# genes

id: YLR425W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03704":null,"YLR425W":null},"has_protein_features":false,"name":"TUS1","ortholog_annotations":[{"gene_uniquename":"YLR425W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03704","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004417","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR425W"}


id: YLR426W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00593":null,"YLR426W":null},"has_protein_features":false,"name":"TDA5","ortholog_annotations":[{"gene_uniquename":"YLR426W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00593","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004418","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR426W"}


id: YLR427W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02415":null,"YLR427W":null},"has_protein_features":false,"name":"MAG2","ortholog_annotations":[{"gene_uniquename":"YLR427W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02415","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004419","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR427W"}


id: YLR428C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1","secondary_identifier":"SGD:S000004420","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR428C"}


id: YLR429W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00677":null,"YLR429W":null},"has_protein_features":false,"name":"CRN1","ortholog_annotations":[{"gene_uniquename":"YLR429W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00677","reference_uniquename":"PMID:29761456"}],"product":"Coronin; cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR429W"}


id: YLR430W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02242":null,"SJAG_03923":null,"YLR430W":null},"has_protein_features":false,"name":"SEN1","ortholog_annotations":[{"gene_uniquename":"YLR430W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02242","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR430W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03923","reference_uniquename":"PMID:29761456"}],"product":"ATP-dependent 5' to 3' RNA/DNA and DNA helicase; subunit of the exosome-associated Nrd1p complex that mediates 3' end formation of snRNAs, snoRNAs, CUTs and some mRNAs; helicase-independent role in transcription-coupled repair; coordinates replication with transcription, associating with moving forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of juvenile ALS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR430W"}


id: YLR431C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG23","product":"Peripheral membrane protein required for autophagy and CVT; required for cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p","secondary_identifier":"SGD:S000004423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR431C"}


id: YLR432W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01298":null,"YLR432W":null},"has_protein_features":false,"name":"IMD3","ortholog_annotations":[{"gene_uniquename":"YLR432W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01298","reference_uniquename":"PMID:29761456"}],"product":"Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD3 has a paralog, IMD4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004424","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR432W"}


id: YLR433C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03631":null,"YLR433C":null},"has_protein_features":false,"name":"CNA1","ortholog_annotations":[{"gene_uniquename":"YLR433C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03631","reference_uniquename":"PMID:29761456"}],"product":"Calcineurin A; one isoform (the other is Cmp2p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CNA1 has a paralog, CMP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR433C"}


id: YLR434C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W","secondary_identifier":"SGD:S000004426","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR434C"}


id: YLR435W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02358":null,"YLR435W":null},"has_protein_features":false,"name":"TSR2","ortholog_annotations":[{"gene_uniquename":"YLR435W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02358","reference_uniquename":"PMID:29761456"}],"product":"Protein with a potential role in pre-rRNA processing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004427","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR435W"}


id: YLR436C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00567":null,"SJAG_03278":null,"SJAG_03634":null,"YLR436C":null},"has_protein_features":false,"name":"ECM30","ortholog_annotations":[{"gene_uniquename":"YLR436C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00567","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR436C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03278","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR436C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03634","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004428","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR436C"}


id: YLR437C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01348":null,"SJAG_02874":null,"YLR437C":null},"has_protein_features":false,"name":"DIF1","ortholog_annotations":[{"gene_uniquename":"YLR437C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01348","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR437C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02874","reference_uniquename":"PMID:29761456"}],"product":"Protein that regulates nuclear import of Rnr2p and Rnr4p; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half shows similarity to S. pombe Spd1 protein; DIF1 has a paralog, SML1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR437C"}


id: YLR437C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W","secondary_identifier":"SGD:S000028684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR437C-A"}


id: YLR438C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03460":null,"YLR438C-A":null},"has_protein_features":false,"name":"LSM3","ortholog_annotations":[{"gene_uniquename":"YLR438C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03460","reference_uniquename":"PMID:29761456"}],"product":"Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR438C-A"}


id: YLR438W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00495":null,"YLR438W":null},"has_protein_features":false,"name":"CAR2","ortholog_annotations":[{"gene_uniquename":"YLR438W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00495","reference_uniquename":"PMID:29761456"}],"product":"L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004430","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR438W"}


id: YLR439W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01045":null,"YLR439W":null},"has_protein_features":false,"name":"MRPL4","ortholog_annotations":[{"gene_uniquename":"YLR439W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01045","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR439W"}


id: YLR440C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04956":null,"YLR440C":null},"has_protein_features":false,"name":"SEC39","ortholog_annotations":[{"gene_uniquename":"YLR440C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04956","reference_uniquename":"PMID:29761456"}],"product":"Component of the Dsl1p tethering complex; this complex interacts with ER SNAREs Sec20p and Use1p; mediates Sey1p-independent homotypic ER fusion; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004432","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR440C"}


id: YLR441C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00733":null,"SJAG_02522":null,"YLR441C":null},"has_protein_features":false,"name":"RPS1A","ortholog_annotations":[{"gene_uniquename":"YLR441C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00733","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR441C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02522","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004433","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR441C"}


id: YLR442C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SIR3","product":"Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; required for telomere hypercluster formation in quiescent yeast cells; has paralog ORC1 from whole genome duplication","secondary_identifier":"SGD:S000004434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR442C"}


id: YLR443W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM7","product":"Putative integral membrane protein with a role in calcium uptake; non-essential protein; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency","secondary_identifier":"SGD:S000004435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR443W"}


id: YLR444C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004436","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR444C"}


id: YLR445W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GMC2","product":"Protein involved in meiotic crossing over; component of the Synaptonemal Complex (SC) along with Ecm11p; required for the efficient loading of the SC transverse filament protein, Zip1p; promotes SUMOylation of Ecm11p; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor","secondary_identifier":"SGD:S000004437","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR445W"}


id: YLR446W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene","secondary_identifier":"SGD:S000004438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR446W"}


id: YLR447C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01913":null,"YLR447C":null},"has_protein_features":false,"name":"VMA6","ortholog_annotations":[{"gene_uniquename":"YLR447C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01913","reference_uniquename":"PMID:29761456"}],"product":"Subunit d of the V0 integral membrane domain of V-ATPase; part of the electrogenic proton pump found in the endomembrane system; required for V1 domain assembly on the vacuolar membrane; the V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase) has five subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR447C"}


id: YLR448W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03666":null,"YLR448W":null},"has_protein_features":false,"name":"RPL6B","ortholog_annotations":[{"gene_uniquename":"YLR448W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03666","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004440","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR448W"}


id: YLR449W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01005":null,"SJAG_03905":null,"YLR449W":null},"has_protein_features":false,"name":"FPR4","ortholog_annotations":[{"gene_uniquename":"YLR449W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01005","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR449W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03905","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-prolyl cis-trans isomerase (PPIase); nuclear proline isomerase; affects expression of multiple genes via its role in nucleosome assembly; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; contains a nucleoplasmin-like fold and can form pentamers","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR449W"}


id: YLR450W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03715":null,"YLR450W":null},"has_protein_features":false,"name":"HMG2","ortholog_annotations":[{"gene_uniquename":"YLR450W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03715","reference_uniquename":"PMID:29761456"}],"product":"HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at nuclear periphery upon DNA replication stress; HMG2 has a paralog, HMG1, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg2 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004442","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR450W"}


id: YLR451W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LEU3","product":"Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation","secondary_identifier":"SGD:S000004443","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR451W"}


id: YLR452C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00990":null,"YLR452C":null},"has_protein_features":false,"name":"SST2","ortholog_annotations":[{"gene_uniquename":"YLR452C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00990","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein for Gpa1p; regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004444","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR452C"}


id: YLR453C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RIF2","product":"Protein that binds to the Rap1p C-terminus; acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation; RIF2 has a paralog, ORC4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004445","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR453C"}


id: YLR454W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01564":null,"YLR454W":null},"has_protein_features":false,"name":"FMP27","ortholog_annotations":[{"gene_uniquename":"YLR454W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01564","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004446","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR454W"}


id: YLR455W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00411":null,"SJAG_00545":null,"SJAG_01009":null,"YLR455W":null},"has_protein_features":false,"name":"PDP3","ortholog_annotations":[{"gene_uniquename":"YLR455W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00411","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR455W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00545","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR455W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01009","reference_uniquename":"PMID:29761456"}],"product":"Component of the NuA3b histone acetyltransferase complex; regulates interaction between NuA3b and H3K36me3 at the transcribed regions of genes; contains PWWP domain; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004447","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR455W"}


id: YLR456W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02770":null,"YLR456W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR456W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02770","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; predicted to encode a pyridoxal 5'-phosphate synthase based on sequence similarity but purified protein does not possess this activity, nor does it bind flavin mononucleotide (FMN); null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004448","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR456W"}


id: YLR457C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NBP1","product":"Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004449","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR457C"}


id: YLR458W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1/YLR457C gene required for mitosis","secondary_identifier":"SGD:S000004450","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR458W"}


id: YLR459W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02776":null,"YLR459W":null},"has_protein_features":false,"name":"GAB1","ortholog_annotations":[{"gene_uniquename":"YLR459W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02776","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the glycosylphosphatidylinositol transamidase complex; involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or the lipid portion of GPI; ortholog of human PIGU; partially complements a class U CHO cell line with a mutation in the PIGU ortholog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004451","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR459W"}


id: YLR460C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Member of the quinone oxidoreductase family; up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine","secondary_identifier":"SGD:S000004452","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR460C"}


id: YLR461W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU4","product":"Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme","secondary_identifier":"SGD:S000004453","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR461W"}


id: YLR462W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function with similarity to helicases; YLR462W is within the telomere on the right arm of chromosome XII","secondary_identifier":"SGD:S000004454","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR462W"}


id: YLR463C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORFs YLR462W and YLR464W","secondary_identifier":"SGD:S000004455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR463C"}


id: YLR464W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; intron is predicted but not detected experimentally; YLR464W overlaps the verified gene YRF1-4/YLR466W and two dubious ORFs YLR463C and YLR465C","secondary_identifier":"SGD:S000004456","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR464W"}


id: YLR465C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BSC3","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 100% of YLR465C overlaps the uncharacterized ORF YLR464W and 86% of YLR465C overlaps the verified gene YRF1-4","secondary_identifier":"SGD:S000004457","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR465C"}


id: YLR466C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YRF1-4/YLR466W","secondary_identifier":"SGD:S000028685","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR466C-A"}


id: YLR466C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000028686","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR466C-B"}


id: YLR466W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YRF1-4","product":"Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p","secondary_identifier":"SGD:S000004458","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR466W"}


id: YLR467C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YRF1-4/YLR466W","secondary_identifier":"SGD:S000028687","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR467C-A"}


id: YLR467W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YRF1-5","product":"Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p","secondary_identifier":"SGD:S000004459","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR467W"}


id: YML001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03072":null,"SJAG_03137":null,"YML001W":null},"has_protein_features":false,"name":"YPT7","ortholog_annotations":[{"gene_uniquename":"YML001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03072","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03137","reference_uniquename":"PMID:29761456"}],"product":"Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004460","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML001W"}


id: YML002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01309":null,"YML002W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YML002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01309","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; expression induced by heat and by calcium shortage; in many strains, YML002W is continuous with YML003W, and is predicted to encode a single protein of 1090 aa with a full-length VPS9 domain; in strains S288C, W303, and CEN.PK, a single thymine residue is deleted near the 3' end of YML003W at ChrXIII:264337, causing a frameshift and premature stop codon, truncating YML003W","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004461","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML002W"}


id: YML003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01309":null,"YML003W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YML003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01309","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; in many strains, YML002W is continuous with YML003W, and is predicted to encode a single protein of 1090 aa with a full-length VPS9 domain; in strains S288C, W303, and CEN.PK, a single thymine residue is deleted near the 3' end of YML003W at ChrXIII:264337, causing a frameshift and premature stop codon, truncating YML003W","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004462","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML003W"}


id: YML004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04726":null,"YML004C":null},"has_protein_features":false,"name":"GLO1","ortholog_annotations":[{"gene_uniquename":"YML004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04726","reference_uniquename":"PMID:29761456"}],"product":"Monomeric glyoxalase I; catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; required for full activity of O-acetyl homoserine sulfhydrylase, Met17p; expression regulated by methylglyoxal levels and osmotic stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004463","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML004C"}


id: YML005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04735":null,"YML005W":null},"has_protein_features":false,"name":"TRM12","ortholog_annotations":[{"gene_uniquename":"YML005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04735","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine-dependent methyltransferase; required for wybutosine formation in phenylalanine-accepting tRNA; member of the seven beta-strand family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004464","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML005W"}


id: YML006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GIS4","product":"CAAX box containing protein of unknown function; proposed to be involved in the RAS/cAMP signaling pathway","secondary_identifier":"SGD:S000004465","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML006C"}


id: YML007C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIN4","product":"Mitochondrial protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria","secondary_identifier":"SGD:S000007621","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML007C-A"}


id: YML007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04036":null,"YML007W":null},"has_protein_features":false,"name":"YAP1","ortholog_annotations":[{"gene_uniquename":"YML007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04036","reference_uniquename":"PMID:29761456"}],"product":"Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; relative distribution to the nucleus increases upon DNA replication stress; YAP1 has a paralog, CAD1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004466","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML007W"}


id: YML008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03531":null,"YML008C":null},"has_protein_features":false,"name":"ERG6","ortholog_annotations":[{"gene_uniquename":"YML008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03531","reference_uniquename":"PMID:29761456"}],"product":"Delta(24)-sterol C-methyltransferase; converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to lipid particles, the plasma membrane-associated endoplasmic reticulum, and the mitochondrial outer membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004467","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML008C"}


id: YML009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02836":null,"YML009C":null},"has_protein_features":false,"name":"MRPL39","ortholog_annotations":[{"gene_uniquename":"YML009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02836","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004468","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML009C"}


id: YML009C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORFs SPT5/YML010W and YML009W-B","secondary_identifier":"SGD:S000004469","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML009C-A"}


id: YML009W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition","secondary_identifier":"SGD:S000004471","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML009W-B"}


id: YML010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02097":null,"YML010W":null},"has_protein_features":false,"name":"SPT5","ortholog_annotations":[{"gene_uniquename":"YML010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02097","reference_uniquename":"PMID:29761456"}],"product":"Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and in concert with RNAP I and II has multiple roles regulating transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; interacts with DNA upstream of RNAPII and the non-template strand of the transcription bubble; Spt5p is the only transcription elongation factor conserved in all domains of life","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004470","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML010W"}


id: YML011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RAD33","product":"Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus","secondary_identifier":"SGD:S000004472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML011C"}


id: YML012C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1","secondary_identifier":"SGD:S000004474","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML012C-A"}


id: YML012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00357":null,"YML012W":null},"has_protein_features":false,"name":"ERV25","ortholog_annotations":[{"gene_uniquename":"YML012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00357","reference_uniquename":"PMID:29761456"}],"product":"Member of the p24 family involved in ER to Golgi transport; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1, Erp2p, and Emp24,","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004473","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML012W"}


id: YML013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01585":null,"YML013W":null},"has_protein_features":false,"name":"UBX2","ortholog_annotations":[{"gene_uniquename":"YML013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01585","reference_uniquename":"PMID:29761456"}],"product":"Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis; required for mitochondrial protein translocation-associated degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004475","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML013W"}


id: YML014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02042":null,"YML014W":null},"has_protein_features":false,"name":"TRM9","ortholog_annotations":[{"gene_uniquename":"YML014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02042","reference_uniquename":"PMID:29761456"}],"product":"tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004476","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML014W"}


id: YML015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03285":null,"YML015C":null},"has_protein_features":false,"name":"TAF11","ortholog_annotations":[{"gene_uniquename":"YML015C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03285","reference_uniquename":"PMID:29761456"}],"product":"TFIID subunit (40 kDa); involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004477","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML015C"}


id: YML016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04426":null,"YML016C":null},"has_protein_features":false,"name":"PPZ1","ortholog_annotations":[{"gene_uniquename":"YML016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04426","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004478","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML016C"}


