# genes

id: YLL055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04295":null,"YLL055W":null},"has_protein_features":false,"name":"YCT1","ortholog_annotations":[{"gene_uniquename":"YLL055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04295","reference_uniquename":"PMID:29761456"}],"product":"High-affinity cysteine-specific transporter; has similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003978","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL055W"}


id: YLL056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"NADH-dependent aldehyde reductase; reduces many aldehyde compounds including glycolaldehyde, formaldehyde and furfural; transcription unregulated by furfural, 5-hydroxymethylfurfural (HMF) and the mycotoxin patulin; expression increased by multidrug resistance transcription factors Yrm1p and Yrr1p; member of atypical subgroup 7 of the short-chain dehydrogenase/reductase (SDR) family; localizes to the cytoplasm; SWAT-GFP and mCherry fusion proteins localize to the ER and vacuole respectively","secondary_identifier":"SGD:S000003979","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL056C"}


id: YLL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"JLP1","product":"Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation","secondary_identifier":"SGD:S000003980","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL057C"}


id: YLL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03102":null,"YLL058W":null},"has_protein_features":false,"name":"HSU1","ortholog_annotations":[{"gene_uniquename":"YLL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03102","reference_uniquename":"PMID:29761456"}],"product":"Inefficient homocysteine synthase; catalyzes de novo homocysteine biosynthesis; capable of catalyzing same reaction as Met17p; affects S-methylmethionine metabolism; similar to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; HSU1 is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003981","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL058W"}


id: YLL059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003982","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL059C"}


id: YLL060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GTT2","product":"Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003983","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL060C"}


id: YLL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MMP1","product":"High-affinity S-methylmethionine permease; required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p","secondary_identifier":"SGD:S000003984","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL061W"}


id: YLL062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04425":null,"YLL062C":null},"has_protein_features":false,"name":"MHT1","ortholog_annotations":[{"gene_uniquename":"YLL062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04425","reference_uniquename":"PMID:29761456"}],"product":"S-methylmethionine-homocysteine methyltransferase; functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003985","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL062C"}


id: YLL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00020":null,"SJAG_00021":null,"SJAG_00075":null,"SJAG_01363":null,"SJAG_02126":null,"SJAG_02127":null,"SJAG_02940":null,"YLL063C":null},"has_protein_features":false,"name":"AYT1","ortholog_annotations":[{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00020","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00021","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00075","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01363","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02126","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02127","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02940","reference_uniquename":"PMID:26896847"}],"product":"Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis; localized to peroxisomes","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000003986","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL063C"}


id: YLL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU18","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau6p","secondary_identifier":"SGD:S000003987","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL064C"}


id: YLL065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps chromosome XII telomeric element core sequences","secondary_identifier":"SGD:S000003988","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL065W"}


id: YLL066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative Y' element ATP-dependent helicase; YLL066C is not an essential gene","secondary_identifier":"SGD:S000003989","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL066C"}


id: YLL066W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YLL066C","secondary_identifier":"SGD:S000028671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL066W-A"}


id: YLL066W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; overexpression causes a cell cycle delay or arrest","secondary_identifier":"SGD:S000028672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL066W-B"}


id: YLL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative Y' element ATP-dependent helicase","secondary_identifier":"SGD:S000003990","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL067C"}


id: YLL067W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps YLL067C","secondary_identifier":"SGD:S000028673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL067W-A"}


id: YLR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00732":null,"YLR001C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00732","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003991","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR001C"}


id: YLR002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00311":null,"YLR002C":null},"has_protein_features":false,"name":"NOC3","ortholog_annotations":[{"gene_uniquename":"YLR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00311","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003992","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR002C"}


id: YLR003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01115":null,"YLR003C":null},"has_protein_features":false,"name":"CMS1","ortholog_annotations":[{"gene_uniquename":"YLR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01115","reference_uniquename":"PMID:29761456"}],"product":"Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003993","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR003C"}


id: YLR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02139":null,"SJAG_05182":null,"YLR004C":null},"has_protein_features":false,"name":"THI73","ortholog_annotations":[{"gene_uniquename":"YLR004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02139","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05182","reference_uniquename":"PMID:29761456"}],"product":"Putative plasma membrane permease; proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003994","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR004C"}


id: YLR005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00758":null,"YLR005W":null},"has_protein_features":false,"name":"SSL1","ortholog_annotations":[{"gene_uniquename":"YLR005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00758","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the core form of RNA polymerase transcription factor TFIIH; has both protein kinase and DNA-dependent ATPase/helicase activities; essential for transcription and nucleotide excision repair; interacts with Tfb4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003995","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR005W"}


id: YLR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00318":null,"YLR006C":null},"has_protein_features":false,"name":"SSK1","ortholog_annotations":[{"gene_uniquename":"YLR006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00318","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic phosphorelay intermediate osmosensor and regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003996","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR006C"}


id: YLR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05323":null,"YLR007W":null},"has_protein_features":false,"name":"NSE1","ortholog_annotations":[{"gene_uniquename":"YLR007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05323","reference_uniquename":"PMID:29761456"}],"product":"Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003997","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR007W"}


id: YLR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01597":null,"YLR008C":null},"has_protein_features":false,"name":"PAM18","ortholog_annotations":[{"gene_uniquename":"YLR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01597","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the import motor (PAM complex); the PAM complex is a  component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003998","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR008C"}


id: YLR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04395":null,"YLR009W":null},"has_protein_features":false,"name":"RLP24","ortholog_annotations":[{"gene_uniquename":"YLR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04395","reference_uniquename":"PMID:29761456"}],"product":"Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003999","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR009W"}


id: YLR010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04245":null,"YLR010C":null},"has_protein_features":false,"name":"TEN1","ortholog_annotations":[{"gene_uniquename":"YLR010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04245","reference_uniquename":"PMID:29761456"}],"product":"Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p; similar to human Ten1 which is critical for the telomeric function of the CST (Cdc13p-Stn1p-Ten1p) complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004000","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR010C"}


id: YLR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LOT6","product":"FMN-dependent NAD(P)H:quinone reductase; role in apoptosis-like cell death; may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions","secondary_identifier":"SGD:S000004001","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR011W"}


id: YLR012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YLR012C is not an essential gene","secondary_identifier":"SGD:S000004002","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR012C"}


id: YLR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GAT3","product":"Protein containing GATA family zinc finger motifs; involved in spore wall assembly; sequence similarity to GAT4, and the double mutant gat3 gat4 exhibits reduced dityrosine fluorescence relative to the single mutants","secondary_identifier":"SGD:S000004003","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR013W"}


id: YLR014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PPR1","product":"Zinc finger transcription factor; contains a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p","secondary_identifier":"SGD:S000004004","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR014C"}


id: YLR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00896":null,"YLR015W":null},"has_protein_features":false,"name":"BRE2","ortholog_annotations":[{"gene_uniquename":"YLR015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00896","reference_uniquename":"PMID:29761456"}],"product":"Subunit of COMPASS (Set1C) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004005","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR015W"}


id: YLR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PML1","product":"Subunit of the RES complex; RES complex is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p","secondary_identifier":"SGD:S000004006","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR016C"}


id: YLR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03881":null,"YLR017W":null},"has_protein_features":false,"name":"MEU1","ortholog_annotations":[{"gene_uniquename":"YLR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03881","reference_uniquename":"PMID:29761456"}],"product":"Methylthioadenosine phosphorylase (MTAP); catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004007","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR017W"}


id: YLR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03281":null,"YLR018C":null},"has_protein_features":false,"name":"POM34","ortholog_annotations":[{"gene_uniquename":"YLR018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03281","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004008","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR018C"}


id: YLR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02389":null,"SJAG_04128":null,"YLR019W":null},"has_protein_features":false,"name":"PSR2","ortholog_annotations":[{"gene_uniquename":"YLR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02389","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04128","reference_uniquename":"PMID:29761456"}],"product":"Putative plasma membrane phosphatase; involved in the general stress response and inactivating dephosphorylation of Mep2p; required along with Psr1p and binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through Msn2p dephosphorylation, and for inhibition of TORC1 in response to limiting amino acids; regulates the sodium ion stress response with Psr1p; member of the HAD family of protein phosphatases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004009","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR019W"}


id: YLR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YEH2","product":"Steryl ester hydrolase; catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; YEH2 has a paralog, YEH1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004010","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR020C"}


id: YLR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04602":null,"YLR021W":null},"has_protein_features":false,"name":"IRC25","ortholog_annotations":[{"gene_uniquename":"YLR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04602","reference_uniquename":"PMID:29761456"}],"product":"Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004011","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR021W"}


id: YLR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04491":null,"YLR022C":null},"has_protein_features":false,"name":"SDO1","ortholog_annotations":[{"gene_uniquename":"YLR022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04491","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF) for Ria1p; essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004012","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR022C"}


id: YLR023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02080":null,"YLR023C":null},"has_protein_features":false,"name":"IZH3","ortholog_annotations":[{"gene_uniquename":"YLR023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02080","reference_uniquename":"PMID:29761456"}],"product":"Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004013","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR023C"}


