# genes

id: YJR135W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02524":null,"YJR135W-A":null},"has_protein_features":false,"name":"TIM8","ortholog_annotations":[{"gene_uniquename":"YJR135W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02524","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial intermembrane space protein; forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome, also known as deafness-dystonia-optic neuronopathy (DDON) syndrome; human TIMM8A can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007348","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR135W-A"}


id: YJR136C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05206":null,"YJR136C":null},"has_protein_features":false,"name":"TTI2","ortholog_annotations":[{"gene_uniquename":"YJR136C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05206","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; involved in the cellular stress response; similar to S. pombe Tti2p; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003897","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR136C"}


id: YJR137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05027":null,"YJR137C":null},"has_protein_features":false,"name":"MET5","ortholog_annotations":[{"gene_uniquename":"YJR137C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05027","reference_uniquename":"PMID:29761456"}],"product":"Sulfite reductase beta subunit; involved in amino acid biosynthesis, transcription repressed by methionine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003898","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR137C"}


id: YJR138W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00824":null,"YJR138W":null},"has_protein_features":false,"name":"IML1","ortholog_annotations":[{"gene_uniquename":"YJR138W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00824","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy, and is a subcomplex of the SEA, a coatomer-related complex that associates with the vacuole; Iml1p functions as a GAP for the Rag family GTPase Gtr1p (EGOC subunit) in SEACIT, resulting in the inhibition of TORC1 signaling in response to amino acid deprivation; role in the oxidative stress response","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003899","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR138W"}


id: YJR139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03152":null,"YJR139C":null},"has_protein_features":false,"name":"HOM6","ortholog_annotations":[{"gene_uniquename":"YJR139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03152","reference_uniquename":"PMID:29761456"}],"product":"Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase); dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003900","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR139C"}


id: YJR140C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00914":null,"YJR140C":null},"has_protein_features":false,"name":"HIR3","ortholog_annotations":[{"gene_uniquename":"YJR140C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00914","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003901","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR140C"}


id: YJR140W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene HIR3; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028666","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR140W-A"}


id: YJR141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00435":null,"YJR141W":null},"has_protein_features":false,"name":"IPA1","ortholog_annotations":[{"gene_uniquename":"YJR141W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00435","reference_uniquename":"PMID:29761456"}],"product":"Protein implicated in pre-mRNA processing and proteasomal degradation; interacts physically and genetically with mRNA cleavage and polyadenylation factors; mutant is impaired in pre-mRNA cleavage and polyadenylation; associates with several Ub-conjugating enzymes and alters Ub-mediated proteasome activity; localizes to both the nucleus and cytosol; contains a HECT_2 domain; homologous to human ubiquitin-protein ligase, UBE3D, a gene implicated in age-related macular degeneration","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003902","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR141W"}


id: YJR142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03362":null,"YJR142W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJR142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03362","reference_uniquename":"PMID:29761456"}],"product":"8-oxo-dGTP diphosphatase of the Nudix hydrolase family; converts diphosphates of damaged forms of thiamin to monophosphates; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003903","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR142W"}


id: YJR143C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01491":null,"YJR143C":null},"has_protein_features":false,"name":"PMT4","ortholog_annotations":[{"gene_uniquename":"YJR143C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01491","reference_uniquename":"PMID:29761456"}],"product":"Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003904","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR143C"}


id: YJR144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03068":null,"YJR144W":null},"has_protein_features":false,"name":"MGM101","ortholog_annotations":[{"gene_uniquename":"YJR144W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03068","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in mitochondrial DNA recombinational repair; also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage and mitochondrial genome maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003905","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR144W"}


id: YJR145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04324":null,"SJAG_04663":null,"YJR145C":null},"has_protein_features":false,"name":"RPS4A","ortholog_annotations":[{"gene_uniquename":"YJR145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04324","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04663","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003906","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR145C"}


id: YJR146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2","secondary_identifier":"SGD:S000003907","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR146W"}


id: YJR147W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HMS2","product":"Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003908","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR147W"}


id: YJR148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04149":null,"YJR148W":null},"has_protein_features":false,"name":"BAT2","ortholog_annotations":[{"gene_uniquename":"YJR148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04149","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase; BAT2 has a paralog, BAT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003909","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR148W"}


id: YJR149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000003910","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR149W"}


id: YJR150C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DAN1","product":"Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth","secondary_identifier":"SGD:S000003911","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR150C"}


id: YJR151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DAN4","product":"Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth","secondary_identifier":"SGD:S000003912","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR151C"}


id: YJR151W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational 'guilt by association' analysis","secondary_identifier":"SGD:S000028557","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR151W-A"}


id: YJR152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02139":null,"SJAG_05182":null,"YJR152W":null},"has_protein_features":false,"name":"DAL5","ortholog_annotations":[{"gene_uniquename":"YJR152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02139","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05182","reference_uniquename":"PMID:29761456"}],"product":"Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003913","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR152W"}


id: YJR153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PGU1","product":"Endo-polygalacturonase; pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins","secondary_identifier":"SGD:S000003914","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR153W"}


id: YJR154W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000003915","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR154W"}


id: YJR155W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AAD10","product":"Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family","secondary_identifier":"SGD:S000003916","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR155W"}


id: YJR156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04866":null,"YJR156C":null},"has_protein_features":false,"name":"THI11","ortholog_annotations":[{"gene_uniquename":"YJR156C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04866","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003917","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR156C"}


id: YJR157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003918","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR157W"}


id: YJR158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YJR158W":null},"has_protein_features":false,"name":"HXT16","ortholog_annotations":[{"gene_uniquename":"YJR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003919","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR158W"}


id: YJR159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00237":null,"YJR159W":null},"has_protein_features":false,"name":"SOR1","ortholog_annotations":[{"gene_uniquename":"YJR159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00237","reference_uniquename":"PMID:29761456"}],"product":"Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor2p sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003920","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR159W"}


id: YJR160C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MPH3","product":"Alpha-glucoside permease; transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication","secondary_identifier":"SGD:S000003921","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR160C"}


id: YJR161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS5","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000003922","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR161C"}


id: YJR162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003923","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR162C"}


id: YKL001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00084":null,"YKL001C":null},"has_protein_features":false,"name":"MET14","ortholog_annotations":[{"gene_uniquename":"YKL001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00084","reference_uniquename":"PMID:29761456"}],"product":"Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001484","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL001C"}


id: YKL002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04489":null,"YKL002W":null},"has_protein_features":false,"name":"DID4","ortholog_annotations":[{"gene_uniquename":"YKL002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04489","reference_uniquename":"PMID:29761456"}],"product":"Class E Vps protein of the ESCRT-III complex; required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001485","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL002W"}


id: YKL003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01468":null,"YKL003C":null},"has_protein_features":false,"name":"MRP17","ortholog_annotations":[{"gene_uniquename":"YKL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01468","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001486","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL003C"}


id: YKL003W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a discrete protein; YKL003W-A was added based on homology to closely related fungi, but was later withdrawn because it was completely contained within DID4/YKL002W","secondary_identifier":"SGD:S000007614","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL003W-A"}


id: YKL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00506":null,"YKL004W":null},"has_protein_features":false,"name":"AUR1","ortholog_annotations":[{"gene_uniquename":"YKL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00506","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol:ceramide phosphoinositol transferase; required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance; also known as IPC synthase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001487","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL004W"}


id: YKL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01707":null,"YKL005C":null},"has_protein_features":false,"name":"BYE1","ortholog_annotations":[{"gene_uniquename":"YKL005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01707","reference_uniquename":"PMID:29761456"}],"product":"Negative regulator of transcription elongation; contains a TFIIS-like domain that associates with chromatin and a PHD domain that interacts with H3K4me3; multicopy suppressor of temperature-sensitive ess1 mutations, binds RNA polymerase II large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001488","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL005C"}


id: YKL006C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00804":null,"YKL006C-A":null},"has_protein_features":false,"name":"SFT1","ortholog_annotations":[{"gene_uniquename":"YKL006C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00804","reference_uniquename":"PMID:29761456"}],"product":"Intra-Golgi v-SNARE; required for transport of proteins between an early and a later Golgi compartment","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002101","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL006C-A"}


id: YKL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01364":null,"SJAG_02890":null,"YKL006W":null},"has_protein_features":false,"name":"RPL14A","ortholog_annotations":[{"gene_uniquename":"YKL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01364","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02890","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001489","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL006W"}


id: YKL007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01894":null,"YKL007W":null},"has_protein_features":false,"name":"CAP1","ortholog_annotations":[{"gene_uniquename":"YKL007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01894","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001490","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL007W"}


id: YKL008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02085":null,"SJAG_02842":null,"YKL008C":null},"has_protein_features":false,"name":"LAC1","ortholog_annotations":[{"gene_uniquename":"YKL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02085","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02842","reference_uniquename":"PMID:29761456"}],"product":"Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p; LAC1 has a paralog, LAG1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001491","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL008C"}


id: YKL009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03466":null,"YKL009W":null},"has_protein_features":false,"name":"MRT4","ortholog_annotations":[{"gene_uniquename":"YKL009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03466","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in mRNA turnover and ribosome assembly; required at post-transcriptional step for efficient retrotransposition; localizes to the nucleolus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001492","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL009W"}


id: YKL010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01900":null,"YKL010C":null},"has_protein_features":false,"name":"UFD4","ortholog_annotations":[{"gene_uniquename":"YKL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01900","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; involved in K29-linked ubiquitin-dependent protein catabolism, including ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001493","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL010C"}


id: YKL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04752":null,"YKL011C":null},"has_protein_features":false,"name":"CCE1","ortholog_annotations":[{"gene_uniquename":"YKL011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04752","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial cruciform cutting endonuclease; cleaves Holliday junctions formed during recombination of mitochondrial DNA; CCE1 has a paralog, MRS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001494","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL011C"}


id: YKL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01654":null,"YKL012W":null},"has_protein_features":false,"name":"PRP40","ortholog_annotations":[{"gene_uniquename":"YKL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01654","reference_uniquename":"PMID:29761456"}],"product":"U1 snRNP protein involved in splicing; interacts with the branchpoint-binding protein during the formation of the second commitment complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001495","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL012W"}


id: YKL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02245":null,"YKL013C":null},"has_protein_features":false,"name":"ARC19","ortholog_annotations":[{"gene_uniquename":"YKL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02245","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; mutation is functionally complemented by human ARPC4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001496","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL013C"}


id: YKL014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04289":null,"YKL014C":null},"has_protein_features":false,"name":"URB1","ortholog_annotations":[{"gene_uniquename":"YKL014C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04289","reference_uniquename":"PMID:29761456"}],"product":"Protein required for the normal accumulation of 25S and 5.8S rRNAs; nucleolar protein; associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001497","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL014C"}


id: YKL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02709":null,"YKL015W":null},"has_protein_features":false,"name":"PUT3","ortholog_annotations":[{"gene_uniquename":"YKL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02709","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional activator; binds specific gene recruitment sequences and is required for DNA zip code-mediated targeting of genes to nuclear periphery; regulates proline utilization genes, constitutively binds PUT1 and PUT2 promoters as a dimer, undergoes conformational change to form active state; binds other promoters only under activating conditions; differentially phosphorylated in presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001498","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL015W"}


id: YKL016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03925":null,"YKL016C":null},"has_protein_features":false,"name":"ATP7","ortholog_annotations":[{"gene_uniquename":"YKL016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03925","reference_uniquename":"PMID:29761456"}],"product":"Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001499","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL016C"}


id: YKL017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03495":null,"YKL017C":null},"has_protein_features":false,"name":"HCS1","ortholog_annotations":[{"gene_uniquename":"YKL017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03495","reference_uniquename":"PMID:29761456"}],"product":"Hexameric DNA polymerase alpha-associated DNA helicase A; involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001500","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL017C"}


id: YKL018C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MCO12","product":"Putative mitochondrial protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000007615","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL018C-A"}


id: YKL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01599":null,"SJAG_03431":null,"YKL018W":null},"has_protein_features":false,"name":"SWD2","ortholog_annotations":[{"gene_uniquename":"YKL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01599","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03431","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex; required for Set1C stability and optimal activity; COMPASS methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001501","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL018W"}


id: YKL019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04923":null,"YKL019W":null},"has_protein_features":false,"name":"RAM2","ortholog_annotations":[{"gene_uniquename":"YKL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04923","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I; farnesyltransferase (Ram2p-Ram1p heterodimer) catalyzes the addition of 15-carbon isoprenoid farnesyl to substrate proteins containing a CAAX consensus motif; type I geranylgeranyltransferase (Ram2p-Cdc43p heterodimer) catalyzes the addition of the 20-carbon isoprenoid geranylgeranyl to substrate proteins containing a CaaL consensus motif; required for membrane localization of Ras proteins and a-factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001502","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL019W"}


id: YKL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02196":null,"YKL020C":null},"has_protein_features":false,"name":"SPT23","ortholog_annotations":[{"gene_uniquename":"YKL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02196","reference_uniquename":"PMID:29761456"}],"product":"ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; SPT23 has a paralog, MGA2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001503","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL020C"}


id: YKL021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01821":null,"YKL021C":null},"has_protein_features":false,"name":"MAK11","ortholog_annotations":[{"gene_uniquename":"YKL021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01821","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in an early step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001504","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL021C"}


id: YKL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03350":null,"YKL022C":null},"has_protein_features":false,"name":"CDC16","ortholog_annotations":[{"gene_uniquename":"YKL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03350","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the anaphase-promoting complex/cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001505","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL022C"}


id: YKL023C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIN9","product":"Mitochondrial protein of unknown function","secondary_identifier":"SGD:S000113559","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL023C-A"}


id: YKL023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SKA1","product":"SKI complex-associated protein; involved in 3'-5' degradation of long 3'UTR-containing mRNA, poorly translated mRNA, and other RNA regions devoid of ribosomes; proposed to assist the cytoplasmic exosome in a Ska1-SKI complex when a direct interaction between the ribosome and the SKI complex is absent","secondary_identifier":"SGD:S000001506","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL023W"}


id: YKL024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00779":null,"YKL024C":null},"has_protein_features":false,"name":"URA6","ortholog_annotations":[{"gene_uniquename":"YKL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00779","reference_uniquename":"PMID:29761456"}],"product":"Uridylate kinase; catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001507","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL024C"}


id: YKL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01910":null,"SJAG_02808":null,"YKL025C":null},"has_protein_features":false,"name":"PAN3","ortholog_annotations":[{"gene_uniquename":"YKL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01910","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02808","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; poly (A) mRNA binding subunit which recruits mRNA to the complex; the Pan2p-Pan3p complex controls poly(A) tail length and regulates the stoichiometry and activity of postreplication repair complexes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001508","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL025C"}


id: YKL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01216":null,"YKL026C":null},"has_protein_features":false,"name":"GPX1","ortholog_annotations":[{"gene_uniquename":"YKL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01216","reference_uniquename":"PMID:29761456"}],"product":"Phospholipid hydroperoxide glutathione peroxidase; induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; glutathione peroxidase activity is neuroprotective in models of Huntington's disease; GPX1 has a paralog, HYR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001509","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL026C"}


id: YKL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02084":null,"YKL027W":null},"has_protein_features":false,"name":"TCD2","ortholog_annotations":[{"gene_uniquename":"YKL027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02084","reference_uniquename":"PMID:29761456"}],"product":"tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD2 has a paralog, TCD1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001510","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL027W"}


id: YKL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00116":null,"YKL028W":null},"has_protein_features":false,"name":"TFA1","ortholog_annotations":[{"gene_uniquename":"YKL028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00116","reference_uniquename":"PMID:29761456"}],"product":"TFIIE large subunit; involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001511","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL028W"}


id: YKL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02176":null,"YKL029C":null},"has_protein_features":false,"name":"MAE1","ortholog_annotations":[{"gene_uniquename":"YKL029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02176","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001512","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL029C"}


id: YKL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1","secondary_identifier":"SGD:S000001513","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL030W"}


id: YKL031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species","secondary_identifier":"SGD:S000001514","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL031W"}


id: YKL032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00634":null,"YKL032C":null},"has_protein_features":false,"name":"IXR1","ortholog_annotations":[{"gene_uniquename":"YKL032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00634","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional repressor that regulates hypoxic genes during normoxia; involved in the aerobic repression of genes such as COX5b, TIR1, and HEM13; binds DNA intrastrand cross-links formed by cisplatin; HMG (high mobility group box) domain containing protein which binds and bends cisplatin-modified DNA, blocking excision repair; IXR1 has a paralog, ABF2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001515","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL032C"}