id: YML017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PSP2","product":"Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing","secondary_identifier":"SGD:S000004479","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML017W"}


id: YML018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03138":null,"YML018C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YML018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03138","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004480","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML018C"}


id: YML019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03333":null,"YML019W":null},"has_protein_features":false,"name":"OST6","ortholog_annotations":[{"gene_uniquename":"YML019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03333","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004481","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML019W"}


id: YML020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03134":null,"YML020W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YML020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03134","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004482","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML020W"}


id: YML021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02528":null,"YML021C":null},"has_protein_features":false,"name":"UNG1","ortholog_annotations":[{"gene_uniquename":"YML021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02528","reference_uniquename":"PMID:29761456"}],"product":"Uracil-DNA glycosylase; required for repair of uracil in DNA formed by spontaneous cytosine deamination; efficiently excises uracil from single-stranded DNA in vivo; not required for strand-specific mismatch repair; cell-cycle regulated, expressed in late G1; localizes to mitochondria and nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004483","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML021C"}


id: YML022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01859":null,"YML022W":null},"has_protein_features":false,"name":"APT1","ortholog_annotations":[{"gene_uniquename":"YML022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01859","reference_uniquename":"PMID:29761456"}],"product":"Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004484","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML022W"}


id: YML023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04932":null,"YML023C":null},"has_protein_features":false,"name":"NSE5","ortholog_annotations":[{"gene_uniquename":"YML023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04932","reference_uniquename":"PMID:29761456"}],"product":"Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004485","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML023C"}


id: YML024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04168":null,"SJAG_04204":null,"YML024W":null},"has_protein_features":false,"name":"RPS17A","ortholog_annotations":[{"gene_uniquename":"YML024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04168","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04204","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004486","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML024W"}


id: YML025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03649":null,"YML025C":null},"has_protein_features":false,"name":"YML6","ortholog_annotations":[{"gene_uniquename":"YML025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03649","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004487","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML025C"}


id: YML026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02861":null,"SJAG_04188":null,"YML026C":null},"has_protein_features":false,"name":"RPS18B","ortholog_annotations":[{"gene_uniquename":"YML026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02861","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04188","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004488","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML026C"}


id: YML027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01157":null,"YML027W":null},"has_protein_features":false,"name":"YOX1","ortholog_annotations":[{"gene_uniquename":"YML027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01157","reference_uniquename":"PMID:29761456"}],"product":"Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; phosphorylated by Cdc28p; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004489","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML027W"}


id: YML028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01199":null,"YML028W":null},"has_protein_features":false,"name":"TSA1","ortholog_annotations":[{"gene_uniquename":"YML028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01199","reference_uniquename":"PMID:29761456"}],"product":"Thioredoxin peroxidase; acts as both ribosome-associated and free cytoplasmic antioxidant; self-associates to form a HMW chaperone complex under oxidative stress; chaperone activity essential for growth in zinc deficiency; hydrogen peroxide receptor and signal transducer in a light sensing pathway; required for telomere length maintenance; binds and modulates Cdc19p activity; protein abundance increases and forms cytoplasmic foci during DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004490","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML028W"}


id: YML029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"USA1","product":"Scaffold subunit of the Hrd1p ubiquitin ligase; also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p","secondary_identifier":"SGD:S000004491","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML029W"}


id: YML030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02975":null,"YML030W":null},"has_protein_features":false,"name":"RCF1","ortholog_annotations":[{"gene_uniquename":"YML030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02975","reference_uniquename":"PMID:29761456"}],"product":"Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004492","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML030W"}


id: YML031C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF NDC1/YML031W","secondary_identifier":"SGD:S000028809","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML031C-A"}


id: YML031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03200":null,"YML031W":null},"has_protein_features":false,"name":"NDC1","ortholog_annotations":[{"gene_uniquename":"YML031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03200","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004493","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML031W"}


id: YML032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02079":null,"SJAG_04530":null,"YML032C":null},"has_protein_features":false,"name":"RAD52","ortholog_annotations":[{"gene_uniquename":"YML032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02079","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04530","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in homologous recombination; attenuates resection of DNA double-strand break ends and stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis and UV induced sister chromatid recombination; phosphorylation by Cdc28p in G2/M phase promotes Rad52p ring interaction that leads to superstructure formation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004494","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML032C"}


id: YML033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YML033W was originally annotated as an independent ORF, but was later demonstrated to be an exon of an adjacent ORF, YML034W","secondary_identifier":"SGD:S000082441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML033W"}


id: YML034C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SRC1/YML034W","secondary_identifier":"SGD:S000004499","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML034C-A"}


id: YML034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01745":null,"SJAG_03449":null,"YML034W":null},"has_protein_features":false,"name":"SRC1","ortholog_annotations":[{"gene_uniquename":"YML034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01745","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03449","reference_uniquename":"PMID:29761456"}],"product":"Inner nuclear membrane protein; highly enriched at telomeres and subtelomeric regions; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance; SRC1 has a paralog, HEH2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004497","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML034W"}


id: YML035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04123":null,"YML035C":null},"has_protein_features":false,"name":"AMD1","ortholog_annotations":[{"gene_uniquename":"YML035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04123","reference_uniquename":"PMID:29761456"}],"product":"AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004498","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML035C"}


id: YML036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04201":null,"YML036W":null},"has_protein_features":false,"name":"CGI121","ortholog_annotations":[{"gene_uniquename":"YML036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04201","reference_uniquename":"PMID:29761456"}],"product":"Component of the EKC/KEOPS complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; Cgi121p is dispensable for tRNA modification; other complex members are Bud32p, Kae1p, Pcc1p, and Gon7p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004500","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML036W"}


id: YML037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; has some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene","secondary_identifier":"SGD:S000004501","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML037C"}


id: YML038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04406":null,"YML038C":null},"has_protein_features":false,"name":"YMD8","ortholog_annotations":[{"gene_uniquename":"YML038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04406","reference_uniquename":"PMID:29761456"}],"product":"Putative nucleotide sugar transporter; has similarity to Vrg4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004502","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML038C"}


id: YML041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05192":null,"YML041C":null},"has_protein_features":false,"name":"VPS71","ortholog_annotations":[{"gene_uniquename":"YML041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05192","reference_uniquename":"PMID:29761456"}],"product":"Nucleosome-binding component of the SWR1 complex; SWR1 exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004505","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML041C"}


id: YML042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CAT2","product":"Carnitine acetyl-CoA transferase; present in both mitochondria and peroxisomes; transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes","secondary_identifier":"SGD:S000004506","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML042W"}


id: YML043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00692":null,"YML043C":null},"has_protein_features":false,"name":"RRN11","ortholog_annotations":[{"gene_uniquename":"YML043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00692","reference_uniquename":"PMID:29761456"}],"product":"Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004507","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML043C"}


id: YML046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00058":null,"YML046W":null},"has_protein_features":false,"name":"PRP39","ortholog_annotations":[{"gene_uniquename":"YML046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00058","reference_uniquename":"PMID:29761456"}],"product":"U1 snRNP protein involved in splicing; contains multiple tetriatricopeptide repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004509","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML046W"}


id: YML047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRM6","product":"Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; member of a fungal-specific gene family; PRM6 has a paralog, KCH1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004510","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML047C"}


id: YML047W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF PRM6/YML047C","secondary_identifier":"SGD:S000004512","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML047W-A"}


id: YML048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GSF2","product":"Endoplasmic reticulum (ER) localized integral membrane protein; may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression","secondary_identifier":"SGD:S000004511","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML048W"}


id: YML049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02185":null,"YML049C":null},"has_protein_features":false,"name":"RSE1","ortholog_annotations":[{"gene_uniquename":"YML049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02185","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004513","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML049C"}


id: YML050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM32","product":"2Fe-2S mitochondrial protein involved in redox quality control; may maintain protein redox status by targeting oxidation sensitive cysteine residues; bishistidinyl coordinated, non-Rieske [2Fe-2S] cluster containing thiredoxin-like ferredoxin; forms a functional complex with Osm1p and Erv1p in the IMS; required for assembly of numerous mitochondrial import complexes; essential for anaerobiosis; localizes to the mitochondrial matrix and intermembrane space (IMS); homologous to APD1","secondary_identifier":"SGD:S000004514","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML050W"}


id: YML051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GAL80","product":"Transcriptional regulator involved in the repression of GAL genes; involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding","secondary_identifier":"SGD:S000004515","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML051W"}


id: YML052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SUR7","product":"Plasma membrane protein, component of eisosomes; long-lived protein that remains stable in eisosomes of mother cells while other eisosome proteins, Pil1p and Lsp1p, turn over; may function to anchor the eisosome in place; sporulation and plasma membrane sphingolipid content are altered in mutants; localizes to furrow-like invaginations (MCC patches)","secondary_identifier":"SGD:S000004516","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML052W"}


id: YML053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene","secondary_identifier":"SGD:S000004517","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML053C"}


id: YML054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CYB2","product":"Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions","secondary_identifier":"SGD:S000004518","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML054C"}


id: YML054C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028573","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML054C-A"}


id: YML055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02867":null,"YML055W":null},"has_protein_features":false,"name":"SPC2","ortholog_annotations":[{"gene_uniquename":"YML055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02867","reference_uniquename":"PMID:29761456"}],"product":"Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; inhibits SRP-independent translocation into the ER with STE24; homologous to mammalian SPC25; other members of the complex are Spc1p, Spc1p, and Sec11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004519","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML055W"}


id: YML056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01298":null,"YML056C":null},"has_protein_features":false,"name":"IMD4","ortholog_annotations":[{"gene_uniquename":"YML056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01298","reference_uniquename":"PMID:29761456"}],"product":"Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD4 has a paralog, IMD3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004520","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML056C"}


id: YML057C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W","secondary_identifier":"SGD:S000004522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML057C-A"}


id: YML057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03631":null,"YML057W":null},"has_protein_features":false,"name":"CMP2","ortholog_annotations":[{"gene_uniquename":"YML057W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03631","reference_uniquename":"PMID:29761456"}],"product":"Calcineurin A; one isoform (the other is Cna1p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CMP2 has a paralog, CNA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML057W"}


id: YML058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SML1","product":"Ribonucleotide reductase inhibitor; involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; SML1 has a paralog, DIF1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML058W"}


id: YML058W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HUG1","product":"Ribonucleotide reductase inhibitor; intrinsically disordered protein that binds to and inhibits Rnr2p; involved in the Mec1p-mediated checkpoint pathway; transcription is induced by genotoxic stress and by activation of the Rad53p pathway; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000007472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML058W-A"}


id: YML059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04110":null,"YML059C":null},"has_protein_features":false,"name":"NTE1","ortholog_annotations":[{"gene_uniquename":"YML059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04110","reference_uniquename":"PMID:29761456"}],"product":"Serine esterase; homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004524","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML059C"}


id: YML060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01119":null,"YML060W":null},"has_protein_features":false,"name":"OGG1","ortholog_annotations":[{"gene_uniquename":"YML060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01119","reference_uniquename":"PMID:26896847"}],"product":"Nuclear and mitochondrial glycosylase/lyase; specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004525","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML060W"}


id: YML061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03780":null,"YML061C":null},"has_protein_features":false,"name":"PIF1","ortholog_annotations":[{"gene_uniquename":"YML061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03780","reference_uniquename":"PMID:29761456"}],"product":"DNA helicase, potent G-quadruplex DNA binder/unwinder; possesses strand annealing activity; promotes DNA synthesis during break-induced replication; involved in crossover recombination; works with Hrq1p to maintain telomere length homeostasis; translation from different start sites produces mitochondrial (DNA repair and recombination) and nuclear (catalytic inhibitor of telomerase) forms; mutations affect Zn, Fe homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML061C"}


id: YML062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04202":null,"YML062C":null},"has_protein_features":false,"name":"MFT1","ortholog_annotations":[{"gene_uniquename":"YML062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04202","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the THO complex; THO is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004527","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML062C"}


id: YML063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00733":null,"SJAG_02522":null,"YML063W":null},"has_protein_features":false,"name":"RPS1B","ortholog_annotations":[{"gene_uniquename":"YML063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00733","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02522","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004528","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML063W"}


id: YML064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03342":null,"YML064C":null},"has_protein_features":false,"name":"TEM1","ortholog_annotations":[{"gene_uniquename":"YML064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03342","reference_uniquename":"PMID:29761456"}],"product":"GTPase involved in initiation of Mitotic Exit Network (MEN); GTP-binding protein of the Ras superfamily; accumulates at daughter spindle pole body and activates MEN kinase cascade; controls actomyosin and septin dynamics during cytokinesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004529","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML064C"}


id: YML065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03927":null,"YML065W":null},"has_protein_features":false,"name":"ORC1","ortholog_annotations":[{"gene_uniquename":"YML065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03927","reference_uniquename":"PMID:29761456"}],"product":"Largest subunit of the origin recognition complex; involved in directing DNA replication by binding to replication origins; also involved in transcriptional silencing; exhibits ATPase activity; ORC1 has a paralog, SIR3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004530","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML065W"}


id: YML066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SMA2","product":"Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation","secondary_identifier":"SGD:S000004531","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML066C"}


id: YML067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03933":null,"YML067C":null},"has_protein_features":false,"name":"ERV41","ortholog_annotations":[{"gene_uniquename":"YML067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03933","reference_uniquename":"PMID:29761456"}],"product":"Protein localized to COPII-coated vesicles; forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004532","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML067C"}


id: YML068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ITT1","product":"Protein that modulates the efficiency of translation termination; interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins","secondary_identifier":"SGD:S000004533","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML068W"}


id: YML069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03128":null,"YML069W":null},"has_protein_features":false,"name":"POB3","ortholog_annotations":[{"gene_uniquename":"YML069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03128","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004534","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML069W"}


id: YML070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04320":null,"YML070W":null},"has_protein_features":false,"name":"DAK1","ortholog_annotations":[{"gene_uniquename":"YML070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04320","reference_uniquename":"PMID:29761456"}],"product":"Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004535","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML070W"}


id: YML071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03054":null,"YML071C":null},"has_protein_features":false,"name":"COG8","ortholog_annotations":[{"gene_uniquename":"YML071C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03054","reference_uniquename":"PMID:29761456"}],"product":"Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004536","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML071C"}


id: YML072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01437":null,"SJAG_04413":null,"SJAG_04417":null,"YML072C":null},"has_protein_features":false,"name":"TCB3","ortholog_annotations":[{"gene_uniquename":"YML072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01437","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04413","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04417","reference_uniquename":"PMID:29761456"}],"product":"Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004537","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML072C"}


id: YML073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03666":null,"YML073C":null},"has_protein_features":false,"name":"RPL6A","ortholog_annotations":[{"gene_uniquename":"YML073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03666","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004538","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML073C"}


id: YML074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01005":null,"SJAG_03905":null,"YML074C":null},"has_protein_features":false,"name":"FPR3","ortholog_annotations":[{"gene_uniquename":"YML074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01005","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03905","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; affects expression of multiple genes via its role in nucleosome assembly; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; FPR3 has a paralog, FPR4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004539","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML074C"}


id: YML075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03715":null,"YML075C":null},"has_protein_features":false,"name":"HMG1","ortholog_annotations":[{"gene_uniquename":"YML075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03715","reference_uniquename":"PMID:29761456"}],"product":"HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004540","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML075C"}


id: YML076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"WAR1","product":"Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively","secondary_identifier":"SGD:S000004541","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML076C"}


id: YML077W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04837":null,"YML077W":null},"has_protein_features":false,"name":"BET5","ortholog_annotations":[{"gene_uniquename":"YML077W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04837","reference_uniquename":"PMID:29761456"}],"product":"Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); human homology TRAPPC1 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004542","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML077W"}