id: YLR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01253":null,"SJAG_04619":null,"YLR024C":null},"has_protein_features":false,"name":"UBR2","ortholog_annotations":[{"gene_uniquename":"YLR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01253","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04619","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic ubiquitin-protein ligase (E3); component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex required for the ubiquitination and degradation of Rpn4p; mediates formation of the ternary complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004014","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR024C"}


id: YLR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01242":null,"YLR025W":null},"has_protein_features":false,"name":"SNF7","ortholog_annotations":[{"gene_uniquename":"YLR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01242","reference_uniquename":"PMID:29761456"}],"product":"One of four core subunits of the ESCRT-III complex; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes; subunit of the endosomal sorting complex required for transport III (ESCRT-III) that forms flat spirals on lipid monolayers as part of the complexes role in driving membrane abscission","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004015","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR025W"}


id: YLR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03552":null,"YLR026C":null},"has_protein_features":false,"name":"SED5","ortholog_annotations":[{"gene_uniquename":"YLR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03552","reference_uniquename":"PMID:29761456"}],"product":"cis-Golgi t-SNARE syntaxin; required for vesicular transport between the ER and the Golgi complex; binds at least 9 SNARE proteins; plays a role in autophagy by regulating formation of autophagic vesicles in Golgi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004016","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR026C"}


id: YLR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03306":null,"YLR027C":null},"has_protein_features":false,"name":"AAT2","ortholog_annotations":[{"gene_uniquename":"YLR027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03306","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic aspartate aminotransferase involved in the metabolism of nitrogen and amino acids such as aspartate; localizes to and functions in peroxisomes in oleate-grown cells; moonlighting role as a ribosome-associated protein that modulates translation in response to stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004017","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR027C"}


id: YLR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04681":null,"YLR028C":null},"has_protein_features":false,"name":"ADE16","ortholog_annotations":[{"gene_uniquename":"YLR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04681","reference_uniquename":"PMID:29761456"}],"product":"Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004018","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR028C"}


id: YLR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03919":null,"SJAG_04478":null,"YLR029C":null},"has_protein_features":false,"name":"RPL15A","ortholog_annotations":[{"gene_uniquename":"YLR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03919","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04478","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004019","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR029C"}


id: YLR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W","secondary_identifier":"SGD:S000004020","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR030W"}


id: YLR031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W; YLR031W has a paralog, YMR124W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004021","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR031W"}


id: YLR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02521":null,"YLR032W":null},"has_protein_features":false,"name":"RAD5","ortholog_annotations":[{"gene_uniquename":"YLR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02521","reference_uniquename":"PMID:29761456"}],"product":"DNA helicase/Ubiquitin ligase; involved in error-free DNA damage tolerance (DDT), replication fork regression during postreplication repair by template switching, and error-prone translesion synthesis; required for UV and MMS-associated unequal sister chromatid exchange (SCE) but not for double-strand break associated unequal SCE; promotes synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; human homolog HLTF can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004022","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR032W"}


id: YLR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03758":null,"YLR033W":null},"has_protein_features":false,"name":"RSC58","ortholog_annotations":[{"gene_uniquename":"YLR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03758","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004023","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR033W"}


id: YLR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01007":null,"YLR034C":null},"has_protein_features":false,"name":"SMF3","ortholog_annotations":[{"gene_uniquename":"YLR034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01007","reference_uniquename":"PMID:29761456"}],"product":"Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of Nramp family of metal transport proteins; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004024","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR034C"}


id: YLR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MLH2","product":"Protein involved in mismatch repair and meiotic recombination; only certain frameshift intermediates are mismatch repair substrates; forms a complex with Mlh1p, plays accessory role in stimulating activity of MLH1/PMS1 complex","secondary_identifier":"SGD:S000004025","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR035C"}


id: YLR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein","secondary_identifier":"SGD:S000004026","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR036C"}


id: YLR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU23","product":"Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth","secondary_identifier":"SGD:S000004027","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR037C"}


id: YLR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02504":null,"YLR038C":null},"has_protein_features":false,"name":"COX12","ortholog_annotations":[{"gene_uniquename":"YLR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02504","reference_uniquename":"PMID:29761456"}],"product":"Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly and activity of cytochrome c oxidase; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004028","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR038C"}


id: YLR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00143":null,"YLR039C":null},"has_protein_features":false,"name":"RIC1","ortholog_annotations":[{"gene_uniquename":"YLR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00143","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004029","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR039C"}


id: YLR040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AFB1","product":"MATalpha-specific a-factor blocker; contributes to mating efficiency under certain conditions; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W","secondary_identifier":"SGD:S000004030","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR040C"}


id: YLR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C","secondary_identifier":"SGD:S000004031","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR041W"}


id: YLR042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NFG1","product":"Negative regulator of the filamentous growth pathway; inhibits invasive growth by dampening the activity of the filamentous MAPK pathway; localizes to the cell wall and to the vacuole and cell periphery in HTP studies; deletion improves xylose fermentation in industrially engineered strains; nonessential gene","secondary_identifier":"SGD:S000004032","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR042C"}


id: YLR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04953":null,"YLR043C":null},"has_protein_features":false,"name":"TRX1","ortholog_annotations":[{"gene_uniquename":"YLR043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04953","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system that protects cells from oxidative and reductive stress; subunit of the LMA1 complex, with Pbi2p, that promotes vacuole inheritance; cofactor for Tsa1p; required for ER-Golgi transport; facilitates mitochondrial import of small Tims (Tim9p, Tim10p, Tim13p) by maintaining them in reduced form along with Trx2p; component of a signal transduction redox relay in a light sensing pathway; abundance increases under DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004033","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR043C"}


id: YLR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02734":null,"SJAG_03743":null,"SJAG_04842":null,"YLR044C":null},"has_protein_features":false,"name":"PDC1","ortholog_annotations":[{"gene_uniquename":"YLR044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02734","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03743","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04842","reference_uniquename":"PMID:29761456"}],"product":"Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo; protein tyrosine nitration on Tyr157 or Tyr344 inhibits activity and impairs fermentation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004034","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR044C"}


id: YLR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02624":null,"SJAG_03540":null,"YLR045C":null},"has_protein_features":false,"name":"STU2","ortholog_annotations":[{"gene_uniquename":"YLR045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02624","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03540","reference_uniquename":"PMID:29761456"}],"product":"Microtubule polymerase of the XMAP215/Dis1 family; required for elongation of mitotic spindle during anaphase, as well as for spindle orientation and metaphase chromosome alignment; stabilizes or destabilizes kinetochore-microtubule attachment depending on kinetochore tension; interacts with spindle pole body component Spc72p; metazoan ch-TOG/XMAP215 family member","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004035","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR045C"}


id: YLR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00018":null,"SJAG_00587":null,"SJAG_00589":null,"SJAG_01095":null,"SJAG_02114":null,"SJAG_02132":null,"SJAG_02581":null,"SJAG_02943":null,"SJAG_02957":null,"YLR046C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00018","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00587","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00589","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01095","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02114","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02132","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02581","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02943","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02957","reference_uniquename":"PMID:29761456"}],"product":"Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YLR046C has a paralog, RTA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004036","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR046C"}


id: YLR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04743":null,"YLR047C":null},"has_protein_features":false,"name":"FRE8","ortholog_annotations":[{"gene_uniquename":"YLR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Protein with sequence similarity to iron/copper reductases; involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004037","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR047C"}


id: YLR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02184":null,"SJAG_02479":null,"SJAG_02803":null,"YLR048W":null},"has_protein_features":false,"name":"RPS0B","ortholog_annotations":[{"gene_uniquename":"YLR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02184","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02479","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02803","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004038","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR048W"}


id: YLR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MLO50","product":"Mitochondrial protein of unknown function","secondary_identifier":"SGD:S000004039","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR049C"}


id: YLR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07010":null,"YLR050C":null},"has_protein_features":false,"name":"EMA19","ortholog_annotations":[{"gene_uniquename":"YLR050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07010","reference_uniquename":"PMID:29761456"}],"product":"Integral ER membrane protein involved in protein sorting; component of ER-SURF, a pathway involved in retrieving mitochondrial membrane protein precursors and rerouting them to the mitochondrial translocation system; promotes the proteolytic degradation of non-productive mitochondrial precursor proteins suggesting involvement in quality control during protein import; GFP-fusion protein localizes to the ER; member of a conserved family of ER proteins including human homolog TMEM97","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004040","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR050C"}


id: YLR051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04838":null,"YLR051C":null},"has_protein_features":false,"name":"FCF2","ortholog_annotations":[{"gene_uniquename":"YLR051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04838","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004041","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR051C"}


id: YLR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IES3","product":"Subunit of the INO80 chromatin remodeling complex","secondary_identifier":"SGD:S000004042","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR052W"}


id: YLR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NRS1","product":"Nitrogen-responsive activator of Start; nuclear microprotein with transcriptional activator activity; bypasses Start arrest in a cln3 bck2 double mutant when overexpressed; interacts with subunits of the SBF complex (Swi4p-Swi6p); induced by nitrogen limitation and rapamycin with peak abundance at Start; proposed to promote the G1/S transition by rewiring the G1/S transcriptional machinery under poor nitrogen conditions upstream of the Whi5-inhibited form of SBF and independent of Cln3 and Bck2","secondary_identifier":"SGD:S000004043","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR053C"}


