# genes

id: YHR172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03835":null,"YHR172W":null},"has_protein_features":false,"name":"SPC97","ortholog_annotations":[{"gene_uniquename":"YHR172W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03835","reference_uniquename":"PMID:29761456"}],"product":"Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001215","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR172W"}


id: YHR173C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels; SWAT-GFP and mCherry fusion proteins localize to the vacuole","secondary_identifier":"SGD:S000001216","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR173C"}


id: YHR174W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00461":null,"SJAG_02107":null,"SJAG_02369":null,"YHR174W":null},"has_protein_features":false,"name":"ENO2","ortholog_annotations":[{"gene_uniquename":"YHR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00461","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02107","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02369","reference_uniquename":"PMID:29761456"}],"product":"Enolase II, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression induced in response to glucose; ENO2 has a paralog, ENO1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001217","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR174W"}


id: YHR175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CTR2","product":"Low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation; regulated by nonsense-mediated mRNA decay pathway","secondary_identifier":"SGD:S000001218","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR175W"}


id: YHR175W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028553","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR175W-A"}


id: YHR176W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04608":null,"YHR176W":null},"has_protein_features":false,"name":"FMO1","ortholog_annotations":[{"gene_uniquename":"YHR176W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04608","reference_uniquename":"PMID:29761456"}],"product":"Flavin-containing monooxygenase; localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001219","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR176W"}


id: YHR177W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02921":null,"SJAG_04920":null,"YHR177W":null},"has_protein_features":false,"name":"ROF1","ortholog_annotations":[{"gene_uniquename":"YHR177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02921","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04920","reference_uniquename":"PMID:29761456"}],"product":"Putative transcription factor containing a WOPR domain; binds DNA in vitro; similar to C. albicans Wor1p transcription factor that regulates white-opaque switching; overexpression causes a cell cycle delay or arrest","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001220","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR177W"}


id: YHR178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STB5","product":"Transcription factor; involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro","secondary_identifier":"SGD:S000001221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR178W"}


id: YHR179W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OYE2","product":"Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000001222","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR179W"}


id: YHR180C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YHR180W-A","secondary_identifier":"SGD:S000028554","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR180C-B"}


id: YHR180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000001223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR180W"}


id: YHR180W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3","secondary_identifier":"SGD:S000028555","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR180W-A"}


id: YHR181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00785":null,"YHR181W":null},"has_protein_features":false,"name":"SVP26","ortholog_annotations":[{"gene_uniquename":"YHR181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00785","reference_uniquename":"PMID:29761456"}],"product":"ER exit adaptor for Golgi mannosyltransferases; facilitates the exit of Kre2p, Ktr1p and Mnn4p from the ER; involved in COPII-coated vesicle cargo loading and transport; may also promote the retention of proteins in the early Golgi compartment; integral membrane protein of early Golgi and ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR181W"}


id: YHR182C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF GND1/YHR183W","secondary_identifier":"SGD:S000028784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR182C-A"}


id: YHR182W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RGD3","product":"GTPase activating protein (GAP) for Rho3p, involved in cell polarity green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000001225","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR182W"}


id: YHR183W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03852":null,"YHR183W":null},"has_protein_features":false,"name":"GND1","ortholog_annotations":[{"gene_uniquename":"YHR183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03852","reference_uniquename":"PMID:29761456"}],"product":"6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001226","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR183W"}


id: YHR184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SSP1","product":"Protein involved in the control of meiotic nuclear division; involved in the coordination of meiosis with spore formation; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; required for assembly of the leading edge coat and both prospore membrane shaping and organization; transcription is induced midway through meiosis","secondary_identifier":"SGD:S000001227","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR184W"}


id: YHR185C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PFS1","product":"Sporulation protein required for prospore membrane formation; required for prospore membrane formation at selected spindle poles; ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation","secondary_identifier":"SGD:S000001228","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR185C"}


id: YHR186C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01509":null,"YHR186C":null},"has_protein_features":false,"name":"KOG1","ortholog_annotations":[{"gene_uniquename":"YHR186C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01509","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TORC1; TORC1 is a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001229","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR186C"}


id: YHR187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04175":null,"YHR187W":null},"has_protein_features":false,"name":"IKI1","ortholog_annotations":[{"gene_uniquename":"YHR187W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04175","reference_uniquename":"PMID:29761456"}],"product":"Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR187W"}


id: YHR188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00846":null,"YHR188C":null},"has_protein_features":false,"name":"GPI16","ortholog_annotations":[{"gene_uniquename":"YHR188C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00846","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the glycosylphosphatidylinositol transamidase complex; involved in the addition of GPIs to newly synthesized proteins; luminally-oriented, type I integral membrane glycoprotein of the ER; human PIG-T homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR188C"}


id: YHR189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00936":null,"YHR189W":null},"has_protein_features":false,"name":"PTH1","ortholog_annotations":[{"gene_uniquename":"YHR189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00936","reference_uniquename":"PMID:29761456"}],"product":"One of two mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium; see also PTH2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR189W"}


id: YHR190W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02719":null,"YHR190W":null},"has_protein_features":false,"name":"ERG9","ortholog_annotations":[{"gene_uniquename":"YHR190W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02719","reference_uniquename":"PMID:29761456"}],"product":"Farnesyl-diphosphate farnesyl transferase (squalene synthase); joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR190W"}


id: YHR191C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02373":null,"YHR191C":null},"has_protein_features":false,"name":"CTF8","ortholog_annotations":[{"gene_uniquename":"YHR191C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02373","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a complex with Ctf18p; shares some subunits with Replication Factor C; required for sister chromatid cohesion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR191C"}


id: YHR192W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03812":null,"YHR192W":null},"has_protein_features":false,"name":"LNP1","ortholog_annotations":[{"gene_uniquename":"YHR192W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03812","reference_uniquename":"PMID:29761456"}],"product":"Lunapark family member involved in ER network formation; regulates the ER asymmetry-induced inheritance block during ER stress; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; required for reticulophagy where it is proposed to stabilize the actin-dependent remodeling of the ER; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR192W"}


id: YHR193C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01641":null,"YHR193C":null},"has_protein_features":false,"name":"EGD2","ortholog_annotations":[{"gene_uniquename":"YHR193C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01641","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of the nascent polypeptide-associated complex (NAC); involved in protein sorting and translocation; associated with cytoplasmic ribosomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR193C"}


id: YHR193C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified ORF MDM31/YHR194W","secondary_identifier":"SGD:S000028785","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR193C-A"}


id: YHR194W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03395":null,"YHR194W":null},"has_protein_features":false,"name":"MDM31","ortholog_annotations":[{"gene_uniquename":"YHR194W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03395","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR194W"}


id: YHR195W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NVJ1","product":"Nuclear envelope protein; anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)","secondary_identifier":"SGD:S000001238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR195W"}


id: YHR196W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02499":null,"SJAG_02702":null,"YHR196W":null},"has_protein_features":false,"name":"UTP9","ortholog_annotations":[{"gene_uniquename":"YHR196W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02499","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR196W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02702","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR196W"}


id: YHR197W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01056":null,"YHR197W":null},"has_protein_features":false,"name":"RIX1","ortholog_annotations":[{"gene_uniquename":"YHR197W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01056","reference_uniquename":"PMID:29761456"}],"product":"Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR197W"}


id: YHR198C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM18","product":"Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss","secondary_identifier":"SGD:S000001241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR198C"}


id: YHR199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM46","product":"Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss","secondary_identifier":"SGD:S000001242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR199C"}


id: YHR199C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00697":null,"YHR199C-A":null},"has_protein_features":false,"name":"NBL1","ortholog_annotations":[{"gene_uniquename":"YHR199C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00697","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the conserved chromosomal passenger complex (CPC); complex regulates mitotic chromosome segregation; not required for the kinase activity of the complex; mediates the interaction of Sli15p and Bir1p; other complex members are Ipl1p, Sli15p, and Bir1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000029704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR199C-A"}


id: YHR200W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02992":null,"YHR200W":null},"has_protein_features":false,"name":"RPN10","ortholog_annotations":[{"gene_uniquename":"YHR200W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02992","reference_uniquename":"PMID:29761456"}],"product":"Proteasome polyubiquitin receptor; non-ATPase subunit of the 19S regulatory particle (RP) of the 26S proteasome that links the RP base to the lid; N-terminus plays a role in the assembly of the regulatory particle (RP); ubiquitin-interacting motif selectively binds to polyubiquitin chains; homolog of the mammalian S5a protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR200W"}


id: YHR201C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03964":null,"YHR201C":null},"has_protein_features":false,"name":"PPX1","ortholog_annotations":[{"gene_uniquename":"YHR201C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03964","reference_uniquename":"PMID:29761456"}],"product":"Exopolyphosphatase; hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR201C"}


id: YHR202W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02580":null,"SJAG_02582":null,"SJAG_02959":null,"YHR202W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YHR202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02580","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02582","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02959","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR202W"}


id: YHR203C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04324":null,"SJAG_04663":null,"YHR203C":null},"has_protein_features":false,"name":"RPS4B","ortholog_annotations":[{"gene_uniquename":"YHR203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04324","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04663","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR203C"}


id: YHR204W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01858":null,"YHR204W":null},"has_protein_features":false,"name":"MNL1","ortholog_annotations":[{"gene_uniquename":"YHR204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01858","reference_uniquename":"PMID:29761456"}],"product":"Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; involved in glycan trimming of both folded and misfolded glycoproteins; complexes with Pdi1p, and trims a mannose from Man8GlcNac2 glycans to generate Man7GlcNac2, an oligosaccharide signal on glycoproteins destined for ER-associated protein degradation; requires Pdi1p for stability and substrate recognition; human homolog EDEM1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR204W"}


id: YHR205W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02426":null,"SJAG_04394":null,"YHR205W":null},"has_protein_features":false,"name":"SCH9","ortholog_annotations":[{"gene_uniquename":"YHR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02426","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04394","reference_uniquename":"PMID:29761456"}],"product":"AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR205W"}


id: YHR206W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02472":null,"SJAG_04388":null,"YHR206W":null},"has_protein_features":false,"name":"SKN7","ortholog_annotations":[{"gene_uniquename":"YHR206W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02472","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR206W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04388","reference_uniquename":"PMID:29761456"}],"product":"Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; relocalizes to the cytosol in response to hypoxia; SKN7 has a paralog, HMS2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR206W"}


id: YHR207C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03630":null,"YHR207C":null},"has_protein_features":false,"name":"SET5","ortholog_annotations":[{"gene_uniquename":"YHR207C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03630","reference_uniquename":"PMID:29761456"}],"product":"Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR207C"}


id: YHR208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04149":null,"YHR208W":null},"has_protein_features":false,"name":"BAT1","ortholog_annotations":[{"gene_uniquename":"YHR208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04149","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA biosynthesis; homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase; BAT1 has a paralog, BAT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR208W"}


id: YHR209W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02973":null,"YHR209W":null},"has_protein_features":false,"name":"CRG1","ortholog_annotations":[{"gene_uniquename":"YHR209W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02973","reference_uniquename":"PMID:29761456"}],"product":"S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR209W"}


id: YHR210C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions","secondary_identifier":"SGD:S000001253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR210C"}


id: YHR211W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FLO5","product":"Lectin-like cell wall protein (flocculin) involved in flocculation; binds mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; important for co-flocculation with other yeasts, mediating interaction with specific species; FLO5 has a paralog, FLO1, that arose from a segmental duplication","secondary_identifier":"SGD:S000001254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR211W"}


id: YHR212C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YHR212C has a paralog, YAR060C, that arose from a segmental duplication","secondary_identifier":"SGD:S000001255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR212C"}


id: YHR212W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Pseudogenic fragment with similarity to flocculins; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YHR212W-A has a paralog, YAR061W, that arose from a segmental duplication","secondary_identifier":"SGD:S000028650","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR212W-A"}


id: YHR213W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Pseudogenic fragment with similarity to flocculins; YHR213W has a paralog, YAR062W, that arose from a segmental duplication","secondary_identifier":"SGD:S000001256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR213W"}


id: YHR213W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR213W-A"}


id: YHR213W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Pseudogenic fragment with similarity to flocculins; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; YHR213W-B has a paralog, YAR064W, that arose from a segmental duplication","secondary_identifier":"SGD:S000028652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR213W-B"}


id: YHR214C-D
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP and mCherry fusion proteins localize to the nucleus and endoplasmic reticulum respectively; YHR214C-D has a paralog, YAR069C, that arose from a segmental duplication","secondary_identifier":"SGD:S000028653","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR214C-D"}


id: YHR214C-E
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028654","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR214C-E"}


id: YHR214W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; predicted to be a glycosylphosphatidylinositol-modified (GPI) protein; YHR214W has a paralog, YAR066W, that arose from a segmental duplication","secondary_identifier":"SGD:S000001257","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR214W"}


id: YHR214W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; induced by zinc deficiency; YHR214W-A has a paralog, YAR068W, that arose from a segmental duplication","secondary_identifier":"SGD:S000003535","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR214W-A"}


id: YHR215W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01970":null,"SJAG_04067":null,"YHR215W":null},"has_protein_features":false,"name":"PHO12","ortholog_annotations":[{"gene_uniquename":"YHR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01970","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YHR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04067","reference_uniquename":"PMID:29761456"}],"product":"One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog, PHO11, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001258","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR215W"}


id: YHR216W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01298":null,"YHR216W":null},"has_protein_features":false,"name":"IMD2","ortholog_annotations":[{"gene_uniquename":"YHR216W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01298","reference_uniquename":"PMID:29761456"}],"product":"Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation; IMD2 has a paralog, YAR073W/YAR075W, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001259","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR216W"}


id: YHR217C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R","secondary_identifier":"SGD:S000001260","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR217C"}


id: YHR218W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Helicase-like protein encoded within the telomeric Y' element","secondary_identifier":"SGD:S000001261","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR218W"}


id: YHR218W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely within telomere TEL08L","secondary_identifier":"SGD:S000028786","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR218W-A"}


id: YHR219C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR219C-A"}


id: YHR219W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function with similarity to helicases; located in the telomere region on the right arm of chromosome VIII","secondary_identifier":"SGD:S000001262","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YHR219W"}


id: YIL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02041":null,"YIL001W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YIL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02041","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001263","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL001W"}


id: YIL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04545":null,"YIL002C":null},"has_protein_features":false,"name":"INP51","ortholog_annotations":[{"gene_uniquename":"YIL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04545","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001264","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL002C"}


id: YIL002W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CMI7","product":"Putative mitochondrial protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028835","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL002W-A"}


id: YIL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02895":null,"YIL003W":null},"has_protein_features":false,"name":"CFD1","ortholog_annotations":[{"gene_uniquename":"YIL003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02895","reference_uniquename":"PMID:29761456"}],"product":"Highly conserved iron-sulfur cluster binding protein; localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001265","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL003W"}


id: YIL004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02103":null,"YIL004C":null},"has_protein_features":false,"name":"BET1","ortholog_annotations":[{"gene_uniquename":"YIL004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02103","reference_uniquename":"PMID:29761456"}],"product":"Type II membrane protein required for vesicular transport; required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001266","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL004C"}


id: YIL005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00131":null,"SJAG_02301":null,"SJAG_04904":null,"YIL005W":null},"has_protein_features":false,"name":"EPS1","ortholog_annotations":[{"gene_uniquename":"YIL005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00131","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02301","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04904","reference_uniquename":"PMID:29761456"}],"product":"ER protein with chaperone and co-chaperone activity; involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001267","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL005W"}


id: YIL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04328":null,"YIL006W":null},"has_protein_features":false,"name":"YIA6","ortholog_annotations":[{"gene_uniquename":"YIL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04328","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial NAD+ transporter; involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs; YIA6 has a paralog, YEA6, that arose from the whole genome duplication; human NAD+ transporter MCART1/SLC25A51 functionally complements the yia6 yea6 double null mutant, and yeast YIA6 reciprocally complements defects in MCART1/SLC25A51 null cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001268","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL006W"}


