# genes

id: YDL201W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04680":null,"YDL201W":null},"has_protein_features":false,"name":"TRM8","ortholog_annotations":[{"gene_uniquename":"YDL201W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04680","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002360","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL201W"}


id: YDL202W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04889":null,"YDL202W":null},"has_protein_features":false,"name":"MRPL11","ortholog_annotations":[{"gene_uniquename":"YDL202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04889","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002361","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL202W"}


id: YDL203C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02733":null,"SJAG_04595":null,"YDL203C":null},"has_protein_features":false,"name":"ACK1","ortholog_annotations":[{"gene_uniquename":"YDL203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02733","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04595","reference_uniquename":"PMID:29761456"}],"product":"Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002362","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL203C"}


id: YDL204W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01848":null,"YDL204W":null},"has_protein_features":false,"name":"RTN2","ortholog_annotations":[{"gene_uniquename":"YDL204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01848","reference_uniquename":"PMID:29761456"}],"product":"Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; interacts with Sec6p, Yip3p, and Sbh1p; less abundant than RTN1; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002363","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL204W"}


id: YDL205C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02896":null,"YDL205C":null},"has_protein_features":false,"name":"HEM3","ortholog_annotations":[{"gene_uniquename":"YDL205C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02896","reference_uniquename":"PMID:29761456"}],"product":"Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme; human homolog HMBS can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002364","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL205C"}


id: YDL206W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04892":null,"YDL206W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDL206W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04892","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; YDL206W is not an essential protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002365","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL206W"}


id: YDL207W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03847":null,"YDL207W":null},"has_protein_features":false,"name":"GLE1","ortholog_annotations":[{"gene_uniquename":"YDL207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03847","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic nucleoporin required for polyadenylated mRNA export; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export; mediates translation initiation; required for efficient translation termination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002366","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL207W"}


id: YDL208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00083":null,"YDL208W":null},"has_protein_features":false,"name":"NHP2","ortholog_annotations":[{"gene_uniquename":"YDL208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00083","reference_uniquename":"PMID:29761456"}],"product":"Protein related to mammalian high mobility group (HMG) proteins; nuclear protein; essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002367","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL208W"}


id: YDL209C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04898":null,"YDL209C":null},"has_protein_features":false,"name":"CWC2","ortholog_annotations":[{"gene_uniquename":"YDL209C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04898","reference_uniquename":"PMID:29761456"}],"product":"Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002368","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL209C"}


id: YDL210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00015":null,"SJAG_00019":null,"SJAG_01096":null,"SJAG_02062":null,"SJAG_02113":null,"SJAG_02133":null,"SJAG_02144":null,"SJAG_02941":null,"SJAG_04135":null,"SJAG_04673":null,"SJAG_06598":null,"YDL210W":null},"has_protein_features":false,"name":"UGA4","ortholog_annotations":[{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00015","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00019","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01096","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02062","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02113","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02133","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02144","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02941","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04135","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04673","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06598","reference_uniquename":"PMID:29761456"}],"product":"GABA (gamma-aminobutyrate) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002369","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL210W"}


id: YDL211C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YDL211C has a paralog, TDA7, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002370","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL211C"}


id: YDL212W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04684":null,"YDL212W":null},"has_protein_features":false,"name":"SHR3","ortholog_annotations":[{"gene_uniquename":"YDL212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04684","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum packaging chaperone; required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002371","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL212W"}


id: YDL213C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01201":null,"YDL213C":null},"has_protein_features":false,"name":"NOP6","ortholog_annotations":[{"gene_uniquename":"YDL213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01201","reference_uniquename":"PMID:29761456"}],"product":"rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002372","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL213C"}


id: YDL214C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00963":null,"SJAG_04268":null,"YDL214C":null},"has_protein_features":false,"name":"PRR2","ortholog_annotations":[{"gene_uniquename":"YDL214C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00963","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL214C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04268","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase; inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance; PRR2 has a paralog, NPR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002373","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL214C"}


id: YDL215C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GDH2","product":"NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis","secondary_identifier":"SGD:S000002374","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL215C"}


id: YDL216C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00720":null,"YDL216C":null},"has_protein_features":false,"name":"RRI1","ortholog_annotations":[{"gene_uniquename":"YDL216C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00720","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of the COP9 signalosome (CSN) complex; acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling; involved in modulation of genes controlling amino acid and lipid metabolism, and ergosterol biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002375","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL216C"}


id: YDL217C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01640":null,"YDL217C":null},"has_protein_features":false,"name":"TIM22","ortholog_annotations":[{"gene_uniquename":"YDL217C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01640","reference_uniquename":"PMID:29761456"}],"product":"Essential core component of mitochondrial TIM22 complex; involved in insertion of polytopic proteins into inner membrane; forms channel through which proteins are imported; different regions of Tim22p have functionally diverse roles in recruiting partner subunits to core channel","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002376","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL217C"}


id: YDL218W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin","secondary_identifier":"SGD:S000002377","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL218W"}


id: YDL219W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01248":null,"YDL219W":null},"has_protein_features":false,"name":"DTD1","ortholog_annotations":[{"gene_uniquename":"YDL219W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01248","reference_uniquename":"PMID:29761456"}],"product":"D-Tyr-tRNA(Tyr) deacylase; functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL219W"}


id: YDL220C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02194":null,"YDL220C":null},"has_protein_features":false,"name":"CDC13","ortholog_annotations":[{"gene_uniquename":"YDL220C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02194","reference_uniquename":"PMID:29761456"}],"product":"Single stranded DNA-binding protein found at TG1-3 telomere G-tails; key roles in regulation of telomerase, telomere end protection, conventional telomere replication; regulates telomere replication through recruitment of specific sub-complexes, essential function is telomere capping; forms homodimer via N-terminus; disruption of dimerization leads to short telomeres; autophagy and proteasome are involved in Cdc13p degradation; differentially phosphorylated through cell cycle","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL220C"}


id: YDL221W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13","secondary_identifier":"SGD:S000002380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL221W"}


id: YDL222C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMP45","product":"Integral membrane protein localized to mitochondria; required for sporulation and maintaining sphingolipid content; similar to SUR7; FMP45 has a paralog, YNL194C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL222C"}


id: YDL223C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HBT1","product":"Shmoo tip protein, substrate of Hub1p ubiquitin-like protein; mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis; HBT1 has a paralog, YNL195C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL223C"}


id: YDL224C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01843":null,"SJAG_02554":null,"YDL224C":null},"has_protein_features":false,"name":"WHI4","ortholog_annotations":[{"gene_uniquename":"YDL224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01843","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02554","reference_uniquename":"PMID:29761456"}],"product":"Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002383","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL224C"}


id: YDL225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01769":null,"YDL225W":null},"has_protein_features":false,"name":"SHS1","ortholog_annotations":[{"gene_uniquename":"YDL225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01769","reference_uniquename":"PMID:26896847"}],"product":"Component of the septin ring that is required for cytokinesis; present at the ends of rod-like septin hetero-oligomers; C-terminal extension is important for recruitment of Bni5p to the mother-bud neck, which in turn is required for Myo1p recruitment and cytokinesis; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000002384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL225W"}


id: YDL226C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03268":null,"YDL226C":null},"has_protein_features":false,"name":"GCS1","ortholog_annotations":[{"gene_uniquename":"YDL226C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03268","reference_uniquename":"PMID:29761456"}],"product":"ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; required for prospore membrane formation; regulates phospholipase Spo14p; shares functional similarity with Glo3p; GCS1 has a paralog, SPS18, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL226C"}


id: YDL227C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HO","product":"Site-specific endonuclease; required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p, and Ash1p","secondary_identifier":"SGD:S000002386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL227C"}


id: YDL228C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene SSB1","secondary_identifier":"SGD:S000002387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL228C"}


id: YDL229W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03237":null,"YDL229W":null},"has_protein_features":false,"name":"SSB1","ortholog_annotations":[{"gene_uniquename":"YDL229W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03237","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL229W"}


id: YDL230W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00214":null,"YDL230W":null},"has_protein_features":false,"name":"PTP1","ortholog_annotations":[{"gene_uniquename":"YDL230W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00214","reference_uniquename":"PMID:29761456"}],"product":"Phosphotyrosine-specific protein phosphatase; dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL230W"}


id: YDL231C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02011":null,"SJAG_04423":null,"YDL231C":null},"has_protein_features":false,"name":"BRE4","ortholog_annotations":[{"gene_uniquename":"YDL231C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02011","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL231C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04423","reference_uniquename":"PMID:29761456"}],"product":"Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL231C"}


id: YDL232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05348":null,"YDL232W":null},"has_protein_features":false,"name":"OST4","ortholog_annotations":[{"gene_uniquename":"YDL232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05348","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL232W"}


id: YDL233W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02255":null,"YDL233W":null},"has_protein_features":false,"name":"MFG1","ortholog_annotations":[{"gene_uniquename":"YDL233W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02255","reference_uniquename":"PMID:29761456"}],"product":"Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL233W"}


id: YDL234C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03021":null,"YDL234C":null},"has_protein_features":false,"name":"GYP7","ortholog_annotations":[{"gene_uniquename":"YDL234C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03021","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein for yeast Rab family members; members include Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking; contains a PH-like domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL234C"}


id: YDL235C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06592":null,"YDL235C":null},"has_protein_features":false,"name":"YPD1","ortholog_annotations":[{"gene_uniquename":"YDL235C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06592","reference_uniquename":"PMID:29761456"}],"product":"Osmotic stress-responsive phosphorelay intermediate sensor protein; phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002394","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL235C"}


id: YDL236W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03108":null,"YDL236W":null},"has_protein_features":false,"name":"PHO13","ortholog_annotations":[{"gene_uniquename":"YDL236W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03108","reference_uniquename":"PMID:29761456"}],"product":"Conserved phosphatase acting as a metabolite repair enzyme; shows specific dephosphorylating activity on two side-products of central carbohydrate metabolism, 2-phosphoglycolate and 4-phosphoerythronate; alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity; human ortholog PGP shows similar substrate specificity, deletion causes similar metabolite accumulation phenotypes, suggesting conserved role in eliminating glycolytic byproducts","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002395","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL236W"}


id: YDL237W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM6","product":"Protein of unknown function; required for respiratory growth; YDL237W is not an essential gene","secondary_identifier":"SGD:S000002396","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL237W"}


id: YDL238C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01997":null,"YDL238C":null},"has_protein_features":false,"name":"GUD1","ortholog_annotations":[{"gene_uniquename":"YDL238C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01997","reference_uniquename":"PMID:29761456"}],"product":"Guanine deaminase; a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002397","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL238C"}


id: YDL239C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01464":null,"YDL239C":null},"has_protein_features":false,"name":"ADY3","ortholog_annotations":[{"gene_uniquename":"YDL239C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01464","reference_uniquename":"PMID:29761456"}],"product":"Protein required for spore wall formation; subunit of leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms ring-like structure at leading edge of prospore membrane during meiosis II; mediates assembly of LEP complex, formation of ring-like structure via interaction with spindle pole body components, and prospore membrane maturation; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002398","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL239C"}


id: YDL240C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by sequence comparison with hemiascomycetous yeast species","secondary_identifier":"SGD:S000007601","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL240C-A"}


id: YDL240W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00551":null,"SJAG_03655":null,"YDL240W":null},"has_protein_features":false,"name":"LRG1","ortholog_annotations":[{"gene_uniquename":"YDL240W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00551","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL240W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03655","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein (GAP); contains Rho1p-specific GAP activity, interacting with activated forms of Rho1p; functions along with Sac7p as a negative regulator of the Pkc1p-mediated cell wall integrity signaling pathway; negative regulator of cell wall 1,3-beta-glucan biosynthesis; required for efficient cell fusion; contains a RhoGAP domain and three Lin-11-Isl1-Mec-3 (LIM) domains","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002399","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL240W"}


id: YDL241W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YDL241W is not an essential gene","secondary_identifier":"SGD:S000002400","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL241W"}


id: YDL242W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000002401","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL242W"}


id: YDL243C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AAD4","product":"Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family","secondary_identifier":"SGD:S000002402","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL243C"}


id: YDL244W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04866":null,"YDL244W":null},"has_protein_features":false,"name":"THI13","ortholog_annotations":[{"gene_uniquename":"YDL244W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04866","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002403","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL244W"}


id: YDL245C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YDL245C":null},"has_protein_features":false,"name":"HXT15","ortholog_annotations":[{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002404","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL245C"}


id: YDL246C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00237":null,"YDL246C":null},"has_protein_features":false,"name":"SOR2","ortholog_annotations":[{"gene_uniquename":"YDL246C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00237","reference_uniquename":"PMID:29761456"}],"product":"Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002405","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL246C"}


id: YDL247W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MPH2","product":"Alpha-glucoside permease; transports maltose, maltotriose, alpha-methylglucoside, and turanose; almost identical to Mph3p; encoded in a subtelomeric position in a region likely to have undergone duplication","secondary_identifier":"SGD:S000002406","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL247W"}


id: YDL247W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by sequence comparison with hemiascomycetous yeast species","secondary_identifier":"SGD:S000007602","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL247W-A"}


id: YDL248W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS7","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000002407","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL248W"}


id: YDR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04859":null,"YDR001C":null},"has_protein_features":false,"name":"NTH1","ortholog_annotations":[{"gene_uniquename":"YDR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04859","reference_uniquename":"PMID:29761456"}],"product":"Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; phosphorylated and activated by Cdc28p at the G1/S phase transition to coordinately regulate carbohydrate metabolism and the cell cycle; inhibited by Dcs1p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002408","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR001C"}


id: YDR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02520":null,"YDR002W":null},"has_protein_features":false,"name":"YRB1","ortholog_annotations":[{"gene_uniquename":"YDR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02520","reference_uniquename":"PMID:29761456"}],"product":"Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002409","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR002W"}


id: YDR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01258":null,"YDR003W":null},"has_protein_features":false,"name":"RCR2","ortholog_annotations":[{"gene_uniquename":"YDR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01258","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar ubiquitin ligase-substrate adaptor; delivered to vacuole using ubiquitin as a sorting signal; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002410","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR003W"}


id: YDR003W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028819","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR003W-A"}


id: YDR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00757":null,"YDR004W":null},"has_protein_features":false,"name":"RAD57","ortholog_annotations":[{"gene_uniquename":"YDR004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00757","reference_uniquename":"PMID:29761456"}],"product":"Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002411","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR004W"}


id: YDR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02898":null,"YDR005C":null},"has_protein_features":false,"name":"MAF1","ortholog_annotations":[{"gene_uniquename":"YDR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02898","reference_uniquename":"PMID:29761456"}],"product":"Highly conserved negative regulator of RNA polymerase III; involved in tRNA processing and stability; inhibits tRNA degradation via rapid tRNA decay (RTD) pathway; binds N-terminal domain of Rpc160p subunit of Pol III to prevent closed-complex formation; regulated by phosphorylation mediated by TORC1, protein kinase A, Sch9p, casein kinase 2; localizes to cytoplasm during vegetative growth and translocates to nucleus and nucleolus under stress conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002412","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR005C"}


id: YDR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SOK1","product":"Protein of unknown function; overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13","secondary_identifier":"SGD:S000002413","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR006C"}


id: YDR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TRP1","product":"Phosphoribosylanthranilate isomerase; catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA); enhances vegetative growth at low and high temperatures when used as an auxotrophic marker in strains such as W303","secondary_identifier":"SGD:S000002414","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR007W"}


id: YDR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps TRP1/YDR007W on opposite strand","secondary_identifier":"SGD:S000002415","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR008C"}


id: YDR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02950":null,"YDR009W":null},"has_protein_features":false,"name":"GAL3","ortholog_annotations":[{"gene_uniquename":"YDR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02950","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002416","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR009W"}


id: YDR010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000002417","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR010C"}


id: YDR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04277":null,"YDR011W":null},"has_protein_features":false,"name":"SNQ2","ortholog_annotations":[{"gene_uniquename":"YDR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002418","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR011W"}


id: YDR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06612":null,"YDR012W":null},"has_protein_features":false,"name":"RPL4B","ortholog_annotations":[{"gene_uniquename":"YDR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06612","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L4B; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4B has a paralog, RPL4A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002419","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR012W"}


id: YDR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00874":null,"YDR013W":null},"has_protein_features":false,"name":"PSF1","ortholog_annotations":[{"gene_uniquename":"YDR013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00874","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002420","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR013W"}


id: YDR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02606":null,"YDR014W":null},"has_protein_features":false,"name":"RAD61","ortholog_annotations":[{"gene_uniquename":"YDR014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02606","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a complex that inhibits sister chromatid cohesion; also negatively regulates chromosome condensation; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; binds Smc3p ATPase head of cohesin; related to the human Wapl protein that controls the association of cohesin with chromatin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR014W"}


