of cap-dependent translational initiation; translational activator of select mRNAs during filamentous growth; competes with eIF4G for binding to eIF4E","secondary_identifier":"SGD:S000005802","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR276W"}


id: YOR277C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20","secondary_identifier":"SGD:S000005803","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR277C"}


id: YOR278W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05283":null,"YOR278W":null},"has_protein_features":false,"name":"HEM4","ortholog_annotations":[{"gene_uniquename":"YOR278W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05283","reference_uniquename":"PMID:29761456"}],"product":"Uroporphyrinogen III synthase; catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005804","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR278W"}


id: YOR279C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"RFM1","product":"Component of the Sum1p-Rfm1p-Hst1p complex; Rfm1p tethers the Hst1p histone deacetylase to the DNA-binding protein Sum1p; complex is involved in transcriptional repression of middle sporulation genes and in initiation of DNA replication","secondary_identifier":"SGD:S000005805","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR279C"}


id: YOR280C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01198":null,"SJAG_03760":null,"YOR280C":null},"has_protein_features":false,"name":"FSH3","ortholog_annotations":[{"gene_uniquename":"YOR280C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01198","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR280C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03760","reference_uniquename":"PMID:26896847"}],"product":"Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR280C"}


id: YOR281C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00558":null,"YOR281C":null},"has_protein_features":false,"name":"PLP2","ortholog_annotations":[{"gene_uniquename":"YOR281C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00558","reference_uniquename":"PMID:29761456"}],"product":"Protein that interacts with the CCT complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP; CCT is short for chaperonin containing TCP-1; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR281C"}


id: YOR282W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C","secondary_identifier":"SGD:S000005808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR282W"}


id: YOR283W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00685":null,"YOR283W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR283W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00685","reference_uniquename":"PMID:29761456"}],"product":"Phosphatase with a broad substrate specificity; has some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005809","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR283W"}


id: YOR284W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"HUA2","product":"Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly","secondary_identifier":"SGD:S000005810","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR284W"}


id: YOR285W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01239":null,"YOR285W":null},"has_protein_features":false,"name":"RDL1","ortholog_annotations":[{"gene_uniquename":"YOR285W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01239","reference_uniquename":"PMID:29761456"}],"product":"Thiosulfate sulfurtransferase; contains a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress; similar to the human TSTD gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR285W"}


id: YOR286W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01239":null,"YOR286W":null},"has_protein_features":false,"name":"RDL2","ortholog_annotations":[{"gene_uniquename":"YOR286W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01239","reference_uniquename":"PMID:29761456"}],"product":"Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR286W"}


id: YOR287C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04979":null,"YOR287C":null},"has_protein_features":false,"name":"RRP36","ortholog_annotations":[{"gene_uniquename":"YOR287C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04979","reference_uniquename":"PMID:29761456"}],"product":"Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005813","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR287C"}


id: YOR288C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04046":null,"YOR288C":null},"has_protein_features":false,"name":"MPD1","ortholog_annotations":[{"gene_uniquename":"YOR288C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04046","reference_uniquename":"PMID:29761456"}],"product":"Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005814","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR288C"}


id: YOR289W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05222":null,"YOR289W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR289W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05222","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005815","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR289W"}


id: YOR290C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04755":null,"SJAG_05313":null,"YOR290C":null},"has_protein_features":false,"name":"SNF2","ortholog_annotations":[{"gene_uniquename":"YOR290C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04755","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR290C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05313","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005816","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR290C"}


id: YOR291W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03866":null,"SJAG_04757":null,"YOR291W":null},"has_protein_features":false,"name":"YPK9","ortholog_annotations":[{"gene_uniquename":"YOR291W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03866","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR291W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04757","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar protein with a possible role in sequestering heavy metals; involved in the oxidative stress response and modulation of replicative lifespan; undergoes autophosphorylation, which is abolished by mutation of Asp781 in the catalytic motif (D781N); P5 ATPase subfamily member with similarity to yeast Spf1p and homology of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005817","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR291W"}


id: YOR292C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00631":null,"SJAG_01649":null,"YOR292C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR292C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00631","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOR292C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01649","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005818","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR292C"}


id: YOR293C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028858","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR293C-A"}