id: YML078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01246":null,"YML078W":null},"has_protein_features":false,"name":"CPR3","ortholog_annotations":[{"gene_uniquename":"YML078W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01246","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004543","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML078W"}


id: YML079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Non-essential protein of unknown function; has structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm","secondary_identifier":"SGD:S000004544","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML079W"}


id: YML080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00174":null,"YML080W":null},"has_protein_features":false,"name":"DUS1","ortholog_annotations":[{"gene_uniquename":"YML080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00174","reference_uniquename":"PMID:29761456"}],"product":"Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004545","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML080W"}


id: YML081C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02105":null,"YML081C-A":null},"has_protein_features":false,"name":"ATP18","ortholog_annotations":[{"gene_uniquename":"YML081C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02105","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML081C-A"}


id: YML081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03346":null,"YML081W":null},"has_protein_features":false,"name":"TDA9","ortholog_annotations":[{"gene_uniquename":"YML081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03346","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor that regulates acetate production; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004546","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML081W"}


id: YML082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03102":null,"YML082W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YML082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03102","reference_uniquename":"PMID:29761456"}],"product":"Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; not an essential gene; YML082W has a paralog, STR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004547","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML082W"}


id: YML083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions","secondary_identifier":"SGD:S000004548","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML083C"}


id: YML084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004549","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML084W"}


id: YML085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02509":null,"SJAG_04387":null,"YML085C":null},"has_protein_features":false,"name":"TUB1","ortholog_annotations":[{"gene_uniquename":"YML085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02509","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04387","reference_uniquename":"PMID:29761456"}],"product":"Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004550","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML085C"}


id: YML086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00265":null,"YML086C":null},"has_protein_features":false,"name":"ALO1","ortholog_annotations":[{"gene_uniquename":"YML086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00265","reference_uniquename":"PMID:29761456"}],"product":"D-Arabinono-1,4-lactone oxidase; catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004551","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML086C"}


id: YML087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM33","product":"Protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004552","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML087C"}


id: YML088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01617":null,"YML088W":null},"has_protein_features":false,"name":"UFO1","ortholog_annotations":[{"gene_uniquename":"YML088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01617","reference_uniquename":"PMID:29761456"}],"product":"F-box receptor protein; subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitination by SCF and subsequent degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004553","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML088W"}


id: YML089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage","secondary_identifier":"SGD:S000004554","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML089C"}


id: YML090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source","secondary_identifier":"SGD:S000004555","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML090W"}


id: YML091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RPM2","product":"Protein subunit of mitochondrial RNase P; has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus","secondary_identifier":"SGD:S000004556","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML091C"}


id: YML092C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02502":null,"YML092C":null},"has_protein_features":false,"name":"PRE8","ortholog_annotations":[{"gene_uniquename":"YML092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02502","reference_uniquename":"PMID:29761456"}],"product":"Alpha 2 subunit of the 20S proteasome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004557","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML092C"}


id: YML093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04424":null,"YML093W":null},"has_protein_features":false,"name":"UTP14","ortholog_annotations":[{"gene_uniquename":"YML093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04424","reference_uniquename":"PMID:29761456"}],"product":"Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004558","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML093W"}


id: YML094C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO","secondary_identifier":"SGD:S000004561","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML094C-A"}


id: YML094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04012":null,"YML094W":null},"has_protein_features":false,"name":"GIM5","ortholog_annotations":[{"gene_uniquename":"YML094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04012","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004559","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML094W"}


id: YML095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02828":null,"YML095C":null},"has_protein_features":false,"name":"RAD10","ortholog_annotations":[{"gene_uniquename":"YML095C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02828","reference_uniquename":"PMID:29761456"}],"product":"Single-stranded DNA endonuclease (with Rad1p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004560","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML095C"}


id: YML096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02832":null,"YML096W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YML096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02832","reference_uniquename":"PMID:29761456"}],"product":"Putative protein with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004562","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML096W"}


id: YML097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02833":null,"YML097C":null},"has_protein_features":false,"name":"VPS9","ortholog_annotations":[{"gene_uniquename":"YML097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02833","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF) and ubiquitin receptor; involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); stimulates the intrinsic guanine nucleotide exchange activity of Rab family members (Vps21p/Ypt52p/Ypt53p); partially redundant with GEF MUK1; required for localization of the CORVET complex to endosomes; similar to mammalian ras inhibitors; contains a Ub-interacting CUE domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004563","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML097C"}


id: YML098W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04654":null,"YML098W":null},"has_protein_features":false,"name":"TAF13","ortholog_annotations":[{"gene_uniquename":"YML098W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04654","reference_uniquename":"PMID:29761456"}],"product":"TFIID subunit (19 kDa); involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004564","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML098W"}


id: YML099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ARG81","product":"Zinc finger transcription factor involved in arginine-responsive genes; Zn(2)-Cys(6) binuclear cluster domain type; involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p","secondary_identifier":"SGD:S000004565","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML099C"}


id: YML099W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ARG81/YML099C","secondary_identifier":"SGD:S000004567","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML099W-A"}


id: YML100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00129":null,"SJAG_00182":null,"SJAG_01427":null,"YML100W":null},"has_protein_features":false,"name":"TSL1","ortholog_annotations":[{"gene_uniquename":"YML100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00129","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00182","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YML100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01427","reference_uniquename":"PMID:29761456"}],"product":"Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; contributes to survival to acute lethal heat stress; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML100W"}


id: YML100W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028688","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML100W-A"}


id: YML101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01051":null,"YML101C":null},"has_protein_features":false,"name":"CUE4","ortholog_annotations":[{"gene_uniquename":"YML101C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01051","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004568","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML101C"}


id: YML101C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004569","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML101C-A"}


id: YML102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02198":null,"YML102W":null},"has_protein_features":false,"name":"CAC2","ortholog_annotations":[{"gene_uniquename":"YML102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02198","reference_uniquename":"PMID:29761456"}],"product":"Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure, deactivation of the DNA damage checkpoint after DNA repair, chromatin dynamics during transcription; and repression of divergent transcription; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004570","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML102W"}


id: YML103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00375":null,"YML103C":null},"has_protein_features":false,"name":"NUP188","ortholog_annotations":[{"gene_uniquename":"YML103C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00375","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004571","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML103C"}


id: YML104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04221":null,"YML104C":null},"has_protein_features":false,"name":"MDM1","ortholog_annotations":[{"gene_uniquename":"YML104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04221","reference_uniquename":"PMID:29761456"}],"product":"PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs; anchored in the ER membrane at nucleus-vacuole junctions and binds phosphatidylinositol 3-phosphate (PtdIns-3-P) in the vacuolar membrane via its Phox homology (PX) domain; expressed predominantly in late G1 to early S phase of the cell cycle; mutation affects nuclear and mitochondrial transmission to daughter buds; similar to 4 human genes, one of which (SNX14) is associated with neurological disease","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004572","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML104C"}


id: YML105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02456":null,"YML105C":null},"has_protein_features":false,"name":"SEC65","ortholog_annotations":[{"gene_uniquename":"YML105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02456","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the signal recognition particle (SRP); involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004573","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML105C"}


id: YML106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00694":null,"YML106W":null},"has_protein_features":false,"name":"URA5","ortholog_annotations":[{"gene_uniquename":"YML106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00694","reference_uniquename":"PMID:29761456"}],"product":"Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004574","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML106W"}


id: YML107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05243":null,"YML107C":null},"has_protein_features":false,"name":"PML39","ortholog_annotations":[{"gene_uniquename":"YML107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05243","reference_uniquename":"PMID:29761456"}],"product":"Protein required for nuclear retention of unspliced pre-mRNAs; required along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004575","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML107C"}


id: YML108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000004576","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML108W"}


id: YML109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01901":null,"YML109W":null},"has_protein_features":false,"name":"ZDS2","ortholog_annotations":[{"gene_uniquename":"YML109W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01901","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004577","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML109W"}


id: YML110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01043":null,"YML110C":null},"has_protein_features":false,"name":"COQ5","ortholog_annotations":[{"gene_uniquename":"YML110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01043","reference_uniquename":"PMID:29761456"}],"product":"2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; respiratory defect of the null mutant is partially complemented by human COQ5","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004578","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML110C"}


id: YML111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUL2","product":"Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex; ubiquitin-binding adaptor involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004579","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML111W"}


id: YML112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01149":null,"YML112W":null},"has_protein_features":false,"name":"CTK3","ortholog_annotations":[{"gene_uniquename":"YML112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01149","reference_uniquename":"PMID:29761456"}],"product":"Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004580","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML112W"}


id: YML113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DAT1","product":"DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; relocalizes to the cytosol in response to hypoxia; not essential for viability","secondary_identifier":"SGD:S000004581","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML113W"}


id: YML114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00872":null,"YML114C":null},"has_protein_features":false,"name":"TAF8","ortholog_annotations":[{"gene_uniquename":"YML114C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00872","reference_uniquename":"PMID:29761456"}],"product":"TFIID subunit (65 kDa); involved in RNA polymerase II transcription initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004582","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML114C"}


id: YML115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00816":null,"YML115C":null},"has_protein_features":false,"name":"VAN1","ortholog_annotations":[{"gene_uniquename":"YML115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00816","reference_uniquename":"PMID:29761456"}],"product":"Component of the mannan polymerase I; complex contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004583","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML115C"}


id: YML116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATR1","product":"Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004584","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML116W"}


id: YML116W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000004586","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML116W-A"}


id: YML117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03498":null,"YML117W":null},"has_protein_features":false,"name":"NAB6","ortholog_annotations":[{"gene_uniquename":"YML117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03498","reference_uniquename":"PMID:26896847"}],"product":"Putative RNA-binding protein; associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004585","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML117W"}


id: YML118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04519":null,"YML118W":null},"has_protein_features":false,"name":"NGL3","ortholog_annotations":[{"gene_uniquename":"YML118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04519","reference_uniquename":"PMID:29761456"}],"product":"3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML118W"}


id: YML119W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate","secondary_identifier":"SGD:S000004588","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML119W"}


id: YML120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04152":null,"YML120C":null},"has_protein_features":false,"name":"NDI1","ortholog_annotations":[{"gene_uniquename":"YML120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04152","reference_uniquename":"PMID:29761456"}],"product":"NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in respiratory chain but does not pump protons, in contrast to higher eukaryotic multisubunit respiratory complex I; upon apoptotic stress, is activated in mitochondria by N-terminal cleavage, then translocates to cytoplasm to induce apoptosis; homolog of human AIFM2; yeast NDI1 complements several phenotypes of human cell line with mutated MT-ND4, implicated in Leber hereditary optic neuropathy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004589","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML120C"}


id: YML121W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00457":null,"YML121W":null},"has_protein_features":false,"name":"GTR1","ortholog_annotations":[{"gene_uniquename":"YML121W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00457","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex; subunit of Gtr1-Gtr2, a GTPase that activates TORC1 in response to amino acid stimulation; subunit of EGO/GSE, a vacuolar/endosomal membrane complex that regulates exit from rapamycin-induced growth arrest and sorting of Gap1p from the endosome to the plasma membrane; involved in phosphate transport and telomeric chromatin silencing; activated by the the Iml1p (GAP) subunit of the SEACIT complex; similar to human RagA and RagB","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004590","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML121W"}


id: YML122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YML122C is not an essential gene","secondary_identifier":"SGD:S000004591","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML122C"}


id: YML123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01033":null,"SJAG_04241":null,"YML123C":null},"has_protein_features":false,"name":"PHO84","ortholog_annotations":[{"gene_uniquename":"YML123C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01033","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML123C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04241","reference_uniquename":"PMID:29761456"}],"product":"High-affinity inorganic phosphate (Pi) transporter; also low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004592","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML123C"}


id: YML124C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02509":null,"SJAG_04387":null,"YML124C":null},"has_protein_features":false,"name":"TUB3","ortholog_annotations":[{"gene_uniquename":"YML124C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02509","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML124C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04387","reference_uniquename":"PMID:29761456"}],"product":"Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004593","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML124C"}


id: YML125C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PGA3","product":"Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004594","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML125C"}


id: YML126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04499":null,"YML126C":null},"has_protein_features":false,"name":"ERG13","ortholog_annotations":[{"gene_uniquename":"YML126C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04499","reference_uniquename":"PMID:29761456"}],"product":"3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase; catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004595","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML126C"}


id: YML127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01622":null,"YML127W":null},"has_protein_features":false,"name":"RSC9","ortholog_annotations":[{"gene_uniquename":"YML127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01622","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004596","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML127W"}


id: YML128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00680":null,"SJAG_03837":null,"YML128C":null},"has_protein_features":false,"name":"MSC1","ortholog_annotations":[{"gene_uniquename":"YML128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00680","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03837","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004597","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML128C"}


id: YML129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02480":null,"YML129C":null},"has_protein_features":false,"name":"COX14","ortholog_annotations":[{"gene_uniquename":"YML129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02480","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial cytochrome c oxidase (complex IV) assembly factor; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; located in the mitochondrial membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004598","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML129C"}


id: YML130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02489":null,"SJAG_02827":null,"YML130C":null},"has_protein_features":false,"name":"ERO1","ortholog_annotations":[{"gene_uniquename":"YML130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02489","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02827","reference_uniquename":"PMID:29761456"}],"product":"Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining ER redox balance; feedback regulated via reduction and oxidation of regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds; ero1-1 mutation complemented by human ERO1L","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004599","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML130C"}


id: YML131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01362":null,"SJAG_02151":null,"YML131W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YML131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01362","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02151","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004600","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML131W"}


id: YML132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS3","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000004601","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML132W"}


id: YML133C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative Y' element ATP-dependent helicase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron","secondary_identifier":"SGD:S000004602","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML133C"}


id: YML133W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YML133C","secondary_identifier":"SGD:S000028689","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML133W-A"}


id: YML133W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YML133C","secondary_identifier":"SGD:S000028690","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML133W-B"}


id: YMR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01805":null,"YMR001C":null},"has_protein_features":false,"name":"CDC5","ortholog_annotations":[{"gene_uniquename":"YMR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01805","reference_uniquename":"PMID:29761456"}],"product":"Polo-like kinase essential for mitotic cell cycle; controls targeting, activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates shape of nucleus, expansion of nuclear envelope during mitosis; implicated in cell divisions in telomerase-negative strains through adaptation to DNA damage, which allows bypass of cell cycle arrest and contributes senescence-specific genome instability; human homologs PLK1, PLK3 can each complement cdc5 thermosensitive mutants","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004603","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR001C"}


id: YMR001C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028691","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR001C-A"}


id: YMR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIX17","product":"Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004604","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR002W"}


id: YMR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM34","product":"Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss","secondary_identifier":"SGD:S000004605","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR003W"}


id: YMR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MVP1","product":"Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with 'foot domain' of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004606","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR004W"}


id: YMR005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00741":null,"YMR005W":null},"has_protein_features":false,"name":"TAF4","ortholog_annotations":[{"gene_uniquename":"YMR005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00741","reference_uniquename":"PMID:29761456"}],"product":"TFIID subunit (48 kDa); involved in RNA polymerase II transcription initiation; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004607","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR005W"}


id: YMR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02091":null,"SJAG_02093":null,"SJAG_03204":null,"YMR006C":null},"has_protein_features":false,"name":"PLB2","ortholog_annotations":[{"gene_uniquename":"YMR006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02091","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02093","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03204","reference_uniquename":"PMID:29761456"}],"product":"Phospholipase B (lysophospholipase) involved in lipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR006C"}


id: YMR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YMR007W is not an essential gene","secondary_identifier":"SGD:S000004609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR007W"}


id: YMR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02091":null,"SJAG_02093":null,"SJAG_03204":null,"YMR008C":null},"has_protein_features":false,"name":"PLB1","ortholog_annotations":[{"gene_uniquename":"YMR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02091","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02093","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03204","reference_uniquename":"PMID:29761456"}],"product":"Phospholipase B (lysophospholipase) involved in lipid metabolism; required for efficient acyl chain remodeling of newly synthesized phosphatidylethanolamine-derived phosphatidylcholine; required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol; PLB1 has a paralog, PLB3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004610","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR008C"}