id: YIL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02570":null,"YIL007C":null},"has_protein_features":false,"name":"NAS2","ortholog_annotations":[{"gene_uniquename":"YIL007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02570","reference_uniquename":"PMID:29761456"}],"product":"Evolutionarily conserved 19S regulatory particle assembly-chaperone; involved in assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress; ortholog of human p27","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001269","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL007C"}


id: YIL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03616":null,"YIL008W":null},"has_protein_features":false,"name":"URM1","ortholog_annotations":[{"gene_uniquename":"YIL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03616","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001270","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL008W"}


id: YIL009C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01378":null,"YIL009C-A":null},"has_protein_features":false,"name":"EST3","ortholog_annotations":[{"gene_uniquename":"YIL009C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01378","reference_uniquename":"PMID:29761456"}],"product":"Component of the telomerase holoenzyme; involved in telomere replication; synthesis of the full-length protein results from a programmed +1 ribosomal frameshift","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006432","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL009C-A"}


id: YIL009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03471":null,"SJAG_03909":null,"YIL009W":null},"has_protein_features":false,"name":"FAA3","ortholog_annotations":[{"gene_uniquename":"YIL009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03471","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03909","reference_uniquename":"PMID:29761456"}],"product":"Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C16:0-C18:0 chain lengths; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001271","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL009W"}


id: YIL010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02515":null,"YIL010W":null},"has_protein_features":false,"name":"DOT5","ortholog_annotations":[{"gene_uniquename":"YIL010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02515","reference_uniquename":"PMID:29761456"}],"product":"Nuclear thiol peroxidase; functions as an alkyl-hydroperoxide reductase during post-diauxic growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001272","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL010W"}


id: YIL011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TIR3","product":"Cell wall mannoprotein; member of Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; TIR3 has a paralog, TIR2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001273","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL011W"}


id: YIL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000001274","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL012W"}


id: YIL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04277":null,"YIL013C":null},"has_protein_features":false,"name":"PDR11","ortholog_annotations":[{"gene_uniquename":"YIL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"ATP-binding cassette (ABC) transporter; multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth; PDR11 has a paralog, AUS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001275","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL013C"}


id: YIL014C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000003536","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL014C-A"}


id: YIL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MNT3","product":"Alpha-1,3-mannosyltransferase; adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation","secondary_identifier":"SGD:S000001276","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL014W"}


id: YIL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BAR1","product":"Aspartyl protease secreted to periplasmic space of mating type a cell; helps cells monitor availability of mating partners; cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest","secondary_identifier":"SGD:S000001277","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL015W"}


id: YIL016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01737":null,"SJAG_04817":null,"YIL016W":null},"has_protein_features":false,"name":"SNL1","ortholog_annotations":[{"gene_uniquename":"YIL016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01737","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04817","reference_uniquename":"PMID:29761456"}],"product":"Ribosome-associated protein; proposed to act in protein synthesis, nuclear pore complex biogenesis and maintenance as well as protein folding and prion maintenance; ; has similarity to the mammalian BAG-1 protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001278","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL016W"}


id: YIL017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02197":null,"YIL017C":null},"has_protein_features":false,"name":"VID28","ortholog_annotations":[{"gene_uniquename":"YIL017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02197","reference_uniquename":"PMID:29761456"}],"product":"GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001279","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL017C"}


id: YIL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00034":null,"SJAG_02312":null,"YIL018W":null},"has_protein_features":false,"name":"RPL2B","ortholog_annotations":[{"gene_uniquename":"YIL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02312","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001280","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL018W"}


id: YIL019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01347":null,"YIL019W":null},"has_protein_features":false,"name":"FAF1","ortholog_annotations":[{"gene_uniquename":"YIL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01347","reference_uniquename":"PMID:29761456"}],"product":"Protein required for pre-rRNA processing; also required for 40S ribosomal subunit assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001281","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL019W"}


id: YIL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01346":null,"YIL020C":null},"has_protein_features":false,"name":"HIS6","ortholog_annotations":[{"gene_uniquename":"YIL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01346","reference_uniquename":"PMID:29761456"}],"product":"Enzyme that catalyzes the fourth step in the histidine pathway; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001282","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL020C"}


id: YIL020C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps origin of replication ARS918, partially overlaps ORF RPB3/YIL021W","secondary_identifier":"SGD:S000028787","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL020C-A"}


id: YIL021C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene RPB3/YIL021W; identified by gene-trapping, expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL021C-A"}


id: YIL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02506":null,"YIL021W":null},"has_protein_features":false,"name":"RPB3","ortholog_annotations":[{"gene_uniquename":"YIL021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02506","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001283","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL021W"}


id: YIL022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02077":null,"YIL022W":null},"has_protein_features":false,"name":"TIM44","ortholog_annotations":[{"gene_uniquename":"YIL022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02077","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the TIM23 complex; tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex); TIM23 complex is short for the translocase of the inner mitochondrial membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001284","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL022W"}


id: YIL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00222":null,"YIL023C":null},"has_protein_features":false,"name":"YKE4","ortholog_annotations":[{"gene_uniquename":"YIL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00222","reference_uniquename":"PMID:29761456"}],"product":"Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001285","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL023C"}


id: YIL024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p","secondary_identifier":"SGD:S000001286","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL024C"}


id: YIL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001287","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL025C"}


id: YIL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03418":null,"SJAG_03698":null,"YIL026C":null},"has_protein_features":false,"name":"IRR1","ortholog_annotations":[{"gene_uniquename":"YIL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03418","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03698","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the cohesin complex; which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms; relocalizes to the cytosol in response to hypoxia; essential for viability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001288","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL026C"}


id: YIL027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01223":null,"YIL027C":null},"has_protein_features":false,"name":"EMC5","ortholog_annotations":[{"gene_uniquename":"YIL027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01223","reference_uniquename":"PMID:29761456"}],"product":"Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001289","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL027C"}


id: YIL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001290","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL028W"}


id: YIL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EMA17","product":"Protein involved in targeting mitochondrial membrane protein precursors to mitochondrial translocation system; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has a paralog, YPR071W, that arose from a single-locus duplication","secondary_identifier":"SGD:S000001291","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL029C"}


id: YIL029W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF SSM4/YIL030C","secondary_identifier":"SGD:S000028788","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL029W-A"}


id: YIL030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03657":null,"YIL030C":null},"has_protein_features":false,"name":"SSM4","ortholog_annotations":[{"gene_uniquename":"YIL030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03657","reference_uniquename":"PMID:29761456"}],"product":"Membrane-embedded ubiquitin-protein ligase and retrotranslocase; ER and inner nuclear membrane localized RING-CH domain E3 ligase involved in ER-associated protein degradation (ERAD); aids Cdc48p in the extraction of faulty membrane proteins; targets misfolded cytosolic/nucleoplasmic domains of soluble and membrane embedded proteins (ERAD-C) and Sbh2p, a transmembrane domain-containing substrate (ERAD-M); C-terminal element, conserved in human ortholog MARCH6, determines substrate selectivity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001292","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL030C"}


id: YIL030W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF ULP2/YIL031W","secondary_identifier":"SGD:S000028789","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL030W-A"}


id: YIL031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_16454":null,"YIL031W":null},"has_protein_features":false,"name":"ULP2","ortholog_annotations":[{"gene_uniquename":"YIL031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16454","reference_uniquename":"PMID:29761456"}],"product":"Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins; plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate; human homolog PML implicated in promyelocytic leukemia can partially complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001293","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL031W"}


id: YIL032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001294","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL032C"}


id: YIL033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01245":null,"YIL033C":null},"has_protein_features":false,"name":"BCY1","ortholog_annotations":[{"gene_uniquename":"YIL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01245","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA); PKA is a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001295","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL033C"}


id: YIL034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02700":null,"YIL034C":null},"has_protein_features":false,"name":"CAP2","ortholog_annotations":[{"gene_uniquename":"YIL034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02700","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001296","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL034C"}


id: YIL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01799":null,"YIL035C":null},"has_protein_features":false,"name":"CKA1","ortholog_annotations":[{"gene_uniquename":"YIL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01799","reference_uniquename":"PMID:29761456"}],"product":"Alpha catalytic subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001297","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL035C"}


id: YIL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CST6","product":"Basic leucine zipper (bZIP) transcription factor from ATF/CREB family involved in stress-responsive regulatory network; mediates transcriptional activation of NCE103 in response to low CO2 levels; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; relocalizes to the cytosol in response to hypoxia; CST6 has a paralog, ACA1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001298","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL036W"}


id: YIL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRM2","product":"Pheromone-regulated protein; predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion","secondary_identifier":"SGD:S000001299","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL037C"}


id: YIL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04350":null,"YIL038C":null},"has_protein_features":false,"name":"NOT3","ortholog_annotations":[{"gene_uniquename":"YIL038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04350","reference_uniquename":"PMID:29761456"}],"product":"Component of the CCR4-NOT core complex, involved in mRNA decapping; involved in transcription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not3p and Not5p is mutated in cancers","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001300","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL038C"}


id: YIL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01860":null,"YIL039W":null},"has_protein_features":false,"name":"TED1","ortholog_annotations":[{"gene_uniquename":"YIL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01860","reference_uniquename":"PMID:29761456"}],"product":"GPI-glycan remodelase; conserved phosphoesterase domain-containing protein; acts together with Emp24p/Erv25p in cargo exit from the ER; functional ortholog of mammalian GPI-glycan remodelase PGAP5; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001301","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL039W"}


id: YIL040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04578":null,"YIL040W":null},"has_protein_features":false,"name":"APQ12","ortholog_annotations":[{"gene_uniquename":"YIL040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04578","reference_uniquename":"PMID:29761456"}],"product":"Nuclear envelope/ER integral membrane protein; interacts and functions with Brr6p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA export from the nucleus and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001302","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL040W"}


id: YIL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GVP36","product":"BAR domain protein that localizes to early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis","secondary_identifier":"SGD:S000001303","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL041W"}


id: YIL042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01402":null,"YIL042C":null},"has_protein_features":false,"name":"PKP1","ortholog_annotations":[{"gene_uniquename":"YIL042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01402","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein kinase; involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001304","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL042C"}


id: YIL043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00235":null,"YIL043C":null},"has_protein_features":false,"name":"CBR1","ortholog_annotations":[{"gene_uniquename":"YIL043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00235","reference_uniquename":"PMID:29761456"}],"product":"Cytochrome b reductase and NADH-dependent reductase for Dph3p; required for diphthamide synthesis and tRNA wobble uridine modification; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001305","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL043C"}


id: YIL044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01600":null,"SJAG_04724":null,"YIL044C":null},"has_protein_features":false,"name":"AGE2","ortholog_annotations":[{"gene_uniquename":"YIL044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01600","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04724","reference_uniquename":"PMID:26896847"}],"product":"ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001306","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL044C"}


id: YIL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PIG2","product":"Putative type-1 protein phosphatase targeting subunit; tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase; PIG2 has a paralog, GIP2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001307","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL045W"}


id: YIL046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00192":null,"YIL046W":null},"has_protein_features":false,"name":"MET30","ortholog_annotations":[{"gene_uniquename":"YIL046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00192","reference_uniquename":"PMID:29761456"}],"product":"F-box protein containing five copies of the WD40 motif; controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus; dissociation of Met30p from SCF complex in response to cadmium stress is regulated by Cdc48p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001308","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL046W"}


id: YIL046W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028836","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL046W-A"}


id: YIL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00233":null,"YIL047C":null},"has_protein_features":false,"name":"SYG1","ortholog_annotations":[{"gene_uniquename":"YIL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00233","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001309","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL047C"}


id: YIL047C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF SYG1/YIL047C","secondary_identifier":"SGD:S000028790","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL047C-A"}


id: YIL048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05209":null,"YIL048W":null},"has_protein_features":false,"name":"NEO1","ortholog_annotations":[{"gene_uniquename":"YIL048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05209","reference_uniquename":"PMID:29761456"}],"product":"Phospholipid translocase (flippase); involved in generating phospholipid asymmetry in the plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi-to-ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001310","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL048W"}


id: YIL049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04954":null,"YIL049W":null},"has_protein_features":false,"name":"DFG10","ortholog_annotations":[{"gene_uniquename":"YIL049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04954","reference_uniquename":"PMID:29761456"}],"product":"Probable polyprenol reductase; catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; involved in filamentous growth; mutations in human homolog SRD5A3 confer CDG (Congenital Disorders of Glycosylation); human SRD5A3 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001311","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL049W"}


id: YIL050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05978":null,"YIL050W":null},"has_protein_features":false,"name":"PCL7","ortholog_annotations":[{"gene_uniquename":"YIL050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05978","reference_uniquename":"PMID:29761456"}],"product":"Pho85p cyclin of the Pho80p subfamily; forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated; PCL7 has a paralog, PCL6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001312","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL050W"}


id: YIL051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00107":null,"YIL051C":null},"has_protein_features":false,"name":"MMF1","ortholog_annotations":[{"gene_uniquename":"YIL051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00107","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for transamination of isoleucine; but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; induction of expression in response to stress is mediated by a Hog1p-regulated antisense RNA and gene looping; interacts genetically with mitochondrial ribosomal protein genes; MMF1 has a paralog, HMF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001313","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL051C"}


id: YIL052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01853":null,"SJAG_05216":null,"YIL052C":null},"has_protein_features":false,"name":"RPL34B","ortholog_annotations":[{"gene_uniquename":"YIL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01853","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05216","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001314","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL052C"}


id: YIL053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GPP1","product":"Constitutively expressed DL-glycerol-3-phosphate phosphatase; also known as glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; GPP1 has a paralog, GPP2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001315","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL053W"}


id: YIL054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels","secondary_identifier":"SGD:S000001316","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL054W"}


id: YIL055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001317","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL055C"}


id: YIL056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VHR1","product":"Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001318","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL056W"}


id: YIL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RGI2","product":"Protein of unknown function; involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose; RGI2 has a paralog, RGI1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001319","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL057C"}


id: YIL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001320","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL058W"}


id: YIL059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W","secondary_identifier":"SGD:S000001321","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL059C"}


id: YIL060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Mitochondrial protein of unknown function; required for respiratory growth; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene","secondary_identifier":"SGD:S000001322","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL060W"}


id: YIL061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05009":null,"YIL061C":null},"has_protein_features":false,"name":"SNP1","ortholog_annotations":[{"gene_uniquename":"YIL061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05009","reference_uniquename":"PMID:29761456"}],"product":"Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001323","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL061C"}


id: YIL062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04100":null,"YIL062C":null},"has_protein_features":false,"name":"ARC15","ortholog_annotations":[{"gene_uniquename":"YIL062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04100","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001324","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL062C"}


id: YIL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03836":null,"YIL063C":null},"has_protein_features":false,"name":"YRB2","ortholog_annotations":[{"gene_uniquename":"YIL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03836","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; relocalizes to the cytosol in response to hypoxia; not essential for viability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001325","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL063C"}


id: YIL064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04159":null,"YIL064W":null},"has_protein_features":false,"name":"EFM4","ortholog_annotations":[{"gene_uniquename":"YIL064W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04159","reference_uniquename":"PMID:29761456"}],"product":"Lysine methyltransferase; involved in the dimethylation of eEF1A (Tef1p/Tef2p) at lysine 316; sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001326","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL064W"}


id: YIL065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03464":null,"YIL065C":null},"has_protein_features":false,"name":"FIS1","ortholog_annotations":[{"gene_uniquename":"YIL065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03464","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in mitochondrial fission and peroxisome abundance; may have a distinct role in tethering protein aggregates to mitochondria in order to retain them in the mother cell; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001327","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL065C"}


id: YIL066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04665":null,"YIL066C":null},"has_protein_features":false,"name":"RNR3","ortholog_annotations":[{"gene_uniquename":"YIL066C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04665","reference_uniquename":"PMID:29761456"}],"product":"Minor isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; RNR3 has a paralog, RNR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001328","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL066C"}


id: YIL066W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YIL067C","secondary_identifier":"SGD:S000028791","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL066W-A"}


id: YIL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Uncharacterized protein of unknown function","secondary_identifier":"SGD:S000001329","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL067C"}