id: YDR014W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HED1","product":"Meiosis-specific protein; down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; promotes synapsis and required for the normal morphogenesis of synaptonemal complex; prevents the recruitment of Rad54p to site-specific DNA double-strand breaks in vivo; early meiotic gene, transcribed specifically during meiotic prophase","secondary_identifier":"SGD:S000113613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR014W-A"}


id: YDR015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A","secondary_identifier":"SGD:S000002422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR015C"}


id: YDR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01775":null,"YDR016C":null},"has_protein_features":false,"name":"DAD1","ortholog_annotations":[{"gene_uniquename":"YDR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01775","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR016C"}


id: YDR017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02321":null,"YDR017C":null},"has_protein_features":false,"name":"KCS1","ortholog_annotations":[{"gene_uniquename":"YDR017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02321","reference_uniquename":"PMID:29761456"}],"product":"Inositol hexakisphosphate and inositol heptakisphosphate kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response, RNA polymerase I-mediated rRNA transcription and telomere maintenance; inositol hexakisphosphate is also known as IP6; inositol heptakisphosphate is also known as IP7","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002424","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR017C"}


id: YDR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03935":null,"YDR018C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03935","reference_uniquename":"PMID:29761456"}],"product":"Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR018C"}


id: YDR019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02901":null,"YDR019C":null},"has_protein_features":false,"name":"GCV1","ortholog_annotations":[{"gene_uniquename":"YDR019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02901","reference_uniquename":"PMID:29761456"}],"product":"T subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002426","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR019C"}


id: YDR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DAS2","product":"Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases","secondary_identifier":"SGD:S000002427","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR020C"}


id: YDR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02879":null,"YDR021W":null},"has_protein_features":false,"name":"FAL1","ortholog_annotations":[{"gene_uniquename":"YDR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02879","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein required for maturation of 18S rRNA; member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; 18S rRNA biogenesis defect of the null mutant is functionally complemented by human EIF4A3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002428","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR021W"}


id: YDR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG31","product":"Autophagy-specific protein required for autophagosome formation; forms a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; constitutively phosphorylated, and phosphorylation of residue S174 is required for function; high-copy suppressor of CIK1 deletion","secondary_identifier":"SGD:S000002429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR022C"}


id: YDR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04762":null,"YDR023W":null},"has_protein_features":false,"name":"SES1","ortholog_annotations":[{"gene_uniquename":"YDR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04762","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic seryl-tRNA synthetase; class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002430","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR023W"}


id: YDR024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FYV1","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin","secondary_identifier":"SGD:S000002431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR024W"}


id: YDR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00069":null,"SJAG_00503":null,"YDR025W":null},"has_protein_features":false,"name":"RPS11A","ortholog_annotations":[{"gene_uniquename":"YDR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00069","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00503","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; N-terminally propionylated in vivo; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002432","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR025W"}


id: YDR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00073":null,"SJAG_02922":null,"SJAG_04855":null,"YDR026C":null},"has_protein_features":false,"name":"NSI1","ortholog_annotations":[{"gene_uniquename":"YDR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00073","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02922","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04855","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002433","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR026C"}


id: YDR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03963":null,"YDR027C":null},"has_protein_features":false,"name":"VPS54","ortholog_annotations":[{"gene_uniquename":"YDR027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03963","reference_uniquename":"PMID:29761456"}],"product":"Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; potentially phosphorylated by Cdc28p; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR027C"}


id: YDR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00534":null,"YDR028C":null},"has_protein_features":false,"name":"REG1","ortholog_annotations":[{"gene_uniquename":"YDR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00534","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; REG1 has a paralog, REG2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR028C"}


id: YDR029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YDR029W is not an essential gene","secondary_identifier":"SGD:S000002436","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR029W"}


id: YDR030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04540":null,"YDR030C":null},"has_protein_features":false,"name":"RAD28","ortholog_annotations":[{"gene_uniquename":"YDR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04540","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in DNA repair; related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002437","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR030C"}


id: YDR031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIX14","product":"Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000002438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR031W"}


id: YDR032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02697":null,"YDR032C":null},"has_protein_features":false,"name":"PST2","ortholog_annotations":[{"gene_uniquename":"YDR032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02697","reference_uniquename":"PMID:29761456"}],"product":"FMN-dependent NAD(P)H:quinone oxidoreductase; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR032C"}


id: YDR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02533":null,"YDR033W":null},"has_protein_features":false,"name":"MRH1","ortholog_annotations":[{"gene_uniquename":"YDR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02533","reference_uniquename":"PMID:29761456"}],"product":"Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; long-lived protein that is asymmetrically retained in the plasma membrane of mother cells; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; null mutation confers sensitivity to acetic acid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002440","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR033W"}


id: YDR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LYS14","product":"Transcriptional activator involved in regulating lysine biosynthesis; involved in the regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer","secondary_identifier":"SGD:S000002441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR034C"}


id: YDR034C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; contained within the solo Ty1 LTR element YDRWdelta7","secondary_identifier":"SGD:S000007233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR034C-A"}


id: YDR034W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Predicted tail-anchored plasma membrane protein; contains conserved CYSTM module; related proteins in other organisms may be involved in response to stress; N- and C-terminal fusion proteins localize to the cell periphery; YDR034W-B has a paralog, YBR056W-A, that arose from the whole genome duplication","secondary_identifier":"SGD:S000007234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR034W-B"}


id: YDR035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00224":null,"SJAG_03580":null,"YDR035W":null},"has_protein_features":false,"name":"ARO3","ortholog_annotations":[{"gene_uniquename":"YDR035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00224","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03580","reference_uniquename":"PMID:29761456"}],"product":"3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002442","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR035W"}


id: YDR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00944":null,"YDR036C":null},"has_protein_features":false,"name":"EHD3","ortholog_annotations":[{"gene_uniquename":"YDR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00944","reference_uniquename":"PMID:29761456"}],"product":"3-hydroxyisobutyryl-CoA hydrolase; member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002443","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR036C"}


id: YDR037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00488":null,"YDR037W":null},"has_protein_features":false,"name":"KRS1","ortholog_annotations":[{"gene_uniquename":"YDR037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00488","reference_uniquename":"PMID:29761456"}],"product":"Lysyl-tRNA synthetase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002444","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR037W"}


id: YDR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04167":null,"YDR038C":null},"has_protein_features":false,"name":"ENA5","ortholog_annotations":[{"gene_uniquename":"YDR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04167","reference_uniquename":"PMID:29761456"}],"product":"Protein with similarity to P-type ATPase sodium pumps; member of the Na+ efflux ATPase family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002445","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR038C"}


id: YDR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04167":null,"YDR039C":null},"has_protein_features":false,"name":"ENA2","ortholog_annotations":[{"gene_uniquename":"YDR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04167","reference_uniquename":"PMID:29761456"}],"product":"P-type ATPase sodium pump; involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002446","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR039C"}


id: YDR040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04167":null,"YDR040C":null},"has_protein_features":false,"name":"ENA1","ortholog_annotations":[{"gene_uniquename":"YDR040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04167","reference_uniquename":"PMID:29761456"}],"product":"P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002447","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR040C"}


id: YDR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00860":null,"YDR041W":null},"has_protein_features":false,"name":"RSM10","ortholog_annotations":[{"gene_uniquename":"YDR041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00860","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002448","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR041W"}


id: YDR042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; expression is increased in ssu72-ts69 mutant","secondary_identifier":"SGD:S000002449","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR042C"}


id: YDR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00124":null,"YDR043C":null},"has_protein_features":false,"name":"NRG1","ortholog_annotations":[{"gene_uniquename":"YDR043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00124","reference_uniquename":"PMID:26896847"}],"product":"Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; activated in stochastic pulses of nuclear localization in response to low glucose","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000002450","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR043C"}


id: YDR044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04944":null,"YDR044W":null},"has_protein_features":false,"name":"HEM13","ortholog_annotations":[{"gene_uniquename":"YDR044W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04944","reference_uniquename":"PMID:29761456"}],"product":"Coproporphyrinogen III oxidase; oxygen-requiring enzyme that catalyzes sixth step in heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p); human homolog CPOX can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002451","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR044W"}


id: YDR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03761":null,"YDR045C":null},"has_protein_features":false,"name":"RPC11","ortholog_annotations":[{"gene_uniquename":"YDR045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03761","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002452","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR045C"}


id: YDR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YDR046C":null},"has_protein_features":false,"name":"BAP3","ortholog_annotations":[{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002453","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR046C"}


id: YDR047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04109":null,"YDR047W":null},"has_protein_features":false,"name":"HEM12","ortholog_annotations":[{"gene_uniquename":"YDR047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04109","reference_uniquename":"PMID:29761456"}],"product":"Uroporphyrinogen decarboxylase; catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002454","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR047W"}


id: YDR048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF VMS1/YDR049W","secondary_identifier":"SGD:S000002455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR048C"}


id: YDR049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00948":null,"YDR049W":null},"has_protein_features":false,"name":"VMS1","ortholog_annotations":[{"gene_uniquename":"YDR049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00948","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, component of a Cdc48p-complex; involved in protein quality control; exhibits cytosolic and ER-membrane localization; contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; translocates to mitochondria under oxidative stress and forms a complex with Cdc48p and Npl4p that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002456","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR049W"}


id: YDR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04192":null,"YDR050C":null},"has_protein_features":false,"name":"TPI1","ortholog_annotations":[{"gene_uniquename":"YDR050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04192","reference_uniquename":"PMID:29761456"}],"product":"Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human homolog TPI1 causes a rare autosomal disease; human TPI1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002457","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR050C"}


id: YDR051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DET1","product":"Acid phosphatase; involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel","secondary_identifier":"SGD:S000002458","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR051C"}


id: YDR052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03090":null,"SJAG_03695":null,"YDR052C":null},"has_protein_features":false,"name":"DBF4","ortholog_annotations":[{"gene_uniquename":"YDR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03090","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03695","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress; co-expression of human CDC7 and DBF4 complements single cdc7 or dbf4 null mutations or the cdc7 dbf4 double null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002459","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR052C"}


id: YDR053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex","secondary_identifier":"SGD:S000002460","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR053W"}


id: YDR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00300":null,"YDR054C":null},"has_protein_features":false,"name":"CDC34","ortholog_annotations":[{"gene_uniquename":"YDR054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00300","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress; human CDC34 functionally complements the thermosensitivity of the cdc34-2 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002461","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR054C"}


id: YDR055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00340":null,"SJAG_03483":null,"YDR055W":null},"has_protein_features":false,"name":"PST1","ortholog_annotations":[{"gene_uniquename":"YDR055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00340","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03483","reference_uniquename":"PMID:29761456"}],"product":"Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1; PST1 has a paralog, ECM33, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002462","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR055W"}


id: YDR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01999":null,"YDR056C":null},"has_protein_features":false,"name":"EMC10","ortholog_annotations":[{"gene_uniquename":"YDR056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01999","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5p of TOM (Translocase of the Mitochondrial Outer Membrane) complex; YDR056C is not an essential protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002463","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR056C"}


id: YDR057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00530":null,"YDR057W":null},"has_protein_features":false,"name":"YOS9","ortholog_annotations":[{"gene_uniquename":"YDR057W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00530","reference_uniquename":"PMID:29761456"}],"product":"ER quality-control lectin; integral subunit of the HRD ligase; participates in efficient ER retention of misfolded proteins by recognizing them and delivering them to Hrd1p; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002464","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR057W"}


id: YDR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TGL2","product":"Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli","secondary_identifier":"SGD:S000002465","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR058C"}


id: YDR059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04573":null,"YDR059C":null},"has_protein_features":false,"name":"UBC5","ortholog_annotations":[{"gene_uniquename":"YDR059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04573","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002466","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR059C"}


id: YDR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01275":null,"SJAG_01779":null,"YDR060W":null},"has_protein_features":false,"name":"MAK21","ortholog_annotations":[{"gene_uniquename":"YDR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01275","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01779","reference_uniquename":"PMID:29761456"}],"product":"Constituent of 66S pre-ribosomal particles; required for large (60S) ribosomal subunit biogenesis; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002467","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR060W"}


id: YDR061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03948":null,"YDR061W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03948","reference_uniquename":"PMID:29761456"}],"product":"Protein with similarity to ABC transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002468","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR061W"}


id: YDR062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02305":null,"YDR062W":null},"has_protein_features":false,"name":"LCB2","ortholog_annotations":[{"gene_uniquename":"YDR062W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02305","reference_uniquename":"PMID:29761456"}],"product":"Component of serine palmitoyltransferase; responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002469","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR062W"}


id: YDR063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03455":null,"YDR063W":null},"has_protein_features":false,"name":"AIM7","ortholog_annotations":[{"gene_uniquename":"YDR063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03455","reference_uniquename":"PMID:29761456"}],"product":"Protein that interacts with Arp2/3 complex; interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002470","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR063W"}


id: YDR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01132":null,"SJAG_01387":null,"YDR064W":null},"has_protein_features":false,"name":"RPS13","ortholog_annotations":[{"gene_uniquename":"YDR064W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01132","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR064W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01387","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002471","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR064W"}


id: YDR065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRG1","product":"Protein of unknown function; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; required for vacuolar acidification; localizes to the matrix side of the inner mitochondrial membrane","secondary_identifier":"SGD:S000002472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR065W"}


id: YDR066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RTR2","product":"Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002473","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR066C"}


id: YDR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OCA6","product":"Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT","secondary_identifier":"SGD:S000002474","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR067C"}


id: YDR068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00791":null,"YDR068W":null},"has_protein_features":false,"name":"DOS2","ortholog_annotations":[{"gene_uniquename":"YDR068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00791","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002475","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR068W"}


id: YDR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03429":null,"YDR069C":null},"has_protein_features":false,"name":"DOA4","ortholog_annotations":[{"gene_uniquename":"YDR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03429","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin hydrolase; deubiquitinates intralumenal vesicle (ILVs) cargo proteins; required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins destined for the vacuole; DOA4 has a paralog, UBP5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002476","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR069C"}


id: YDR070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMP16","product":"Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000002477","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR070C"}


id: YDR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02296":null,"YDR071C":null},"has_protein_features":false,"name":"PAA1","ortholog_annotations":[{"gene_uniquename":"YDR071C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02296","reference_uniquename":"PMID:29761456"}],"product":"Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002478","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR071C"}


id: YDR072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00506":null,"YDR072C":null},"has_protein_features":false,"name":"IPT1","ortholog_annotations":[{"gene_uniquename":"YDR072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00506","reference_uniquename":"PMID:29761456"}],"product":"Inositolphosphotransferase; involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002479","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR072C"}


id: YDR073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00743":null,"YDR073W":null},"has_protein_features":false,"name":"SNF11","ortholog_annotations":[{"gene_uniquename":"YDR073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00743","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002480","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR073W"}


id: YDR074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01646":null,"SJAG_01862":null,"YDR074W":null},"has_protein_features":false,"name":"TPS2","ortholog_annotations":[{"gene_uniquename":"YDR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01646","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01862","reference_uniquename":"PMID:29761456"}],"product":"Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in the synthesis of storage carbohydrate trehalose; positive regulator of autophagy involved in the dephosphorylation of Rim15p leading to ATG8 induction; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002481","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR074W"}


id: YDR075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00823":null,"YDR075W":null},"has_protein_features":false,"name":"PPH3","ortholog_annotations":[{"gene_uniquename":"YDR075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00823","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form active complex, Psy4p may provide substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002482","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR075W"}


id: YDR076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02708":null,"YDR076W":null},"has_protein_features":false,"name":"RAD55","ortholog_annotations":[{"gene_uniquename":"YDR076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02708","reference_uniquename":"PMID:29761456"}],"product":"Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002483","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR076W"}


id: YDR077W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SED1","product":"Major stress-induced structural GPI-cell wall glycoprotein; associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites; SED1 has a paralog, SPI1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002484","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR077W"}


id: YDR078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03051":null,"YDR078C":null},"has_protein_features":false,"name":"SHU2","ortholog_annotations":[{"gene_uniquename":"YDR078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03051","reference_uniquename":"PMID:29761456"}],"product":"Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu1, and promotes error-free DNA repair, Shu complex mediates inhibition of Srs2p function; promotes formation of Rad51p filaments; important for both mitotic and meiotic homologous recombination, and contains a conserved SWIM domain that is necessary for both","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002485","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR078C"}


id: YDR079C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01207":null,"YDR079C-A":null},"has_protein_features":false,"name":"TFB5","ortholog_annotations":[{"gene_uniquename":"YDR079C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01207","reference_uniquename":"PMID:29761456"}],"product":"Component of RNA polymerase II general transcription factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; relocalizes to the cytosol in response to hypoxia; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007603","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR079C-A"}