id: YKL033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03267":null,"YKL033W":null},"has_protein_features":false,"name":"TTI1","ortholog_annotations":[{"gene_uniquename":"YKL033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03267","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001516","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL033W"}


id: YKL033W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04264":null,"SJAG_05029":null,"YKL033W-A":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YKL033W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04264","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL033W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05029","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; similar to uncharacterized proteins from other fungi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL033W-A"}


id: YKL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04151":null,"YKL034W":null},"has_protein_features":false,"name":"TUL1","ortholog_annotations":[{"gene_uniquename":"YKL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04151","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001517","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL034W"}


id: YKL035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01089":null,"SJAG_02178":null,"YKL035W":null},"has_protein_features":false,"name":"UGP1","ortholog_annotations":[{"gene_uniquename":"YKL035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01089","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02178","reference_uniquename":"PMID:29761456"}],"product":"UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; involved in PKA-mediated oxidative stress resistance and long-term survival in stationary phase; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001518","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL035W"}


id: YKL036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W","secondary_identifier":"SGD:S000001519","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL036C"}


id: YKL037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM26","product":"Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT","secondary_identifier":"SGD:S000001520","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL037W"}


id: YKL038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01930":null,"YKL038W":null},"has_protein_features":false,"name":"RGT1","ortholog_annotations":[{"gene_uniquename":"YKL038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01930","reference_uniquename":"PMID:29761456"}],"product":"Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; recruits Tup1p/Cyc8p to target gene promoters; RGT1 has a paralog, EDS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL038W"}


id: YKL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02193":null,"SJAG_02823":null,"YKL039W":null},"has_protein_features":false,"name":"PTM1","ortholog_annotations":[{"gene_uniquename":"YKL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02193","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02823","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL039W"}


id: YKL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03222":null,"YKL040C":null},"has_protein_features":false,"name":"NFU1","ortholog_annotations":[{"gene_uniquename":"YKL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03222","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress; acts along with Bol3 at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to client proteins; Fe-S loaded homodimer at steady state; similar to NifU, a bacterial protein required for Fe/S cluster maturation; ortholog of the human NFU1, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS1)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL040C"}


id: YKL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03783":null,"YKL041W":null},"has_protein_features":false,"name":"VPS24","ortholog_annotations":[{"gene_uniquename":"YKL041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03783","reference_uniquename":"PMID:29761456"}],"product":"One of four subunits of the ESCRT-III complex; forms an endosomal sorting complex required for transport III (ESCRT-III) subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001524","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL041W"}


id: YKL042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPC42","product":"Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane","secondary_identifier":"SGD:S000001525","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL042W"}


id: YKL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PHD1","product":"Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL043W"}


id: YKL044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MMO1","product":"Protein of unknown function; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the mitochondria; mRNA identified as translated by ribosome profiling data; MMO1 is a non-essential gene","secondary_identifier":"SGD:S000001527","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL044W"}


id: YKL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02627":null,"YKL045W":null},"has_protein_features":false,"name":"PRI2","ortholog_annotations":[{"gene_uniquename":"YKL045W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02627","reference_uniquename":"PMID:29761456"}],"product":"Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001528","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL045W"}


id: YKL046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00310":null,"SJAG_04850":null,"SJAG_04851":null,"SJAG_05272":null,"YKL046C":null},"has_protein_features":false,"name":"DCW1","ortholog_annotations":[{"gene_uniquename":"YKL046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00310","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YKL046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04850","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YKL046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04851","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YKL046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05272","reference_uniquename":"PMID:29761456"}],"product":"Putative mannosidase; GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001529","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL046C"}


id: YKL047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04532":null,"YKL047W":null},"has_protein_features":false,"name":"ANR2","ortholog_annotations":[{"gene_uniquename":"YKL047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04532","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; may have a role in lipid metabolism, based on localization to lipid droplets; predicted to be palmitoylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001530","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL047W"}


id: YKL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ELM1","product":"Serine/threonine protein kinase; regulates the orientation checkpoint, the morphogenesis checkpoint and the metabolic switch from fermentative to oxidative metabolism by phosphorylating the activation loop of Kin4p, Hsl1p and Snf1p respectively; cooperates with Hsl7p in recruiting Hsl1p to the septin ring, a prerequisite for subsequent recruitment, phosphorylation, and degradation of Swe1p; forms part of the bud neck ring; regulates cytokinesis","secondary_identifier":"SGD:S000001531","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL048C"}


id: YKL049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00307":null,"YKL049C":null},"has_protein_features":false,"name":"CSE4","ortholog_annotations":[{"gene_uniquename":"YKL049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00307","reference_uniquename":"PMID:29761456"}],"product":"Centromeric histone H3-like protein; associates with promoters, accessible chromatin and RNAPII-bound regions; centromeric association promotes kinetochore assembly and Sgo1p association with CEN chromatin; Ipl1p-dependent phosphorylation destabilizes defective kinetochores promoting biorientation; phosphorylation by Cdc7p maintains Cse4p at kinetochores and promotes chromosome segregation; R37 methylation regulates kinetochore function and chromosome segregation; complements human homolog CENPA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001532","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL049C"}


id: YKL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04227":null,"YKL050C":null},"has_protein_features":false,"name":"LPX2","ortholog_annotations":[{"gene_uniquename":"YKL050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04227","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal matrix-localized lipase; target of SCFCdc4 ubiquitin ligase complex; peroxisomal, nuclear and cytosolic localization is dependent on the presence of oleate; transcription is regulated by Azf1p; LPX2 has a paralog, EIS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001533","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL050C"}


id: YKL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04225":null,"YKL051W":null},"has_protein_features":false,"name":"SFK1","ortholog_annotations":[{"gene_uniquename":"YKL051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04225","reference_uniquename":"PMID:29761456"}],"product":"Protein that regulates phospholipid asymmetry at plasma membrane; may act to generate normal levels of PI4P; may act together with or upstream of Stt4p; at least partially mediates proper localization of Stt4p to the plasma membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001534","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL051W"}


id: YKL052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00918":null,"YKL052C":null},"has_protein_features":false,"name":"ASK1","ortholog_annotations":[{"gene_uniquename":"YKL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00918","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; sumoylated in an Mms21p-dependent manner; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001535","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL052C"}


id: YKL053C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06440":null,"YKL053C-A":null},"has_protein_features":false,"name":"MDM35","ortholog_annotations":[{"gene_uniquename":"YKL053C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06440","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial intermembrane space protein; forms complex with Ups2p that transfers phosphatidylserine from outer membrane to inner membrane for phosphatidylethanolamine synthesis; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL053C-A"}


id: YKL053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1","secondary_identifier":"SGD:S000001536","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL053W"}


id: YKL054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02116":null,"YKL054C":null},"has_protein_features":false,"name":"DEF1","ortholog_annotations":[{"gene_uniquename":"YKL054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02116","reference_uniquename":"PMID:29761456"}],"product":"RNAPII degradation factor; forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; interacts with general transcription factor TFIIH; mutant is deficient in Zip1p loading onto chromosomes during meiosis; null mutant is prone to self-diploidization; null mutation can be functionally complemented by human UBAP2 and UBAP2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001537","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL054C"}


id: YKL055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03198":null,"YKL055C":null},"has_protein_features":false,"name":"OAR1","ortholog_annotations":[{"gene_uniquename":"YKL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03198","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase; may comprise a type II mitochondrial fatty acid synthase along with Mct1p; human homolog CBR4 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001538","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL055C"}


id: YKL056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02786":null,"YKL056C":null},"has_protein_features":false,"name":"TMA19","ortholog_annotations":[{"gene_uniquename":"YKL056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02786","reference_uniquename":"PMID:29761456"}],"product":"Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress; homolog of human TPT1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001539","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL056C"}


id: YKL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04017":null,"YKL057C":null},"has_protein_features":false,"name":"NUP120","ortholog_annotations":[{"gene_uniquename":"YKL057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04017","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001540","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL057C"}


id: YKL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02174":null,"YKL058W":null},"has_protein_features":false,"name":"TOA2","ortholog_annotations":[{"gene_uniquename":"YKL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02174","reference_uniquename":"PMID:29761456"}],"product":"TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa1p, for ribosomal protein gene transcription in vivo; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001541","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL058W"}


id: YKL059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02668":null,"YKL059C":null},"has_protein_features":false,"name":"MPE1","ortholog_annotations":[{"gene_uniquename":"YKL059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02668","reference_uniquename":"PMID:29761456"}],"product":"Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase; detects polyadenylation signal in nascent pre-mRNA and triggers 3' end formation of mRNA via cleavage and polyadenylation; binds pre-mRNA via zinc knuckle and RING finger; E3 ubiquitin ligase involved in polyubiquitination of endonuclease Ysh1p; contains a ubiquitin-like (UBL) domain, a RNA-binding zinc knuckle motif and a RING finger domain; relocalizes to cytosol in response to hypoxia; homolog of human RBBP6","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001542","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL059C"}


id: YKL060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01310":null,"SJAG_03373":null,"YKL060C":null},"has_protein_features":false,"name":"FBA1","ortholog_annotations":[{"gene_uniquename":"YKL060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01310","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03373","reference_uniquename":"PMID:29761456"}],"product":"Fructose 1,6-bisphosphate aldolase; required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress; N-terminally propionylated in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001543","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL060C"}


id: YKL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BLI1","product":"Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; green fluorescent protein (GFP)-fusion protein localizes to the endosome","secondary_identifier":"SGD:S000001544","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL061W"}


id: YKL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03388":null,"YKL062W":null},"has_protein_features":false,"name":"MSN4","ortholog_annotations":[{"gene_uniquename":"YKL062W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03388","reference_uniquename":"PMID:29761456"}],"product":"Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes, inducing gene expression; involved in diauxic shift","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001545","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL062W"}


id: YKL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi","secondary_identifier":"SGD:S000001546","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL063C"}


id: YKL064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02578":null,"YKL064W":null},"has_protein_features":false,"name":"MNR2","ortholog_annotations":[{"gene_uniquename":"YKL064W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02578","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001547","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL064W"}


id: YKL065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03244":null,"YKL065C":null},"has_protein_features":false,"name":"YET1","ortholog_annotations":[{"gene_uniquename":"YKL065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03244","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein; YET1 has a paralog, YET2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001548","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL065C"}


id: YKL065W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DPC7","product":"Protein of unknown function; SWAT-GFP fusion protein localizes to endoplasmic reticulum (ER) while mCherry fusion localizes to both ER and vacuole","secondary_identifier":"SGD:S000113563","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL065W-A"}


id: YKL066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1","secondary_identifier":"SGD:S000001549","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL066W"}


id: YKL067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02887":null,"YKL067W":null},"has_protein_features":false,"name":"YNK1","ortholog_annotations":[{"gene_uniquename":"YKL067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02887","reference_uniquename":"PMID:29761456"}],"product":"Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001550","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL067W"}


id: YKL068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03299":null,"YKL068W":null},"has_protein_features":false,"name":"NUP100","ortholog_annotations":[{"gene_uniquename":"YKL068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03299","reference_uniquename":"PMID:26896847"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier and is involved in gene tethering at the nuclear periphery; NUP100 has a paralog, NUP116, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001551","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL068W"}


id: YKL068W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by homology to <i>Ashbya gossypii</i>","secondary_identifier":"SGD:S000028524","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL068W-A"}


id: YKL069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; capable of binding and degrading patulin, a polyketide mycotoxin, forming E-ascladiol; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000001552","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL069W"}


id: YKL070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000001553","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL070W"}


id: YKL071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OSI1","product":"NADH-dependent short-chain aldehyde reductase; involved in detoxification of furfural; expression is upregulated in cells treated with the aldehydes furfural and glycolaldehyde, the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000001554","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL071W"}


id: YKL072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STB6","product":"Protein that binds Sin3p in a two-hybrid assay; STB6 has a paralog, STB2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001555","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL072W"}


id: YKL073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02875":null,"YKL073W":null},"has_protein_features":false,"name":"LHS1","ortholog_annotations":[{"gene_uniquename":"YKL073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02875","reference_uniquename":"PMID:29761456"}],"product":"Molecular chaperone of the endoplasmic reticulum lumen; involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001556","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL073W"}


id: YKL074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03995":null,"YKL074C":null},"has_protein_features":false,"name":"MUD2","ortholog_annotations":[{"gene_uniquename":"YKL074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03995","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001557","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL074C"}


id: YKL075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AAN1","product":"Protein of unknown function; regulates actin cable stability and branched-chain amino acid (BCAA) metabolism; involved in mitochondrial quality control and longevity; proposed to be involved in resistance to streptozotocin and camptothecin; localizes to punctate cytosolic structures","secondary_identifier":"SGD:S000001558","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL075C"}


id: YKL076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PSY1","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C","secondary_identifier":"SGD:S000001559","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL076C"}


id: YKL077W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00484":null,"SJAG_04419":null,"YKL077W":null},"has_protein_features":false,"name":"PSG1","ortholog_annotations":[{"gene_uniquename":"YKL077W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00484","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL077W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04419","reference_uniquename":"PMID:29761456"}],"product":"Protein that promotes the transport and maturation of Pma1 with Exp1; cleaved specifically by Kex2p; localizes to the Golgi apparatus and to the endoplasmic reticulum in HTP studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001560","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL077W"}


id: YKL078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03897":null,"YKL078W":null},"has_protein_features":false,"name":"DHR2","ortholog_annotations":[{"gene_uniquename":"YKL078W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03897","reference_uniquename":"PMID:29761456"}],"product":"Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001561","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL078W"}


id: YKL079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00332":null,"YKL079W":null},"has_protein_features":false,"name":"SMY1","ortholog_annotations":[{"gene_uniquename":"YKL079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00332","reference_uniquename":"PMID:29761456"}],"product":"Kinesin-like myosin passenger-protein; interacts with Myo2p and enhances its interaction with Sec4p during transport of secretory vesicles; controls actin cable structure and dynamics","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001562","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL079W"}


id: YKL080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01397":null,"YKL080W":null},"has_protein_features":false,"name":"VMA5","ortholog_annotations":[{"gene_uniquename":"YKL080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01397","reference_uniquename":"PMID:29761456"}],"product":"Subunit C of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001563","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL080W"}


id: YKL081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02017":null,"SJAG_03863":null,"YKL081W":null},"has_protein_features":false,"name":"TEF4","ortholog_annotations":[{"gene_uniquename":"YKL081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02017","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03863","reference_uniquename":"PMID:29761456"}],"product":"Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001564","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL081W"}


id: YKL082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02475":null,"SJAG_04562":null,"YKL082C":null},"has_protein_features":false,"name":"RRP14","ortholog_annotations":[{"gene_uniquename":"YKL082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02475","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04562","reference_uniquename":"PMID:29761456"}],"product":"Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001565","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL082C"}


id: YKL083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14","secondary_identifier":"SGD:S000001566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL083W"}


id: YKL084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01560":null,"YKL084W":null},"has_protein_features":false,"name":"HOT13","ortholog_annotations":[{"gene_uniquename":"YKL084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01560","reference_uniquename":"PMID:29761456"}],"product":"Zinc-binding mitochondrial intermembrane space (IMS) protein; involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001567","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL084W"}


id: YKL085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01753":null,"YKL085W":null},"has_protein_features":false,"name":"MDH1","ortholog_annotations":[{"gene_uniquename":"YKL085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01753","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated; mutation in human homolog MDH2 causes early-onset severe encephalopathy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001568","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL085W"}


id: YKL086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04125":null,"YKL086W":null},"has_protein_features":false,"name":"SRX1","ortholog_annotations":[{"gene_uniquename":"YKL086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04125","reference_uniquename":"PMID:29761456"}],"product":"Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001569","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL086W"}


id: YKL087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03199":null,"SJAG_04008":null,"YKL087C":null},"has_protein_features":false,"name":"CYT2","ortholog_annotations":[{"gene_uniquename":"YKL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03199","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04008","reference_uniquename":"PMID:26896847"}],"product":"Cytochrome c1 heme lyase; involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; human homolog HCCS can complement yeast cyt2 null mutant","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001570","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL087C"}