id: YMR008C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Novel ORF identified via pan-genome analysis; conserved in other strains of S. cerevisiae","secondary_identifier":"SGD:S000303813","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR008C-A"}


id: YMR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00309":null,"YMR009W":null},"has_protein_features":false,"name":"ADI1","ortholog_annotations":[{"gene_uniquename":"YMR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00309","reference_uniquename":"PMID:29761456"}],"product":"Acireductone dioxygenease involved in methionine salvage pathway; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions; human ortholog ADI1 can complement yeast adi1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004611","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR009W"}


id: YMR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ANY1","product":"Protein involved in phospholipid flippase function; null allele suppresses growth and membrane trafficking defects associated with all flippase null alleles; proposed function as a phospholipid scramblase that reduces membrane asymmetry; PQ loop family member; localizes to the endosome and trans-Golgi network; non-essential gene","secondary_identifier":"SGD:S000004612","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR010W"}


id: YMR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YMR011W":null},"has_protein_features":false,"name":"HXT2","ortholog_annotations":[{"gene_uniquename":"YMR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YMR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YMR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR011W"}


id: YMR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01741":null,"YMR012W":null},"has_protein_features":false,"name":"CLU1","ortholog_annotations":[{"gene_uniquename":"YMR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01741","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the eukaryotic translation initiation factor 3 (eIF3); component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation; can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant; eIF3 is also involved in programmed stop codon readthrough","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004614","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR012W"}


id: YMR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04231":null,"YMR013C":null},"has_protein_features":false,"name":"SEC59","ortholog_annotations":[{"gene_uniquename":"YMR013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04231","reference_uniquename":"PMID:29761456"}],"product":"Dolichol kinase; catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004615","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR013C"}


id: YMR013C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF SEC59/YML013C","secondary_identifier":"SGD:S000028847","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR013C-A"}


id: YMR013W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73","secondary_identifier":"SGD:S000007622","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR013W-A"}


id: YMR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01272":null,"YMR014W":null},"has_protein_features":false,"name":"BUD22","ortholog_annotations":[{"gene_uniquename":"YMR014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01272","reference_uniquename":"PMID:29761456"}],"product":"Protein required for rRNA maturation and ribosomal subunit biogenesis; required for 18S rRNA maturation; also required for small ribosomal subunit biogenesis; cosediments with pre-ribosomal particles; mutation decreases efficiency of +1 Ty1 frameshifting and transposition, and affects budding pattern","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004616","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR014W"}


id: YMR015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03249":null,"YMR015C":null},"has_protein_features":false,"name":"ERG5","ortholog_annotations":[{"gene_uniquename":"YMR015C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03249","reference_uniquename":"PMID:29761456"}],"product":"C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004617","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR015C"}


id: YMR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SOK2","product":"Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; relocalizes to the cytosol in response to hypoxia; SOK2 has a paralog, PHD1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004618","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR016C"}


id: YMR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00826":null,"YMR017W":null},"has_protein_features":false,"name":"SPO20","ortholog_annotations":[{"gene_uniquename":"YMR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00826","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific subunit of the t-SNARE complex; required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; binds to phosphatidic acid; SNAP-25 homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR017W"}


id: YMR018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00702":null,"YMR018W":null},"has_protein_features":false,"name":"PEX9","ortholog_annotations":[{"gene_uniquename":"YMR018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00702","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal membrane signal receptor for peroxisomal matrix proteins; oleate-inducible condition-specific import receptor for a subset of PTS1-containing matrix proteins; localizes to both the cytosol and the peroxisomal membrane; similar to human PEX5Rp, a peroxin protein 5 related protein; paralog of Pex5p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004620","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR018W"}


id: YMR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STB4","product":"Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay;","secondary_identifier":"SGD:S000004621","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR019W"}


id: YMR020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMS1","product":"Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis","secondary_identifier":"SGD:S000004622","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR020W"}


id: YMR021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00802":null,"SJAG_01694":null,"YMR021C":null},"has_protein_features":false,"name":"MAC1","ortholog_annotations":[{"gene_uniquename":"YMR021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00802","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01694","reference_uniquename":"PMID:29761456"}],"product":"Copper-sensing transcription factor; involved in regulation of genes required for high affinity copper transport; required for regulation of yeast copper genes in response to DNA-damaging agents; undergoes changes in redox state in response to changing levels of copper or MMS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004623","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR021C"}


id: YMR022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04612":null,"YMR022W":null},"has_protein_features":false,"name":"UBC7","ortholog_annotations":[{"gene_uniquename":"YMR022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04612","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin conjugating enzyme; involved in the ER-associated protein degradation (ERAD) pathway and in the inner nuclear membrane-associated degradation (INMAD) pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004624","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR022W"}


id: YMR023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02302":null,"YMR023C":null},"has_protein_features":false,"name":"MSS1","ortholog_annotations":[{"gene_uniquename":"YMR023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02302","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein; forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004625","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR023C"}


id: YMR024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04019":null,"YMR024W":null},"has_protein_features":false,"name":"MRPL3","ortholog_annotations":[{"gene_uniquename":"YMR024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04019","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; located in close proximity to the polypeptide exit channel of the ribosome; mutations in human homolog MRPL44 cause childhood cardiomyopathy; human MRPL44 deficiency results in inefficient assembly of the mitochondrial ribosome, and in tissue-specific respiratory chain deficiency, manifesting as either Complex I+Complex IV or Complex IV deficiency, depending on a cell type","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR024W"}


id: YMR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSI1","product":"Subunit of the Cop9 signalosome; which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome","secondary_identifier":"SGD:S000004627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR025W"}


id: YMR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03324":null,"YMR026C":null},"has_protein_features":false,"name":"PEX12","ortholog_annotations":[{"gene_uniquename":"YMR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03324","reference_uniquename":"PMID:29761456"}],"product":"C3HC4-type RING-finger peroxin and E3 ubiquitin ligase; required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR026C"}


id: YMR027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04242":null,"YMR027W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YMR027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04242","reference_uniquename":"PMID:29761456"}],"product":"A metal-dependent phosphatase, part of the DUF89 protein family; dephosphorylates fructose-1-phosphate; human ortholog, C6orf211 is involved in response to DNA damage; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR027W"}


id: YMR028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04235":null,"YMR028W":null},"has_protein_features":false,"name":"TAP42","ortholog_annotations":[{"gene_uniquename":"YMR028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04235","reference_uniquename":"PMID:29761456"}],"product":"Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR028W"}


id: YMR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02514":null,"YMR029C":null},"has_protein_features":false,"name":"FAR8","ortholog_annotations":[{"gene_uniquename":"YMR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02514","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR029C"}


id: YMR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RSF1","product":"Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes","secondary_identifier":"SGD:S000004632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR030W"}


id: YMR030W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; mCherry fusion protein localizes to the cytosol","secondary_identifier":"SGD:S000028574","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR030W-A"}


id: YMR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04227":null,"YMR031C":null},"has_protein_features":false,"name":"EIS1","ortholog_annotations":[{"gene_uniquename":"YMR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04227","reference_uniquename":"PMID:29761456"}],"product":"Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog, YKL050C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004633","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR031C"}


id: YMR031W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C","secondary_identifier":"SGD:S000004634","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR031W-A"}


id: YMR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03596":null,"SJAG_04077":null,"YMR032W":null},"has_protein_features":false,"name":"HOF1","ortholog_annotations":[{"gene_uniquename":"YMR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03596","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04077","reference_uniquename":"PMID:29761456"}],"product":"F-BAR protein that regulates actin cytoskeleton organization; binds and bundles actin filaments, linking them to septins; required for cytokinesis, actin cable organization, and secretory vesicle trafficking; regulates actomyosin ring dynamics and septin localization; N-term. half controls cell size and actin cable levels, while the C-term. half controls actin cable organization, inhibiting Bnr1p-mediated actin nucleation; forms axial striations/pillars at the bud neck; phosphorylated by Dbf2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004635","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR032W"}


id: YMR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02869":null,"YMR033W":null},"has_protein_features":false,"name":"ARP9","ortholog_annotations":[{"gene_uniquename":"YMR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02869","reference_uniquename":"PMID:29761456"}],"product":"Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004636","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR033W"}


id: YMR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RCH1","product":"Negative regulator of cytosolic calcium homeostasis; localizes to the plasma membrane, concentrating at the bud neck during cell division; regulated by Crz1p through a CDRE promoter element; non-essential gene; putative transporter with sequence similarity to human SLC10A7; functional homolog of C. albicans RCH1","secondary_identifier":"SGD:S000004637","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR034C"}


id: YMR035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02809":null,"YMR035W":null},"has_protein_features":false,"name":"IMP2","ortholog_annotations":[{"gene_uniquename":"YMR035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02809","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits (Imp1p and Imp2p that differ in substrate specificity), and Som1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR035W"}


id: YMR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04332":null,"YMR036C":null},"has_protein_features":false,"name":"MIH1","ortholog_annotations":[{"gene_uniquename":"YMR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04332","reference_uniquename":"PMID:29761456"}],"product":"Protein tyrosine phosphatase; involved in cell cycle control and retrograde protein transport; regulates the phosphorylation state of Cdc28p; modulates phosphorylation of retromer component Vps26p; homolog of S. pombe cdc25","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004639","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR036C"}


id: YMR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03388":null,"YMR037C":null},"has_protein_features":false,"name":"MSN2","ortholog_annotations":[{"gene_uniquename":"YMR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03388","reference_uniquename":"PMID:29761456"}],"product":"Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes; light sensing pathway component that accumulates in the nucleus in response to blue light; relative distribution to nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004640","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR037C"}


id: YMR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04403":null,"YMR038C":null},"has_protein_features":false,"name":"CCS1","ortholog_annotations":[{"gene_uniquename":"YMR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04403","reference_uniquename":"PMID:29761456"}],"product":"Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within N-terminus is involved in insertion of copper into Sod1p under conditions of copper deprivation; required for regulation of yeast copper genes in response to DNA-damaging agents; protein abundance increases in response to DNA replication stress; human homolog CCS can complement yeast ccs1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004641","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR038C"}


id: YMR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01771":null,"YMR039C":null},"has_protein_features":false,"name":"SUB1","ortholog_annotations":[{"gene_uniquename":"YMR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01771","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional regulator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in nonhomologous end-joining (NHEJ) of ds breaks in plasmid DNA, but not chromosomal DNA; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; negatively regulates sporulation; protein abundance increases in response to DNA replication stress; functionally complemented by human SUB1 (PC4)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR039C"}


id: YMR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03244":null,"YMR040W":null},"has_protein_features":false,"name":"YET2","ortholog_annotations":[{"gene_uniquename":"YMR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03244","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function that may interact with ribosomes; based on co-purification experiments; homolog of human BAP31 protein; YET2 has a paralog, YET1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR040W"}


id: YMR041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ARA2","product":"NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase","secondary_identifier":"SGD:S000004644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR041C"}


id: YMR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00210":null,"SJAG_02218":null,"YMR042W":null},"has_protein_features":false,"name":"ARG80","ortholog_annotations":[{"gene_uniquename":"YMR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00210","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02218","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor involved in regulating arginine-responsive genes; acts with Arg81p and Arg82p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR042W"}


id: YMR043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00210":null,"SJAG_02218":null,"YMR043W":null},"has_protein_features":false,"name":"MCM1","ortholog_annotations":[{"gene_uniquename":"YMR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00210","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02218","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor; involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR043W"}


id: YMR044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IOC4","product":"Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing","secondary_identifier":"SGD:S000004647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR044W"}


id: YMR046W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR046W-A"}


id: YMR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03299":null,"YMR047C":null},"has_protein_features":false,"name":"NUP116","ortholog_annotations":[{"gene_uniquename":"YMR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03299","reference_uniquename":"PMID:26896847"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p); NUP116 has a paralog, NUP100, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004650","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR047C"}


id: YMR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03097":null,"YMR048W":null},"has_protein_features":false,"name":"CSM3","ortholog_annotations":[{"gene_uniquename":"YMR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03097","reference_uniquename":"PMID:29761456"}],"product":"Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR048W"}


id: YMR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02830":null,"YMR049C":null},"has_protein_features":false,"name":"ERB1","ortholog_annotations":[{"gene_uniquename":"YMR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02830","reference_uniquename":"PMID:29761456"}],"product":"Constituent of 66S pre-ribosomal particles; forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; binds RNA via its C-terminal domain; homologous to mammalian Bop1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR049C"}


id: YMR052C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR052C-A"}


id: YMR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FAR3","product":"Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR052W"}


id: YMR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STB2","product":"Protein that interacts with Sin3p in a two-hybrid assay; part of a large protein complex with Sin3p and Stb1p; STB2 has a paralog, STB6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR053C"}


id: YMR054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00516":null,"YMR054W":null},"has_protein_features":false,"name":"STV1","ortholog_annotations":[{"gene_uniquename":"YMR054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00516","reference_uniquename":"PMID:29761456"}],"product":"Subunit a of the vacuolar-ATPase V0 domain; encodes one of two isoforms, located in both Golgi and endosomal V-ATPase complexes while VPH1 encodes the second isoform and is located in vacuolar V-ATPase complexes; interaction with PI(4)P is required for efficient localization and function of Stv1-containing V-ATPases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR054W"}


id: YMR055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01386":null,"YMR055C":null},"has_protein_features":false,"name":"BUB2","ortholog_annotations":[{"gene_uniquename":"YMR055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01386","reference_uniquename":"PMID:29761456"}],"product":"Mitotic exit network regulator; forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR055C"}


id: YMR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02050":null,"YMR056C":null},"has_protein_features":false,"name":"AAC1","ortholog_annotations":[{"gene_uniquename":"YMR056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02050","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR056C"}


id: YMR057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1","secondary_identifier":"SGD:S000004661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR057C"}


id: YMR058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04677":null,"YMR058W":null},"has_protein_features":false,"name":"FET3","ortholog_annotations":[{"gene_uniquename":"YMR058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04677","reference_uniquename":"PMID:29761456"}],"product":"Ferro-O2-oxidoreductase; multicopper oxidase that oxidizes ferrous (Fe2+) to ferric iron (Fe3+) for subsequent cellular uptake by transmembrane permease Ftr1p; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR058W"}


id: YMR059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04907":null,"YMR059W":null},"has_protein_features":false,"name":"SEN15","ortholog_annotations":[{"gene_uniquename":"YMR059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04907","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004663","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR059W"}


id: YMR060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02355":null,"YMR060C":null},"has_protein_features":false,"name":"SAM37","ortholog_annotations":[{"gene_uniquename":"YMR060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02355","reference_uniquename":"PMID:29761456"}],"product":"Component of the Sorting and Assembly Machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004664","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR060C"}


id: YMR061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03594":null,"YMR061W":null},"has_protein_features":false,"name":"RNA14","ortholog_annotations":[{"gene_uniquename":"YMR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03594","reference_uniquename":"PMID:29761456"}],"product":"Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004665","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR061W"}


id: YMR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01592":null,"YMR062C":null},"has_protein_features":false,"name":"ARG7","ortholog_annotations":[{"gene_uniquename":"YMR062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01592","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ornithine acetyltransferase; catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004666","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR062C"}


id: YMR063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01189":null,"SJAG_04058":null,"YMR063W":null},"has_protein_features":false,"name":"RIM9","ortholog_annotations":[{"gene_uniquename":"YMR063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01189","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04058","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004667","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR063W"}


id: YMR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AEP1","product":"Protein required for expression of the mitochondrial OLI1 gene; mitochondrial OLI1 gene encodes subunit 9 of F1-F0 ATP synthase","secondary_identifier":"SGD:S000004668","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR064W"}