id: YDR079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PET100","product":"Chaperone that facilitates the assembly of cytochrome c oxidase; integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme","secondary_identifier":"SGD:S000002486","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR079W"}


id: YDR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00380":null,"YDR080W":null},"has_protein_features":false,"name":"VPS41","ortholog_annotations":[{"gene_uniquename":"YDR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00380","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the HOPS endocytic tethering complex; vacuole membrane protein that functions as a Rab GTPase effector, interacting specifically with the GTP-bound conformation of Ypt7p, facilitating tethering, docking and promoting membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; Yck3p-mediated phosphorylation regulates the organization of vacuolar fusion sites","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002487","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR080W"}


id: YDR081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PDC2","product":"Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions","secondary_identifier":"SGD:S000002488","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR081C"}


id: YDR082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02362":null,"YDR082W":null},"has_protein_features":false,"name":"STN1","ortholog_annotations":[{"gene_uniquename":"YDR082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02362","reference_uniquename":"PMID:29761456"}],"product":"Telomere end-binding and capping protein; plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping; similar to human Stn1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002489","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR082W"}


id: YDR083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03713":null,"YDR083W":null},"has_protein_features":false,"name":"RRP8","ortholog_annotations":[{"gene_uniquename":"YDR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03713","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with gar1 mutation; deletion disrupts telomere maintenance by influencing expression of neighboring gene STN1; mammalian homolog nucleomethylin has been linked to nutrient availability signaling pathways and obesity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002490","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR083W"}


id: YDR084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00553":null,"YDR084C":null},"has_protein_features":false,"name":"TVP23","ortholog_annotations":[{"gene_uniquename":"YDR084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00553","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002491","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR084C"}


id: YDR085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AFR1","product":"Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002492","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR085C"}


id: YDR086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00959":null,"YDR086C":null},"has_protein_features":false,"name":"SSS1","ortholog_annotations":[{"gene_uniquename":"YDR086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00959","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p); this complex forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002493","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR086C"}


id: YDR087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03458":null,"YDR087C":null},"has_protein_features":false,"name":"RRP1","ortholog_annotations":[{"gene_uniquename":"YDR087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03458","reference_uniquename":"PMID:29761456"}],"product":"Essential evolutionarily conserved nucleolar protein; necessary for biogenesis of 60S ribosomal subunits and for processing of pre-rRNAs to mature rRNA; associated with several distinct 66S pre-ribosomal particles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002494","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR087C"}


id: YDR088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01200":null,"YDR088C":null},"has_protein_features":false,"name":"SLU7","ortholog_annotations":[{"gene_uniquename":"YDR088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01200","reference_uniquename":"PMID:29761456"}],"product":"RNA splicing factor; required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002495","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR088C"}


id: YDR089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VTC5","product":"Novel subunit of the vacuolar transporter chaperone complex; vacuolar transmembrane protein that regulates biosynthesis of polyphosphate; deletion reduces and overexpression increases polyP accumulation; SPX domain (Syg1, Pho81, Xpr1)-containing protein involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000002496","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR089W"}


id: YDR090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00051":null,"SJAG_04787":null,"YDR090C":null},"has_protein_features":false,"name":"ILT1","ortholog_annotations":[{"gene_uniquename":"YDR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00051","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04787","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; deletion confers sensitivity to cationic compounds; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002497","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR090C"}


id: YDR091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03658":null,"YDR091C":null},"has_protein_features":false,"name":"RLI1","ortholog_annotations":[{"gene_uniquename":"YDR091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03658","reference_uniquename":"PMID:29761456"}],"product":"Essential Fe-S protein; required for ribosome biogenesis, translation initiation/termination; facilitates binding of multifactor complex (MFC) of initiation factors to small ribosomal subunit; Dom34-Hbs1 complex and Rli1p work in dissociating inactive ribosomes, thereby facilitating translation restart; forms complex with Lto1p and Yae1p; dependency on ROS-labile FeS clusters, activity in nuclear ribosomal-subunit export impaired by mild oxidative stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002498","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR091C"}


id: YDR092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00208":null,"YDR092W":null},"has_protein_features":false,"name":"UBC13","ortholog_annotations":[{"gene_uniquename":"YDR092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00208","reference_uniquename":"PMID:29761456"}],"product":"E2 ubiquitin-conjugating enzyme; involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002499","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR092W"}


id: YDR093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01731":null,"SJAG_02897":null,"YDR093W":null},"has_protein_features":false,"name":"DNF2","ortholog_annotations":[{"gene_uniquename":"YDR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01731","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02897","reference_uniquename":"PMID:29761456"}],"product":"Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF2 has a paralog, DNF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002500","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR093W"}


id: YDR094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2/YDR093W","secondary_identifier":"SGD:S000002501","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR094W"}


id: YDR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002502","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR095C"}


id: YDR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03041":null,"YDR096W":null},"has_protein_features":false,"name":"GIS1","ortholog_annotations":[{"gene_uniquename":"YDR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03041","reference_uniquename":"PMID:29761456"}],"product":"Histone demethylase and transcription factor; regulates genes during nutrient limitation; activity modulated by proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminus that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; relocalizes to the cytosol in response to hypoxia; GIS1 has a paralog, RPH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002503","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR096W"}


id: YDR097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02748":null,"YDR097C":null},"has_protein_features":false,"name":"MSH6","ortholog_annotations":[{"gene_uniquename":"YDR097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02748","reference_uniquename":"PMID:29761456"}],"product":"Protein required for mismatch repair in mitosis and meiosis; forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p; contains PIP motif that binds PCNA (Pol30p) and Rev1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002504","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR097C"}


id: YDR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00822":null,"YDR098C":null},"has_protein_features":false,"name":"GRX3","ortholog_annotations":[{"gene_uniquename":"YDR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00822","reference_uniquename":"PMID:29761456"}],"product":"Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive monothiol glutaredoxin subfamily member with Grx4p and Grx5p; redundantly protects cells from oxidative damage along with GRX4 and GRX5; with Grx4p, promotes the dissociation of Aft1p from iron regulon gene promoters and subsequent nuclear export in iron-replete conditions, regulating iron homeostasis; involved with Grx4p in the deglutathionylation of Sir2p, restoring deacetylase activity after disulfide stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002505","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR098C"}


id: YDR099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02266":null,"SJAG_02576":null,"YDR099W":null},"has_protein_features":false,"name":"BMH2","ortholog_annotations":[{"gene_uniquename":"YDR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02266","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02576","reference_uniquename":"PMID:29761456"}],"product":"14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; abundance relative to Bmh1p increases during sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002506","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR099W"}


id: YDR100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03368":null,"YDR100W":null},"has_protein_features":false,"name":"TVP15","ortholog_annotations":[{"gene_uniquename":"YDR100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03368","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002507","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR100W"}


id: YDR101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00479":null,"YDR101C":null},"has_protein_features":false,"name":"ARX1","ortholog_annotations":[{"gene_uniquename":"YDR101C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00479","reference_uniquename":"PMID:29761456"}],"product":"Nuclear export factor for the ribosomal pre-60S subunit; shuttling factor which directly binds FG rich nucleoporins and facilities translocation through the nuclear pore complex; interacts directly with Alb1p; responsible for Tif6p recycling defects in the absence of Rei1; associated with the ribosomal export complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002508","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR101C"}


id: YDR102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YDR102C is not an essential gene; homozygous diploid deletion strain exhibits high budding index","secondary_identifier":"SGD:S000002509","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR102C"}


id: YDR103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STE5","product":"Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains blocks activation of assembled signaling cascade components (Ste11p, Ste7p and Fus3p) under basal conditions; Gbeta-gamma (Ste4p-Ste18p)-dependent docking at the plasma membrane and binding of PI(4,5)P2 by the PH domain relieves autoinhibition, resulting in pheromone-dependent pathway activation","secondary_identifier":"SGD:S000002510","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR103W"}


id: YDR104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPO71","product":"Meiosis-specific protein required for prospore membrane morphogenesis; localizes to the prospore membrane (PSM) during sporulation; required for PSM elongation and closure; genetically antagonistic to SPO1; recruits Vps13p to the PSM during sporulation; interacts and functions cooperatively with Spo73p; mutants have defects in the PSM, aberrant spore wall formation and reduced PtdIns-phosphate pools in the PSM; contains three PH-like domains","secondary_identifier":"SGD:S000002511","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR104C"}


id: YDR105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03076":null,"YDR105C":null},"has_protein_features":false,"name":"TMS1","ortholog_annotations":[{"gene_uniquename":"YDR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03076","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane protein of unknown function; is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002512","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR105C"}


id: YDR106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05185":null,"YDR106W":null},"has_protein_features":false,"name":"ARP10","ortholog_annotations":[{"gene_uniquename":"YDR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05185","reference_uniquename":"PMID:29761456"}],"product":"Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002513","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR106W"}


id: YDR107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00299":null,"YDR107C":null},"has_protein_features":false,"name":"TMN2","ortholog_annotations":[{"gene_uniquename":"YDR107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00299","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in cellular adhesion and filamentous growth; similar to Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments; TMN2 has a paralog, EMP70, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002514","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR107C"}


id: YDR108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00820":null,"SJAG_00850":null,"YDR108W":null},"has_protein_features":false,"name":"TRS85","ortholog_annotations":[{"gene_uniquename":"YDR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00850","reference_uniquename":"PMID:29761456"}],"product":"Component of transport protein particle (TRAPP) complex III; TRAPPIII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating endosome-Golgi traffic and required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002515","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR108W"}


id: YDR109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"D-ribulokinase; carbohydrate kinase that specifically converts D-ribulose to D-ribulose 5-phosphate during pentose metabolism; null mutant accumulates D-ribulose and the precursor ribitol; proposed to function as a D-ribulose metabolic repair enzyme; member of the FGGY family of carbohydrate kinases; human homolog, FGGY, is involved in both D-ribulose and ribitol metabolism; human FGGY has been linked to both sporadic amyotrophic lateral sclerosis and bipolar disorder","secondary_identifier":"SGD:S000002516","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR109C"}


id: YDR110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FOB1","product":"Nucleolar protein that binds the rDNA replication fork barrier site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to replication fork barrier (RFB), and rDNA repeat segregation; related to retroviral integrases","secondary_identifier":"SGD:S000002517","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR110W"}


id: YDR111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04145":null,"YDR111C":null},"has_protein_features":false,"name":"ALT2","ortholog_annotations":[{"gene_uniquename":"YDR111C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04145","reference_uniquename":"PMID:29761456"}],"product":"Catalytically inactive alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p; ALT2 has a paralog, ALT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002518","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR111C"}


id: YDR112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC2","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ALT2/YDR111C; null mutant displays increased levels of spontaneous Rad52p foci","secondary_identifier":"SGD:S000002519","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR112W"}


id: YDR113C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00460":null,"YDR113C":null},"has_protein_features":false,"name":"PDS1","ortholog_annotations":[{"gene_uniquename":"YDR113C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00460","reference_uniquename":"PMID:29761456"}],"product":"Securin; inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002520","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR113C"}


id: YDR114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium","secondary_identifier":"SGD:S000002521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR114C"}


id: YDR115W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00497":null,"YDR115W":null},"has_protein_features":false,"name":"MRX14","ortholog_annotations":[{"gene_uniquename":"YDR115W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00497","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial ribosomal protein of the large subunit; required for respiratory growth and for efficient translation of mitochondrial COX1 and COX3;  conditional mutant has reduced cytochrome c oxidase activity; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress; contains and N-terminal mitochondrial targeting sequence; similar to E. coli L34 ribosomal protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR115W"}


id: YDR116C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03284":null,"YDR116C":null},"has_protein_features":false,"name":"MRPL1","ortholog_annotations":[{"gene_uniquename":"YDR116C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03284","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR116C"}


id: YDR117C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TMA64","product":"Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity","secondary_identifier":"SGD:S000002524","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR117C"}


id: YDR118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02186":null,"YDR118W":null},"has_protein_features":false,"name":"APC4","ortholog_annotations":[{"gene_uniquename":"YDR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02186","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002525","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR118W"}


id: YDR118W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified using a combination of expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028820","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR118W-A"}


id: YDR119W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VBA4","product":"Protein of unknown function; proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene","secondary_identifier":"SGD:S000002526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR119W"}


id: YDR119W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COX26","product":"Subunit of cytochrome C oxidase complex; stabilizes or regulates formation of respiratory chain supercomplexes composed of Complex III (ubiquinol-cytochrome c reductase) and Complex IV (cytochrome c oxidase)","secondary_identifier":"SGD:S000113555","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR119W-A"}


id: YDR120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00886":null,"YDR120C":null},"has_protein_features":false,"name":"TRM1","ortholog_annotations":[{"gene_uniquename":"YDR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00886","reference_uniquename":"PMID:29761456"}],"product":"tRNA methyltransferase; two forms of protein are made by alternative translation starts; localizes to both nucleus and mitochondrion to produce modified base N2,N2-dimethylguanosine in tRNAs in both compartments; nuclear Trm1p is evenly distributed around inner nuclear membrane in WT, but mislocalizes as puncta near ER-nucleus junctions in spindle pole body (SPB) mutants; both Trm1p inner nuclear membrane targeting and maintenance depend upon SPB","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002527","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR120C"}


id: YDR121W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04879":null,"YDR121W":null},"has_protein_features":false,"name":"DPB4","ortholog_annotations":[{"gene_uniquename":"YDR121W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04879","reference_uniquename":"PMID:29761456"}],"product":"Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002528","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR121W"}


id: YDR122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02838":null,"YDR122W":null},"has_protein_features":false,"name":"KIN1","ortholog_annotations":[{"gene_uniquename":"YDR122W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02838","reference_uniquename":"PMID:29761456"}],"product":"S/T protein kinase; regulates polarized exocytosis and the Ire1p-mediated unfolded protein response; regulates HAC1 mRNA translocation, splicing and translation with KIN2 during ER stress; direct phosphorylation of the substrate Sec9p (S190) is enhanced by prior substrate priming (S192); localizes to the cytoplasmic face of the plasma membrane; activation loop phosphorylation (T302) required for full kinase activity; orthologous to MARK/PAR-1, AMP-activated protein kinase (AMPK) family members","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002529","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR122W"}


id: YDR123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"INO2","product":"Transcription factor; component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion; involved in diauxic shift","secondary_identifier":"SGD:S000002530","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR123C"}


id: YDR124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Mitochondrial protein of unknown function; null mutant show severe fragmentation of mitochondria; expression is strongly induced by alpha factor; may have role in maintenance of mitochondrial morphology","secondary_identifier":"SGD:S000002531","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR124W"}


id: YDR125C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM18","product":"Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002532","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR125C"}


id: YDR126W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00895":null,"YDR126W":null},"has_protein_features":false,"name":"SWF1","ortholog_annotations":[{"gene_uniquename":"YDR126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00895","reference_uniquename":"PMID:29761456"}],"product":"Palmitoyltransferase that acts on transmembrane proteins; including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002533","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR126W"}


id: YDR127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00337":null,"YDR127W":null},"has_protein_features":false,"name":"ARO1","ortholog_annotations":[{"gene_uniquename":"YDR127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00337","reference_uniquename":"PMID:29761456"}],"product":"Pentafunctional arom protein; catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002534","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR127W"}


id: YDR128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00209":null,"YDR128W":null},"has_protein_features":false,"name":"MTC5","ortholog_annotations":[{"gene_uniquename":"YDR128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00209","reference_uniquename":"PMID:29761456"}],"product":"Subunit of SEACAT, a subcomplex of the SEA complex; Mtc1p, along with Rtc1p and Sea4p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; relative distribution to the vacuolar membrane decreases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002535","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR128W"}


id: YDR129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03088":null,"YDR129C":null},"has_protein_features":false,"name":"SAC6","ortholog_annotations":[{"gene_uniquename":"YDR129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03088","reference_uniquename":"PMID:29761456"}],"product":"Fimbrin, actin-bundling protein; cooperates with Scp1p in organization and maintenance of the actin cytoskeleton; phosphorylated by Cdc28p/Clb2p in metaphase on T103, to regulate conformation, and modulate actin filament binding affinity and actin cable dynamics; relocalizes from the plasma membrane to the cytoplasm upon DNA replication stress; human homologs PLS3 and LCP1 implicated in spinocerebellar ataxia type 2 (SCA2) can each complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002536","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR129C"}


id: YDR130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FIN1","product":"Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000002537","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR130C"}


id: YDR131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"F-box protein subunit of SCF ubiquitin ligase complex; substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex","secondary_identifier":"SGD:S000002538","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR131C"}


id: YDR132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRX16","product":"Protein that associates with the large mitoribosomal subunit; abundance and relative nuclear distribution to the protein increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002539","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR132C"}


id: YDR133C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps YDR134C","secondary_identifier":"SGD:S000002540","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR133C"}


