# genes

id: YBL003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01873":null,"SJAG_03942":null,"YBL003C":null},"has_protein_features":false,"name":"HTA2","ortholog_annotations":[{"gene_uniquename":"YBL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01873","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03942","reference_uniquename":"PMID:29761456"}],"product":"Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000099","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL003C"}


id: YBL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05186":null,"YBL004W":null},"has_protein_features":false,"name":"UTP20","ortholog_annotations":[{"gene_uniquename":"YBL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05186","reference_uniquename":"PMID:29761456"}],"product":"Component of the small-subunit (SSU) processome; SSU processome is involved in the biogenesis of the 18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000100","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL004W"}


id: YBL005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PDR3","product":"Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting PDRE sites (PDR responsive elements); has a role in response to drugs and organic solvents; post-translationally up-regulated in cells lacking functional mitochondrial genome; involved in diauxic shift; relative distribution to nucleus increases upon DNA replication stress; APCC(Cdh1) substrate","secondary_identifier":"SGD:S000000101","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL005W"}


id: YBL006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LDB7","product":"Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions","secondary_identifier":"SGD:S000000102","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL006C"}


id: YBL006W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene LDB7/YBL006C","secondary_identifier":"SGD:S000028596","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL006W-A"}


id: YBL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00521":null,"YBL007C":null},"has_protein_features":false,"name":"SLA1","ortholog_annotations":[{"gene_uniquename":"YBL007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00521","reference_uniquename":"PMID:29761456"}],"product":"Cytoskeletal protein binding protein; required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000103","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL007C"}


id: YBL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00913":null,"SJAG_00925":null,"YBL008W":null},"has_protein_features":false,"name":"HIR1","ortholog_annotations":[{"gene_uniquename":"YBL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00913","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00925","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000104","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL008W"}


id: YBL008W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028529","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL008W-A"}


id: YBL009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00678":null,"YBL009W":null},"has_protein_features":false,"name":"ALK2","ortholog_annotations":[{"gene_uniquename":"YBL009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00678","reference_uniquename":"PMID:29761456"}],"product":"Atypical protein kinase; along with its paralog, ALK1, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of formins and polarisome components in mitosis, and survival after spindle assembly checkpoint delay; negatively regulates the morphogenesis checkpoint in response to polarity insults in opposition to ALK1; phosphorylated in response to DNA damage; similar to mammalian haspins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000105","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL009W"}


id: YBL010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02269":null,"YBL010C":null},"has_protein_features":false,"name":"LAA2","ortholog_annotations":[{"gene_uniquename":"YBL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02269","reference_uniquename":"PMID:29761456"}],"product":"Clathrin adaptor (adaptin) accessory protein; physically interacts with and is involved in localization of clathrin adaptor protein complex-1 (AP-1); green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000106","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL010C"}


id: YBL011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02654":null,"SJAG_03305":null,"YBL011W":null},"has_protein_features":false,"name":"SCT1","ortholog_annotations":[{"gene_uniquename":"YBL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02654","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03305","reference_uniquename":"PMID:26896847"}],"product":"Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; dual substrate-specific acyltransferase of the glycerolipid biosynthesis pathway; prefers 16-carbon fatty acids; similar to Gpt2p; gene is constitutively transcribed","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000107","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL011W"}


id: YBL012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000108","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL012C"}


id: YBL013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01368":null,"YBL013W":null},"has_protein_features":false,"name":"FMT1","ortholog_annotations":[{"gene_uniquename":"YBL013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01368","reference_uniquename":"PMID:29761456"}],"product":"Methionyl-tRNA formyltransferase; catalyzes formylation of mitochondria initiator Met-tRNA and residual cytosolic Met-tRNA due to inefficient translocation into the mitochondrial matrix; starvation or stationary phase entry increases Gcn2p phosphorylation-mediated cytosolic retention of Fmt1p, enhancing N-terminal protein formylation and ultimately N-end rule pathway mediated destruction that involves the Psh1p ubiquitin ligase; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000109","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL013W"}


id: YBL014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00202":null,"YBL014C":null},"has_protein_features":false,"name":"RRN6","ortholog_annotations":[{"gene_uniquename":"YBL014C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00202","reference_uniquename":"PMID:29761456"}],"product":"Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000110","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL014C"}


id: YBL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02769":null,"SJAG_02985":null,"YBL015W":null},"has_protein_features":false,"name":"ACH1","ortholog_annotations":[{"gene_uniquename":"YBL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02769","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02985","reference_uniquename":"PMID:26896847"}],"product":"Protein with CoA transferase activity; particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000111","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL015W"}


id: YBL016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02923":null,"YBL016W":null},"has_protein_features":false,"name":"FUS3","ortholog_annotations":[{"gene_uniquename":"YBL016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02923","reference_uniquename":"PMID:29761456"}],"product":"Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its; inhibits recruitment of Ste5p, Cdc42p-mediated asymmetry and mating morphogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000112","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL016W"}


id: YBL017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01488":null,"YBL017C":null},"has_protein_features":false,"name":"PEP1","ortholog_annotations":[{"gene_uniquename":"YBL017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01488","reference_uniquename":"PMID:29761456"}],"product":"Type I transmembrane sorting receptor for multiple vacuolar hydrolases; plays role in post-ER quality control in the Golgi, involved in protein targeting from the endoplasmic reticulum to the vacuole for degradation; cycles between late-Golgi and prevacuolar endosome-like compartments; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000113","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL017C"}


id: YBL018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03234":null,"YBL018C":null},"has_protein_features":false,"name":"POP8","ortholog_annotations":[{"gene_uniquename":"YBL018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03234","reference_uniquename":"PMID:29761456"}],"product":"Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000114","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL018C"}


id: YBL019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02298":null,"YBL019W":null},"has_protein_features":false,"name":"APN2","ortholog_annotations":[{"gene_uniquename":"YBL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02298","reference_uniquename":"PMID:29761456"}],"product":"Class II abasic (AP) endonuclease involved in repair of DNA damage; also possesses 3'-diesterase and PCNA-stiimulated 3' to 5' exonuclease activities; resolves blocked 3' ends that result from removal of misincorporated nucleotides; frays and cleaves 3' DNA termini facilitating 3' DNA-end healing via endonucleolytic cleavage;  homolog of human APEX2 and E. coli exoIII","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000115","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL019W"}


id: YBL020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03774":null,"YBL020W":null},"has_protein_features":false,"name":"RFT1","ortholog_annotations":[{"gene_uniquename":"YBL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03774","reference_uniquename":"PMID:29761456"}],"product":"Membrane protein required for translocation of Man5GlcNac2-PP-Dol; required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000116","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL020W"}


id: YBL021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05247":null,"YBL021C":null},"has_protein_features":false,"name":"HAP3","ortholog_annotations":[{"gene_uniquename":"YBL021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05247","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000117","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL021C"}


id: YBL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00984":null,"YBL022C":null},"has_protein_features":false,"name":"PIM1","ortholog_annotations":[{"gene_uniquename":"YBL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00984","reference_uniquename":"PMID:29761456"}],"product":"ATP-dependent Lon protease; involved in degradation of misfolded mitochondrial proteins; required for mitochondrial maintenance and biogenesis; regulates mitochondrial DNA copy number with Mrx6p; subunit of a complex containing Mrx6p, Pet20p, and Mam33p that may regulate mtDNA replication; protease-independent, chaperone-like function in mitochondrial membrane complex assembly; localizes to the mitochondrial matrix","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000118","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL022C"}


id: YBL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02348":null,"YBL023C":null},"has_protein_features":false,"name":"MCM2","ortholog_annotations":[{"gene_uniquename":"YBL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02348","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; binds and transfers parental H3-H4 to Pol32p facilitating the transfer of parental histones to the lagging strand via Pol1p during DNA replication; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000119","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL023C"}


id: YBL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00325":null,"SJAG_02099":null,"YBL024W":null},"has_protein_features":false,"name":"NCL1","ortholog_annotations":[{"gene_uniquename":"YBL024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00325","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02099","reference_uniquename":"PMID:29761456"}],"product":"S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000120","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL024W"}


id: YBL025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05331":null,"YBL025W":null},"has_protein_features":false,"name":"RRN10","ortholog_annotations":[{"gene_uniquename":"YBL025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05331","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000121","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL025W"}


id: YBL026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02469":null,"YBL026W":null},"has_protein_features":false,"name":"LSM2","ortholog_annotations":[{"gene_uniquename":"YBL026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02469","reference_uniquename":"PMID:29761456"}],"product":"Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000122","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL026W"}


id: YBL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00384":null,"SJAG_00765":null,"YBL027W":null},"has_protein_features":false,"name":"RPL19B","ortholog_annotations":[{"gene_uniquename":"YBL027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00384","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00765","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000123","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL027W"}


id: YBL028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03080":null,"YBL028C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBL028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03080","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000124","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL028C"}


id: YBL029C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica","secondary_identifier":"SGD:S000007591","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL029C-A"}


id: YBL029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Non-essential protein of unknown function","secondary_identifier":"SGD:S000000125","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL029W"}


id: YBL030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02050":null,"YBL030C":null},"has_protein_features":false,"name":"PET9","ortholog_annotations":[{"gene_uniquename":"YBL030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02050","reference_uniquename":"PMID:29761456"}],"product":"Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; also functions in peroxisomes; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication; human homolog SLC25A4 implicated in progressive external ophthalmoplegia can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000126","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL030C"}


id: YBL031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SHE1","product":"Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function","secondary_identifier":"SGD:S000000127","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL031W"}


id: YBL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04825":null,"YBL032W":null},"has_protein_features":false,"name":"HEK2","ortholog_annotations":[{"gene_uniquename":"YBL032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04825","reference_uniquename":"PMID:29761456"}],"product":"RNA binding protein involved in asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K; increases mRNA stability by binding (CNN)n repeat elements","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000128","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL032W"}


id: YBL033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00376":null,"YBL033C":null},"has_protein_features":false,"name":"RIB1","ortholog_annotations":[{"gene_uniquename":"YBL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00376","reference_uniquename":"PMID:29761456"}],"product":"GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000129","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL033C"}


id: YBL034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04841":null,"YBL034C":null},"has_protein_features":false,"name":"STU1","ortholog_annotations":[{"gene_uniquename":"YBL034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04841","reference_uniquename":"PMID:29761456"}],"product":"Microtubule plus-end-tracking non-motor protein; binds to MTs, stabilizing interpolar MT plus ends, facilitating polymerization of spindle MTs and producing an outward force on spindle poles; required for structural integrity of the mitotic spindle; binds detached kinetochores (KTs) and promotes capture; relocalizes to MTs and stabilizes the spindle once captured KTs reach a spindle pole; localizes to the spindle, spindles poles, and detached KTs; CLASP family member homologous to human CLASP1/2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000130","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL034C"}


id: YBL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02172":null,"YBL035C":null},"has_protein_features":false,"name":"POL12","ortholog_annotations":[{"gene_uniquename":"YBL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02172","reference_uniquename":"PMID:29761456"}],"product":"B subunit of DNA polymerase alpha-primase complex; required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000131","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL035C"}


id: YBL036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05230":null,"YBL036C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBL036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05230","reference_uniquename":"PMID:29761456"}],"product":"Putative non-specific single-domain racemase; based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000132","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL036C"}


id: YBL037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01167":null,"YBL037W":null},"has_protein_features":false,"name":"APL3","ortholog_annotations":[{"gene_uniquename":"YBL037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01167","reference_uniquename":"PMID:29761456"}],"product":"Alpha-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000133","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL037W"}


id: YBL038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04689":null,"YBL038W":null},"has_protein_features":false,"name":"MRPL16","ortholog_annotations":[{"gene_uniquename":"YBL038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04689","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; homologous to bacterial L16 ribosomal protein; synthetic lethality with hac1 mutation suggests a possible role in synthesis of precursors for protein glycosylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000134","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL038W"}


id: YBL039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05024":null,"YBL039C":null},"has_protein_features":false,"name":"URA7","ortholog_annotations":[{"gene_uniquename":"YBL039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05024","reference_uniquename":"PMID:29761456"}],"product":"Major CTP synthase isozyme (see also URA8); catalyzes ATP-dependent transfer of amide nitrogen from glutamine to UTP, forming CTP, final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; targeted to vacuole via AP-3 pathway; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has paralog URA8 that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000135","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL039C"}


id: YBL039C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF URA7; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028814","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL039C-A"}


id: YBL039W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIN6","product":"Mitochondrial protein of unknown function; mCherry fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000028517","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL039W-B"}


id: YBL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02418":null,"YBL040C":null},"has_protein_features":false,"name":"ERD2","ortholog_annotations":[{"gene_uniquename":"YBL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02418","reference_uniquename":"PMID:29761456"}],"product":"HDEL receptor; an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000136","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL040C"}


id: YBL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00128":null,"YBL041W":null},"has_protein_features":false,"name":"PRE7","ortholog_annotations":[{"gene_uniquename":"YBL041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00128","reference_uniquename":"PMID:29761456"}],"product":"Beta 6 subunit of the 20S proteasome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000137","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL041W"}


id: YBL042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02147":null,"SJAG_04714":null,"YBL042C":null},"has_protein_features":false,"name":"FUI1","ortholog_annotations":[{"gene_uniquename":"YBL042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02147","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YBL042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04714","reference_uniquename":"PMID:29761456"}],"product":"High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000138","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL042C"}


id: YBL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM13","product":"Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000139","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL043W"}


id: YBL044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YBL044W is not an essential protein","secondary_identifier":"SGD:S000000140","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL044W"}


id: YBL045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02397":null,"YBL045C":null},"has_protein_features":false,"name":"COR1","ortholog_annotations":[{"gene_uniquename":"YBL045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02397","reference_uniquename":"PMID:29761456"}],"product":"Core subunit of the ubiquinol-cytochrome c reductase complex; the ubiquinol-cytochrome c reductase complex (bc1 complex) is a component of the mitochondrial inner membrane electron transport chain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000141","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL045C"}


id: YBL046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PSY4","product":"Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2","secondary_identifier":"SGD:S000000142","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL046W"}


id: YBL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02511":null,"SJAG_03044":null,"YBL047C":null},"has_protein_features":false,"name":"EDE1","ortholog_annotations":[{"gene_uniquename":"YBL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02511","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03044","reference_uniquename":"PMID:29761456"}],"product":"Endocytic adaptor; K63-specific Ub-chain binding protein involved in receptor endocytosis; scaffold protein that localizes to nascent endocytic sites after homo-oligomerization and organizes the endocytic machinery; role in autophagy of aberrant clathrin-mediated endocytosis protein condensates; binds membranes in a Ub-dependent manner; interacts with and functions upstream of Cmk2p to suppress stress-induced non-apoptotic cell death; putative cytokinesis regulator;  homolog of mammalian Eps15","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000143","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL047C"}


id: YBL048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRT1","product":"Putative protein of unknown function; conserved across S. cerevisiae strains; identified in a screen for mutants with increased levels of rDNA transcription","secondary_identifier":"SGD:S000000144","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL048W"}


id: YBL049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02003":null,"YBL049W":null},"has_protein_features":false,"name":"MOH1","ortholog_annotations":[{"gene_uniquename":"YBL049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02003","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function, essential for stationary phase survival; not required for growth on nonfermentable carbon sources; possibly linked with vacuolar transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000145","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL049W"}


id: YBL050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04909":null,"YBL050W":null},"has_protein_features":false,"name":"SEC17","ortholog_annotations":[{"gene_uniquename":"YBL050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04909","reference_uniquename":"PMID:29761456"}],"product":"Alpha-SNAP cochaperone; SNARE-complex adaptor for Sec18 (NSF) during the disassembly of postfusion cis-SNARE complexes; stimulates the ATPase activity of Sec18p; peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; similar to mammalian alpha-SNAP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000146","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL050W"}


id: YBL051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00563":null,"SJAG_04385":null,"YBL051C":null},"has_protein_features":false,"name":"PIN4","ortholog_annotations":[{"gene_uniquename":"YBL051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00563","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04385","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in G2/M phase progression and response to DNA damage; interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000147","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL051C"}


id: YBL052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02165":null,"YBL052C":null},"has_protein_features":false,"name":"SAS3","ortholog_annotations":[{"gene_uniquename":"YBL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02165","reference_uniquename":"PMID:29761456"}],"product":"Histone acetyltransferase catalytic subunit of NuA3 complex; acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000148","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL052C"}