id: YMR065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00810":null,"YMR065W":null},"has_protein_features":false,"name":"KAR5","ortholog_annotations":[{"gene_uniquename":"YMR065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00810","reference_uniquename":"PMID:29761456"}],"product":"Protein required for nuclear membrane fusion during karyogamy; localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; similar to zebrafish Brambleberry protein; expression of the gene is regulated by pheromone","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR065W"}


id: YMR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SOV1","product":"Mitochondrial protein of unknown function","secondary_identifier":"SGD:S000004670","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR066W"}


id: YMR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00490":null,"YMR067C":null},"has_protein_features":false,"name":"UBX4","ortholog_annotations":[{"gene_uniquename":"YMR067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00490","reference_uniquename":"PMID:29761456"}],"product":"UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the role of the Cdc48p-Nplp-Ufd1p AAA ATPase complex in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress; human ortholog ASPSCR1 partially complements the yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR067C"}


id: YMR068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AVO2","product":"Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth","secondary_identifier":"SGD:S000004672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR068W"}


id: YMR069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03537":null,"YMR069W":null},"has_protein_features":false,"name":"NAT4","ortholog_annotations":[{"gene_uniquename":"YMR069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03537","reference_uniquename":"PMID:29761456"}],"product":"N alpha-acetyl-transferase; involved in acetylation of the N-terminal residues of histones H4 and H2A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR069W"}


id: YMR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MOT3","product":"Transcriptional repressor, activator; role in cellular adjustment to osmotic stress including modulation of mating efficiency; involved in repression of subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of Tup1p-Cyc8p general repressor to promoters; relocalizes to cytosol under hypoxia; forms [MOT3+] prion under anaerobic conditions","secondary_identifier":"SGD:S000004674","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR070W"}


id: YMR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01206":null,"YMR071C":null},"has_protein_features":false,"name":"TVP18","ortholog_annotations":[{"gene_uniquename":"YMR071C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01206","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments; may have a role in intracellular sterol transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004675","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR071C"}


id: YMR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ABF2","product":"Mitochondrial DNA-binding protein; involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation; ABF2 has a paralog, IXR1, that arose from the whole genome duplication; human homolog TFAM can complement yeast abf2 mutant, rescuing the loss-of-mitochondrial DNA phenotype","secondary_identifier":"SGD:S000004676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR072W"}


id: YMR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02794":null,"YMR073C":null},"has_protein_features":false,"name":"IRC21","ortholog_annotations":[{"gene_uniquename":"YMR073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02794","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR073C"}


id: YMR074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02367":null,"YMR074C":null},"has_protein_features":false,"name":"SDD2","ortholog_annotations":[{"gene_uniquename":"YMR074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02367","reference_uniquename":"PMID:29761456"}],"product":"Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR074C"}


id: YMR075C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; almost completely overlaps verified ORF RCO1/YMR075W","secondary_identifier":"SGD:S000004679","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR075C-A"}


id: YMR075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01110":null,"SJAG_03884":null,"YMR075W":null},"has_protein_features":false,"name":"RCO1","ortholog_annotations":[{"gene_uniquename":"YMR075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01110","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03884","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the Rpd3S histone deacetylase complex; interacts with Eaf3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004680","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR075W"}


id: YMR076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04508":null,"YMR076C":null},"has_protein_features":false,"name":"PDS5","ortholog_annotations":[{"gene_uniquename":"YMR076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04508","reference_uniquename":"PMID:29761456"}],"product":"Cohesion maintenance factor; involved in sister chromatid condensation and cohesion; colocalizes with cohesin on chromosomes; performs its cohesin maintenance function in pre-anaphase cells by protecting the integrity of the cohesion complex; also required during meiosis; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004681","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR076C"}


id: YMR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00416":null,"YMR077C":null},"has_protein_features":false,"name":"VPS20","ortholog_annotations":[{"gene_uniquename":"YMR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00416","reference_uniquename":"PMID:29761456"}],"product":"Myristoylated subunit of the ESCRT-III complex; the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004682","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR077C"}


id: YMR078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02610":null,"YMR078C":null},"has_protein_features":false,"name":"CTF18","ortholog_annotations":[{"gene_uniquename":"YMR078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02610","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a complex with Ctf8p; shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004683","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR078C"}


id: YMR079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03746":null,"YMR079W":null},"has_protein_features":false,"name":"SEC14","ortholog_annotations":[{"gene_uniquename":"YMR079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03746","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs; SEC14 has a paralog, YKL091C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR079W"}


id: YMR080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03886":null,"YMR080C":null},"has_protein_features":false,"name":"NAM7","ortholog_annotations":[{"gene_uniquename":"YMR080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03886","reference_uniquename":"PMID:29761456"}],"product":"ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; binds to the small ribosomal subunit via an interaction with Rps26; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004685","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR080C"}


id: YMR081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ISF1","product":"Serine-rich, hydrophilic protein; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant; ISF1 has a paralog, MBR1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004686","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR081C"}


id: YMR082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YMR082C is not an essential gene","secondary_identifier":"SGD:S000004687","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR082C"}


id: YMR083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01414":null,"SJAG_03370":null,"YMR083W":null},"has_protein_features":false,"name":"ADH3","ortholog_annotations":[{"gene_uniquename":"YMR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01414","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03370","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004688","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR083W"}


id: YMR084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04728":null,"YMR084W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YMR084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04728","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004689","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR084W"}


id: YMR085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1","secondary_identifier":"SGD:S000004690","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR085W"}


id: YMR086C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004691","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR086C-A"}


id: YMR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02087":null,"YMR086W":null},"has_protein_features":false,"name":"SEG1","ortholog_annotations":[{"gene_uniquename":"YMR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02087","reference_uniquename":"PMID:29761456"}],"product":"Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation, controls eisosome length and shape; diffusely distributed, forms heterogeneous patches at plasma membrane in small buds, also found in medium and large buds; expression repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes; SEG1 has a paralog, SEG2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004692","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR086W"}


id: YMR087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PDL32","product":"Putative ADP-ribose-1''-monophosphatase; converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain","secondary_identifier":"SGD:S000004693","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR087W"}


id: YMR088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02029":null,"SJAG_04725":null,"YMR088C":null},"has_protein_features":false,"name":"VBA1","ortholog_annotations":[{"gene_uniquename":"YMR088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02029","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04725","reference_uniquename":"PMID:29761456"}],"product":"Permease of basic amino acids in the vacuolar membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004694","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR088C"}


id: YMR089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01179":null,"YMR089C":null},"has_protein_features":false,"name":"YTA12","ortholog_annotations":[{"gene_uniquename":"YMR089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01179","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; overexpression of human AFG3L2 complements respiratory defect of yeast afg3 yta12 double null mutation, but overexpression of disease-associated AFG3L2 variants does not; expression of both human SPG7 (paraplegin) and AFG3L2 complements yeast yta12 afg3 double mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004695","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR089C"}


id: YMR090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00366":null,"YMR090W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YMR090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00366","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; similar to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004696","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR090W"}


id: YMR091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03944":null,"YMR091C":null},"has_protein_features":false,"name":"NPL6","ortholog_annotations":[{"gene_uniquename":"YMR091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03944","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004697","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR091C"}


id: YMR092C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03380":null,"YMR092C":null},"has_protein_features":false,"name":"AIP1","ortholog_annotations":[{"gene_uniquename":"YMR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03380","reference_uniquename":"PMID:29761456"}],"product":"Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; inhibits elongation of aged ADP-actin filaments decorated with cofilin to maintain a high level of assembly-competent actin species; required to restrict cofilin localization to cortical patches; putative regulator of cytokinesis; contains WD repeats; mutations in human homolog WDR1 are associated with cardiac hypertrophy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004698","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR092C"}


id: YMR093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02608":null,"YMR093W":null},"has_protein_features":false,"name":"UTP15","ortholog_annotations":[{"gene_uniquename":"YMR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02608","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004699","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR093W"}


id: YMR094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CTF13","product":"Subunit of the CBF3 complex; F-box protein of the leucine-rich-repeat family; required for assembly of the complex; CBF3 binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis","secondary_identifier":"SGD:S000004700","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR094W"}


id: YMR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00691":null,"YMR095C":null},"has_protein_features":false,"name":"SNO1","ortholog_annotations":[{"gene_uniquename":"YMR095C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00691","reference_uniquename":"PMID:29761456"}],"product":"Protein of unconfirmed function; involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004701","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR095C"}


id: YMR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00283":null,"YMR096W":null},"has_protein_features":false,"name":"SNZ1","ortholog_annotations":[{"gene_uniquename":"YMR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00283","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a two-component pyridoxal-5'-phosphate synthase; involved in pyridoxine (vitamin B6) biosynthesis from glyceraldehyde-3-phosphate, ribose-5-phosphate and ammonia liberated from glutamine by glutaminase; forms a complex with Sno1p that functions as an active glutaminase; member of a stationary phase-induced gene family where transcriptional induction occurs during the postdiauxic phase; co-regulated with SNO1; paralog of SNZ2 and SNZ3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004702","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR096W"}


id: YMR097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00659":null,"YMR097C":null},"has_protein_features":false,"name":"MTG1","ortholog_annotations":[{"gene_uniquename":"YMR097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00659","reference_uniquename":"PMID:29761456"}],"product":"Putative GTPase peripheral to the mitochondrial inner membrane; essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004703","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR097C"}


id: YMR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00797":null,"YMR098C":null},"has_protein_features":false,"name":"ATP25","ortholog_annotations":[{"gene_uniquename":"YMR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00797","reference_uniquename":"PMID:29761456"}],"product":"Protein that associates with mitochondrial ribosome; required for the stability of Oli1p (Atp9p) mRNA; also required for the Oli1p ring formation; YMR098C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR098C"}


id: YMR099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase); likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000004705","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR099C"}


id: YMR100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00910":null,"YMR100W":null},"has_protein_features":false,"name":"MUB1","ortholog_annotations":[{"gene_uniquename":"YMR100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00910","reference_uniquename":"PMID:29761456"}],"product":"MYND domain-containing protein; component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex, required for ubiquitination and degradation of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; proposed to function as both a partner and substrate of the Ubr2p/Rad6p ubiquitin ligase; similar to the A. nidulans samB gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004706","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR100W"}


id: YMR101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02163":null,"YMR101C":null},"has_protein_features":false,"name":"SRT1","ortholog_annotations":[{"gene_uniquename":"YMR101C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02163","reference_uniquename":"PMID:29761456"}],"product":"Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1; involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004707","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR101C"}


id: YMR102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01563":null,"SJAG_03432":null,"YMR102C":null},"has_protein_features":false,"name":"LAF1","ortholog_annotations":[{"gene_uniquename":"YMR102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01563","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03432","reference_uniquename":"PMID:29761456"}],"product":"Sterol-binding beta-propeller protein; physically associates with sterol-binding StARkin domain-containing proteins Ysp2/Lam2/Ltc4 and Lam4/Ltc3; essential for retrograde transport of ergosterol from the plasma membrane to the endoplasmic reticulum at ER-PM contact sites; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; non-essential gene; has a paralog, DGR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004708","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR102C"}


id: YMR103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YMR103C is not an essential gene","secondary_identifier":"SGD:S000004709","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR103C"}


id: YMR104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04206":null,"YMR104C":null},"has_protein_features":false,"name":"YPK2","ortholog_annotations":[{"gene_uniquename":"YMR104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04206","reference_uniquename":"PMID:29761456"}],"product":"AGC-type S/T protein kinase; participates in the cell wall integrity signaling pathway; involved with Ypk1p in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6), and in the direct phosphorylation of the Myo5p motor domain TEDS site; phosphorylated and activated by Pkh1/2p in the presence of phytosphingosine; direct phosphorylation by Tor2p regulates actin polarization; genetically redundant with YPK1; human homolog SGK2 can complement the inviability of a ypk1 ypk2 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004710","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR104C"}


id: YMR105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01209":null,"YMR105C":null},"has_protein_features":false,"name":"PGM2","ortholog_annotations":[{"gene_uniquename":"YMR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01209","reference_uniquename":"PMID:29761456"}],"product":"Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress; PGM2 has a paralog, PGM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004711","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR105C"}


id: YMR105W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028692","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR105W-A"}


id: YMR106C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04372":null,"YMR106C":null},"has_protein_features":false,"name":"YKU80","ortholog_annotations":[{"gene_uniquename":"YMR106C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04372","reference_uniquename":"PMID:29761456"}],"product":"Subunit of telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein via interaction with TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair; colocalizes with quiescent cell telomere hyperclusters","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004712","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR106C"}


id: YMR107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPG4","product":"Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources","secondary_identifier":"SGD:S000004713","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR107W"}


id: YMR108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03985":null,"YMR108W":null},"has_protein_features":false,"name":"ILV2","ortholog_annotations":[{"gene_uniquename":"YMR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03985","reference_uniquename":"PMID:29761456"}],"product":"Acetolactate synthase; catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004714","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR108W"}


id: YMR109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04001":null,"YMR109W":null},"has_protein_features":false,"name":"MYO5","ortholog_annotations":[{"gene_uniquename":"YMR109W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04001","reference_uniquename":"PMID:29761456"}],"product":"One of two type I myosin motors; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO5 has a paralog, MYO3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004715","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR109W"}


id: YMR110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HFD1","product":"Dehydrogenase involved in ubiquinone and sphingolipid metabolism; converts 4-hydroxybenzaldehyde into 4-hydroxybenzoate for ubiquinone anabolism, hexadecenal to hexadecenoic acid in sphingosine 1-phosphate catabolism; human homolog ALDH3A2, mutated in Sjogren-Larsson syndrome, can rescue yeast hfd1 mutant; human ALDH3A1, but not ALDH3A2, rescues pABA- respiratory growth phenotype of hfd1 null; data suggest that dual functions of Hfd1p have diverged in human ALDH3A1, ALDH3A2","secondary_identifier":"SGD:S000004716","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR110C"}


id: YMR111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EUC1","product":"Sequence-specific DNA binding protein; binds to a sequence motif associated with distinct genomic hotspots of non-H2B protein ubiquitylation (ub-hotspots); interacts with Slx5p to recruit the Slx5-Slx8  SUMO-targeted Ub ligase (STUbL) complex to ub-hotspots; deletion prevents ub-hotspot formation and exacerbates heat sensitivity of cells deficient in Rpd3L histone deacetylase complex members; forms nuclear foci upon DNA replication stress","secondary_identifier":"SGD:S000004717","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR111C"}


id: YMR112C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01403":null,"YMR112C":null},"has_protein_features":false,"name":"MED11","ortholog_annotations":[{"gene_uniquename":"YMR112C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01403","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004718","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR112C"}


id: YMR113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00529":null,"YMR113W":null},"has_protein_features":false,"name":"FOL3","ortholog_annotations":[{"gene_uniquename":"YMR113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00529","reference_uniquename":"PMID:29761456"}],"product":"Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis; FOL3 has a paralog, RMA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004719","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR113W"}


id: YMR114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene","secondary_identifier":"SGD:S000004720","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR114C"}


id: YMR115W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00354":null,"YMR115W":null},"has_protein_features":false,"name":"MGR3","ortholog_annotations":[{"gene_uniquename":"YMR115W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00354","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004721","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR115W"}


id: YMR116C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05000":null,"YMR116C":null},"has_protein_features":false,"name":"ASC1","ortholog_annotations":[{"gene_uniquename":"YMR116C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05000","reference_uniquename":"PMID:29761456"}],"product":"G-protein beta subunit and guanine dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; required to prevent frameshifting at ribosomes stalled at repeated CGA codons; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation; controls phosphorylation of multiple proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004722","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR116C"}


id: YMR117C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02814":null,"YMR117C":null},"has_protein_features":false,"name":"SPC24","ortholog_annotations":[{"gene_uniquename":"YMR117C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02814","reference_uniquename":"PMID:29761456"}],"product":"Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004723","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR117C"}


id: YMR118C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03920":null,"YMR118C":null},"has_protein_features":false,"name":"SHH3","ortholog_annotations":[{"gene_uniquename":"YMR118C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03920","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial inner membrane protein of unknown function; although similar to paralogous Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase; SHH3 has a paralog, SDH3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR118C"}