id: YIL068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01925":null,"YIL068C":null},"has_protein_features":false,"name":"SEC6","ortholog_annotations":[{"gene_uniquename":"YIL068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01925","reference_uniquename":"PMID:29761456"}],"product":"Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; binds to SNARE complexes binteracting with Sec9p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001330","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL068C"}


id: YIL068W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF SEC6/YIL068C","secondary_identifier":"SGD:S000028792","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL068W-A"}


id: YIL069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00468":null,"SJAG_02585":null,"YIL069C":null},"has_protein_features":false,"name":"RPS24B","ortholog_annotations":[{"gene_uniquename":"YIL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00468","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02585","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001331","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL069C"}


id: YIL070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03104":null,"SJAG_03155":null,"YIL070C":null},"has_protein_features":false,"name":"MAM33","ortholog_annotations":[{"gene_uniquename":"YIL070C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03104","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL070C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03155","reference_uniquename":"PMID:29761456"}],"product":"Acidic protein of the mitochondrial matrix; binds unassembled large subunit proteins during ribosome assembly; subunit of a complex containing Mrx6p, Pim1p, and Pet20p that may regulate mtDNA replication; related to the human complement receptor gC1q-R","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001332","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL070C"}


id: YIL071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PCI8","product":"Possible shared subunit of Cop9 signalosome (CSN) and eIF3; binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain","secondary_identifier":"SGD:S000001333","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL071C"}


id: YIL071W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF PCI8/YIL071C","secondary_identifier":"SGD:S000028793","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL071W-A"}


id: YIL072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02652":null,"YIL072W":null},"has_protein_features":false,"name":"HOP1","ortholog_annotations":[{"gene_uniquename":"YIL072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02652","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein-DNA filaments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001334","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL072W"}


id: YIL073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPO22","product":"Meiosis-specific protein essential for chromosome synapsis; involved in completion of nuclear divisions during meiosis; induced early in meiosis","secondary_identifier":"SGD:S000001335","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL073C"}


id: YIL074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02313":null,"YIL074C":null},"has_protein_features":false,"name":"SER33","ortholog_annotations":[{"gene_uniquename":"YIL074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02313","reference_uniquename":"PMID:29761456"}],"product":"3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; also functions as an alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); localizes to the cytoplasm; SER33 has a paralog, SER3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001336","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL074C"}


id: YIL075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04088":null,"YIL075C":null},"has_protein_features":false,"name":"RPN2","ortholog_annotations":[{"gene_uniquename":"YIL075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04088","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001337","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL075C"}


id: YIL076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02234":null,"YIL076W":null},"has_protein_features":false,"name":"SEC28","ortholog_annotations":[{"gene_uniquename":"YIL076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02234","reference_uniquename":"PMID:29761456"}],"product":"Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001338","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL076W"}


id: YIL077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RCI37","product":"Protein that associates with the large mitoribosomal subunit; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)","secondary_identifier":"SGD:S000001339","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL077C"}


id: YIL078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01235":null,"YIL078W":null},"has_protein_features":false,"name":"THS1","ortholog_annotations":[{"gene_uniquename":"YIL078W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01235","reference_uniquename":"PMID:29761456"}],"product":"Threonyl-tRNA synthetase; essential cytoplasmic protein; human homolog TARS can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001340","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL078W"}


id: YIL079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03984":null,"YIL079C":null},"has_protein_features":false,"name":"AIR1","ortholog_annotations":[{"gene_uniquename":"YIL079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03984","reference_uniquename":"PMID:29761456"}],"product":"Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication; although Air1p and Air2p are homologous TRAMP subunits, they have nonredundant roles in regulation of substrate specificity of the exosome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001341","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL079C"}


id: YIL082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag","secondary_identifier":"SGD:S000001344","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL082W"}


id: YIL083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01139":null,"YIL083C":null},"has_protein_features":false,"name":"CAB2","ortholog_annotations":[{"gene_uniquename":"YIL083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01139","reference_uniquename":"PMID:29761456"}],"product":"Phosphopantothenoylcysteine synthetase (PPCS); catalyzes the second step of coenzyme A biosynthesis from pantothenate; subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) that contains: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p subunits; null mutant lethality is complemented by human homolog PPCS and by E. coli coaBC, a bifunctional enzyme with PPCS activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001345","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL083C"}


id: YIL084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02981":null,"YIL084C":null},"has_protein_features":false,"name":"SDS3","ortholog_annotations":[{"gene_uniquename":"YIL084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02981","reference_uniquename":"PMID:29761456"}],"product":"Component of the Rpd3L histone deacetylase complex; required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; relocalizes to the cytosol in response to hypoxia; cells defective in SDS3 display pleiotropic phenotypes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001346","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL084C"}


id: YIL085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02519":null,"SJAG_03082":null,"YIL085C":null},"has_protein_features":false,"name":"KTR7","ortholog_annotations":[{"gene_uniquename":"YIL085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02519","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03082","reference_uniquename":"PMID:29761456"}],"product":"Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001347","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL085C"}


id: YIL086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000001348","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL086C"}


id: YIL087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01155":null,"YIL087C":null},"has_protein_features":false,"name":"AIM19","ortholog_annotations":[{"gene_uniquename":"YIL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01155","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; mitochondrial protein that physically interacts with Tim23p; null mutant displays reduced respiratory growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001349","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL087C"}


id: YIL088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03256":null,"YIL088C":null},"has_protein_features":false,"name":"AVT7","ortholog_annotations":[{"gene_uniquename":"YIL088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03256","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar amino acid transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001350","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL088C"}


id: YIL089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking","secondary_identifier":"SGD:S000001351","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL089W"}


id: YIL090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02683":null,"YIL090W":null},"has_protein_features":false,"name":"ICE2","ortholog_annotations":[{"gene_uniquename":"YIL090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02683","reference_uniquename":"PMID:29761456"}],"product":"Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; required for post-translational SRP-independent protein translocation into the ER; necessary for efficient targeting of Trm1p tRNA methyltransferase to the inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001352","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL090W"}


id: YIL091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00945":null,"YIL091C":null},"has_protein_features":false,"name":"UTP25","ortholog_annotations":[{"gene_uniquename":"YIL091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00945","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001353","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL091C"}


id: YIL092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus","secondary_identifier":"SGD:S000001354","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL092W"}


id: YIL093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04378":null,"YIL093C":null},"has_protein_features":false,"name":"RSM25","ortholog_annotations":[{"gene_uniquename":"YIL093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04378","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001355","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL093C"}


id: YIL094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00502":null,"YIL094C":null},"has_protein_features":false,"name":"LYS12","ortholog_annotations":[{"gene_uniquename":"YIL094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00502","reference_uniquename":"PMID:29761456"}],"product":"Homo-isocitrate dehydrogenase; an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001356","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL094C"}


id: YIL095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00649":null,"SJAG_04052":null,"SJAG_04465":null,"YIL095W":null},"has_protein_features":false,"name":"PRK1","ortholog_annotations":[{"gene_uniquename":"YIL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00649","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04052","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04465","reference_uniquename":"PMID:29761456"}],"product":"Ser/Thr protein kinase; regulates the organization and function of the actin cytoskeleton; inhibits clathrin-mediated endocytosis; phosphorylates the Pan1p and Sla1p subunits of the Pan1p-Sla1p-End3p complex, resulting in inhibition of complex formation; inhibits Scd5p through phosphorylation; phosphorylates Pan1p-interacting proteins, Ent1/2 and Yap1801/2; negatively regulated through autophosphorylation; functional overlap with ARK1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001357","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL095W"}


id: YIL096C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03008":null,"YIL096C":null},"has_protein_features":false,"name":"BMT5","ortholog_annotations":[{"gene_uniquename":"YIL096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03008","reference_uniquename":"PMID:29761456"}],"product":"Methyltransferase required for m3U2634 methylation of the 25S rRNA; S-adenosylmethionine-dependent; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001358","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL096C"}


id: YIL097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04309":null,"YIL097W":null},"has_protein_features":false,"name":"FYV10","ortholog_annotations":[{"gene_uniquename":"YIL097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04309","reference_uniquename":"PMID:29761456"}],"product":"Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001359","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL097W"}


id: YIL098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06135":null,"YIL098C":null},"has_protein_features":false,"name":"FMC1","ortholog_annotations":[{"gene_uniquename":"YIL098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06135","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial matrix protein; required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001360","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL098C"}


id: YIL099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02076":null,"YIL099W":null},"has_protein_features":false,"name":"SGA1","ortholog_annotations":[{"gene_uniquename":"YIL099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02076","reference_uniquename":"PMID:29761456"}],"product":"Intracellular sporulation-specific glucoamylase; involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001361","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL099W"}


id: YIL100C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000028794","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL100C-A"}


id: YIL100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A","secondary_identifier":"SGD:S000001362","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL100W"}


id: YIL101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"XBP1","product":"Transcriptional repressor; binds promoter sequences of cyclin genes, CYS3, and SMF2; not expressed during log phase of growth, but induced by stress or starvation during mitosis, and late in meiosis; represses 15% of all yeast genes as cells transition to quiescence; important for maintaining G1 arrest and for longevity of quiescent cells; member of Swi4p/Mbp1p family; phosphorylated by Cdc28p; relative distribution to nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000001363","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL101C"}


id: YIL102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001364","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL102C"}


id: YIL102C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05219":null,"YIL102C-A":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YIL102C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05219","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of dolichyl phosphate mannose (DPM) synthase; identified based on comparisons of the genome sequences of six Saccharomyces species; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000113587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL102C-A"}


id: YIL103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01058":null,"YIL103W":null},"has_protein_features":false,"name":"DPH1","ortholog_annotations":[{"gene_uniquename":"YIL103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01058","reference_uniquename":"PMID:29761456"}],"product":"Protein required for synthesis of diphthamide; required along with Dph2p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); forms a complex with Dph2p that catalyzes the first step of diphthamide biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001365","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL103W"}


id: YIL104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03551":null,"YIL104C":null},"has_protein_features":false,"name":"SHQ1","ortholog_annotations":[{"gene_uniquename":"YIL104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03551","reference_uniquename":"PMID:29761456"}],"product":"Chaperone protein; required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing; functions as an RNA mimic; forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001366","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL104C"}


id: YIL105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02989":null,"YIL105C":null},"has_protein_features":false,"name":"SLM1","ortholog_annotations":[{"gene_uniquename":"YIL105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02989","reference_uniquename":"PMID:29761456"}],"product":"Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; TORC2 complex substrate and effector; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001367","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL105C"}


id: YIL105W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; completely overlaps the verified gene SLM1; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; mRNA identified as translated by ribosome profiling data","secondary_identifier":"SGD:S000028657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL105W-A"}


id: YIL106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03936":null,"YIL106W":null},"has_protein_features":false,"name":"MOB1","ortholog_annotations":[{"gene_uniquename":"YIL106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03936","reference_uniquename":"PMID:29761456"}],"product":"Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001368","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL106W"}


id: YIL107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02596":null,"SJAG_03336":null,"YIL107C":null},"has_protein_features":false,"name":"PFK26","ortholog_annotations":[{"gene_uniquename":"YIL107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02596","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03336","reference_uniquename":"PMID:29761456"}],"product":"6-phosphofructo-2-kinase; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001369","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL107C"}


id: YIL108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03407":null,"YIL108W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YIL108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03407","reference_uniquename":"PMID:29761456"}],"product":"Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001370","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL108W"}


id: YIL109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00072":null,"YIL109C":null},"has_protein_features":false,"name":"SEC24","ortholog_annotations":[{"gene_uniquename":"YIL109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00072","reference_uniquename":"PMID:29761456"}],"product":"Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SEC24 has a paralog, SFB2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001371","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL109C"}


id: YIL110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02868":null,"YIL110W":null},"has_protein_features":false,"name":"HPM1","ortholog_annotations":[{"gene_uniquename":"YIL110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02868","reference_uniquename":"PMID:29761456"}],"product":"AdoMet-dependent methyltransferase; involved in a novel 3-methylhistidine modification of multiple proteins, including ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001372","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL110W"}


id: YIL111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01077":null,"YIL111W":null},"has_protein_features":false,"name":"COX5B","ortholog_annotations":[{"gene_uniquename":"YIL111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01077","reference_uniquename":"PMID:29761456"}],"product":"Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001373","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL111W"}


id: YIL112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HOS4","product":"Subunit of the Set3 complex; complex is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate","secondary_identifier":"SGD:S000001374","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL112W"}


id: YIL113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03263":null,"YIL113W":null},"has_protein_features":false,"name":"SDP1","ortholog_annotations":[{"gene_uniquename":"YIL113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03263","reference_uniquename":"PMID:29761456"}],"product":"Stress-inducible dual-specificity MAP kinase phosphatase; negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock; SDP1 has a paralog, MSG5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001375","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL113W"}


id: YIL114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00048":null,"YIL114C":null},"has_protein_features":false,"name":"POR2","ortholog_annotations":[{"gene_uniquename":"YIL114C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00048","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001376","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL114C"}


id: YIL115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01013":null,"YIL115C":null},"has_protein_features":false,"name":"NUP159","ortholog_annotations":[{"gene_uniquename":"YIL115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01013","reference_uniquename":"PMID:29761456"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001377","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL115C"}


id: YIL115W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUP159/YIL115C","secondary_identifier":"SGD:S000028795","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL115W-A"}


id: YIL116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03055":null,"YIL116W":null},"has_protein_features":false,"name":"HIS5","ortholog_annotations":[{"gene_uniquename":"YIL116W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03055","reference_uniquename":"PMID:29761456"}],"product":"Histidinol-phosphate aminotransferase; catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL116W"}


id: YIL117C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRM5","product":"Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling; PRM5 has a paralog, YNL058C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL117C"}


id: YIL118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02366":null,"YIL118W":null},"has_protein_features":false,"name":"RHO3","ortholog_annotations":[{"gene_uniquename":"YIL118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02366","reference_uniquename":"PMID:29761456"}],"product":"Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL118W"}


id: YIL119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RPI1","product":"Transcription factor, allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF","secondary_identifier":"SGD:S000001381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL119C"}


id: YIL120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"QDR1","product":"Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in spore wall assembly; sequence similarity to DTR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL120W"}


id: YIL121W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"QDR2","product":"Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper","secondary_identifier":"SGD:S000001383","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL121W"}


id: YIL122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"POG1","product":"DNA-binding transcriptional activator; involved in cell cycle regulation; overexpression promotes recovery from pheromone induced arrest via CLN1/2 transcription, induction of of IME1 during sporulation, and suppression of stress sensitivity resulting from mutation of the E3 ubiquitin ligase Rsp5p; binds upstream of BAR1 and cell cycle-related genes; phosphorylated form may be ubiquitinated by Dma2p; potential Cdc28p substrate; regulated by Swi4/6 cell-cycle box binding factor (SBF)","secondary_identifier":"SGD:S000001384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL122W"}


id: YIL123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02649":null,"SJAG_03295":null,"YIL123W":null},"has_protein_features":false,"name":"SIM1","ortholog_annotations":[{"gene_uniquename":"YIL123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02649","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03295","reference_uniquename":"PMID:29761456"}],"product":"Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p); may participate in DNA replication; promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated; SIM1 has a paralog, SUN4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL123W"}


id: YIL124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01036":null,"YIL124W":null},"has_protein_features":false,"name":"AYR1","ortholog_annotations":[{"gene_uniquename":"YIL124W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01036","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional triacylglycerol lipase and 1-acyl DHAP reductase; NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase involved in phosphatidic acid biosynthesis; lipid droplet triacylglycerol lipase involved in mobilization of non-polar lipids; found in lipid particles, endoplasmic reticulum and mitochondrial outer membrane; forms NADPH-regulated channel in mitochondrial outer membrane; required for spore germination; role in cell wall biosynthesis; capable of metabolizing steroid hormones","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL124W"}


id: YIL125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02464":null,"YIL125W":null},"has_protein_features":false,"name":"KGD1","ortholog_annotations":[{"gene_uniquename":"YIL125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02464","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex; catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL125W"}