id: YBL053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000149","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL053W"}


id: YBL054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TOD6","product":"PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; activated in stochastic pulses of nuclear localization","secondary_identifier":"SGD:S000000150","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL054W"}


id: YBL055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01163":null,"YBL055C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01163","reference_uniquename":"PMID:29761456"}],"product":"3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000151","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL055C"}


id: YBL056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03482":null,"SJAG_03893":null,"YBL056W":null},"has_protein_features":false,"name":"PTC3","ortholog_annotations":[{"gene_uniquename":"YBL056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03482","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03893","reference_uniquename":"PMID:29761456"}],"product":"Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000152","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL056W"}


id: YBL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05008":null,"YBL057C":null},"has_protein_features":false,"name":"PTH2","ortholog_annotations":[{"gene_uniquename":"YBL057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05008","reference_uniquename":"PMID:29761456"}],"product":"One of two mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth; see also PTH1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000153","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL057C"}


id: YBL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01467":null,"YBL058W":null},"has_protein_features":false,"name":"SHP1","ortholog_annotations":[{"gene_uniquename":"YBL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01467","reference_uniquename":"PMID:29761456"}],"product":"Substrate adaptor for Cdc48p; ubiquitin regulatory X (UBX) and Ub-associated (UBA) domain-containing protein that acts as a substrate recruiting cofactor; K48-specific Ub chain binding protein involved in ER-associated degradation (ERAD); positively regulates Glc7p protein phosphatase activity to promote growth and mitotic progression in complex with Cdc48p; regulated by nuclear Ub-dependent degradation (INMAD pathway) independent of the Asi and Doa10 complexes; homolog of human p47 (NSFL1C)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000154","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL058W"}


id: YBL059C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01140":null,"SJAG_05398":null,"YBL059C-A":null},"has_protein_features":false,"name":"CMC2","ortholog_annotations":[{"gene_uniquename":"YBL059C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01140","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL059C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05398","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in respiratory chain complex assembly or maintenance; protein of the mitochondrial intermembrane space; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007488","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL059C-A"}


id: YBL059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IAI11","product":"Putative mitochondrial protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; IAI11 has a paralog, YER093C-A, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000155","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL059W"}


id: YBL060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00216":null,"YBL060W":null},"has_protein_features":false,"name":"YEL1","ortholog_annotations":[{"gene_uniquename":"YBL060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00216","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000156","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL060W"}


id: YBL061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01453":null,"SJAG_02845":null,"YBL061C":null},"has_protein_features":false,"name":"SKT5","ortholog_annotations":[{"gene_uniquename":"YBL061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01453","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02845","reference_uniquename":"PMID:29761456"}],"product":"Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000157","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL061C"}


id: YBL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000158","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL062W"}


id: YBL063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04745":null,"YBL063W":null},"has_protein_features":false,"name":"KIP1","ortholog_annotations":[{"gene_uniquename":"YBL063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04745","reference_uniquename":"PMID:29761456"}],"product":"Kinesin-related motor protein; tracks plus-ends and stabilizes microtubules; required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000159","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL063W"}


id: YBL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRX1","product":"Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000000160","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL064C"}


id: YBL065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene","secondary_identifier":"SGD:S000000161","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL065W"}


id: YBL066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SEF1","product":"Putative transcription factor; has homolog in Kluyveromyces lactis","secondary_identifier":"SGD:S000000162","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL066C"}


id: YBL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00546":null,"YBL067C":null},"has_protein_features":false,"name":"UBP13","ortholog_annotations":[{"gene_uniquename":"YBL067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00546","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000163","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL067C"}


id: YBL068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03811":null,"YBL068W":null},"has_protein_features":false,"name":"PRS4","ortholog_annotations":[{"gene_uniquename":"YBL068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03811","reference_uniquename":"PMID:29761456"}],"product":"5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication; a missense mutation in the conserved residue R196 of its human homolog PRPS1 is pathogenic","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000164","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL068W"}


id: YBL068W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028530","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL068W-A"}


id: YBL069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AST1","product":"Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000165","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL069W"}


id: YBL070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000166","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL070C"}


id: YBL071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YBL071C is not an essential gene","secondary_identifier":"SGD:S000000167","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL071C"}


id: YBL071C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028597","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL071C-B"}


id: YBL071W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01418":null,"YBL071W-A":null},"has_protein_features":false,"name":"KTI11","ortholog_annotations":[{"gene_uniquename":"YBL071W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01418","reference_uniquename":"PMID:29761456"}],"product":"Zn-ribbon protein that co-purifies with Dph1 and Dph2; forms a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p; involved in modification of wobble nucleosides in tRNAs; forms a stable heterodimer with Ats1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL071W-A"}


id: YBL072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02020":null,"SJAG_04029":null,"YBL072C":null},"has_protein_features":false,"name":"RPS8A","ortholog_annotations":[{"gene_uniquename":"YBL072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02020","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04029","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000168","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL072C"}


id: YBL073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C","secondary_identifier":"SGD:S000000169","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL073W"}


id: YBL074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01547":null,"YBL074C":null},"has_protein_features":false,"name":"AAR2","ortholog_annotations":[{"gene_uniquename":"YBL074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01547","reference_uniquename":"PMID:29761456"}],"product":"Component of the U5 snRNP complex; required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000170","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL074C"}


id: YBL075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01186":null,"SJAG_04055":null,"YBL075C":null},"has_protein_features":false,"name":"SSA3","ortholog_annotations":[{"gene_uniquename":"YBL075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01186","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04055","reference_uniquename":"PMID:29761456"}],"product":"ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000171","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL075C"}


id: YBL076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03545":null,"YBL076C":null},"has_protein_features":false,"name":"ILS1","ortholog_annotations":[{"gene_uniquename":"YBL076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03545","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic isoleucine-tRNA synthetase; target of the G1-specific inhibitor reveromycin A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000172","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL076C"}


id: YBL077W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C","secondary_identifier":"SGD:S000000173","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL077W"}


id: YBL078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02414":null,"YBL078C":null},"has_protein_features":false,"name":"ATG8","ortholog_annotations":[{"gene_uniquename":"YBL078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02414","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-like protein conjugated to phosphatidylethanolamine (PE); role in membrane fusion and phagophore expansion during autophagosome formation; deconjugation is also required for biogenesis; targets Atg1p to autophagosomes; binds to the Atg1p-Atg13p complex, triggers its vacuolar degradation; role in vacuolar membrane protein turnover during early stationary phase; component of autophagosomes and Cvt vesicles; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000174","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL078C"}


id: YBL079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02757":null,"YBL079W":null},"has_protein_features":false,"name":"NUP170","ortholog_annotations":[{"gene_uniquename":"YBL079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02757","reference_uniquename":"PMID:29761456"}],"product":"Subunit of inner ring of nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; interacts with genomic regions that contain ribosomal protein and subtelomeric genes, where it functions in nucleosome positioning and as a repressor of transcription; both Nup170p and Nup157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000175","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL079W"}


id: YBL080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01577":null,"YBL080C":null},"has_protein_features":false,"name":"PET112","ortholog_annotations":[{"gene_uniquename":"YBL080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01577","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000176","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL080C"}


id: YBL081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport","secondary_identifier":"SGD:S000000177","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL081W"}


id: YBL082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04952":null,"YBL082C":null},"has_protein_features":false,"name":"ALG3","ortholog_annotations":[{"gene_uniquename":"YBL082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04952","reference_uniquename":"PMID:29761456"}],"product":"Dolichol-P-Man dependent alpha(1-3) mannosyltransferase; involved in synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins; G353A missense mutation in human ortholog ALG3 implicated in carbohydrate deficient glycoprotein syndrome type IV, which is characterized by microcephaly, severe epilepsy, minimal psychomotor development, partial deficiency of sialic acids in serum glycoproteins; wild-type human ALG3 can complement yeast alg3 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000178","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL082C"}


id: YBL083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3","secondary_identifier":"SGD:S000000179","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL083C"}


id: YBL084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01956":null,"YBL084C":null},"has_protein_features":false,"name":"CDC27","ortholog_annotations":[{"gene_uniquename":"YBL084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01956","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000180","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL084C"}


id: YBL085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01448":null,"YBL085W":null},"has_protein_features":false,"name":"BOI1","ortholog_annotations":[{"gene_uniquename":"YBL085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01448","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in polar growth, functionally redundant with Boi2p; required for fusion of secretory vesicles with plasma membrane at sites of polarized growth; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000181","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL085W"}


id: YBL086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04648":null,"YBL086C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBL086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04648","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000182","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL086C"}


id: YBL087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01087":null,"SJAG_03197":null,"YBL087C":null},"has_protein_features":false,"name":"RPL23A","ortholog_annotations":[{"gene_uniquename":"YBL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01087","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03197","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000183","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL087C"}


id: YBL088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03720":null,"YBL088C":null},"has_protein_features":false,"name":"TEL1","ortholog_annotations":[{"gene_uniquename":"YBL088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03720","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; binds to phosphatidylinositol-4-phosphate; acts with Red1p and Mec1p to promote interhomolog recombination by phosphorylation of Hop1; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000184","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL088C"}


id: YBL089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03256":null,"YBL089W":null},"has_protein_features":false,"name":"AVT5","ortholog_annotations":[{"gene_uniquename":"YBL089W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03256","reference_uniquename":"PMID:29761456"}],"product":"Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000185","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL089W"}


id: YBL090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04164":null,"YBL090W":null},"has_protein_features":false,"name":"MRP21","ortholog_annotations":[{"gene_uniquename":"YBL090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04164","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000186","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL090W"}


id: YBL091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06636":null,"YBL091C":null},"has_protein_features":false,"name":"MAP2","ortholog_annotations":[{"gene_uniquename":"YBL091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06636","reference_uniquename":"PMID:29761456"}],"product":"Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000187","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL091C"}


id: YBL091C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00053":null,"SJAG_03170":null,"YBL091C-A":null},"has_protein_features":false,"name":"SCS22","ortholog_annotations":[{"gene_uniquename":"YBL091C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00053","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL091C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03170","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect the ER and plasma membrane (PM); regulates PM PI4P levels by controlling access of the Sac1p phosphatase to its substrate, PI4P; human VAP homolog; similar to D. melanogaster inturned protein; SWAT-GFP and mCherry fusion proteins localize to the cytosol; SCS22 has a paralog, SCS2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007228","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL091C-A"}


id: YBL092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01565":null,"SJAG_01580":null,"YBL092W":null},"has_protein_features":false,"name":"RPL32","ortholog_annotations":[{"gene_uniquename":"YBL092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01565","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01580","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000188","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL092W"}


id: YBL093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02494":null,"YBL093C":null},"has_protein_features":false,"name":"ROX3","ortholog_annotations":[{"gene_uniquename":"YBL093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02494","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000189","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL093C"}


id: YBL094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W","secondary_identifier":"SGD:S000000190","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL094C"}


id: YBL095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01396":null,"SJAG_04007":null,"YBL095W":null},"has_protein_features":false,"name":"MRX3","ortholog_annotations":[{"gene_uniquename":"YBL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01396","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04007","reference_uniquename":"PMID:29761456"}],"product":"Protein that associates with mitochondrial ribosome; likely functions in cristae junction formation; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000191","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL095W"}


id: YBL096C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Non-essential protein of unknown function","secondary_identifier":"SGD:S000000192","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL096C"}


id: YBL097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00768":null,"YBL097W":null},"has_protein_features":false,"name":"BRN1","ortholog_annotations":[{"gene_uniquename":"YBL097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00768","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000193","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL097W"}


id: YBL098W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BNA4","product":"Kynurenine 3-monooxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; localizes to mitochondria and peroxisomes; putative therapeutic target for Huntington disease","secondary_identifier":"SGD:S000000194","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL098W"}


id: YBL099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02564":null,"YBL099W":null},"has_protein_features":false,"name":"ATP1","ortholog_annotations":[{"gene_uniquename":"YBL099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02564","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated; N-terminally propionylated in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000195","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL099W"}


id: YBL100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1","secondary_identifier":"SGD:S000000196","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL100C"}


id: YBL100W-C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028598","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL100W-C"}


id: YBL101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM21","product":"Alpha-arrestin, ubiquitin ligase adaptor for Rsp5p; regulates starvation- and substrate-induced Ub-dependent endocytosis of select plasma membrane localized amino acid transporters; substrate of Rsp5p-mediated Lys63-polyubiquitination and Ubp2-mediated deubiquitination; promoter contains several Gcn4p binding sites required for induction in response to starvation via Gcn4p and the general amino acid control pathway; ECM21 has a paralog, CSR2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000197","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL101C"}


id: YBL102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01027":null,"YBL102W":null},"has_protein_features":false,"name":"SFT2","ortholog_annotations":[{"gene_uniquename":"YBL102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01027","reference_uniquename":"PMID:29761456"}],"product":"Tetra-spanning membrane protein found mostly in the late Golgi; non-essential; can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000198","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL102W"}


id: YBL103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RTG3","product":"bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways; forms a complex with another bHLH/Zip protein, Rtg1p, to activate the pathways; target of Hog1p","secondary_identifier":"SGD:S000000199","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL103C"}


id: YBL103C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a protein; YBL103C-A was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YBL104C","secondary_identifier":"SGD:S000028531","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL103C-A"}


id: YBL104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00561":null,"YBL104C":null},"has_protein_features":false,"name":"SEA4","ortholog_annotations":[{"gene_uniquename":"YBL104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00561","reference_uniquename":"PMID:29761456"}],"product":"Subunit of SEACAT, a subcomplex of the SEA complex; Sea4p, along with Rtc1p and Mtc5p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; contains an N-terminal beta-propeller fold and a C-terminal RING motif","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000200","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL104C"}


id: YBL105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00610":null,"SJAG_01787":null,"YBL105C":null},"has_protein_features":false,"name":"PKC1","ortholog_annotations":[{"gene_uniquename":"YBL105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00610","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBL105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01787","reference_uniquename":"PMID:29761456"}],"product":"Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000201","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL105C"}


id: YBL106C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03754":null,"YBL106C":null},"has_protein_features":false,"name":"SRO77","ortholog_annotations":[{"gene_uniquename":"YBL106C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03754","reference_uniquename":"PMID:29761456"}],"product":"Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; interacts with SNARE protein Sec9p; homolog of Drosophila lethal giant larvae tumor suppressor; SRO77 has a paralog, SRO7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000202","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL106C"}


id: YBL107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02917":null,"YBL107C":null},"has_protein_features":false,"name":"MIX23","ortholog_annotations":[{"gene_uniquename":"YBL107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02917","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000203","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL107C"}


id: YBL107W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the Ty2 LTR YBLWdelta2; YBL107W-A has a paralog, YER138W-A, that arose from a single-locus duplication","secondary_identifier":"SGD:S000007229","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL107W-A"}


id: YBL108C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU9","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","secondary_identifier":"SGD:S000007592","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL108C-A"}


id: YBL108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000204","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL108W"}


id: YBL109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002150","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL109W"}


id: YBL111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Helicase-like protein encoded within the telomeric Y' element; relocalizes from mitochondrion to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000002151","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL111C"}


id: YBL112C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YBL112C is contained within TEL02L","secondary_identifier":"SGD:S000002152","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL112C"}


id: YBL113C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Helicase-like protein encoded within the telomeric Y' element","secondary_identifier":"SGD:S000002153","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL113C"}


id: YBL113W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028599","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBL113W-A"}


id: YBR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04859":null,"YBR001C":null},"has_protein_features":false,"name":"NTH2","ortholog_annotations":[{"gene_uniquename":"YBR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04859","reference_uniquename":"PMID:29761456"}],"product":"Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000205","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR001C"}


id: YBR002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02163":null,"YBR002C":null},"has_protein_features":false,"name":"RER2","ortholog_annotations":[{"gene_uniquename":"YBR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02163","reference_uniquename":"PMID:29761456"}],"product":"Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1; major enzyme of polyprenol synthesis in both the endoplasmic reticulum (ER) and in lipid droplets; participates in ER protein sorting; human ortholog DHDDS functionally complements the heat sensitive growth defect of a ts allele, and is associated with retinitis pigmentosa","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000206","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR002C"}


id: YBR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01865":null,"SJAG_04568":null,"YBR003W":null},"has_protein_features":false,"name":"COQ1","ortholog_annotations":[{"gene_uniquename":"YBR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01865","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04568","reference_uniquename":"PMID:29761456"}],"product":"Hexaprenyl pyrophosphate synthetase; catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000207","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR003W"}