id: YOR293W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02904":null,"SJAG_04695":null,"YOR293W":null},"has_protein_features":false,"name":"RPS10A","ortholog_annotations":[{"gene_uniquename":"YOR293W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02904","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR293W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04695","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication; mutations in the human homolog associated with Diamond-Blackfan anemia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005819","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR293W"}


id: YOR294W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02644":null,"YOR294W":null},"has_protein_features":false,"name":"RRS1","ortholog_annotations":[{"gene_uniquename":"YOR294W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02644","reference_uniquename":"PMID:29761456"}],"product":"Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005820","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR294W"}


id: YOR295W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02747":null,"YOR295W":null},"has_protein_features":false,"name":"UAF30","ortholog_annotations":[{"gene_uniquename":"YOR295W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02747","reference_uniquename":"PMID:29761456"}],"product":"Subunit of UAF (upstream activation factor) complex; UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; targeting factor for the UAF that facilitates activation of many rDNA genes; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005821","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR295W"}


id: YOR296W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00472":null,"SJAG_02572":null,"YOR296W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR296W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00472","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOR296W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02572","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005822","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR296W"}


id: YOR297C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02398":null,"YOR297C":null},"has_protein_features":false,"name":"TIM18","ortholog_annotations":[{"gene_uniquename":"YOR297C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02398","reference_uniquename":"PMID:29761456"}],"product":"Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005823","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR297C"}


id: YOR298C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00269":null,"YOR298C-A":null},"has_protein_features":false,"name":"MBF1","ortholog_annotations":[{"gene_uniquename":"YOR298C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00269","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR298C-A"}


id: YOR298W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MUM3","product":"Protein of unknown function involved in outer spore wall organization; has similarity to the tafazzins superfamily of acyltransferases","secondary_identifier":"SGD:S000005824","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR298W"}


id: YOR299W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00916":null,"YOR299W":null},"has_protein_features":false,"name":"BUD7","ortholog_annotations":[{"gene_uniquename":"YOR299W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00916","reference_uniquename":"PMID:29761456"}],"product":"Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005825","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR299W"}


id: YOR300W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7","secondary_identifier":"SGD:S000005826","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR300W"}


id: YOR301W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00745":null,"YOR301W":null},"has_protein_features":false,"name":"RAX1","ortholog_annotations":[{"gene_uniquename":"YOR301W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00745","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in establishing bud site selection; localizes to the bud neck and previous sites of cell division (bud scars or cytokinesis remnants (CRMs); localization to both sites is interdependent with Rax2p; required with Rax2p to anchor Nba1p and Nis1p to CRMs where a Cdc42p inhibitory zone is established, preventing repolarization of cells at previous division sites; predicted type IIIa transmembrane protein with similarity to members of the insulin-related peptide superfamily","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005827","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR301W"}


id: YOR302W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"CPA1 uORF; Arginine attenuator peptide, regulates translation of the CPA1 mRNA","secondary_identifier":"SGD:S000005828","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR302W"}


id: YOR303W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00392":null,"YOR303W":null},"has_protein_features":false,"name":"CPA1","ortholog_annotations":[{"gene_uniquename":"YOR303W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00392","reference_uniquename":"PMID:29761456"}],"product":"Small subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005829","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR303W"}


id: YOR304C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"BIL1","product":"Protein that binds Bud6p and has a role in actin cable assembly; involved in the Bnr1p-dependent pathway of cable assembly; localizes to bud tip and bud neck","secondary_identifier":"SGD:S000005830","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR304C-A"}


id: YOR304W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"ISW2","product":"ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth; exhibits basal levels of chromatin binding throughout the genome as well as interacts with sequence-specific factors to accurately position nucleosomes in chromatin; targeted by Ume6p- and Sua7p-dependent DNA looping to many loci genome-wide","secondary_identifier":"SGD:S000005831","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR304W"}


id: YOR305W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01569":null,"YOR305W":null},"has_protein_features":false,"name":"RRG7","ortholog_annotations":[{"gene_uniquename":"YOR305W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01569","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005832","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR305W"}


id: YOR306C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"MCH5","product":"Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport","secondary_identifier":"SGD:S000005833","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR306C"}


id: YOR307C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00276":null,"YOR307C":null},"has_protein_features":false,"name":"SLY41","ortholog_annotations":[{"gene_uniquename":"YOR307C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00276","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in ER-to-Golgi transport; packaged into COPII vesicles for trafficking between ER and Golgi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005834","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR307C"}