id: YIL126W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04755":null,"SJAG_05313":null,"YIL126W":null},"has_protein_features":false,"name":"STH1","ortholog_annotations":[{"gene_uniquename":"YIL126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04755","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05313","reference_uniquename":"PMID:29761456"}],"product":"ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; promotes base excision repair in chromatin; essential helicase-related protein homologous to Snf2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL126W"}


id: YIL127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRT14","product":"Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis","secondary_identifier":"SGD:S000001389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL127C"}


id: YIL128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02866":null,"YIL128W":null},"has_protein_features":false,"name":"MET18","ortholog_annotations":[{"gene_uniquename":"YIL128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02866","reference_uniquename":"PMID:29761456"}],"product":"Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation and maturation of a subset of cytosolic and nuclear proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL128W"}


id: YIL129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03637":null,"YIL129C":null},"has_protein_features":false,"name":"TAO3","ortholog_annotations":[{"gene_uniquename":"YIL129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03637","reference_uniquename":"PMID:29761456"}],"product":"Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL129C"}


id: YIL130W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05343":null,"YIL130W":null},"has_protein_features":false,"name":"ASG1","ortholog_annotations":[{"gene_uniquename":"YIL130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05343","reference_uniquename":"PMID:29761456"}],"product":"Zinc cluster protein proposed to be a transcriptional regulator; regulator involved in the stress response; regulates utilization of fatty acids and accumulation of lipids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL130W"}


id: YIL131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04813":null,"YIL131C":null},"has_protein_features":false,"name":"FKH1","ortholog_annotations":[{"gene_uniquename":"YIL131C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04813","reference_uniquename":"PMID:29761456"}],"product":"Forkhead family transcription factor; rate-limiting replication origin activator; evolutionarily conserved lifespan regulator; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; regulates transcription elongation, chromatin silencing at mating loci, expression of G2/M phase genes; facilitates clustering, activation of early-firing replication origins; binds HML recombination enhancer, regulates donor preference during mating-type switching","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL131C"}


id: YIL132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSM2","product":"Subunit of the Shu complex (aka PCSS complex); Shu complex also includes Psy3, Shu1, Shu2, and promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p anti-recombinase function; promotes formation of Rad51p filaments; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis","secondary_identifier":"SGD:S000001394","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL132C"}


id: YIL133C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02207":null,"SJAG_04160":null,"YIL133C":null},"has_protein_features":false,"name":"RPL16A","ortholog_annotations":[{"gene_uniquename":"YIL133C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02207","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL133C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04160","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001395","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL133C"}


id: YIL134C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028556","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL134C-A"}


id: YIL134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03503":null,"YIL134W":null},"has_protein_features":false,"name":"FLX1","ortholog_annotations":[{"gene_uniquename":"YIL134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03503","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial flavin adenine dinucleotide transporter; FAD is a synthesis product of riboflavin; human homolog SLC25A32 is implicated in multiple acyl-CoA dehydrogenase deficiency (MADD) or glutaric aciduria type II (GAII), and can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001396","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL134W"}


id: YIL135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VHS2","product":"Regulator of septin dynamics; involved in the regulation of septin dynamics at bud neck after mitotic entry, likely by stabilizing septin structure; regulated at post-translational level by cell cycle dependent phosphorylation; likely phosphorylated by Cdc28p and dephosphorylated by Cdc14p before cytokinesis; high-copy suppressor of synthetic lethality of sis2 sit4 double mutant; VHS2 has a paralog, MLF3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001397","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL135C"}


id: YIL136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OM45","product":"Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, extending into the intermembrane space; interacts with porin (Por1p) and with Om14p; imported via the presequence pathway involving the TOM and TIM23 complexes, then assembled in the outer membrane by Mim1p; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000001398","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL136W"}


id: YIL137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00181":null,"YIL137C":null},"has_protein_features":false,"name":"TMA108","ortholog_annotations":[{"gene_uniquename":"YIL137C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00181","reference_uniquename":"PMID:29761456"}],"product":"Ribosome-associated, nascent chain binding factor; binds N-terminal region of nascent peptides during translation; recognizes target proteins via its putative metallopeptidase peptide-binding pocket","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001399","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL137C"}


id: YIL138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04887":null,"YIL138C":null},"has_protein_features":false,"name":"TPM2","ortholog_annotations":[{"gene_uniquename":"YIL138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04887","reference_uniquename":"PMID:29761456"}],"product":"Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001400","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL138C"}


id: YIL139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00611":null,"YIL139C":null},"has_protein_features":false,"name":"REV7","ortholog_annotations":[{"gene_uniquename":"YIL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00611","reference_uniquename":"PMID:29761456"}],"product":"Accessory subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; may be involved in meiosis; forms a complex with Rev3p, Pol31p and Pol32p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001401","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL139C"}


id: YIL140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AXL2","product":"Integral plasma membrane protein; required for axial budding in haploid cells; localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate","secondary_identifier":"SGD:S000001402","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL140W"}


id: YIL141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001403","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL141W"}


id: YIL142C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF CCT2/YIL142W","secondary_identifier":"SGD:S000028796","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL142C-A"}


id: YIL142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01002":null,"YIL142W":null},"has_protein_features":false,"name":"CCT2","ortholog_annotations":[{"gene_uniquename":"YIL142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01002","reference_uniquename":"PMID:29761456"}],"product":"Subunit beta of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001404","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL142W"}


id: YIL143C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03206":null,"YIL143C":null},"has_protein_features":false,"name":"SSL2","ortholog_annotations":[{"gene_uniquename":"YIL143C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03206","reference_uniquename":"PMID:29761456"}],"product":"Component of RNA polymerase transcription factor TFIIH holoenzyme; acts as dsDNA-dependent translocase in context of TFIIH, unwinds DNA strands during initiation and promotes transcription start site (TSS) scanning; has DNA-dependent ATPase/helicase activity; interacts functionally with TFIIB, has roles in TSS selection and gene looping to juxtapose initiation and termination regions; involved in DNA repair; relocalizes to cytosol under hypoxia; homolog of human ERCC3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001405","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL143C"}


id: YIL144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04076":null,"YIL144W":null},"has_protein_features":false,"name":"NDC80","ortholog_annotations":[{"gene_uniquename":"YIL144W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04076","reference_uniquename":"PMID:29761456"}],"product":"Component of the kinetochore-associated Ndc80 complex; conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, and kinetochore assembly and clustering; evolutionarily conserved; complex members include Ndc80p, Nuf2p, Scp24p, and Spc25p; modified by sumoylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001406","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL144W"}


id: YIL145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03679":null,"YIL145C":null},"has_protein_features":false,"name":"PAN6","ortholog_annotations":[{"gene_uniquename":"YIL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03679","reference_uniquename":"PMID:29761456"}],"product":"Pantothenate synthase; also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001407","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL145C"}


id: YIL146C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG32","product":"Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane; regulates mitophagy and ethanol production during alcoholic fermentation","secondary_identifier":"SGD:S000001408","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL146C"}


id: YIL147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00331":null,"SJAG_01587":null,"SJAG_02183":null,"YIL147C":null},"has_protein_features":false,"name":"SLN1","ortholog_annotations":[{"gene_uniquename":"YIL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00331","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01587","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02183","reference_uniquename":"PMID:29761456"}],"product":"Transmembrane histidine phosphotransfer kinase and osmosensor; regulates MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001409","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL147C"}


id: YIL148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01365":null,"SJAG_02891":null,"SJAG_03971":null,"YIL148W":null},"has_protein_features":false,"name":"RPL40A","ortholog_annotations":[{"gene_uniquename":"YIL148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01365","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02891","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03971","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001410","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL148W"}


id: YIL149C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03300":null,"SJAG_04645":null,"YIL149C":null},"has_protein_features":false,"name":"MLP2","ortholog_annotations":[{"gene_uniquename":"YIL149C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03300","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YIL149C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04645","reference_uniquename":"PMID:29761456"}],"product":"Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; MLP2 has a paralog, MLP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001411","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL149C"}


id: YIL150C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00399":null,"YIL150C":null},"has_protein_features":false,"name":"MCM10","ortholog_annotations":[{"gene_uniquename":"YIL150C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00399","reference_uniquename":"PMID:29761456"}],"product":"Essential chromatin-associated protein; involved in initiation of DNA replication; required for association of MCM2-7 complex with replication origins; required to stabilize catalytic subunit of DNA polymerase-alpha; coordinates function of replication fork helicase; self-associates through its N-terminal domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001412","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL150C"}


id: YIL151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01720":null,"YIL151C":null},"has_protein_features":false,"name":"ESL1","ortholog_annotations":[{"gene_uniquename":"YIL151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01720","reference_uniquename":"PMID:29761456"}],"product":"hEST1A/B (SMG5/6)-like protein; contributes to environment-sensing adaptive gene expression responses; Esl1p and Esl2p contain a 14-3-3-like domain and a putative PilT N-terminus ribonuclease domain; ESL1 has a paralog, ESL2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001413","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL151C"}


id: YIL152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001414","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL152W"}


id: YIL153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01270":null,"YIL153W":null},"has_protein_features":false,"name":"RRD1","ortholog_annotations":[{"gene_uniquename":"YIL153W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01270","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001415","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL153W"}


id: YIL154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IMP21","product":"Transcriptional activator involved in maintenance of ion homeostasis; also involved in protection against DNA damage caused by bleomycin and other oxidants; contains a C-terminal leucine-rich repeat","secondary_identifier":"SGD:S000001416","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL154C"}


id: YIL155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GUT2","product":"Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner","secondary_identifier":"SGD:S000001417","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL155C"}


id: YIL156W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00742":null,"YIL156W":null},"has_protein_features":false,"name":"UBP7","ortholog_annotations":[{"gene_uniquename":"YIL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00742","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; involved in cell cycle progression through S phase; UBP7 has a paralog, UBP11, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001418","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL156W"}


id: YIL156W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF COA1/YIL157C","secondary_identifier":"SGD:S000028797","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL156W-A"}


id: YIL156W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05261":null,"YIL156W-B":null},"has_protein_features":false,"name":"MCO8","ortholog_annotations":[{"gene_uniquename":"YIL156W-B","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05261","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein of unknown function; originally identified based on homology to <i>Ashbya gossypii</i> and other related yeasts; SWAT-GFP and mCherry fusion proteins localize to the vacuole, while SWAT-GFP fusion also localizes to the endoplasmic reticulum","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028511","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL156W-B"}


id: YIL157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04603":null,"YIL157C":null},"has_protein_features":false,"name":"COA1","ortholog_annotations":[{"gene_uniquename":"YIL157C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04603","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein; required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001419","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL157C"}


id: YIL158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM20","product":"Protein of unknown function; overexpression causes cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress; AIM20 has a paralog, SKG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001420","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL158W"}


id: YIL159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00279":null,"SJAG_01943":null,"YIL159W":null},"has_protein_features":false,"name":"BNR1","ortholog_annotations":[{"gene_uniquename":"YIL159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00279","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YIL159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01943","reference_uniquename":"PMID:29761456"}],"product":"Formin; nucleates the formation of linear actin filaments; involved in processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables; activity is regulated by Hof1p and by the Bud14p-Kel1p-Kel2p complex; dephosphorylated and delocalized from the division site in a Glc7p/Ref2p-dependent manner; functionally redundant with BNI1","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL159W"}


id: YIL160C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"POT1","product":"3-ketoacyl-CoA thiolase with broad chain length specificity; cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids","secondary_identifier":"SGD:S000001422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL160C"}


id: YIL161W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene","secondary_identifier":"SGD:S000001423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL161W"}


id: YIL162W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04301":null,"YIL162W":null},"has_protein_features":false,"name":"SUC2","ortholog_annotations":[{"gene_uniquename":"YIL162W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04301","reference_uniquename":"PMID:29761456"}],"product":"Invertase; sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001424","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL162W"}


id: YIL163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data","secondary_identifier":"SGD:S000001425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL163C"}


id: YIL164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NIT1","product":"Nitrilase; member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene","secondary_identifier":"SGD:S000001426","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL164C"}


id: YIL165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene","secondary_identifier":"SGD:S000001427","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL165C"}


id: YIL166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SOA1","product":"Sulfonate and inorganic sulfur transporter; low affinity sulfate, high affinity sulfite, thiosulfite and major sulfonate transporter; functions as a an H+ symporter; similar to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; non-essential gene","secondary_identifier":"SGD:S000001428","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL166C"}


id: YIL167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SDL1","product":"Blocked reading frame otherwise encoding L-serine dehydratase","secondary_identifier":"SGD:S000001429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL167W"}


id: YIL169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSS1","product":"Protein of unknown function, secreted when constitutively expressed; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cell periphery, SWAT-GFP fusion also localizes to the extracellular region, and mCherry fusion also localizes to the vacuole; S/T rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; non-essential gene","secondary_identifier":"SGD:S000001431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL169C"}


id: YIL171W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF IMA3/YIL172C","secondary_identifier":"SGD:S000028798","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL171W-A"}


id: YIL172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IMA3","product":"Alpha-glucosidase; weak, but broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima3p overexpression allows the ima1 null mutant to grow on isomaltose; lower activitiy and thermostability in vitro than Ima2p despite sequence difference of only 3 amino acids; cleaves alpha-1,3 linkage of nigerose and turanose, but not alpha-1,5 of leucrose; identical to IMA4","secondary_identifier":"SGD:S000001434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL172C"}


id: YIL173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01488":null,"YIL173W":null},"has_protein_features":false,"name":"VTH1","ortholog_annotations":[{"gene_uniquename":"YIL173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01488","reference_uniquename":"PMID:29761456"}],"product":"Putative membrane glycoprotein; has strong similarity to Vth2p and Pep1p/Vps10p; may be involved in vacuolar protein sorting","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL173W"}


id: YIL176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU14","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau1p","secondary_identifier":"SGD:S000001438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL176C"}


id: YIL177C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative Y' element ATP-dependent helicase","secondary_identifier":"SGD:S000001439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL177C"}


id: YIL177W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YIL177C","secondary_identifier":"SGD:S000028658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL177W-A"}


id: YIR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04601":null,"YIR001C":null},"has_protein_features":false,"name":"SGN1","ortholog_annotations":[{"gene_uniquename":"YIR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04601","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic RNA-binding protein; contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001440","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR001C"}


id: YIR002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02294":null,"SJAG_02690":null,"YIR002C":null},"has_protein_features":false,"name":"MPH1","ortholog_annotations":[{"gene_uniquename":"YIR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02294","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02690","reference_uniquename":"PMID:29761456"}],"product":"3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds flap DNA, stimulates activity of Rad27p and Dna2p; prevents crossovers between ectopic sequences by removing substrates for Mus81-Mms4 or Rad1-Rad10 cleavage; homolog of human FANCM Fanconi anemia protein that is involved in stabilizing and remodeling blocked replication forks; member of SF2 DExD/H superfamily of helicases; nonsense or missense mutations in FANCM can make people more likely to get cancer","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR002C"}


id: YIR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04172":null,"YIR003W":null},"has_protein_features":false,"name":"AIM21","ortholog_annotations":[{"gene_uniquename":"YIR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04172","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a complex that associates with actin filaments; forms a complex with Tda2p that inhibits barbed end F-actin assembly; elevates actin monomer pools to increase endocytotic efficiency and to regulate the distribution of actin between cables and patches; Aim21p/Tda2p forms a larger complex with actin capping proteins Cap1p and Cap2p; involved in mitochondrial migration along actin filaments; recruited to cortical actin patches by SH3 domain-containing proteins Bbc1p and Abp1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001442","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR003W"}


id: YIR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02034":null,"SJAG_02797":null,"YIR004W":null},"has_protein_features":false,"name":"DJP1","ortholog_annotations":[{"gene_uniquename":"YIR004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02797","reference_uniquename":"PMID:29761456"}],"product":"ER-associated chaperone involved in protein targeting; redirects mitochondrial membrane protein precursors to mitochondrial translocation system; required for peroxisomal protein import and involved in peroxisome assembly; facilitates import of Mim1p and Mim2p into the mitochondrial outer membrane; homologous to E. coli DnaJ","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001443","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR004W"}