id: YBR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00295":null,"YBR004C":null},"has_protein_features":false,"name":"GPI18","ortholog_annotations":[{"gene_uniquename":"YBR004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00295","reference_uniquename":"PMID:29761456"}],"product":"Functional ortholog of human PIG-V; PIG-V is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000208","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR004C"}


id: YBR005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01258":null,"YBR005W":null},"has_protein_features":false,"name":"RCR1","ortholog_annotations":[{"gene_uniquename":"YBR005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01258","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane (PM) ubiquitin ligase-substrate adaptor; involved in cell wall chitin deposition; ubiquitinates and down-regulates chitin synthase Chs3p abundance at PM via calcineurin/Crz1 signaling pathway which regulates RCR1 expression; delivered to PM by exomer complex using novel PM sorting motif; RCR1 has a paralog, RCR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000209","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR005W"}


id: YBR006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00674":null,"SJAG_03293":null,"YBR006W":null},"has_protein_features":false,"name":"UGA2","ortholog_annotations":[{"gene_uniquename":"YBR006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00674","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03293","reference_uniquename":"PMID:29761456"}],"product":"Succinate semialdehyde dehydrogenase; involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000210","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR006W"}


id: YBR007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01118":null,"YBR007C":null},"has_protein_features":false,"name":"DSF2","ortholog_annotations":[{"gene_uniquename":"YBR007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01118","reference_uniquename":"PMID:29761456"}],"product":"Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000211","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR007C"}


id: YBR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FLR1","product":"Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress","secondary_identifier":"SGD:S000000212","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR008C"}


id: YBR009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00303":null,"SJAG_00336":null,"SJAG_03542":null,"YBR009C":null},"has_protein_features":false,"name":"HHF1","ortholog_annotations":[{"gene_uniquename":"YBR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00303","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00336","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03542","reference_uniquename":"PMID:29761456"}],"product":"Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; involved in mRNA multiplexing; N-terminal domain involved in maintaining genomic integrity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000213","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR009C"}


id: YBR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00302":null,"SJAG_00335":null,"SJAG_03543":null,"YBR010W":null},"has_protein_features":false,"name":"HHT1","ortholog_annotations":[{"gene_uniquename":"YBR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00302","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00335","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03543","reference_uniquename":"PMID:29761456"}],"product":"Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000214","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR010W"}


id: YBR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02679":null,"YBR011C":null},"has_protein_features":false,"name":"IPP1","ortholog_annotations":[{"gene_uniquename":"YBR011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02679","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic inorganic pyrophosphatase (PPase); homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000215","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR011C"}


id: YBR012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; appears conserved and shows evidence of preservation by purifying selection within the Saccharomycotina subphylum; expression induced by iron-regulated transcriptional activator Aft2p","secondary_identifier":"SGD:S000000216","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR012C"}


id: YBR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein; SWAT-GFP fusion protein localizes to the endoplasmic reticulum while mCherry fusion protein localizes to both the endoplasmic reticulum and vacuole","secondary_identifier":"SGD:S000000217","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR013C"}


id: YBR014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02495":null,"YBR014C":null},"has_protein_features":false,"name":"GRX7","ortholog_annotations":[{"gene_uniquename":"YBR014C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02495","reference_uniquename":"PMID:29761456"}],"product":"Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000218","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR014C"}


id: YBR015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MNN2","product":"Alpha-1,2-mannosyltransferase; responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment","secondary_identifier":"SGD:S000000219","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR015C"}


id: YBR016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02333":null,"YBR016W":null},"has_protein_features":false,"name":"CPP1","ortholog_annotations":[{"gene_uniquename":"YBR016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02333","reference_uniquename":"PMID:29761456"}],"product":"Tail-anchored plasma membrane (PM) protein; C-terminal palmitoylation is required for membrane anchoring and protein stability; PM localization is polarized to the daughter cell; contains a conserved, cysteine-rich palmitoylated domain (CYSPD, aka CYSTM); similarity to hydrophilins, proteins involved in the adaptive response to hyperosmotic conditions; CPP1 has a paralog, YDL012C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000220","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR016W"}


id: YBR017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03959":null,"YBR017C":null},"has_protein_features":false,"name":"KAP104","ortholog_annotations":[{"gene_uniquename":"YBR017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03959","reference_uniquename":"PMID:29761456"}],"product":"Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR017C"}


id: YBR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02954":null,"YBR018C":null},"has_protein_features":false,"name":"GAL7","ortholog_annotations":[{"gene_uniquename":"YBR018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02954","reference_uniquename":"PMID:29761456"}],"product":"Galactose-1-phosphate uridyl transferase; synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism; human homolog UGP2 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000222","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR018C"}


id: YBR019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01784":null,"SJAG_02951":null,"SJAG_03818":null,"YBR019C":null},"has_protein_features":false,"name":"GAL10","ortholog_annotations":[{"gene_uniquename":"YBR019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01784","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02951","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03818","reference_uniquename":"PMID:29761456"}],"product":"UDP-glucose-4-epimerase; catalyzes interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers; human homolog GALE implicated in galactosemia, can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR019C"}


id: YBR020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02950":null,"YBR020W":null},"has_protein_features":false,"name":"GAL1","ortholog_annotations":[{"gene_uniquename":"YBR020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02950","reference_uniquename":"PMID:29761456"}],"product":"Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; human homolog GALK2 complements yeast null mutant; GAL1 has a paralog, GAL3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR020W"}


id: YBR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02147":null,"SJAG_04714":null,"YBR021W":null},"has_protein_features":false,"name":"FUR4","ortholog_annotations":[{"gene_uniquename":"YBR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02147","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YBR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04714","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000225","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR021W"}


id: YBR022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"POA1","product":"Phosphatase that is highly specific for ADP-ribose 1''-phosphate; a tRNA splicing metabolite; may have a role in regulation of tRNA splicing","secondary_identifier":"SGD:S000000226","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR022W"}


id: YBR023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CHS3","product":"Chitin synthase III; catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan; contains overlapping di-leucine and di-acidic signals that mediate, respectively, intracellular trafficking by AP-1 and trafficking to plasma membrane by exomer complex; requires AP-3 complex for its intracellular retention","secondary_identifier":"SGD:S000000227","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR023C"}


id: YBR024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04553":null,"YBR024W":null},"has_protein_features":false,"name":"SCO2","ortholog_annotations":[{"gene_uniquename":"YBR024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04553","reference_uniquename":"PMID:29761456"}],"product":"Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000228","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR024W"}


id: YBR025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04874":null,"YBR025C":null},"has_protein_features":false,"name":"OLA1","ortholog_annotations":[{"gene_uniquename":"YBR025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04874","reference_uniquename":"PMID:29761456"}],"product":"P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; positively regulates heat shock response; null mutant displays increased translation rate and increased readthrough of premature stop codons; protein abundance increases in response to hydrogen peroxide and to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000229","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR025C"}


id: YBR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02007":null,"YBR026C":null},"has_protein_features":false,"name":"ETR1","ortholog_annotations":[{"gene_uniquename":"YBR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02007","reference_uniquename":"PMID:29761456"}],"product":"2-enoyl thioester reductase; member of the medium chain dehydrogenase/reductase family; localized to mitochondria, where it has a probable role in fatty acid synthesis; human MECR functionally complements the respiratory growth defect of the null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR026C"}


id: YBR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YBR027C is not an essential gene","secondary_identifier":"SGD:S000000231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR027C"}


id: YBR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01047":null,"YBR028C":null},"has_protein_features":false,"name":"YPK3","ortholog_annotations":[{"gene_uniquename":"YBR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01047","reference_uniquename":"PMID:29761456"}],"product":"AGC kinase; phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner; directly phosphorylated by TORC1; phosphorylates ribosomal protein Rps6a/b (S6), in a TORC-dependent manner; undergoes autophosphorylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR028C"}


id: YBR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00426":null,"YBR029C":null},"has_protein_features":false,"name":"CDS1","ortholog_annotations":[{"gene_uniquename":"YBR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00426","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids; human homolog CDS1 can complement yeast cds1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR029C"}


id: YBR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01482":null,"YBR030W":null},"has_protein_features":false,"name":"RKM3","ortholog_annotations":[{"gene_uniquename":"YBR030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01482","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR030W"}


id: YBR031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06612":null,"YBR031W":null},"has_protein_features":false,"name":"RPL4A","ortholog_annotations":[{"gene_uniquename":"YBR031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06612","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR031W"}


id: YBR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YBR032W is not an essential gene","secondary_identifier":"SGD:S000000236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR032W"}


id: YBR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01930":null,"YBR033W":null},"has_protein_features":false,"name":"EDS1","ortholog_annotations":[{"gene_uniquename":"YBR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01930","reference_uniquename":"PMID:29761456"}],"product":"Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR033W"}


id: YBR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02756":null,"YBR034C":null},"has_protein_features":false,"name":"HMT1","ortholog_annotations":[{"gene_uniquename":"YBR034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02756","reference_uniquename":"PMID:29761456"}],"product":"Nuclear SAM-dependent mono- and asymmetric methyltransferase; modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p, ribosomal protein Rps2p, and histones H3 and H4; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR034C"}


id: YBR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01881":null,"YBR035C":null},"has_protein_features":false,"name":"PDX3","ortholog_annotations":[{"gene_uniquename":"YBR035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01881","reference_uniquename":"PMID:29761456"}],"product":"Pyridoxine (pyridoxamine) phosphate oxidase; has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR035C"}


id: YBR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSG2","product":"Calcium release channel involved in ER calcium homeostasis; integrates ER calcium release with the regulation of sphingolipid metabolism and autophagy; required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; endoplasmic reticulum membrane protein; contains 10 transmembrane domains and a potential Ca2+ EF-hand motif; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000000240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR036C"}


id: YBR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04553":null,"YBR037C":null},"has_protein_features":false,"name":"SCO1","ortholog_annotations":[{"gene_uniquename":"YBR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04553","reference_uniquename":"PMID:29761456"}],"product":"Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR037C"}


id: YBR038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00442":null,"SJAG_04868":null,"YBR038W":null},"has_protein_features":false,"name":"CHS2","ortholog_annotations":[{"gene_uniquename":"YBR038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00442","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04868","reference_uniquename":"PMID:29761456"}],"product":"Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR038W"}


id: YBR039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00438":null,"YBR039W":null},"has_protein_features":false,"name":"ATP3","ortholog_annotations":[{"gene_uniquename":"YBR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00438","reference_uniquename":"PMID:29761456"}],"product":"Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR039W"}


id: YBR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02351":null,"SJAG_02924":null,"YBR040W":null},"has_protein_features":false,"name":"FIG1","ortholog_annotations":[{"gene_uniquename":"YBR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02351","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02924","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR040W"}


id: YBR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FAT1","product":"Very long chain fatty acyl-CoA synthetase and fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids","secondary_identifier":"SGD:S000000245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR041W"}


id: YBR042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03935":null,"YBR042C":null},"has_protein_features":false,"name":"CST26","ortholog_annotations":[{"gene_uniquename":"YBR042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03935","reference_uniquename":"PMID:29761456"}],"product":"Acyltransferase; enzyme mainly responsible for the introduction of saturated very long chain fatty acids into neo-synthesized molecules of phosphatidylinositol; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR042C"}


id: YBR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"QDR3","product":"Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; involved in spore wall asembly; sequence similarity to DTR1 and QDR1, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin","secondary_identifier":"SGD:S000000247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR043C"}


id: YBR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TCM62","product":"Protein involved in assembly of the succinate dehydrogenase complex; mitochondrial; putative chaperone","secondary_identifier":"SGD:S000000248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR044C"}


id: YBR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GIP1","product":"Meiosis-specific regulatory subunit of the Glc7p protein phosphatase; regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p","secondary_identifier":"SGD:S000000249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR045C"}


id: YBR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03476":null,"YBR046C":null},"has_protein_features":false,"name":"ZTA1","ortholog_annotations":[{"gene_uniquename":"YBR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03476","reference_uniquename":"PMID:29761456"}],"product":"NADPH-dependent quinone reductase; GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR046C"}


id: YBR047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMP23","product":"Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000000251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR047W"}


id: YBR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00069":null,"SJAG_00503":null,"YBR048W":null},"has_protein_features":false,"name":"RPS11B","ortholog_annotations":[{"gene_uniquename":"YBR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00069","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00503","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR048W"}


id: YBR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00073":null,"SJAG_02922":null,"SJAG_04855":null,"YBR049C":null},"has_protein_features":false,"name":"REB1","ortholog_annotations":[{"gene_uniquename":"YBR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00073","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02922","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04855","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; Reb1p bound to DNA acts to block RNA polymerase II readthrough transcription","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR049C"}


id: YBR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"REG2","product":"Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease; REG2 has a paralog, REG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR050C"}


id: YBR051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase","secondary_identifier":"SGD:S000000255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR051W"}


id: YBR052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02697":null,"YBR052C":null},"has_protein_features":false,"name":"RFS1","ortholog_annotations":[{"gene_uniquename":"YBR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02697","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR052C"}


id: YBR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; induced by cell wall perturbation","secondary_identifier":"SGD:S000000257","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR053C"}


id: YBR054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02533":null,"YBR054W":null},"has_protein_features":false,"name":"YRO2","ortholog_annotations":[{"gene_uniquename":"YBR054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02533","reference_uniquename":"PMID:29761456"}],"product":"Protein with a putative role in response to acid stress; null mutant is sensitive to acetic acid; transcription is regulated by Haa1p and induced in the presence of acetic acid; protein observed in plasma membrane foci in the presence of acetic acid; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000258","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR054W"}


id: YBR055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00643":null,"YBR055C":null},"has_protein_features":false,"name":"PRP6","ortholog_annotations":[{"gene_uniquename":"YBR055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00643","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor; component of the U4/U6-U5 snRNP complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000259","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR055C"}


id: YBR056C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the dubious ORF YBR056W-A","secondary_identifier":"SGD:S000087087","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR056C-B"}


id: YBR056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03646":null,"YBR056W":null},"has_protein_features":false,"name":"MRX18","ortholog_annotations":[{"gene_uniquename":"YBR056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03646","reference_uniquename":"PMID:29761456"}],"product":"Putative glycoside hydrolase of the mitochondrial intermembrane space","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000260","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR056W"}


id: YBR056W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MNC1","product":"Putative membrane protein; upregulated by toxic concentrations of heavy metal ions including Mn2+, Co2+, Ni2+, Cu2+, and Zn2+; mRNA identified as translated by ribosome profiling data; localizes to the cytoplasm, possibly in intracellular membranes; CYSTM (cysteine-rich transmembrane module) family member; partially overlaps dubious ORF YBR056C-B; YBR056W-A has a paralog, YDR034W-B, that arose from the whole genome duplication","secondary_identifier":"SGD:S000028736","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR056W-A"}


id: YBR057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MUM2","product":"Protein essential for meiotic DNA replication and sporulation; cytoplasmic protein; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation; also interacts with Orc2p, which is a component of the origin recognition complex","secondary_identifier":"SGD:S000000261","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR057C"}


id: YBR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00644":null,"YBR058C":null},"has_protein_features":false,"name":"UBP14","ortholog_annotations":[{"gene_uniquename":"YBR058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00644","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-specific protease; specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000262","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR058C"}


id: YBR058C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01857":null,"YBR058C-A":null},"has_protein_features":false,"name":"TSC3","ortholog_annotations":[{"gene_uniquename":"YBR058C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01857","reference_uniquename":"PMID:29761456"}],"product":"Protein that stimulates the activity of serine palmitoyltransferase;  involved in sphingolipid biosynthesis; Lcb1p and Lcb2p are the two components of serine palmitoyltransferase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR058C-A"}


id: YBR059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00649":null,"SJAG_04052":null,"SJAG_04465":null,"YBR059C":null},"has_protein_features":false,"name":"AKL1","ortholog_annotations":[{"gene_uniquename":"YBR059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00649","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04052","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04465","reference_uniquename":"PMID:29761456"}],"product":"Ser/Thr protein kinase; phosphorylates Pan1p, Sla1p and Ent1p to negatively regulate endocytosis in response to membrane stress; regulates actin cytoskeleton organization and clathrin-dependent endocytosis; phosphorylated and inhibited by upstream kinase, Fpk1p; member, along with Ark1p and Prk1p, of the Ark kinase family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000263","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR059C"}