id: YLR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OSW2","product":"Protein of unknown function reputedly involved in spore wall assembly","secondary_identifier":"SGD:S000004044","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR054C"}


id: YLR055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02066":null,"YLR055C":null},"has_protein_features":false,"name":"SPT8","ortholog_annotations":[{"gene_uniquename":"YLR055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02066","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SAGA transcriptional regulatory complex; not present in SAGA-like complex SLIK/SALSA; required for SAGA-mediated inhibition at some promoters","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004045","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR055C"}


id: YLR056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00717":null,"SJAG_03509":null,"YLR056W":null},"has_protein_features":false,"name":"ERG3","ortholog_annotations":[{"gene_uniquename":"YLR056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00717","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03509","reference_uniquename":"PMID:29761456"}],"product":"C-5 sterol desaturase; glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of HRD ubiquitin ligase; mutation is functionally complemented by human SC5D","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004046","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR056W"}


id: YLR057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MNL2","product":"Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene","secondary_identifier":"SGD:S000004047","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR057W"}


id: YLR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01766":null,"YLR058C":null},"has_protein_features":false,"name":"SHM2","ortholog_annotations":[{"gene_uniquename":"YLR058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01766","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004048","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR058C"}


id: YLR059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00401":null,"YLR059C":null},"has_protein_features":false,"name":"REX2","ortholog_annotations":[{"gene_uniquename":"YLR059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00401","reference_uniquename":"PMID:29761456"}],"product":"3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease; role in preventing L-A mycovirus pathogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004049","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR059C"}


id: YLR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02206":null,"YLR060W":null},"has_protein_features":false,"name":"FRS1","ortholog_annotations":[{"gene_uniquename":"YLR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02206","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004050","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR060W"}


id: YLR061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00220":null,"YLR061W":null},"has_protein_features":false,"name":"RPL22A","ortholog_annotations":[{"gene_uniquename":"YLR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00220","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L22A; required for translation of long 5' UTR of IME1 mRNA and meiotic entry; required for the oxidative stress response, pseudohyphal and invasive growth; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004051","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR061W"}


id: YLR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUD28","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay","secondary_identifier":"SGD:S000004052","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR062C"}


id: YLR063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BMT6","product":"Methyltransferase required for m3U2843 methylation of the 25S rRNA; S-adenosylmethionine-dependent; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene","secondary_identifier":"SGD:S000004053","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR063W"}


id: YLR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01460":null,"YLR064W":null},"has_protein_features":false,"name":"PER33","ortholog_annotations":[{"gene_uniquename":"YLR064W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01460","reference_uniquename":"PMID:29761456"}],"product":"Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004054","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR064W"}


id: YLR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03315":null,"YLR065C":null},"has_protein_features":false,"name":"SND2","ortholog_annotations":[{"gene_uniquename":"YLR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03315","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Pho88p/Snd3p and Sec61p-translocon subunits; can compensate for loss of SRP; role in the late endosome-vacuole interface; putative role in secretory protein quality control","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004055","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR065C"}


id: YLR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03737":null,"YLR066W":null},"has_protein_features":false,"name":"SPC3","ortholog_annotations":[{"gene_uniquename":"YLR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03737","reference_uniquename":"PMID:29761456"}],"product":"Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; other members of the complex are Spc1p, Spc2p, and Sec11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004056","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR066W"}


id: YLR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01249":null,"YLR067C":null},"has_protein_features":false,"name":"PET309","ortholog_annotations":[{"gene_uniquename":"YLR067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01249","reference_uniquename":"PMID:29761456"}],"product":"Specific translational activator for the COX1 mRNA; binds to the COX1 mRNA; also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains 12 pentatricopeptide repeats (PPRs)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004057","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR067C"}


id: YLR068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01250":null,"YLR068W":null},"has_protein_features":false,"name":"FYV7","ortholog_annotations":[{"gene_uniquename":"YLR068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01250","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004058","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR068W"}


id: YLR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02353":null,"YLR069C":null},"has_protein_features":false,"name":"MEF1","ortholog_annotations":[{"gene_uniquename":"YLR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02353","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial elongation factor involved in translational elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004059","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR069C"}


id: YLR070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00237":null,"YLR070C":null},"has_protein_features":false,"name":"XYL2","ortholog_annotations":[{"gene_uniquename":"YLR070C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00237","reference_uniquename":"PMID:29761456"}],"product":"Xylitol dehydrogenase; converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004060","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR070C"}


id: YLR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03573":null,"YLR071C":null},"has_protein_features":false,"name":"RGR1","ortholog_annotations":[{"gene_uniquename":"YLR071C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03573","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004061","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR071C"}


id: YLR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01329":null,"YLR072W":null},"has_protein_features":false,"name":"LAM6","ortholog_annotations":[{"gene_uniquename":"YLR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01329","reference_uniquename":"PMID:29761456"}],"product":"Sterol transporter that transfers sterols between membranes; may regulate and coordinate formation of contact sites between organelles; localizes to ER-mitochondrial contact sites in a Tom70p- and Tom71p-dependent manner; mitochondrial localization requires GRAM domain; also localizes to ER-vacuole contact sites, in a Vac8p-dependent manner; has GRAM and StART-like (VASt) domains; one of six StART-like domain-containing proteins in yeast; conserved across eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004062","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR072W"}


id: YLR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RFU1","product":"Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes","secondary_identifier":"SGD:S000004063","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR073C"}


id: YLR074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01280":null,"YLR074C":null},"has_protein_features":false,"name":"BUD20","ortholog_annotations":[{"gene_uniquename":"YLR074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01280","reference_uniquename":"PMID:29761456"}],"product":"C2H2-type zinc finger protein required for ribosome assembly; shuttling factor which associates with pre-60S particles in the nucleus, accompanying them to the cytoplasm; cytoplasmic dissociation of Bud20p requires Drg1p; N-terminus harbors a nuclear localization signal (NLS) and a nuclear export signal (NES); cytoplasmic Bud20p is reimported by Kap123-dependent pathway; involved in bud-site selection; diploid mutants display a random budding pattern; similar to human ZNF593","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004064","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR074C"}


id: YLR075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04176":null,"YLR075W":null},"has_protein_features":false,"name":"RPL10","ortholog_annotations":[{"gene_uniquename":"YLR075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04176","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L10; homologous to mammalian ribosomal protein L10 and bacterial L16; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; protein abundance increases under DNA replication stress; mutations in human homolog implicated in T-cell acute lymphoblastic leukemia and also autism spectrum disorders (ASD); human RPL10 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004065","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR075W"}


id: YLR076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10","secondary_identifier":"SGD:S000004066","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR076C"}


id: YLR077W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMP25","product":"Protein required for assembly of respiratory complex III; mitochondrial inner membrane protein; required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria","secondary_identifier":"SGD:S000004067","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR077W"}


id: YLR078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04513":null,"YLR078C":null},"has_protein_features":false,"name":"BOS1","ortholog_annotations":[{"gene_uniquename":"YLR078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04513","reference_uniquename":"PMID:29761456"}],"product":"v-SNARE (vesicle specific SNAP receptor); localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi; required for efficient nuclear fusion during mating","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004068","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR078C"}


id: YLR079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SIC1","product":"Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylated by Clb5/6-Cdk1 and Cln1/2-Cdk1 kinase which regulate timing of Sic1p degradation; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1","secondary_identifier":"SGD:S000004069","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR079W"}


id: YLR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02839":null,"YLR080W":null},"has_protein_features":false,"name":"EMP46","ortholog_annotations":[{"gene_uniquename":"YLR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02839","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane component of ER-derived COPII-coated vesicles; functions in ER to Golgi transport; EMP46 has a paralog, EMP47, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004070","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR080W"}


id: YLR081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YLR081W":null},"has_protein_features":false,"name":"GAL2","ortholog_annotations":[{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Galactose permease; required for utilization of galactose; also able to transport glucose","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004071","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR081W"}


id: YLR082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SRL2","product":"Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation","secondary_identifier":"SGD:S000004072","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR082C"}


id: YLR083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00299":null,"YLR083C":null},"has_protein_features":false,"name":"EMP70","ortholog_annotations":[{"gene_uniquename":"YLR083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00299","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in cellular adhesion and filamentous growth; also endosome-to-vacuole sorting; similar to Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; EMP70 has a paralog, TMN2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004073","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR083C"}


id: YLR084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01388":null,"YLR084C":null},"has_protein_features":false,"name":"RAX2","ortholog_annotations":[{"gene_uniquename":"YLR084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01388","reference_uniquename":"PMID:29761456"}],"product":"Protein required for the maintenance of bud site selection; localizes; localization to the bud neck and previous sites of cell division (bud scars; cytokinesis remnants (CRMs)) is interdependent with Rax2p; required with Rax1p to anchor both Nba1p and Nis1p to CRMs where a Cdc42p inhibitory zone is established preventing repolarization of cells at previous division sites; RAX2 mRNA stability is regulated by Mpt5p; predicted type I membrane-spanning protein; N-glycosylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004074","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR084C"}


id: YLR085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03694":null,"YLR085C":null},"has_protein_features":false,"name":"ARP6","ortholog_annotations":[{"gene_uniquename":"YLR085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03694","reference_uniquename":"PMID:29761456"}],"product":"Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004075","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR085C"}