id: YKL088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CAB3","product":"Subunit of PPCDC and CoA-SPC complexes involved in CoA biosynthesis; subunits of the phosphopantothenoylcysteine decarboxylase (PPCDC) complex are: Cab3p, Sis2p, Vhs3p, while the subunits of the CoA-synthesizing protein complex (CoA-SPC) are: Cab2p, Cab3p, Cab4p, and Cab5p as well as Sis2p and Vhs3p; null mutant lethality is complemented by E. coli coaBC","secondary_identifier":"SGD:S000001571","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL088W"}


id: YKL089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03217":null,"YKL089W":null},"has_protein_features":false,"name":"MIF2","ortholog_annotations":[{"gene_uniquename":"YKL089W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03217","reference_uniquename":"PMID:29761456"}],"product":"Centromeric CDEIII region binding protein; nucleates kinetochore assembly; required for the structural integrity of elongating spindles; copurifies with subunits of the MIND complex and centromeric nucleosome components (Cse4p and histones H2A, H2B, and H4); phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3; localizes to the kinetochore","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001572","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL089W"}


id: YKL090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01936":null,"YKL090W":null},"has_protein_features":false,"name":"CUE2","ortholog_annotations":[{"gene_uniquename":"YKL090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01936","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-binding endonuclease involved in mRNA decay; recruited to stalled ribosomes to promote breakdown of transcript body of nuclear-transcribed mRNA with stalls in translation elongation; cleaves mRNA within A site of colliding ribosome; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001573","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL090W"}


id: YKL091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03746":null,"YKL091C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YKL091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03746","reference_uniquename":"PMID:29761456"}],"product":"Putative phosphatidylinositol/phosphatidylcholine transfer protein; possibly involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study; YKL091C has a paralog, SEC14, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001574","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL091C"}


id: YKL092C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUD2","product":"GTPase activating factor for Rsr1p/Bud1p; plays a role in spindle position checkpoint distinct from its role in bud site selection; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; contains two PH-like domains","secondary_identifier":"SGD:S000001575","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL092C"}


id: YKL093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MBR1","product":"Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; MBR1 has a paralog, ISF1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001576","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL093W"}


id: YKL094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02543":null,"YKL094W":null},"has_protein_features":false,"name":"YJU3","ortholog_annotations":[{"gene_uniquename":"YKL094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02543","reference_uniquename":"PMID:29761456"}],"product":"Monoglyceride lipase (MGL) that hydrolyzes fatty acid ethyl esters; required for removal of toxic metabolites in ethanol producing yeast cells; localizes to lipid particles and membranes; member of the eukaryotic serine hydrolase family; functional ortholog of mammalian MGL","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001577","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL094W"}


id: YKL095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01504":null,"SJAG_03427":null,"YKL095W":null},"has_protein_features":false,"name":"YJU2","ortholog_annotations":[{"gene_uniquename":"YKL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01504","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03427","reference_uniquename":"PMID:26896847"}],"product":"Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ('nineteen complex') and acts after Prp2p to promote the first catalytic reaction of splicing","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001578","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL095W"}


id: YKL096C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028667","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL096C-B"}


id: YKL096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CWP1","product":"Cell wall mannoprotein that localizes to birth scars of daughter cells; linked to beta-1,3- and beta-1,6-glucan heteropolymer through phosphodiester bond; required for propionic acid resistance; targeted to vacuole via AP-3 pathway","secondary_identifier":"SGD:S000001579","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL096W"}


id: YKL096W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CWP2","product":"Covalently linked cell wall mannoprotein; major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored","secondary_identifier":"SGD:S000001956","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL096W-A"}


id: YKL097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; not conserved in closely related Saccharomyces species","secondary_identifier":"SGD:S000001580","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL097C"}


id: YKL098W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MTC2","product":"Protein of unknown function; mtc2 is synthetically sick with cdc13-1","secondary_identifier":"SGD:S000001581","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL098W"}


id: YKL099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02025":null,"YKL099C":null},"has_protein_features":false,"name":"UTP11","ortholog_annotations":[{"gene_uniquename":"YKL099C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02025","reference_uniquename":"PMID:29761456"}],"product":"Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001582","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL099C"}


id: YKL100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04583":null,"YKL100C":null},"has_protein_features":false,"name":"YPF1","ortholog_annotations":[{"gene_uniquename":"YKL100C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04583","reference_uniquename":"PMID:29761456"}],"product":"Intramembrane aspartyl protease of the perinuclear ER membrane; acts in a branch of ER-associated degradation (ERAD) that degrades functional proteins rather than misfolded proteins; regulates abundance of high-affinity plasma membrane transporters, such as Ctr1p and Zrt1p, during the starvation response; has a presenilin fold; member of the GxGD family of intramembrane proteases; closest human homolog is signal peptide peptidase (SPP)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001583","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL100C"}


id: YKL100W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028840","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL100W-A"}


id: YKL101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03602":null,"SJAG_04486":null,"YKL101W":null},"has_protein_features":false,"name":"HSL1","ortholog_annotations":[{"gene_uniquename":"YKL101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03602","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04486","reference_uniquename":"PMID:29761456"}],"product":"Nim1p-related protein kinase; septin-binding kinase that localizes to the bud neck septin ring and regulates the morphogenesis checkpoint; phosphorylates Hsl7p and cooperates with Elm1p to recruit Hsl7p to the mother-bud neck, as a prerequisite for the subsequent recruitment, phosphorylation, and degradation of Swe1p; autophosphorylation enhances interactions with Hsl7p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001584","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL101W"}


id: YKL102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site","secondary_identifier":"SGD:S000001585","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL102C"}


id: YKL103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"APE1","product":"Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to peptidase family M18; often used as marker in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via CVT pathway","secondary_identifier":"SGD:S000001586","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL103C"}


id: YKL104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04728":null,"YKL104C":null},"has_protein_features":false,"name":"GFA1","ortholog_annotations":[{"gene_uniquename":"YKL104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04728","reference_uniquename":"PMID:29761456"}],"product":"Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL104C"}


id: YKL104W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Novel ORF identified by enrichment-based proteomics","secondary_identifier":"SGD:S000303811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL104W-A"}


id: YKL105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SEG2","product":"Eisosome component; likely plays only a minor role in eisosome assembly; shown to interact with Seg1p by affinity purification and mass spec; SWAT-GFP and mCherry fusion proteins localize to the cell periphery; similar to <i>A. gossypii</i> SEG gene which is important for stabilizing eisosomes; SEG2 has a paralog, SEG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001588","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL105C"}


id: YKL106C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi","secondary_identifier":"SGD:S000007616","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL106C-A"}


id: YKL106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00714":null,"YKL106W":null},"has_protein_features":false,"name":"AAT1","ortholog_annotations":[{"gene_uniquename":"YKL106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00714","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001589","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL106W"}


id: YKL107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"NADH-dependent aldehyde reductase; involved in the detoxification of acetaldehyde, glycolaldehyde, furfural, formaldehyde and propionaldehyde; localizes to the endoplasmic reticulum; member of the classical short-chain dehydrogenase/reductase (SDR) family","secondary_identifier":"SGD:S000001590","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL107W"}


id: YKL108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04995":null,"YKL108W":null},"has_protein_features":false,"name":"SLD2","ortholog_annotations":[{"gene_uniquename":"YKL108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04995","reference_uniquename":"PMID:29761456"}],"product":"Single-stranded DNA origin-binding and annealing protein; required for initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; binds the Mcm2-7p complex to prevent inappropriate Mcm2-7p interaction with the GINS complex in G1; required for S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001591","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL108W"}


id: YKL109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04607":null,"YKL109W":null},"has_protein_features":false,"name":"HAP4","ortholog_annotations":[{"gene_uniquename":"YKL109W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04607","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor; subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex; involved in diauxic shift","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001592","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL109W"}


id: YKL110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01024":null,"YKL110C":null},"has_protein_features":false,"name":"KTI12","ortholog_annotations":[{"gene_uniquename":"YKL110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01024","reference_uniquename":"PMID:29761456"}],"product":"Protein that plays a role in modification of tRNA wobble nucleosides; protein plays role in tRNA wobble nucleoside modification with Elongator complex; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001593","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL110C"}


id: YKL111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1","secondary_identifier":"SGD:S000001594","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL111C"}


id: YKL112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ABF1","product":"DNA binding protein with possible chromatin-reorganizing activity; involved in transcriptional activation, gene silencing, and DNA replication and repair","secondary_identifier":"SGD:S000001595","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL112W"}


id: YKL113C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01648":null,"YKL113C":null},"has_protein_features":false,"name":"RAD27","ortholog_annotations":[{"gene_uniquename":"YKL113C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01648","reference_uniquename":"PMID:29761456"}],"product":"5' to 3' exonuclease, 5' flap endonuclease; required for Okazaki fragment processing and maturation, for long-patch base-excision repair and large loop repair (LLR), ribonucleotide excision repair; cleaves off RNA flap in a RNA:DNA hybrid intermediate during processing of DNA lagging strand; relocalizes to the cytosol in response to hypoxia; member of the S. pombe RAD2/FEN1 family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001596","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL113C"}


id: YKL114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03665":null,"YKL114C":null},"has_protein_features":false,"name":"APN1","ortholog_annotations":[{"gene_uniquename":"YKL114C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03665","reference_uniquename":"PMID:29761456"}],"product":"Major apurinic/apyrimidinic endonuclease; 3'-repair diesterase; involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine; genetically interacts with NTG1 to maintain mitochondrial genome integrity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001597","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL114C"}


id: YKL115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRR1","secondary_identifier":"SGD:S000001598","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL115C"}


id: YKL116C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRR1","product":"Serine/threonine protein kinase; inhibits pheromone induced signaling downstream of MAPK, possibly at the level of the Ste12p transcription factor","secondary_identifier":"SGD:S000001599","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL116C"}


id: YKL117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03784":null,"YKL117W":null},"has_protein_features":false,"name":"SBA1","ortholog_annotations":[{"gene_uniquename":"YKL117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03784","reference_uniquename":"PMID:29761456"}],"product":"Co-chaperone that binds and regulates Hsp90 family chaperones; plays a role in determining prion variants; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001600","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL117W"}


id: YKL118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPH2","secondary_identifier":"SGD:S000001601","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL118W"}


id: YKL119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06514":null,"YKL119C":null},"has_protein_features":false,"name":"VPH2","ortholog_annotations":[{"gene_uniquename":"YKL119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06514","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER); involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001602","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL119C"}


id: YKL120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00671":null,"YKL120W":null},"has_protein_features":false,"name":"OAC1","ortholog_annotations":[{"gene_uniquename":"YKL120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00671","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane transporter; transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001603","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL120W"}


id: YKL121W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01563":null,"SJAG_03432":null,"YKL121W":null},"has_protein_features":false,"name":"DGR2","ortholog_annotations":[{"gene_uniquename":"YKL121W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01563","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL121W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03432","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds; DGR2 has a paralog, YMR102C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001604","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL121W"}


id: YKL122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03411":null,"YKL122C":null},"has_protein_features":false,"name":"SRP21","ortholog_annotations":[{"gene_uniquename":"YKL122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03411","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the signal recognition particle (SRP); SRP functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001605","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL122C"}


id: YKL123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SSH4","secondary_identifier":"SGD:S000001606","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL123W"}


id: YKL124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01586":null,"YKL124W":null},"has_protein_features":false,"name":"SSH4","ortholog_annotations":[{"gene_uniquename":"YKL124W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01586","reference_uniquename":"PMID:29761456"}],"product":"Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001607","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL124W"}


id: YKL125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01744":null,"YKL125W":null},"has_protein_features":false,"name":"RRN3","ortholog_annotations":[{"gene_uniquename":"YKL125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01744","reference_uniquename":"PMID:29761456"}],"product":"Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL125W"}


id: YKL126W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04206":null,"YKL126W":null},"has_protein_features":false,"name":"YPK1","ortholog_annotations":[{"gene_uniquename":"YKL126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04206","reference_uniquename":"PMID:29761456"}],"product":"S/T protein kinase; required for PM lipid and protein homeostasis; involved in sphingolipid-mediated and cell integrity signaling pathways and endocytosis; phosphorylates and downregulates Fpk1p; phosphorylates and inactivates Orm1p/2p when sphingolipid synthesis is compromised; role in TORC1/2-dependent Rps6a/b phosphorylation; phosphorylated and activated by TORC2 and by Pkh1/2p in the presence of phytosphingosine; human homolog SGK1 complements the null and inviability of a ypk1 ypk2 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL126W"}


id: YKL127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01209":null,"YKL127W":null},"has_protein_features":false,"name":"PGM1","ortholog_annotations":[{"gene_uniquename":"YKL127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01209","reference_uniquename":"PMID:29761456"}],"product":"Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; PGM1 has a paralog, PGM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001610","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL127W"}


id: YKL128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02984":null,"SJAG_03714":null,"YKL128C":null},"has_protein_features":false,"name":"PMU1","ortholog_annotations":[{"gene_uniquename":"YKL128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02984","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03714","reference_uniquename":"PMID:29761456"}],"product":"Putative phosphomutase; contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant; localizes to cytosol an peroxisomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001611","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL128C"}


id: YKL129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04001":null,"YKL129C":null},"has_protein_features":false,"name":"MYO3","ortholog_annotations":[{"gene_uniquename":"YKL129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04001","reference_uniquename":"PMID:29761456"}],"product":"One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO3 has a paralog, MYO5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001612","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL129C"}


id: YKL130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SHE2","product":"RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; binds to ER-derived membranes and targets mRNAs to cortical ER","secondary_identifier":"SGD:S000001613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL130C"}


id: YKL131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001614","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL131W"}


id: YKL132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00529":null,"YKL132C":null},"has_protein_features":false,"name":"RMA1","ortholog_annotations":[{"gene_uniquename":"YKL132C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00529","reference_uniquename":"PMID:29761456"}],"product":"Putative dihydrofolate synthetase; similar to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; RMA1 has a paralog, FOL3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001615","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL132C"}


id: YKL133C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00354":null,"YKL133C":null},"has_protein_features":false,"name":"RCI50","ortholog_annotations":[{"gene_uniquename":"YKL133C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00354","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein of unknown function; not required for growth of cells lacking the mitochondrial genome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; YKL133C has a paralog, MGR3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001616","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL133C"}


id: YKL134C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01004":null,"YKL134C":null},"has_protein_features":false,"name":"OCT1","ortholog_annotations":[{"gene_uniquename":"YKL134C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01004","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial intermediate peptidase; cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001617","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL134C"}


id: YKL135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02453":null,"SJAG_04565":null,"YKL135C":null},"has_protein_features":false,"name":"APL2","ortholog_annotations":[{"gene_uniquename":"YKL135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02453","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YKL135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04565","reference_uniquename":"PMID:29761456"}],"product":"Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001618","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL135C"}


id: YKL136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C","secondary_identifier":"SGD:S000001619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL136W"}


id: YKL137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01140":null,"SJAG_05398":null,"YKL137W":null},"has_protein_features":false,"name":"CMC1","ortholog_annotations":[{"gene_uniquename":"YKL137W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01140","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL137W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05398","reference_uniquename":"PMID:29761456"}],"product":"Copper-binding protein of the mitochondrial intermembrane space; evolutionarily conserved; may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001620","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL137W"}


id: YKL138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04216":null,"YKL138C":null},"has_protein_features":false,"name":"MRPL31","ortholog_annotations":[{"gene_uniquename":"YKL138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04216","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001621","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL138C"}


id: YKL138C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02731":null,"YKL138C-A":null},"has_protein_features":false,"name":"HSK3","ortholog_annotations":[{"gene_uniquename":"YKL138C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02731","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL138C-A"}


id: YKL139W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03967":null,"YKL139W":null},"has_protein_features":false,"name":"CTK1","ortholog_annotations":[{"gene_uniquename":"YKL139W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03967","reference_uniquename":"PMID:29761456"}],"product":"Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; required for H3K36 trimethylation but not dimethylation by Set2p; suggested stimulatory role in 80S formation during translation initiation; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001622","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL139W"}


id: YKL140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00158":null,"SJAG_02068":null,"SJAG_04790":null,"YKL140W":null},"has_protein_features":false,"name":"TGL1","ortholog_annotations":[{"gene_uniquename":"YKL140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00158","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02068","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04790","reference_uniquename":"PMID:29761456"}],"product":"Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001623","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL140W"}