id: YMR119W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ASI1","product":"Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; the Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and regulators of sterol biosynthesis for ubiquitin-mediated degradation; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids","secondary_identifier":"SGD:S000004725","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR119W"}


id: YMR119W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of ORF ASI1/YMR119W","secondary_identifier":"SGD:S000004726","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR119W-A"}


id: YMR120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04681":null,"YMR120C":null},"has_protein_features":false,"name":"ADE17","ortholog_annotations":[{"gene_uniquename":"YMR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04681","reference_uniquename":"PMID:29761456"}],"product":"Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004727","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR120C"}


id: YMR121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03919":null,"SJAG_04478":null,"YMR121C":null},"has_protein_features":false,"name":"RPL15B","ortholog_annotations":[{"gene_uniquename":"YMR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03919","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04478","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004728","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR121C"}


id: YMR122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YMR122C is not an essential gene","secondary_identifier":"SGD:S000004729","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR122C"}


id: YMR122W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NCW1","product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum","secondary_identifier":"SGD:S000007524","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR122W-A"}


id: YMR123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05306":null,"YMR123W":null},"has_protein_features":false,"name":"PKR1","ortholog_annotations":[{"gene_uniquename":"YMR123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05306","reference_uniquename":"PMID:29761456"}],"product":"V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004730","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR123W"}


id: YMR124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EPO1","product":"Protein involved in septin-ER tethering; interacts with ER membrane protein, Scs2p, and Shs1p, a septin ring component, at bud neck to create ER diffusion barrier; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W has a paralog, YLR031W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004731","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR124W"}


id: YMR125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04360":null,"YMR125W":null},"has_protein_features":false,"name":"STO1","ortholog_annotations":[{"gene_uniquename":"YMR125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04360","reference_uniquename":"PMID:29761456"}],"product":"Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004732","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR125W"}


id: YMR126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DLT1","product":"Protein of unknown function; mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)","secondary_identifier":"SGD:S000004733","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR126C"}


id: YMR127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SAS2","product":"Histone acetyltransferase (HAT) catalytic subunit of the SAS complex; acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family; other members are Sas4p and Sas5p","secondary_identifier":"SGD:S000004734","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR127C"}


id: YMR128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03077":null,"YMR128W":null},"has_protein_features":false,"name":"ECM16","ortholog_annotations":[{"gene_uniquename":"YMR128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03077","reference_uniquename":"PMID:29761456"}],"product":"Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; functions with methyltransferase Bud23p; predominantly nucleolar in distribution; required for 18S rRNA synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004735","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR128W"}


id: YMR129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01834":null,"YMR129W":null},"has_protein_features":false,"name":"POM152","ortholog_annotations":[{"gene_uniquename":"YMR129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01834","reference_uniquename":"PMID:29761456"}],"product":"Glycoprotein subunit of transmembrane ring of nuclear pore complex; contributes to nucleocytoplasmic transport, nuclear pore complex (NPC) biogenesis and spindle pole body duplication; type II transmembrane protein composed of N-terminal cytosolic and C-terminal nuclear envelope lumenal domains; homologous to human NUP210","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004736","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR129W"}


id: YMR130W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04501":null,"YMR130W":null},"has_protein_features":false,"name":"DPI35","ortholog_annotations":[{"gene_uniquename":"YMR130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04501","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial protein of unknown function; DPI35 is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004737","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR130W"}


id: YMR131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01122":null,"YMR131C":null},"has_protein_features":false,"name":"RRB1","ortholog_annotations":[{"gene_uniquename":"YMR131C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01122","reference_uniquename":"PMID:29761456"}],"product":"Specific assembly chaperone for ribosomal protein Rpl3p; co-translationally associates with nascent Rpl3p, preventing aggregation, and facilitating nuclear import; required for biogenesis of preribosomal particles; essential gene; contains five WD-repeat motifs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004738","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR131C"}


id: YMR132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01390":null,"YMR132C":null},"has_protein_features":false,"name":"JLP2","ortholog_annotations":[{"gene_uniquename":"YMR132C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01390","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function; contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004739","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR132C"}


id: YMR133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07002":null,"YMR133W":null},"has_protein_features":false,"name":"REC114","ortholog_annotations":[{"gene_uniquename":"YMR133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07002","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004740","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR133W"}


id: YMR134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ERG29","product":"Protein of unknown function involved in ergosterol biosynthesis; conditional mutants produce less ergosterol, display impaired oxygen consumption, respiratory growth, mitochondrial iron utilization, and are more sensitive to oxidative stress; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; protein localizes to the cytoplasm, ER and nuclear envelope; highly conserved in ascomycetes","secondary_identifier":"SGD:S000004741","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR134W"}


id: YMR135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01886":null,"YMR135C":null},"has_protein_features":false,"name":"GID8","ortholog_annotations":[{"gene_uniquename":"YMR135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01886","reference_uniquename":"PMID:29761456"}],"product":"Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004742","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR135C"}


id: YMR135W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004743","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR135W-A"}


id: YMR136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GAT2","product":"Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine","secondary_identifier":"SGD:S000004744","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR136W"}


id: YMR137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03734":null,"YMR137C":null},"has_protein_features":false,"name":"PSO2","ortholog_annotations":[{"gene_uniquename":"YMR137C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03734","reference_uniquename":"PMID:29761456"}],"product":"Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004745","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR137C"}


id: YMR138W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00983":null,"YMR138W":null},"has_protein_features":false,"name":"CIN4","ortholog_annotations":[{"gene_uniquename":"YMR138W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00983","reference_uniquename":"PMID:29761456"}],"product":"GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004746","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR138W"}


id: YMR139W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00718":null,"SJAG_05304":null,"YMR139W":null},"has_protein_features":false,"name":"RIM11","ortholog_annotations":[{"gene_uniquename":"YMR139W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00718","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR139W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05304","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004747","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR139W"}


id: YMR140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02603":null,"YMR140W":null},"has_protein_features":false,"name":"SIP5","ortholog_annotations":[{"gene_uniquename":"YMR140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02603","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004748","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR140W"}


id: YMR141C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YMR141C is not an essential gene","secondary_identifier":"SGD:S000004749","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR141C"}


id: YMR141W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene RPL13B/YMR142C","secondary_identifier":"SGD:S000028575","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR141W-A"}


id: YMR142C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01608":null,"SJAG_03423":null,"YMR142C":null},"has_protein_features":false,"name":"RPL13B","ortholog_annotations":[{"gene_uniquename":"YMR142C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR142C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03423","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004750","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR142C"}


id: YMR143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01609":null,"SJAG_03422":null,"YMR143W":null},"has_protein_features":false,"name":"RPS16A","ortholog_annotations":[{"gene_uniquename":"YMR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01609","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03422","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004751","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR143W"}


id: YMR144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FDO1","product":"Protein involved in directionality of mating type switching; acts with Fkh1p to control which donor mating-type locus is inserted into MAT locus during mating type switching; localized to the nucleus; not an essential gene","secondary_identifier":"SGD:S000004752","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR144W"}


id: YMR145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01539":null,"YMR145C":null},"has_protein_features":false,"name":"NDE1","ortholog_annotations":[{"gene_uniquename":"YMR145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01539","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial external NADH dehydrogenase; type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain; NDE1 has a paralog, NDE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004753","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR145C"}


id: YMR146C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02164":null,"YMR146C":null},"has_protein_features":false,"name":"TIF34","ortholog_annotations":[{"gene_uniquename":"YMR146C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02164","reference_uniquename":"PMID:29761456"}],"product":"eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; stimulates rate of ribosomal scanning during translation reinitiation; eIF3 is also involved in programmed stop codon readthrough","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004754","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR146C"}


id: YMR147W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LDO45","product":"Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery","secondary_identifier":"SGD:S000004755","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR147W"}


id: YMR148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LDO16","product":"Protein of unknown function with possible role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion","secondary_identifier":"SGD:S000004756","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR148W"}


id: YMR149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04090":null,"YMR149W":null},"has_protein_features":false,"name":"SWP1","ortholog_annotations":[{"gene_uniquename":"YMR149W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04090","reference_uniquename":"PMID:29761456"}],"product":"Delta subunit of the oligosaccharyl transferase glycoprotein complex; complex is required for N-linked glycosylation of proteins in the endoplasmic reticulum","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004757","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR149W"}


id: YMR150C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03648":null,"YMR150C":null},"has_protein_features":false,"name":"IMP1","ortholog_annotations":[{"gene_uniquename":"YMR150C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03648","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits (Imp1p and Imp2p that differ in substrate specificty) and Som1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004758","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR150C"}


id: YMR151W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YIM2","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1","secondary_identifier":"SGD:S000004759","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR151W"}


id: YMR152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04376":null,"YMR152W":null},"has_protein_features":false,"name":"YIM1","ortholog_annotations":[{"gene_uniquename":"YMR152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04376","reference_uniquename":"PMID:29761456"}],"product":"Aldehyde reductase; involved in detoxification of lignocellulose-derived aldehydes; catalyzes the reduction of furan, aliphatic and aromatic aldehydes using either NADH or NADPH as co-factor; membrane of the quinone oxidoreductase subfamily of the medium-chain dehydrogenase/reductase family; null mutant displays sensitivity to DNA damaging agents; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004760","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR152W"}


id: YMR153C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps 3' end of verified gene NUP53/YMR153W","secondary_identifier":"SGD:S000004761","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR153C-A"}


id: YMR153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03593":null,"YMR153W":null},"has_protein_features":false,"name":"NUP53","ortholog_annotations":[{"gene_uniquename":"YMR153W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03593","reference_uniquename":"PMID:29761456"}],"product":"FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004762","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR153W"}


id: YMR154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RIM13","product":"Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB","secondary_identifier":"SGD:S000004763","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR154C"}


id: YMR155W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen","secondary_identifier":"SGD:S000004764","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR155W"}


id: YMR156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02680":null,"YMR156C":null},"has_protein_features":false,"name":"TPP1","ortholog_annotations":[{"gene_uniquename":"YMR156C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02680","reference_uniquename":"PMID:29761456"}],"product":"DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3'-phosphatase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004765","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR156C"}


id: YMR157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM36","product":"Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000004766","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR157C"}


id: YMR158C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; may contain a lipid attachment site; YMR158C-A is not an essential gene","secondary_identifier":"SGD:S000007249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR158C-A"}


id: YMR158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05320":null,"YMR158W":null},"has_protein_features":false,"name":"MRPS8","ortholog_annotations":[{"gene_uniquename":"YMR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05320","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004767","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR158W"}


id: YMR158W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C","secondary_identifier":"SGD:S000004768","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR158W-B"}


id: YMR159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03136":null,"YMR159C":null},"has_protein_features":false,"name":"ATG16","ortholog_annotations":[{"gene_uniquename":"YMR159C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03136","reference_uniquename":"PMID:29761456"}],"product":"Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which binds to membranes and localizes to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004769","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR159C"}


id: YMR160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress","secondary_identifier":"SGD:S000004770","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR160W"}


id: YMR161W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01160":null,"YMR161W":null},"has_protein_features":false,"name":"HLJ1","ortholog_annotations":[{"gene_uniquename":"YMR161W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01160","reference_uniquename":"PMID:26896847"}],"product":"Co-chaperone for Hsp40p; anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004771","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR161W"}


id: YMR162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00669":null,"YMR162C":null},"has_protein_features":false,"name":"DNF3","ortholog_annotations":[{"gene_uniquename":"YMR162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00669","reference_uniquename":"PMID:29761456"}],"product":"Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004772","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR162C"}


id: YMR163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04315":null,"YMR163C":null},"has_protein_features":false,"name":"INP2","ortholog_annotations":[{"gene_uniquename":"YMR163C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04315","reference_uniquename":"PMID:29761456"}],"product":"Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004773","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR163C"}


id: YMR164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MSS11","product":"Transcription factor; involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals; forms a heterodimer with Flo8p that interacts with the Swi/Snf complex during transcriptional activation of FLO1, FLO11, and STA1","secondary_identifier":"SGD:S000004774","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR164C"}


id: YMR165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02763":null,"YMR165C":null},"has_protein_features":false,"name":"PAH1","ortholog_annotations":[{"gene_uniquename":"YMR165C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02763","reference_uniquename":"PMID:29761456"}],"product":"Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; regulates phospholipid synthesis, nuclear/ER membrane growth, lipid droplet formation, triacylglycerol synthesis, vacuolar homeostasis and cell wall integrity; phosphorylated by Pho85p/Pho80p, Cdc28p/Cyclin B, PKA, PKC, and CKII, regulating activity, localization, and proteosomal degradation; homolog of mammalian lipins 1 and 2; human homologs LPIN1, LPIN2, LPIN3 complement the null","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004775","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR165C"}


id: YMR166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02484":null,"YMR166C":null},"has_protein_features":false,"name":"MME1","ortholog_annotations":[{"gene_uniquename":"YMR166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02484","reference_uniquename":"PMID:29761456"}],"product":"Transporter of the mitochondrial inner membrane that exports magnesium; involved in mitochondrial Mg2+ homeostasis; has similarity to human mitochondrial ATP-Mg/Pi carriers","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004776","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR166C"}


id: YMR167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01620":null,"YMR167W":null},"has_protein_features":false,"name":"MLH1","ortholog_annotations":[{"gene_uniquename":"YMR167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01620","reference_uniquename":"PMID:29761456"}],"product":"Protein required for mismatch repair in mitosis and meiosis; also required for crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; required for silencing at the silent mating-type loci and telomeres; human homolog is associated with hereditary non-polyposis colon cancer","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004777","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR167W"}


id: YMR168C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CEP3","product":"Essential kinetochore protein; component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain","secondary_identifier":"SGD:S000004778","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR168C"}


id: YMR169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ALD3","product":"Cytoplasmic aldehyde dehydrogenase; involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose","secondary_identifier":"SGD:S000004779","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR169C"}


id: YMR170C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ALD2","product":"Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p","secondary_identifier":"SGD:S000004780","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR170C"}


id: YMR171C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01586":null,"YMR171C":null},"has_protein_features":false,"name":"EAR1","ortholog_annotations":[{"gene_uniquename":"YMR171C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01586","reference_uniquename":"PMID:29761456"}],"product":"Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004781","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR171C"}


id: YMR172C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps 3' end of ORF HOT1/YMR172W","secondary_identifier":"SGD:S000004782","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR172C-A"}


id: YMR172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HOT1","product":"Transcription factor for glycerol biosynthetic genes; required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p","secondary_identifier":"SGD:S000004783","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR172W"}


id: YMR173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02442":null,"YMR173W":null},"has_protein_features":false,"name":"DDR48","ortholog_annotations":[{"gene_uniquename":"YMR173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02442","reference_uniquename":"PMID:29761456"}],"product":"DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR173W"}


id: YMR173W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W","secondary_identifier":"SGD:S000004785","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR173W-A"}


id: YMR174C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAI3","product":"Cytoplasmic proteinase A (Pep4p) inhibitor; dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact","secondary_identifier":"SGD:S000004786","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR174C"}


id: YMR175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SIP18","product":"Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress; SIP18 has a paralog, GRE1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004787","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR175W"}


id: YMR175W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028848","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR175W-A"}


id: YMR176W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01465":null,"SJAG_03635":null,"YMR176W":null},"has_protein_features":false,"name":"ECM5","ortholog_annotations":[{"gene_uniquename":"YMR176W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01465","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YMR176W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03635","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Snt2C complex; physically associates with Snt2p and Rpd3p; along with Snt2p, recruits Rpd3p to a small number of promoters; also colocalizes with Snt2p, independently of Rpd3p, to promoters of stress response genes in response to oxidative stress; contains ATP/GTP-binding site motif A; null mutant exhibits increased cellular volume, large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004788","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR176W"}


id: YMR177W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04260":null,"YMR177W":null},"has_protein_features":false,"name":"MMT1","ortholog_annotations":[{"gene_uniquename":"YMR177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04260","reference_uniquename":"PMID:29761456"}],"product":"Putative metal transporter involved in mitochondrial iron accumulation; MMT1 has a paralog, MMT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004789","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR177W"}