id: YLR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00871":null,"YLR086W":null},"has_protein_features":false,"name":"SMC4","ortholog_annotations":[{"gene_uniquename":"YLR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00871","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004076","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR086W"}


id: YLR087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSF1","product":"Protein with structural similarity to lipid transport protein Vps13p; localizes to multiple membrane contact sites between organelles; role in phospholipid homeostasis and lipidomic adaptation to cold; required for fermentation at low temperature; plays a role in phosphatidylethanolamine metabolism and secretory protein maturation; non-tagged protein is detected in highly purified mitochondria in HTP studies","secondary_identifier":"SGD:S000004077","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR087C"}


id: YLR088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03292":null,"YLR088W":null},"has_protein_features":false,"name":"GAA1","ortholog_annotations":[{"gene_uniquename":"YLR088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03292","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the GPI:protein transamidase complex; removes the GPI-anchoring signal and attaches GPI (glycosylphosphatidylinositol) to proteins in the ER; human homolog GPAA1 can complement growth defects of yeast thermosensitive mutant at restrictive temperature","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004078","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR088W"}


id: YLR089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04145":null,"YLR089C":null},"has_protein_features":false,"name":"ALT1","ortholog_annotations":[{"gene_uniquename":"YLR089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04145","reference_uniquename":"PMID:29761456"}],"product":"Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthesis and catabolism; TOR1-independent role in determining chronological lifespan; expression is induced in the presence of alanine; repression is mediated by Nrg1p; ALT1 has a paralog, ALT2, that arose from the whole genome duplication; Alt2p is catalytically inactive","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004079","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR089C"}


id: YLR090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03135":null,"YLR090W":null},"has_protein_features":false,"name":"XDJ1","ortholog_annotations":[{"gene_uniquename":"YLR090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03135","reference_uniquename":"PMID:29761456"}],"product":"Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004080","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR090W"}


id: YLR091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GEP5","product":"Protein of unknown function; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine; localizes to the matrix side of the inner mitochondrial membrane","secondary_identifier":"SGD:S000004081","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR091W"}


id: YLR092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02463":null,"YLR092W":null},"has_protein_features":false,"name":"SUL2","ortholog_annotations":[{"gene_uniquename":"YLR092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02463","reference_uniquename":"PMID:29761456"}],"product":"High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004082","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR092W"}


id: YLR093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NYV1","product":"v-SNARE component of vacuolar SNARE complex; involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in vacuolar membrane; targeted to vacuole via AP-3 pathway","secondary_identifier":"SGD:S000004083","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR093C"}


id: YLR094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GIS3","product":"Protein of unknown function","secondary_identifier":"SGD:S000004084","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR094C"}


id: YLR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IOC2","product":"Subunit of the Isw1b complex; exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing; contains a PHD finger motif; other complex members are Isw1p and Ioc4p","secondary_identifier":"SGD:S000004085","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR095C"}


id: YLR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02838":null,"YLR096W":null},"has_protein_features":false,"name":"KIN2","ortholog_annotations":[{"gene_uniquename":"YLR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02838","reference_uniquename":"PMID:29761456"}],"product":"S/T protein kinase; regulates polarized exocytosis and the Ire1p-mediated UPR; regulates HAC1 mRNA translocation, splicing and translation with KIN1 during ER stress; direct phosphorylation of Sec9p (S190) is enhanced by prior substrate priming (S192); localizes to the cytoplasmic face of the PM and sites of polarized growth; may regulate septin and cell wall organization; activation loop phosphorylation (T281) required for full kinase activity; orthologous to MARK/PAR-1, AMPK family members","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004086","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR096W"}


id: YLR097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03651":null,"YLR097C":null},"has_protein_features":false,"name":"HRT3","ortholog_annotations":[{"gene_uniquename":"YLR097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03651","reference_uniquename":"PMID:29761456"}],"product":"Putative SCF-ubiquitin ligase F-box protein; based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004087","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR097C"}


id: YLR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05337":null,"YLR098C":null},"has_protein_features":false,"name":"CHA4","ortholog_annotations":[{"gene_uniquename":"YLR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05337","reference_uniquename":"PMID:29761456"}],"product":"DNA binding transcriptional activator; mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004088","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR098C"}


id: YLR099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ICT1","product":"Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication; human ABHD5 can complement ict1 null mutant","secondary_identifier":"SGD:S000004089","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR099C"}


id: YLR099W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02361":null,"YLR099W-A":null},"has_protein_features":false,"name":"MIM2","ortholog_annotations":[{"gene_uniquename":"YLR099W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02361","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for outer membrane protein import; involved in import of the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and Fzo1p; component of a large protein complex in the outer membrane that includes Mim1p and functions as cation-selective channel for translocation of positively charged precursor segments; not essential in W303 strain background","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007618","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR099W-A"}


id: YLR100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03235":null,"YLR100W":null},"has_protein_features":false,"name":"ERG27","ortholog_annotations":[{"gene_uniquename":"YLR100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03235","reference_uniquename":"PMID:29761456"}],"product":"3-keto sterol reductase; catalyzes last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; Erg27 protein is mainly ER-localized in strains devoid of mtDNA (rho° cells); mutants are sterol auxotrophs; mutation is functionally complemented by human HSD17B7","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004090","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR100W"}


id: YLR101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W","secondary_identifier":"SGD:S000004091","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR101C"}


id: YLR102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"APC9","product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition","secondary_identifier":"SGD:S000004092","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR102C"}


id: YLR103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00327":null,"YLR103C":null},"has_protein_features":false,"name":"CDC45","ortholog_annotations":[{"gene_uniquename":"YLR103C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00327","reference_uniquename":"PMID:29761456"}],"product":"DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004093","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR103C"}


id: YLR104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LCL2","product":"Putative protein of unknown function; mutant is deficient in cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD); SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole","secondary_identifier":"SGD:S000004094","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR104W"}


id: YLR105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03328":null,"YLR105C":null},"has_protein_features":false,"name":"SEN2","ortholog_annotations":[{"gene_uniquename":"YLR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03328","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease; localizes to the peroxisome in a Pex5p-dependent manner in oleate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004095","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR105C"}


id: YLR106C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03496":null,"YLR106C":null},"has_protein_features":false,"name":"REA1","ortholog_annotations":[{"gene_uniquename":"YLR106C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03496","reference_uniquename":"PMID:29761456"}],"product":"Huge dynein-related AAA-type ATPase (midasin); forms extended pre-60S particle with the Rix1 complex; involved with interaction partners Rsa4p and Ytm1p, in the ATP-dependent remodeling of the pre-60S particle at successive maturation steps during ribosomal biogenesis; involved in the removal of biogenesis factors including GTPase Nog2p prior to nuclear export; contains a hexameric AAA-motor head domain and a long flexible tail with a MIDAS (metal ion-dependent adhesion site) domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004096","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR106C"}


id: YLR107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00081":null,"YLR107W":null},"has_protein_features":false,"name":"REX3","ortholog_annotations":[{"gene_uniquename":"YLR107W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00081","reference_uniquename":"PMID:29761456"}],"product":"RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004097","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR107W"}


id: YLR108C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004098","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR108C"}


id: YLR109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03166":null,"YLR109W":null},"has_protein_features":false,"name":"AHP1","ortholog_annotations":[{"gene_uniquename":"YLR109W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03166","reference_uniquename":"PMID:29761456"}],"product":"Thiol-specific peroxiredoxin; reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004099","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR109W"}


id: YLR110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CCW12","product":"Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004100","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR110C"}


id: YLR111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000004101","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR111W"}


id: YLR112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000004102","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR112W"}


id: YLR113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02592":null,"YLR113W":null},"has_protein_features":false,"name":"HOG1","ortholog_annotations":[{"gene_uniquename":"YLR113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02592","reference_uniquename":"PMID:29761456"}],"product":"Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004103","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR113W"}


id: YLR114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02443":null,"YLR114C":null},"has_protein_features":false,"name":"AVL9","ortholog_annotations":[{"gene_uniquename":"YLR114C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02443","reference_uniquename":"PMID:29761456"}],"product":"Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004104","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR114C"}


id: YLR115W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03226":null,"YLR115W":null},"has_protein_features":false,"name":"CFT2","ortholog_annotations":[{"gene_uniquename":"YLR115W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03226","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004105","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR115W"}


id: YLR116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00249":null,"YLR116W":null},"has_protein_features":false,"name":"MSL5","ortholog_annotations":[{"gene_uniquename":"YLR116W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00249","reference_uniquename":"PMID:29761456"}],"product":"Component of commitment complex; which defines first step in splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004106","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR116W"}


id: YLR117C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00911":null,"YLR117C":null},"has_protein_features":false,"name":"CLF1","ortholog_annotations":[{"gene_uniquename":"YLR117C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00911","reference_uniquename":"PMID:29761456"}],"product":"Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004107","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR117C"}


id: YLR118C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02268":null,"YLR118C":null},"has_protein_features":false,"name":"TML25","ortholog_annotations":[{"gene_uniquename":"YLR118C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02268","reference_uniquename":"PMID:29761456"}],"product":"Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004108","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR118C"}


id: YLR119W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SRN2","product":"Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus","secondary_identifier":"SGD:S000004109","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR119W"}