id: YDR134C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CCW22","product":"Cell wall protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication; S. cerevisiae genome reference strain S288C contains an internal in-frame stop at codon 67, which in other strains encodes glutamine","secondary_identifier":"SGD:S000002541","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR134C"}


id: YDR135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01344":null,"SJAG_03785":null,"SJAG_05213":null,"YDR135C":null},"has_protein_features":false,"name":"YCF1","ortholog_annotations":[{"gene_uniquename":"YDR135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01344","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03785","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05213","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar glutathione S-conjugate transporter; ABC-C transporter of the ATP-binding cassette family; required for vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; role in detoxifying metals (Cd, Hg, As); transports GSSG that is not immediately reduced in cytosol to vacuole; transports unconjugated bilirubin, selenodigluthatione, oxidized glutathione; similar to human cystic fibrosis protein CFTR","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002542","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR135C"}


id: YDR136C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VPS61","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect","secondary_identifier":"SGD:S000002543","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR136C"}


id: YDR137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06588":null,"YDR137W":null},"has_protein_features":false,"name":"RGP1","ortholog_annotations":[{"gene_uniquename":"YDR137W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06588","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p); this complex catalyzes nucleotide exchange on Ypt6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002544","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR137W"}


id: YDR138W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04115":null,"YDR138W":null},"has_protein_features":false,"name":"HPR1","ortholog_annotations":[{"gene_uniquename":"YDR138W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04115","reference_uniquename":"PMID:29761456"}],"product":"Subunit of THO/TREX complexes; this complex couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002545","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR138W"}


id: YDR139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00615":null,"YDR139C":null},"has_protein_features":false,"name":"RUB1","ortholog_annotations":[{"gene_uniquename":"YDR139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00615","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002546","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR139C"}


id: YDR140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03949":null,"YDR140W":null},"has_protein_features":false,"name":"MTQ2","ortholog_annotations":[{"gene_uniquename":"YDR140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03949","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine-dependent methyltransferase; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC; member of the seven beta-strand family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002547","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR140W"}


id: YDR141C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04338":null,"YDR141C":null},"has_protein_features":false,"name":"DOP1","ortholog_annotations":[{"gene_uniquename":"YDR141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04338","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in vesicular transport at trans-Golgi network (TGN); TGN-localized, leucine-zipper domain protein; involved in endosome-to-Golgi transport during endocytic recycling, and retrograde transport of glycosyltransferases from the TGN to the Golgi; involved in organization of the ER, establishment of cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002548","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR141C"}


id: YDR142C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00326":null,"YDR142C":null},"has_protein_features":false,"name":"PEX7","ortholog_annotations":[{"gene_uniquename":"YDR142C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00326","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal signal receptor for peroxisomal matrix proteins; recognizes the N-terminal nonapeptide signal (PTS2); WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002549","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR142C"}


id: YDR143C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00552":null,"YDR143C":null},"has_protein_features":false,"name":"SAN1","ortholog_annotations":[{"gene_uniquename":"YDR143C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00552","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-protein ligase; involved in proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition; prefers a window of exposed hydrophobicity that causes a particular level of protein insolubility, suggesting that San1p evolved to target highly aggregation-prone proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002550","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR143C"}


id: YDR144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00109":null,"SJAG_00254":null,"SJAG_00784":null,"SJAG_02260":null,"YDR144C":null},"has_protein_features":false,"name":"MKC7","ortholog_annotations":[{"gene_uniquename":"YDR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00109","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00254","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00784","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02260","reference_uniquename":"PMID:29761456"}],"product":"GPI-anchored aspartyl protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p; MKC7 has a paralog, YPS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002551","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR144C"}


id: YDR145W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02458":null,"YDR145W":null},"has_protein_features":false,"name":"TAF12","ortholog_annotations":[{"gene_uniquename":"YDR145W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02458","reference_uniquename":"PMID:29761456"}],"product":"Subunit (61/68 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A; overexpression of the human ortholog, TAF12, an oncogene involved in the formation of choroid plexus carcinomas, results in dosage chromosomal instability (dCIN) in a human cell line similar to the dCIN observed in yeast overexpressors","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002552","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR145W"}


id: YDR146C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02252":null,"YDR146C":null},"has_protein_features":false,"name":"SWI5","ortholog_annotations":[{"gene_uniquename":"YDR146C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02252","reference_uniquename":"PMID:26896847"}],"product":"Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000002553","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR146C"}


id: YDR147W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01918":null,"YDR147W":null},"has_protein_features":false,"name":"EKI1","ortholog_annotations":[{"gene_uniquename":"YDR147W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01918","reference_uniquename":"PMID:29761456"}],"product":"Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002554","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR147W"}


id: YDR148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03163":null,"YDR148C":null},"has_protein_features":false,"name":"KGD2","ortholog_annotations":[{"gene_uniquename":"YDR148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03163","reference_uniquename":"PMID:29761456"}],"product":"Dihydrolipoyl transsuccinylase; component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002555","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR148C"}


id: YDR149C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1/YDR150W; null mutation blocks anaerobic growth","secondary_identifier":"SGD:S000002556","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR149C"}


id: YDR150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00368":null,"YDR150W":null},"has_protein_features":false,"name":"NUM1","ortholog_annotations":[{"gene_uniquename":"YDR150W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00368","reference_uniquename":"PMID:29761456"}],"product":"Protein required for nuclear migration; component of the mitochondria-ER-cortex-anchor (MECA); required for the association of mitochondria with the cell cortex and for accurate distribution of mitochondrial network; interacts with Mdm36p to link the ER and mitochondria at the cortex; localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002557","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR150W"}


id: YDR151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04682":null,"YDR151C":null},"has_protein_features":false,"name":"CTH1","ortholog_annotations":[{"gene_uniquename":"YDR151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04682","reference_uniquename":"PMID:29761456"}],"product":"mRNA binding protein, member of the CCCH zinc finger family; similar to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; functions with Tis11p in regulation of iron homeostasis; CTH1 has a paralog, TIS11, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002558","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR151C"}


id: YDR152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04248":null,"YDR152W":null},"has_protein_features":false,"name":"GIR2","ortholog_annotations":[{"gene_uniquename":"YDR152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04248","reference_uniquename":"PMID:29761456"}],"product":"Highly-acidic RWD domain-containing cytoplasmic protein; forms a highly conserved complex with Rbg2p that is responsible for efficient cell growth under amino acid starvation and binds translational activator Gcn1p in dose-dependent manner according to stress level; associates with translating ribosomes; intrinsically unstructured protein whose stability is enhanced upon binding Rbg2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002559","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR152W"}


id: YDR153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ENT5","product":"Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin","secondary_identifier":"SGD:S000002560","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR153C"}


id: YDR154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant exhibits synthetic phenotype with alpha-synuclein","secondary_identifier":"SGD:S000002561","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR154C"}


id: YDR155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01246":null,"SJAG_01714":null,"YDR155C":null},"has_protein_features":false,"name":"CPR1","ortholog_annotations":[{"gene_uniquename":"YDR155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01246","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01714","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; N-terminally propionylated in vivo; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002562","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR155C"}


id: YDR156W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02653":null,"YDR156W":null},"has_protein_features":false,"name":"RPA14","ortholog_annotations":[{"gene_uniquename":"YDR156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02653","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase I subunit A14","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002563","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR156W"}


id: YDR157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000002564","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR157W"}


id: YDR158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00234":null,"YDR158W":null},"has_protein_features":false,"name":"HOM2","ortholog_annotations":[{"gene_uniquename":"YDR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00234","reference_uniquename":"PMID:29761456"}],"product":"Aspartic beta semi-aldehyde dehydrogenase; catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002565","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR158W"}


id: YDR159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04472":null,"SJAG_04656":null,"YDR159W":null},"has_protein_features":false,"name":"SAC3","ortholog_annotations":[{"gene_uniquename":"YDR159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04472","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04656","reference_uniquename":"PMID:29761456"}],"product":"mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR159W"}


id: YDR160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SSY1","product":"Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p","secondary_identifier":"SGD:S000002567","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR160W"}


id: YDR161W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04180":null,"YDR161W":null},"has_protein_features":false,"name":"ACL4","ortholog_annotations":[{"gene_uniquename":"YDR161W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04180","reference_uniquename":"PMID:29761456"}],"product":"Specific assembly chaperone for ribosomal protein Rpl4a/Rpl4b; associates co-translationally with a evolutionarily conserved internal loop of nascent Rpl4a/b, and is released only after an the eukaryotic-specific extension of nascent Rpl4a/b mediates nuclear import, incorporation into the pre-ribosome and complex disassembly; role in biogenesis of the 60S ribosomal subunit; transcriptionally co-regulated with rRNA and ribosome biosynthesis genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002568","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR161W"}


id: YDR162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04200":null,"YDR162C":null},"has_protein_features":false,"name":"NBP2","ortholog_annotations":[{"gene_uniquename":"YDR162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04200","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p to the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm; contains an SH3 domain and a Ptc1p binding domain (PBM)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002569","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR162C"}


id: YDR163W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00446":null,"YDR163W":null},"has_protein_features":false,"name":"CWC15","ortholog_annotations":[{"gene_uniquename":"YDR163W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00446","reference_uniquename":"PMID:29761456"}],"product":"Non-essential protein involved in pre-mRNA splicing; component of a complex containing Cef1p; has similarity to S. pombe Cwf15p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002570","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR163W"}


id: YDR164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01697":null,"YDR164C":null},"has_protein_features":false,"name":"SEC1","ortholog_annotations":[{"gene_uniquename":"YDR164C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01697","reference_uniquename":"PMID:29761456"}],"product":"Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function; interacts directly with essential exocyst subunit Sec6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002571","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR164C"}


id: YDR165W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04848":null,"YDR165W":null},"has_protein_features":false,"name":"TRM82","ortholog_annotations":[{"gene_uniquename":"YDR165W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04848","reference_uniquename":"PMID:29761456"}],"product":"Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p; relocalizes to the cytosol in response to hypoxia; mutation in human ortholog WDR4 causes microcephalic primordial dwarfism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002572","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR165W"}


id: YDR166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03938":null,"YDR166C":null},"has_protein_features":false,"name":"SEC5","ortholog_annotations":[{"gene_uniquename":"YDR166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03938","reference_uniquename":"PMID:29761456"}],"product":"Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002573","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR166C"}


id: YDR167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00584":null,"YDR167W":null},"has_protein_features":false,"name":"TAF10","ortholog_annotations":[{"gene_uniquename":"YDR167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00584","reference_uniquename":"PMID:29761456"}],"product":"Subunit (145 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002574","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR167W"}


id: YDR168W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04518":null,"YDR168W":null},"has_protein_features":false,"name":"CDC37","ortholog_annotations":[{"gene_uniquename":"YDR168W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04518","reference_uniquename":"PMID:29761456"}],"product":"Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002575","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR168W"}


id: YDR169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STB3","product":"Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000002576","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR169C"}


id: YDR169C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028538","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR169C-A"}


id: YDR170C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01025":null,"SJAG_02160":null,"YDR170C":null},"has_protein_features":false,"name":"SEC7","ortholog_annotations":[{"gene_uniquename":"YDR170C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01025","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR170C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02160","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors; involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002577","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR170C"}


id: YDR171W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02919":null,"SJAG_03815":null,"SJAG_04567":null,"YDR171W":null},"has_protein_features":false,"name":"HSP42","ortholog_annotations":[{"gene_uniquename":"YDR171W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02919","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR171W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03815","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR171W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04567","reference_uniquename":"PMID:29761456"}],"product":"Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002578","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR171W"}


id: YDR172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01696":null,"YDR172W":null},"has_protein_features":false,"name":"SUP35","ortholog_annotations":[{"gene_uniquename":"YDR172W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01696","reference_uniquename":"PMID:29761456"}],"product":"Translation termination factor eRF3; has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that modifies cellular fitness, alters translational fidelity by affecting reading frame selection, and results in a nonsense suppressor phenotype; many stress-response genes are repressed in the presence of [PSI(+)]","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002579","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR172W"}


id: YDR173C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03409":null,"YDR173C":null},"has_protein_features":false,"name":"ARG82","ortholog_annotations":[{"gene_uniquename":"YDR173C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03409","reference_uniquename":"PMID:29761456"}],"product":"Inositol polyphosphate multikinase (IPMK); sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates genes responsive to arginine, phosphate, and nitrogen; needed by most [PSI+] variants for prion propagation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002580","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR173C"}


id: YDR174W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01712":null,"YDR174W":null},"has_protein_features":false,"name":"HMO1","ortholog_annotations":[{"gene_uniquename":"YDR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01712","reference_uniquename":"PMID:29761456"}],"product":"Chromatin associated high mobility group (HMG) family member; involved in compacting, bending, bridging and looping DNA; rDNA-binding component that regulates transcription from RNA polymerase I promoters; regulates start site selection of ribosomal protein genes via RNA polymerase II promoters; role in genome maintenance; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002581","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR174W"}


id: YDR175C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01520":null,"YDR175C":null},"has_protein_features":false,"name":"RSM24","ortholog_annotations":[{"gene_uniquename":"YDR175C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01520","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002582","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR175C"}


id: YDR176W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01711":null,"YDR176W":null},"has_protein_features":false,"name":"NGG1","ortholog_annotations":[{"gene_uniquename":"YDR176W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01711","reference_uniquename":"PMID:29761456"}],"product":"Subunit of chromatin modifying histone acetyltransferase complexes; member of the ADA complex, the SAGA complex, and the SLIK complex; transcriptional regulator involved in glucose repression of Gal4p-regulated genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002583","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR176W"}


id: YDR177W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00931":null,"YDR177W":null},"has_protein_features":false,"name":"UBC1","ortholog_annotations":[{"gene_uniquename":"YDR177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00931","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-conjugating enzyme; key E2 partner with Ubc4p for the anaphase-promoting complex (APC); mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress key E2 partner with Ubc4p for the anaphase-promoting complex (APC)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002584","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR177W"}


id: YDR178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02398":null,"YDR178W":null},"has_protein_features":false,"name":"SDH4","ortholog_annotations":[{"gene_uniquename":"YDR178W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02398","reference_uniquename":"PMID:29761456"}],"product":"Membrane anchor subunit of succinate dehydrogenase (SDH); involved in coupling the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; has similarity to human SDH subunit D (SDHD), which is implicated in paraganglioma","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002585","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR178W"}


id: YDR179C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02764":null,"YDR179C":null},"has_protein_features":false,"name":"CSN9","ortholog_annotations":[{"gene_uniquename":"YDR179C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02764","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Cop9 signalosome; Cop9 signalosome is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002586","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR179C"}


id: YDR179W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NVJ3","product":"Protein with a potential role in tethering ER and vacuoles; localizes to nucleus-vacuole junctions in an Mdm1p-dependent manner; contains a lipid-binding PXA domain","secondary_identifier":"SGD:S000002587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR179W-A"}


id: YDR180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00796":null,"YDR180W":null},"has_protein_features":false,"name":"SCC2","ortholog_annotations":[{"gene_uniquename":"YDR180W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00796","reference_uniquename":"PMID:29761456"}],"product":"Subunit of cohesin loading factor (Scc2p-Scc4p); a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; promotes gene expression program that supports translational fidelity; evolutionarily-conserved adherin; relocalizes to cytosol in response to hypoxia; human disorder Cornelia de Lange syndrome is caused by mutations in NIPBL, the human ortholog of SCC2; conserved role in NHEJ","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002588","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR180W"}


id: YDR181C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SAS4","product":"Subunit of the SAS complex (Sas2p, Sas4p, Sas5p); acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p","secondary_identifier":"SGD:S000002589","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR181C"}


id: YDR182W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04924":null,"YDR182W":null},"has_protein_features":false,"name":"CDC1","ortholog_annotations":[{"gene_uniquename":"YDR182W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04924","reference_uniquename":"PMID:29761456"}],"product":"Putative mannose-ethanolamine phosphate phosphodiesterase; involved in GPI-anchor remodeling prior to the attachment of cell wall proteins to beta 1,3-glucan, removing ethanolamine phosphate from the first mannose of GPI anchors; mutants display elevated Ca2+-dependent signaling resulting in secondary actin polarization and Golgi inheritance defects; enzyme is Mn2+-dependent; mutants have cell division cycle defect and fragile cell walls","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002590","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR182W"}


id: YDR182W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028539","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR182W-A"}


id: YDR183C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028540","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR183C-A"}


id: YDR183W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PLP1","product":"Protein that interacts with CCT (chaperonin containing TCP-1) complex; has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators","secondary_identifier":"SGD:S000002591","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR183W"}


id: YDR184C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATC1","product":"Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress","secondary_identifier":"SGD:S000002592","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR184C"}