id: YMR178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FPY1","product":"FAD pyrophosphatase; hydrolyzes FAD as the preferred substrate but also acts on NADH and ADP-ribose at lower rates; activity is dependent upon K+ and divalent metal cations; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; FPY1 is not an essential gene; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004790","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR178W"}


id: YMR179W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03183":null,"YMR179W":null},"has_protein_features":false,"name":"SPT21","ortholog_annotations":[{"gene_uniquename":"YMR179W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03183","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; binds with Spt10p to histone gene promoters during S phase; localizes to nuclear foci that become diffuse upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004791","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR179W"}


id: YMR180C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04488":null,"YMR180C":null},"has_protein_features":false,"name":"CTL1","ortholog_annotations":[{"gene_uniquename":"YMR180C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04488","reference_uniquename":"PMID:29761456"}],"product":"RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm; CTL1 has a paralog, CET1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004792","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR180C"}


id: YMR181C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004793","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR181C"}


id: YMR182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RGM1","product":"Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y' telomeric elements and subtelomeric COS genes; relocalizes to the cytosol in response to hypoxia; RGM1 has a paralog, USV1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004794","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR182C"}


id: YMR182W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIN3","product":"Mitochondrial protein of unknown function","secondary_identifier":"SGD:S000028693","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR182W-A"}


id: YMR183C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03536":null,"YMR183C":null},"has_protein_features":false,"name":"SSO2","ortholog_annotations":[{"gene_uniquename":"YMR183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03536","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p; SSO2 has a paralog, SSO1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004795","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR183C"}


id: YMR184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ADD37","product":"Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004796","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR184W"}


id: YMR185W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01328":null,"YMR185W":null},"has_protein_features":false,"name":"RTP1","ortholog_annotations":[{"gene_uniquename":"YMR185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01328","reference_uniquename":"PMID:29761456"}],"product":"Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004797","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR185W"}


id: YMR186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01664":null,"YMR186W":null},"has_protein_features":false,"name":"HSC82","ortholog_annotations":[{"gene_uniquename":"YMR186W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01664","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic chaperone of the Hsp90 family; plays a role in determining prion variants; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004798","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR186W"}


id: YMR187C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01212":null,"YMR187C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YMR187C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01212","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; YMR187C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004799","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR187C"}


id: YMR188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02359":null,"YMR188C":null},"has_protein_features":false,"name":"MRPS17","ortholog_annotations":[{"gene_uniquename":"YMR188C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02359","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004800","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR188C"}


id: YMR189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03861":null,"YMR189W":null},"has_protein_features":false,"name":"GCV2","ortholog_annotations":[{"gene_uniquename":"YMR189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03861","reference_uniquename":"PMID:29761456"}],"product":"P subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004801","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR189W"}


id: YMR190C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03898":null,"YMR190C":null},"has_protein_features":false,"name":"SGS1","ortholog_annotations":[{"gene_uniquename":"YMR190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03898","reference_uniquename":"PMID:29761456"}],"product":"RecQ family nucleolar DNA helicase; role in genome integrity maintenance, chromosome synapsis, meiotic joint molecule/crossover formation; stimulates activity of Top3p; rapidly lost in response to rapamycin in Rrd1p-dependent manner; forms nuclear foci upon DNA replication stress; yeast SGS1 complements mutations in human homolog BLM implicated in Bloom syndrome; also similar to human WRN implicated in Werner syndrome; human BLM and WRN can each complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004802","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR190C"}


id: YMR191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPG5","product":"Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources","secondary_identifier":"SGD:S000004803","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR191W"}


id: YMR192W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00092":null,"SJAG_02012":null,"YMR192W":null},"has_protein_features":false,"name":"GYL1","ortholog_annotations":[{"gene_uniquename":"YMR192W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00092","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR192W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02012","reference_uniquename":"PMID:29761456"}],"product":"Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress; GYL1 has a paralog, GYP5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004804","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR192W"}


id: YMR193C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004805","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR193C-A"}


id: YMR193W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02071":null,"YMR193W":null},"has_protein_features":false,"name":"MRPL24","ortholog_annotations":[{"gene_uniquename":"YMR193W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02071","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR193W"}


id: YMR194C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR194C-A"}


id: YMR194C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CMC4","product":"Protein that localizes to the mitochondrial intermembrane space; localizes via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs","secondary_identifier":"SGD:S000028514","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR194C-B"}


id: YMR194W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02121":null,"SJAG_03133":null,"YMR194W":null},"has_protein_features":false,"name":"RPL36A","ortholog_annotations":[{"gene_uniquename":"YMR194W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02121","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR194W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03133","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR194W"}


id: YMR195W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ICY1","product":"Protein of unknown function; required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation; ICY1 has a paralog, ATG41, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR195W"}


id: YMR196W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene","secondary_identifier":"SGD:S000004809","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR196W"}


id: YMR197C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04023":null,"YMR197C":null},"has_protein_features":false,"name":"VTI1","ortholog_annotations":[{"gene_uniquename":"YMR197C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04023","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways; human homolog VTI1A can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004810","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR197C"}


id: YMR198W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CIK1","product":"Kinesin-associated protein; required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; locus encodes a long and short transcript with differing functions; CIK1 has a paralog, VIK1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR198W"}


id: YMR199W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CLN1","product":"G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN1 has a paralog, CLN2, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1","secondary_identifier":"SGD:S000004812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR199W"}


id: YMR200W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05189":null,"YMR200W":null},"has_protein_features":false,"name":"ROT1","ortholog_annotations":[{"gene_uniquename":"YMR200W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05189","reference_uniquename":"PMID:29761456"}],"product":"Molecular chaperone involved in protein folding in ER; mutation causes defects in cell wall synthesis and lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation; transmembrane helix Ser250 is essential for Rot1p to interact with other membrane components and exert its functional role, avoiding exposure of Ser H-bonding group at lipid-exposed surface","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004813","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR200W"}


id: YMR201C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02334":null,"YMR201C":null},"has_protein_features":false,"name":"RAD14","ortholog_annotations":[{"gene_uniquename":"YMR201C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02334","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Nucleotide Excision Repair Factor 1 (NEF1); recognizes and binds damaged DNA during nucleotide excision repair (NER); also involved in regulation of transcription; contains zinc finger motif; homolog of human XPA protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004814","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR201C"}


id: YMR202W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03598":null,"YMR202W":null},"has_protein_features":false,"name":"ERG2","ortholog_annotations":[{"gene_uniquename":"YMR202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03598","reference_uniquename":"PMID:29761456"}],"product":"C-8 sterol isomerase; catalyzes isomerization of delta-8 double bond to delta-7 position at an intermediate step in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutation is functionally complemented by human EBP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004815","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR202W"}


id: YMR203W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03515":null,"YMR203W":null},"has_protein_features":false,"name":"TOM40","ortholog_annotations":[{"gene_uniquename":"YMR203W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03515","reference_uniquename":"PMID:29761456"}],"product":"Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore; pre-Tom40p is phosphorylated by PKA, which impairs its import into mitochondria under non-respiratory conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004816","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR203W"}


id: YMR204C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"INP1","product":"Peripheral membrane protein of peroxisomes; involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane; Inp1p and Pex3p tether peroxisomes to plasma membrane","secondary_identifier":"SGD:S000004817","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR204C"}


id: YMR205C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00605":null,"YMR205C":null},"has_protein_features":false,"name":"PFK2","ortholog_annotations":[{"gene_uniquename":"YMR205C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00605","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of heterooctameric phosphofructokinase; involved in glycolysis; indispensable for anaerobic growth; activated by fructose-2,6-bisphosphate and AMP; mutation inhibits glucose induction of cell cycle-related genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004818","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR205C"}


id: YMR206W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004819","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR206W"}


id: YMR207C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03313":null,"YMR207C":null},"has_protein_features":false,"name":"HFA1","ortholog_annotations":[{"gene_uniquename":"YMR207C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03313","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial acetyl-coenzyme A carboxylase; catalyzes production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress; genetic and comparative analysis suggests that translation begins at a non-canonical (Ile) start codon at -372 relative to the annotated start codon","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004820","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR207C"}


id: YMR208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04865":null,"YMR208W":null},"has_protein_features":false,"name":"ERG12","ortholog_annotations":[{"gene_uniquename":"YMR208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04865","reference_uniquename":"PMID:29761456"}],"product":"Mevalonate kinase; acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; human MVK functionally complements the lethality of the erg12 null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004821","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR208W"}


id: YMR209C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03087":null,"YMR209C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YMR209C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03087","reference_uniquename":"PMID:29761456"}],"product":"Putative S-adenosylmethionine-dependent methyltransferase; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YMR209C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004822","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR209C"}


id: YMR210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MGL2","product":"Monoacylglycerol and triacylglycerol lipase; MAG lipase with preference for palmitoyl-MAG; TAG lipase involved in TAG catabolism; minor role in medium-chain fatty acid ethyl ester biosynthesis; contains an alpha/beta hydrolase domain and a typical lipase motif (GXSXG); similar to acyltransferases, Eeb1p, Eht1p, and human ABHD1","secondary_identifier":"SGD:S000004823","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR210W"}


id: YMR211W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02265":null,"YMR211W":null},"has_protein_features":false,"name":"DML1","ortholog_annotations":[{"gene_uniquename":"YMR211W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02265","reference_uniquename":"PMID:29761456"}],"product":"Essential protein involved in mtDNA inheritance; may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004824","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR211W"}


id: YMR212C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04158":null,"SJAG_04930":null,"YMR212C":null},"has_protein_features":false,"name":"EFR3","ortholog_annotations":[{"gene_uniquename":"YMR212C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04158","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YMR212C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04930","reference_uniquename":"PMID:29761456"}],"product":"Protein required for Stt4-containing PI kinase complex localization; required for Stt4-containing phosphoinositide (PI) kinase patch assembly at plasma membrane; recruited to plasma membrane via conserved basic patch near N-terminus; exhibits synthetic lethal genetic interactions with PHO85; mutations in human homolog EFR3A implicated in autism spectrum disorders","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004825","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR212C"}


id: YMR213W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01408":null,"YMR213W":null},"has_protein_features":false,"name":"CEF1","ortholog_annotations":[{"gene_uniquename":"YMR213W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01408","reference_uniquename":"PMID:29761456"}],"product":"Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004826","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR213W"}


id: YMR214W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00403":null,"YMR214W":null},"has_protein_features":false,"name":"SCJ1","ortholog_annotations":[{"gene_uniquename":"YMR214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00403","reference_uniquename":"PMID:29761456"}],"product":"One of several homologs of bacterial chaperone DnaJ; located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004827","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR214W"}


id: YMR215W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01835":null,"YMR215W":null},"has_protein_features":false,"name":"GAS3","ortholog_annotations":[{"gene_uniquename":"YMR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01835","reference_uniquename":"PMID:26896847"}],"product":"Putative 1,3-beta-glucanosyltransferase; has similarity go other GAS family members; low abundance, possibly inactive member of the GAS family of GPI-containing proteins; localizes to the cell wall; mRNA induced during sporulation","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004828","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR215W"}


id: YMR216C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02058":null,"SJAG_05231":null,"YMR216C":null},"has_protein_features":false,"name":"SKY1","ortholog_annotations":[{"gene_uniquename":"YMR216C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02058","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR216C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05231","reference_uniquename":"PMID:26896847"}],"product":"SR protein kinase (SRPK); involved in mRNA 3' splice site recognition with Prp8p and Cdc40p; phosphorylates one or more SR dipeptides on mRNA export factors Npl3p and Gbp2p to stimulate cytoplasmic release of mRNA and Mtr10p-mediated nuclear reimport; component of stress granules that regulates granule disassembly during recovery from stress; modulates cation uptake and homeostasis through membrane transporters; contains prion-like domains; similar to human SRPK1","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004829","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR216C"}


id: YMR217W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04634":null,"YMR217W":null},"has_protein_features":false,"name":"GUA1","ortholog_annotations":[{"gene_uniquename":"YMR217W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04634","reference_uniquename":"PMID:29761456"}],"product":"GMP synthase; highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; reduction-of-function mutation gua1-G388D causes changes in cellular guanine nucleotide pools, defects in general protein synthesis, and impaired translation of GCN4 mRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004830","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR217W"}


id: YMR218C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02750":null,"YMR218C":null},"has_protein_features":false,"name":"TRS130","ortholog_annotations":[{"gene_uniquename":"YMR218C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02750","reference_uniquename":"PMID:29761456"}],"product":"Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004831","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR218C"}


id: YMR219W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ESC1","product":"Protein involved in telomeric silencing; required for quiescent cell telomere hypercluster localization at nuclear membrane vicinity; interacts with PAD4-domain of Sir4p","secondary_identifier":"SGD:S000004832","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR219W"}


id: YMR220W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01474":null,"YMR220W":null},"has_protein_features":false,"name":"ERG8","ortholog_annotations":[{"gene_uniquename":"YMR220W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01474","reference_uniquename":"PMID:29761456"}],"product":"Phosphomevalonate kinase; an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004833","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR220W"}


id: YMR221C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMP42","product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy","secondary_identifier":"SGD:S000004834","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR221C"}


id: YMR222C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03760":null,"YMR222C":null},"has_protein_features":false,"name":"FSH2","ortholog_annotations":[{"gene_uniquename":"YMR222C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03760","reference_uniquename":"PMID:29761456"}],"product":"Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004835","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR222C"}


id: YMR223W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03752":null,"YMR223W":null},"has_protein_features":false,"name":"UBP8","ortholog_annotations":[{"gene_uniquename":"YMR223W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03752","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-specific protease component of the SAGA acetylation complex; required for SAGA (Spt-Ada-Gcn5-Acetyltransferase)-mediated deubiquitination of histone H2B","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004836","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR223W"}


id: YMR224C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05373":null,"YMR224C":null},"has_protein_features":false,"name":"MRE11","ortholog_annotations":[{"gene_uniquename":"YMR224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05373","reference_uniquename":"PMID:29761456"}],"product":"Nuclease subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; Mre11p associates with Ser/Thr-rich ORFs in premeiotic phase; nuclease activity required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004837","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR224C"}


id: YMR225C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06110":null,"YMR225C":null},"has_protein_features":false,"name":"MRPL44","ortholog_annotations":[{"gene_uniquename":"YMR225C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06110","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004838","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR225C"}


id: YMR226C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01492":null,"SJAG_01690":null,"SJAG_01850":null,"SJAG_03492":null,"SJAG_04027":null,"YMR226C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YMR226C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01492","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR226C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01690","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR226C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01850","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR226C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03492","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR226C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04027","reference_uniquename":"PMID:29761456"}],"product":"NADP(+)-dependent serine dehydrogenase and carbonyl reductase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004839","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR226C"}


id: YMR227C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01808":null,"YMR227C":null},"has_protein_features":false,"name":"TAF7","ortholog_annotations":[{"gene_uniquename":"YMR227C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01808","reference_uniquename":"PMID:29761456"}],"product":"TFIID subunit (67 kDa); involved in RNA polymerase II transcription initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004840","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR227C"}


id: YMR228W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03289":null,"YMR228W":null},"has_protein_features":false,"name":"MTF1","ortholog_annotations":[{"gene_uniquename":"YMR228W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03289","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004841","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR228W"}


id: YMR229C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02530":null,"YMR229C":null},"has_protein_features":false,"name":"RRP5","ortholog_annotations":[{"gene_uniquename":"YMR229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02530","reference_uniquename":"PMID:29761456"}],"product":"RNA binding protein involved in synthesis of 18S and 5.8S rRNAs; component of ribosomal small subunit (SSU) processome and 90S preribosome; required for pre-rRNA packaging and compaction of processome into dense terminal balls; part of Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription with role in biogenesis of large ribosomal subunit; binds single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004842","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR229C"}