id: YLR120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00109":null,"SJAG_00254":null,"SJAG_00784":null,"SJAG_02260":null,"YLR120C":null},"has_protein_features":false,"name":"YPS1","ortholog_annotations":[{"gene_uniquename":"YLR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00109","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00254","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00784","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02260","reference_uniquename":"PMID:29761456"}],"product":"Aspartic protease; hyperglycosylated member of the yapsin family of proteases, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; involved in nutrient limitation-induced cleavage of the extracellular inhibitory domain of signaling mucin Msb2p, resulting in activation of the filamentous growth MAPK pathway; involved with other yapsins in the cell wall integrity response; role in KEX2-independent processing of the alpha factor precursor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004110","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR120C"}


id: YLR120W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR121C","secondary_identifier":"SGD:S000028674","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR120W-A"}


id: YLR121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00109":null,"SJAG_00254":null,"SJAG_00784":null,"SJAG_02260":null,"YLR121C":null},"has_protein_features":false,"name":"YPS3","ortholog_annotations":[{"gene_uniquename":"YLR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00109","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00254","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00784","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02260","reference_uniquename":"PMID:29761456"}],"product":"Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004111","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR121C"}


id: YLR122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; partially overlaps dubious ORF YLR123C","secondary_identifier":"SGD:S000004112","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR122C"}


id: YLR123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif","secondary_identifier":"SGD:S000004113","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR123C"}


id: YLR124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004114","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR124W"}


id: YLR125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene","secondary_identifier":"SGD:S000004115","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR125W"}


id: YLR126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00811":null,"YLR126C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR126C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00811","reference_uniquename":"PMID:29761456"}],"product":"Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004116","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR126C"}


id: YLR127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03575":null,"YLR127C":null},"has_protein_features":false,"name":"APC2","ortholog_annotations":[{"gene_uniquename":"YLR127C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03575","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004117","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR127C"}


id: YLR128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00033":null,"YLR128W":null},"has_protein_features":false,"name":"DCN1","ortholog_annotations":[{"gene_uniquename":"YLR128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00033","reference_uniquename":"PMID:29761456"}],"product":"Scaffold-type E3 ligase; required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004118","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR128W"}


id: YLR129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02300":null,"YLR129W":null},"has_protein_features":false,"name":"DIP2","ortholog_annotations":[{"gene_uniquename":"YLR129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02300","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004119","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR129W"}


id: YLR130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04185":null,"YLR130C":null},"has_protein_features":false,"name":"ZRT2","ortholog_annotations":[{"gene_uniquename":"YLR130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04185","reference_uniquename":"PMID:29761456"}],"product":"Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004120","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR130C"}


id: YLR131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02252":null,"YLR131C":null},"has_protein_features":false,"name":"ACE2","ortholog_annotations":[{"gene_uniquename":"YLR131C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02252","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor required for septum destruction after cytokinesis; part of the RAM network that regulates polarity and morphogenesis; NES phosphorylation by RAM network kinase Cbk1p blocks nuclear exit in mother cells during the M/G1 transition, causing asymmetric localization to daughter cell nuclei, and increased Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; Spt16p is required for nuclear exclusion during G1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004121","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR131C"}


id: YLR132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01798":null,"YLR132C":null},"has_protein_features":false,"name":"USB1","ortholog_annotations":[{"gene_uniquename":"YLR132C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01798","reference_uniquename":"PMID:29761456"}],"product":"Putative poly(U)-specific 3'-to-5' RNA exonuclease; involved in 3'-end processing of U6 snRNA removing uridines and generating a terminal 2&#8242;,3&#8242; cyclic phosphate; essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants; homolog of S.pombe gene, mpn1 and human gene, hUSB1; mutations in hUSB1 are associated with a rare genodermatosis, poikiloderma with neutropenia (OMIM 604173)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004122","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR132C"}


id: YLR133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01918":null,"YLR133W":null},"has_protein_features":false,"name":"CKI1","ortholog_annotations":[{"gene_uniquename":"YLR133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01918","reference_uniquename":"PMID:29761456"}],"product":"Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004123","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR133W"}


id: YLR134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02734":null,"SJAG_03743":null,"SJAG_04842":null,"YLR134W":null},"has_protein_features":false,"name":"PDC5","ortholog_annotations":[{"gene_uniquename":"YLR134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02734","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03743","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04842","reference_uniquename":"PMID:29761456"}],"product":"Minor isoform of pyruvate decarboxylase; key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004124","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR134W"}


id: YLR135W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05180":null,"YLR135W":null},"has_protein_features":false,"name":"SLX4","ortholog_annotations":[{"gene_uniquename":"YLR135W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05180","reference_uniquename":"PMID:29761456"}],"product":"Endonuclease involved in processing DNA; acts during recombination, repair; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); cleaves branched structures in complex with Slx1p; involved in interstrand cross-link repair, Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress; FANCP-related factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004125","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR135W"}


id: YLR136C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04682":null,"YLR136C":null},"has_protein_features":false,"name":"TIS11","ortholog_annotations":[{"gene_uniquename":"YLR136C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04682","reference_uniquename":"PMID:29761456"}],"product":"mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; represses mitochondrial function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; TIS11 has a paralog, CTH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004126","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR136C"}


id: YLR137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RKM5","product":"Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species","secondary_identifier":"SGD:S000004127","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR137W"}


id: YLR138W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01541":null,"YLR138W":null},"has_protein_features":false,"name":"NHA1","ortholog_annotations":[{"gene_uniquename":"YLR138W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01541","reference_uniquename":"PMID:29761456"}],"product":"Na+/H+ antiporter; involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004128","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR138W"}


id: YLR139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04929":null,"YLR139C":null},"has_protein_features":false,"name":"SLS1","ortholog_annotations":[{"gene_uniquename":"YLR139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04929","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial membrane protein; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004129","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR139C"}


id: YLR140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I","secondary_identifier":"SGD:S000004130","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR140W"}


id: YLR141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04766":null,"YLR141W":null},"has_protein_features":false,"name":"RRN5","ortholog_annotations":[{"gene_uniquename":"YLR141W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04766","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004131","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR141W"}


id: YLR142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01903":null,"YLR142W":null},"has_protein_features":false,"name":"PUT1","ortholog_annotations":[{"gene_uniquename":"YLR142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01903","reference_uniquename":"PMID:29761456"}],"product":"Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004132","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR142W"}


id: YLR143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04544":null,"YLR143W":null},"has_protein_features":false,"name":"DPH6","ortholog_annotations":[{"gene_uniquename":"YLR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04544","reference_uniquename":"PMID:29761456"}],"product":"Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004133","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR143W"}


id: YLR144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00667":null,"SJAG_01017":null,"YLR144C":null},"has_protein_features":false,"name":"ACF2","ortholog_annotations":[{"gene_uniquename":"YLR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00667","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01017","reference_uniquename":"PMID:29761456"}],"product":"Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004134","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR144C"}


id: YLR145W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03952":null,"YLR145W":null},"has_protein_features":false,"name":"RMP1","ortholog_annotations":[{"gene_uniquename":"YLR145W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03952","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNase MRP; RNase MRP processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004135","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR145W"}


id: YLR146C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04481":null,"YLR146C":null},"has_protein_features":false,"name":"SPE4","ortholog_annotations":[{"gene_uniquename":"YLR146C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04481","reference_uniquename":"PMID:29761456"}],"product":"Spermine synthase; required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004136","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR146C"}


id: YLR146W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function","secondary_identifier":"SGD:S000113566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR146W-A"}


id: YLR147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01301":null,"YLR147C":null},"has_protein_features":false,"name":"SMD3","ortholog_annotations":[{"gene_uniquename":"YLR147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01301","reference_uniquename":"PMID:29761456"}],"product":"Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004137","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR147C"}


id: YLR148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03005":null,"YLR148W":null},"has_protein_features":false,"name":"PEP3","ortholog_annotations":[{"gene_uniquename":"YLR148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03005","reference_uniquename":"PMID:29761456"}],"product":"Component of CORVET membrane tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004138","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR148W"}


id: YLR149C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04170":null,"YLR149C":null},"has_protein_features":false,"name":"GID11","ortholog_annotations":[{"gene_uniquename":"YLR149C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04170","reference_uniquename":"PMID:29761456"}],"product":"Substrate receptor of the glucose-induced degradation-deficient (GID) complex that targets gluconeogenic enzymes for proteasomal degradation upon switch from ethanol to glucose as a carbon source; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004139","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR149C"}


id: YLR149C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR149C-A"}


id: YLR150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04383":null,"YLR150W":null},"has_protein_features":false,"name":"STM1","ortholog_annotations":[{"gene_uniquename":"YLR150W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04383","reference_uniquename":"PMID:29761456"}],"product":"Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004140","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR150W"}


id: YLR151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02247":null,"YLR151C":null},"has_protein_features":false,"name":"PCD1","ortholog_annotations":[{"gene_uniquename":"YLR151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02247","reference_uniquename":"PMID:29761456"}],"product":"8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004141","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR151C"}


id: YLR152C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YLR152C is not an essential gene","secondary_identifier":"SGD:S000004142","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR152C"}