id: YDR185C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00576":null,"YDR185C":null},"has_protein_features":false,"name":"UPS3","ortholog_annotations":[{"gene_uniquename":"YDR185C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00576","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations; UPS3 has a paralog, UPS2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002593","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR185C"}


id: YDR186C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SND1","product":"Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Env10p/Snd2p and Pho88p/Snd3p; can compensate for loss of SRP; co-purifies with ribosomes; GFP-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000002594","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR186C"}


id: YDR187C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W","secondary_identifier":"SGD:S000002595","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR187C"}


id: YDR188W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02378":null,"YDR188W":null},"has_protein_features":false,"name":"CCT6","ortholog_annotations":[{"gene_uniquename":"YDR188W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02378","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002596","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR188W"}


id: YDR189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03499":null,"YDR189W":null},"has_protein_features":false,"name":"SLY1","ortholog_annotations":[{"gene_uniquename":"YDR189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03499","reference_uniquename":"PMID:29761456"}],"product":"Hydrophilic protein involved in ER/Golgi vesicle trafficking; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002597","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR189W"}


id: YDR190C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04355":null,"YDR190C":null},"has_protein_features":false,"name":"RVB1","ortholog_annotations":[{"gene_uniquename":"YDR190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04355","reference_uniquename":"PMID:29761456"}],"product":"ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002598","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR190C"}


id: YDR191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04039":null,"YDR191W":null},"has_protein_features":false,"name":"HST4","ortholog_annotations":[{"gene_uniquename":"YDR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04039","reference_uniquename":"PMID:29761456"}],"product":"NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; accumulates in mitochondria in response to biotin starvation and may link biotin metabolism with energy homeostasis; member of the Sir2 family and may be the functional equivalent of human SIRT3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002599","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR191W"}


id: YDR192C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01013":null,"SJAG_03103":null,"YDR192C":null},"has_protein_features":false,"name":"NUP42","ortholog_annotations":[{"gene_uniquename":"YDR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01013","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03103","reference_uniquename":"PMID:26896847"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p; human homolog NUP42 can complement yeast mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002600","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR192C"}


id: YDR193W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002601","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR193W"}


id: YDR194C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MSS116","product":"Mitochondrial transcription elongation factor; DEAD-box protein; required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing; promotes RNA folding by stabilizing an early assembly intermediate","secondary_identifier":"SGD:S000002602","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR194C"}


id: YDR194W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028541","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR194W-A"}


id: YDR195W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"REF2","product":"RNA-binding protein; involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes; putative regulatory subunit of type 1 protein phosphatase Glc7p, required for actomyosin ring formation, and for timely dephosphorylation and release of Bnr1p from the division site; relocalizes to the cytosol in response to hypoxia","secondary_identifier":"SGD:S000002603","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR195W"}


id: YDR196C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04288":null,"YDR196C":null},"has_protein_features":false,"name":"CAB5","ortholog_annotations":[{"gene_uniquename":"YDR196C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04288","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; involved in histone acylation; null mutant lethality is complemented by human homolog DCAKD and by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies; also localized to lipid droplets","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002604","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR196C"}


id: YDR197W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CBS2","product":"Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader","secondary_identifier":"SGD:S000002605","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR197W"}


id: YDR198C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01193":null,"YDR198C":null},"has_protein_features":false,"name":"RKM2","ortholog_annotations":[{"gene_uniquename":"YDR198C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01193","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein lysine methyltransferase; responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002606","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR198C"}


id: YDR199W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64/YDR200C; computationally predicted to have thiol-disulfide oxidoreductase activity","secondary_identifier":"SGD:S000002607","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR199W"}


id: YDR200C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04455":null,"YDR200C":null},"has_protein_features":false,"name":"VPS64","ortholog_annotations":[{"gene_uniquename":"YDR200C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04455","reference_uniquename":"PMID:29761456"}],"product":"Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance; VPS64 has a paralog, FAR10, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR200C"}


id: YDR201W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05220":null,"YDR201W":null},"has_protein_features":false,"name":"SPC19","ortholog_annotations":[{"gene_uniquename":"YDR201W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05220","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR201W"}


id: YDR202C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04454":null,"YDR202C":null},"has_protein_features":false,"name":"RAV2","ortholog_annotations":[{"gene_uniquename":"YDR202C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04454","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RAVE complex (Rav1p, Rav2p, Skp1p); the RAVE complex associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002610","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR202C"}


id: YDR203W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF RAV2/YDR202C","secondary_identifier":"SGD:S000002611","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR203W"}


id: YDR204W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00721":null,"YDR204W":null},"has_protein_features":false,"name":"COQ4","ortholog_annotations":[{"gene_uniquename":"YDR204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00721","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in ubiquinone (Coenzyme Q) biosynthesis; possibly functioning in stabilization of Coq7p; located on matrix face of mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex; human homolog COQ4 can complement yeast coq4 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002612","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR204W"}


id: YDR205W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00328":null,"YDR205W":null},"has_protein_features":false,"name":"MSC2","ortholog_annotations":[{"gene_uniquename":"YDR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00328","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR205W"}


id: YDR206W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00939":null,"YDR206W":null},"has_protein_features":false,"name":"EBS1","ortholog_annotations":[{"gene_uniquename":"YDR206W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00939","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in translation inhibition and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors; EBS1 has a paralog, EST1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002614","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR206W"}


id: YDR207C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UME6","product":"Rpd3L histone deacetylase complex subunit; key transcriptional regulator of early meiotic genes; involved in chromatin remodeling and transcriptional repression via DNA looping; binds URS1 upstream regulatory sequence, represses transcription by recruiting conserved histone deacetylase Rpd3p (through co-repressor Sin3p) and chromatin-remodeling factor Isw2p; couples metabolic responses to nutritional cues with initiation and progression of meiosis","secondary_identifier":"SGD:S000002615","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR207C"}


id: YDR208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01863":null,"YDR208W":null},"has_protein_features":false,"name":"MSS4","ortholog_annotations":[{"gene_uniquename":"YDR208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01863","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002616","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR208W"}


id: YDR209C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YDR209C is not an essential gene; partially overlaps uncharacterized gene YDR210W","secondary_identifier":"SGD:S000002617","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR209C"}


id: YDR210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02333":null,"YDR210W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02333","reference_uniquename":"PMID:29761456"}],"product":"Predicted tail-anchored plasma membrane protein; contains a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002618","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR210W"}


id: YDR211W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02471":null,"YDR211W":null},"has_protein_features":false,"name":"GCD6","ortholog_annotations":[{"gene_uniquename":"YDR211W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02471","reference_uniquename":"PMID:29761456"}],"product":"Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; mutations in human ortholog cause fatal brain disease childhood ataxia with central nervous system hypomyelination (CACH); forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR211W"}


id: YDR212W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00609":null,"YDR212W":null},"has_protein_features":false,"name":"TCP1","ortholog_annotations":[{"gene_uniquename":"YDR212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00609","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of chaperonin-containing T-complex; complex mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002620","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR212W"}


id: YDR213W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UPC2","product":"Sterol regulatory element binding protein; induces sterol biosynthetic genes, upon sterol depletion; acts as a sterol sensor, binding ergosterol in sterol rich conditions; relocates from intracellular membranes to perinuclear foci upon sterol depletion; redundant activator of filamentation with ECM22, up-regulating the expression of filamentous growth genes; contains a Zn[2]-Cys[6] binuclear cluster; UPC2 has a paralog, ECM22, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002621","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR213W"}


id: YDR214W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01121":null,"YDR214W":null},"has_protein_features":false,"name":"AHA1","ortholog_annotations":[{"gene_uniquename":"YDR214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01121","reference_uniquename":"PMID:29761456"}],"product":"Co-chaperone that binds Hsp82p and activates its ATPase activity; plays a role in determining prion variants; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002622","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR214W"}


id: YDR215C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein","secondary_identifier":"SGD:S000002623","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR215C"}


id: YDR216W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03346":null,"YDR216W":null},"has_protein_features":false,"name":"ADR1","ortholog_annotations":[{"gene_uniquename":"YDR216W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03346","reference_uniquename":"PMID:29761456"}],"product":"Carbon source-responsive zinc-finger transcription factor; required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002624","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR216W"}


id: YDR217C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01205":null,"YDR217C":null},"has_protein_features":false,"name":"RAD9","ortholog_annotations":[{"gene_uniquename":"YDR217C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01205","reference_uniquename":"PMID:29761456"}],"product":"DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M, plays a role in postreplication repair (PRR) pathway; transmits checkpoint signal by activating Rad53p and Chk1p; protects double-strand breaks from premature resection; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; Rad9p Chk1 Activating Domain (CAD) is phosphorylated at multiple sites by Cdc28p/Clb2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002625","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR217C"}


id: YDR218C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01769":null,"YDR218C":null},"has_protein_features":false,"name":"SPR28","ortholog_annotations":[{"gene_uniquename":"YDR218C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01769","reference_uniquename":"PMID:26896847"}],"product":"Sporulation-specific homolog of the CDC3/10/11/12 family of genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation; the yeast CDC3/10/11/12 family is a family of bud neck microfilament genes","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000002626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR218C"}


id: YDR219C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MFB1","product":"Mitochondria-associated F-box protein; involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding","secondary_identifier":"SGD:S000002627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR219C"}


id: YDR220C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant exhibits synthetic phenotype with alpha-synuclein","secondary_identifier":"SGD:S000002628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR220C"}


id: YDR221W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03535":null,"YDR221W":null},"has_protein_features":false,"name":"GTB1","ortholog_annotations":[{"gene_uniquename":"YDR221W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03535","reference_uniquename":"PMID:29761456"}],"product":"Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR221W"}


id: YDR222W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YDR222W has a paralog, YLR225C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR222W"}


id: YDR223W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02671":null,"YDR223W":null},"has_protein_features":false,"name":"CRF1","ortholog_annotations":[{"gene_uniquename":"YDR223W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02671","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional corepressor; involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain; CRF1 has a paralog, IFH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR223W"}


id: YDR224C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03941":null,"YDR224C":null},"has_protein_features":false,"name":"HTB1","ortholog_annotations":[{"gene_uniquename":"YDR224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03941","reference_uniquename":"PMID:29761456"}],"product":"Histone H2B; core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates reassembly after DNA replication, transcriptional activation, meiotic DSB formation and H3 methylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR224C"}


id: YDR225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01873":null,"SJAG_03942":null,"YDR225W":null},"has_protein_features":false,"name":"HTA1","ortholog_annotations":[{"gene_uniquename":"YDR225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01873","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03942","reference_uniquename":"PMID:29761456"}],"product":"Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; N-terminally propionylated in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002633","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR225W"}


id: YDR226W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02038":null,"YDR226W":null},"has_protein_features":false,"name":"ADK1","ortholog_annotations":[{"gene_uniquename":"YDR226W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02038","reference_uniquename":"PMID:29761456"}],"product":"Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress; mutations affecting Adk1p catalytic activity deregulate expression of phosphate utilization genes PHO5 and PHO84; human homolog AK1 can complement yeast adk1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002634","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR226W"}


id: YDR227W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SIR4","product":"SIR protein involved in assembly of silent chromatin domains; silent information regulator (SIR) along with SIR2 and SIR3; involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; some SIR4 alleles prolong lifespan; required for Ku-mediated telomerase recruitment, telomere lengthening, and telomere hypercluster formation in quiescent yeast cells","secondary_identifier":"SGD:S000002635","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR227W"}


id: YDR228C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02037":null,"YDR228C":null},"has_protein_features":false,"name":"PCF11","ortholog_annotations":[{"gene_uniquename":"YDR228C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02037","reference_uniquename":"PMID:29761456"}],"product":"mRNA 3' end processing factor; essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002636","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR228C"}


id: YDR229W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IVY1","product":"Phospholipid-binding protein that interacts with both Ypt7p and Vps33p; may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase; contains a putative inverse BAR (I-BAR) domain that can mold lipid bilayer membranes into protrusions","secondary_identifier":"SGD:S000002637","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR229W"}


id: YDR230W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20/YDR231C","secondary_identifier":"SGD:S000002638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR230W"}


id: YDR231C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06046":null,"YDR231C":null},"has_protein_features":false,"name":"COX20","ortholog_annotations":[{"gene_uniquename":"YDR231C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06046","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein; required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002639","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR231C"}


id: YDR232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03961":null,"YDR232W":null},"has_protein_features":false,"name":"HEM1","ortholog_annotations":[{"gene_uniquename":"YDR232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03961","reference_uniquename":"PMID:29761456"}],"product":"5-aminolevulinate synthase; catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p; has a pyridoxal phosphate cofactor whose insertion is mediated by Mcx1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002640","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR232W"}


id: YDR233C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01848":null,"YDR233C":null},"has_protein_features":false,"name":"RTN1","ortholog_annotations":[{"gene_uniquename":"YDR233C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01848","reference_uniquename":"PMID:29761456"}],"product":"Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; increases tubular ER when overexpressed; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; member of the RTNLA subfamily","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002641","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR233C"}


id: YDR234W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01574":null,"YDR234W":null},"has_protein_features":false,"name":"LYS4","ortholog_annotations":[{"gene_uniquename":"YDR234W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01574","reference_uniquename":"PMID:29761456"}],"product":"Homoaconitase; catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR234W"}


id: YDR235W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00058":null,"YDR235W":null},"has_protein_features":false,"name":"PRP42","ortholog_annotations":[{"gene_uniquename":"YDR235W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00058","reference_uniquename":"PMID:29761456"}],"product":"U1 snRNP protein involved in splicing; required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR235W"}


id: YDR236C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04845":null,"YDR236C":null},"has_protein_features":false,"name":"FMN1","ortholog_annotations":[{"gene_uniquename":"YDR236C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04845","reference_uniquename":"PMID:29761456"}],"product":"Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane; human RFK functionally complements the lethality of the null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR236C"}


id: YDR237W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01719":null,"YDR237W":null},"has_protein_features":false,"name":"MRPL7","ortholog_annotations":[{"gene_uniquename":"YDR237W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01719","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR237W"}


id: YDR238C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04002":null,"YDR238C":null},"has_protein_features":false,"name":"SEC26","ortholog_annotations":[{"gene_uniquename":"YDR238C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04002","reference_uniquename":"PMID:29761456"}],"product":"Essential beta-coat protein of the COPI coatomer; involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR238C"}


id: YDR239C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments","secondary_identifier":"SGD:S000002647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR239C"}


id: YDR240C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SNU56","product":"Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex","secondary_identifier":"SGD:S000002648","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR240C"}


id: YDR241W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUD26","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay","secondary_identifier":"SGD:S000002649","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR241W"}


id: YDR242W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AMD2","product":"Putative amidase","secondary_identifier":"SGD:S000002650","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR242W"}


id: YDR243C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04230":null,"YDR243C":null},"has_protein_features":false,"name":"PRP28","ortholog_annotations":[{"gene_uniquename":"YDR243C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04230","reference_uniquename":"PMID:29761456"}],"product":"Pre-mRNA splicing factor; RNA binding protein involved in RNA isomerization at the 5' splice site and for exchange of U6 for U1 snRNA at the 5' splice site; similar to the RNA helicases of the DEAD-box family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR243C"}


id: YDR244W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00702":null,"YDR244W":null},"has_protein_features":false,"name":"PEX5","ortholog_annotations":[{"gene_uniquename":"YDR244W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00702","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal membrane signal receptor for peroxisomal matrix proteins; receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins; required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR244W"}


id: YDR245W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01972":null,"SJAG_02996":null,"SJAG_03555":null,"SJAG_03790":null,"SJAG_03871":null,"SJAG_04095":null,"SJAG_04401":null,"YDR245W":null},"has_protein_features":false,"name":"MNN10","ortholog_annotations":[{"gene_uniquename":"YDR245W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01972","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR245W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02996","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR245W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03555","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR245W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03790","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR245W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03871","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR245W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04095","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR245W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04401","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a Golgi mannosyltransferase complex; complex mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family; other members of the complex are Anp1p, Mnn9p, Mnn11p, and Hoc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002653","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR245W"}


id: YDR246W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04021":null,"YDR246W":null},"has_protein_features":false,"name":"TRS23","ortholog_annotations":[{"gene_uniquename":"YDR246W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04021","reference_uniquename":"PMID:29761456"}],"product":"Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); human homolog is TRAPPC4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002654","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR246W"}


id: YDR246W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028542","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR246W-A"}


id: YDR247W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01311":null,"YDR247W":null},"has_protein_features":false,"name":"VHS1","ortholog_annotations":[{"gene_uniquename":"YDR247W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01311","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; VHS1 has a paralog, SKS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR247W"}


id: YDR248C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00633":null,"YDR248C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR248C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00633","reference_uniquename":"PMID:29761456"}],"product":"Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR248C"}