id: YOR308C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04433":null,"YOR308C":null},"has_protein_features":false,"name":"SNU66","ortholog_annotations":[{"gene_uniquename":"YOR308C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04433","reference_uniquename":"PMID:29761456"}],"product":"Component of the U4/U6.U5 snRNP complex; involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005835","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR308C"}


id: YOR309C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58","secondary_identifier":"SGD:S000005836","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR309C"}


id: YOR310C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00744":null,"YOR310C":null},"has_protein_features":false,"name":"NOP58","ortholog_annotations":[{"gene_uniquename":"YOR310C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00744","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in producing mature rRNAs and snoRNAs; involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005837","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR310C"}


id: YOR311C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04883":null,"YOR311C":null},"has_protein_features":false,"name":"DGK1","ortholog_annotations":[{"gene_uniquename":"YOR311C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04883","reference_uniquename":"PMID:29761456"}],"product":"Diacylglycerol kinase; localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005838","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR311C"}


id: YOR312C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02283":null,"SJAG_04897":null,"YOR312C":null},"has_protein_features":false,"name":"RPL20B","ortholog_annotations":[{"gene_uniquename":"YOR312C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02283","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR312C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04897","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005839","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR312C"}


id: YOR313C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SPS4","product":"Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage","secondary_identifier":"SGD:S000005840","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR313C"}


id: YOR314W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000005841","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR314W"}


id: YOR314W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR314W-A"}


id: YOR315W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SFG1","product":"Nuclear protein putative transcription factor; required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate","secondary_identifier":"SGD:S000005842","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR315W"}


id: YOR316C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01078":null,"SJAG_01803":null,"YOR316C":null},"has_protein_features":false,"name":"COT1","ortholog_annotations":[{"gene_uniquename":"YOR316C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01078","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR316C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01803","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005843","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR316C"}


id: YOR316C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028584","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR316C-A"}


id: YOR317W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03471":null,"SJAG_03909":null,"YOR317W":null},"has_protein_features":false,"name":"FAA1","ortholog_annotations":[{"gene_uniquename":"YOR317W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03471","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR317W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03909","reference_uniquename":"PMID:29761456"}],"product":"Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatty acids and sphingoid long-chain bases; accounts for most acyl-CoA synthetase activity; localizes to lipid particles and the plasma membrane; role in sphingolipid-to-glycerolipid metabolism; forms ER foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6, SLC27A2, or 4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005844","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR317W"}


id: YOR318C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo","secondary_identifier":"SGD:S000005845","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR318C"}


id: YOR319W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00504":null,"YOR319W":null},"has_protein_features":false,"name":"HSH49","ortholog_annotations":[{"gene_uniquename":"YOR319W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00504","reference_uniquename":"PMID:29761456"}],"product":"U2-snRNP associated splicing factor; similar to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005846","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR319W"}


id: YOR320C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03149":null,"SJAG_03150":null,"YOR320C":null},"has_protein_features":false,"name":"GNT1","ortholog_annotations":[{"gene_uniquename":"YOR320C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR320C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03150","reference_uniquename":"PMID:29761456"}],"product":"N-acetylglucosaminyltransferase; capable of modification of N-linked glycans in the Golgi apparatus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005847","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR320C"}


id: YOR321W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04053":null,"YOR321W":null},"has_protein_features":false,"name":"PMT3","ortholog_annotations":[{"gene_uniquename":"YOR321W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04053","reference_uniquename":"PMID:29761456"}],"product":"Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005848","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR321W"}


id: YOR322C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02789":null,"SJAG_03404":null,"YOR322C":null},"has_protein_features":false,"name":"LDB19","ortholog_annotations":[{"gene_uniquename":"YOR322C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02789","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR322C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03404","reference_uniquename":"PMID:29761456"}],"product":"Alpha-arrestin, Ub-ligase adaptor for Rsp5p; regulates starvation- and substrate-induced Ub-dependent endocytosis of select plasma membrane localized amino acid transporters, recruiting Rsp5p to its targets; role in basal internalization and turnover of Ste2p, mating and zygote formation; recruits Rsp5p to Ste2p via its 2 PPXY motifs; inhibited by Npr1p-mediated phosphorylation, affecting cytosol and plasma membrane translocation; localization regulated by Rsp5p-dependent ubiquitination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005849","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR322C"}