id: YIR005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00313":null,"YIR005W":null},"has_protein_features":false,"name":"IST3","ortholog_annotations":[{"gene_uniquename":"YIR005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00313","reference_uniquename":"PMID:29761456"}],"product":"Component of the U2 snRNP; required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing; diploid mutants have a specific defect in MATa1 pre-mRNA splicing which leads to haploid gene expression in diploids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001444","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR005W"}


id: YIR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04886":null,"YIR006C":null},"has_protein_features":false,"name":"PAN1","ortholog_annotations":[{"gene_uniquename":"YIR006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04886","reference_uniquename":"PMID:29761456"}],"product":"Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p; associates with actin patches on cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates Arp2/3 complex in vitro; phosphorylation of Thr-1225 is regulated by MAPK Hog1p in response to osmotic stress; previously thought to be a subunit of poly(A) ribonuclease","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001445","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR006C"}


id: YIR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EGH1","product":"Steryl-beta-glucosidase with broad specificity for aglycones; has a role in ergosteryl-beta-glucoside catabolism; required for normal vacuolar morphology; has similarity to the C. neoformans ergosteryl-beta-glucosidase EGCrP2; localizes to the cytosol","secondary_identifier":"SGD:S000001446","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR007W"}


id: YIR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04994":null,"YIR008C":null},"has_protein_features":false,"name":"PRI1","ortholog_annotations":[{"gene_uniquename":"YIR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04994","reference_uniquename":"PMID:29761456"}],"product":"Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001447","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR008C"}


id: YIR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03547":null,"YIR009W":null},"has_protein_features":false,"name":"MSL1","ortholog_annotations":[{"gene_uniquename":"YIR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03547","reference_uniquename":"PMID:29761456"}],"product":"U2B component of U2 snRNP; involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001448","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR009W"}


id: YIR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02346":null,"YIR010W":null},"has_protein_features":false,"name":"DSN1","ortholog_annotations":[{"gene_uniquename":"YIR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02346","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the outer kinetochore MIND complex; joins kinetochore subunits contacting DNA to those contacting microtubules; phosphorylation promotes interaction between outer and inner kinetochore proteins; kinetochore receptor for monopolin, via interaction with Csm1p; essential for both meiotic and mitotic chromosome segregation; MIND complex consists of Mtw1p, Nnf1p, Nsl1p and Dsn1p; phosphorylated by monopolin subunit, Hrr25p and Aurora kinase, Ipl1p; modified by sumoylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001449","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR010W"}


id: YIR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00054":null,"YIR011C":null},"has_protein_features":false,"name":"STS1","ortholog_annotations":[{"gene_uniquename":"YIR011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00054","reference_uniquename":"PMID:29761456"}],"product":"Protein required for localizing proteasomes to the nucleus; involved in cotranslational protein degradation; mediates interaction between nuclear import factor Srp1p and the proteasome; Sts1p and Srp1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation; involved in ubiquitin-mediated protein degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001450","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR011C"}


id: YIR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02436":null,"YIR012W":null},"has_protein_features":false,"name":"SQT1","ortholog_annotations":[{"gene_uniquename":"YIR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02436","reference_uniquename":"PMID:29761456"}],"product":"Specific assembly chaperone for ribosomal protein Rpl10p; co-translationally associates with nascent Rpl10p, preventing aggregation; involved in biogenesis of the ribosomal large subunit; contains multiple WD repeats; interacts genetically and physically with Qsr1p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001451","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR012W"}


id: YIR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GAT4","product":"Protein containing GATA family zinc finger motifs; involved in spore wall assembly; sequence similarity to GAT3, and the double mutant gat3 gat4 exhibits reduced dityrosine fluorescence relative to the single mutants","secondary_identifier":"SGD:S000001452","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR013C"}


id: YIR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VLD1","product":"Component of Dsc E3 ligase complex in vacuolar membranes; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene","secondary_identifier":"SGD:S000001453","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR014W"}


id: YIR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00306":null,"YIR015W":null},"has_protein_features":false,"name":"RPR2","ortholog_annotations":[{"gene_uniquename":"YIR015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00306","reference_uniquename":"PMID:29761456"}],"product":"Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001454","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR015W"}


id: YIR016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR016W"}


id: YIR017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04749":null,"YIR017C":null},"has_protein_features":false,"name":"MET28","ortholog_annotations":[{"gene_uniquename":"YIR017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04749","reference_uniquename":"PMID:29761456"}],"product":"bZIP transcriptional activator in the Cbf1p-Met4p-Met28p complex; participates in the regulation of sulfur metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001456","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR017C"}


id: YIR017W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000028799","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR017W-A"}


id: YIR018C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028837","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR018C-A"}


id: YIR018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YAP5","product":"Basic leucine zipper (bZIP) iron-sensing transcription factor; senses high-iron conditions via two Fe/S clusters bound to its activator domain; involved in diauxic shift; YAP5 has a paralog, YAP7, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001457","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR018W"}


id: YIR019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FLO11","product":"GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal and invasive growth, flocculation, and biofilm formation; major determinant of colony morphology; QTL that controls chronological life span; carries intragenic tandem repeats that are expanded in different strains; required for formation of fibrous interconnections between cells; role in co-flocculation with other yeast species; cleaved and shed from cells, contributing to their surface properties","secondary_identifier":"SGD:S000001458","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR019C"}


id: YIR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data; SWAT-GFP fusion protein localizes to the endoplasmic reticulum","secondary_identifier":"SGD:S000001459","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR020C"}


id: YIR020C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF MRS1","secondary_identifier":"SGD:S000028800","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR020C-B"}


id: YIR020W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR020W-A"}


id: YIR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRS1","product":"Splicing protein; required for splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA; MRS1 has a paralog, CCE1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001460","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR021W"}


id: YIR021W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028838","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR021W-A"}


id: YIR022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03261":null,"YIR022W":null},"has_protein_features":false,"name":"SEC11","ortholog_annotations":[{"gene_uniquename":"YIR022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03261","reference_uniquename":"PMID:29761456"}],"product":"18kDa catalytic subunit of the Signal Peptidase Complex (SPC); the Signal Peptidase Complex cleaves the signal sequence of proteins targeted to the endoplasmic reticulum; other members are Spc1p, Spc2p, Spc3p, and Sec11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001461","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR022W"}


id: YIR023C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF DAL81/YIR023W","secondary_identifier":"SGD:S000028801","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR023C-A"}


id: YIR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DAL81","product":"Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism","secondary_identifier":"SGD:S000001462","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR023W"}


id: YIR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"INA22","product":"F1F0 ATP synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex (Ina22p-Ina17p) involved in assembly of the F1F0 peripheral stalk; co-purifies with Aim43p, ATP synthase subunits, and cytochrome bc1 complex assembly factors; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect","secondary_identifier":"SGD:S000001463","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR024C"}


id: YIR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03037":null,"YIR025W":null},"has_protein_features":false,"name":"MND2","ortholog_annotations":[{"gene_uniquename":"YIR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03037","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001464","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR025W"}


id: YIR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01161":null,"YIR026C":null},"has_protein_features":false,"name":"YVH1","ortholog_annotations":[{"gene_uniquename":"YIR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01161","reference_uniquename":"PMID:29761456"}],"product":"Dual specificity protein phosphatase; regulates growth, sporulation, and glycogen accumulation in a cAMP-dependent protein kinase cascade dependent manner; mutants are defective in 60S ribosome assembly; positively regulates pre-autophagosomal structure (PAS) formation upon nitrogen starvation or rapamycin treatment","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001465","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR026C"}


id: YIR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DAL1","product":"Allantoinase; converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression","secondary_identifier":"SGD:S000001466","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR027C"}


id: YIR028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02147":null,"SJAG_04714":null,"YIR028W":null},"has_protein_features":false,"name":"DAL4","ortholog_annotations":[{"gene_uniquename":"YIR028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02147","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YIR028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04714","reference_uniquename":"PMID:29761456"}],"product":"Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001467","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR028W"}


id: YIR029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00035":null,"YIR029W":null},"has_protein_features":false,"name":"DAL2","ortholog_annotations":[{"gene_uniquename":"YIR029W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00035","reference_uniquename":"PMID:29761456"}],"product":"Allantoicase; converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001468","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR029W"}


id: YIR030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00036":null,"SJAG_04298":null,"YIR030C":null},"has_protein_features":false,"name":"DCG1","ortholog_annotations":[{"gene_uniquename":"YIR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00036","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04298","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001469","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR030C"}


id: YIR030W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF DAL7/YIR031C","secondary_identifier":"SGD:S000028802","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR030W-A"}


id: YIR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DAL7","product":"Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation","secondary_identifier":"SGD:S000001470","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR031C"}


id: YIR032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05287":null,"YIR032C":null},"has_protein_features":false,"name":"DAL3","ortholog_annotations":[{"gene_uniquename":"YIR032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05287","reference_uniquename":"PMID:29761456"}],"product":"Ureidoglycolate lyase; converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression is sensitive to nitrogen catabolite repression; this enzyme is sometimes referred to 'ureidoglycolate hydrolase' but should not be confused with the Arabidopsis thaliana ureidoglycolate hydrolase enzyme which converts ureidoglycolate to glyoxylate, ammonia and carbon dioxide","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001471","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR032C"}


id: YIR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02196":null,"YIR033W":null},"has_protein_features":false,"name":"MGA2","ortholog_annotations":[{"gene_uniquename":"YIR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02196","reference_uniquename":"PMID:29761456"}],"product":"ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; MGA2 has a paralog, SPT23, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR033W"}


id: YIR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02388":null,"YIR034C":null},"has_protein_features":false,"name":"LYS1","ortholog_annotations":[{"gene_uniquename":"YIR034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02388","reference_uniquename":"PMID:29761456"}],"product":"Saccharopine dehydrogenase (NAD+, L-lysine-forming); catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001473","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR034C"}


id: YIR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03098":null,"YIR035C":null},"has_protein_features":false,"name":"NRE1","ortholog_annotations":[{"gene_uniquename":"YIR035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03098","reference_uniquename":"PMID:29761456"}],"product":"Putative cytoplasmic short-chain dehydrogenase/reductase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001474","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR035C"}


id: YIR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03098":null,"YIR036C":null},"has_protein_features":false,"name":"IRC24","ortholog_annotations":[{"gene_uniquename":"YIR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03098","reference_uniquename":"PMID:29761456"}],"product":"Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001475","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR036C"}


id: YIR036W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF IRC24/YIR036C","secondary_identifier":"SGD:S000028803","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR036W-A"}


id: YIR037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01216":null,"YIR037W":null},"has_protein_features":false,"name":"HYR1","ortholog_annotations":[{"gene_uniquename":"YIR037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01216","reference_uniquename":"PMID:29761456"}],"product":"Glutathione peroxidase; functions as hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce redox signal to Yap1p transcription factor; glutathione peroxidase activity is neuroprotective in models of Huntington's disease; HYR1 has a paralog, GPX1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001476","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR037W"}


id: YIR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05181":null,"YIR038C":null},"has_protein_features":false,"name":"GTT1","ortholog_annotations":[{"gene_uniquename":"YIR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05181","reference_uniquename":"PMID:29761456"}],"product":"ER associated glutathione S-transferase; capable of homodimerization; glutathione transferase for Yvc1p vacuolar cation channel; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001477","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR038C"}


id: YIR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00109":null,"SJAG_00254":null,"SJAG_00784":null,"SJAG_02260":null,"YIR039C":null},"has_protein_features":false,"name":"YPS6","ortholog_annotations":[{"gene_uniquename":"YIR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00109","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00254","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00784","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02260","reference_uniquename":"PMID:29761456"}],"product":"Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001478","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR039C"}


id: YIR040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001479","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR040C"}


id: YIR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU15","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole","secondary_identifier":"SGD:S000001480","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR041W"}


id: YIR042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YIR042C is a non-essential gene","secondary_identifier":"SGD:S000001481","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR042C"}


id: YIR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Blocked reading frame; may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family","secondary_identifier":"SGD:S000001482","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR043C"}


id: YJL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03151":null,"YJL001W":null},"has_protein_features":false,"name":"PRE3","ortholog_annotations":[{"gene_uniquename":"YJL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03151","reference_uniquename":"PMID:29761456"}],"product":"Beta 1 subunit of the 20S proteasome; responsible for cleavage after acidic residues in peptides","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003538","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL001W"}


id: YJL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01006":null,"YJL002C":null},"has_protein_features":false,"name":"OST1","ortholog_annotations":[{"gene_uniquename":"YJL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01006","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003539","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL002C"}


id: YJL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03296":null,"YJL003W":null},"has_protein_features":false,"name":"COX16","ortholog_annotations":[{"gene_uniquename":"YJL003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03296","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein; required for assembly of cytochrome c oxidase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003540","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL003W"}


id: YJL004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SYS1","product":"Integral membrane protein of the Golgi; required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation","secondary_identifier":"SGD:S000003541","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL004C"}


id: YJL005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01254":null,"YJL005W":null},"has_protein_features":false,"name":"CYR1","ortholog_annotations":[{"gene_uniquename":"YJL005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01254","reference_uniquename":"PMID:29761456"}],"product":"Adenylate cyclase; required for cAMP production and cAMP-dependent protein kinase signaling; scaffold protein for Ras2-Ira interaction; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003542","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL005W"}


id: YJL006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02057":null,"YJL006C":null},"has_protein_features":false,"name":"CTK2","ortholog_annotations":[{"gene_uniquename":"YJL006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02057","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of C-terminal domain kinase I (CTDK-I); which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003543","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL006C"}


id: YJL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000003544","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL007C"}


id: YJL008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00447":null,"YJL008C":null},"has_protein_features":false,"name":"CCT8","ortholog_annotations":[{"gene_uniquename":"YJL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00447","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003545","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL008C"}


id: YJL009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex","secondary_identifier":"SGD:S000003546","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL009W"}


id: YJL010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02250":null,"YJL010C":null},"has_protein_features":false,"name":"NOP9","ortholog_annotations":[{"gene_uniquename":"YJL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02250","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of U3-containing 90S preribosome; involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003547","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL010C"}


id: YJL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03035":null,"YJL011C":null},"has_protein_features":false,"name":"RPC17","ortholog_annotations":[{"gene_uniquename":"YJL011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03035","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003548","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL011C"}


id: YJL012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01080":null,"YJL012C":null},"has_protein_features":false,"name":"VTC4","ortholog_annotations":[{"gene_uniquename":"YJL012C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01080","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003549","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL012C"}


id: YJL012C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YJL012C-A was originally annotated as an independent ORF but due to a sequence change was merged with an adjacent ORF into a single reading frame, designated YJL012C/VTC4","secondary_identifier":"SGD:S000007609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL012C-A"}


id: YJL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04699":null,"YJL013C":null},"has_protein_features":false,"name":"MAD3","ortholog_annotations":[{"gene_uniquename":"YJL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04699","reference_uniquename":"PMID:29761456"}],"product":"Subunit of spindle-assembly checkpoint complex; involved in delaying anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover; MAD3 has a paralog, BUB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003550","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL013C"}


id: YJL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03570":null,"YJL014W":null},"has_protein_features":false,"name":"CCT3","ortholog_annotations":[{"gene_uniquename":"YJL014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03570","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; capable of binding Q/N rich proteins and mediating their folding","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003551","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL014W"}


id: YJL015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W","secondary_identifier":"SGD:S000003552","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL015C"}


id: YJL016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TPH3","product":"Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; contains two adjacent PH-like domains; conserved in closely related Saccharomyces species","secondary_identifier":"SGD:S000003553","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL016W"}


id: YJL017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YJL017W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YJL016W","secondary_identifier":"SGD:S000003554","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL017W"}


id: YJL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YJL018W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YJL019W","secondary_identifier":"SGD:S000003555","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL018W"}


id: YJL019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05196":null,"YJL019W":null},"has_protein_features":false,"name":"MPS3","ortholog_annotations":[{"gene_uniquename":"YJL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05196","reference_uniquename":"PMID:29761456"}],"product":"Nuclear envelope protein; required for SPB insertion, SPB duplication, Kar5p localization near the SPB and nuclear fusion; interacts with Mps2p to tether half-bridge to core SPB; N-terminal acetylation by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; member of the SUN protein family (Sad1-UNC-84 homology)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003556","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL019W"}