id: YKL141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03920":null,"YKL141W":null},"has_protein_features":false,"name":"SDH3","ortholog_annotations":[{"gene_uniquename":"YKL141W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03920","reference_uniquename":"PMID:29761456"}],"product":"Subunit of succinate dehydrogenase and of TIM22 translocase; functions as cytochrome b subunit of succinate dehydrogenase, which couples oxidation of succinate to transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex; SDH3 has a paralog, SHH3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001624","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL141W"}


id: YKL142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03489":null,"YKL142W":null},"has_protein_features":false,"name":"MRP8","ortholog_annotations":[{"gene_uniquename":"YKL142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03489","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001625","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL142W"}


id: YKL143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01338":null,"YKL143W":null},"has_protein_features":false,"name":"LTV1","ortholog_annotations":[{"gene_uniquename":"YKL143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01338","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the EGO/GSE complex; the vacuolar/endosomal membrane associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from the endosome to the plasma membrane; required for ribosomal small subunit export from nucleus; required for growth at low temperature","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL143W"}


id: YKL144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02600":null,"YKL144C":null},"has_protein_features":false,"name":"RPC25","ortholog_annotations":[{"gene_uniquename":"YKL144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02600","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase III subunit C25; required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL144C"}


id: YKL145W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01489":null,"YKL145W":null},"has_protein_features":false,"name":"RPT1","ortholog_annotations":[{"gene_uniquename":"YKL145W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01489","reference_uniquename":"PMID:29761456"}],"product":"ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL145W"}


id: YKL145W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified essential gene RPT1; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028841","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL145W-A"}


id: YKL146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03400":null,"YKL146W":null},"has_protein_features":false,"name":"AVT3","ortholog_annotations":[{"gene_uniquename":"YKL146W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03400","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar transporter; exports large neutral amino acids from vacuole; targeted to vacuole via AP-3 pathway; member of family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL146W"}


id: YKL147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3","secondary_identifier":"SGD:S000001630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL147C"}


id: YKL148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01671":null,"YKL148C":null},"has_protein_features":false,"name":"SDH1","ortholog_annotations":[{"gene_uniquename":"YKL148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01671","reference_uniquename":"PMID:29761456"}],"product":"Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits; mutations in human ortholog SDHA are associated with Leigh syndrome and predisposition to several cancers","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL148C"}


id: YKL149C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01433":null,"YKL149C":null},"has_protein_features":false,"name":"DBR1","ortholog_annotations":[{"gene_uniquename":"YKL149C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01433","reference_uniquename":"PMID:29761456"}],"product":"RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies; human homolog DBR1 can complement yeast dbr1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL149C"}


id: YKL150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MCR1","product":"Mitochondrial NADH-cytochrome b5 reductase; involved in ergosterol biosynthesis","secondary_identifier":"SGD:S000001633","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL150W"}


id: YKL151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03669":null,"YKL151C":null},"has_protein_features":false,"name":"NNR2","ortholog_annotations":[{"gene_uniquename":"YKL151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03669","reference_uniquename":"PMID:29761456"}],"product":"Widely-conserved NADHX dehydratase; converts (S)-NADHX to NADH in ATP-dependent manner; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; downstream intergenic region drives antisense expression and mediates coordinated regulation of YKL151C and GPM1 phosphoglycerate mutase; protein abundance increases in response to DNA replication stress; homolog of Carkd in mammals and C-terminus of YjeF in E.coli","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001634","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL151C"}


id: YKL152C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02009":null,"YKL152C":null},"has_protein_features":false,"name":"GPM1","ortholog_annotations":[{"gene_uniquename":"YKL152C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02009","reference_uniquename":"PMID:29761456"}],"product":"Tetrameric phosphoglycerate mutase; mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001635","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL152C"}


id: YKL153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant","secondary_identifier":"SGD:S000001636","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL153W"}


id: YKL154W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00360":null,"YKL154W":null},"has_protein_features":false,"name":"SRP102","ortholog_annotations":[{"gene_uniquename":"YKL154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00360","reference_uniquename":"PMID:29761456"}],"product":"Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001637","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL154W"}


id: YKL155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03322":null,"YKL155C":null},"has_protein_features":false,"name":"RSM22","ortholog_annotations":[{"gene_uniquename":"YKL155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03322","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent RNA methyltransferase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL155C"}


id: YKL156C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene RPS27A; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028668","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL156C-A"}


id: YKL156W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02340":null,"YKL156W":null},"has_protein_features":false,"name":"RPS27A","ortholog_annotations":[{"gene_uniquename":"YKL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02340","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001639","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL156W"}


id: YKL157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00181":null,"YKL157W":null},"has_protein_features":false,"name":"APE2","ortholog_annotations":[{"gene_uniquename":"YKL157W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00181","reference_uniquename":"PMID:29761456"}],"product":"Aminopeptidase yscII; may have role in obtaining leucine from dipeptide substrates; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; APE2 has a paralog, AAP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001640","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL157W"}


id: YKL158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YKL158W was originally annotated as an independent ORF, but was later demonstrated to be an exon of an adjacent ORF, YKL157W","secondary_identifier":"SGD:S000028807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL158W"}


id: YKL159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04871":null,"YKL159C":null},"has_protein_features":false,"name":"RCN1","ortholog_annotations":[{"gene_uniquename":"YKL159C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04871","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL159C"}


id: YKL160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04353":null,"YKL160W":null},"has_protein_features":false,"name":"ELF1","ortholog_annotations":[{"gene_uniquename":"YKL160W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04353","reference_uniquename":"PMID:29761456"}],"product":"Transcription elongation factor with a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL160W"}


id: YKL161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"KDX1","product":"Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL161C"}


id: YKL162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion","secondary_identifier":"SGD:S000001645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL162C"}


id: YKL162C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL162C-A"}


id: YKL163W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PIR3","product":"O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; coding sequence contains length polymorphisms in different strains; PIR3 has a paralog, HSP150, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL163W"}


id: YKL164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PIR1","product":"O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL164C"}


id: YKL165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04165":null,"YKL165C":null},"has_protein_features":false,"name":"MCD4","ortholog_annotations":[{"gene_uniquename":"YKL165C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04165","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in GPI anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes; GPI stands for glycosylphosphatidylinositol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001648","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL165C"}


id: YKL165C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007617","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL165C-A"}


id: YKL166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04312":null,"YKL166C":null},"has_protein_features":false,"name":"TPK3","ortholog_annotations":[{"gene_uniquename":"YKL166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04312","reference_uniquename":"PMID:29761456"}],"product":"cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001649","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL166C"}


id: YKL167C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05270":null,"YKL167C":null},"has_protein_features":false,"name":"MRP49","ortholog_annotations":[{"gene_uniquename":"YKL167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05270","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001650","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL167C"}


id: YKL168C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"KKQ8","product":"Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL168C"}


id: YKL169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38","secondary_identifier":"SGD:S000001652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL169C"}


id: YKL170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00315":null,"YKL170W":null},"has_protein_features":false,"name":"MRPL38","ortholog_annotations":[{"gene_uniquename":"YKL170W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00315","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001653","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL170W"}


id: YKL171W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04655":null,"YKL171W":null},"has_protein_features":false,"name":"NNK1","ortholog_annotations":[{"gene_uniquename":"YKL171W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04655","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001654","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL171W"}


id: YKL172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03413":null,"YKL172W":null},"has_protein_features":false,"name":"EBP2","ortholog_annotations":[{"gene_uniquename":"YKL172W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03413","reference_uniquename":"PMID:29761456"}],"product":"Protein required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL172W"}


id: YKL173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00414":null,"YKL173W":null},"has_protein_features":false,"name":"SNU114","ortholog_annotations":[{"gene_uniquename":"YKL173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00414","reference_uniquename":"PMID:29761456"}],"product":"GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL173W"}


id: YKL174C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00015":null,"SJAG_00019":null,"SJAG_01096":null,"SJAG_02062":null,"SJAG_02113":null,"SJAG_02133":null,"SJAG_02144":null,"SJAG_02941":null,"SJAG_04135":null,"SJAG_04673":null,"SJAG_06598":null,"YKL174C":null},"has_protein_features":false,"name":"TPO5","ortholog_annotations":[{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00015","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00019","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01096","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02062","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02113","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02133","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02144","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02941","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04135","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04673","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06598","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL174C"}


id: YKL175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01990":null,"YKL175W":null},"has_protein_features":false,"name":"ZRT3","ortholog_annotations":[{"gene_uniquename":"YKL175W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01990","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane zinc transporter; transports zinc from storage in vacuole to cytoplasm when needed; transcription induced under conditions of zinc deficiency; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL175W"}


id: YKL176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04910":null,"YKL176C":null},"has_protein_features":false,"name":"LST4","ortholog_annotations":[{"gene_uniquename":"YKL176C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04910","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino acid stimulation; required for activation of TORC1 in response to amino acid stimulation; recruited to the vacuolar membrane during amino acid starvation and released from the membrane by TORC1; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL176C"}


id: YKL177W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3","secondary_identifier":"SGD:S000001660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL177W"}


id: YKL178C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01345":null,"YKL178C":null},"has_protein_features":false,"name":"STE3","ortholog_annotations":[{"gene_uniquename":"YKL178C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01345","reference_uniquename":"PMID:29761456"}],"product":"Receptor for a factor pheromone; couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL178C"}


id: YKL179C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02316":null,"YKL179C":null},"has_protein_features":false,"name":"COY1","ortholog_annotations":[{"gene_uniquename":"YKL179C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02316","reference_uniquename":"PMID:29761456"}],"product":"Golgi membrane protein with similarity to mammalian CASP; packaged into COPII vesicles for trafficking between ER and Golgi; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL179C"}


id: YKL180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00940":null,"SJAG_01721":null,"YKL180W":null},"has_protein_features":false,"name":"RPL17A","ortholog_annotations":[{"gene_uniquename":"YKL180W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00940","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL180W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01721","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L17A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001663","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL180W"}


id: YKL181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04970":null,"YKL181W":null},"has_protein_features":false,"name":"PRS1","ortholog_annotations":[{"gene_uniquename":"YKL181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04970","reference_uniquename":"PMID:29761456"}],"product":"5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; plays a key role in cell wall integrity (CWI) pathway; one of five related enzymes, which are active as heteromultimeric complexes; missense mutations in human homolog PRPS1 are associated with neuropathic Arts syndrome and Charcot-Marie Tooth (CMTX5) disease","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001664","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL181W"}


id: YKL182W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04107":null,"YKL182W":null},"has_protein_features":false,"name":"FAS1","ortholog_annotations":[{"gene_uniquename":"YKL182W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04107","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities; specific target of the broad-spectrum antifungal NPD6433","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001665","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL182W"}


id: YKL183C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028558","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL183C-A"}


id: YKL183W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03279":null,"YKL183W":null},"has_protein_features":false,"name":"LOT5","ortholog_annotations":[{"gene_uniquename":"YKL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03279","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001666","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL183W"}


id: YKL184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00043":null,"YKL184W":null},"has_protein_features":false,"name":"SPE1","ortholog_annotations":[{"gene_uniquename":"YKL184W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00043","reference_uniquename":"PMID:29761456"}],"product":"Ornithine decarboxylase; catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001667","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL184W"}


id: YKL185W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ASH1","product":"Component of the Rpd3L histone deacetylase complex; zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate","secondary_identifier":"SGD:S000001668","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL185W"}


id: YKL186C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04721":null,"YKL186C":null},"has_protein_features":false,"name":"MTR2","ortholog_annotations":[{"gene_uniquename":"YKL186C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04721","reference_uniquename":"PMID:29761456"}],"product":"mRNA transport regulator; essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL186C"}


id: YKL187C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FAT3","product":"Protein required for fatty acid uptake; protein abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; FAT3 has a paralog, YLR413W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001670","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL187C"}


id: YKL188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PXA2","product":"Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant","secondary_identifier":"SGD:S000001671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL188C"}


id: YKL189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00333":null,"YKL189W":null},"has_protein_features":false,"name":"HYM1","ortholog_annotations":[{"gene_uniquename":"YKL189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00333","reference_uniquename":"PMID:29761456"}],"product":"Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis; interacts with Sog2p; allosterically activates Kic1p; localizes to sites of polarized growth during budding and during the mating response","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL189W"}


id: YKL190W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03793":null,"YKL190W":null},"has_protein_features":false,"name":"CNB1","ortholog_annotations":[{"gene_uniquename":"YKL190W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03793","reference_uniquename":"PMID:29761456"}],"product":"Calcineurin B; regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (stress-response transcription factor); other calcineurin subunit encoded by CNA1 and/or CMP1; regulates function of Aly1p alpha-arrestin; myristoylation by Nmt1p reduces calcineurin activity in response to submaximal Ca signals, is needed to prevent constitutive phosphatase activity; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL190W"}


id: YKL191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04085":null,"YKL191W":null},"has_protein_features":false,"name":"DPH2","ortholog_annotations":[{"gene_uniquename":"YKL191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04085","reference_uniquename":"PMID:29761456"}],"product":"Protein required for synthesis of diphthamide; required along with Dph1p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); forms a complex with Dph1p that catalyzes the first step of diphthamide biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001674","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL191W"}


id: YKL192C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01238":null,"YKL192C":null},"has_protein_features":false,"name":"ACP1","ortholog_annotations":[{"gene_uniquename":"YKL192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01238","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial matrix acyl carrier protein; involved in biosynthesis of octanoate, which is a precursor to lipoic acid; coordinates mitochondrial fatty acid and iron sulfur cluster metabolism; activated by phosphopantetheinylation catalyzed by Ppt2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001675","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL192C"}


id: YKL193C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04968":null,"YKL193C":null},"has_protein_features":false,"name":"SDS22","ortholog_annotations":[{"gene_uniquename":"YKL193C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04968","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL193C"}


id: YKL194C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03585":null,"YKL194C":null},"has_protein_features":false,"name":"MST1","ortholog_annotations":[{"gene_uniquename":"YKL194C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03585","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(UAG)Q2 in vitro; lacks a typical editing domain, but has pre-transfer editing activity stimulated by the unusual tRNA-Thr","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL194C"}


id: YKL195W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00196":null,"YKL195W":null},"has_protein_features":false,"name":"MIA40","ortholog_annotations":[{"gene_uniquename":"YKL195W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00196","reference_uniquename":"PMID:29761456"}],"product":"Import and assembly protein in mitochondrial intermembrane space; component of MIA pathway which mediates import and oxidative folding of substrates including small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p via a chaperone-like activity; forms a dimer that binds iron-sulfur cluster in vitro","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL195W"}


id: YKL196C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00899":null,"YKL196C":null},"has_protein_features":false,"name":"YKT6","ortholog_annotations":[{"gene_uniquename":"YKL196C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00899","reference_uniquename":"PMID:29761456"}],"product":"Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within Golgi, endocytic trafficking to vacuole, and vacuolar fusion; membrane localization due to prenylation at carboxy-terminus; targeted to vacuole via AP-3 pathway; human homolog YKT6 can complement yeast ykt6 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001679","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL196C"}


id: YKL197C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02619":null,"YKL197C":null},"has_protein_features":false,"name":"PEX1","ortholog_annotations":[{"gene_uniquename":"YKL197C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02619","reference_uniquename":"PMID:29761456"}],"product":"AAA-peroxin; heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis; mutations in human PEX1 can lead to severe peroxisomal disorders and early death","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001680","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL197C"}


id: YKL198C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04469":null,"YKL198C":null},"has_protein_features":false,"name":"PTK1","ortholog_annotations":[{"gene_uniquename":"YKL198C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04469","reference_uniquename":"PMID:29761456"}],"product":"Putative serine/threonine protein kinase; regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein; PTK1 has a paralog, PTK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001681","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL198C"}


id: YKL199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YKL199C was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YKL198C","secondary_identifier":"SGD:S000001682","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL199C"}


id: YKL200C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YKL200C was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YKL201C","secondary_identifier":"SGD:S000001683","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL200C"}


id: YKL201C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MNN4","product":"Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; may also function as a mannosylphosphate transferase; expression increases in late-logarithmic and stationary growth phases; coding sequence contains length polymorphisms in different strains; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL201C"}


id: YKL202W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001685","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL202W"}