id: YLR153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02741":null,"YLR153C":null},"has_protein_features":false,"name":"ACS2","ortholog_annotations":[{"gene_uniquename":"YLR153C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02741","reference_uniquename":"PMID:29761456"}],"product":"Acetyl-coA synthetase isoform; along with Acs1p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004143","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR153C"}


id: YLR154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01884":null,"YLR154C":null},"has_protein_features":false,"name":"RNH203","ortholog_annotations":[{"gene_uniquename":"YLR154C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01884","reference_uniquename":"PMID:29761456"}],"product":"Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS3 that causes Aicardi-Goutieres syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004144","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154C"}


id: YLR154C-G
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-2","secondary_identifier":"SGD:S000028561","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154C-G"}


id: YLR154C-H
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-2; YLR154C-H has a paralog, YLR157C-C, that arose from a segmental duplication","secondary_identifier":"SGD:S000028562","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154C-H"}


id: YLR154W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 25S rRNA gene on the opposite strand","secondary_identifier":"SGD:S000028675","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154W-A"}


id: YLR154W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 25S rRNA gene on the opposite strand","secondary_identifier":"SGD:S000028563","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154W-B"}


id: YLR154W-C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TAR1","product":"Protein potentially involved in regulation of respiratory metabolism; located in the mitochondria; interacts genetically with RPO41 and physically with Coq5p; encoded within the 25S rRNA gene on the opposite strand","secondary_identifier":"SGD:S000028422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154W-C"}


id: YLR154W-E
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 35S rRNA gene on the opposite strand","secondary_identifier":"SGD:S000028676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154W-E"}


id: YLR154W-F
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 35S rRNA gene on the opposite strand","secondary_identifier":"SGD:S000028843","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154W-F"}


id: YLR155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ASP3-1","product":"Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from wine yeast Wickerhamomyces anomalus or close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-1 has paralog ASP3-3 that arose from a segmental duplication","secondary_identifier":"SGD:S000004145","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR155C"}


id: YLR156C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; partially overlaps RND5-3; YLR156C-A has a paralog, YLR159C-A, that arose from a segmental duplication","secondary_identifier":"SGD:S000028564","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR156C-A"}


id: YLR156W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; exhibits a two-hybrid interaction with Jsn1p in a large-scale analysis; YLR156W has a paralog, YLR159W, that arose from a segmental duplication","secondary_identifier":"SGD:S000004146","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR156W"}


id: YLR157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ASP3-2","product":"Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-2 has a paralog, ASP3-4, that arose from a segmental duplication","secondary_identifier":"SGD:S000004147","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR157C"}


id: YLR157C-C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-4; YLR157C-C has a paralog, YLR154C-H, that arose from a segmental duplication","secondary_identifier":"SGD:S000028565","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR157C-C"}


id: YLR157W-D
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; YLR157W-D has a paralog, YLR161W, that arose from a segmental duplication","secondary_identifier":"SGD:S000028677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR157W-D"}


id: YLR157W-E
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function identified by gene-trapping; microarray-based expression analysis, and genome-wide homology searching; partially overlaps a Ty1 element","secondary_identifier":"SGD:S000028678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR157W-E"}


id: YLR158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ASP3-3","product":"Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-3 has a paralog, ASP3-1, that arose from a segmental duplication","secondary_identifier":"SGD:S000004148","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR158C"}


id: YLR159C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; partially overlaps RND5-5; YLR159C-A has a paralog, YLR156C-A, that arose from a segmental duplication","secondary_identifier":"SGD:S000028566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR159C-A"}


id: YLR159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames in S288C encoded near the ribosomal DNA region of chromosome 12; YLR159W has a paralog, YLR156W, that arose from a segmental duplication","secondary_identifier":"SGD:S000004149","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR159W"}


id: YLR160C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ASP3-4","product":"Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-4 has a paralog, ASP3-2, that arose from a segmental duplication","secondary_identifier":"SGD:S000004150","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR160C"}


id: YLR161W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames in S288C encoded near the ribosomal DNA region of chromosome 12; YLR161W has a paralog, YLR157W-D, that arose from a segmental duplication","secondary_identifier":"SGD:S000004151","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR161W"}


id: YLR162W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; overexpression confers resistance to the antimicrobial peptide MiAMP1 and causes growth arrest, apoptosis, and increased sensitivity to cobalt chloride","secondary_identifier":"SGD:S000004152","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR162W"}


id: YLR162W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRT15","product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; identified in a screen for mutants with decreased levels of rDNA transcription","secondary_identifier":"SGD:S000028567","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR162W-A"}


id: YLR163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02397":null,"YLR163C":null},"has_protein_features":false,"name":"MAS1","ortholog_annotations":[{"gene_uniquename":"YLR163C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02397","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004153","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR163C"}


id: YLR163W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000028844","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR163W-A"}


id: YLR164W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02398":null,"YLR164W":null},"has_protein_features":false,"name":"SHH4","ortholog_annotations":[{"gene_uniquename":"YLR164W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02398","reference_uniquename":"PMID:29761456"}],"product":"Putative alternate subunit of succinate dehydrogenase (SDH); mitochondrial inner membrane protein; genetic interaction with SDH4 suggests that Shh4p can function as a functional SDH subunit; a fraction copurifies with SDH subunit Sdh3p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner; Shh4p has greater similarity to human SDHD (subunit D of SDH, implicated in paraganglioma) than does its paralog Sdh4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004154","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR164W"}


id: YLR165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PUS5","product":"Pseudouridine synthase; catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability","secondary_identifier":"SGD:S000004155","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR165C"}


id: YLR166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04044":null,"YLR166C":null},"has_protein_features":false,"name":"SEC10","ortholog_annotations":[{"gene_uniquename":"YLR166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04044","reference_uniquename":"PMID:29761456"}],"product":"Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004156","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR166C"}


id: YLR167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01226":null,"SJAG_02253":null,"YLR167W":null},"has_protein_features":false,"name":"RPS31","ortholog_annotations":[{"gene_uniquename":"YLR167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01226","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02253","reference_uniquename":"PMID:29761456"}],"product":"Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004157","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR167W"}


id: YLR168C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00576":null,"YLR168C":null},"has_protein_features":false,"name":"UPS2","ortholog_annotations":[{"gene_uniquename":"YLR168C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00576","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial intermembrane space protein; involved in phospholipid metabolism; forms complex with Mdm35p that transfers phosphatidylserine from outer membrane to inner membrane for phosphatidylethanolamine synthesis; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI; UPS2 has a paralog, UPS3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004158","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR168C"}


id: YLR169W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004159","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR169W"}


id: YLR170C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00379":null,"YLR170C":null},"has_protein_features":false,"name":"APS1","ortholog_annotations":[{"gene_uniquename":"YLR170C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00379","reference_uniquename":"PMID:29761456"}],"product":"Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004160","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR170C"}


id: YLR171W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004161","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR171W"}


id: YLR172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02467":null,"YLR172C":null},"has_protein_features":false,"name":"DPH5","ortholog_annotations":[{"gene_uniquename":"YLR172C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02467","reference_uniquename":"PMID:29761456"}],"product":"Methyltransferase required for synthesis of diphthamide; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004162","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR172C"}


id: YLR173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TAG1","product":"Vacuolar membrane protein involved in termination of autophagy; regulates autophagy termination during persistent nitrogen starvation through Atg1p-mediated re-phosphorylation of Atg13p and PAS disassembly; type II membrane protein containing hydrophobic transmembrane region with N-terminal region oriented toward cytosol and C-terminus inside lumen; luminal domain is glycosylated; forms foci in vacuole membrane during starvation; targeted to vacuole via AP-3 pathway","secondary_identifier":"SGD:S000004163","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR173W"}


id: YLR174W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04362":null,"YLR174W":null},"has_protein_features":false,"name":"IDP2","ortholog_annotations":[{"gene_uniquename":"YLR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04362","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication; mutation in human homolog IDH1 is associated with low-grade gliomas and secondary glioblastomas","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004164","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR174W"}


id: YLR175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04754":null,"YLR175W":null},"has_protein_features":false,"name":"CBF5","ortholog_annotations":[{"gene_uniquename":"YLR175W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04754","reference_uniquename":"PMID:29761456"}],"product":"Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs; acts on large and small rRNAs, on snRNA U2, and on some mRNAs; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita; small nucleolar ribonucleoprotein particles are also known as snoRNPs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004165","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR175W"}


id: YLR176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04839":null,"YLR176C":null},"has_protein_features":false,"name":"RFX1","ortholog_annotations":[{"gene_uniquename":"YLR176C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04839","reference_uniquename":"PMID:29761456"}],"product":"Major transcriptional repressor of DNA-damage-regulated genes; recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004166","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR176C"}


id: YLR177W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04686":null,"YLR177W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04686","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004167","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR177W"}


id: YLR178C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TFS1","product":"Inhibitor of carboxypeptidase Y (Prc1p), and Ras GAP (Ira2p); phosphatidylethanolamine-binding protein (PEBP) family member and ortholog of hPEBP1/RKIP, a natural metastasis suppressor; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004168","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR178C"}


id: YLR179C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus","secondary_identifier":"SGD:S000004169","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR179C"}


id: YLR180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03659":null,"YLR180W":null},"has_protein_features":false,"name":"SAM1","ortholog_annotations":[{"gene_uniquename":"YLR180W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03659","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004170","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR180W"}