id: YJL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02202":null,"YJL020C":null},"has_protein_features":false,"name":"BBC1","ortholog_annotations":[{"gene_uniquename":"YJL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02202","reference_uniquename":"PMID:29761456"}],"product":"Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003557","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL020C"}


id: YJL020W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL020C/BBC1","secondary_identifier":"SGD:S000028659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL020W-A"}


id: YJL021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YJL021C was originally annotated as an independent ORF but due to a sequence change was merged with an adjacent ORF into a single reading frame, designated YJL020C/BBC1","secondary_identifier":"SGD:S000003558","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL021C"}


id: YJL022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130","secondary_identifier":"SGD:S000003559","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL022W"}


id: YJL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PET130","product":"Protein of unknown function; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; localizes to the matrix side of the inner mitochondrial membrane","secondary_identifier":"SGD:S000003560","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL023C"}


id: YJL024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03726":null,"YJL024C":null},"has_protein_features":false,"name":"APS3","ortholog_annotations":[{"gene_uniquename":"YJL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03726","reference_uniquename":"PMID:29761456"}],"product":"Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003561","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL024C"}


id: YJL025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02813":null,"YJL025W":null},"has_protein_features":false,"name":"RRN7","ortholog_annotations":[{"gene_uniquename":"YJL025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02813","reference_uniquename":"PMID:29761456"}],"product":"Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003562","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL025W"}


id: YJL026C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL026W/RNR2","secondary_identifier":"SGD:S000028660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL026C-A"}


id: YJL026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00885":null,"YJL026W":null},"has_protein_features":false,"name":"RNR2","ortholog_annotations":[{"gene_uniquename":"YJL026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00885","reference_uniquename":"PMID:29761456"}],"product":"Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; RNR2 has a paralog, RNR4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003563","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL026W"}


id: YJL027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000003564","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL027C"}


id: YJL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments","secondary_identifier":"SGD:S000003565","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL028W"}


id: YJL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04902":null,"YJL029C":null},"has_protein_features":false,"name":"VPS53","ortholog_annotations":[{"gene_uniquename":"YJL029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04902","reference_uniquename":"PMID:29761456"}],"product":"Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; required for vacuolar protein sorting; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p; human ortholog is implicated in progressive cerebello-cerebral atrophy type 2 (PCCA2)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL029C"}


id: YJL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01330":null,"YJL030W":null},"has_protein_features":false,"name":"MAD2","ortholog_annotations":[{"gene_uniquename":"YJL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01330","reference_uniquename":"PMID:29761456"}],"product":"Component of the spindle-assembly checkpoint complex; delays onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003567","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL030W"}


id: YJL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03810":null,"YJL031C":null},"has_protein_features":false,"name":"BET4","ortholog_annotations":[{"gene_uniquename":"YJL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03810","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003568","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL031C"}


id: YJL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase","secondary_identifier":"SGD:S000003569","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL032W"}


id: YJL033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02287":null,"YJL033W":null},"has_protein_features":false,"name":"HCA4","ortholog_annotations":[{"gene_uniquename":"YJL033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02287","reference_uniquename":"PMID:29761456"}],"product":"DEAD box RNA helicase; component of the SSU; interacts with Bfr2p and Enp2p; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003570","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL033W"}


id: YJL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00790":null,"YJL034W":null},"has_protein_features":false,"name":"KAR2","ortholog_annotations":[{"gene_uniquename":"YJL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00790","reference_uniquename":"PMID:29761456"}],"product":"ATPase involved in protein import into the ER; also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003571","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL034W"}


id: YJL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04189":null,"YJL035C":null},"has_protein_features":false,"name":"TAD2","ortholog_annotations":[{"gene_uniquename":"YJL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04189","reference_uniquename":"PMID:29761456"}],"product":"Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003572","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL035C"}


id: YJL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01135":null,"SJAG_01382":null,"YJL036W":null},"has_protein_features":false,"name":"SNX4","ortholog_annotations":[{"gene_uniquename":"YJL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01135","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01382","reference_uniquename":"PMID:29761456"}],"product":"Sorting nexin; involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003573","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL036W"}


id: YJL037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC18","product":"Protein involved in outer spore wall assembly; possible role in assembly of the dityrosine layer; similar to adjacent ORF, LOH1; irc18 loh1 double mutant exhibits reduced dityrosine fluorescence relative to single mutants; SWAT-GFP fusion protein localizes to the ER and vacuole, while mCherry fusion localizes to the vacuole; expression induced in respiratory-deficient cells and carbon-limited chemostat culture; null mutant displays increased levels of spontaneous Rad52p foci","secondary_identifier":"SGD:S000003574","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL037W"}


id: YJL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LOH1","product":"Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to adjacent ORF, IRC18/YJL037W, and the irc18 loh1 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants; SWAT-GFP and mCherry fusion proteins localize to the cytosol; proposed role in maintenance of genome integrity","secondary_identifier":"SGD:S000003575","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL038C"}


id: YJL039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03182":null,"YJL039C":null},"has_protein_features":false,"name":"NUP192","ortholog_annotations":[{"gene_uniquename":"YJL039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03182","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of inner ring of nuclear pore complex (NPC); plays a role in modulating transport through the NPC; homologous to human NUP205","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003576","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL039C"}


id: YJL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02274":null,"YJL041W":null},"has_protein_features":false,"name":"NSP1","ortholog_annotations":[{"gene_uniquename":"YJL041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02274","reference_uniquename":"PMID:29761456"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003577","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL041W"}


id: YJL042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MHP1","product":"Microtubule-associated protein involved in microtubule organization; involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins","secondary_identifier":"SGD:S000003578","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL042W"}


id: YJL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YJL043W is a non-essential gene","secondary_identifier":"SGD:S000003579","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL043W"}


id: YJL044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GYP6","product":"GTPase-activating protein (GAP) for yeast Rab family member Ypt6p; involved in vesicle mediated protein transport","secondary_identifier":"SGD:S000003580","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL044C"}


id: YJL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01671":null,"YJL045W":null},"has_protein_features":false,"name":"SDH9","ortholog_annotations":[{"gene_uniquename":"YJL045W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01671","reference_uniquename":"PMID:29761456"}],"product":"Minor succinate dehydrogenase isozyme; participates in oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner; YJL045W has a paralog, SDH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003581","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL045W"}


id: YJL046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01164":null,"YJL046W":null},"has_protein_features":false,"name":"AIM22","ortholog_annotations":[{"gene_uniquename":"YJL046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01164","reference_uniquename":"PMID:29761456"}],"product":"Lipoate-protein ligase; octanoyl-CoA: protein transferase required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003582","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL046W"}


id: YJL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RTT101","product":"Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; role in anaphase progression; Rtt101p-Mms22p ligase associates with replisome complex during S phase via Ctf4p; required for recovery after DSB repair; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p","secondary_identifier":"SGD:S000003583","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL047C"}


id: YJL047C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028804","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL047C-A"}


id: YJL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UBX6","product":"UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003584","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL048C"}


id: YJL049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05207":null,"YJL049W":null},"has_protein_features":false,"name":"CHM7","ortholog_annotations":[{"gene_uniquename":"YJL049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05207","reference_uniquename":"PMID:29761456"}],"product":"Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum presumably as part of an ESCRT-III like complex; null mutant has growth defect at 37 C in an apq12 deletion background; non-essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003585","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL049W"}


id: YJL050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_16455":null,"YJL050W":null},"has_protein_features":false,"name":"MTR4","ortholog_annotations":[{"gene_uniquename":"YJL050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16455","reference_uniquename":"PMID:29761456"}],"product":"RNA duplex-sensing translocase; ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003586","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL050W"}


id: YJL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC8","product":"Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc","secondary_identifier":"SGD:S000003587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL051W"}


id: YJL052C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified based on comparison to related yeast species; mCherry fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000007610","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL052C-A"}


id: YJL052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00027":null,"SJAG_02135":null,"SJAG_02945":null,"SJAG_03828":null,"SJAG_03903":null,"SJAG_06621":null,"SJAG_06622":null,"YJL052W":null},"has_protein_features":false,"name":"TDH1","ortholog_annotations":[{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00027","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02135","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02945","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03828","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03903","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06621","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06622","reference_uniquename":"PMID:29761456"}],"product":"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bateria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003588","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL052W"}


id: YJL053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00632":null,"YJL053W":null},"has_protein_features":false,"name":"PEP8","ortholog_annotations":[{"gene_uniquename":"YJL053W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00632","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003589","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL053W"}


id: YJL054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00404":null,"YJL054W":null},"has_protein_features":false,"name":"TIM54","ortholog_annotations":[{"gene_uniquename":"YJL054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00404","reference_uniquename":"PMID:29761456"}],"product":"Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003590","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL054W"}


id: YJL055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LOG1","product":"Putative protein of unknown function; functions together with HAM1 to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA, without affecting uptake or incorporation of uracil into RNA; proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA","secondary_identifier":"SGD:S000003591","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL055W"}


id: YJL056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ZAP1","product":"Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains","secondary_identifier":"SGD:S000003592","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL056C"}


id: YJL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IKS1","product":"Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p","secondary_identifier":"SGD:S000003593","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL057C"}


id: YJL058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01020":null,"SJAG_04987":null,"YJL058C":null},"has_protein_features":false,"name":"BIT61","ortholog_annotations":[{"gene_uniquename":"YJL058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01020","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04987","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003594","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL058C"}


id: YJL059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02716":null,"YJL059W":null},"has_protein_features":false,"name":"YHC3","ortholog_annotations":[{"gene_uniquename":"YJL059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02716","reference_uniquename":"PMID:29761456"}],"product":"Protein required for the ATP-dependent transport of arginine; vacuolar membrane protein; involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; human homolog CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003595","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL059W"}


id: YJL060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04988":null,"YJL060W":null},"has_protein_features":false,"name":"BNA3","ortholog_annotations":[{"gene_uniquename":"YJL060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04988","reference_uniquename":"PMID:29761456"}],"product":"Kynurenine aminotransferase; catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003596","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL060W"}


id: YJL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01065":null,"YJL061W":null},"has_protein_features":false,"name":"NUP82","ortholog_annotations":[{"gene_uniquename":"YJL061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01065","reference_uniquename":"PMID:29761456"}],"product":"Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p); relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003597","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL061W"}


id: YJL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02523":null,"YJL062W":null},"has_protein_features":false,"name":"LAS21","ortholog_annotations":[{"gene_uniquename":"YJL062W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02523","reference_uniquename":"PMID:29761456"}],"product":"Mannose-ethanolamine phosphotransferase; involved in biosynthesis of the glycosylphosphatidylinositol (GPI) core structure, catalyzing the addition of a side chain ethanolamine phosphate to the alpha1,6-linked second mannose residue of the GPI lipid precursor;  integral component of endoplasmic reticulum membrane; mutations affect cell wall integrity; homolog of human PIGG","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003598","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL062W"}


id: YJL062W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04348":null,"YJL062W-A":null},"has_protein_features":false,"name":"COA3","ortholog_annotations":[{"gene_uniquename":"YJL062W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04348","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for cytochrome c oxidase assembly; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; located in the mitochondrial inner membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007611","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL062W-A"}


id: YJL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01591":null,"YJL063C":null},"has_protein_features":false,"name":"MRPL8","ortholog_annotations":[{"gene_uniquename":"YJL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01591","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003599","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL063C"}


id: YJL064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1","secondary_identifier":"SGD:S000003600","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL064W"}


id: YJL065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DLS1","product":"Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003601","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL065C"}


id: YJL066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MPM1","product":"Mitochondrial intermembrane space protein of unknown function","secondary_identifier":"SGD:S000003602","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL066C"}


id: YJL067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003603","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL067W"}


id: YJL068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Esterase that can function as an S-formylglutathione hydrolase; non-essential intracellular esterase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D","secondary_identifier":"SGD:S000003604","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL068C"}


id: YJL069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00538":null,"YJL069C":null},"has_protein_features":false,"name":"UTP18","ortholog_annotations":[{"gene_uniquename":"YJL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00538","reference_uniquename":"PMID:29761456"}],"product":"Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; contains WD40 repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003605","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL069C"}


id: YJL070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003606","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL070C"}


id: YJL071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00695":null,"YJL071W":null},"has_protein_features":false,"name":"ARG2","ortholog_annotations":[{"gene_uniquename":"YJL071W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00695","reference_uniquename":"PMID:29761456"}],"product":"Acetylglutamate synthase (glutamate N-acetyltransferase); mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003607","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL071W"}


id: YJL072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00696":null,"YJL072C":null},"has_protein_features":false,"name":"PSF2","ortholog_annotations":[{"gene_uniquename":"YJL072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00696","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL072C"}


id: YJL073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"JEM1","product":"DnaJ-like chaperone required for nuclear membrane fusion during mating; localizes to the ER membrane; exhibits genetic interactions with KAR2","secondary_identifier":"SGD:S000003609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL073W"}


id: YJL074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05019":null,"YJL074C":null},"has_protein_features":false,"name":"SMC3","ortholog_annotations":[{"gene_uniquename":"YJL074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05019","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the multiprotein cohesin complex; required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003610","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL074C"}


id: YJL075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"APQ13","product":"Putative protein of unknown function; not conserved in closely related Saccharomyces species; 85% of ORF overlaps verified gene NET1, but does not share all phenotypes; null mutant is slow-growing, sensitive to heat, sorbate, and other various chemicals","secondary_identifier":"SGD:S000003611","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL075C"}


id: YJL076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00883":null,"YJL076W":null},"has_protein_features":false,"name":"NET1","ortholog_annotations":[{"gene_uniquename":"YJL076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00883","reference_uniquename":"PMID:29761456"}],"product":"Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003612","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL076W"}


id: YJL077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ICS3","product":"Protein with a role in copper homeostasis; possible role in vacuolar sorting and processing of secretory proteins; null mutants are hypersensitive to sortin2","secondary_identifier":"SGD:S000003613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL077C"}


id: YJL077W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data; completely overlaps the verified gene YJL077C/ICS3","secondary_identifier":"SGD:S000028661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL077W-A"}


id: YJL077W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL077W-B"}


id: YJL078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRY3","product":"GPI-anchored cell wall protein involved in export of sterols; redundant role with PRY1 and PRY2 in the export of free fatty acids; role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins)","secondary_identifier":"SGD:S000003614","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL078C"}


id: YJL079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRY1","product":"Lipid binding protein; binds to both free fatty acids with preference for saturated long-chain fatty acids and to sterols; contains two independent lipid-binding sites; involved in the export of free fatty acids and acetylated sterols; export functions are redundant with PRY2, and PRY3; important for survival of cells that accumulate free fatty acids; involved in detoxification  of hydrophobic compounds; secreted glycoprotein and member of the CAP/SCP protein superfamily","secondary_identifier":"SGD:S000003615","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL079C"}


id: YJL080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03696":null,"YJL080C":null},"has_protein_features":false,"name":"SCP160","ortholog_annotations":[{"gene_uniquename":"YJL080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03696","reference_uniquename":"PMID:29761456"}],"product":"Essential RNA-binding G protein effector of mating response pathway; ligand-activated RNA-binding protein that delivers RNAs involved in polarization and perpetualizing mating signal to shmoo tip during pheromone signaling; Scp160p-mediated RNA trafficking essential for chemotropism and successful mating; mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003616","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL080C"}


id: YJL081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01016":null,"SJAG_03058":null,"SJAG_03579":null,"YJL081C":null},"has_protein_features":false,"name":"ARP4","ortholog_annotations":[{"gene_uniquename":"YJL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01016","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03058","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03579","reference_uniquename":"PMID:29761456"}],"product":"Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003617","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL081C"}


id: YJL082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00219":null,"SJAG_00270":null,"YJL082W":null},"has_protein_features":false,"name":"IML2","ortholog_annotations":[{"gene_uniquename":"YJL082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00219","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00270","reference_uniquename":"PMID:29761456"}],"product":"Protein required for clearance of inclusion bodies; localizes to the inclusion bodies formed under protein misfolding stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003618","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL082W"}