id: YKL203C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02723":null,"SJAG_03067":null,"YKL203C":null},"has_protein_features":false,"name":"TOR2","ortholog_annotations":[{"gene_uniquename":"YKL203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02723","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03067","reference_uniquename":"PMID:29761456"}],"product":"PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates plasma membrane (PM) homeostasis and cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; PM retention is dependent on Avo3p; malonyl-CoA is a direct ATP-competitive inhibitor of TORC1; TOR2 has a paralog, TOR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001686","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL203C"}


id: YKL204W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04291":null,"YKL204W":null},"has_protein_features":false,"name":"EAP1","ortholog_annotations":[{"gene_uniquename":"YKL204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04291","reference_uniquename":"PMID:29761456"}],"product":"eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001687","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL204W"}


id: YKL205W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02661":null,"YKL205W":null},"has_protein_features":false,"name":"LOS1","ortholog_annotations":[{"gene_uniquename":"YKL205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02661","reference_uniquename":"PMID:29761456"}],"product":"Nuclear pore protein; involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm; deletion mutation extends replicative lifespan, as does exclusion of Los1p from the nucleus in response to caloric restriction","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001688","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL205W"}


id: YKL206C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ADD66","product":"Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly","secondary_identifier":"SGD:S000001689","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL206C"}


id: YKL207W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01127":null,"YKL207W":null},"has_protein_features":false,"name":"EMC3","ortholog_annotations":[{"gene_uniquename":"YKL207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01127","reference_uniquename":"PMID:29761456"}],"product":"Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001690","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL207W"}


id: YKL208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CBT1","product":"Protein involved in 5' RNA end processing; substrates include mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p","secondary_identifier":"SGD:S000001691","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL208W"}


id: YKL209C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02602":null,"SJAG_03363":null,"YKL209C":null},"has_protein_features":false,"name":"STE6","ortholog_annotations":[{"gene_uniquename":"YKL209C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02602","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL209C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03363","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane ATP-binding cassette (ABC) transporter; required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells; human homolog ABCB1 mediates multidrug resistance in many chemotherapy-resistant tumors by effluxing toxic compounds from the cell","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001692","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL209C"}


id: YKL210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00853":null,"YKL210W":null},"has_protein_features":false,"name":"UBA1","ortholog_annotations":[{"gene_uniquename":"YKL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00853","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001693","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL210W"}


id: YKL211C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01455":null,"YKL211C":null},"has_protein_features":false,"name":"TRP3","ortholog_annotations":[{"gene_uniquename":"YKL211C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01455","reference_uniquename":"PMID:29761456"}],"product":"Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001694","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL211C"}


id: YKL212W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00880":null,"SJAG_02706":null,"YKL212W":null},"has_protein_features":false,"name":"SAC1","ortholog_annotations":[{"gene_uniquename":"YKL212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00880","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKL212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02706","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol phosphate phosphatase; role in early and medial Golgi PtdIns4P hydrolysis; regulated by Vps74p interaction; ER localized transmembrane protein which cycles through the Golgi; role in protein trafficking, processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis by modulating PtdIns(4)P metabolism; PtdIns4P PPase activity is crucial for autophagosome-vacuole fusion during autophagy; human homolog SACM1L complements autophagy defects of the null","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001695","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL212W"}


id: YKL213C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00312":null,"YKL213C":null},"has_protein_features":false,"name":"DOA1","ortholog_annotations":[{"gene_uniquename":"YKL213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00312","reference_uniquename":"PMID:29761456"}],"product":"WD-repeat protein involved in Ub-mediated proteolysis; K48-, K29-specific Ub chain binding protein involved in Ub homeostasis; substrate-recruiting adaptor for Cdc48p in mitochondria-associated degradation; inhibits degradation of Ufd2p-dependent substrates; facilitates proteolysis of Cse4p, a centromeric H3-like protein; required for ribophagy; promotes NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001696","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL213C"}


id: YKL214C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YRA2","product":"Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus","secondary_identifier":"SGD:S000001697","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL214C"}


id: YKL215C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01995":null,"YKL215C":null},"has_protein_features":false,"name":"OXP1","ortholog_annotations":[{"gene_uniquename":"YKL215C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01995","reference_uniquename":"PMID:29761456"}],"product":"5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001698","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL215C"}


id: YKL216W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00197":null,"YKL216W":null},"has_protein_features":false,"name":"URA1","ortholog_annotations":[{"gene_uniquename":"YKL216W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00197","reference_uniquename":"PMID:29761456"}],"product":"Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001699","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL216W"}


id: YKL217W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"JEN1","product":"Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose","secondary_identifier":"SGD:S000001700","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL217W"}


id: YKL218C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SRY1","product":"3-hydroxyaspartate dehydratase; deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity","secondary_identifier":"SGD:S000001701","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL218C"}


id: YKL219W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS9","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000001702","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL219W"}


id: YKL220C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04743":null,"YKL220C":null},"has_protein_features":false,"name":"FRE2","ortholog_annotations":[{"gene_uniquename":"YKL220C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001703","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL220C"}


id: YKL221W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MCH2","product":"Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport","secondary_identifier":"SGD:S000001704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL221W"}


id: YKL222C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine","secondary_identifier":"SGD:S000001705","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL222C"}


id: YKL223W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001706","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL223W"}


id: YKL224C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU16","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole","secondary_identifier":"SGD:S000001707","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL224C"}


id: YKL225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001708","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKL225W"}


id: YKR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02384":null,"YKR001C":null},"has_protein_features":false,"name":"VPS1","ortholog_annotations":[{"gene_uniquename":"YKR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02384","reference_uniquename":"PMID:29761456"}],"product":"Dynamin-like GTPase required for vacuolar sorting; promotes fission of retrograde transport carriers from endosome; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001709","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR001C"}


id: YKR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02720":null,"YKR002W":null},"has_protein_features":false,"name":"PAP1","ortholog_annotations":[{"gene_uniquename":"YKR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02720","reference_uniquename":"PMID:29761456"}],"product":"Poly(A) polymerase; one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001710","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR002W"}


id: YKR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01590":null,"SJAG_02323":null,"SJAG_02375":null,"SJAG_03718":null,"YKR003W":null},"has_protein_features":false,"name":"OSH6","ortholog_annotations":[{"gene_uniquename":"YKR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01590","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02323","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02375","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03718","reference_uniquename":"PMID:29761456"}],"product":"Oxysterol-binding  phosphatidylserine transferase; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion; OSH6 has a paralog, OSH7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001711","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR003W"}


id: YKR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM9","product":"Non-essential protein of unknown function","secondary_identifier":"SGD:S000001712","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR004C"}


id: YKR004C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discreet protein; YKR004C-A was originally annotated as an independent ORF, but was later demonstrated to be an exon of an adjacent ORF, YKR004C","secondary_identifier":"SGD:S000028559","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR004C-A"}


id: YKR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001713","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR005C"}


id: YKR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRPL13","product":"Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation","secondary_identifier":"SGD:S000001714","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR006C"}


id: YKR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03928":null,"YKR007W":null},"has_protein_features":false,"name":"MEH1","ortholog_annotations":[{"gene_uniquename":"YKR007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03928","reference_uniquename":"PMID:29761456"}],"product":"Subunit of EGO/GSE complex; vacuolar/endosomal membrane-associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from endosome to plasma membrane; targeted to vacuole via AP-3 pathway; loss results in defect in vacuolar acidification","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001715","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR007W"}


id: YKR008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00440":null,"YKR008W":null},"has_protein_features":false,"name":"RSC4","ortholog_annotations":[{"gene_uniquename":"YKR008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00440","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001716","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR008W"}


id: YKR009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FOX2","product":"3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase; multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; mutation is functionally complemented by human HSD17B4","secondary_identifier":"SGD:S000001717","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR009C"}


id: YKR010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00883":null,"YKR010C":null},"has_protein_features":false,"name":"TOF2","ortholog_annotations":[{"gene_uniquename":"YKR010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00883","reference_uniquename":"PMID:29761456"}],"product":"Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001718","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR010C"}


id: YKR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FPT1","product":"Chromatin-associated negative regulator of RNA polymerase III assembly; differentially and dynamically occupies RNA polymerase III-transcribed genes; promotes eviction of RNAPIII; occupancy depends on TFIIIB and TFIIIC, not RNAPIII; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000001719","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR011C"}


id: YKR012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2","secondary_identifier":"SGD:S000001720","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR012C"}


id: YKR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRY2","product":"Sterol binding protein involved in the export of acetylated sterols; role in sterol export is redundant with that of PRY1; redundant role with PRY1 and PRY3 in the export of free fatty acids; may be involved in detoxification of hydrophobic compounds; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins)","secondary_identifier":"SGD:S000001721","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR013W"}


id: YKR014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01379":null,"YKR014C":null},"has_protein_features":false,"name":"YPT52","ortholog_annotations":[{"gene_uniquename":"YKR014C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01379","reference_uniquename":"PMID:29761456"}],"product":"Endosomal Rab family GTPase; required for vacuolar protein sorting, endocytosis and multivesicular body (MVB) biogenesis and sorting; required for localization of the CORVET complex to endosomes; involved in autophagy and ionic stress tolerance; similar to Vps21p and Ypt53p; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001722","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR014C"}


id: YKR015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001723","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR015C"}


id: YKR016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02028":null,"YKR016W":null},"has_protein_features":false,"name":"MIC60","ortholog_annotations":[{"gene_uniquename":"YKR016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02028","reference_uniquename":"PMID:29761456"}],"product":"Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic60p is also involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; ortholog of mammalian mitofilin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR016W"}


id: YKR017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01533":null,"YKR017C":null},"has_protein_features":false,"name":"HEL1","ortholog_annotations":[{"gene_uniquename":"YKR017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01533","reference_uniquename":"PMID:29761456"}],"product":"RING finger ubiquitin ligase (E3); involved in ubiquitination and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001725","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR017C"}


id: YKR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00219":null,"SJAG_00270":null,"YKR018C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YKR018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00219","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00270","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001726","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR018C"}


id: YKR019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00724":null,"YKR019C":null},"has_protein_features":false,"name":"IRS4","ortholog_annotations":[{"gene_uniquename":"YKR019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00724","reference_uniquename":"PMID:29761456"}],"product":"EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001727","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR019C"}


id: YKR020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01645":null,"YKR020W":null},"has_protein_features":false,"name":"VPS51","ortholog_annotations":[{"gene_uniquename":"YKR020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01645","reference_uniquename":"PMID:29761456"}],"product":"Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; links the (VFT/GARP) complex to the SNARE Tlg1p; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001728","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR020W"}


id: YKR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00032":null,"SJAG_03643":null,"YKR021W":null},"has_protein_features":false,"name":"ALY1","ortholog_annotations":[{"gene_uniquename":"YKR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00032","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03643","reference_uniquename":"PMID:29761456"}],"product":"Alpha arrestin, substrate of calcineurin; controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; dephosphorylation of Aly1p required for the endocytosis of Dip5p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; regulates intracellular pH; ALY1 has a paralog, ALY2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001729","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR021W"}


id: YKR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00206":null,"YKR022C":null},"has_protein_features":false,"name":"NTR2","ortholog_annotations":[{"gene_uniquename":"YKR022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00206","reference_uniquename":"PMID:29761456"}],"product":"Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001730","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR022C"}


id: YKR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02096":null,"YKR023W":null},"has_protein_features":false,"name":"RQT4","ortholog_annotations":[{"gene_uniquename":"YKR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02096","reference_uniquename":"PMID:29761456"}],"product":"Subunit of ribosome-associated quality control trigger complex (RQT); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001731","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR023W"}


id: YKR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00583":null,"YKR024C":null},"has_protein_features":false,"name":"DBP7","ortholog_annotations":[{"gene_uniquename":"YKR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00583","reference_uniquename":"PMID:29761456"}],"product":"Putative ATP-dependent RNA helicase of the DEAD-box family; involved in ribosomal biogenesis; required at post-transcriptional step for efficient retrotransposition; essential for growth under anaerobic conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001732","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR024C"}


id: YKR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03921":null,"YKR025W":null},"has_protein_features":false,"name":"RPC37","ortholog_annotations":[{"gene_uniquename":"YKR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03921","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase III subunit C37","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001733","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR025W"}


id: YKR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03678":null,"YKR026C":null},"has_protein_features":false,"name":"GCN3","ortholog_annotations":[{"gene_uniquename":"YKR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03678","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of translation initiation factor eIF2B (eIF2Bα); guanine-nucleotide exchange factor for eIF2; mutations in eIF2Bα alter localization of eIF2B; activity regulated by phosphorylated eIF2; positive regulator of GCN4 expression; mutations in human ortholog EIF2B2 cause fatal brain disease childhood ataxia with central nervous system hypomyelination (CACH); human ortholog EIF2B1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001734","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR026C"}


id: YKR027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00916":null,"YKR027W":null},"has_protein_features":false,"name":"BCH2","ortholog_annotations":[{"gene_uniquename":"YKR027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00916","reference_uniquename":"PMID:29761456"}],"product":"Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001735","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR027W"}


id: YKR028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04638":null,"YKR028W":null},"has_protein_features":false,"name":"SAP190","ortholog_annotations":[{"gene_uniquename":"YKR028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04638","reference_uniquename":"PMID:29761456"}],"product":"Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001736","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR028W"}


id: YKR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04396":null,"YKR029C":null},"has_protein_features":false,"name":"SET3","ortholog_annotations":[{"gene_uniquename":"YKR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04396","reference_uniquename":"PMID:29761456"}],"product":"Defining member of the SET3 histone deacetylase complex; which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001737","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR029C"}


id: YKR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02910":null,"YKR030W":null},"has_protein_features":false,"name":"GMH1","ortholog_annotations":[{"gene_uniquename":"YKR030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02910","reference_uniquename":"PMID:29761456"}],"product":"Golgi membrane protein of unknown function; interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting; conserved from yeast to human","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001738","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR030W"}


id: YKR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01519":null,"YKR031C":null},"has_protein_features":false,"name":"SPO14","ortholog_annotations":[{"gene_uniquename":"YKR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01519","reference_uniquename":"PMID:29761456"}],"product":"Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with 'foot domain' of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001739","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR031C"}


id: YKR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000001740","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR032W"}


id: YKR033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80","secondary_identifier":"SGD:S000001741","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR033C"}


id: YKR034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00792":null,"YKR034W":null},"has_protein_features":false,"name":"DAL80","ortholog_annotations":[{"gene_uniquename":"YKR034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00792","reference_uniquename":"PMID:29761456"}],"product":"Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001742","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR034W"}


id: YKR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OPI8","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A","secondary_identifier":"SGD:S000001743","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR035C"}


id: YKR035W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00900":null,"YKR035W-A":null},"has_protein_features":false,"name":"DID2","ortholog_annotations":[{"gene_uniquename":"YKR035W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00900","reference_uniquename":"PMID:29761456"}],"product":"Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR035W-A"}


id: YKR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04732":null,"YKR036C":null},"has_protein_features":false,"name":"CAF4","ortholog_annotations":[{"gene_uniquename":"YKR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04732","reference_uniquename":"PMID:26896847"}],"product":"WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001744","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR036C"}


id: YKR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05266":null,"YKR037C":null},"has_protein_features":false,"name":"SPC34","ortholog_annotations":[{"gene_uniquename":"YKR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05266","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001745","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR037C"}


id: YKR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04182":null,"YKR038C":null},"has_protein_features":false,"name":"KAE1","ortholog_annotations":[{"gene_uniquename":"YKR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04182","reference_uniquename":"PMID:29761456"}],"product":"ADP/GDP nucleotidase, essential functional component of KEOPS complex, with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; homolog of human OSGEP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001746","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR038C"}


id: YKR039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YKR039W":null},"has_protein_features":false,"name":"GAP1","ortholog_annotations":[{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"General amino acid permease; involved in uptake of all L-amino acids, some D-amino acids, related compounds, toxic analogs and polyamines; regulated by nitrogen source; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; essential for invasive growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001747","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR039W"}


id: YKR040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W","secondary_identifier":"SGD:S000001748","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR040C"}


id: YKR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking","secondary_identifier":"SGD:S000001749","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR041W"}


id: YKR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02649":null,"SJAG_03295":null,"YKR042W":null},"has_protein_features":false,"name":"UTH1","ortholog_annotations":[{"gene_uniquename":"YKR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02649","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03295","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein; role in mitophagy is disputed; implicated in cell wall biogenesis, the oxidative stress response, life span during starvation, and cell death; SUN family member; UTH1 has a paralog, NCA3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001750","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR042W"}