id: YLR181C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04047":null,"YLR181C":null},"has_protein_features":false,"name":"VTA1","ortholog_annotations":[{"gene_uniquename":"YLR181C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04047","reference_uniquename":"PMID:29761456"}],"product":"Multivesicular body (MVB) protein; involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004171","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR181C"}


id: YLR182W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02810":null,"YLR182W":null},"has_protein_features":false,"name":"SWI6","ortholog_annotations":[{"gene_uniquename":"YLR182W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02810","reference_uniquename":"PMID:29761456"}],"product":"Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004172","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR182W"}


id: YLR183C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04512":null,"YLR183C":null},"has_protein_features":false,"name":"TOS4","ortholog_annotations":[{"gene_uniquename":"YLR183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04512","reference_uniquename":"PMID:29761456"}],"product":"Putative transcription factor, contains Forkhead Associated domain; binds chromatin; involved in expression homeostasis, buffering of mRNA synthesis rate against gene dosage changes during S phase; target of SBF transcription factor; expression is periodic and peaks in G1; involved in DNA replication checkpoint response; interacts with Rpd3 and Set3 histone deacetylase complexes; APCC(Cdh1) substrate; relative distribution to nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004173","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR183C"}


id: YLR184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004174","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR184W"}


id: YLR185W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01194":null,"SJAG_03326":null,"YLR185W":null},"has_protein_features":false,"name":"RPL37A","ortholog_annotations":[{"gene_uniquename":"YLR185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01194","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03326","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L37A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004175","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR185W"}


id: YLR186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02024":null,"YLR186W":null},"has_protein_features":false,"name":"EMG1","ortholog_annotations":[{"gene_uniquename":"YLR186W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02024","reference_uniquename":"PMID:29761456"}],"product":"Methyltransferase for rRNA; methylates pseudouridine 18S rRNA residue 1191; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independent of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and equivalent yeast mutation affects Emg1p dimerization and localization but not methyltransferase activity; human EMG1 complements lethality of null and ts mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004176","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR186W"}


id: YLR187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SKG3","product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004177","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR187W"}


id: YLR188W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MDL1","product":"Mitochondrial inner membrane half-type ABC transporter; mediates export of peptides generated upon proteolysis of mitochondrial proteins; plays a role in the regulation of cellular resistance to oxidative stress","secondary_identifier":"SGD:S000004178","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR188W"}


id: YLR189C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG26","product":"UDP-glucose:sterol glucosyltransferase; conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy","secondary_identifier":"SGD:S000004179","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR189C"}


id: YLR190W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MMR1","product":"Phospholipid binding protein; interacts with mitochondria and with Myo2p, functioning as an adaptor that recruits Myo2p and facilitates actin-based transport of mitochondria to the bud; mediates mitochondria anchorage at the bud tip; phosphorylated protein that localizes to the mitochondrial outer membrane; mRNA is targeted to the bud via the transport system involving She2p; member of the DSL1 family of tethering proteins","secondary_identifier":"SGD:S000004180","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR190W"}


id: YLR191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02693":null,"YLR191W":null},"has_protein_features":false,"name":"PEX13","ortholog_annotations":[{"gene_uniquename":"YLR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02693","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal importomer complex component; integral peroxisomal membrane protein required for docking and translocation of peroxisomal matrix proteins; interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p; forms a complex with Pex14p and Pex17p; human homolog PEX13 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004181","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR191W"}


id: YLR192C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04900":null,"YLR192C":null},"has_protein_features":false,"name":"HCR1","ortholog_annotations":[{"gene_uniquename":"YLR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04900","reference_uniquename":"PMID:29761456"}],"product":"eIF3j component of translation initiation factor 3 (eIF3); role in initiation as a substoichiometric component of eIF3; 60S ribosomal subunit recycling accessory factor; involved in nonsense-mediated mRNA decay (NMD); required for 20S pre-rRNA processing; post-transcriptional role in retrotransposition; absence decreases Ty1 Gag protein levels; binds eIF3 subunits Rpg1p, Prt1p and 18S rRNA; eIF3 promotes programmed stop codon readthrough; human homolog EIF3J can complement a yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004182","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR192C"}


id: YLR193C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00230":null,"YLR193C":null},"has_protein_features":false,"name":"UPS1","ortholog_annotations":[{"gene_uniquename":"YLR193C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00230","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004183","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR193C"}


id: YLR194C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NCW2","product":"GPI-anchored protein involved in cell wall remodeling; involved in the assembly of the cell wall chitin-glucan structure and repair of damage caused by the antifungal agent polyhexamethylene biguanide; role in the cell wall integrity pathway; expression is upregulated in response to cell wall stress; transported to the cell surface after Pmt1p-Pmt2p-mediated O-mannosylation, colocalizing with bud scars","secondary_identifier":"SGD:S000004184","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR194C"}


id: YLR195C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00102":null,"YLR195C":null},"has_protein_features":false,"name":"NMT1","ortholog_annotations":[{"gene_uniquename":"YLR195C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00102","reference_uniquename":"PMID:29761456"}],"product":"N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004185","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR195C"}


id: YLR196W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01153":null,"YLR196W":null},"has_protein_features":false,"name":"PWP1","ortholog_annotations":[{"gene_uniquename":"YLR196W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01153","reference_uniquename":"PMID:29761456"}],"product":"Protein with WD-40 repeats involved in rRNA processing; associates with rDNA chromatin in H4-tail-dependent manner; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004186","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR196W"}


id: YLR197W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02377":null,"YLR197W":null},"has_protein_features":false,"name":"NOP56","ortholog_annotations":[{"gene_uniquename":"YLR197W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02377","reference_uniquename":"PMID:29761456"}],"product":"Essential evolutionarily-conserved nucleolar protein; component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004187","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR197W"}


id: YLR198C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W","secondary_identifier":"SGD:S000004188","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR198C"}


id: YLR199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PBA1","product":"Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly","secondary_identifier":"SGD:S000004189","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR199C"}


id: YLR200W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01545":null,"YLR200W":null},"has_protein_features":false,"name":"YKE2","ortholog_annotations":[{"gene_uniquename":"YLR200W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01545","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the heterohexameric Gim/prefoldin protein complex; involved in the folding of alpha-tubulin, beta-tubulin, and actin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004190","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR200W"}


id: YLR201C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01866":null,"YLR201C":null},"has_protein_features":false,"name":"COQ9","ortholog_annotations":[{"gene_uniquename":"YLR201C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01866","reference_uniquename":"PMID:29761456"}],"product":"Protein required for ubiquinone biosynthesis and respiratory growth; localizes to matrix face of mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; ubiquinone is also known as coenzyme Q; human homolog COQ9 can complement yeast coq9 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004191","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR201C"}


id: YLR202C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron","secondary_identifier":"SGD:S000004192","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR202C"}


id: YLR203C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02979":null,"YLR203C":null},"has_protein_features":false,"name":"MSS51","ortholog_annotations":[{"gene_uniquename":"YLR203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02979","reference_uniquename":"PMID:29761456"}],"product":"Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; localizes to vacuole membrane in response to H2O2; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004193","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR203C"}


id: YLR204W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00077":null,"YLR204W":null},"has_protein_features":false,"name":"QRI5","ortholog_annotations":[{"gene_uniquename":"YLR204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00077","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein; required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004194","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR204W"}


id: YLR205C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HMX1","product":"ER localized heme oxygenase; involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants","secondary_identifier":"SGD:S000004195","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR205C"}


id: YLR206W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04644":null,"YLR206W":null},"has_protein_features":false,"name":"ENT2","ortholog_annotations":[{"gene_uniquename":"YLR206W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04644","reference_uniquename":"PMID:29761456"}],"product":"Epsin-like protein required for endocytosis and actin patch assembly; K48-, K63-specific Ub chain binding protein that functions as an endocytic adaptor; contains clathrin-binding motif at C-terminus; functionally redundant with Ent1p; ENT2 has a paralog, ENT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004196","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR206W"}


id: YLR207W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01709":null,"SJAG_04345":null,"YLR207W":null},"has_protein_features":false,"name":"HRD3","ortholog_annotations":[{"gene_uniquename":"YLR207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01709","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04345","reference_uniquename":"PMID:29761456"}],"product":"ER membrane protein that plays a central role in ERAD; forms HRD complex with Hrd1p and ER-associated protein degradation (ERAD) determinants that engages in lumen to cytosol communication and coordination of ERAD events","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004197","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR207W"}


id: YLR208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03907":null,"YLR208W":null},"has_protein_features":false,"name":"SEC13","ortholog_annotations":[{"gene_uniquename":"YLR208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03907","reference_uniquename":"PMID:29761456"}],"product":"Structural component of 3 complexes; subunit of the Nup84p nuclear pore subcomplex that contributes to nucleocytoplasmic transport and NPC biogenesis; subunit of the COPII vesicle coat required for ER-to-Golgi transport; subunit of SEACAT, a subcomplex of the coatomer-related, vacuolar-associated SEA complex, that inhibits the TORC1 inhibitory role of SEACIT (Iml1p-Npr2p-Npr3p), a GAP for Gtr1p, thereby resulting in activation of TORC1 signaling; human SEC13 homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004198","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR208W"}