id: YBR060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02800":null,"YBR060C":null},"has_protein_features":false,"name":"ORC2","ortholog_annotations":[{"gene_uniquename":"YBR060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02800","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000264","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR060C"}


id: YBR061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01269":null,"YBR061C":null},"has_protein_features":false,"name":"TRM7","ortholog_annotations":[{"gene_uniquename":"YBR061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01269","reference_uniquename":"PMID:29761456"}],"product":"2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively; yeast null mutant can be functionally complemented by human FTSJ1, mutations in which have been implicated in nonsyndromic X-linked intellectual disability (NSXLID)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000265","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR061C"}


id: YBR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01507":null,"SJAG_04915":null,"YBR062C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBR062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01507","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04915","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000266","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR062C"}


id: YBR063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CNM1","product":"Molecular tether on nuclear membrane; mediates contact by interacting with Tom70p on mitochondria; protein abundance is regulated by phosphatidylcholine, enabling coupling of phospholipid homeostasis with contact extent","secondary_identifier":"SGD:S000000267","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR063C"}


id: YBR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR063C","secondary_identifier":"SGD:S000000268","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR064W"}


id: YBR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04117":null,"YBR065C":null},"has_protein_features":false,"name":"ECM2","ortholog_annotations":[{"gene_uniquename":"YBR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04117","reference_uniquename":"PMID:29761456"}],"product":"Pre-mRNA splicing factor; facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000269","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR065C"}


id: YBR066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00124":null,"YBR066C":null},"has_protein_features":false,"name":"NRG2","ortholog_annotations":[{"gene_uniquename":"YBR066C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00124","reference_uniquename":"PMID:26896847"}],"product":"Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; activated in stochastic pulses of nuclear localization in response to low glucose","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000000270","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR066C"}


id: YBR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TIP1","product":"Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins","secondary_identifier":"SGD:S000000271","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR067C"}


id: YBR068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YBR068C":null},"has_protein_features":false,"name":"BAP2","ortholog_annotations":[{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000272","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR068C"}


id: YBR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YBR069C":null},"has_protein_features":false,"name":"TAT1","ortholog_annotations":[{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000273","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR069C"}


id: YBR070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04821":null,"YBR070C":null},"has_protein_features":false,"name":"ALG14","ortholog_annotations":[{"gene_uniquename":"YBR070C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04821","reference_uniquename":"PMID:29761456"}],"product":"Component of UDP-GlcNAc transferase; required for second step of dolichyl-linked oligosaccharide synthesis; anchors catalytic subunit Alg13p to ER membrane; localizes to the peroxisome; similar to bacterial and human glycosyltransferases; both human homologs ALG13 and ALG14 are required to complement yeast alg14 mutant; mutations of human ALG14 cause congenital myasthenic syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000274","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR070C"}


id: YBR071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking","secondary_identifier":"SGD:S000000275","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR071W"}


id: YBR072C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by fungal homology and RT-PCR;  localizes to cytosol and peroxisomes","secondary_identifier":"SGD:S000028532","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR072C-A"}


id: YBR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02919":null,"SJAG_03815":null,"SJAG_04567":null,"YBR072W":null},"has_protein_features":false,"name":"HSP26","ortholog_annotations":[{"gene_uniquename":"YBR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02919","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03815","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04567","reference_uniquename":"PMID:29761456"}],"product":"Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic foci; oligomer activation requires heat-induced conformational change; also has mRNA binding activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000276","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR072W"}


id: YBR073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00980":null,"YBR073W":null},"has_protein_features":false,"name":"RDH54","ortholog_annotations":[{"gene_uniquename":"YBR073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00980","reference_uniquename":"PMID:29761456"}],"product":"DNA-dependent ATPase; DNA recombination/repair translocase, supercoils DNA, promotes DNA strand opening; stimulates strand exchange by modifying dsDNA topology; involved in recombinational repair of DNA double-strand breaks (DSBs) during mitosis, meiosis; implicated in cell divisions in telomerase-negative strains through adaptation to DNA damage, which allows bypass of cell cycle arrest and contributes senescence-specific genome instability; phosphorylated in response to DNA damage","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000277","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR073W"}


id: YBR074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03009":null,"SJAG_04103":null,"YBR074W":null},"has_protein_features":false,"name":"PFF1","ortholog_annotations":[{"gene_uniquename":"YBR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03009","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04103","reference_uniquename":"PMID:29761456"}],"product":"Multi-spanning vacuolar membrane protease; glycosylated transmembrane protein bearing homology to M28 family of metalloproteases; has lumenal-facing protease domain; proposed role in vacuole physiology; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000278","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR074W"}


id: YBR075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YBR075W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YBR074W","secondary_identifier":"SGD:S000000279","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR075W"}


id: YBR076C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028533","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR076C-A"}


id: YBR076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05002":null,"YBR076W":null},"has_protein_features":false,"name":"ECM8","ortholog_annotations":[{"gene_uniquename":"YBR076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05002","reference_uniquename":"PMID:29761456"}],"product":"Non-essential protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000280","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR076W"}


id: YBR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03089":null,"YBR077C":null},"has_protein_features":false,"name":"SLM4","ortholog_annotations":[{"gene_uniquename":"YBR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03089","reference_uniquename":"PMID:29761456"}],"product":"Subunit of EGO/GSE complex; vacuolar/endosomal membrane-associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from endosome to plasma membrane; essential for integrity and function of EGO; targeted to vacuole via AP-3 pathway; gene exhibits synthetic genetic interaction with MSS4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000281","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR077C"}


id: YBR078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00340":null,"SJAG_03483":null,"YBR078W":null},"has_protein_features":false,"name":"ECM33","ortholog_annotations":[{"gene_uniquename":"YBR078W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00340","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR078W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03483","reference_uniquename":"PMID:29761456"}],"product":"GPI-anchored protein involved in efficient glucose uptake; possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p; ECM33 has a paralog, PST1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000282","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR078W"}


id: YBR079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02628":null,"YBR079C":null},"has_protein_features":false,"name":"RPG1","ortholog_annotations":[{"gene_uniquename":"YBR079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02628","reference_uniquename":"PMID:29761456"}],"product":"eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; essential for loading mRNA onto ribosome at entry and exit channels of preinitiation complex; involved in translation reinitiation; eIF3 is also involved in programmed stop codon readthrough","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000283","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR079C"}


id: YBR080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00330":null,"YBR080C":null},"has_protein_features":false,"name":"SEC18","ortholog_annotations":[{"gene_uniquename":"YBR080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00330","reference_uniquename":"PMID:29761456"}],"product":"AAA ATPase and SNARE disassembly chaperone; required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian N-ethylmaleimide-sensitive factor (NSF)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000284","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR080C"}


id: YBR081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02927":null,"YBR081C":null},"has_protein_features":false,"name":"SPT7","ortholog_annotations":[{"gene_uniquename":"YBR081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02927","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SAGA transcriptional regulatory complex; involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000285","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR081C"}


id: YBR082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04573":null,"YBR082C":null},"has_protein_features":false,"name":"UBC4","ortholog_annotations":[{"gene_uniquename":"YBR082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04573","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-conjugating enzyme (E2); key E2 partner with Ubc1p for the anaphase-promoting complex (APC); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000286","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR082C"}


id: YBR083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TEC1","product":"Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member","secondary_identifier":"SGD:S000000287","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR083W"}


id: YBR084C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00384":null,"SJAG_00765":null,"YBR084C-A":null},"has_protein_features":false,"name":"RPL19A","ortholog_annotations":[{"gene_uniquename":"YBR084C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00384","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR084C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00765","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002156","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR084C-A"}


id: YBR084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00106":null,"SJAG_04156":null,"YBR084W":null},"has_protein_features":false,"name":"MIS1","ortholog_annotations":[{"gene_uniquename":"YBR084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00106","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04156","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial C1-tetrahydrofolate synthase; involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000288","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR084W"}


id: YBR085C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000007522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR085C-A"}


id: YBR085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02050":null,"YBR085W":null},"has_protein_features":false,"name":"AAC3","ortholog_annotations":[{"gene_uniquename":"YBR085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02050","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000289","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR085W"}


id: YBR086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01168":null,"YBR086C":null},"has_protein_features":false,"name":"IST2","ortholog_annotations":[{"gene_uniquename":"YBR086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01168","reference_uniquename":"PMID:29761456"}],"product":"Cortical ER protein involved in ER-plasma membrane (PM) tethering; one of 6 proteins (Ist2, Scs2, Scs22, Tcb1, Tcb2, Tcb3) that connect ER to PM, regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1 phosphatase to PI4P; required to locate Osh6, Osh7 in ER/PM contact site to allow phosphatidylserine transport from ER to PM; localizes to mother in small-budded cells, to bud in medium-, large-budded cells; mRNA transported to bud tip by actomyosin-driven process","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000290","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR086C"}


id: YBR087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00272":null,"YBR087W":null},"has_protein_features":false,"name":"RFC5","ortholog_annotations":[{"gene_uniquename":"YBR087W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00272","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000291","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR087W"}


id: YBR088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04190":null,"YBR088C":null},"has_protein_features":false,"name":"POL30","ortholog_annotations":[{"gene_uniquename":"YBR088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04190","reference_uniquename":"PMID:29761456"}],"product":"Proliferating cell nuclear antigen (PCNA); functions as the sliding replication clamp for DNA polymerase δ; may function as docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair; PCNA ubiquitination at K164 plays crucial role during Okazaki fragment processing; Leu164 is essential for stable complex formation with replicative DNA polymerase δ","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000292","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR088C"}


id: YBR089C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03603":null,"YBR089C-A":null},"has_protein_features":false,"name":"NHP6B","ortholog_annotations":[{"gene_uniquename":"YBR089C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03603","reference_uniquename":"PMID:29761456"}],"product":"High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002157","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR089C-A"}


id: YBR089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30","secondary_identifier":"SGD:S000000293","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR089W"}


id: YBR090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus","secondary_identifier":"SGD:S000000294","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR090C"}


id: YBR091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00687":null,"YBR091C":null},"has_protein_features":false,"name":"TIM12","ortholog_annotations":[{"gene_uniquename":"YBR091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00687","reference_uniquename":"PMID:29761456"}],"product":"Essential protein of the inner mitochondrial membrane; peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000295","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR091C"}


id: YBR092C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01970":null,"SJAG_04067":null,"YBR092C":null},"has_protein_features":false,"name":"PHO3","ortholog_annotations":[{"gene_uniquename":"YBR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01970","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04067","reference_uniquename":"PMID:29761456"}],"product":"Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000296","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR092C"}


id: YBR093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01970":null,"SJAG_04067":null,"YBR093C":null},"has_protein_features":false,"name":"PHO5","ortholog_annotations":[{"gene_uniquename":"YBR093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01970","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04067","reference_uniquename":"PMID:29761456"}],"product":"Repressible acid phosphatase; 1 of 3 repressible acid phosphatases that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000297","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR093C"}


id: YBR094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01897":null,"YBR094W":null},"has_protein_features":false,"name":"PBY1","ortholog_annotations":[{"gene_uniquename":"YBR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01897","reference_uniquename":"PMID:29761456"}],"product":"Putative tubulin tyrosine ligase associated with P-bodies; may have a role in mRNA metabolism; yeast knockout collection strain identified as a pby1 null mutant is actually wild-type for PBY1 and deleted for mms4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000298","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR094W"}


id: YBR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04576":null,"YBR095C":null},"has_protein_features":false,"name":"RXT2","ortholog_annotations":[{"gene_uniquename":"YBR095C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04576","reference_uniquename":"PMID:29761456"}],"product":"Component of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000299","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR095C"}


id: YBR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER","secondary_identifier":"SGD:S000000300","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR096W"}


id: YBR097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04552":null,"YBR097W":null},"has_protein_features":false,"name":"VPS15","ortholog_annotations":[{"gene_uniquename":"YBR097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04552","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000301","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR097W"}


id: YBR098W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00623":null,"YBR098W":null},"has_protein_features":false,"name":"MMS4","ortholog_annotations":[{"gene_uniquename":"YBR098W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00623","reference_uniquename":"PMID:29761456"}],"product":"Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdc5p during mitotic cell cycle activates the function of Mms4p-Mus81p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000302","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR098W"}


id: YBR099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4","secondary_identifier":"SGD:S000000303","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR099C"}


id: YBR100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YBR100W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YBR098W","secondary_identifier":"SGD:S000000304","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR100W"}


id: YBR101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01556":null,"YBR101C":null},"has_protein_features":false,"name":"FES1","ortholog_annotations":[{"gene_uniquename":"YBR101C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01556","reference_uniquename":"PMID:29761456"}],"product":"Hsp70 (Ssa1p) nucleotide exchange factor; required for the release of misfolded proteins from the Hsp70 system to the Ub-proteasome machinery for degradation; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000305","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR101C"}


id: YBR102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03357":null,"YBR102C":null},"has_protein_features":false,"name":"EXO84","ortholog_annotations":[{"gene_uniquename":"YBR102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03357","reference_uniquename":"PMID:29761456"}],"product":"Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting of the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000306","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR102C"}


id: YBR103C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by homology to related yeast","secondary_identifier":"SGD:S000007593","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR103C-A"}


id: YBR103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01926":null,"YBR103W":null},"has_protein_features":false,"name":"SIF2","ortholog_annotations":[{"gene_uniquename":"YBR103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01926","reference_uniquename":"PMID:29761456"}],"product":"WD40 repeat-containing subunit of Set3C histone deacetylase complex; complex represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000307","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR103W"}


id: YBR104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00626":null,"YBR104W":null},"has_protein_features":false,"name":"YMC2","ortholog_annotations":[{"gene_uniquename":"YBR104W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00626","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000308","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR104W"}


id: YBR105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03385":null,"YBR105C":null},"has_protein_features":false,"name":"VID24","ortholog_annotations":[{"gene_uniquename":"YBR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03385","reference_uniquename":"PMID:29761456"}],"product":"GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000309","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR105C"}


id: YBR106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00603":null,"SJAG_01782":null,"YBR106W":null},"has_protein_features":false,"name":"SND3","ortholog_annotations":[{"gene_uniquename":"YBR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00603","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01782","reference_uniquename":"PMID:29761456"}],"product":"Involved in SRP-independent protein targeting to the ER; component of an alternative ER-targeting pathway partially redundant with the GET pathway that can compensate for SRP loss; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Env10p/Snd2p, and Sec61p-translocon subunits; role in establishing nucleus-vacuole junctions (NVJs) in high glucose; targeted to the NVJ during glucose starvation to facilitate expansion; role in phosphate transport with Pho86p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000310","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR106W"}


id: YBR107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01278":null,"YBR107C":null},"has_protein_features":false,"name":"IML3","ortholog_annotations":[{"gene_uniquename":"YBR107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01278","reference_uniquename":"PMID:29761456"}],"product":"Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; forms a stable complex with Chl4p; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000311","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR107C"}


id: YBR108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM3","product":"Protein that inhibits barbed-end actin filament elongation; interacts with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss","secondary_identifier":"SGD:S000000312","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR108W"}


id: YBR109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04781":null,"SJAG_04901":null,"YBR109C":null},"has_protein_features":false,"name":"CMD1","ortholog_annotations":[{"gene_uniquename":"YBR109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04781","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YBR109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04901","reference_uniquename":"PMID:29761456"}],"product":"Calmodulin; Ca2+ binding protein that regulates Ca2+ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca2+ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin; binds to the Hog1p MAPK in response to hyperosmotic stress; potentiates membrane tubulation and constriction mediated by the Rvs161p-Rvs167p complex; human CALM1 or CALM2 functionally complement repression induced inviability","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000313","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR109C"}


id: YBR109W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; questionable ORF from MIPS","secondary_identifier":"SGD:S000028737","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR109W-A"}


id: YBR110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02102":null,"YBR110W":null},"has_protein_features":false,"name":"ALG1","ortholog_annotations":[{"gene_uniquename":"YBR110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02102","reference_uniquename":"PMID:29761456"}],"product":"Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability; human homolog ALG1 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000314","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR110W"}


id: YBR111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03977":null,"YBR111C":null},"has_protein_features":false,"name":"YSA1","ortholog_annotations":[{"gene_uniquename":"YBR111C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03977","reference_uniquename":"PMID:29761456"}],"product":"Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000315","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR111C"}