id: YKR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SHB17","product":"Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus","secondary_identifier":"SGD:S000001751","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR043C"}


id: YKR044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01991":null,"YKR044W":null},"has_protein_features":false,"name":"UIP5","ortholog_annotations":[{"gene_uniquename":"YKR044W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01991","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function that interacts with Ulp1p; a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001752","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR044W"}


id: YKR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm","secondary_identifier":"SGD:S000001753","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR045C"}


id: YKR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PLN1","product":"Perilipin, involved in formation and stability of lipid droplets; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange","secondary_identifier":"SGD:S000001754","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR046C"}


id: YKR047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1","secondary_identifier":"SGD:S000001755","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR047W"}


id: YKR048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00942":null,"SJAG_02314":null,"YKR048C":null},"has_protein_features":false,"name":"NAP1","ortholog_annotations":[{"gene_uniquename":"YKR048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00942","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02314","reference_uniquename":"PMID:29761456"}],"product":"Histone chaperone and assembly chaperone for Rps6a/b; involved in histone exchange, replacing histone H2A-H2B dimers or histone variant dimers from assembled nucleosomes; promotes solubility of Rps6a, and 40S ribosomal subunit biogenesis; role in transport of H2A and H2B histones to the nucleus; regulates microtubule dynamics during mitosis; interacts with mitotic cyclin Clb2p; controls bud morphogenesis; phosphorylated by CK2; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001756","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR048C"}


id: YKR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMP46","product":"Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000001757","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR049C"}


id: YKR050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01353":null,"SJAG_02883":null,"YKR050W":null},"has_protein_features":false,"name":"TRK2","ortholog_annotations":[{"gene_uniquename":"YKR050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01353","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02883","reference_uniquename":"PMID:29761456"}],"product":"Component of the Trk1p-Trk2p potassium transport system; contributes to K(+) supply and maintenance of plasma-membrane potential; TRK2 has a paralog, TRK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001758","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR050W"}


id: YKR051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03725":null,"YKR051W":null},"has_protein_features":false,"name":"HFL1","ortholog_annotations":[{"gene_uniquename":"YKR051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03725","reference_uniquename":"PMID:29761456"}],"product":"Vacuole membrane protein that interacts with Atg8p; functions in the vacuolar membrane recruitment of Atg8p to facilitate the degradation of vacuolar integral membrane proteins during early-stationary vacuole turnover (EVT), a general degradation process for vacuolar integral membrane proteins when cells enter stationary phase; null mutant is defective in stationary phase-induced vacuolar microdomain formation; homolog of S. pombe hfl1; homolog of human TMEM184","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001759","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR051W"}


id: YKR052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02473":null,"SJAG_04737":null,"YKR052C":null},"has_protein_features":false,"name":"MRS4","ortholog_annotations":[{"gene_uniquename":"YKR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02473","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04737","reference_uniquename":"PMID:29761456"}],"product":"Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001760","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR052C"}


id: YKR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04986":null,"YKR053C":null},"has_protein_features":false,"name":"YSR3","ortholog_annotations":[{"gene_uniquename":"YKR053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04986","reference_uniquename":"PMID:29761456"}],"product":"Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001761","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR053C"}


id: YKR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02286":null,"YKR054C":null},"has_protein_features":false,"name":"DYN1","ortholog_annotations":[{"gene_uniquename":"YKR054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02286","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001762","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR054C"}


id: YKR055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01774":null,"YKR055W":null},"has_protein_features":false,"name":"RHO4","ortholog_annotations":[{"gene_uniquename":"YKR055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01774","reference_uniquename":"PMID:29761456"}],"product":"Non-essential small GTPase; member of the Rho/Rac subfamily of Ras-like proteins; likely to be involved in the establishment of cell polarity; has long N-terminal extension that plays an important role in Rho4p function and is shared with Rho4 homologs in other yeasts and filamentous fungi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001763","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR055W"}


id: YKR056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04736":null,"YKR056W":null},"has_protein_features":false,"name":"TRM2","ortholog_annotations":[{"gene_uniquename":"YKR056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04736","reference_uniquename":"PMID:29761456"}],"product":"tRNA methyltransferase; 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; involved in the methylation of guanosine and uridine ribonucleosides in mRNA; endo-exonuclease with a role in DNA repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001764","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR056W"}


id: YKR057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04174":null,"YKR057W":null},"has_protein_features":false,"name":"RPS21A","ortholog_annotations":[{"gene_uniquename":"YKR057W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04174","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001765","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR057W"}


id: YKR058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GLG1","product":"Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole respectively; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001766","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR058W"}


id: YKR059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04772":null,"YKR059W":null},"has_protein_features":false,"name":"TIF1","ortholog_annotations":[{"gene_uniquename":"YKR059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04772","reference_uniquename":"PMID:29761456"}],"product":"Translation initiation factor eIF4A; DEAD-box RNA helicase that couples ATPase activity to mRNA binding and unwinding; ATP hydrolysis accelerates the recruitment of mRNA during 48S preinitiation complex (PIC) assembly; ATPase activity stimulated by either eIF4G1 or by the PIC in an eIF3g and eIFGi subunit-dependent manner, independent of eIF4E and eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E and eIF4G; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001767","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR059W"}


id: YKR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01420":null,"SJAG_01752":null,"YKR060W":null},"has_protein_features":false,"name":"UTP30","ortholog_annotations":[{"gene_uniquename":"YKR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01420","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01752","reference_uniquename":"PMID:29761456"}],"product":"Subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit; Utp30p is peripherally associated with 90S preribosome and appears partially redundant with its paralog Cic1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001768","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR060W"}


id: YKR061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"YKR061W":null},"has_protein_features":false,"name":"KTR2","ortholog_annotations":[{"gene_uniquename":"YKR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"}],"product":"Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001769","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR061W"}


id: YKR062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00159":null,"YKR062W":null},"has_protein_features":false,"name":"TFA2","ortholog_annotations":[{"gene_uniquename":"YKR062W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00159","reference_uniquename":"PMID:29761456"}],"product":"TFIIE small subunit; involved in RNA polymerase II transcription initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001770","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR062W"}


id: YKR063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01581":null,"YKR063C":null},"has_protein_features":false,"name":"LAS1","ortholog_annotations":[{"gene_uniquename":"YKR063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01581","reference_uniquename":"PMID:29761456"}],"product":"Endonuclease involved in pre-rRNA processing at both ends of ITS2; functions with Grc3p in a conserved mechanism to cleave pre-rRNA at a specific site during rRNA processing and ribosome biogenesis; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S cell cycle transition; human ortholog is Las1L; mutants require the SSD1-v allele for viability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001771","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR063C"}


id: YKR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OAF3","product":"Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress","secondary_identifier":"SGD:S000001772","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR064W"}


id: YKR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04432":null,"YKR065C":null},"has_protein_features":false,"name":"PAM17","ortholog_annotations":[{"gene_uniquename":"YKR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04432","reference_uniquename":"PMID:29761456"}],"product":"Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001773","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR065C"}


id: YKR066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CCP1","product":"Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria; acts as hydrogen peroxide sensor in mitochondria, involved in the response to oxidative stress","secondary_identifier":"SGD:S000001774","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR066C"}


id: YKR067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02654":null,"SJAG_03305":null,"YKR067W":null},"has_protein_features":false,"name":"GPT2","ortholog_annotations":[{"gene_uniquename":"YKR067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02654","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03305","reference_uniquename":"PMID:26896847"}],"product":"Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001775","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR067W"}


id: YKR068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01415":null,"YKR068C":null},"has_protein_features":false,"name":"BET3","ortholog_annotations":[{"gene_uniquename":"YKR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01415","reference_uniquename":"PMID:29761456"}],"product":"Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); hydrophilic homodimeric protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001776","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR068C"}


id: YKR069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01192":null,"YKR069W":null},"has_protein_features":false,"name":"MET1","ortholog_annotations":[{"gene_uniquename":"YKR069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01192","reference_uniquename":"PMID:29761456"}],"product":"S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001777","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR069W"}


id: YKR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04317":null,"YKR070W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YKR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04317","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001778","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR070W"}


id: YKR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00455":null,"YKR071C":null},"has_protein_features":false,"name":"DRE2","ortholog_annotations":[{"gene_uniquename":"YKR071C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00455","reference_uniquename":"PMID:29761456"}],"product":"Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18p in an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress; inviability of the null mutant is functionally complemented by human CIAPIN1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001779","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR071C"}


id: YKR072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SIS2","product":"Negative regulatory subunit of protein phosphatase 1 (Ppz1p); involved in coenzyme A biosynthesis; subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC: Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p); dose-dependent regulator of replicative lifespan; SIS2 has a paralog, VHS3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001780","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR072C"}


id: YKR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000001781","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR073C"}


id: YKR074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04741":null,"YKR074W":null},"has_protein_features":false,"name":"AIM29","ortholog_annotations":[{"gene_uniquename":"YKR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04741","reference_uniquename":"PMID:29761456"}],"product":"Zpr1p co-chaperone; recognizes eEF1A in GTP-bound, pre-hydrolysis conformation, dampens folding complex GTPase activity to drive client release from Zpr1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001782","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR074W"}


id: YKR075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; similar to Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; YKR075C has a paralog, YOR062C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001783","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR075C"}


id: YKR075W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a protein; completely overlaps the uncharacterized gene YKR075C; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR075W-A"}


id: YKR076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM4","product":"S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR); glutathione transferase involved in cell-surface biosynthesis and architecture; catalyzes glutathione (GSH)-dependent reduction of GS-trichloro-p-hydroquinone to trichloro-p-hydroquinone; expression upregulated upon exposure to genotoxic agents, such as methyl methanesulfonate, cisplatin and bleomycin; not an essential gene; similar to YGR154C; green fluorescent protein (GFP)-fusion protein localizes to cytoplasm","secondary_identifier":"SGD:S000001784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR076W"}


id: YKR077W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MSA2","product":"Putative transcriptional activator; interacts with G1-specific transcription factor MBF and G1-specific promoters; MSA2 has a paralog, MSA1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001785","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR077W"}


id: YKR078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VPS501","product":"Vacuolar SNX-BAR protein, regulates TORC1 signaling during autophagy induction; binds phosphatidylinositol-3-phosphate; vacuolar localization of Vps501p is dependent upon direct interaction with Iml1p and a unique lipid binding specificity that is also required for its function; VPS501 has paralog VPS5 that arose from the whole genome duplication","secondary_identifier":"SGD:S000001786","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR078W"}


id: YKR079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00997":null,"SJAG_04885":null,"YKR079C":null},"has_protein_features":false,"name":"TRZ1","ortholog_annotations":[{"gene_uniquename":"YKR079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00997","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04885","reference_uniquename":"PMID:29761456"}],"product":"tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001787","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR079C"}


id: YKR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01126":null,"YKR080W":null},"has_protein_features":false,"name":"MTD1","ortholog_annotations":[{"gene_uniquename":"YKR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01126","reference_uniquename":"PMID:29761456"}],"product":"NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase; plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001788","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR080W"}


id: YKR081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04108":null,"YKR081C":null},"has_protein_features":false,"name":"RPF2","ortholog_annotations":[{"gene_uniquename":"YKR081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04108","reference_uniquename":"PMID:29761456"}],"product":"Essential protein involved in rRNA maturation and ribosomal assembly; involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001789","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR081C"}


id: YKR082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01374":null,"SJAG_03986":null,"YKR082W":null},"has_protein_features":false,"name":"NUP133","ortholog_annotations":[{"gene_uniquename":"YKR082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01374","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03986","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Nup84p subcomplex of nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis; is involved in establishment of a normal nucleocytoplasmic concentration gradient of GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at nuclear periphery, including double-strand break repair, transcription and chromatin silencing; relocalizes to cytosol in response to hypoxia; homolog of human NUP133","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001790","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR082W"}


id: YKR083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01371":null,"YKR083C":null},"has_protein_features":false,"name":"DAD2","ortholog_annotations":[{"gene_uniquename":"YKR083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01371","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001791","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR083C"}


id: YKR084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02601":null,"YKR084C":null},"has_protein_features":false,"name":"HBS1","ortholog_annotations":[{"gene_uniquename":"YKR084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02601","reference_uniquename":"PMID:29761456"}],"product":"GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, particularly in 3' UTRs; genetically implicated in mRNA no-go decay; HBS1 has a paralog, SKI7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001792","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR084C"}


id: YKR085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04244":null,"YKR085C":null},"has_protein_features":false,"name":"MRPL20","ortholog_annotations":[{"gene_uniquename":"YKR085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04244","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001793","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR085C"}


id: YKR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01152":null,"YKR086W":null},"has_protein_features":false,"name":"PRP16","ortholog_annotations":[{"gene_uniquename":"YKR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01152","reference_uniquename":"PMID:29761456"}],"product":"DEAH-box RNA helicase; involved in the second catalytic step of splicing and in exon ligation; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step; missense mutation in human ortholog DHX38 associated with early-onset retinitis pigmentosa","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001794","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR086W"}


id: YKR087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04514":null,"YKR087C":null},"has_protein_features":false,"name":"OMA1","ortholog_annotations":[{"gene_uniquename":"YKR087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04514","reference_uniquename":"PMID:29761456"}],"product":"Metalloendopeptidase of the mitochondrial inner membrane; important for adaptive responses to various homeostatic insults, preservation of normal mitochondrial function under damage-eliciting conditions, and stability of respiratory supercomplexes; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; zebrafish ortholog has a role in organ development and mouse ortholog is also required for respiratory supercomplex stability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001795","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR087C"}


id: YKR088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01133":null,"YKR088C":null},"has_protein_features":false,"name":"TVP38","ortholog_annotations":[{"gene_uniquename":"YKR088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01133","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001796","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR088C"}


id: YKR089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02089":null,"SJAG_02907":null,"YKR089C":null},"has_protein_features":false,"name":"TGL4","ortholog_annotations":[{"gene_uniquename":"YKR089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02089","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02907","reference_uniquename":"PMID:29761456"}],"product":"Multifunctional lipase/hydrolase/phospholipase; triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p; TGL4 has a paralog, TGL5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001797","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR089C"}


id: YKR090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02831":null,"YKR090W":null},"has_protein_features":false,"name":"PXL1","ortholog_annotations":[{"gene_uniquename":"YKR090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02831","reference_uniquename":"PMID:29761456"}],"product":"Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001798","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR090W"}


id: YKR091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SRL3","product":"Transcriptional repressor at START; binds to SBF (Swi4p-Swi6p) at SCB promoter elements in G1 to repress transcription; START inhibitor that retains Cdc28-Cln3 at the ER; acts with Ydj1p to promote release of the complex in a growth-mediated positive feedback loop to trigger START; unstable and degraded by SCF-Grr1 after phosphorylation; contains a G1/S transcription factor binding (GTB) motif; binds SBF-regulated promoters in HU-treated cells; substrate of Cdc28p and Pho85p; hyperphosphorylated","secondary_identifier":"SGD:S000001799","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR091W"}


id: YKR092C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01125":null,"YKR092C":null},"has_protein_features":false,"name":"SRP40","ortholog_annotations":[{"gene_uniquename":"YKR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01125","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar serine-rich protein; role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001800","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR092C"}


id: YKR093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01983":null,"YKR093W":null},"has_protein_features":false,"name":"PTR2","ortholog_annotations":[{"gene_uniquename":"YKR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01983","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by N-end rule pathway via repression by Cup9p; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001801","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR093W"}


id: YKR094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01365":null,"SJAG_02891":null,"SJAG_03971":null,"YKR094C":null},"has_protein_features":false,"name":"RPL40B","ortholog_annotations":[{"gene_uniquename":"YKR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01365","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02891","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03971","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001802","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR094C"}


id: YKR095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03300":null,"SJAG_04645":null,"YKR095W":null},"has_protein_features":false,"name":"MLP1","ortholog_annotations":[{"gene_uniquename":"YKR095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03300","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YKR095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04645","reference_uniquename":"PMID:29761456"}],"product":"Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs; MLP1 has a paralog, MLP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001803","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR095W"}