id: YOR323C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00660":null,"YOR323C":null},"has_protein_features":false,"name":"PRO2","ortholog_annotations":[{"gene_uniquename":"YOR323C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00660","reference_uniquename":"PMID:29761456"}],"product":"Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005850","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR323C"}


id: YOR324C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"FRT1","product":"Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005851","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR324C"}


id: YOR325W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1","secondary_identifier":"SGD:S000005852","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR325W"}


id: YOR326W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00938":null,"SJAG_03011":null,"YOR326W":null},"has_protein_features":false,"name":"MYO2","ortholog_annotations":[{"gene_uniquename":"YOR326W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00938","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR326W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03011","reference_uniquename":"PMID:29761456"}],"product":"Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, lipid droplets, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005853","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR326W"}


id: YOR327C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02241":null,"YOR327C":null},"has_protein_features":false,"name":"SNC2","ortholog_annotations":[{"gene_uniquename":"YOR327C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02241","reference_uniquename":"PMID:29761456"}],"product":"Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; Snc2p levels regulated by Vps45p; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005854","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR327C"}


id: YOR328W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04277":null,"YOR328W":null},"has_protein_features":false,"name":"PDR10","ortholog_annotations":[{"gene_uniquename":"YOR328W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"ATP-binding cassette (ABC) transporter; multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005855","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR328W"}


id: YOR329C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"name":"SCD5","product":"Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency","secondary_identifier":"SGD:S000005856","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR329C"}


id: YOR329W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028585","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR329W-A"}


id: YOR330C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_02658":null,"YOR330C":null},"has_protein_features":false,"name":"MIP1","ortholog_annotations":[{"gene_uniquename":"YOR330C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02658","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial DNA polymerase gamma; single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoan complex of catalytic and accessory subunits; polymorphic in yeast, petites occur more frequently in some lab strains; human ortholog POLG complements yeast mip1 mutant; mutations in human POLG associated with Alpers-Huttenlocher syndrome (AHS), progressive external ophthalmoplegia (PEO), parkinsonism, other mitochondrial diseases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005857","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR330C"}


id: YOR331C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W","secondary_identifier":"SGD:S000005858","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR331C"}


id: YOR332W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_00212":null,"YOR332W":null},"has_protein_features":false,"name":"VMA4","ortholog_annotations":[{"gene_uniquename":"YOR332W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00212","reference_uniquename":"PMID:29761456"}],"product":"Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005859","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR332W"}


id: YOR333C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of MRS2 gene required for respiratory growth","secondary_identifier":"SGD:S000005860","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR333C"}


id: YOR334W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01639":null,"YOR334W":null},"has_protein_features":false,"name":"MRS2","ortholog_annotations":[{"gene_uniquename":"YOR334W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01639","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; similar to bacterial CorA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005861","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR334W"}


id: YOR335C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01797":null,"YOR335C":null},"has_protein_features":false,"name":"ALA1","ortholog_annotations":[{"gene_uniquename":"YOR335C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01797","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic and mitochondrial alanyl-tRNA synthetase; required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog AARS; mutations in human homolog AARS are associated with autoimmune disease polymyositis/dermatomyositis and with hereditary peripheral neuropathy, Charcot-Marie-Tooth (CMT) disease","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005862","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR335C"}


id: YOR335W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ALA1/YOR335C","secondary_identifier":"SGD:S000028717","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR335W-A"}


id: YOR336W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_04571":null,"YOR336W":null},"has_protein_features":false,"name":"KRE5","ortholog_annotations":[{"gene_uniquename":"YOR336W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04571","reference_uniquename":"PMID:29761456"}],"product":"Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005863","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR336W"}


id: YOR337W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_05337":null,"YOR337W":null},"has_protein_features":false,"name":"TEA1","ortholog_annotations":[{"gene_uniquename":"YOR337W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05337","reference_uniquename":"PMID:29761456"}],"product":"Ty1 enhancer activator involved in Ty enhancer-mediated transcription; required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005864","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR337W"}


id: YOR338W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_03441":null,"YOR338W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR338W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03441","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005865","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR338W"}


id: YOR339C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","genes_by_uniquename":{"SJAG_01679":null,"YOR339C":null},"has_protein_features":false,"name":"UBC11","ortholog_annotations":[{"gene_uniquename":"YOR339C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01679","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-conjugating enzyme; most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005866","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR339C"}