id: YBR111W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00641":null,"YBR111W-A":null},"has_protein_features":false,"name":"SUS1","ortholog_annotations":[{"gene_uniquename":"YBR111W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00641","reference_uniquename":"PMID:29761456"}],"product":"Global transcriptional regulator, component of SAGA, TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to nuclear periphery and to non-nascent mRNP; plays role in negatively regulating telomere length through modulation of H2BK123 mono-ubiquitination and its interaction with nuclear pore complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028510","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR111W-A"}


id: YBR112C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00861":null,"YBR112C":null},"has_protein_features":false,"name":"CYC8","ortholog_annotations":[{"gene_uniquename":"YBR112C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00861","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional regulator; functions primarily as a transcriptional co-repressor with Tup1p but can also function as a transcriptional co-activator with Tup1p that recruits the SWI/SNF and SAGA complexes to promoters; target genes may be uniquely repressed by Cyc8p or Tup1p, subject to redundant repression, or in some cases de-repression of target genes in a cyc8 mutant is dependent upon TUP1 and vice versa; can form the prion [OCT+]","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000316","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR112C"}


id: YBR113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8","secondary_identifier":"SGD:S000000317","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR113W"}


id: YBR114W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00500":null,"SJAG_03613":null,"SJAG_04147":null,"YBR114W":null},"has_protein_features":false,"name":"RAD16","ortholog_annotations":[{"gene_uniquename":"YBR114W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00500","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR114W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03613","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR114W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04147","reference_uniquename":"PMID:29761456"}],"product":"Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad7p) during NER; required for NER of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000318","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR114W"}


id: YBR115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00869":null,"YBR115C":null},"has_protein_features":false,"name":"LYS2","ortholog_annotations":[{"gene_uniquename":"YBR115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00869","reference_uniquename":"PMID:29761456"}],"product":"Alpha aminoadipate reductase; catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000319","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR115C"}


id: YBR116C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2","secondary_identifier":"SGD:S000000320","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR116C"}


id: YBR117C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03934":null,"YBR117C":null},"has_protein_features":false,"name":"TKL2","ortholog_annotations":[{"gene_uniquename":"YBR117C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03934","reference_uniquename":"PMID:29761456"}],"product":"Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL2 has a paralog, TKL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000321","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR117C"}


id: YBR118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01851":null,"SJAG_02180":null,"SJAG_04157":null,"YBR118W":null},"has_protein_features":false,"name":"TEF2","ortholog_annotations":[{"gene_uniquename":"YBR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01851","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02180","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04157","reference_uniquename":"PMID:29761456"}],"product":"Translational elongation factor EF-1 alpha; GTP-bound active form, binds to and delivers aminoacylated tRNA to the A-site of ribosomes for elongation of nascent polypeptides; moonlighting function as an actin binding and bundling protein; association with GTPase Rho1p on the vacuolar membrane may facilitate F-actin remodeling; involved in tRNA re-export from the nucleus; Tef2p-RFP levels increase during replicative aging","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000322","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR118W"}


id: YBR119W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04911":null,"YBR119W":null},"has_protein_features":false,"name":"MUD1","ortholog_annotations":[{"gene_uniquename":"YBR119W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04911","reference_uniquename":"PMID:29761456"}],"product":"U1 snRNP A protein; homolog of human U1-A; involved in nuclear mRNA splicing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000323","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR119W"}


id: YBR120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04560":null,"YBR120C":null},"has_protein_features":false,"name":"CBP6","ortholog_annotations":[{"gene_uniquename":"YBR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04560","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000324","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR120C"}


id: YBR121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01352":null,"YBR121C":null},"has_protein_features":false,"name":"GRS1","ortholog_annotations":[{"gene_uniquename":"YBR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01352","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication; human homolog GARS implicated in Charcot-Marie-Tooth disease, can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000325","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR121C"}


id: YBR121C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely contained within the verified gene GRS1; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028815","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR121C-A"}


id: YBR122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05573":null,"YBR122C":null},"has_protein_features":false,"name":"MRPL36","ortholog_annotations":[{"gene_uniquename":"YBR122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05573","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000326","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR122C"}


id: YBR123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03354":null,"YBR123C":null},"has_protein_features":false,"name":"TFC1","ortholog_annotations":[{"gene_uniquename":"YBR123C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03354","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000327","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR123C"}


id: YBR124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000000328","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR124W"}


id: YBR125C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PTC4","product":"Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity","secondary_identifier":"SGD:S000000329","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR125C"}


id: YBR126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01531":null,"YBR126C":null},"has_protein_features":false,"name":"TPS1","ortholog_annotations":[{"gene_uniquename":"YBR126C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01531","reference_uniquename":"PMID:29761456"}],"product":"Synthase subunit of trehalose-6-P synthase/phosphatase complex; synthesizes the storage carbohydrate trehalose, which is critically important for survival of long-term desiccation; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid; required for pseudohyphal growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000330","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR126C"}


id: YBR126W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MEO1","product":"Putative protein of unknown function; identified by gene-trapping, microarray analysis, and genome-wide homology searches; mRNA identified as translated by ribosome profiling data; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; partially overlaps the dubious ORF YBR126W-B","secondary_identifier":"SGD:S000028600","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR126W-A"}


id: YBR126W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-A; identified by SAGE","secondary_identifier":"SGD:S000028738","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR126W-B"}


id: YBR127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00136":null,"YBR127C":null},"has_protein_features":false,"name":"VMA2","ortholog_annotations":[{"gene_uniquename":"YBR127C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00136","reference_uniquename":"PMID:29761456"}],"product":"Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase; electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm; protein abundance increases in response to DNA replication stress; human homolog ATP6V1B1, implicated in autosomal-recessive distal renal tubular acidosis (RTA) with sensorineural deafness, complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000331","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR127C"}


id: YBR128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02699":null,"YBR128C":null},"has_protein_features":false,"name":"ATG14","ortholog_annotations":[{"gene_uniquename":"YBR128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02699","reference_uniquename":"PMID:29761456"}],"product":"Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I; Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor; other members are Vps34, Vps15, and Vps30p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000332","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR128C"}


id: YBR129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02657":null,"YBR129C":null},"has_protein_features":false,"name":"OPY1","ortholog_annotations":[{"gene_uniquename":"YBR129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02657","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000333","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR129C"}


id: YBR130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SHE3","product":"Protein adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance","secondary_identifier":"SGD:S000000334","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR130C"}


id: YBR131C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR131W; identified by gene-trapping, microarray analysis, and genome-wide homology searches","secondary_identifier":"SGD:S000028601","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR131C-A"}


id: YBR131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CCZ1","product":"Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex, which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; involved in localizing Ypt7p to the vacuolar membrane; required for macroautophagy, the CVT pathway and mitophagy","secondary_identifier":"SGD:S000000335","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR131W"}


id: YBR132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02955":null,"YBR132C":null},"has_protein_features":false,"name":"AGP2","ortholog_annotations":[{"gene_uniquename":"YBR132C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02955","reference_uniquename":"PMID:26896847"}],"product":"Plasma membrane regulator of high affinity polyamine and carnitine transport; has similarity to transporters but lacks transport activity; may act as a sensor that transduces environmental signals; has a positive or negative regulatory effect on transcription of many transporter genes; null mutant is cycloheximide (CHX) resistant; ubiquitinated Agp2p is rapidly degraded in a Brp1p-dependent manner in the presence of CHX; localizes to the plasma membrane, the vacuolar membrane and the ER membrane","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000000336","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR132C"}


id: YBR133C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00596":null,"YBR133C":null},"has_protein_features":false,"name":"HSL7","ortholog_annotations":[{"gene_uniquename":"YBR133C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00596","reference_uniquename":"PMID:29761456"}],"product":"Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent localization to the bud neck in budded cells and periodic Hsl1p-dependent phosphorylation; required with Hsl1p, and Elm1p for the mother-bud neck recruitment, phosphorylation, and degradation of Swe1p; responsible for symmetric dimethylation of histone H4 on Arg3; relocalizes away from bud neck upon DNA replication stress; human homolog PRMT5 can complement yeast hsl7 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000337","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR133C"}


id: YBR134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000338","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR134W"}


id: YBR135W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00439":null,"YBR135W":null},"has_protein_features":false,"name":"CKS1","ortholog_annotations":[{"gene_uniquename":"YBR135W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00439","reference_uniquename":"PMID:29761456"}],"product":"Cyclin-dependent protein kinase regulatory subunit and adaptor; interacts with Cdc28p (aka Cdk1p); required for G1/S and G2/M phase transitions and budding; mediates phosphorylation and degradation of Sic1p; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters; human homologs CKS1B and CKS2 can each complement yeast cks1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000339","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR135W"}


id: YBR136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00364":null,"YBR136W":null},"has_protein_features":false,"name":"MEC1","ortholog_annotations":[{"gene_uniquename":"YBR136W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00364","reference_uniquename":"PMID:29761456"}],"product":"Genome integrity checkpoint protein and PI kinase superfamily member; Mec1p and Dun1p function in same pathway to regulate dNTP pools and telomere length; signal transducer required for cell cycle arrest and transcriptional responses to damaged or unreplicated DNA; facilitates replication fork progression and regulates P-body formation under replication stress; promotes interhomolog recombination by phosphorylating Hop1p; associates with shortened, dysfunctional telomeres","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000340","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR136W"}


id: YBR137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein with a role in ER delivery of tail-anchored membrane proteins; interacts with Sgt2p; binds to the TRC complex, which inserts proteins into the ER membrane; interacts with Msn5p karyopherin; YBR137W is not an essential gene","secondary_identifier":"SGD:S000000341","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR137W"}


id: YBR138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Cytoplasmic protein of unknown function; APCC(Cdh1) substrate; potentially phosphorylated by Cdc28p; YBR138C is not an essential gene","secondary_identifier":"SGD:S000000342","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR138C"}


id: YBR139W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01868":null,"YBR139W":null},"has_protein_features":false,"name":"ATG42","ortholog_annotations":[{"gene_uniquename":"YBR139W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01868","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar serine-type carboxypeptidase; involved, along with functional homolog Prc1p, in vacuolar zymogen activation, breakdown of the autophagic body, and autophagosome-dependent protein synthesis; role in phytochelatin synthesis; localizes to the vacuole lumen; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner; N-glycosylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000343","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR139W"}


id: YBR140C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRA1","product":"GTPase-activating protein; negatively regulates RAS by converting it from GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog, IRA2, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis","secondary_identifier":"SGD:S000000344","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR140C"}


id: YBR141C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03016":null,"YBR141C":null},"has_protein_features":false,"name":"BMT2","ortholog_annotations":[{"gene_uniquename":"YBR141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03016","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of large subunit (LSU) rRNA at position 2142; belongs to Rossmann fold superfamily; null mutant exhibits abnormal lipid metabolic phenotype; not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000345","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR141C"}


id: YBR141W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YBR141C; identified by gene-trapping, microarray analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028602","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR141W-A"}


id: YBR142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02835":null,"YBR142W":null},"has_protein_features":false,"name":"MAK5","ortholog_annotations":[{"gene_uniquename":"YBR142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02835","reference_uniquename":"PMID:29761456"}],"product":"Essential nucleolar protein; putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000346","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR142W"}


id: YBR143C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00338":null,"YBR143C":null},"has_protein_features":false,"name":"SUP45","ortholog_annotations":[{"gene_uniquename":"YBR143C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00338","reference_uniquename":"PMID:29761456"}],"product":"Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000347","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR143C"}


id: YBR144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; YBR144C is not an essential gene","secondary_identifier":"SGD:S000000348","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR144C"}


id: YBR145W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01414":null,"SJAG_03370":null,"YBR145W":null},"has_protein_features":false,"name":"ADH5","ortholog_annotations":[{"gene_uniquename":"YBR145W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01414","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR145W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03370","reference_uniquename":"PMID:29761456"}],"product":"Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000349","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR145W"}


id: YBR146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04753":null,"YBR146W":null},"has_protein_features":false,"name":"MRPS9","ortholog_annotations":[{"gene_uniquename":"YBR146W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04753","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000350","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR146W"}


id: YBR147W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00051":null,"SJAG_04787":null,"YBR147W":null},"has_protein_features":false,"name":"RTC2","ortholog_annotations":[{"gene_uniquename":"YBR147W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00051","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR147W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04787","reference_uniquename":"PMID:29761456"}],"product":"Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000351","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR147W"}


id: YBR148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YSW1","product":"Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane; YSW1 has a paralog, SPO21, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000352","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR148W"}


id: YBR149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ARA1","product":"NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product","secondary_identifier":"SGD:S000000353","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR149W"}


id: YBR150C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TBS1","product":"Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; associates with rDNA chromatin in vivo; TBS1 has a paralog, HAL9, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000354","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR150C"}


id: YBR151W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"APD1","product":"2Fe-2S cytosolic protein of unknown function; bishistidinyl coordinated, non-Rieske [2Fe-2S] cluster containing thiredoxin-like ferredoxin; required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm; homologous to AIM32","secondary_identifier":"SGD:S000000355","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR151W"}


id: YBR152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00076":null,"YBR152W":null},"has_protein_features":false,"name":"SPP381","ortholog_annotations":[{"gene_uniquename":"YBR152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00076","reference_uniquename":"PMID:29761456"}],"product":"mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p; relocalizes to the cytosol in response to hypoxia; temperature-sensitive phenotype of prp38-1 mutant can be suppressed by human homolog of SPP381, MFAP1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000356","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR152W"}


id: YBR153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00491":null,"YBR153W":null},"has_protein_features":false,"name":"RIB7","ortholog_annotations":[{"gene_uniquename":"YBR153W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00491","reference_uniquename":"PMID:29761456"}],"product":"Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000357","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR153W"}


id: YBR154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02101":null,"YBR154C":null},"has_protein_features":false,"name":"RPB5","ortholog_annotations":[{"gene_uniquename":"YBR154C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02101","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000358","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR154C"}


id: YBR155W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01914":null,"YBR155W":null},"has_protein_features":false,"name":"CNS1","ortholog_annotations":[{"gene_uniquename":"YBR155W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01914","reference_uniquename":"PMID:29761456"}],"product":"TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70); stimulates ATPase activity of Ssa1p; ts mutants reduce Hsp82p function, overexpression suppresses phenotypes of HSP82 ts allele and cpr7 deletion; human homolog TTC4 complements yeast cns1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000359","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR155W"}


id: YBR156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02807":null,"YBR156C":null},"has_protein_features":false,"name":"SLI15","ortholog_annotations":[{"gene_uniquename":"YBR156C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02807","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the conserved chromosomal passenger complex (CPC); complex regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; other complex members are Ipl1p, Bir1p, and Nbl1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000360","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR156C"}


id: YBR157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ICS2","product":"Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization","secondary_identifier":"SGD:S000000361","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR157C"}


id: YBR158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AMN1","product":"Modulator of cell separation and mitotic exit; inhibits separation through Ub-dependent Ace2p proteolysis; part of a daughter-specific switch induced by the mitotic exit network that inhibits exit and resets the cell cycle after the execution of  MEN function, blocking Tem1p and Cdc15 association; required for chromosome stability and multiple mitotic checkpoints; regulated by SCF; haploid transcription regulated by Ste12p; contains 12 degenerate leucine-rich repeat motifs and an atypical F-box","secondary_identifier":"SGD:S000000362","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR158W"}


id: YBR159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00630":null,"YBR159W":null},"has_protein_features":false,"name":"IFA38","ortholog_annotations":[{"gene_uniquename":"YBR159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00630","reference_uniquename":"PMID:29761456"}],"product":"Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000363","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR159W"}


id: YBR160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03048":null,"YBR160W":null},"has_protein_features":false,"name":"CDC28","ortholog_annotations":[{"gene_uniquename":"YBR160W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03048","reference_uniquename":"PMID:29761456"}],"product":"Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1, S, G2/M phase cyclins, which provide substrate specificity; regulates metabolism, basal transcription, chromosome dynamics, growth and morphogenesis; transcript induction in osmostress involves antisense RNA; human homologs CDK1, CDK2, CDK3 can complement yeast conditional cdc28 mutants; human CDK1, CDK2 can complement yeast cdc28 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000364","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR160W"}


id: YBR161W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02168":null,"SJAG_03953":null,"YBR161W":null},"has_protein_features":false,"name":"CSH1","ortholog_annotations":[{"gene_uniquename":"YBR161W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02168","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR161W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03953","reference_uniquename":"PMID:29761456"}],"product":"Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000365","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR161W"}