id: YKR095W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02863":null,"YKR095W-A":null},"has_protein_features":false,"name":"PCC1","ortholog_annotations":[{"gene_uniquename":"YKR095W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02863","reference_uniquename":"PMID:29761456"}],"product":"Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; other complex members are Kae1p, Gon7p, Bud32p, and Cgi121p; ortholog of human LAGE3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028512","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR095W-A"}


id: YKR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01720":null,"YKR096W":null},"has_protein_features":false,"name":"ESL2","ortholog_annotations":[{"gene_uniquename":"YKR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01720","reference_uniquename":"PMID:29761456"}],"product":"hEST1A/B (SMG5/6)-like protein; contributes to environment-sensing adaptive gene expression responses; Esl2p and Esl1p contain a 14-3-3-like domain and a putative PilT N-terminus ribonuclease domain; interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; ESL2 has a paralog, ESL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001804","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR096W"}


id: YKR097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PCK1","product":"Phosphoenolpyruvate carboxykinase; key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol","secondary_identifier":"SGD:S000001805","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR097W"}


id: YKR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UBP11","product":"Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; UBP11 has a paralog, UBP7, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR098C"}


id: YKR099C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a protein; YKR099C-A was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YKR100C","secondary_identifier":"SGD:S000028842","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR099C-A"}


id: YKR099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BAS1","product":"Myb-related transcription factor; involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; controls cellular ATP levels; also involved in regulation of meiotic recombination at specific genes","secondary_identifier":"SGD:S000001807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR099W"}


id: YKR100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SKG1","product":"Transmembrane protein with a role in cell wall polymer composition; localizes on inner surface of plasma membrane at bud and in daughter cell; SKG1 has a paralog, AIM20, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR100C"}


id: YKR101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SIR1","product":"Protein involved in silencing at mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin","secondary_identifier":"SGD:S000001809","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR101W"}


id: YKR102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FLO10","product":"Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth","secondary_identifier":"SGD:S000001810","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR102W"}


id: YKR103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NFT1","product":"Putative transporter of the MRP subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; MRP stands for multidrug resistance-associated protein","secondary_identifier":"SGD:S000001811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR103W"}


id: YKR104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative transporter of the MRP subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; MRP stands for multidrug resistance-associated protein","secondary_identifier":"SGD:S000001812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR104W"}


id: YKR105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01336":null,"SJAG_01636":null,"SJAG_01923":null,"SJAG_04983":null,"YKR105C":null},"has_protein_features":false,"name":"VBA5","ortholog_annotations":[{"gene_uniquename":"YKR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01336","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01636","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01923","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04983","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; VBA5 has a paralog, VBA3, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001813","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR105C"}


id: YKR106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YKR106W":null},"has_protein_features":false,"name":"GEX2","ortholog_annotations":[{"gene_uniquename":"YKR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; expressed at a very low level; potential role in resistance to oxidative stress and modulation of the PKA pathway; GEX2 has a paralog, GEX1, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001814","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR106W"}


id: YLL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02848":null,"YLL001W":null},"has_protein_features":false,"name":"DNM1","ortholog_annotations":[{"gene_uniquename":"YLL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02848","reference_uniquename":"PMID:29761456"}],"product":"Dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and inheritance; self assembles on the cytoplasmic face of mitochondrial tubules at sites where division will occur; participates in endocytosis and regulates peroxisome fission along with Vps1p; mutants in the human ortholog DNM1L, which mediates mitochondrial fission, peroxisomal division, autophagy, and mitophagy, are associated with slowly progressive infantile encephalopathy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003924","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL001W"}


id: YLL002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01204":null,"YLL002W":null},"has_protein_features":false,"name":"RTT109","ortholog_annotations":[{"gene_uniquename":"YLL002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01204","reference_uniquename":"PMID:29761456"}],"product":"Histone acetyltransferase; critical for cell survival in presence of DNA damage during S phase, required for recovery after DSB repair; acetylates H3K56, H3K9; H3K56 acetylation activity required for expression homeostasis, buffering of mRNA synthesis rate against changes in gene dosage during S phase; involved in non-homologous end joining and regulation of Ty1 transposition; prevents hyper-amplification of rDNA; interacts physically with Vps75p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003925","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL002W"}


id: YLL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03544":null,"YLL003W":null},"has_protein_features":false,"name":"SFI1","ortholog_annotations":[{"gene_uniquename":"YLL003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03544","reference_uniquename":"PMID:29761456"}],"product":"Centrin (Cdc31p)-binding protein required for SPB duplication; localizes to the half-bridge of the spindle pole body (SPB); required for progression through G(2)-M transition; phosphorylated by Cdc28p-Clb2p and by Cdc5p; dephosphorylated by Cdc14p; has similarity to Xenopus laevis XCAP-C","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003926","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL003W"}


id: YLL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05301":null,"YLL004W":null},"has_protein_features":false,"name":"ORC3","ortholog_annotations":[{"gene_uniquename":"YLL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05301","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003927","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL004W"}


id: YLL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPO75","product":"Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis","secondary_identifier":"SGD:S000003928","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL005C"}


id: YLL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04370":null,"YLL006W":null},"has_protein_features":false,"name":"MMM1","ortholog_annotations":[{"gene_uniquename":"YLL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04370","reference_uniquename":"PMID:29761456"}],"product":"ER integral membrane protein, ERMES complex subunit; ERMES links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase; localizes to the peroxisome in glucose","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003929","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL006W"}


id: YLL006W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028560","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL006W-A"}


id: YLL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LMO1","product":"Homolog of mammalian ELMO (Engulfment and celL MOtility); upstream component for regulation through the small GTPase Rho5p; may form a complex with Dck1p that acts as a GEF for Rho5p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein","secondary_identifier":"SGD:S000003930","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL007C"}


id: YLL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03730":null,"YLL008W":null},"has_protein_features":false,"name":"DRS1","ortholog_annotations":[{"gene_uniquename":"YLL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03730","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar DEAD-box protein required for ribosome assembly and function; including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003931","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL008W"}


id: YLL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00449":null,"YLL009C":null},"has_protein_features":false,"name":"COX17","ortholog_annotations":[{"gene_uniquename":"YLL009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00449","reference_uniquename":"PMID:29761456"}],"product":"Copper metallochaperone that transfers copper to Sco1p and Cox11p; eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs; interacts with the MICOS complex, and interaction is promoted by copper ions; human homolog COX17 partially complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003932","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL009C"}


id: YLL010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02389":null,"SJAG_04128":null,"YLL010C":null},"has_protein_features":false,"name":"PSR1","ortholog_annotations":[{"gene_uniquename":"YLL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02389","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04128","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane-associated protein phosphatase; involved in the general stress response and the inactivating dephosphorylation of Mep2p; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through Msn2p dephosphorylation, and for inhibition of TORC1 in response to limiting amino acids; regulates the sodium ion stress response with Psr2p; member of the HAD family of protein phosphatases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003933","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL010C"}


id: YLL011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03569":null,"YLL011W":null},"has_protein_features":false,"name":"SOF1","ortholog_annotations":[{"gene_uniquename":"YLL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03569","reference_uniquename":"PMID:29761456"}],"product":"Protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003934","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL011W"}


id: YLL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YEH1","product":"Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes; YEH1 has a paralog, YEH2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003935","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL012W"}


id: YLL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00686":null,"SJAG_00759":null,"SJAG_02036":null,"YLL013C":null},"has_protein_features":false,"name":"PUF3","ortholog_annotations":[{"gene_uniquename":"YLL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00686","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00759","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02036","reference_uniquename":"PMID:29761456"}],"product":"Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochondria during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins; translationally represses oxidative stress-linked genes; regulates CoQ biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003936","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL013C"}


id: YLL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04294":null,"YLL014W":null},"has_protein_features":false,"name":"EMC6","ortholog_annotations":[{"gene_uniquename":"YLL014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04294","reference_uniquename":"PMID:29761456"}],"product":"Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003937","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL014W"}


id: YLL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01344":null,"SJAG_03785":null,"SJAG_05213":null,"YLL015W":null},"has_protein_features":false,"name":"BPT1","ortholog_annotations":[{"gene_uniquename":"YLL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01344","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03785","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05213","reference_uniquename":"PMID:29761456"}],"product":"ABC type transmembrane transporter of MRP/CFTR family; found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003938","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL015W"}


id: YLL018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01197":null,"YLL018C":null},"has_protein_features":false,"name":"DPS1","ortholog_annotations":[{"gene_uniquename":"YLL018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01197","reference_uniquename":"PMID:29761456"}],"product":"Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation; shares five highly conserved amino acids with human that when mutated cause leukoencephalopathy characterized by hypomyelination with brain stem and spinal cord involvement and leg spasticity (HBSL)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003941","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL018C"}


id: YLL018C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01996":null,"YLL018C-A":null},"has_protein_features":false,"name":"COX19","ortholog_annotations":[{"gene_uniquename":"YLL018C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01996","reference_uniquename":"PMID:29761456"}],"product":"Protein required for cytochrome c oxidase assembly; located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL018C-A"}


id: YLL019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00996":null,"YLL019C":null},"has_protein_features":false,"name":"KNS1","ortholog_annotations":[{"gene_uniquename":"YLL019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00996","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003942","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL019C"}


id: YLL019W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene KNS1","secondary_identifier":"SGD:S000028670","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL019W-A"}


id: YLL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1","secondary_identifier":"SGD:S000003943","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL020C"}


id: YLL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03625":null,"YLL021W":null},"has_protein_features":false,"name":"SPA2","ortholog_annotations":[{"gene_uniquename":"YLL021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03625","reference_uniquename":"PMID:29761456"}],"product":"Component of the polarisome; functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate; coding sequence contains length polymorphisms in different strains; SPA2 has a paralog, SPH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003944","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL021W"}


id: YLL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04547":null,"YLL022C":null},"has_protein_features":false,"name":"HIF1","ortholog_annotations":[{"gene_uniquename":"YLL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04547","reference_uniquename":"PMID:29761456"}],"product":"Non-essential component of the HAT-B histone acetyltransferase complex; localized to the nucleus; has a role in telomeric silencing; other members are Hat1p and Hat2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003945","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL022C"}


id: YLL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01460":null,"YLL023C":null},"has_protein_features":false,"name":"POM33","ortholog_annotations":[{"gene_uniquename":"YLL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01460","reference_uniquename":"PMID:29761456"}],"product":"Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003946","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL023C"}


id: YLL024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01186":null,"SJAG_04055":null,"YLL024C":null},"has_protein_features":false,"name":"SSA2","ortholog_annotations":[{"gene_uniquename":"YLL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01186","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04055","reference_uniquename":"PMID:29761456"}],"product":"HSP70 family ATP-binding protein; role in protein folding and vacuolar protein import; required for Ub-dependent degradation of short-lived proteins; associated with the chaperonin-containing T-complex; unique specificity in propagation of [URE3] prions and vacuolar degradation of gluconeogenic enzymes; contributes to tRNA nuclear import during starvation; targeted to vacuoles via the AP-3 pathway; localizes to exosomes during heat stress with a role in thermotolerance; 98% identity with Ssa1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003947","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL024C"}


id: YLL025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU17","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; YLL025W is not an essential gene","secondary_identifier":"SGD:S000003948","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL025W"}


id: YLL026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04187":null,"YLL026W":null},"has_protein_features":false,"name":"HSP104","ortholog_annotations":[{"gene_uniquename":"YLL026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04187","reference_uniquename":"PMID:29761456"}],"product":"Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate denatured, protein aggregates; responds to stresses (heat, ethanol, and sodium arsenite); required for the protein aggregate solid-to-liquid phase transition and dispersal of liquid condensates; involved in [PSI+] propagation; potentiated variants eliminate TDP-43 cytoplasmic aggregates to reduce proteotoxicity; becomes more abundant and forms cytoplasmic foci during replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003949","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL026W"}


id: YLL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03701":null,"YLL027W":null},"has_protein_features":false,"name":"ISA1","ortholog_annotations":[{"gene_uniquename":"YLL027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03701","reference_uniquename":"PMID:29761456"}],"product":"Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins; human ISCA1 can complement isa1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003950","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL027W"}


id: YLL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02059":null,"SJAG_02060":null,"YLL028W":null},"has_protein_features":false,"name":"TPO1","ortholog_annotations":[{"gene_uniquename":"YLL028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02059","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02060","reference_uniquename":"PMID:29761456"}],"product":"Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003951","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL028W"}


id: YLL029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00969":null,"YLL029W":null},"has_protein_features":false,"name":"FRA1","ortholog_annotations":[{"gene_uniquename":"YLL029W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00969","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003952","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL029W"}


id: YLL030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRT7","product":"Putative protein of unknown function; conserved across S. cerevisiae strains; identified in a screen for mutants with increased levels of rDNA transcription","secondary_identifier":"SGD:S000003953","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL030C"}


id: YLL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03506":null,"YLL031C":null},"has_protein_features":false,"name":"GPI13","ortholog_annotations":[{"gene_uniquename":"YLL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03506","reference_uniquename":"PMID:29761456"}],"product":"ER membrane localized phosphoryltransferase; adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003954","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL031C"}


id: YLL032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04521":null,"YLL032C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLL032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04521","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003955","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL032C"}


id: YLL033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC19","product":"Protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci","secondary_identifier":"SGD:S000003956","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL033W"}


id: YLL034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04599":null,"YLL034C":null},"has_protein_features":false,"name":"RIX7","ortholog_annotations":[{"gene_uniquename":"YLL034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04599","reference_uniquename":"PMID:29761456"}],"product":"Putative ATPase of the AAA family; required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003957","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL034C"}


id: YLL035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03789":null,"YLL035W":null},"has_protein_features":false,"name":"GRC3","ortholog_annotations":[{"gene_uniquename":"YLL035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03789","reference_uniquename":"PMID:29761456"}],"product":"Polynucleotide kinase present on rDNA; required for efficient transcription termination by RNA polymerase I; functions with Las1p in a conserved mechanism to cleave pre-rRNA at a specific site during rRNA processing and ribosome biogenesis; required for cell growth; mRNA is cell-cycle regulated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003958","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL035W"}


id: YLL036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04783":null,"YLL036C":null},"has_protein_features":false,"name":"PRP19","ortholog_annotations":[{"gene_uniquename":"YLL036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04783","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003959","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL036C"}


id: YLL037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor","secondary_identifier":"SGD:S000003960","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL037W"}


id: YLL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04644":null,"YLL038C":null},"has_protein_features":false,"name":"ENT4","ortholog_annotations":[{"gene_uniquename":"YLL038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04644","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003961","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL038C"}


id: YLL039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00452":null,"YLL039C":null},"has_protein_features":false,"name":"UBI4","ortholog_annotations":[{"gene_uniquename":"YLL039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00452","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via ubiquitin-26S proteasome system; essential for cellular stress response; encoded as polyubiquitin precursor comprised of 5 head-to-tail repeats; number of repeats is evolutionarily unstable within and between yeast species; protein abundance increases in response to DNA replication stress; implicated as modulator of replicative lifespan and meiotic recombination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003962","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL039C"}


id: YLL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01229":null,"SJAG_16459":null,"YLL040C":null},"has_protein_features":false,"name":"VPS13","ortholog_annotations":[{"gene_uniquename":"YLL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01229","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16459","reference_uniquename":"PMID:29761456"}],"product":"Lipid transport protein; involved in vacuolar protein sorting, protein retention in the Golgi, prospore membrane formation and sporulation; required for mitochondrial integrity and ER packaging into autophagosomes during cortical reticulophagy; peripheral membrane protein found at the prospore membrane and at membrane contact sites; contains a PH-like domain; homologous to human CHAC and COH1, involved in Chorea-acanthocytosis and Cohen syndrome, respectively","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003963","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL040C"}


id: YLL041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00260":null,"YLL041C":null},"has_protein_features":false,"name":"SDH2","ortholog_annotations":[{"gene_uniquename":"YLL041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00260","reference_uniquename":"PMID:29761456"}],"product":"Iron-sulfur protein subunit of succinate dehydrogenase; the complex couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; other members are Sdh1p, Sdh3p, and Sdh4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003964","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL041C"}


id: YLL042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01251":null,"YLL042C":null},"has_protein_features":false,"name":"ATG10","ortholog_annotations":[{"gene_uniquename":"YLL042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01251","reference_uniquename":"PMID:29761456"}],"product":"Conserved E2-like conjugating enzyme; mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003965","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL042C"}