id: YDR249C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000002657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR249C"}


id: YDR250C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR250C"}


id: YDR251W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02729":null,"SJAG_04591":null,"YDR251W":null},"has_protein_features":false,"name":"PAM1","ortholog_annotations":[{"gene_uniquename":"YDR251W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02729","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR251W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04591","reference_uniquename":"PMID:29761456"}],"product":"Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype; PAM1 has a paralog, SVL3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR251W"}


id: YDR252W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01733":null,"YDR252W":null},"has_protein_features":false,"name":"BTT1","ortholog_annotations":[{"gene_uniquename":"YDR252W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01733","reference_uniquename":"PMID:29761456"}],"product":"Heterotrimeric nascent polypeptide-associated complex beta3 subunit; complex binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3; BTT1 has a paralog, EGD1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR252W"}


id: YDR253C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MET32","product":"Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; feedforward loop exists in the regulation of genes controlled by Met4p and Met32p; lack of such a loop for MET31 may account for the differential actions of Met32p and Met31p; MET32 has a paralog, MET31, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR253C"}


id: YDR254W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04696":null,"YDR254W":null},"has_protein_features":false,"name":"CHL4","ortholog_annotations":[{"gene_uniquename":"YDR254W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04696","reference_uniquename":"PMID:29761456"}],"product":"Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; forms a stable complex with Iml3p; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, and Mif2p; required for the spindle assembly checkpoint; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR254W"}


id: YDR255C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01637":null,"YDR255C":null},"has_protein_features":false,"name":"RMD5","ortholog_annotations":[{"gene_uniquename":"YDR255C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01637","reference_uniquename":"PMID:29761456"}],"product":"Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002663","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR255C"}


id: YDR256C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04823":null,"YDR256C":null},"has_protein_features":false,"name":"CTA1","ortholog_annotations":[{"gene_uniquename":"YDR256C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04823","reference_uniquename":"PMID:29761456"}],"product":"Catalase A; breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002664","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR256C"}


id: YDR257C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01482":null,"SJAG_03869":null,"YDR257C":null},"has_protein_features":false,"name":"RKM4","ortholog_annotations":[{"gene_uniquename":"YDR257C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01482","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR257C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03869","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002665","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR257C"}


id: YDR258C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02825":null,"YDR258C":null},"has_protein_features":false,"name":"HSP78","ortholog_annotations":[{"gene_uniquename":"YDR258C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02825","reference_uniquename":"PMID:29761456"}],"product":"Oligomeric mitochondrial matrix chaperone; cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002666","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR258C"}


id: YDR259C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YAP6","product":"Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002667","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR259C"}


id: YDR260C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04520":null,"YDR260C":null},"has_protein_features":false,"name":"SWM1","ortholog_annotations":[{"gene_uniquename":"YDR260C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04520","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the anaphase-promoting complex (APC); APC is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002668","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR260C"}


id: YDR261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01171":null,"SJAG_01888":null,"SJAG_05001":null,"YDR261C":null},"has_protein_features":false,"name":"EXG2","ortholog_annotations":[{"gene_uniquename":"YDR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01171","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01888","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05001","reference_uniquename":"PMID:29761456"}],"product":"Exo-1,3-beta-glucanase; involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR261C"}


id: YDR262W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03998":null,"YDR262W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR262W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03998","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002670","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR262W"}


id: YDR263C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01832":null,"YDR263C":null},"has_protein_features":false,"name":"DIN7","ortholog_annotations":[{"gene_uniquename":"YDR263C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01832","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial nuclease functioning in DNA repair and replication; modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination; DIN7 has a paralog, EXO1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR263C"}


id: YDR264C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01112":null,"YDR264C":null},"has_protein_features":false,"name":"AKR1","ortholog_annotations":[{"gene_uniquename":"YDR264C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01112","reference_uniquename":"PMID:29761456"}],"product":"Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication; any of several human homologs encoding DHHC-type zinc fingers (ZDHHC) can complement temperature sensitivity of yeast akr1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR264C"}


id: YDR265W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01165":null,"YDR265W":null},"has_protein_features":false,"name":"PEX10","ortholog_annotations":[{"gene_uniquename":"YDR265W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01165","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal membrane E3 ubiquitin ligase; required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR265W"}


id: YDR266C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02746":null,"YDR266C":null},"has_protein_features":false,"name":"HEL2","ortholog_annotations":[{"gene_uniquename":"YDR266C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02746","reference_uniquename":"PMID:29761456"}],"product":"RING finger ubiquitin ligase (E3); subunit of ribosome-associated quality control trigger complex (RQT); involved in ubiquitination and degradation of excess histones; interacts with Ubc4p and Rad53p; required to trigger ribosome-associated quality control (RQC) and canonical no-go decay; ubiquitinates Rps20 and Rps3; binds to ribosomal RNA, mRNA and tRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002674","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR266C"}


id: YDR267C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02895":null,"YDR267C":null},"has_protein_features":false,"name":"CIA1","ortholog_annotations":[{"gene_uniquename":"YDR267C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02895","reference_uniquename":"PMID:29761456"}],"product":"Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at late step of Fe-S cluster assembly; forms CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation and maturation of a subset of cytosolic and nuclear proteins involved in methionine biosynthesis, DNA replication and repair, transcription and telomere maintenance; contains WD40 repeats; human homolog CIAO1 complements the yeast cia1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002675","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR267C"}


id: YDR268W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04840":null,"YDR268W":null},"has_protein_features":false,"name":"MSW1","ortholog_annotations":[{"gene_uniquename":"YDR268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04840","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial tryptophanyl-tRNA synthetase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR268W"}


id: YDR269C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR269C"}


id: YDR270W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02399":null,"YDR270W":null},"has_protein_features":false,"name":"CCC2","ortholog_annotations":[{"gene_uniquename":"YDR270W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02399","reference_uniquename":"PMID:29761456"}],"product":"Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; similar to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism; human homologs ATP7A and ATP7B both complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR270W"}


id: YDR271C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W","secondary_identifier":"SGD:S000002679","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR271C"}


id: YDR272W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01596":null,"YDR272W":null},"has_protein_features":false,"name":"GLO2","ortholog_annotations":[{"gene_uniquename":"YDR272W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01596","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO2 has a paralog, GLO4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002680","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR272W"}


id: YDR273W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05335":null,"YDR273W":null},"has_protein_features":false,"name":"DON1","ortholog_annotations":[{"gene_uniquename":"YDR273W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05335","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific component of the spindle pole body; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane (PSM) during meiosis II; required for PSM growth and closure; DON1 has a paralog, CUE5, that arose from the whole genome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002681","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR273W"}


id: YDR274C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YDR274C is not an essential gene","secondary_identifier":"SGD:S000002682","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR274C"}


id: YDR275W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BSC2","product":"Protein of unknown function involved in multidrug resistance; inhibits oxidative damage induced by amphotericin B; overexpression increases flocculation, biofilm formation, invasive and pseudohyphal growth; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; null mutant displays increased translation rate and increased readthrough of premature stop codons; BSC2 has a paralog, IRC23, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002683","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR275W"}


id: YDR276C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00372":null,"YDR276C":null},"has_protein_features":false,"name":"PMP3","ortholog_annotations":[{"gene_uniquename":"YDR276C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00372","reference_uniquename":"PMID:29761456"}],"product":"Small plasma membrane protein; confers resistance to amphotericin B and is a potential target of this common antifungal drug; related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature; not essential for viability; deletion causes hyperpolarization of the plasma membrane potential","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR276C"}


id: YDR277C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MTH1","product":"Negative regulator of the glucose-sensing signal transduction pathway; required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation; MTH1 has a paralog, STD1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002685","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR277C"}


id: YDR278C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YDR278C is not an essential gene","secondary_identifier":"SGD:S000002686","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR278C"}


id: YDR279W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00400":null,"YDR279W":null},"has_protein_features":false,"name":"RNH202","ortholog_annotations":[{"gene_uniquename":"YDR279W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00400","reference_uniquename":"PMID:29761456"}],"product":"Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS2 that causes Aicardi-Goutieres syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002687","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR279W"}


id: YDR280W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04824":null,"YDR280W":null},"has_protein_features":false,"name":"RRP45","ortholog_annotations":[{"gene_uniquename":"YDR280W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04824","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002688","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR280W"}


id: YDR281C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PHM6","product":"Protein of unknown function; expression is regulated by phosphate levels","secondary_identifier":"SGD:S000002689","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR281C"}


id: YDR282C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01174":null,"SJAG_02548":null,"YDR282C":null},"has_protein_features":false,"name":"MRX10","ortholog_annotations":[{"gene_uniquename":"YDR282C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01174","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR282C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02548","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein of unknown function; associates with mitochondrial ribosome; localizes to the inner membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002690","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR282C"}


id: YDR283C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00169":null,"YDR283C":null},"has_protein_features":false,"name":"GCN2","ortholog_annotations":[{"gene_uniquename":"YDR283C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00169","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002691","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR283C"}


id: YDR284C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02356":null,"YDR284C":null},"has_protein_features":false,"name":"DPP1","ortholog_annotations":[{"gene_uniquename":"YDR284C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02356","reference_uniquename":"PMID:29761456"}],"product":"Diacylglycerol pyrophosphate (DGPP) phosphatase; zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002692","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR284C"}


id: YDR285W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ZIP1","product":"Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; required for meiotic recombination between non-allelc sites; potential Cdc28p substrate","secondary_identifier":"SGD:S000002693","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR285W"}


id: YDR286C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MGP12","product":"Mitochondrial protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site","secondary_identifier":"SGD:S000002694","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR286C"}


id: YDR287W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"INM2","product":"Inositol monophosphatase; involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy","secondary_identifier":"SGD:S000002695","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR287W"}


id: YDR288W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03702":null,"YDR288W":null},"has_protein_features":false,"name":"NSE3","ortholog_annotations":[{"gene_uniquename":"YDR288W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03702","reference_uniquename":"PMID:29761456"}],"product":"Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002696","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR288W"}


id: YDR289C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00448":null,"YDR289C":null},"has_protein_features":false,"name":"RTT103","ortholog_annotations":[{"gene_uniquename":"YDR289C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00448","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in transcription termination by RNA polymerase II; interacts with exonuclease Rat1p and Rai1p; has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002697","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR289C"}


id: YDR290W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103","secondary_identifier":"SGD:S000002698","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR290W"}


id: YDR291W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02200":null,"YDR291W":null},"has_protein_features":false,"name":"HRQ1","ortholog_annotations":[{"gene_uniquename":"YDR291W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02200","reference_uniquename":"PMID:29761456"}],"product":"3'-5' DNA helicase of the conserved RecQ family; involved in Pso2p-mediated interstrand crosslink repair; acts with Rad4p in nucleotide-excision repair; binds telomeres, modulates telomerase activity with Pif1p and inhibits telomere addition to dsDNA breaks; role in telomerase-independent telomere maintenance; lacks ssDNA annealing and strand exchange activities; human RecQL4, a structural and functional homolog, is involved in Rothmund-Thomson, Baller-Gerold and RAPADILINO syndromes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002699","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR291W"}


id: YDR292C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01558":null,"YDR292C":null},"has_protein_features":false,"name":"SRP101","ortholog_annotations":[{"gene_uniquename":"YDR292C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01558","reference_uniquename":"PMID:29761456"}],"product":"Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002700","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR292C"}


id: YDR293C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01822":null,"SJAG_03132":null,"YDR293C":null},"has_protein_features":false,"name":"SSD1","ortholog_annotations":[{"gene_uniquename":"YDR293C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01822","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR293C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03132","reference_uniquename":"PMID:29761456"}],"product":"Translational repressor;  involved in polar growth, wall integrity, autodiploidization; regulated by Cbk1p phosphorylation to affect bud-specific translational control and localization of specific mRNAs; binds 5'UTRs of mRNAs encoding cell wall proteins; recognizes CNYTCNYT motif in RNA; interacts with TOR pathway components; nucleocytoplasmic shuttling appears to be critical to Ssd1p function; W303 lacks a functional SSD1 gene product; pseudonuclease descended from Dis3L2-family nucleases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002701","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR293C"}


id: YDR294C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DPL1","product":"Dihydrosphingosine phosphate lyase; regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate","secondary_identifier":"SGD:S000002702","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR294C"}


id: YDR295C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03685":null,"YDR295C":null},"has_protein_features":false,"name":"HDA2","ortholog_annotations":[{"gene_uniquename":"YDR295C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03685","reference_uniquename":"PMID:29761456"}],"product":"Subunit of HDA1 histone deacetylase complex; tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance; Hda2p relocalizes to cytosol in response to hypoxia; other members of the HDA1 histone deacetylase complex, which regulates aging through trehalose metabolism, are Hda1p and Hda3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002703","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR295C"}


id: YDR296W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03402":null,"YDR296W":null},"has_protein_features":false,"name":"MHR1","ortholog_annotations":[{"gene_uniquename":"YDR296W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03402","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; also involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR296W"}


id: YDR297W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05311":null,"YDR297W":null},"has_protein_features":false,"name":"SUR2","ortholog_annotations":[{"gene_uniquename":"YDR297W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05311","reference_uniquename":"PMID:29761456"}],"product":"Sphinganine C4-hydroxylase; catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002705","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR297W"}


id: YDR298C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00133":null,"YDR298C":null},"has_protein_features":false,"name":"ATP5","ortholog_annotations":[{"gene_uniquename":"YDR298C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00133","reference_uniquename":"PMID:29761456"}],"product":"Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002706","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR298C"}


id: YDR299W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01604":null,"YDR299W":null},"has_protein_features":false,"name":"BFR2","ortholog_annotations":[{"gene_uniquename":"YDR299W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01604","reference_uniquename":"PMID:29761456"}],"product":"Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002707","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR299W"}


id: YDR300C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03457":null,"YDR300C":null},"has_protein_features":false,"name":"PRO1","ortholog_annotations":[{"gene_uniquename":"YDR300C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03457","reference_uniquename":"PMID:29761456"}],"product":"Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002708","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR300C"}


id: YDR301W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03233":null,"YDR301W":null},"has_protein_features":false,"name":"CFT1","ortholog_annotations":[{"gene_uniquename":"YDR301W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03233","reference_uniquename":"PMID:29761456"}],"product":"RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002709","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR301W"}


id: YDR302W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02488":null,"YDR302W":null},"has_protein_features":false,"name":"GPI11","ortholog_annotations":[{"gene_uniquename":"YDR302W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02488","reference_uniquename":"PMID:29761456"}],"product":"ER membrane protein involved in a late step of GPI anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated glycosylphosphatidylinositol (GPI) intermediate; human PIG-Fp is a functional homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002710","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR302W"}


id: YDR303C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RSC3","product":"Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; RSC3 has a paralog, RSC30, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002711","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR303C"}


id: YDR304C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02413":null,"YDR304C":null},"has_protein_features":false,"name":"CPR5","ortholog_annotations":[{"gene_uniquename":"YDR304C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02413","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the ER; catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER; CPR5 has a paralog, CPR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002712","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR304C"}


id: YDR305C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04169":null,"YDR305C":null},"has_protein_features":false,"name":"HNT2","ortholog_annotations":[{"gene_uniquename":"YDR305C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04169","reference_uniquename":"PMID:29761456"}],"product":"Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002713","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR305C"}


id: YDR306C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01392":null,"YDR306C":null},"has_protein_features":false,"name":"PFU1","ortholog_annotations":[{"gene_uniquename":"YDR306C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01392","reference_uniquename":"PMID:29761456"}],"product":"F-box protein that regulates pheromone-dependent morphogenesis; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002714","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR306C"}


id: YDR307W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01491":null,"YDR307W":null},"has_protein_features":false,"name":"PMT7","ortholog_annotations":[{"gene_uniquename":"YDR307W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01491","reference_uniquename":"PMID:26896847"}],"product":"Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000002715","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR307W"}


id: YDR308C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05203":null,"YDR308C":null},"has_protein_features":false,"name":"SRB7","ortholog_annotations":[{"gene_uniquename":"YDR308C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05203","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002716","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR308C"}


id: YDR309C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GIC2","product":"Rho-family GTPase interacting protein and Cdc42p effector; required with Gic1p for cell polarity establishment and initiation of budding; involved in recruitment of septins to the presumptive bud site; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region; gic1 gic2 double mutants are defective for polarizing Cdc42p at elevated temperature, so may function both up- and downstream of Cdc42p; regulates mitotic exit","secondary_identifier":"SGD:S000002717","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR309C"}


id: YDR310C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SUM1","product":"Transcriptional repressor that regulates middle-sporulation genes; required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint","secondary_identifier":"SGD:S000002718","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR310C"}