id: YBR162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00876":null,"YBR162C":null},"has_protein_features":false,"name":"TOS1","ortholog_annotations":[{"gene_uniquename":"YBR162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00876","reference_uniquename":"PMID:29761456"}],"product":"Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000366","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR162C"}


id: YBR162W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03611":null,"YBR162W-A":null},"has_protein_features":false,"name":"YSY6","ortholog_annotations":[{"gene_uniquename":"YBR162W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03611","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002158","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR162W-A"}


id: YBR163W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05280":null,"YBR163W":null},"has_protein_features":false,"name":"EXO5","ortholog_annotations":[{"gene_uniquename":"YBR163W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05280","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial 5'-3' exonuclease and sliding exonuclease; required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000367","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR163W"}


id: YBR164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ARL1","product":"Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; role in membrane organization at trans-Golgi network; required for delivery of Atg9p to the phagophore assembly site during autophagy under high temperature stress; required with Ypt6p for starvation-induced autophagy; required for the CVT pathway under non-starvation conditions; G protein of the Ras superfamily, similar to ADP-ribosylation factor","secondary_identifier":"SGD:S000000368","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR164C"}


id: YBR165W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UBS1","product":"Ubiquitin-conjugating enzyme suppressor that regulates Cdc34p; functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity","secondary_identifier":"SGD:S000000369","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR165W"}


id: YBR166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04652":null,"YBR166C":null},"has_protein_features":false,"name":"TYR1","ortholog_annotations":[{"gene_uniquename":"YBR166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04652","reference_uniquename":"PMID:29761456"}],"product":"Prephenate dehydrogenase involved in tyrosine biosynthesis; expression is dependent on phenylalanine levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000370","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR166C"}


id: YBR167C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01369":null,"SJAG_06613":null,"YBR167C":null},"has_protein_features":false,"name":"POP7","ortholog_annotations":[{"gene_uniquename":"YBR167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01369","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06613","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop6p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000371","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR167C"}


id: YBR168W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01685":null,"YBR168W":null},"has_protein_features":false,"name":"PEX32","ortholog_annotations":[{"gene_uniquename":"YBR168W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01685","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000372","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR168W"}


id: YBR169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04511":null,"YBR169C":null},"has_protein_features":false,"name":"SSE2","ortholog_annotations":[{"gene_uniquename":"YBR169C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04511","reference_uniquename":"PMID:29761456"}],"product":"Member of Hsp110 subclass of the heat shock protein 70 (HSP70) family; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000373","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR169C"}


id: YBR170C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01134":null,"YBR170C":null},"has_protein_features":false,"name":"NPL4","ortholog_annotations":[{"gene_uniquename":"YBR170C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01134","reference_uniquename":"PMID:29761456"}],"product":"Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; K48-specific Ub chain binding receptor that assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates destined for proteasomal degradation; role in regulated destruction of ER membrane proteins, like HMG-CoA reductase (Hmg1/2p), cytosolic proteins (Fbp1p) and mislocalized proteins (Cse4p); mobilizes membrane-bound transcription factors by regulated Ub/proteasome-dependent processing; contains a UBX domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000374","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR170C"}


id: YBR171W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02354":null,"YBR171W":null},"has_protein_features":false,"name":"SEC66","ortholog_annotations":[{"gene_uniquename":"YBR171W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02354","reference_uniquename":"PMID:29761456"}],"product":"Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and translocation into the ER; other members are Sec63p, Sec62p, and Sec72p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000375","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR171W"}


id: YBR172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01279":null,"YBR172C":null},"has_protein_features":false,"name":"SMY2","ortholog_annotations":[{"gene_uniquename":"YBR172C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01279","reference_uniquename":"PMID:29761456"}],"product":"GYF domain protein; involved in COPII vesicle formation; regulates Cdc48p function in transcription stress response; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; homologous to human GIGYF1 and GIGYF2; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000376","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR172C"}


id: YBR173C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04290":null,"YBR173C":null},"has_protein_features":false,"name":"UMP1","ortholog_annotations":[{"gene_uniquename":"YBR173C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04290","reference_uniquename":"PMID:29761456"}],"product":"Chaperone required for correct maturation of the 20S proteasome; short-lived chaperone; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000377","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR173C"}


id: YBR174C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective","secondary_identifier":"SGD:S000000378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR174C"}


id: YBR175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02329":null,"YBR175W":null},"has_protein_features":false,"name":"SWD3","ortholog_annotations":[{"gene_uniquename":"YBR175W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02329","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR175W"}


id: YBR176W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05200":null,"YBR176W":null},"has_protein_features":false,"name":"ECM31","ortholog_annotations":[{"gene_uniquename":"YBR176W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05200","reference_uniquename":"PMID:29761456"}],"product":"Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR176W"}


id: YBR177C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EHT1","product":"Octanoyl-CoA:ethanol acyltransferase; also functions as thioesterase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR177C"}


id: YBR178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C","secondary_identifier":"SGD:S000000382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR178W"}


id: YBR179C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00031":null,"YBR179C":null},"has_protein_features":false,"name":"FZO1","ortholog_annotations":[{"gene_uniquename":"YBR179C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00031","reference_uniquename":"PMID:29761456"}],"product":"Mitofusin, protein involved in mitochondrial outer membrane fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system; activity regulated by ubiquitylation at conserved lysine residues and by  deubiquitylases Ubp2p and Ubp12p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000383","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR179C"}


id: YBR180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DTR1","product":"Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; sequence similarity to QDR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expressed during sporulation","secondary_identifier":"SGD:S000000384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR180W"}


id: YBR181C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03034":null,"SJAG_03859":null,"YBR181C":null},"has_protein_features":false,"name":"RPS6B","ortholog_annotations":[{"gene_uniquename":"YBR181C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR181C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03859","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR181C"}


id: YBR182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02218":null,"SJAG_04191":null,"YBR182C":null},"has_protein_features":false,"name":"SMP1","ortholog_annotations":[{"gene_uniquename":"YBR182C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02218","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YBR182C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04191","reference_uniquename":"PMID:29761456"}],"product":"MADS-box transcription factor involved in osmotic stress response; SMP1 has a paralog, RLM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR182C"}


id: YBR182C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028603","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR182C-A"}


id: YBR183W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YPC1","product":"Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR183W"}


id: YBR184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YBR184W is not an essential gene","secondary_identifier":"SGD:S000000388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR184W"}


id: YBR185C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01917":null,"YBR185C":null},"has_protein_features":false,"name":"MBA1","ortholog_annotations":[{"gene_uniquename":"YBR185C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01917","reference_uniquename":"PMID:29761456"}],"product":"Membrane-associated mitoribosome receptor; involved along with Dpi29p in the cotranslational insertion of nascent polypeptide chains into the inner mitochondrial membrane; associates with nascent polypeptide chains; interacts with Mdm38p and may recruit mRNA-specific translational activators to the mitoribosome; null mutant displays decreased tolerance to mistranslation-induced proteotoxic stress; localizes to the inner mitochondrial membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR185C"}


id: YBR186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PCH2","product":"Hexameric ring ATPase that remodels chromosome axis protein Hop1p; nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in rDNA; required for meiotic double-stranded break formation","secondary_identifier":"SGD:S000000390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR186W"}


id: YBR187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04096":null,"YBR187W":null},"has_protein_features":false,"name":"GDT1","ortholog_annotations":[{"gene_uniquename":"YBR187W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04096","reference_uniquename":"PMID:29761456"}],"product":"Calcium and manganese transporter with higher affinity for Ca2+; involved in Ca2+ and Mn2+ homeostasis; localizes to the cis- and medial-Golgi apparatus; GFP-fusion localizes to the vacuole; required for the Mn2+-dependent function of glycosylation enzymes; TMEM165, a human ortholog linked to Congenital Disorders of Glycosylation, functionally complements the null allele; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; expression regulated by Gcr1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR187W"}


id: YBR188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NTC20","product":"Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs","secondary_identifier":"SGD:S000000392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR188C"}


id: YBR189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00544":null,"SJAG_04342":null,"YBR189W":null},"has_protein_features":false,"name":"RPS9B","ortholog_annotations":[{"gene_uniquename":"YBR189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00544","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04342","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR189W"}


id: YBR190W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W","secondary_identifier":"SGD:S000000394","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR190W"}


id: YBR191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00155":null,"SJAG_01202":null,"YBR191W":null},"has_protein_features":false,"name":"RPL21A","ortholog_annotations":[{"gene_uniquename":"YBR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00155","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01202","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000395","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR191W"}


id: YBR191W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007594","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR191W-A"}


id: YBR192W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00154":null,"YBR192W":null},"has_protein_features":false,"name":"RIM2","ortholog_annotations":[{"gene_uniquename":"YBR192W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00154","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000396","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR192W"}


id: YBR193C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03622":null,"YBR193C":null},"has_protein_features":false,"name":"MED8","ortholog_annotations":[{"gene_uniquename":"YBR193C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03622","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000397","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR193C"}


id: YBR194W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00363":null,"YBR194W":null},"has_protein_features":false,"name":"AIM4","ortholog_annotations":[{"gene_uniquename":"YBR194W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00363","reference_uniquename":"PMID:29761456"}],"product":"Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000398","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR194W"}


id: YBR195C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01122":null,"SJAG_02439":null,"YBR195C":null},"has_protein_features":false,"name":"MSI1","ortholog_annotations":[{"gene_uniquename":"YBR195C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01122","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YBR195C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02439","reference_uniquename":"PMID:29761456"}],"product":"Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 affects multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription; Msi1p localizes to nucleus and cytoplasm and independently regulates the RAS/cAMP pathway via sequestration of Npr1p kinase","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000399","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR195C"}


id: YBR196C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00839":null,"YBR196C":null},"has_protein_features":false,"name":"PGI1","ortholog_annotations":[{"gene_uniquename":"YBR196C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00839","reference_uniquename":"PMID:29761456"}],"product":"Glycolytic enzyme phosphoglucose isomerase; catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000400","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR196C"}


id: YBR196C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR; ORF emerged de novo in thymine-rich ancestral non-genic region, accumulated substantial changes under positive selection, and progressively increased its transmembrane propensity to give rise to a protein that integrates into the endoplasmic reticulum (ER) membrane while retaining potential for adaptive change","secondary_identifier":"SGD:S000028534","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR196C-A"}


id: YBR196C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028816","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR196C-B"}


id: YBR197C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000401","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR197C"}


id: YBR198C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02541":null,"YBR198C":null},"has_protein_features":false,"name":"TAF5","ortholog_annotations":[{"gene_uniquename":"YBR198C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02541","reference_uniquename":"PMID:29761456"}],"product":"Subunit (90 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000402","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR198C"}


id: YBR199W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"YBR199W":null},"has_protein_features":false,"name":"KTR4","ortholog_annotations":[{"gene_uniquename":"YBR199W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR199W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR199W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"}],"product":"Glycosyltransferase involved in protein glycosylation; transfers GDP-mannose to methyl-alpha-mannoside in vitro; member of the KRE2/MNT1 mannosyltransferase family of type II membrane proteins with a short cytoplasmic N-terminus, a membrane-spanning region and a highly conserved catalytic lumenal domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000403","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR199W"}


id: YBR200W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01794":null,"YBR200W":null},"has_protein_features":false,"name":"BEM1","ortholog_annotations":[{"gene_uniquename":"YBR200W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01794","reference_uniquename":"PMID:29761456"}],"product":"Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000404","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR200W"}


id: YBR200W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028535","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR200W-A"}


id: YBR201C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIN7","product":"Mitochondrial protein of unknown function","secondary_identifier":"SGD:S000087085","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR201C-A"}


id: YBR201W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00681":null,"SJAG_03841":null,"YBR201W":null},"has_protein_features":false,"name":"DER1","ortholog_annotations":[{"gene_uniquename":"YBR201W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00681","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR201W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03841","reference_uniquename":"PMID:29761456"}],"product":"ER membrane protein that promotes export of misfolded polypeptides; required for ER-associated protein degradation of misfolded or unassembled proteins; initiates export of aberrant polypeptides from ER lumen by threading them into ER membrane and routing them to Hrd1p for ubiquitination; function normally requires N-terminal acetylation by NatB; N- and C- termini protrude into cytoplasm; similar to Dfm1p; homolog of mammalian derlin-1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000405","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR201W"}


id: YBR202W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00884":null,"YBR202W":null},"has_protein_features":false,"name":"MCM7","ortholog_annotations":[{"gene_uniquename":"YBR202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00884","reference_uniquename":"PMID:29761456"}],"product":"Component of the Mcm2-7 hexameric helicase complex; MCM2-7 primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000406","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR202W"}


id: YBR203W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS111","product":"Protein required for antifungal drug ciclopirox olamine resistance; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000000407","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR203W"}


id: YBR204C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03604":null,"YBR204C":null},"has_protein_features":false,"name":"LDH1","ortholog_annotations":[{"gene_uniquename":"YBR204C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03604","reference_uniquename":"PMID:29761456"}],"product":"Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000408","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR204C"}


id: YBR205W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"YBR205W":null},"has_protein_features":false,"name":"KTR3","ortholog_annotations":[{"gene_uniquename":"YBR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"}],"product":"Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000409","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR205W"}


id: YBR206W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3","secondary_identifier":"SGD:S000000410","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR206W"}


id: YBR207W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04675":null,"YBR207W":null},"has_protein_features":false,"name":"FTH1","ortholog_annotations":[{"gene_uniquename":"YBR207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04675","reference_uniquename":"PMID:29761456"}],"product":"Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000411","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR207W"}


id: YBR208C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DUR12","product":"Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000000412","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR208C"}


id: YBR209W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; YBR209W is not an essential gene","secondary_identifier":"SGD:S000000413","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR209W"}


id: YBR210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02264":null,"SJAG_04740":null,"YBR210W":null},"has_protein_features":false,"name":"ERV15","ortholog_annotations":[{"gene_uniquename":"YBR210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02264","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04740","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000414","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR210W"}


id: YBR211C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03619":null,"YBR211C":null},"has_protein_features":false,"name":"AME1","ortholog_annotations":[{"gene_uniquename":"YBR211C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03619","reference_uniquename":"PMID:29761456"}],"product":"Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000415","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR211C"}


id: YBR212W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00474":null,"SJAG_02573":null,"YBR212W":null},"has_protein_features":false,"name":"NGR1","ortholog_annotations":[{"gene_uniquename":"YBR212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00474","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YBR212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02573","reference_uniquename":"PMID:29761456"}],"product":"RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000416","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR212W"}


id: YBR213W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01786":null,"YBR213W":null},"has_protein_features":false,"name":"MET8","ortholog_annotations":[{"gene_uniquename":"YBR213W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01786","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional dehydrogenase and ferrochelatase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000417","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR213W"}


id: YBR214W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02380":null,"YBR214W":null},"has_protein_features":false,"name":"SDS24","ortholog_annotations":[{"gene_uniquename":"YBR214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02380","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000418","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR214W"}


id: YBR215W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04561":null,"YBR215W":null},"has_protein_features":false,"name":"HPC2","ortholog_annotations":[{"gene_uniquename":"YBR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04561","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000419","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR215W"}


id: YBR216C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02485":null,"YBR216C":null},"has_protein_features":false,"name":"YBP1","ortholog_annotations":[{"gene_uniquename":"YBR216C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02485","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000420","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR216C"}


id: YBR217W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06309":null,"YBR217W":null},"has_protein_features":false,"name":"ATG12","ortholog_annotations":[{"gene_uniquename":"YBR217W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06309","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-like modifier involved in autophagy and the Cvt pathway; conserved; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; homolog of mammalian ULK1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR217W"}


id: YBR218C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00464":null,"YBR218C":null},"has_protein_features":false,"name":"PYC2","ortholog_annotations":[{"gene_uniquename":"YBR218C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00464","reference_uniquename":"PMID:29761456"}],"product":"Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR218C"}


id: YBR219C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YBR219C is not an essential gene","secondary_identifier":"SGD:S000000423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR219C"}


id: YBR220C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04325":null,"YBR220C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBR220C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04325","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; YBR220C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000424","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR220C"}


id: YBR221C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03064":null,"YBR221C":null},"has_protein_features":false,"name":"PDB1","ortholog_annotations":[{"gene_uniquename":"YBR221C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03064","reference_uniquename":"PMID:29761456"}],"product":"E1 beta subunit of the pyruvate dehydrogenase (PDH) complex; PDH is an evolutionarily conserved multi-protein complex found in mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR221C"}