id: YLL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FPS1","product":"Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in transport of acetate, arsenite, and antimonite; key factor in maintaining redox balance by mediating passive diffusion of glycerol; phosphorylated by Hog1p and Slt2p MAPK; deletion improves xylose fermentation; regulated by Rgc1p and Ask10p, which are regulated by Hog1p phosphorylation under osmotic stress; phosphorylation by Ypk1p required to maintain an open state","secondary_identifier":"SGD:S000003966","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL043W"}


id: YLL044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant","secondary_identifier":"SGD:S000003967","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL044W"}


id: YLL045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00537":null,"YLL045C":null},"has_protein_features":false,"name":"RPL8B","ortholog_annotations":[{"gene_uniquename":"YLL045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00537","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB during assembly of large subunit; binds Domain I of 25S, 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; RPL8B has paralog RPL8A from whole genome duplication; RPL8A or RPL8B ribosomes not functionally interchangeable; proportions of Rpl8ap, Rpl8bp in 80S ribosome differ in glucose and glycerol; homologous to mammalian ribosomal protein L7A, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003968","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL045C"}


id: YLL046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04863":null,"YLL046C":null},"has_protein_features":false,"name":"RNP1","ortholog_annotations":[{"gene_uniquename":"YLL046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04863","reference_uniquename":"PMID:29761456"}],"product":"Ribonucleoprotein that contains two RNA recognition motifs (RRM); RNP1 has a paralog, SBP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003969","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL046C"}


id: YLL047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1","secondary_identifier":"SGD:S000003970","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL047W"}


id: YLL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01344":null,"SJAG_03785":null,"SJAG_05213":null,"YLL048C":null},"has_protein_features":false,"name":"YBT1","ortholog_annotations":[{"gene_uniquename":"YLL048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01344","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03785","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05213","reference_uniquename":"PMID:29761456"}],"product":"Transporter of ATP-binding cassette (ABC) family; targeted to vacuole via AP-3 pathway; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003971","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL048C"}


id: YLL049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LDB18","product":"Component of the dynactin complex; dynactin is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24","secondary_identifier":"SGD:S000003972","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL049W"}


id: YLL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03025":null,"YLL050C":null},"has_protein_features":false,"name":"COF1","ortholog_annotations":[{"gene_uniquename":"YLL050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03025","reference_uniquename":"PMID:29761456"}],"product":"Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003973","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL050C"}


id: YLL051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04743":null,"YLL051C":null},"has_protein_features":false,"name":"FRE6","ortholog_annotations":[{"gene_uniquename":"YLL051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003974","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL051C"}


id: YLL052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AQY2","product":"Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains","secondary_identifier":"SGD:S000003975","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL052C"}


id: YLL053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin","secondary_identifier":"SGD:S000003976","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL053C"}


id: YLL054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function with similarity to Pip2p; an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene","secondary_identifier":"SGD:S000003977","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL054C"}


id: YLL055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04295":null,"YLL055W":null},"has_protein_features":false,"name":"YCT1","ortholog_annotations":[{"gene_uniquename":"YLL055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04295","reference_uniquename":"PMID:29761456"}],"product":"High-affinity cysteine-specific transporter; has similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003978","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL055W"}


id: YLL056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"NADH-dependent aldehyde reductase; reduces many aldehyde compounds including glycolaldehyde, formaldehyde and furfural; transcription unregulated by furfural, 5-hydroxymethylfurfural (HMF) and the mycotoxin patulin; expression increased by multidrug resistance transcription factors Yrm1p and Yrr1p; member of atypical subgroup 7 of the short-chain dehydrogenase/reductase (SDR) family; localizes to the cytoplasm; SWAT-GFP and mCherry fusion proteins localize to the ER and vacuole respectively","secondary_identifier":"SGD:S000003979","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL056C"}


id: YLL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"JLP1","product":"Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation","secondary_identifier":"SGD:S000003980","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL057C"}


id: YLL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03102":null,"YLL058W":null},"has_protein_features":false,"name":"HSU1","ortholog_annotations":[{"gene_uniquename":"YLL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03102","reference_uniquename":"PMID:29761456"}],"product":"Inefficient homocysteine synthase; catalyzes de novo homocysteine biosynthesis; capable of catalyzing same reaction as Met17p; affects S-methylmethionine metabolism; similar to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; HSU1 is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003981","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL058W"}


id: YLL059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003982","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL059C"}


id: YLL060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GTT2","product":"Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003983","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL060C"}


id: YLL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MMP1","product":"High-affinity S-methylmethionine permease; required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p","secondary_identifier":"SGD:S000003984","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL061W"}


id: YLL062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04425":null,"YLL062C":null},"has_protein_features":false,"name":"MHT1","ortholog_annotations":[{"gene_uniquename":"YLL062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04425","reference_uniquename":"PMID:29761456"}],"product":"S-methylmethionine-homocysteine methyltransferase; functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003985","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL062C"}


id: YLL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00020":null,"SJAG_00021":null,"SJAG_00075":null,"SJAG_01363":null,"SJAG_02126":null,"SJAG_02127":null,"SJAG_02940":null,"YLL063C":null},"has_protein_features":false,"name":"AYT1","ortholog_annotations":[{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00020","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00021","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00075","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01363","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02126","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02127","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02940","reference_uniquename":"PMID:26896847"}],"product":"Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis; localized to peroxisomes","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000003986","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL063C"}


id: YLL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU18","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau6p","secondary_identifier":"SGD:S000003987","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL064C"}


id: YLL065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps chromosome XII telomeric element core sequences","secondary_identifier":"SGD:S000003988","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL065W"}


id: YLL066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative Y' element ATP-dependent helicase; YLL066C is not an essential gene","secondary_identifier":"SGD:S000003989","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL066C"}


id: YLL066W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YLL066C","secondary_identifier":"SGD:S000028671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL066W-A"}


id: YLL066W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; overexpression causes a cell cycle delay or arrest","secondary_identifier":"SGD:S000028672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL066W-B"}


id: YLL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative Y' element ATP-dependent helicase","secondary_identifier":"SGD:S000003990","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL067C"}


id: YLL067W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps YLL067C","secondary_identifier":"SGD:S000028673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL067W-A"}


id: YLR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00732":null,"YLR001C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00732","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003991","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR001C"}


id: YLR002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00311":null,"YLR002C":null},"has_protein_features":false,"name":"NOC3","ortholog_annotations":[{"gene_uniquename":"YLR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00311","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003992","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR002C"}


id: YLR003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01115":null,"YLR003C":null},"has_protein_features":false,"name":"CMS1","ortholog_annotations":[{"gene_uniquename":"YLR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01115","reference_uniquename":"PMID:29761456"}],"product":"Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003993","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR003C"}


id: YLR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02139":null,"SJAG_05182":null,"YLR004C":null},"has_protein_features":false,"name":"THI73","ortholog_annotations":[{"gene_uniquename":"YLR004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02139","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05182","reference_uniquename":"PMID:29761456"}],"product":"Putative plasma membrane permease; proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003994","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR004C"}


id: YLR005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00758":null,"YLR005W":null},"has_protein_features":false,"name":"SSL1","ortholog_annotations":[{"gene_uniquename":"YLR005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00758","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the core form of RNA polymerase transcription factor TFIIH; has both protein kinase and DNA-dependent ATPase/helicase activities; essential for transcription and nucleotide excision repair; interacts with Tfb4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003995","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR005W"}


id: YLR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00318":null,"YLR006C":null},"has_protein_features":false,"name":"SSK1","ortholog_annotations":[{"gene_uniquename":"YLR006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00318","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic phosphorelay intermediate osmosensor and regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003996","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR006C"}


id: YLR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05323":null,"YLR007W":null},"has_protein_features":false,"name":"NSE1","ortholog_annotations":[{"gene_uniquename":"YLR007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05323","reference_uniquename":"PMID:29761456"}],"product":"Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003997","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR007W"}


id: YLR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01597":null,"YLR008C":null},"has_protein_features":false,"name":"PAM18","ortholog_annotations":[{"gene_uniquename":"YLR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01597","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the import motor (PAM complex); the PAM complex is a  component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003998","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR008C"}


id: YLR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04395":null,"YLR009W":null},"has_protein_features":false,"name":"RLP24","ortholog_annotations":[{"gene_uniquename":"YLR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04395","reference_uniquename":"PMID:29761456"}],"product":"Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003999","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR009W"}


id: YLR010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04245":null,"YLR010C":null},"has_protein_features":false,"name":"TEN1","ortholog_annotations":[{"gene_uniquename":"YLR010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04245","reference_uniquename":"PMID:29761456"}],"product":"Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p; similar to human Ten1 which is critical for the telomeric function of the CST (Cdc13p-Stn1p-Ten1p) complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004000","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR010C"}


id: YLR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LOT6","product":"FMN-dependent NAD(P)H:quinone reductase; role in apoptosis-like cell death; may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions","secondary_identifier":"SGD:S000004001","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR011W"}


id: YLR012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YLR012C is not an essential gene","secondary_identifier":"SGD:S000004002","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR012C"}


id: YLR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GAT3","product":"Protein containing GATA family zinc finger motifs; involved in spore wall assembly; sequence similarity to GAT4, and the double mutant gat3 gat4 exhibits reduced dityrosine fluorescence relative to the single mutants","secondary_identifier":"SGD:S000004003","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR013W"}


id: YLR014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PPR1","product":"Zinc finger transcription factor; contains a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p","secondary_identifier":"SGD:S000004004","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR014C"}


id: YLR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00896":null,"YLR015W":null},"has_protein_features":false,"name":"BRE2","ortholog_annotations":[{"gene_uniquename":"YLR015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00896","reference_uniquename":"PMID:29761456"}],"product":"Subunit of COMPASS (Set1C) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004005","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR015W"}


id: YLR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PML1","product":"Subunit of the RES complex; RES complex is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p","secondary_identifier":"SGD:S000004006","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR016C"}


id: YLR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03881":null,"YLR017W":null},"has_protein_features":false,"name":"MEU1","ortholog_annotations":[{"gene_uniquename":"YLR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03881","reference_uniquename":"PMID:29761456"}],"product":"Methylthioadenosine phosphorylase (MTAP); catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004007","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR017W"}


id: YLR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03281":null,"YLR018C":null},"has_protein_features":false,"name":"POM34","ortholog_annotations":[{"gene_uniquename":"YLR018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03281","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004008","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR018C"}


id: YLR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02389":null,"SJAG_04128":null,"YLR019W":null},"has_protein_features":false,"name":"PSR2","ortholog_annotations":[{"gene_uniquename":"YLR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02389","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04128","reference_uniquename":"PMID:29761456"}],"product":"Putative plasma membrane phosphatase; involved in the general stress response and inactivating dephosphorylation of Mep2p; required along with Psr1p and binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through Msn2p dephosphorylation, and for inhibition of TORC1 in response to limiting amino acids; regulates the sodium ion stress response with Psr1p; member of the HAD family of protein phosphatases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004009","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR019W"}


id: YLR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YEH2","product":"Steryl ester hydrolase; catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; YEH2 has a paralog, YEH1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004010","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR020C"}


id: YLR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04602":null,"YLR021W":null},"has_protein_features":false,"name":"IRC25","ortholog_annotations":[{"gene_uniquename":"YLR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04602","reference_uniquename":"PMID:29761456"}],"product":"Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004011","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR021W"}


id: YLR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04491":null,"YLR022C":null},"has_protein_features":false,"name":"SDO1","ortholog_annotations":[{"gene_uniquename":"YLR022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04491","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF) for Ria1p; essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004012","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR022C"}


id: YLR023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02080":null,"YLR023C":null},"has_protein_features":false,"name":"IZH3","ortholog_annotations":[{"gene_uniquename":"YLR023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02080","reference_uniquename":"PMID:29761456"}],"product":"Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004013","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR023C"}


id: YLR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01253":null,"SJAG_04619":null,"YLR024C":null},"has_protein_features":false,"name":"UBR2","ortholog_annotations":[{"gene_uniquename":"YLR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01253","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04619","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic ubiquitin-protein ligase (E3); component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex required for the ubiquitination and degradation of Rpn4p; mediates formation of the ternary complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004014","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR024C"}


id: YLR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01242":null,"YLR025W":null},"has_protein_features":false,"name":"SNF7","ortholog_annotations":[{"gene_uniquename":"YLR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01242","reference_uniquename":"PMID:29761456"}],"product":"One of four core subunits of the ESCRT-III complex; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes; subunit of the endosomal sorting complex required for transport III (ESCRT-III) that forms flat spirals on lipid monolayers as part of the complexes role in driving membrane abscission","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004015","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR025W"}


id: YLR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03552":null,"YLR026C":null},"has_protein_features":false,"name":"SED5","ortholog_annotations":[{"gene_uniquename":"YLR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03552","reference_uniquename":"PMID:29761456"}],"product":"cis-Golgi t-SNARE syntaxin; required for vesicular transport between the ER and the Golgi complex; binds at least 9 SNARE proteins; plays a role in autophagy by regulating formation of autophagic vesicles in Golgi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004016","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR026C"}


id: YLR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03306":null,"YLR027C":null},"has_protein_features":false,"name":"AAT2","ortholog_annotations":[{"gene_uniquename":"YLR027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03306","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic aspartate aminotransferase involved in the metabolism of nitrogen and amino acids such as aspartate; localizes to and functions in peroxisomes in oleate-grown cells; moonlighting role as a ribosome-associated protein that modulates translation in response to stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004017","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR027C"}


id: YLR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04681":null,"YLR028C":null},"has_protein_features":false,"name":"ADE16","ortholog_annotations":[{"gene_uniquename":"YLR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04681","reference_uniquename":"PMID:29761456"}],"product":"Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004018","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR028C"}


id: YLR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03919":null,"SJAG_04478":null,"YLR029C":null},"has_protein_features":false,"name":"RPL15A","ortholog_annotations":[{"gene_uniquename":"YLR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03919","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04478","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004019","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR029C"}


id: YLR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W","secondary_identifier":"SGD:S000004020","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR030W"}


id: YLR031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W; YLR031W has a paralog, YMR124W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004021","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR031W"}


id: YLR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02521":null,"YLR032W":null},"has_protein_features":false,"name":"RAD5","ortholog_annotations":[{"gene_uniquename":"YLR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02521","reference_uniquename":"PMID:29761456"}],"product":"DNA helicase/Ubiquitin ligase; involved in error-free DNA damage tolerance (DDT), replication fork regression during postreplication repair by template switching, and error-prone translesion synthesis; required for UV and MMS-associated unequal sister chromatid exchange (SCE) but not for double-strand break associated unequal SCE; promotes synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; human homolog HLTF can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004022","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR032W"}


id: YLR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03758":null,"YLR033W":null},"has_protein_features":false,"name":"RSC58","ortholog_annotations":[{"gene_uniquename":"YLR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03758","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004023","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR033W"}


id: YLR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01007":null,"YLR034C":null},"has_protein_features":false,"name":"SMF3","ortholog_annotations":[{"gene_uniquename":"YLR034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01007","reference_uniquename":"PMID:29761456"}],"product":"Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of Nramp family of metal transport proteins; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004024","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR034C"}


id: YLR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MLH2","product":"Protein involved in mismatch repair and meiotic recombination; only certain frameshift intermediates are mismatch repair substrates; forms a complex with Mlh1p, plays accessory role in stimulating activity of MLH1/PMS1 complex","secondary_identifier":"SGD:S000004025","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR035C"}


id: YLR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein","secondary_identifier":"SGD:S000004026","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR036C"}


id: YLR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU23","product":"Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth","secondary_identifier":"SGD:S000004027","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR037C"}


id: YLR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02504":null,"YLR038C":null},"has_protein_features":false,"name":"COX12","ortholog_annotations":[{"gene_uniquename":"YLR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02504","reference_uniquename":"PMID:29761456"}],"product":"Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly and activity of cytochrome c oxidase; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004028","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR038C"}


id: YLR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00143":null,"YLR039C":null},"has_protein_features":false,"name":"RIC1","ortholog_annotations":[{"gene_uniquename":"YLR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00143","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004029","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR039C"}


id: YLR040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AFB1","product":"MATalpha-specific a-factor blocker; contributes to mating efficiency under certain conditions; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W","secondary_identifier":"SGD:S000004030","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR040C"}


id: YLR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C","secondary_identifier":"SGD:S000004031","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR041W"}