id: YMR230W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02904":null,"SJAG_04695":null,"YMR230W":null},"has_protein_features":false,"name":"RPS10B","ortholog_annotations":[{"gene_uniquename":"YMR230W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02904","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR230W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04695","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication; mutations in the human homolog associated with Diamond-Blackfan anemia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004843","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR230W"}


id: YMR230W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028576","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR230W-A"}


id: YMR231W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01772":null,"SJAG_04966":null,"YMR231W":null},"has_protein_features":false,"name":"PEP5","ortholog_annotations":[{"gene_uniquename":"YMR231W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01772","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR231W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04966","reference_uniquename":"PMID:29761456"}],"product":"Histone E3 ligase, component of CORVET membrane tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p; involved in ubiquitination and degradation of excess histones","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004844","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR231W"}


id: YMR232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02645":null,"SJAG_03581":null,"YMR232W":null},"has_protein_features":false,"name":"FUS2","ortholog_annotations":[{"gene_uniquename":"YMR232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02645","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03581","reference_uniquename":"PMID:29761456"}],"product":"Cell fusion regulator; cytoplasmic protein localized to shmoo tip; required for alignment of parental nuclei before nuclear fusion during mating; contains a Dbl-homology domain; binds specifically with activated Cdc42p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004845","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR232W"}


id: YMR233W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02747":null,"YMR233W":null},"has_protein_features":false,"name":"TRI1","ortholog_annotations":[{"gene_uniquename":"YMR233W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02747","reference_uniquename":"PMID:29761456"}],"product":"Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004846","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR233W"}


id: YMR234W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06022":null,"YMR234W":null},"has_protein_features":false,"name":"RNH1","ortholog_annotations":[{"gene_uniquename":"YMR234W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06022","reference_uniquename":"PMID:29761456"}],"product":"Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I.","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004847","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR234W"}


id: YMR235C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04400":null,"YMR235C":null},"has_protein_features":false,"name":"RNA1","ortholog_annotations":[{"gene_uniquename":"YMR235C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04400","reference_uniquename":"PMID:29761456"}],"product":"GTPase activating protein (GAP) for Gsp1p; involved in nuclear transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004848","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR235C"}


id: YMR236W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01475":null,"YMR236W":null},"has_protein_features":false,"name":"TAF9","ortholog_annotations":[{"gene_uniquename":"YMR236W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01475","reference_uniquename":"PMID:29761456"}],"product":"Subunit (17 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004849","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR236W"}


id: YMR237W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00916":null,"YMR237W":null},"has_protein_features":false,"name":"BCH1","ortholog_annotations":[{"gene_uniquename":"YMR237W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00916","reference_uniquename":"PMID:29761456"}],"product":"Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; interacts selectively with the activated, GTP-bound form of Arf1p; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004850","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR237W"}


id: YMR238W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00310":null,"SJAG_04850":null,"SJAG_04851":null,"SJAG_05272":null,"YMR238W":null},"has_protein_features":false,"name":"DFG5","ortholog_annotations":[{"gene_uniquename":"YMR238W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00310","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR238W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04850","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR238W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04851","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR238W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05272","reference_uniquename":"PMID:26896847"}],"product":"Putative mannosidase; essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004851","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR238W"}


id: YMR239C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02156":null,"SJAG_04527":null,"YMR239C":null},"has_protein_features":false,"name":"RNT1","ortholog_annotations":[{"gene_uniquename":"YMR239C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02156","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YMR239C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04527","reference_uniquename":"PMID:29761456"}],"product":"Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004852","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR239C"}


id: YMR240C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00322":null,"YMR240C":null},"has_protein_features":false,"name":"CUS1","ortholog_annotations":[{"gene_uniquename":"YMR240C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00322","reference_uniquename":"PMID:29761456"}],"product":"Protein required for assembly of U2 snRNP into the spliceosome; forms a complex with Hsh49p and Hsh155p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004853","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR240C"}


id: YMR241W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00275":null,"YMR241W":null},"has_protein_features":false,"name":"YHM2","ortholog_annotations":[{"gene_uniquename":"YMR241W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00275","reference_uniquename":"PMID:29761456"}],"product":"Citrate and oxoglutarate carrier protein; exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004854","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR241W"}


id: YMR242C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02283":null,"SJAG_04897":null,"YMR242C":null},"has_protein_features":false,"name":"RPL20A","ortholog_annotations":[{"gene_uniquename":"YMR242C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02283","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR242C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04897","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004855","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR242C"}


id: YMR242W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028694","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR242W-A"}


id: YMR243C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01078":null,"SJAG_01803":null,"YMR243C":null},"has_protein_features":false,"name":"ZRC1","ortholog_annotations":[{"gene_uniquename":"YMR243C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01078","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR243C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01803","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004856","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR243C"}


id: YMR244C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02229":null,"YMR244C-A":null},"has_protein_features":false,"name":"COA6","ortholog_annotations":[{"gene_uniquename":"YMR244C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02229","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in cytochrome c oxidase (Complex IV) assembly; involved in delivery of copper to Complex IV; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; ortholog implicated in cardiac defects in zebrafish and human; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004857","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR244C-A"}


id: YMR244W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02478":null,"YMR244W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YMR244W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02478","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004858","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR244W"}


id: YMR245W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004859","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR245W"}


id: YMR246W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03471":null,"SJAG_03909":null,"YMR246W":null},"has_protein_features":false,"name":"FAA4","ortholog_annotations":[{"gene_uniquename":"YMR246W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03471","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR246W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03909","reference_uniquename":"PMID:29761456"}],"product":"Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatty acids and sphingoid long-chain bases; role in stationary phase survival; localizes to lipid particles and the plasma membrane; role in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6, SLC27A2, or 4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004860","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR246W"}


id: YMR247C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00188":null,"YMR247C":null},"has_protein_features":false,"name":"RKR1","ortholog_annotations":[{"gene_uniquename":"YMR247C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00188","reference_uniquename":"PMID:29761456"}],"product":"RING domain E3 ubiquitin ligase; involved in ubiquitin-mediated degradation of non-stop proteins and translationally stalled ER membrane proteins; component of ribosome-bound RQC (ribosome quality control) complex; degrades products of mRNAs lacking a termination codon regardless of a poly(A) tail; functional connections to chromatin modification; homolog of mouse Listerin, mutations in which reported to cause neurodegeneration","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004861","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR247C"}


id: YMR247W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole","secondary_identifier":"SGD:S000028849","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR247W-A"}


id: YMR250W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GAD1","product":"Glutamate decarboxylase; converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress","secondary_identifier":"SGD:S000004862","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR250W"}


id: YMR251W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GTO3","product":"Omega class glutathione transferase; putative cytosolic localization","secondary_identifier":"SGD:S000004863","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR251W"}


id: YMR251W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HOR7","product":"Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004864","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR251W-A"}


id: YMR252C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MLO1","product":"Mitochondrial protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; MLO1 is not an essential gene","secondary_identifier":"SGD:S000004865","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR252C"}


id: YMR253C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene","secondary_identifier":"SGD:S000004866","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR253C"}


id: YMR254C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000004867","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR254C"}


id: YMR255W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GFD1","product":"Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004868","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR255W"}


id: YMR256C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05629":null,"YMR256C":null},"has_protein_features":false,"name":"COX7","ortholog_annotations":[{"gene_uniquename":"YMR256C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05629","reference_uniquename":"PMID:29761456"}],"product":"Subunit VII of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004869","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR256C"}


id: YMR257C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PET111","product":"Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane","secondary_identifier":"SGD:S000004870","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR257C"}


id: YMR258C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ROY1","product":"GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p","secondary_identifier":"SGD:S000004871","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR258C"}


id: YMR259C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04649":null,"YMR259C":null},"has_protein_features":false,"name":"TRM732","ortholog_annotations":[{"gene_uniquename":"YMR259C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04649","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in 2'-O-methylation of C32 of substrate tRNAs; interacts with 2'-O-ribose methyltransferase Trm7p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene; yeast null mutant can be functionally complemented by human THADA, mutations in which have been implicated in epithelial thyroid adenomas, type 2 diabetes, and polycystic ovary syndrome (PCOS)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004872","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR259C"}


id: YMR260C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01643":null,"YMR260C":null},"has_protein_features":false,"name":"TIF11","ortholog_annotations":[{"gene_uniquename":"YMR260C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01643","reference_uniquename":"PMID:29761456"}],"product":"Translation initiation factor eIF1A; essential protein that forms a complex with Sui1p (eIF1) and 40S ribosomal subunit and scans for start codons; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3; ortholog of bacterial translation initiation factor IF1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004873","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR260C"}


id: YMR261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00129":null,"SJAG_00182":null,"SJAG_01427":null,"YMR261C":null},"has_protein_features":false,"name":"TPS3","ortholog_annotations":[{"gene_uniquename":"YMR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00129","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00182","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YMR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01427","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004874","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR261C"}


id: YMR262W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03868":null,"YMR262W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YMR262W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03868","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004875","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR262W"}


id: YMR263W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SAP30","product":"Component of Rpd3L histone deacetylase complex; involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance","secondary_identifier":"SGD:S000004876","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR263W"}


id: YMR264W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01051":null,"YMR264W":null},"has_protein_features":false,"name":"CUE1","ortholog_annotations":[{"gene_uniquename":"YMR264W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01051","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-binding protein; ER membrane protein that recruits and integrates the ubiquitin-conjugating enzyme Ubc7p into ER membrane-bound ubiquitin ligase complexes that function in the ER-associated degradation (ERAD) pathway for misfolded proteins; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination and to promote diubiquitin elongation, facilitating polyubiquitin chain formation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004877","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR264W"}


id: YMR265C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02350":null,"YMR265C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YMR265C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02350","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004878","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR265C"}


id: YMR266W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02322":null,"YMR266W":null},"has_protein_features":false,"name":"RSN1","ortholog_annotations":[{"gene_uniquename":"YMR266W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02322","reference_uniquename":"PMID:29761456"}],"product":"Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004879","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR266W"}


id: YMR267W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01875":null,"YMR267W":null},"has_protein_features":false,"name":"PPA2","ortholog_annotations":[{"gene_uniquename":"YMR267W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01875","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inorganic pyrophosphatase; required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate; human ortholog, PPA2, functionally complements the null mutant; mutations in human PPA2 cause a mitochondrial disease resulting in sudden unexpected cardiac arrest in infants","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004880","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR267W"}


id: YMR268C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03214":null,"YMR268C":null},"has_protein_features":false,"name":"PRP24","ortholog_annotations":[{"gene_uniquename":"YMR268C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03214","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor that reanneals snRNPs during spliceosome recycling; reanneals U4 and U6 snRNPs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004881","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR268C"}


id: YMR268W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a protein; YMR268W-A was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YMR269W","secondary_identifier":"SGD:S000028577","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR268W-A"}


id: YMR269W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02775":null,"YMR269W":null},"has_protein_features":false,"name":"TMA23","ortholog_annotations":[{"gene_uniquename":"YMR269W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02775","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004882","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR269W"}


id: YMR270C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04083":null,"YMR270C":null},"has_protein_features":false,"name":"RRN9","ortholog_annotations":[{"gene_uniquename":"YMR270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04083","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004883","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR270C"}


id: YMR271C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00694":null,"YMR271C":null},"has_protein_features":false,"name":"URA10","ortholog_annotations":[{"gene_uniquename":"YMR271C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00694","reference_uniquename":"PMID:29761456"}],"product":"Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004884","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR271C"}


id: YMR272C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04913":null,"YMR272C":null},"has_protein_features":false,"name":"SCS7","ortholog_annotations":[{"gene_uniquename":"YMR272C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04913","reference_uniquename":"PMID:29761456"}],"product":"Sphingolipid alpha-hydroxylase; functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004885","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR272C"}


id: YMR272W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene SCS7/YMR272C","secondary_identifier":"SGD:S000028695","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR272W-A"}


id: YMR272W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole","secondary_identifier":"SGD:S000028696","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR272W-B"}


id: YMR273C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01901":null,"YMR273C":null},"has_protein_features":false,"name":"ZDS1","ortholog_annotations":[{"gene_uniquename":"YMR273C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01901","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004886","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR273C"}


id: YMR274C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00730":null,"YMR274C":null},"has_protein_features":false,"name":"RCE1","ortholog_annotations":[{"gene_uniquename":"YMR274C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00730","reference_uniquename":"PMID:29761456"}],"product":"Type II CAAX prenyl protease; involved in the proteolysis and maturation of Ras and the a-factor mating pheromone","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004887","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR274C"}


id: YMR275C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUL1","product":"Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex; ubiquitin-binding adaptor involved in down-regulation of general amino acid transporter Gap1p upon shift to preferred nitrogen source; involved in lactate transporter Jen1p endocytosis; BUL1 has a paralog, BUL2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004888","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR275C"}


id: YMR276W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07000":null,"YMR276W":null},"has_protein_features":false,"name":"DSK2","ortholog_annotations":[{"gene_uniquename":"YMR276W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07000","reference_uniquename":"PMID:29761456"}],"product":"Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004889","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR276W"}


id: YMR277W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01286":null,"YMR277W":null},"has_protein_features":false,"name":"FCP1","ortholog_annotations":[{"gene_uniquename":"YMR277W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01286","reference_uniquename":"PMID:29761456"}],"product":"Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004890","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR277W"}


id: YMR278W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00134":null,"YMR278W":null},"has_protein_features":false,"name":"PRM15","ortholog_annotations":[{"gene_uniquename":"YMR278W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00134","reference_uniquename":"PMID:29761456"}],"product":"Phosphoribomutase; catalyzes interconversion of ribose-1-phosphate and ribose-5-phosphate; has some phosphoglucomutase activity but primary activity in vivo is phosphoribomutase; contributes to ribose recycling in the pentose phosphate pathway; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004891","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR278W"}


id: YMR279C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATR2","product":"Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004892","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR279C"}


id: YMR280C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CAT8","product":"Zinc cluster transcriptional activator; necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000004893","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR280C"}


id: YMR281W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01416":null,"YMR281W":null},"has_protein_features":false,"name":"GPI12","ortholog_annotations":[{"gene_uniquename":"YMR281W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01416","reference_uniquename":"PMID:29761456"}],"product":"ER membrane protein involved in the second step of GPI anchor assembly; the second step is the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp; GPI stands for glycosylphosphatidylinositol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004894","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR281W"}


id: YMR282C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03674":null,"YMR282C":null},"has_protein_features":false,"name":"AEP2","ortholog_annotations":[{"gene_uniquename":"YMR282C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03674","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein; likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004895","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR282C"}


id: YMR283C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05228":null,"YMR283C":null},"has_protein_features":false,"name":"RIT1","ortholog_annotations":[{"gene_uniquename":"YMR283C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05228","reference_uniquename":"PMID:29761456"}],"product":"Initiator methionine 2'-O-ribosyl phosphate transferase; modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004896","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR283C"}


id: YMR284W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05372":null,"YMR284W":null},"has_protein_features":false,"name":"YKU70","ortholog_annotations":[{"gene_uniquename":"YMR284W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05372","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein to nucleus via interaction with the TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004897","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR284W"}


id: YMR285C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04519":null,"YMR285C":null},"has_protein_features":false,"name":"NGL2","ortholog_annotations":[{"gene_uniquename":"YMR285C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04519","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004898","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR285C"}


id: YMR286W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06253":null,"YMR286W":null},"has_protein_features":false,"name":"MRPL33","ortholog_annotations":[{"gene_uniquename":"YMR286W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06253","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004899","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR286W"}


id: YMR287C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06586":null,"YMR287C":null},"has_protein_features":false,"name":"DSS1","ortholog_annotations":[{"gene_uniquename":"YMR287C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06586","reference_uniquename":"PMID:29761456"}],"product":"3'-5' exoribonuclease; component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004900","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR287C"}


id: YMR288W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01008":null,"YMR288W":null},"has_protein_features":false,"name":"HSH155","ortholog_annotations":[{"gene_uniquename":"YMR288W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01008","reference_uniquename":"PMID:29761456"}],"product":"U2-snRNP associated splicing factor; forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004901","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR288W"}