id: YDR311W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00512":null,"YDR311W":null},"has_protein_features":false,"name":"TFB1","ortholog_annotations":[{"gene_uniquename":"YDR311W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00512","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TFIIH and nucleotide excision repair factor 3 complexes; required for nucleotide excision repair, target for transcriptional activators; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002719","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR311W"}


id: YDR312W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02427":null,"YDR312W":null},"has_protein_features":false,"name":"SSF2","ortholog_annotations":[{"gene_uniquename":"YDR312W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02427","reference_uniquename":"PMID:29761456"}],"product":"Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002720","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR312W"}


id: YDR313C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00173":null,"YDR313C":null},"has_protein_features":false,"name":"PIB1","ortholog_annotations":[{"gene_uniquename":"YDR313C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00173","reference_uniquename":"PMID:29761456"}],"product":"RING-type ubiquitin ligase of the endosomal and vacuolar membranes; binds phosphatidylinositol 3-phosphate; contains a FYVE finger domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002721","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR313C"}


id: YDR314C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01049":null,"SJAG_01887":null,"YDR314C":null},"has_protein_features":false,"name":"RAD34","ortholog_annotations":[{"gene_uniquename":"YDR314C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01049","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR314C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01887","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in nucleotide excision repair (NER); homologous to RAD4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002722","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR314C"}


id: YDR315C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01148":null,"YDR315C":null},"has_protein_features":false,"name":"IPK1","ortholog_annotations":[{"gene_uniquename":"YDR315C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01148","reference_uniquename":"PMID:29761456"}],"product":"Inositol 1,3,4,5,6-pentakisphosphate 2-kinase; nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable; human IPPK can complement ipk1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002723","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR315C"}


id: YDR316W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05693":null,"YDR316W":null},"has_protein_features":false,"name":"OMS1","ortholog_annotations":[{"gene_uniquename":"YDR316W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05693","reference_uniquename":"PMID:29761456"}],"product":"Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif and is predicted to be an RNA methyltransferase; multicopy suppressor of respiratory defects caused by OXA1 mutations","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR316W"}


id: YDR317W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HIM1","product":"Protein of unknown function involved in DNA repair","secondary_identifier":"SGD:S000002725","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR317W"}


id: YDR318W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04581":null,"YDR318W":null},"has_protein_features":false,"name":"MCM21","ortholog_annotations":[{"gene_uniquename":"YDR318W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04581","reference_uniquename":"PMID:29761456"}],"product":"Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; modified by sumoylation; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002726","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR318W"}


id: YDR319C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01180":null,"YDR319C":null},"has_protein_features":false,"name":"YFT2","ortholog_annotations":[{"gene_uniquename":"YDR319C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01180","reference_uniquename":"PMID:29761456"}],"product":"Protein needed for ER membrane biosynthesis in response to ER stress; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis; homologous to human FIT2/FITM2, a fatty acyl-CoA diphosphatase; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002727","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR319C"}


id: YDR320C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05296":null,"YDR320C":null},"has_protein_features":false,"name":"SWA2","ortholog_annotations":[{"gene_uniquename":"YDR320C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05296","reference_uniquename":"PMID:29761456"}],"product":"Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles; required for propagation of [URE3] prion variant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002728","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR320C"}


id: YDR320C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05319":null,"YDR320C-A":null},"has_protein_features":false,"name":"DAD4","ortholog_annotations":[{"gene_uniquename":"YDR320C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05319","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007604","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR320C-A"}


id: YDR320W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene DAD4/YDR320C-A","secondary_identifier":"SGD:S000028821","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR320W-B"}


id: YDR321W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ASP1","product":"Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia; important enzyme for the treatment of acute lymphoblastic leukemia; has low glutaminase activity and dependence; synthesized constitutively","secondary_identifier":"SGD:S000002729","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR321W"}


id: YDR322C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04122":null,"YDR322C-A":null},"has_protein_features":false,"name":"TIM11","ortholog_annotations":[{"gene_uniquename":"YDR322C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04122","reference_uniquename":"PMID:29761456"}],"product":"Subunit e of mitochondrial F1F0-ATPase; ATPase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase, which in turn determines the shape of inner membrane cristae","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR322C-A"}


id: YDR322W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01727":null,"YDR322W":null},"has_protein_features":false,"name":"MRPL35","ortholog_annotations":[{"gene_uniquename":"YDR322W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01727","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; involved together with Mrp7p in assembly of cytochrome c oxidase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002730","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR322W"}


id: YDR323C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02587":null,"YDR323C":null},"has_protein_features":false,"name":"PEP7","ortholog_annotations":[{"gene_uniquename":"YDR323C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02587","reference_uniquename":"PMID:29761456"}],"product":"Adaptor protein involved in vesicle-mediated vacuolar protein sorting; multivalent adaptor protein; facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002731","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR323C"}


id: YDR324C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00879":null,"YDR324C":null},"has_protein_features":false,"name":"UTP4","ortholog_annotations":[{"gene_uniquename":"YDR324C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00879","reference_uniquename":"PMID:29761456"}],"product":"Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript; Small Subunit processome is also known as SSU processome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002732","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR324C"}


id: YDR325W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03682":null,"YDR325W":null},"has_protein_features":false,"name":"YCG1","ortholog_annotations":[{"gene_uniquename":"YDR325W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03682","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding by the complex; required for tRNA genes clustering at the nucleolus; required for replication slow zone breakage following Mec1p inactivation; transcription is cell cycle regulated, peaking in mitosis and declining in G1; protein is constitutively degraded by the proteasome; rate limiting for condensin recruitment to chromatin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002733","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR325W"}


id: YDR326C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01329":null,"YDR326C":null},"has_protein_features":false,"name":"YSP2","ortholog_annotations":[{"gene_uniquename":"YDR326C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01329","reference_uniquename":"PMID:29761456"}],"product":"Sterol-binding protein; has a probable role in retrograde transport of sterols from the plasma membrane to the ER; contains two StART-like domains that bind sterols and a GRAM domain; co-localizes to puncta in the cortical ER with Sip3p; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002734","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR326C"}


id: YDR327W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SKP1","secondary_identifier":"SGD:S000002735","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR327W"}


id: YDR328C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03219":null,"YDR328C":null},"has_protein_features":false,"name":"SKP1","ortholog_annotations":[{"gene_uniquename":"YDR328C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03219","reference_uniquename":"PMID:29761456"}],"product":"Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002736","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR328C"}


id: YDR329C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04763":null,"YDR329C":null},"has_protein_features":false,"name":"PEX3","ortholog_annotations":[{"gene_uniquename":"YDR329C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04763","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal membrane protein (PMP); required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002737","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR329C"}


id: YDR330W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02021":null,"YDR330W":null},"has_protein_features":false,"name":"UBX5","ortholog_annotations":[{"gene_uniquename":"YDR330W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02021","reference_uniquename":"PMID:29761456"}],"product":"UBX domain-containing protein that interacts with Cdc48p; ubiquitin regulatory X is also known as UBX","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002738","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR330W"}


id: YDR331W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03672":null,"YDR331W":null},"has_protein_features":false,"name":"GPI8","ortholog_annotations":[{"gene_uniquename":"YDR331W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03672","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of the ER membrane GPI transamidase complex; involved in adding glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; luminally-oriented type I integral membrane glycoprotein of the ER; human PIGK protein is a functional homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002739","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR331W"}


id: YDR332W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04064":null,"YDR332W":null},"has_protein_features":false,"name":"IRC3","ortholog_annotations":[{"gene_uniquename":"YDR332W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04064","reference_uniquename":"PMID:29761456"}],"product":"Double-stranded DNA-dependent helicase of the DExH/D-box family; branch point-binding helicase that preferentially unwinds the nascent lagging strand with a 3' to 5' polarity at a replication fork; contains double-stranded DNA translocase activity; responsible for DNA branch migration; required for maintenance of the mitochondrial (mt) genome; localizes to the mitochondrial matrix; monomeric","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002740","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR332W"}


id: YDR333C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01497":null,"YDR333C":null},"has_protein_features":false,"name":"RQC1","ortholog_annotations":[{"gene_uniquename":"YDR333C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01497","reference_uniquename":"PMID:29761456"}],"product":"Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Rkr1p-Rqc2p-Cdc48p-Npl4p-Ufd1p) is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Rkr1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002741","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR333C"}


id: YDR334W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02571":null,"YDR334W":null},"has_protein_features":false,"name":"SWR1","ortholog_annotations":[{"gene_uniquename":"YDR334W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02571","reference_uniquename":"PMID:29761456"}],"product":"Swi2/Snf2-related ATPase; catalytic subunit of SWR1 complex, which exchanges histone variant H2A.Z (Htz1p) for chromatin-bound histone H2A; N-terminus can deliver H2A.Z-H2B dimer to DNA-(H3-H4)2 tetrasome; relocalizes to cytosol in response to hypoxia; chronological aging factor, mediates lifespan extension by dietary restriction","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002742","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR334W"}


id: YDR335W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01534":null,"YDR335W":null},"has_protein_features":false,"name":"MSN5","ortholog_annotations":[{"gene_uniquename":"YDR335W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01534","reference_uniquename":"PMID:29761456"}],"product":"Karyopherin; involved in nuclear import and export of proteins, including import of replication protein A and export of Far1p and transcription factors Swi5p, Swi6p, Msn2p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm; exportin-5 homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002743","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR335W"}


id: YDR336W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRX8","product":"Protein that associates with mitochondrial ribosome; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene","secondary_identifier":"SGD:S000002744","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR336W"}


id: YDR337W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03053":null,"YDR337W":null},"has_protein_features":false,"name":"MRPS28","ortholog_annotations":[{"gene_uniquename":"YDR337W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03053","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002745","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR337W"}


id: YDR338C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01145":null,"SJAG_03951":null,"YDR338C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR338C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01145","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR338C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03951","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002746","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR338C"}


id: YDR339C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00772":null,"YDR339C":null},"has_protein_features":false,"name":"FCF1","ortholog_annotations":[{"gene_uniquename":"YDR339C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00772","reference_uniquename":"PMID:29761456"}],"product":"PINc domain endonuclease; required for early cleavage of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002747","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR339C"}


id: YDR340W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000002748","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR340W"}


id: YDR341C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00653":null,"YDR341C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR341C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00653","reference_uniquename":"PMID:29761456"}],"product":"Arginyl-tRNA synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDR341C has a paralog, MSR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002749","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR341C"}


id: YDR342C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YDR342C":null},"has_protein_features":false,"name":"HXT7","ortholog_annotations":[{"gene_uniquename":"YDR342C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR342C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR342C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR342C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR342C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR342C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR342C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002750","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR342C"}


id: YDR343C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YDR343C":null},"has_protein_features":false,"name":"HXT6","ortholog_annotations":[{"gene_uniquename":"YDR343C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR343C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR343C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR343C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR343C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR343C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR343C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3; HXT6 has a paralog, HXT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002751","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR343C"}


id: YDR344C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000002752","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR344C"}


id: YDR345C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YDR345C":null},"has_protein_features":false,"name":"HXT3","ortholog_annotations":[{"gene_uniquename":"YDR345C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR345C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR345C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR345C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR345C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR345C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDR345C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:26896847"}],"product":"Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000002753","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR345C"}


id: YDR346C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03690":null,"YDR346C":null},"has_protein_features":false,"name":"SVF1","ortholog_annotations":[{"gene_uniquename":"YDR346C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03690","reference_uniquename":"PMID:29761456"}],"product":"Protein with a potential role in cell survival pathways; required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002754","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR346C"}


id: YDR347W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01734":null,"SJAG_04788":null,"YDR347W":null},"has_protein_features":false,"name":"MRP1","ortholog_annotations":[{"gene_uniquename":"YDR347W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01734","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR347W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04788","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002755","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR347W"}


id: YDR348C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04050":null,"YDR348C":null},"has_protein_features":false,"name":"PAL1","ortholog_annotations":[{"gene_uniquename":"YDR348C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04050","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function thought to be involved in endocytosis; physically interacts with Ede1p and is found at endocytic sites at cell periphery during early stages of endocytosis; green fluorescent protein (GFP)-fusion protein localizes to bud neck; potential Cdc28p substrate; similar to S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress; PAL1 has a paralog, YHR097C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002756","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR348C"}


id: YDR349C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00109":null,"SJAG_00254":null,"SJAG_00784":null,"SJAG_02260":null,"YDR349C":null},"has_protein_features":false,"name":"YPS7","ortholog_annotations":[{"gene_uniquename":"YDR349C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00109","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR349C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00254","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR349C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00784","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR349C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02260","reference_uniquename":"PMID:29761456"}],"product":"Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002757","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR349C"}


id: YDR350C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATP22","product":"Specific translational activator for the mitochondrial ATP6 mRNA; Atp6p encodes a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane","secondary_identifier":"SGD:S000002758","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR350C"}


id: YDR351W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SBE2","product":"Protein required for bud growth; involved in transport of cell wall components from the Golgi to the cell surface; SBE2 has a paralog, SBE22, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002759","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR351W"}


id: YDR352W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00051":null,"SJAG_04787":null,"YDR352W":null},"has_protein_features":false,"name":"YPQ2","ortholog_annotations":[{"gene_uniquename":"YDR352W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00051","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR352W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04787","reference_uniquename":"PMID:29761456"}],"product":"Putative vacuolar membrane transporter for cationic amino acids; involved in vacuolar export of arginine under nitrogen starvation conditions; appears to be inactive under nitrogen replete conditions; may contribute to amino acid homeostasis; vacuolar membrane protein; member of the PQ-loop family, containing seven transmembrane domains; homologous to the human lysosomal cationic amino acid exporter PQLC2; null mutant is functionally complemented by the rat PQLC2 vacuolar transporter","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002760","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR352W"}


id: YDR353W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03653":null,"SJAG_04399":null,"YDR353W":null},"has_protein_features":false,"name":"TRR1","ortholog_annotations":[{"gene_uniquename":"YDR353W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03653","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR353W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04399","reference_uniquename":"PMID:26896847"}],"product":"Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002761","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR353W"}


id: YDR354C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps TRP4; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR354C-A"}


id: YDR354W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03167":null,"YDR354W":null},"has_protein_features":false,"name":"TRP4","ortholog_annotations":[{"gene_uniquename":"YDR354W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03167","reference_uniquename":"PMID:29761456"}],"product":"Anthranilate phosphoribosyl transferase; transferase of the tryptophan biosynthetic pathway; catalyzes the phosphoribosylation of anthranilate; subject to the general control system of amino acid biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002762","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR354W"}


id: YDR355C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W","secondary_identifier":"SGD:S000002763","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR355C"}


id: YDR356W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02246":null,"YDR356W":null},"has_protein_features":false,"name":"SPC110","ortholog_annotations":[{"gene_uniquename":"YDR356W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02246","reference_uniquename":"PMID:29761456"}],"product":"Inner plaque spindle pole body (SPB) component; gamma-tubulin small complex (gamma-TuSC) receptor that interacts with Spc98p to recruit the complex to the nuclear side of the SPB, connecting nuclear microtubules to the SPB; promotes gamma-TuSC assembly and oligomerization to initiate microtubule nucleation; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner; ortholog of human pericentrin (kendrin)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002764","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR356W"}


id: YDR357C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CNL1","product":"Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000002765","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR357C"}


id: YDR358W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02912":null,"SJAG_03756":null,"YDR358W":null},"has_protein_features":false,"name":"GGA1","ortholog_annotations":[{"gene_uniquename":"YDR358W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02912","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR358W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03756","reference_uniquename":"PMID:29761456"}],"product":"Golgi-localized protein with homology to gamma-adaptin; interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi; GGA1 has a paralog, GGA2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002766","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR358W"}


id: YDR359C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00783":null,"YDR359C":null},"has_protein_features":false,"name":"EAF1","ortholog_annotations":[{"gene_uniquename":"YDR359C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00783","reference_uniquename":"PMID:29761456"}],"product":"Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002767","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR359C"}


id: YDR360W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OPI7","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C","secondary_identifier":"SGD:S000002768","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR360W"}


id: YDR361C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00753":null,"YDR361C":null},"has_protein_features":false,"name":"BCP1","ortholog_annotations":[{"gene_uniquename":"YDR361C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00753","reference_uniquename":"PMID:29761456"}],"product":"Essential nuclear chaperone for ribosomal protein Rpl23p; involved in nuclear export of Mss4p; Mss4p is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002769","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR361C"}


id: YDR362C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00585":null,"YDR362C":null},"has_protein_features":false,"name":"TFC6","ortholog_annotations":[{"gene_uniquename":"YDR362C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00585","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002770","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR362C"}


id: YDR363W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00177":null,"YDR363W":null},"has_protein_features":false,"name":"ESC2","ortholog_annotations":[{"gene_uniquename":"YDR363W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00177","reference_uniquename":"PMID:29761456"}],"product":"Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002771","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR363W"}