id: YJL083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00724":null,"YJL083W":null},"has_protein_features":false,"name":"TAX4","ortholog_annotations":[{"gene_uniquename":"YJL083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00724","reference_uniquename":"PMID:29761456"}],"product":"EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL083W"}


id: YJL084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00032":null,"SJAG_03643":null,"YJL084C":null},"has_protein_features":false,"name":"ALY2","ortholog_annotations":[{"gene_uniquename":"YJL084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00032","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03643","reference_uniquename":"PMID:29761456"}],"product":"Alpha arrestin, Ub-ligase adaptor for Rsp5p; controls nutrient limitation-mediated endosomal recycling of the Gap1p amino acid permease; PY motif-containing adaptor involved in substrate-induced, Rsp5p-mediated ubiquitination and endocytosis of select plasma membrane localized amino acid transporters, such as Dip5p and Put4p; phosphorylated by Npr1p and by the Pcl7p-Pho85p cyclin-CDK complex; interacts with AP-1 subunit Apl4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003620","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL084C"}


id: YJL085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04960":null,"YJL085W":null},"has_protein_features":false,"name":"EXO70","ortholog_annotations":[{"gene_uniquename":"YJL085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04960","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003621","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL085W"}


id: YJL086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1","secondary_identifier":"SGD:S000003622","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL086C"}


id: YJL087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00956":null,"YJL087C":null},"has_protein_features":false,"name":"TRL1","ortholog_annotations":[{"gene_uniquename":"YJL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00956","reference_uniquename":"PMID:29761456"}],"product":"tRNA ligase; required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; involved in turnover of tRNA introns; localized at the inner nuclear envelope and cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003623","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL087C"}


id: YJL088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00635":null,"YJL088W":null},"has_protein_features":false,"name":"ARG3","ortholog_annotations":[{"gene_uniquename":"YJL088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00635","reference_uniquename":"PMID:29761456"}],"product":"Ornithine carbamoyltransferase; also known as carbamoylphosphate:L-ornithine carbamoyltransferase; catalyzes the biosynthesis of the arginine precursor citrulline","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003624","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL088W"}


id: YJL089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SIP4","product":"C6 zinc cluster transcriptional activator; binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus","secondary_identifier":"SGD:S000003625","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL089W"}


id: YJL090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02098":null,"YJL090C":null},"has_protein_features":false,"name":"DPB11","ortholog_annotations":[{"gene_uniquename":"YJL090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02098","reference_uniquename":"PMID:29761456"}],"product":"DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; along with Rfa1p, binds to ultrafine anaphase bridges in mitotic cells and prevents accumulation of chromatin bridges by stimulating the Mec1p kinase and suppressing homologous recombination; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL090C"}


id: YJL091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00068":null,"YJL091C":null},"has_protein_features":false,"name":"GWT1","ortholog_annotations":[{"gene_uniquename":"YJL091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00068","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in the inositol acylation of GlcN-PI; the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) forms glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL091C"}


id: YJL092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01221":null,"YJL092W":null},"has_protein_features":false,"name":"SRS2","ortholog_annotations":[{"gene_uniquename":"YJL092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01221","reference_uniquename":"PMID:29761456"}],"product":"DNA helicase and DNA-dependent ATPase; role in DNA repair and checkpoint recovery, in the proper timing of commitment to meiotic recombination and the Meiosis I to II transition; blocks trinucleotide repeat expansion; affects genome stability; disassembles Rad51p nucleoprotein filaments during meiotic recombination; stimulates Mus81p-Mms4p endonuclease activity independent of catalytic activity; ATPase and ssDNA translocating motor activities inhibited by Dmc1p; functional homolog of human RTEL1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL092W"}


id: YJL093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TOK1","product":"Outward-rectifier potassium channel of the plasma membrane; has two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin","secondary_identifier":"SGD:S000003629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL093C"}


id: YJL094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"KHA1","product":"Putative K+/H+ antiporter; involved in intracellular cation homeostasis; promotes copper binding to Fet3p multicopper oxidase; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000003630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL094C"}


id: YJL095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03753":null,"YJL095W":null},"has_protein_features":false,"name":"BCK1","ortholog_annotations":[{"gene_uniquename":"YJL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03753","reference_uniquename":"PMID:29761456"}],"product":"MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL095W"}


id: YJL096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01630":null,"YJL096W":null},"has_protein_features":false,"name":"MRPL49","ortholog_annotations":[{"gene_uniquename":"YJL096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01630","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL096W"}


id: YJL097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01300":null,"YJL097W":null},"has_protein_features":false,"name":"PHS1","ortholog_annotations":[{"gene_uniquename":"YJL097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01300","reference_uniquename":"PMID:29761456"}],"product":"Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane; involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003633","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL097W"}


id: YJL098W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04638":null,"YJL098W":null},"has_protein_features":false,"name":"SAP185","ortholog_annotations":[{"gene_uniquename":"YJL098W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04638","reference_uniquename":"PMID:29761456"}],"product":"Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003634","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL098W"}


id: YJL099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00916":null,"YJL099W":null},"has_protein_features":false,"name":"CHS6","ortholog_annotations":[{"gene_uniquename":"YJL099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00916","reference_uniquename":"PMID:29761456"}],"product":"Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; primary component of the Chs5/6 complex that binds directly to membranes; CHS6 has a paralog, BCH2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003635","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL099W"}


id: YJL100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01571":null,"YJL100W":null},"has_protein_features":false,"name":"LSB6","ortholog_annotations":[{"gene_uniquename":"YJL100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01571","reference_uniquename":"PMID:29761456"}],"product":"Type II phosphatidylinositol 4-kinase; binds Las17p, a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003636","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL100W"}


id: YJL101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00988":null,"YJL101C":null},"has_protein_features":false,"name":"GSH1","ortholog_annotations":[{"gene_uniquename":"YJL101C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00988","reference_uniquename":"PMID:29761456"}],"product":"Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003637","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL101C"}


id: YJL102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04862":null,"YJL102W":null},"has_protein_features":false,"name":"MEF2","ortholog_annotations":[{"gene_uniquename":"YJL102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04862","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial elongation factor involved in translational elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL102W"}


id: YJL103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GSM1","product":"Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis","secondary_identifier":"SGD:S000003639","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL103C"}


id: YJL104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00373":null,"YJL104W":null},"has_protein_features":false,"name":"PAM16","ortholog_annotations":[{"gene_uniquename":"YJL104W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00373","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the import motor (PAM complex); the PAM complex is a  component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003640","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL104W"}


id: YJL105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04396":null,"YJL105W":null},"has_protein_features":false,"name":"SET4","ortholog_annotations":[{"gene_uniquename":"YJL105W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04396","reference_uniquename":"PMID:29761456"}],"product":"Chromatin-associated protein involved in control of stress response; regulates response to oxidative stress; involved in control of gene repression in subtelomeric chromatin; contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003641","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL105W"}


id: YJL106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02712":null,"SJAG_03557":null,"YJL106W":null},"has_protein_features":false,"name":"IME2","ortholog_annotations":[{"gene_uniquename":"YJL106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02712","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03557","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase involved in activation of meiosis; associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p; human CDK2 can complement ime2 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL106W"}


id: YJL107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01770":null,"SJAG_04957":null,"YJL107C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJL107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01770","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04957","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL107C"}


id: YJL108C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01770":null,"SJAG_04957":null,"YJL108C":null},"has_protein_features":false,"name":"PRM10","ortholog_annotations":[{"gene_uniquename":"YJL108C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01770","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJL108C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04957","reference_uniquename":"PMID:26896847"}],"product":"Pheromone-regulated protein; proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000003644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL108C"}


id: YJL109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05187":null,"YJL109C":null},"has_protein_features":false,"name":"UTP10","ortholog_annotations":[{"gene_uniquename":"YJL109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05187","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL109C"}


id: YJL110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00792":null,"YJL110C":null},"has_protein_features":false,"name":"GZF3","ortholog_annotations":[{"gene_uniquename":"YJL110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00792","reference_uniquename":"PMID:29761456"}],"product":"GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL110C"}


id: YJL111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02926":null,"YJL111W":null},"has_protein_features":false,"name":"CCT7","ortholog_annotations":[{"gene_uniquename":"YJL111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02926","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL111W"}


id: YJL112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04732":null,"YJL112W":null},"has_protein_features":false,"name":"MDV1","ortholog_annotations":[{"gene_uniquename":"YJL112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04732","reference_uniquename":"PMID:29761456"}],"product":"Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the self-assembled oligomeric form of the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003648","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL112W"}


id: YJL115W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03366":null,"YJL115W":null},"has_protein_features":false,"name":"ASF1","ortholog_annotations":[{"gene_uniquename":"YJL115W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03366","reference_uniquename":"PMID:29761456"}],"product":"Nucleosome assembly factor; involved in chromatin assembly, disassembly; required for recovery after DSB repair; role in H3K56 acetylation required for expression homeostasis, buffering mRNA synthesis rate against gene dosage changes in S phase; anti-silencing protein, derepresses silent loci when overexpressed; role in regulating Ty1 transposition; relocalizes to cytosol under hypoxia; growth defect of asf1 null is functionally complemented by either human ASF1A or ASF1B","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL115W"}


id: YJL116C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02649":null,"SJAG_03295":null,"YJL116C":null},"has_protein_features":false,"name":"NCA3","ortholog_annotations":[{"gene_uniquename":"YJL116C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02649","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL116C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03295","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the vacuole; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL116C"}


id: YJL117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01899":null,"YJL117W":null},"has_protein_features":false,"name":"PHO86","ortholog_annotations":[{"gene_uniquename":"YJL117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01899","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003653","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL117W"}


id: YJL118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL118W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein","secondary_identifier":"SGD:S000003654","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL118W"}


id: YJL119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL119C"}


id: YJL120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO","secondary_identifier":"SGD:S000003656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL120W"}


id: YJL121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00501":null,"YJL121C":null},"has_protein_features":false,"name":"RPE1","ortholog_annotations":[{"gene_uniquename":"YJL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00501","reference_uniquename":"PMID:29761456"}],"product":"D-ribulose-5-phosphate 3-epimerase; catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL121C"}


id: YJL122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00932":null,"YJL122W":null},"has_protein_features":false,"name":"ALB1","ortholog_annotations":[{"gene_uniquename":"YJL122W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00932","reference_uniquename":"PMID:29761456"}],"product":"Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL122W"}


id: YJL123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01085":null,"YJL123C":null},"has_protein_features":false,"name":"MTC1","ortholog_annotations":[{"gene_uniquename":"YJL123C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01085","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL123C"}


id: YJL124C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04880":null,"YJL124C":null},"has_protein_features":false,"name":"LSM1","ortholog_annotations":[{"gene_uniquename":"YJL124C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04880","reference_uniquename":"PMID:29761456"}],"product":"Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; also enters the nucleus and positively regulates transcription initiation; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; binds to mRNAs under glucose starvation, most often in the 3' UTR; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL124C"}


id: YJL125C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02386":null,"YJL125C":null},"has_protein_features":false,"name":"GCD14","ortholog_annotations":[{"gene_uniquename":"YJL125C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02386","reference_uniquename":"PMID:29761456"}],"product":"Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL125C"}


id: YJL126W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04939":null,"YJL126W":null},"has_protein_features":false,"name":"NIT2","ortholog_annotations":[{"gene_uniquename":"YJL126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04939","reference_uniquename":"PMID:29761456"}],"product":"Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL126W"}


id: YJL127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPT10","product":"Histone H3 acetylase with a role in transcriptional regulation; sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near TATA box; involved in S phase-specific acetylation of H3K56 at histone promoters, which is required for recruitment of SWI/SNF nucleosome remodeling complex and subsequent transcription","secondary_identifier":"SGD:S000003663","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL127C"}


id: YJL127C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05268":null,"YJL127C-B":null},"has_protein_features":false,"name":"MCO6","ortholog_annotations":[{"gene_uniquename":"YJL127C-B","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05268","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein of unknown function; identified based on homology to the filamentous fungus, <i>Ashbya gossypii</i>; SWAT-GFP and seamless-GFP fusion proteins localize to the mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL127C-B"}


id: YJL127W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007612","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL127W-A"}


id: YJL128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02342":null,"YJL128C":null},"has_protein_features":false,"name":"PBS2","ortholog_annotations":[{"gene_uniquename":"YJL128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02342","reference_uniquename":"PMID:29761456"}],"product":"MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003664","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL128C"}


id: YJL129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01353":null,"SJAG_02883":null,"YJL129C":null},"has_protein_features":false,"name":"TRK1","ortholog_annotations":[{"gene_uniquename":"YJL129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01353","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02883","reference_uniquename":"PMID:29761456"}],"product":"Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003665","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL129C"}


id: YJL130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00964":null,"YJL130C":null},"has_protein_features":false,"name":"URA2","ortholog_annotations":[{"gene_uniquename":"YJL130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00964","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003666","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL130C"}


id: YJL131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04635":null,"YJL131C":null},"has_protein_features":false,"name":"AIM23","ortholog_annotations":[{"gene_uniquename":"YJL131C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04635","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; interacts with mitochondrial ribosomal small subunit; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003667","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL131C"}


id: YJL132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene","secondary_identifier":"SGD:S000003668","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL132W"}


id: YJL133C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DPI8","product":"Putative mitochondrial protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000028805","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL133C-A"}


id: YJL133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02473":null,"SJAG_04737":null,"YJL133W":null},"has_protein_features":false,"name":"MRS3","ortholog_annotations":[{"gene_uniquename":"YJL133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02473","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04737","reference_uniquename":"PMID:29761456"}],"product":"Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL133W"}


id: YJL134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04986":null,"YJL134W":null},"has_protein_features":false,"name":"LCB3","ortholog_annotations":[{"gene_uniquename":"YJL134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04986","reference_uniquename":"PMID:29761456"}],"product":"Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003670","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL134W"}


id: YJL135W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3","secondary_identifier":"SGD:S000003671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL135W"}


id: YJL136C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04174":null,"YJL136C":null},"has_protein_features":false,"name":"RPS21B","ortholog_annotations":[{"gene_uniquename":"YJL136C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04174","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL136C"}


id: YJL136W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by SAGE","secondary_identifier":"SGD:S000028806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL136W-A"}


id: YJL137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GLG2","product":"Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL137C"}


id: YJL138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04772":null,"YJL138C":null},"has_protein_features":false,"name":"TIF2","ortholog_annotations":[{"gene_uniquename":"YJL138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04772","reference_uniquename":"PMID:29761456"}],"product":"Translation initiation factor eIF4A; DEAD-box RNA helicase that couples ATPase activity to mRNA binding and unwinding; ATP hydrolysis accelerates the recruitment of mRNA during 48S preinitiation complex (PIC) assembly; ATPase activity stimulated by either eIF4G1 or by the PIC in an eIF3g and eIFGi subunit-dependent manner, independent of eIF4E and eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E and eIF4G; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003674","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL138C"}


id: YJL139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"YJL139C":null},"has_protein_features":false,"name":"YUR1","ortholog_annotations":[{"gene_uniquename":"YJL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"}],"product":"Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003675","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL139C"}


id: YJL140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00458":null,"YJL140W":null},"has_protein_features":false,"name":"RPB4","ortholog_annotations":[{"gene_uniquename":"YJL140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00458","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL140W"}


id: YJL141C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02392":null,"SJAG_03887":null,"SJAG_04980":null,"YJL141C":null},"has_protein_features":false,"name":"YAK1","ortholog_annotations":[{"gene_uniquename":"YJL141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02392","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03887","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04980","reference_uniquename":"PMID:29761456"}],"product":"Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL141C"}


id: YJL142C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC9","product":"Putative protein of unknown function; partially overlaps verified gene YAK1/YJL141C but does not share all phenotypes; null mutant displays increased levels of spontaneous Rad52p foci, increased sporulation efficiency, and small defect in vacuolar fragmentation","secondary_identifier":"SGD:S000003678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL142C"}


id: YJL143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01879":null,"YJL143W":null},"has_protein_features":false,"name":"TIM17","ortholog_annotations":[{"gene_uniquename":"YJL143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01879","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the TIM23 complex; with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core Translocase of the Inner Mitochondrial membrane (TIM23 complex)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003679","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL143W"}