id: YBR221W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028817","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR221W-A"}


id: YBR222C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00947":null,"YBR222C":null},"has_protein_features":false,"name":"PCS60","ortholog_annotations":[{"gene_uniquename":"YBR222C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00947","reference_uniquename":"PMID:29761456"}],"product":"Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of oxalate; peroxisomal protein that binds mRNA; localizes to both peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid; similar to E. coli long chain acyl-CoA synthetase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000426","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR222C"}


id: YBR223C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04418":null,"YBR223C":null},"has_protein_features":false,"name":"TDP1","ortholog_annotations":[{"gene_uniquename":"YBR223C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04418","reference_uniquename":"PMID:29761456"}],"product":"Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topo I and topo II, including DNA-protein cross-links; mutations in the human homolog, TDP1, result in the neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy (SCAN1); yeast cells and human rhabdomyosarcoma lines that overexpress TDP1 both exhibit elevated dosage chromosomal instability (dCIN)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000427","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR223C"}


id: YBR223W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps YBR223C; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028604","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR223W-A"}


id: YBR224W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1","secondary_identifier":"SGD:S000000428","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR224W"}


id: YBR225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components","secondary_identifier":"SGD:S000000429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR225W"}


id: YBR226C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W","secondary_identifier":"SGD:S000000430","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR226C"}


id: YBR227C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MCX1","product":"Non-proteolytic ATPase of the AAA family; stimulates incorporation of the pyridoxal phosphate cofactor into Hem1p (5-aminolevulinic acid synthase); localized to the mitochondrial matrix; ortholog of vertebrate CLPX, which promotes erythropoiesis","secondary_identifier":"SGD:S000000431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR227C"}


id: YBR228W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05237":null,"YBR228W":null},"has_protein_features":false,"name":"SLX1","ortholog_annotations":[{"gene_uniquename":"YBR228W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05237","reference_uniquename":"PMID:29761456"}],"product":"Endonuclease involved in DNA recombination and repair; subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000432","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR228W"}


id: YBR229C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03280":null,"YBR229C":null},"has_protein_features":false,"name":"ROT2","ortholog_annotations":[{"gene_uniquename":"YBR229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03280","reference_uniquename":"PMID:29761456"}],"product":"Glucosidase II catalytic subunit; required to trim the final glucose in N-linked glycans; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000433","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR229C"}


id: YBR230C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OM14","product":"Mitochondrial outer membrane receptor for cytosolic ribosomes; integral protein of the outer membrane that interacts with the nascent chain-associated complex (NAC) bound to ribosomes, contributing to co-translational mitochondrial import; interacts with porin (Por1p) and Om45p; abundance is decreased in cells grown in glucose relative to other carbon sources","secondary_identifier":"SGD:S000000434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR230C"}


id: YBR230W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COQ21","product":"Mitochondrial protein of unknown function; YBR230W-A has a paralog, COQ8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000029722","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR230W-A"}


id: YBR231C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02466":null,"YBR231C":null},"has_protein_features":false,"name":"SWC5","ortholog_annotations":[{"gene_uniquename":"YBR231C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02466","reference_uniquename":"PMID:29761456"}],"product":"Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR231C"}


id: YBR232C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000436","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR232C"}


id: YBR233W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04825":null,"YBR233W":null},"has_protein_features":false,"name":"PBP2","ortholog_annotations":[{"gene_uniquename":"YBR233W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04825","reference_uniquename":"PMID:29761456"}],"product":"RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000437","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR233W"}


id: YBR233W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03437":null,"YBR233W-A":null},"has_protein_features":false,"name":"DAD3","ortholog_annotations":[{"gene_uniquename":"YBR233W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03437","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007595","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR233W-A"}


id: YBR234C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02075":null,"YBR234C":null},"has_protein_features":false,"name":"ARC40","ortholog_annotations":[{"gene_uniquename":"YBR234C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02075","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR234C"}


id: YBR235W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03401":null,"YBR235W":null},"has_protein_features":false,"name":"VHC1","ortholog_annotations":[{"gene_uniquename":"YBR235W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03401","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane cation-chloride cotransporter (CCC); involved in potassium homeostasis and salt tolerance; localizes to sites of contact between vacuole and mitochondria (vCLAMPs); targeted to vacuole via AP-3 pathway; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR235W"}


id: YBR236C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04034":null,"YBR236C":null},"has_protein_features":false,"name":"ABD1","ortholog_annotations":[{"gene_uniquename":"YBR236C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04034","reference_uniquename":"PMID:29761456"}],"product":"Methyltransferase; catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA; nuclear protein that relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000440","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR236C"}


id: YBR237W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02558":null,"YBR237W":null},"has_protein_features":false,"name":"PRP5","ortholog_annotations":[{"gene_uniquename":"YBR237W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02558","reference_uniquename":"PMID:29761456"}],"product":"RNA helicase in the DEAD-box family; necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR237W"}


id: YBR238C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01446":null,"YBR238C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBR238C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01446","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial membrane protein; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span; YBR238C has a paralog, RMD9, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000442","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR238C"}


id: YBR239C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ERT1","product":"Transcriptional regulator; involved in regulation of gluconeogenesis and fermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition; member of the zinc cluster family of proteins, similar to Rds2p","secondary_identifier":"SGD:S000000443","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR239C"}


id: YBR240C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"THI2","product":"Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type","secondary_identifier":"SGD:S000000444","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR240C"}


id: YBR241C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VVS1","product":"Putative transporter, member of the sugar porter family; localizes to the vacuolar membrane; non-essential gene; upregulated by and required for tolerance to 4-Methylcyclohexane methanol; YBR241C has a paralog, VPS73, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000445","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR241C"}


id: YBR242W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01055":null,"YBR242W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBR242W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01055","reference_uniquename":"PMID:29761456"}],"product":"5'-deoxynucleotidase involved in deoxyribonucleoside monophosphate degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential gene; YBR242W has a paralog, YGL101W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000446","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR242W"}


id: YBR243C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00924":null,"YBR243C":null},"has_protein_features":false,"name":"ALG7","ortholog_annotations":[{"gene_uniquename":"YBR243C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00924","reference_uniquename":"PMID:29761456"}],"product":"UDP-N-acetyl-glucosamine-1-P transferase; transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin; human homolog DPAGT1 can complement yeast ALG7 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000447","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR243C"}


id: YBR244W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01216":null,"YBR244W":null},"has_protein_features":false,"name":"GPX2","ortholog_annotations":[{"gene_uniquename":"YBR244W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01216","reference_uniquename":"PMID:29761456"}],"product":"Phospholipid hydroperoxide glutathione peroxidase; late-acting antioxidant system that decreases mitochondrial ROS production and preserves electron transport chain (ETC) function; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000448","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR244W"}


id: YBR245C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ISW1","product":"ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; with Ioc3p forms Isw1a complex involved in repression of transcription initiation; with Ioc2p and Ioc4p forms Isw1b complex involved in regulation of transcription elongation; Isw1b recruited to ORFs by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions; binds to 3'UTR of HAC1 mRNA and limits its nuclear export attenuating the UPR","secondary_identifier":"SGD:S000000449","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR245C"}


id: YBR246W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04846":null,"YBR246W":null},"has_protein_features":false,"name":"RRT2","ortholog_annotations":[{"gene_uniquename":"YBR246W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04846","reference_uniquename":"PMID:29761456"}],"product":"Methylesterase performing penultimate step of diphthamide biosynthesis; hydrolyzes methylated diphthine to produce diphthine and allows Dph6-catalyzed amidation reaction to occur; deletion leads to resistance to sordarin and accumulation of methylatediphthine; WD40 domain-containing protein; involved in endosomal recycling; forms complex with Rtt10p that functions in retromer-mediated pathway for recycling internalized cell-surface proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000450","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR246W"}


id: YBR247C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00897":null,"YBR247C":null},"has_protein_features":false,"name":"ENP1","ortholog_annotations":[{"gene_uniquename":"YBR247C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00897","reference_uniquename":"PMID:29761456"}],"product":"Protein associated with U3 and U14 snoRNAs; required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; human BYSL functionally complements the heat sensitivity of an enp1 ts mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000451","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR247C"}


id: YBR248C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03775":null,"YBR248C":null},"has_protein_features":false,"name":"HIS7","ortholog_annotations":[{"gene_uniquename":"YBR248C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03775","reference_uniquename":"PMID:29761456"}],"product":"Imidazole glycerol phosphate synthase; glutamine amidotransferase:cyclase that catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000452","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR248C"}


id: YBR249C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00224":null,"SJAG_03580":null,"YBR249C":null},"has_protein_features":false,"name":"ARO4","ortholog_annotations":[{"gene_uniquename":"YBR249C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00224","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR249C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03580","reference_uniquename":"PMID:29761456"}],"product":"3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000453","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR249C"}


id: YBR250W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPO23","product":"Protein of unknown function; associates with meiosis-specific protein Spo1p","secondary_identifier":"SGD:S000000454","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR250W"}


id: YBR251W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00628":null,"YBR251W":null},"has_protein_features":false,"name":"MRPS5","ortholog_annotations":[{"gene_uniquename":"YBR251W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00628","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR251W"}


id: YBR252W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04487":null,"YBR252W":null},"has_protein_features":false,"name":"DUT1","ortholog_annotations":[{"gene_uniquename":"YBR252W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04487","reference_uniquename":"PMID:29761456"}],"product":"Deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate; human homolog DUT allows growth of yeast haploid dut1 null mutant after sporulation of heterozygous diploid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000456","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR252W"}


id: YBR253W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05341":null,"YBR253W":null},"has_protein_features":false,"name":"SRB6","ortholog_annotations":[{"gene_uniquename":"YBR253W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05341","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000457","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR253W"}


id: YBR254C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03467":null,"YBR254C":null},"has_protein_features":false,"name":"TRS20","ortholog_annotations":[{"gene_uniquename":"YBR254C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03467","reference_uniquename":"PMID:29761456"}],"product":"Core component of transport protein particle (TRAPP) complexes I-III; TRAPPs are multimeric guanine nucleotide-exchange factors for GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); mutation leads to defects in endocytic recycling, block in sporulation/meiosis; mutations in human homolog TRAPPC2 cause spondyloepiphyseal dysplasia tarda, TRAPPC2 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000458","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR254C"}


id: YBR255C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RCF3","product":"Mitochondrial inner membrane protein; associates with respiratory chain supercomplexes III (ubiquinol-cytochrome c reductase) and IV (cytochrome c oxidase); identified by sequence comparison with hemiascomycetous yeast species","secondary_identifier":"SGD:S000007649","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR255C-A"}


id: YBR255W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MTC4","product":"Protein of unknown function; required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1","secondary_identifier":"SGD:S000000459","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR255W"}


id: YBR256C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02491":null,"YBR256C":null},"has_protein_features":false,"name":"RIB5","ortholog_annotations":[{"gene_uniquename":"YBR256C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02491","reference_uniquename":"PMID:29761456"}],"product":"Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000460","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR256C"}


id: YBR257W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01623":null,"YBR257W":null},"has_protein_features":false,"name":"POP4","ortholog_annotations":[{"gene_uniquename":"YBR257W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01623","reference_uniquename":"PMID:29761456"}],"product":"Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000461","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR257W"}


id: YBR258C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02170":null,"YBR258C":null},"has_protein_features":false,"name":"SHG1","ortholog_annotations":[{"gene_uniquename":"YBR258C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02170","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000462","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR258C"}


id: YBR259W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress","secondary_identifier":"SGD:S000000463","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR259W"}


id: YBR260C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01114":null,"YBR260C":null},"has_protein_features":false,"name":"RGD1","ortholog_annotations":[{"gene_uniquename":"YBR260C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01114","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein (RhoGAP) for Rho3p and Rho4p; involved in repolarization of actin cytoskeleton during adaptation to heat shock stress; phosphorylated by Pkc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000464","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR260C"}


id: YBR261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00508":null,"YBR261C":null},"has_protein_features":false,"name":"TAE1","ortholog_annotations":[{"gene_uniquename":"YBR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00508","reference_uniquename":"PMID:29761456"}],"product":"AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000465","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR261C"}


id: YBR262C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIC12","product":"Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic10p and Mic27p whose assembly and stability requires cardiolipin","secondary_identifier":"SGD:S000000466","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR262C"}


id: YBR263W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03914":null,"YBR263W":null},"has_protein_features":false,"name":"SHM1","ortholog_annotations":[{"gene_uniquename":"YBR263W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03914","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000467","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR263W"}


id: YBR264C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YPT10","product":"Rab family GTP-binding protein; contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles","secondary_identifier":"SGD:S000000468","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR264C"}


id: YBR265W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02488":null,"YBR265W":null},"has_protein_features":false,"name":"TSC10","ortholog_annotations":[{"gene_uniquename":"YBR265W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02488","reference_uniquename":"PMID:29761456"}],"product":"3-ketosphinganine reductase; catalyzes the second step in phytosphingosine synthesis; essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine; localized to lipid droplets; member of short chain dehydrogenase/reductase protein family; mutations in human homolog KDSR cause recessive progressive symmetric erythrokeratoderma","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000469","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR265W"}


id: YBR266C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SLM6","product":"Protein with potential role in actin cytoskeleton organization; null mutant is slow-growing, sensitive to Congo Red, impaired in endocytosis, has increased lifespan; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase","secondary_identifier":"SGD:S000000470","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR266C"}


id: YBR267W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03697":null,"YBR267W":null},"has_protein_features":false,"name":"REI1","ortholog_annotations":[{"gene_uniquename":"YBR267W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03697","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000471","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR267W"}


id: YBR268W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05244":null,"YBR268W":null},"has_protein_features":false,"name":"MRPL37","ortholog_annotations":[{"gene_uniquename":"YBR268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05244","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR268W"}


id: YBR269C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00703":null,"YBR269C":null},"has_protein_features":false,"name":"SDH8","ortholog_annotations":[{"gene_uniquename":"YBR269C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00703","reference_uniquename":"PMID:29761456"}],"product":"Protein required for assembly of succinate dehydrogenase; interacts with flavinylated Sdh1p and may function as a chaperone for free Sdh1p, protecting its FAD cofactor from redox reactions before assembly of the complex; soluble protein of the mitochondrial matrix; respiratory defect of null mutant is functionally complemented by Drosophila and human orthologs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000473","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR269C"}


id: YBR270C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01020":null,"SJAG_04987":null,"YBR270C":null},"has_protein_features":false,"name":"BIT2","ortholog_annotations":[{"gene_uniquename":"YBR270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01020","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04987","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000474","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR270C"}


id: YBR271W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01079":null,"YBR271W":null},"has_protein_features":false,"name":"EFM2","ortholog_annotations":[{"gene_uniquename":"YBR271W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01079","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which dimethylates translation elongation factor EF2 (Eft1p and Eft2p) at lysine 613 and methylates EF3 (Yef3p) at lysine 187; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; involved in regulation of translational termination; predicted involvement in ribosome biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000475","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR271W"}


id: YBR272C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HSM3","product":"Evolutionarily conserved 19S regulatory particle assembly-chaperone; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation; ortholog of human 19S subunit S5b","secondary_identifier":"SGD:S000000476","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR272C"}


id: YBR273C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UBX7","product":"UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000477","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR273C"}


id: YBR274W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01680":null,"YBR274W":null},"has_protein_features":false,"name":"CHK1","ortholog_annotations":[{"gene_uniquename":"YBR274W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01680","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine kinase and DNA damage checkpoint effector; mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000478","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR274W"}


id: YBR275C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01377":null,"YBR275C":null},"has_protein_features":false,"name":"RIF1","ortholog_annotations":[{"gene_uniquename":"YBR275C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01377","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in control of DNA replication; binds Rap1p C-terminus, telomeres, centromeres, replication origins; contributes to resection of DNA double strand breaks (DSBs); acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; in addition to controlling DNA replication initiation, plays ongoing role after initiation and controls events at blocked replication forks","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000479","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR275C"}


id: YBR276C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PPS1","product":"Protein phosphatase; has specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle","secondary_identifier":"SGD:S000000480","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR276C"}


id: YBR277C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W","secondary_identifier":"SGD:S000000481","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR277C"}


id: YBR278W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01823":null,"YBR278W":null},"has_protein_features":false,"name":"DPB3","ortholog_annotations":[{"gene_uniquename":"YBR278W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01823","reference_uniquename":"PMID:29761456"}],"product":"Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000482","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR278W"}