id: YDR363W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01652":null,"YDR363W-A":null},"has_protein_features":false,"name":"SEM1","ortholog_annotations":[{"gene_uniquename":"YDR363W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01652","reference_uniquename":"PMID:29761456"}],"product":"19S proteasome regulatory particle lid subcomplex component; role in Ub-dependent proteolysis and proteasome stability; involved in TREX-2 mediated mRNA export, and in the prevention of transcription-associated genome instability; ubiquitinated by Nedd4-like E3-ligase, Rsp5p; human ortholog DSS1, a BRCA1 binding protein implicated in cancer, complements the yeast null; drives trinucleotide repeat expansion; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR363W-A"}


id: YDR364C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00639":null,"YDR364C":null},"has_protein_features":false,"name":"CDC40","ortholog_annotations":[{"gene_uniquename":"YDR364C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00639","reference_uniquename":"PMID:29761456"}],"product":"Pre-mRNA splicing factor; important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression, particularly at the G1/S phase transition; required for DNA synthesis during mitosis and meiosis; has WD repeats; thermosensitivity of the cdc40 null mutant is functionally complemented by a chimeric construct containing the N-terminal 156 amino acids of yeast Cdc40p fused to the C-terminal two thirds (297 amino acids) of human CDC40","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002772","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR364C"}


id: YDR365C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00813":null,"YDR365C":null},"has_protein_features":false,"name":"ESF1","ortholog_annotations":[{"gene_uniquename":"YDR365C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00813","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002773","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR365C"}


id: YDR366C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MOR1","product":"Putative protein of unknown function","secondary_identifier":"SGD:S000002774","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR366C"}


id: YDR367W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03015":null,"YDR367W":null},"has_protein_features":false,"name":"KEI1","ortholog_annotations":[{"gene_uniquename":"YDR367W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03015","reference_uniquename":"PMID:29761456"}],"product":"Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002775","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR367W"}


id: YDR368W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02010":null,"YDR368W":null},"has_protein_features":false,"name":"YPR1","ortholog_annotations":[{"gene_uniquename":"YDR368W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02010","reference_uniquename":"PMID:29761456"}],"product":"NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; human homolog AKR1B1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002776","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR368W"}


id: YDR369C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00640":null,"YDR369C":null},"has_protein_features":false,"name":"XRS2","ortholog_annotations":[{"gene_uniquename":"YDR369C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00640","reference_uniquename":"PMID:29761456"}],"product":"FHA domain-containing component of the Mre11 complex; MRE11-RAD50-XRS2 complex is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling;  FHA domain is required for activation of Tel1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002777","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR369C"}


id: YDR370C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DXO1","product":"mRNA 5'-end-capping quality-control protein; has distributive, 5'-3' exoRNase activity; involved in the decapping of nicotinamide adenine dinucleotide (NAD) capped nuclear NAD-RNAs; similar to Rai1p","secondary_identifier":"SGD:S000002778","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR370C"}


id: YDR371C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene CTS2/YDR371W; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028822","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR371C-A"}


id: YDR371W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00620":null,"YDR371W":null},"has_protein_features":false,"name":"CTS2","ortholog_annotations":[{"gene_uniquename":"YDR371W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00620","reference_uniquename":"PMID:29761456"}],"product":"Putative chitinase; functionally complements A. gossypii cts2 mutant sporulation defect","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002779","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR371W"}


id: YDR372C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01516":null,"YDR372C":null},"has_protein_features":false,"name":"VPS74","ortholog_annotations":[{"gene_uniquename":"YDR372C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01516","reference_uniquename":"PMID:29761456"}],"product":"Golgi PI4K effector, PtdIns4P sensor, and retention receptor; interacts with glycosyltransferases, and in the PtdIns4P-bound state mediates retention of these enzymes in the Golgi; PtdIns4P sensor that limits PI4K signaling and regulates lipid homeostasis, interacting with the catalytic domain of Sac1p, the major PtdIns4P phosphatase, directing dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; contributes to telomere function; ortholog of human GOLPH3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002780","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR372C"}


id: YDR373W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00296":null,"YDR373W":null},"has_protein_features":false,"name":"FRQ1","ortholog_annotations":[{"gene_uniquename":"YDR373W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00296","reference_uniquename":"PMID:29761456"}],"product":"N-myristoylated calcium-binding protein; may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily; human NCS1 functionally complements the heat sensitivity of a frq1 ts mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002781","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR373W"}


id: YDR374C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02622":null,"YDR374C":null},"has_protein_features":false,"name":"PHO92","ortholog_annotations":[{"gene_uniquename":"YDR374C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02622","reference_uniquename":"PMID:29761456"}],"product":"Posttranscriptional regulator of phosphate and glucose metabolism; facilitates PHO4 mRNA degradation by interacting with Pop2p; regulates PHO4 mRNA stability by binding to PHO4's 3'UTR in a phosphate-dependent manner; contains highly conserved YTH (YT521-B Homology) domain that exhibits RNA-binding activity; human homolog YTHDF2 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002782","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR374C"}


id: YDR374W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05321":null,"YDR374W-A":null},"has_protein_features":false,"name":"WIP1","ortholog_annotations":[{"gene_uniquename":"YDR374W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05321","reference_uniquename":"PMID:29761456"}],"product":"Kinetochore localized protein of unknown function; interacts with Cnn1p (CENP-T); orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-W and fission yeast new1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000113553","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR374W-A"}


id: YDR375C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01405":null,"YDR375C":null},"has_protein_features":false,"name":"BCS1","ortholog_annotations":[{"gene_uniquename":"YDR375C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01405","reference_uniquename":"PMID:29761456"}],"product":"Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane and delivers it to an assembly intermediate of respiratory Complex III; also required for assembly of the Qcr10p subunit; mutation is functionally complemented by human homolog BCS1L, linked to neonatal diseases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002783","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR375C"}


id: YDR376W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01063":null,"YDR376W":null},"has_protein_features":false,"name":"ARH1","ortholog_annotations":[{"gene_uniquename":"YDR376W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01063","reference_uniquename":"PMID:29761456"}],"product":"Oxidoreductase of the mitochondrial inner membrane; involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR376W"}


id: YDR377W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05204":null,"YDR377W":null},"has_protein_features":false,"name":"ATP17","ortholog_annotations":[{"gene_uniquename":"YDR377W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05204","reference_uniquename":"PMID:29761456"}],"product":"Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002785","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR377W"}


id: YDR378C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03954":null,"YDR378C":null},"has_protein_features":false,"name":"LSM6","ortholog_annotations":[{"gene_uniquename":"YDR378C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03954","reference_uniquename":"PMID:29761456"}],"product":"Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002786","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR378C"}


id: YDR379C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07005":null,"YDR379C-A":null},"has_protein_features":false,"name":"SDH6","ortholog_annotations":[{"gene_uniquename":"YDR379C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07005","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; member of the LYR protein family; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007605","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR379C-A"}


id: YDR379W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04522":null,"SJAG_04765":null,"YDR379W":null},"has_protein_features":false,"name":"RGA2","ortholog_annotations":[{"gene_uniquename":"YDR379W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04522","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR379W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04765","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p; RGA2 has a paralog, RGA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002787","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR379W"}


id: YDR380W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ARO10","product":"Phenylpyruvate decarboxylase; catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway; involved in protein N-terminal Met and Ala catabolism","secondary_identifier":"SGD:S000002788","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR380W"}


id: YDR381C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COI1","product":"Mitochondrial assembly factor; important for assembly of the mitochondrial respiratory chain bc1 complex (complex III), cytochrome oxidase (complex IV), and the complex III-complex IV supercomplex; embedded in the mitochondrial inner membrane, facing the intermembrane space","secondary_identifier":"SGD:S000007650","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR381C-A"}


id: YDR381W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01717":null,"YDR381W":null},"has_protein_features":false,"name":"YRA1","ortholog_annotations":[{"gene_uniquename":"YDR381W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01717","reference_uniquename":"PMID:29761456"}],"product":"Nuclear polyadenylated RNA-binding protein; required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; interacts with DBP2; inhibits the helicase activity of Dbp2; functionally redundant with Yra2p, another REF family member","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002789","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR381W"}


id: YDR382W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01128":null,"SJAG_02871":null,"YDR382W":null},"has_protein_features":false,"name":"RPP2B","ortholog_annotations":[{"gene_uniquename":"YDR382W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01128","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR382W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02871","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein P2 beta; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002790","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR382W"}


id: YDR383C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04255":null,"YDR383C":null},"has_protein_features":false,"name":"NKP1","ortholog_annotations":[{"gene_uniquename":"YDR383C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04255","reference_uniquename":"PMID:29761456"}],"product":"Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002791","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR383C"}


id: YDR384C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01505":null,"YDR384C":null},"has_protein_features":false,"name":"ATO3","ortholog_annotations":[{"gene_uniquename":"YDR384C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01505","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane protein, putative ammonium transporter; regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002792","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR384C"}


id: YDR385W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01438":null,"SJAG_05332":null,"YDR385W":null},"has_protein_features":false,"name":"EFT2","ortholog_annotations":[{"gene_uniquename":"YDR385W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01438","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR385W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05332","reference_uniquename":"PMID:29761456"}],"product":"Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002793","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR385W"}


id: YDR386W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01044":null,"YDR386W":null},"has_protein_features":false,"name":"MUS81","ortholog_annotations":[{"gene_uniquename":"YDR386W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01044","reference_uniquename":"PMID:29761456"}],"product":"Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); helix-hairpin-helix protein; phosphorylation of non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates function of Mms4p-Mus81p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002794","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR386W"}


id: YDR387C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03595":null,"SJAG_04506":null,"YDR387C":null},"has_protein_features":false,"name":"CIN10","ortholog_annotations":[{"gene_uniquename":"YDR387C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03595","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR387C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04506","reference_uniquename":"PMID:29761456"}],"product":"Putative transporter; member of the sugar porter family; non-essential gene; overexpression results in elevated colony sectoring, an indicator of chromosomal instability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002795","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR387C"}


id: YDR388W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00185":null,"YDR388W":null},"has_protein_features":false,"name":"RVS167","ortholog_annotations":[{"gene_uniquename":"YDR388W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00185","reference_uniquename":"PMID:29761456"}],"product":"Calmodulin-binding actin-associated protein; roles in endocytic membrane tabulation and constriction, and exocytosis; N-BAR domain protein that interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin; necessary for efficient trafficking of CoQ6 to mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002796","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR388W"}


id: YDR389W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04462":null,"YDR389W":null},"has_protein_features":false,"name":"SAC7","ortholog_annotations":[{"gene_uniquename":"YDR389W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04462","reference_uniquename":"PMID:29761456"}],"product":"GTPase activating protein (GAP) for Rho1p; regulator of a Tor2p-mediated, Rho1p GTPase switch that controls organization of the actin cytoskeleton; negative regulator of the RHO1-PKC1-MAPK cell integrity (CWI) and membrane fluidity homeostasis signaling pathways; potential Cdc28p substrate; SAC7 has a paralog, BAG7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002797","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR389W"}


id: YDR390C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00604":null,"YDR390C":null},"has_protein_features":false,"name":"UBA2","ortholog_annotations":[{"gene_uniquename":"YDR390C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00604","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002798","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR390C"}


id: YDR391C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01619":null,"YDR391C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR391C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01619","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002799","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR391C"}


id: YDR392W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03668":null,"YDR392W":null},"has_protein_features":false,"name":"SPT3","ortholog_annotations":[{"gene_uniquename":"YDR392W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03668","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SAGA and SAGA-like transcriptional regulatory complexes; interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002800","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR392W"}


id: YDR393W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04965":null,"YDR393W":null},"has_protein_features":false,"name":"SHE9","ortholog_annotations":[{"gene_uniquename":"YDR393W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04965","reference_uniquename":"PMID:29761456"}],"product":"Protein required for normal mitochondrial morphology; localized to mitochondrial inner membrane; may be involved in fission of the inner membrane; forms a homo-oligomeric complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002801","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR393W"}


id: YDR394W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04477":null,"YDR394W":null},"has_protein_features":false,"name":"RPT3","ortholog_annotations":[{"gene_uniquename":"YDR394W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04477","reference_uniquename":"PMID:29761456"}],"product":"ATPase of the 19S regulatory particle of the 26S proteasome; one of ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002802","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR394W"}


id: YDR395W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03693":null,"YDR395W":null},"has_protein_features":false,"name":"SXM1","ortholog_annotations":[{"gene_uniquename":"YDR395W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03693","reference_uniquename":"PMID:29761456"}],"product":"Nuclear transport factor (karyopherin); involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002803","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR395W"}


id: YDR396W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex","secondary_identifier":"SGD:S000002804","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR396W"}


id: YDR397C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03095":null,"YDR397C":null},"has_protein_features":false,"name":"NCB2","ortholog_annotations":[{"gene_uniquename":"YDR397C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03095","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta; complex also includes Bur6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002805","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR397C"}


id: YDR398W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02499":null,"SJAG_02702":null,"YDR398W":null},"has_protein_features":false,"name":"UTP5","ortholog_annotations":[{"gene_uniquename":"YDR398W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02499","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR398W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02702","reference_uniquename":"PMID:29761456"}],"product":"Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR398W"}


id: YDR399W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06634":null,"YDR399W":null},"has_protein_features":false,"name":"HPT1","ortholog_annotations":[{"gene_uniquename":"YDR399W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06634","reference_uniquename":"PMID:29761456"}],"product":"Dimeric hypoxanthine-guanine phosphoribosyltransferase; catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR399W"}


id: YDR400W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00957":null,"YDR400W":null},"has_protein_features":false,"name":"URH1","ortholog_annotations":[{"gene_uniquename":"YDR400W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00957","reference_uniquename":"PMID:29761456"}],"product":"Uridine nucleosidase (uridine-cytidine N-ribohydrolase); cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR400W"}


id: YDR401W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002809","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR401W"}


id: YDR402C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DIT2","product":"N-formyltyrosine oxidase; sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","secondary_identifier":"SGD:S000002810","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR402C"}


id: YDR403W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DIT1","product":"Sporulation-specific enzyme required for spore wall maturation; involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure","secondary_identifier":"SGD:S000002811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR403W"}


id: YDR404C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01436":null,"YDR404C":null},"has_protein_features":false,"name":"RPB7","ortholog_annotations":[{"gene_uniquename":"YDR404C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01436","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR404C"}


id: YDR405W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00799":null,"YDR405W":null},"has_protein_features":false,"name":"MRP20","ortholog_annotations":[{"gene_uniquename":"YDR405W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00799","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002813","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR405W"}


id: YDR406W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04277":null,"YDR406W":null},"has_protein_features":false,"name":"PDR15","ortholog_annotations":[{"gene_uniquename":"YDR406W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane ATP binding cassette (ABC) transporter; multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element; PDR15 has a paralog, PDR5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002814","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR406W"}


id: YDR406W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028543","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR406W-A"}


id: YDR407C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04358":null,"YDR407C":null},"has_protein_features":false,"name":"TRS120","ortholog_annotations":[{"gene_uniquename":"YDR407C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04358","reference_uniquename":"PMID:29761456"}],"product":"Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002815","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR407C"}


id: YDR408C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01814":null,"YDR408C":null},"has_protein_features":false,"name":"ADE8","ortholog_annotations":[{"gene_uniquename":"YDR408C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01814","reference_uniquename":"PMID:29761456"}],"product":"Phosphoribosyl-glycinamide transformylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002816","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR408C"}


id: YDR409W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00727":null,"YDR409W":null},"has_protein_features":false,"name":"SIZ1","ortholog_annotations":[{"gene_uniquename":"YDR409W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00727","reference_uniquename":"PMID:29761456"}],"product":"SUMO E3 ligase; promotes attachment of small ubiquitin-related modifier sumo (Smt3p) to primarily cytoplasmic proteins; regulates Rsp5p ubiquitin ligase activity and is in turn itself regulated by Rsp5p; required for sumoylation of septins and histone H3 variant Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; localizes to the septin ring; acts as an adapter between E2, Ubc9p and substrates; tends to compensate for survival of DNA damage in absence of Nfi1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002817","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR409W"}


id: YDR410C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05016":null,"YDR410C":null},"has_protein_features":false,"name":"STE14","ortholog_annotations":[{"gene_uniquename":"YDR410C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05016","reference_uniquename":"PMID:29761456"}],"product":"Farnesyl cysteine-carboxyl methyltransferase; mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002818","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR410C"}


id: YDR411C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00681":null,"SJAG_03841":null,"YDR411C":null},"has_protein_features":false,"name":"DFM1","ortholog_annotations":[{"gene_uniquename":"YDR411C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00681","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR411C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03841","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum (ER) localized protein; involved in ER-associated protein degradation (ERAD), ER stress, and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002819","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR411C"}