id: YJL144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ROQ1","product":"Ub-ligase substrate-specificity factor; proteolytically-cleaved form acts as a pseudosubstrate, binding and altering the substrate specificity of Ubr1p towards misfolded and native ER membrane and cytosolic proteins, as part of the stress-induced homeostatically regulated protein degradation (SHRED) pathway; hydrophilin essential during desiccation-rehydration; induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003680","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL144W"}


id: YJL145W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SFH5","product":"Unusual phosphatidylinositol transfer protein (PITP) that binds heme; similar to Sec14p; founding member of conserved class of fungal hemoproteins; exhibits PI- but not PC-transfer activity; localizes to peripheral endoplasmic reticulum, cytosol, and microsomes; partially relocalizes to plasma membrane upon DNA replication stress","secondary_identifier":"SGD:S000003681","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL145W"}


id: YJL146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IDS2","product":"Protein involved in modulation of Ime2p activity during meiosis; appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation","secondary_identifier":"SGD:S000003682","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL146W"}


id: YJL147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SMT1","product":"Translational repressor of the mitochondrial ATP6/8 mRNA; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage","secondary_identifier":"SGD:S000003683","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL147C"}


id: YJL148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03468":null,"YJL148W":null},"has_protein_features":false,"name":"RPA34","ortholog_annotations":[{"gene_uniquename":"YJL148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03468","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase I subunit A34.5; essential for nucleolar assembly and for high polymerase loading rate; nucleolar localization depends on Rpa49p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL148W"}


id: YJL149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DAS1","product":"Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C","secondary_identifier":"SGD:S000003685","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL149W"}


id: YJL150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003686","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL150W"}


id: YJL151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00372":null,"YJL151C":null},"has_protein_features":false,"name":"SNA3","ortholog_annotations":[{"gene_uniquename":"YJL151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00372","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003687","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL151C"}


id: YJL152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003688","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL152W"}


id: YJL153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"INO1","product":"Inositol-3-phosphate synthase; involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element","secondary_identifier":"SGD:S000003689","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL153C"}


id: YJL154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01039":null,"YJL154C":null},"has_protein_features":false,"name":"VPS35","ortholog_annotations":[{"gene_uniquename":"YJL154C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01039","reference_uniquename":"PMID:29761456"}],"product":"Endosomal subunit of membrane-associated retromer complex; required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p; overexpression of wild-type human VPS35 or Parkinson's-associated vps35-D686N or vps35-P299S variants complements Ni2+ resistance and Cd2+ sensitivity of yeast vps35 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003690","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL154C"}


id: YJL155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02713":null,"YJL155C":null},"has_protein_features":false,"name":"FBP26","ortholog_annotations":[{"gene_uniquename":"YJL155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02713","reference_uniquename":"PMID:29761456"}],"product":"Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003691","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL155C"}


id: YJL156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SSY5","product":"Serine protease of SPS plasma membrane amino acid sensor system; contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p; other members are Ssy1p and Ptr3p","secondary_identifier":"SGD:S000003692","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL156C"}


id: YJL156W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL156W-A"}


id: YJL157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FAR1","product":"CDK inhibitor and nuclear anchor; during the cell cycle Far1p sequesters the GEF Cdc24p in the nucleus; phosphorylation by Cdc28p-Cln results in SCFCdc4 complex-mediated ubiquitin-dependent degradation, releasing Cdc24p for export and activation of GTPase Cdc42p; in response to pheromone, phosphorylation of Far1p by MAPK Fus3p results in association with, and inhibition of Cdc28p-Cln, as well as Msn5p mediated nuclear export of Far1p-Cdc24p, targeting Cdc24p to polarity sites","secondary_identifier":"SGD:S000003693","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL157C"}


id: YJL158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CIS3","product":"Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family","secondary_identifier":"SGD:S000003694","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL158C"}


id: YJL159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HSP150","product":"O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003695","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL159W"}


id: YJL160C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PIR5","product":"Putative protein of unknown function; member of the PIR (Proteins with Internal Repeats) family of cell wall proteins; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, and mCherry fusion localizes to the vacuole; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003696","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL160C"}


id: YJL161W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMP33","product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000003697","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL161W"}


id: YJL162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02518":null,"SJAG_03052":null,"YJL162C":null},"has_protein_features":false,"name":"JJJ2","ortholog_annotations":[{"gene_uniquename":"YJL162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02518","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03052","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; contains a J-domain, which is a region with homology to the E. coli DnaJ protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003698","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL162C"}


id: YJL163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03447":null,"YJL163C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJL163C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03447","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003699","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL163C"}


id: YJL164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04312":null,"YJL164C":null},"has_protein_features":false,"name":"TPK1","ortholog_annotations":[{"gene_uniquename":"YJL164C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04312","reference_uniquename":"PMID:29761456"}],"product":"cAMP-dependent protein kinase catalytic subunit; role in nutrient-stimulated growth via Ras-cAMP signaling; inhibited by regulatory subunit Bcy1p in cAMPs absence; phosphorylates and inhibits Whi3p to promote G1/S phase passage; phosphorylates Nej1p to regulate nonhomologous end joining (NHEJ); impairs mitochondrial import of pre-Tom40p via phosphorylation under non-respiratory conditions; partially redundant with Tpk2p and Tpk3p; human homolog PRKACB regulates NHEJ via NHEJ1 phosphorylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003700","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL164C"}


id: YJL165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HAL5","product":"Snf1p-related nutrient-responsive protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003701","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL165C"}


id: YJL166W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00080":null,"YJL166W":null},"has_protein_features":false,"name":"QCR8","ortholog_annotations":[{"gene_uniquename":"YJL166W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00080","reference_uniquename":"PMID:29761456"}],"product":"Subunit 8 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003702","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL166W"}


id: YJL167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00580":null,"SJAG_03352":null,"YJL167W":null},"has_protein_features":false,"name":"ERG20","ortholog_annotations":[{"gene_uniquename":"YJL167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00580","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03352","reference_uniquename":"PMID:29761456"}],"product":"Farnesyl pyrophosphate synthetase; has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003703","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL167W"}


id: YJL168C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02873":null,"YJL168C":null},"has_protein_features":false,"name":"SET2","ortholog_annotations":[{"gene_uniquename":"YJL168C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02873","reference_uniquename":"PMID:29761456"}],"product":"Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain(CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL168C"}


id: YJL169W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2","secondary_identifier":"SGD:S000003705","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL169W"}


id: YJL170C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ASG7","product":"Protein that regulates signaling from G protein beta subunit Ste4p; contributes to relocalization of Ste4p within the cell; specific to a-cells and induced by alpha-factor","secondary_identifier":"SGD:S000003706","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL170C"}


id: YJL171C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00876":null,"YJL171C":null},"has_protein_features":false,"name":"TOH1","ortholog_annotations":[{"gene_uniquename":"YJL171C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00876","reference_uniquename":"PMID:29761456"}],"product":"GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003707","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL171C"}


id: YJL172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03586":null,"YJL172W":null},"has_protein_features":false,"name":"CPS1","ortholog_annotations":[{"gene_uniquename":"YJL172W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03586","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar carboxypeptidase S; expression is induced under low-nitrogen conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003708","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL172W"}


id: YJL173C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03722":null,"YJL173C":null},"has_protein_features":false,"name":"RFA3","ortholog_annotations":[{"gene_uniquename":"YJL173C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03722","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003709","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL173C"}


id: YJL174W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04073":null,"YJL174W":null},"has_protein_features":false,"name":"KRE9","ortholog_annotations":[{"gene_uniquename":"YJL174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04073","reference_uniquename":"PMID:29761456"}],"product":"Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003710","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL174W"}


id: YJL175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor","secondary_identifier":"SGD:S000003711","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL175W"}


id: YJL176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02447":null,"SJAG_02589":null,"YJL176C":null},"has_protein_features":false,"name":"SWI3","ortholog_annotations":[{"gene_uniquename":"YJL176C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02447","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL176C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02589","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; contains SANT domain that is required for SWI/SNF assembly; is essential for displacement of histone H2A-H2B dimers during ATP-dependent remodeling; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003712","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL176C"}


id: YJL177W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00940":null,"SJAG_01721":null,"YJL177W":null},"has_protein_features":false,"name":"RPL17B","ortholog_annotations":[{"gene_uniquename":"YJL177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00940","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01721","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L17B; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003713","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL177W"}


id: YJL178C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG27","product":"Type I membrane protein involved in autophagy and the Cvt pathway; may be involved in membrane delivery to the phagophore assembly site","secondary_identifier":"SGD:S000003714","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL178C"}


id: YJL179W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03463":null,"YJL179W":null},"has_protein_features":false,"name":"PFD1","ortholog_annotations":[{"gene_uniquename":"YJL179W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03463","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heterohexameric prefoldin; prefoldin binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003715","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL179W"}


id: YJL180C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01503":null,"YJL180C":null},"has_protein_features":false,"name":"ATP12","ortholog_annotations":[{"gene_uniquename":"YJL180C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01503","reference_uniquename":"PMID:29761456"}],"product":"Assembly factor for F1 sector of mitochondrial F1F0 ATP synthase; conserved protein; required for assembly of alpha and beta subunits into F1 sector of mitochondrial F1F0 ATP synthase; human homolog ATPAF2 can complement yeast atp12 mutant; mutation of human homolog reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003716","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL180C"}


id: YJL181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RBH1","product":"Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; contains a PH-like domain; RBH1 has a paralog, RBH2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003717","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL181W"}


id: YJL182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W","secondary_identifier":"SGD:S000003718","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL182C"}


id: YJL183W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01972":null,"SJAG_02996":null,"SJAG_03555":null,"SJAG_03790":null,"SJAG_03871":null,"SJAG_04095":null,"SJAG_04401":null,"YJL183W":null},"has_protein_features":false,"name":"MNN11","ortholog_annotations":[{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01972","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02996","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03555","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03790","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03871","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04095","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04401","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a Golgi mannosyltransferase complex; this complex also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003719","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL183W"}


id: YJL184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06560":null,"YJL184W":null},"has_protein_features":false,"name":"GON7","ortholog_annotations":[{"gene_uniquename":"YJL184W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06560","reference_uniquename":"PMID:29761456"}],"product":"Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; implicated in osmotic stress response; other complex members are Kae1p, Cgi121p, Pcc1p, and Bud32p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003720","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL184W"}


id: YJL185C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG36","product":"Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene","secondary_identifier":"SGD:S000003721","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL185C"}


id: YJL186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MNN5","product":"Alpha-1,2-mannosyltransferase; responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment","secondary_identifier":"SGD:S000003722","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL186W"}


id: YJL187C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03854":null,"SJAG_04280":null,"YJL187C":null},"has_protein_features":false,"name":"SWE1","ortholog_annotations":[{"gene_uniquename":"YJL187C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03854","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL187C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04280","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase that regulates the G2/M transition; negative regulator of the Cdc28p kinase; morphogenesis checkpoint kinase; positive regulator of sphingolipid biosynthesis via Orm2p; phosphorylates a tyrosine residue in the N-terminus of Hsp90 in a cell-cycle associated manner, thus modulating the ability of Hsp90 to chaperone a selected clientele; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003723","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL187C"}


id: YJL188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUD19","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay","secondary_identifier":"SGD:S000003724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL188C"}


id: YJL189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03364":null,"YJL189W":null},"has_protein_features":false,"name":"RPL39","ortholog_annotations":[{"gene_uniquename":"YJL189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03364","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003725","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL189W"}


id: YJL190C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01512":null,"SJAG_03762":null,"YJL190C":null},"has_protein_features":false,"name":"RPS22A","ortholog_annotations":[{"gene_uniquename":"YJL190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01512","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03762","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003726","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL190C"}


id: YJL191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01548":null,"SJAG_03424":null,"YJL191W":null},"has_protein_features":false,"name":"RPS14B","ortholog_annotations":[{"gene_uniquename":"YJL191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01548","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03424","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003727","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL191W"}


id: YJL192C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00277":null,"YJL192C":null},"has_protein_features":false,"name":"SOP4","ortholog_annotations":[{"gene_uniquename":"YJL192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00277","reference_uniquename":"PMID:29761456"}],"product":"ER-membrane protein; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5 of TOM (Translocase of the Mitochondrial Outer Membrane) complex; suppressor of pma1-7, deletion of SOP4 slows down export of wild-type Pma1p and Pma1-7 from the ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003728","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL192C"}


id: YJL193W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00276":null,"YJL193W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJL193W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00276","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003729","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL193W"}


id: YJL194W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02074":null,"YJL194W":null},"has_protein_features":false,"name":"CDC6","ortholog_annotations":[{"gene_uniquename":"YJL194W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02074","reference_uniquename":"PMID:29761456"}],"product":"Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress; degraded in response to plasma membrane stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003730","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL194W"}


id: YJL195C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6","secondary_identifier":"SGD:S000003731","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL195C"}


id: YJL196C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01356":null,"SJAG_02885":null,"YJL196C":null},"has_protein_features":false,"name":"ELO1","ortholog_annotations":[{"gene_uniquename":"YJL196C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01356","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL196C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02885","reference_uniquename":"PMID:29761456"}],"product":"Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, ELO2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003732","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL196C"}


id: YJL197C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL197C/UBP12","secondary_identifier":"SGD:S000028839","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL197C-A"}


id: YJL197W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04215":null,"SJAG_04651":null,"YJL197W":null},"has_protein_features":false,"name":"UBP12","ortholog_annotations":[{"gene_uniquename":"YJL197W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04215","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL197W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04651","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003733","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL197W"}


id: YJL198W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01059":null,"YJL198W":null},"has_protein_features":false,"name":"PHO90","ortholog_annotations":[{"gene_uniquename":"YJL198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01059","reference_uniquename":"PMID:29761456"}],"product":"Low-affinity phosphate transporter; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003734","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL198W"}


id: YJL199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MBB1","product":"Protein of unknown function; conserved among S. cerevisiae strains, not conserved in closely related Saccharomyces species; protein detected via large-scale protein-protein interaction studies and enrichment-based proteogenomics; YJL199C is not an essential gene","secondary_identifier":"SGD:S000003735","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL199C"}


id: YJL200C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01630":null,"YJL200C":null},"has_protein_features":false,"name":"ACO2","ortholog_annotations":[{"gene_uniquename":"YJL200C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01630","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003736","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL200C"}


id: YJL201W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM25","product":"Endocytic site protein required for stress-induced cell elongation; may link the polarization signal with the endocytic machinery to facilitate adaptive morphogenesis under conditions of stress; interacts with the polarity regulator Cdc42p, the SH3 domains of actin patch components and actin filaments; contains a Rho-GAP domain lacking the catalytic arginine finger, PXXP motifs and an xACT (F-actin binding) motif; promoter contains a consensus binding sequence for transcription factor Abf1p","secondary_identifier":"SGD:S000003737","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL201W"}


id: YJL202C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex","secondary_identifier":"SGD:S000003738","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL202C"}


id: YJL203W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04318":null,"YJL203W":null},"has_protein_features":false,"name":"PRP21","ortholog_annotations":[{"gene_uniquename":"YJL203W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04318","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SF3a splicing factor complex; required for spliceosome assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003739","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL203W"}


id: YJL204C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02753":null,"YJL204C":null},"has_protein_features":false,"name":"RCY1","ortholog_annotations":[{"gene_uniquename":"YJL204C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02753","reference_uniquename":"PMID:29761456"}],"product":"F-box protein involved in recycling endocytosed proteins; involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth; direct interaction with C-terminal cytoplasmic region of Drs2p plays an important role for Drs2p function in endocytic recycling pathway; required for turnover of histone H3 variant Cse4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003740","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL204C"}


id: YJL205C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07004":null,"YJL205C":null},"has_protein_features":false,"name":"NCE101","ortholog_annotations":[{"gene_uniquename":"YJL205C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07004","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; involved in secretion of proteins that lack classical secretory signal sequences; SWAT-GFP and mCherry fusion proteins localize to the cytosol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003742","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL205C"}