id: YBR279W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01610":null,"YBR279W":null},"has_protein_features":false,"name":"PAF1","ortholog_annotations":[{"gene_uniquename":"YBR279W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01610","reference_uniquename":"PMID:29761456"}],"product":"Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000483","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR279W"}


id: YBR280C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SAF1","product":"F-Box protein involved in proteasome-dependent degradation of Aah1p; involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1","secondary_identifier":"SGD:S000000484","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR280C"}


id: YBR281C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DUG2","product":"Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)","secondary_identifier":"SGD:S000000485","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR281C"}


id: YBR282W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04893":null,"YBR282W":null},"has_protein_features":false,"name":"MRPL27","ortholog_annotations":[{"gene_uniquename":"YBR282W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04893","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000486","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR282W"}


id: YBR283C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02208":null,"YBR283C":null},"has_protein_features":false,"name":"SSH1","ortholog_annotations":[{"gene_uniquename":"YBR283C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02208","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000487","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR283C"}


id: YBR284W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000488","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR284W"}


id: YBR285W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HAB1","product":"Autophagy receptor; highly enriched in autophagic body fractions of both rapamycin-treated and nitrogen-starved cells; binds directly to forming isolation membranes during bulk autophagy; small protein of 144 amino acid residues without any identifiable membrane-spanning regions; N-terminal 42 amino acid region contains an amphipathic helix and an Atg8-family interacting motif","secondary_identifier":"SGD:S000000489","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR285W"}


id: YBR286W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"APE3","product":"Vacuolar aminopeptidase Y; processed to mature form by Prb1p; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway","secondary_identifier":"SGD:S000000490","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR286W"}


id: YBR287W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01514":null,"YBR287W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBR287W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01514","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000491","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR287W"}


id: YBR288C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04931":null,"YBR288C":null},"has_protein_features":false,"name":"APM3","ortholog_annotations":[{"gene_uniquename":"YBR288C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04931","reference_uniquename":"PMID:29761456"}],"product":"Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000492","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR288C"}


id: YBR289W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01111":null,"YBR289W":null},"has_protein_features":false,"name":"SNF5","ortholog_annotations":[{"gene_uniquename":"YBR289W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01111","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000493","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR289W"}


id: YBR290W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01527":null,"YBR290W":null},"has_protein_features":false,"name":"BSD2","ortholog_annotations":[{"gene_uniquename":"YBR290W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01527","reference_uniquename":"PMID:29761456"}],"product":"Heavy metal ion homeostasis protein; facilitates trafficking of Smf1p and Smf2p metal transporters to vacuole where they are degraded; acts as an adaptor protein with Rsp5p in the regulated endocytosis of Smf1p and is itself ubiquitylated by Rsp5p; controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000494","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR290W"}


id: YBR291C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01872":null,"YBR291C":null},"has_protein_features":false,"name":"CTP1","ortholog_annotations":[{"gene_uniquename":"YBR291C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01872","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000495","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR291C"}


id: YBR292C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; YBR292C is not an essential gene","secondary_identifier":"SGD:S000000496","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR292C"}


id: YBR293W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02029":null,"SJAG_04725":null,"YBR293W":null},"has_protein_features":false,"name":"VBA2","ortholog_annotations":[{"gene_uniquename":"YBR293W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02029","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR293W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04725","reference_uniquename":"PMID:29761456"}],"product":"Permease of basic amino acids in the vacuolar membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000497","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR293W"}


id: YBR294W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02463":null,"YBR294W":null},"has_protein_features":false,"name":"SUL1","ortholog_annotations":[{"gene_uniquename":"YBR294W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02463","reference_uniquename":"PMID:29761456"}],"product":"High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000498","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR294W"}


id: YBR295W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PCA1","product":"Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function","secondary_identifier":"SGD:S000000499","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR295W"}


id: YBR296C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PHO89","product":"Plasma membrane Na+/Pi cotransporter; active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification","secondary_identifier":"SGD:S000000500","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR296C"}


id: YBR296C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TYC1","product":"Inhibitor of the Anaphase-Promoting Complex/Cyclosome (APC/C); binds to APC/C and inhibits the activity of both APC/C(Cdc20) and APC/C(Cdh1); inhibits the binding of Cdc20 and Cdh1 to APC/C; overexpression results in increased sensitivity to microtubule poison; localizes to peroxisomes; originally identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; functional homolog of human MAD2L1BP (p31comet)","secondary_identifier":"SGD:S000028605","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR296C-A"}


id: YBR297W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MAL33","product":"MAL-activator protein; part of complex locus MAL3; nonfunctional in genomic reference strain S288C","secondary_identifier":"SGD:S000000501","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR297W"}


id: YBR298C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MAL31","product":"Maltose permease; high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C","secondary_identifier":"SGD:S000000502","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR298C"}


id: YBR298C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028606","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR298C-A"}


id: YBR299W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MAL32","product":"Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose","secondary_identifier":"SGD:S000000503","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR299W"}


id: YBR300C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene","secondary_identifier":"SGD:S000000504","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR300C"}


id: YBR301W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU24","product":"Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth","secondary_identifier":"SGD:S000000505","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR301W"}


id: YBR302C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS2","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000000506","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR302C"}


id: YCL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04402":null,"YCL001W":null},"has_protein_features":false,"name":"RER1","ortholog_annotations":[{"gene_uniquename":"YCL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04402","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in retention of membrane proteins; including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000507","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL001W"}


id: YCL001W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III","secondary_identifier":"SGD:S000007221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL001W-A"}


id: YCL001W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication","secondary_identifier":"SGD:S000007596","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL001W-B"}


id: YCL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YCL002C is not an essential gene","secondary_identifier":"SGD:S000000508","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL002C"}


id: YCL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCL003W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YCL004w","secondary_identifier":"SGD:S000000509","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL003W"}


id: YCL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00168":null,"YCL004W":null},"has_protein_features":false,"name":"PGS1","ortholog_annotations":[{"gene_uniquename":"YCL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00168","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylglycerolphosphate synthase; catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000510","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL004W"}


id: YCL005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LDB16","product":"Protein involved in lipid droplet (LD) assembly; forms a complex with Sei1p at ER-LD contact sites, stabilizing contact sites; ensures that LDs bud from the ER towards the cytosolic side of the membrane; null mutants have decreased net negative cell surface charge and localized accumulation of phosphatidic acid (PA) marker proteins; GFP-fusion protein expression is induced in response to MMS; null mutant can be complemented by the human seipin, BSCL2","secondary_identifier":"SGD:S000000511","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL005W"}


id: YCL005W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05294":null,"YCL005W-A":null},"has_protein_features":false,"name":"VMA9","ortholog_annotations":[{"gene_uniquename":"YCL005W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05294","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028508","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL005W-A"}


id: YCL006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this ORF was removed when a sequence update created a stop codon after residue 23","secondary_identifier":"SGD:S000000512","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL006C"}


id: YCL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A","secondary_identifier":"SGD:S000000513","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL007C"}


id: YCL008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01981":null,"YCL008C":null},"has_protein_features":false,"name":"STP22","ortholog_annotations":[{"gene_uniquename":"YCL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01981","reference_uniquename":"PMID:29761456"}],"product":"Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; prevents polyubiquitination of the arrestin-related protein Rim8p, thereby directing its monoubiquitination by Rsp5p; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype;","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000514","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL008C"}


id: YCL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06635":null,"YCL009C":null},"has_protein_features":false,"name":"ILV6","ortholog_annotations":[{"gene_uniquename":"YCL009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06635","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of acetolactate synthase; acetolactate synthase catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000515","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL009C"}


id: YCL010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00184":null,"YCL010C":null},"has_protein_features":false,"name":"SGF29","ortholog_annotations":[{"gene_uniquename":"YCL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00184","reference_uniquename":"PMID:29761456"}],"product":"Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000516","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL010C"}


id: YCL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01529":null,"YCL011C":null},"has_protein_features":false,"name":"GBP2","ortholog_annotations":[{"gene_uniquename":"YCL011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01529","reference_uniquename":"PMID:29761456"}],"product":"Poly(A+) RNA-binding protein involved in translation repression; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; relocalizes to the cytosol in response to hypoxia; GBP2 has a paralog, HRB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000517","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL011C"}


id: YCL012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00725":null,"YCL012C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YCL012C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00725","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000029705","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL012C"}


id: YCL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCL012W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YCL014W","secondary_identifier":"SGD:S000000518","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL012W"}


id: YCL013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; originally included in genome annotation but deleted due to sequence correction","secondary_identifier":"SGD:S000000519","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL013W"}


id: YCL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUD3","product":"Guanine nucleotide exchange factor (GEF) for Cdc42p; activates Cdc42p in early G1, accounting for the first stage of biphasic activation, with Cdc24p accounting for the second stage in late G1; involved in the Cdc42p-mediated assembly of the axial landmark that dictates the site for the next round of budding, resulting in the axial budding pattern in haploids; localizes with septins to the bud neck contractile ring in mitosis","secondary_identifier":"SGD:S000000520","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL014W"}


id: YCL016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00806":null,"YCL016C":null},"has_protein_features":false,"name":"DCC1","ortholog_annotations":[{"gene_uniquename":"YCL016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00806","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a complex with Ctf8p and Ctf18p; shares some components with Replication Factor C; required for sister chromatid cohesion and telomere length maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL016C"}


id: YCL017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00186":null,"YCL017C":null},"has_protein_features":false,"name":"NFS1","ortholog_annotations":[{"gene_uniquename":"YCL017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00186","reference_uniquename":"PMID:29761456"}],"product":"Cysteine desulfurase involved in iron-sulfur cluster biogenesis; required for thio-modification of mitochondrial and cytoplasmic tRNAs; involved in DNA damage response by providing iron-sulfur cluster cofactors for DNA repair enzymes; essential protein located predominantly in mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL017C"}


id: YCL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03562":null,"YCL018W":null},"has_protein_features":false,"name":"LEU2","ortholog_annotations":[{"gene_uniquename":"YCL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03562","reference_uniquename":"PMID:29761456"}],"product":"Beta-isopropylmalate dehydrogenase (IMDH); catalyzes the third step in the leucine biosynthesis pathway; can additionally catalyze the conversion of beta-ethylmalate into alpha-ketovalerate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL018W"}


id: YCL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; originally included in genome annotation, but later deleted due to sequence correction","secondary_identifier":"SGD:S000000526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL021W"}


id: YCL021W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the vacuole","secondary_identifier":"SGD:S000007549","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL021W-A"}


id: YCL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W","secondary_identifier":"SGD:S000000527","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL022C"}


id: YCL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4","secondary_identifier":"SGD:S000000528","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL023C"}


id: YCL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03602":null,"SJAG_04486":null,"YCL024W":null},"has_protein_features":false,"name":"KCC4","ortholog_annotations":[{"gene_uniquename":"YCL024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03602","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04486","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000529","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL024W"}


id: YCL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YCL025C":null},"has_protein_features":false,"name":"AGP1","ortholog_annotations":[{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"Broad-specificity, low-affinity amino acid permease; minor serine permease with major contributions from paralog Gnp1p; involved in uptake of asparagine, glutamine, and other amino acids; expression induced by amino acids and regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000530","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL025C"}


id: YCL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; included in the original annotation of Chromosome III but later deleted due to sequence corrections","secondary_identifier":"SGD:S000000531","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL026C"}


id: YCL026C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FRM2","product":"Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin","secondary_identifier":"SGD:S000000589","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL026C-A"}


id: YCL026C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HBN1","product":"Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000007548","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL026C-B"}


id: YCL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FUS1","product":"Membrane protein localized to the shmoo tip; required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate","secondary_identifier":"SGD:S000000532","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL027W"}


id: YCL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RNQ1","product":"[PIN(+)] prion, named for [PSI+] INducibility; an infectious protein conformation that is generally an ordered protein aggregate","secondary_identifier":"SGD:S000000533","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL028W"}


id: YCL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02695":null,"YCL029C":null},"has_protein_features":false,"name":"BIK1","ortholog_annotations":[{"gene_uniquename":"YCL029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02695","reference_uniquename":"PMID:29761456"}],"product":"Microtubule-associated protein; component of the interface between microtubules and the kinetochore; involved in sister chromatid separation and mitotic spindle elongation; involved in karyogamy during mating; stabilizes Kip2p at microtubule plus ends and recruits Kip2p to mitotic SPBs; essential in polyploid cells but not in haploid or diploid cells; promotes plus-end directed movement of Dyn1p; ortholog of mammalian CLIP-170","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000534","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL029C"}


id: YCL030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01137":null,"SJAG_02400":null,"YCL030C":null},"has_protein_features":false,"name":"HIS4","ortholog_annotations":[{"gene_uniquename":"YCL030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01137","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02400","reference_uniquename":"PMID:29761456"}],"product":"Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000535","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL030C"}


id: YCL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03617":null,"YCL031C":null},"has_protein_features":false,"name":"RRP7","ortholog_annotations":[{"gene_uniquename":"YCL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03617","reference_uniquename":"PMID:29761456"}],"product":"Essential protein involved in rRNA processing and ribosome biogenesis; forms a complex with Utp22p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000536","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL031C"}


id: YCL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03340":null,"YCL032W":null},"has_protein_features":false,"name":"STE50","ortholog_annotations":[{"gene_uniquename":"YCL032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03340","reference_uniquename":"PMID:29761456"}],"product":"Adaptor protein for various signaling pathways; involved in the mating response, invasive/filamentous growth and osmotolerance; acts as an adaptor that links the G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction; localizes to cortical patches at the site of shmoo initiation, facilitating polarity establishment, and remaining at the shmoo tip during mating","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000537","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL032W"}


id: YCL033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00365":null,"YCL033C":null},"has_protein_features":false,"name":"MXR2","ortholog_annotations":[{"gene_uniquename":"YCL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00365","reference_uniquename":"PMID:29761456"}],"product":"Methionine-R-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000538","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL033C"}


id: YCL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00907":null,"YCL034W":null},"has_protein_features":false,"name":"LSB5","ortholog_annotations":[{"gene_uniquename":"YCL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00907","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in membrane-trafficking events at plasma membrane; interacts with actin regulators Sla1p and Las17p, ubiquitin, Arf3p to couple actin dynamics to membrane trafficking processes; similar structure to GGA family of proteins with N-terminal VHS domain and GAT domain; binds Las17p, which is homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly, actin polymerization; may mediate disassembly of Pan1 complex from endocytic coat","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000539","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL034W"}


id: YCL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01292":null,"SJAG_04632":null,"YCL035C":null},"has_protein_features":false,"name":"GRX1","ortholog_annotations":[{"gene_uniquename":"YCL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01292","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04632","reference_uniquename":"PMID:29761456"}],"product":"Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000540","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL035C"}


id: YCL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03874":null,"YCL036W":null},"has_protein_features":false,"name":"GFD2","ortholog_annotations":[{"gene_uniquename":"YCL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03874","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000541","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL036W"}


id: YCL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01026":null,"YCL037C":null},"has_protein_features":false,"name":"SRO9","ortholog_annotations":[{"gene_uniquename":"YCL037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01026","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic RNA-binding protein; shuttles between nucleus and cytoplasm and is exported from the nucleus in an mRNA export-dependent manner; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; role in preventing L-A mycovirus pathogenesis; SRO9 has a paralog, SLF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000542","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL037C"}


id: YCL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03899":null,"YCL038C":null},"has_protein_features":false,"name":"ATG22","ortholog_annotations":[{"gene_uniquename":"YCL038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03899","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane protein; required for efflux of amino acids during autophagic body breakdown in vacuole; targeted to vacuole via AP-3 pathway; null mutation causes gradual loss of viability during starvation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000543","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL038C"}


id: YCL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01472":null,"YCL039W":null},"has_protein_features":false,"name":"GID7","ortholog_annotations":[{"gene_uniquename":"YCL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01472","reference_uniquename":"PMID:29761456"}],"product":"Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; localizes to peroxisomes in oleate-growing cells; computational analysis suggests that Gid7p and Moh1p have similar functions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000544","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL039W"}


id: YCL040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04495":null,"YCL040W":null},"has_protein_features":false,"name":"GLK1","ortholog_annotations":[{"gene_uniquename":"YCL040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04495","reference_uniquename":"PMID:29761456"}],"product":"Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000545","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL040W"}