id: YLR209C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01359":null,"YLR209C":null},"has_protein_features":false,"name":"PNP1","ortholog_annotations":[{"gene_uniquename":"YLR209C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01359","reference_uniquename":"PMID:29761456"}],"product":"Purine nucleoside phosphorylase; specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004199","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR209C"}


id: YLR210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03525":null,"SJAG_03699":null,"YLR210W":null},"has_protein_features":false,"name":"CLB4","ortholog_annotations":[{"gene_uniquename":"YLR210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03525","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03699","reference_uniquename":"PMID:29761456"}],"product":"B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; CLB4 has a paralog, CLB3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004200","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR210W"}


id: YLR211C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04860":null,"YLR211C":null},"has_protein_features":false,"name":"ATG38","ortholog_annotations":[{"gene_uniquename":"YLR211C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04860","reference_uniquename":"PMID:29761456"}],"product":"Homodimeric subunit of autophagy-specific PtdIns-3-kinase complex I; required for the integrity of the active PtdIns-3-kinase complex I by maintaining an association between Vps15p-Vps34p and Atg14p-Vps30p subcomplexes; localizes to the pre-autophagosomal structure (PAS) in an Atg14p-dependent manner; ATG38 is non-essential but is required for macroautophagy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004201","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR211C"}


id: YLR212C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01215":null,"YLR212C":null},"has_protein_features":false,"name":"TUB4","ortholog_annotations":[{"gene_uniquename":"YLR212C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01215","reference_uniquename":"PMID:29761456"}],"product":"Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress; null mutation is complemented by human TUBG1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004202","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR212C"}


id: YLR213C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04327":null,"YLR213C":null},"has_protein_features":false,"name":"CRR1","ortholog_annotations":[{"gene_uniquename":"YLR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04327","reference_uniquename":"PMID:29761456"}],"product":"Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004203","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR213C"}


id: YLR214W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04743":null,"YLR214W":null},"has_protein_features":false,"name":"FRE1","ortholog_annotations":[{"gene_uniquename":"YLR214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004204","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR214W"}


id: YLR215C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00353":null,"YLR215C":null},"has_protein_features":false,"name":"CDC123","ortholog_annotations":[{"gene_uniquename":"YLR215C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00353","reference_uniquename":"PMID:29761456"}],"product":"Assembly factor for the eIF2 translation initiation factor complex; regulates translational initiation; conserved residues of this ATP-Grasp protein that bind to ATP-Mg2+ in the pombe ortholog are required for complex assembly in budding yeast; interaction with eIF2 subunit Gcd11p facilitates complex assembly and activity; required for the START transition and timely progression through G2; regulated by nutrient availability; human ortholog complements the yeast mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004205","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR215C"}


id: YLR216C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04352":null,"YLR216C":null},"has_protein_features":false,"name":"CPR6","ortholog_annotations":[{"gene_uniquename":"YLR216C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04352","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; plays a role in determining prion variants; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004206","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR216C"}


id: YLR217W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6","secondary_identifier":"SGD:S000004207","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR217W"}


id: YLR218C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04116":null,"YLR218C":null},"has_protein_features":false,"name":"COA4","ortholog_annotations":[{"gene_uniquename":"YLR218C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04116","reference_uniquename":"PMID:29761456"}],"product":"Twin Cx(9)C protein involved in cytochrome c oxidase organization; organization includes assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors; mutation can be complemented by human COA4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004208","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR218C"}


id: YLR219W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MSC3","product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004209","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR219W"}


id: YLR220W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04867":null,"YLR220W":null},"has_protein_features":false,"name":"CCC1","ortholog_annotations":[{"gene_uniquename":"YLR220W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04867","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to vacuole decreases upon DNA replication stress; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004210","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR220W"}


id: YLR221C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04992":null,"YLR221C":null},"has_protein_features":false,"name":"RSA3","ortholog_annotations":[{"gene_uniquename":"YLR221C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04992","reference_uniquename":"PMID:29761456"}],"product":"Protein with a likely role in ribosomal maturation; required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004211","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR221C"}


id: YLR222C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04224":null,"YLR222C":null},"has_protein_features":false,"name":"UTP13","ortholog_annotations":[{"gene_uniquename":"YLR222C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04224","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004212","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR222C"}


id: YLR222C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene IFH1","secondary_identifier":"SGD:S000028568","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR222C-A"}


id: YLR223C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02671":null,"YLR223C":null},"has_protein_features":false,"name":"IFH1","ortholog_annotations":[{"gene_uniquename":"YLR223C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02671","reference_uniquename":"PMID:29761456"}],"product":"Coactivator, regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing; regulated by acetylation and phosphorylation at different growth states via TORC1 signaling; IFH1 has a paralog, CRF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004213","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR223C"}


id: YLR224W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UCC1","product":"F-box protein and component of SCF ubiquitin ligase complexes; involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; SCF-Ucc1 regulates level of Cit2 citrate synthase protein to maintain citrate homeostasis, acts as metabolic switch for glyoxylate cycle; UCC1 transcription is downregulated in cells grown on C2-compounds","secondary_identifier":"SGD:S000004214","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR224W"}


id: YLR225C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YLR225C has a paralog, YDR222W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004215","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR225C"}


id: YLR226W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01213":null,"YLR226W":null},"has_protein_features":false,"name":"BUR2","ortholog_annotations":[{"gene_uniquename":"YLR226W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01213","reference_uniquename":"PMID:29761456"}],"product":"Cyclin for the Sgv1p (Bur1p) protein kinase; subunit of the CDK-cyclin BUR kinase complex with Sgv1p (Bur1p); regulates Set2p-dependent H3K36 trimethylation; regulates transcriptional elongation through the phosphorylation of the carboxy-terminal domain (CTD) of Rpo21p; involved in the recruitment of Spt6p to the CTD at the onset of transcription; regulates telomere elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004216","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR226W"}


id: YLR227C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ADY4","product":"Structural component of the meiotic outer plaque; outer plaque is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane","secondary_identifier":"SGD:S000004217","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR227C"}


id: YLR228C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM22","product":"Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes upon sterol depletion, after relocating from intracellular membranes to perinuclear foci; redundant activator of filamentation with UPC2, up-regulating the expression of genes involved in filamentous growth; contains Zn[2]-Cys[6] binuclear cluster; ECM22 has a paralog, UPC2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004218","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR228C"}


id: YLR229C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04509":null,"YLR229C":null},"has_protein_features":false,"name":"CDC42","ortholog_annotations":[{"gene_uniquename":"YLR229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04509","reference_uniquename":"PMID:29761456"}],"product":"Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; acts with ESCRT proteins at sites of nuclear envelope and ER fission; mutants have defects in the organization of actin and septins; human homolog CDC42 can complement yeast cdc42 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004219","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR229C"}


id: YLR230W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42/YLR229C gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity","secondary_identifier":"SGD:S000004220","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR230W"}


id: YLR231C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BNA5","product":"Kynureninase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p","secondary_identifier":"SGD:S000004221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR231C"}


id: YLR232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5","secondary_identifier":"SGD:S000004222","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR232W"}


id: YLR233C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00939":null,"YLR233C":null},"has_protein_features":false,"name":"EST1","ortholog_annotations":[{"gene_uniquename":"YLR233C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00939","reference_uniquename":"PMID:29761456"}],"product":"TLC1 RNA-associated factor involved in telomere length regulation; recruitment subunit of telomerase; has G-quadruplex promoting activity required for telomere elongation; role in activating telomere-bound Est2p-TLC1-RNA; EST1 has a paralog, EBS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR233C"}


id: YLR234W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04816":null,"YLR234W":null},"has_protein_features":false,"name":"TOP3","ortholog_annotations":[{"gene_uniquename":"YLR234W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04816","reference_uniquename":"PMID:29761456"}],"product":"DNA Topoisomerase III; conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially; DNA catenation/decatenation activity is stimulated by RPA and Sgs1p-Top3p-Rmi1p; involved in telomere stability and regulation of mitotic recombination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR234W"}


id: YLR235C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORFs TOP3/YLR234W and YLR236C","secondary_identifier":"SGD:S000004225","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR235C"}


id: YLR236C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; overlaps ORF YLR235C","secondary_identifier":"SGD:S000004226","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR236C"}


id: YLR237W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"THI7","product":"Plasma membrane transporter responsible for the uptake of thiamine; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia","secondary_identifier":"SGD:S000004227","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR237W"}


id: YLR238W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04455":null,"YLR238W":null},"has_protein_features":false,"name":"FAR10","ortholog_annotations":[{"gene_uniquename":"YLR238W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04455","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate; FAR10 has a paralog, VPS64, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004228","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR238W"}


id: YLR239C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01271":null,"YLR239C":null},"has_protein_features":false,"name":"LIP2","ortholog_annotations":[{"gene_uniquename":"YLR239C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01271","reference_uniquename":"PMID:29761456"}],"product":"Lipoyl ligase; involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004229","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR239C"}


id: YLR240W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00114":null,"YLR240W":null},"has_protein_features":false,"name":"VPS34","ortholog_annotations":[{"gene_uniquename":"YLR240W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00114","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR240W"}


id: YLR241W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03895":null,"YLR241W":null},"has_protein_features":false,"name":"CSC1","ortholog_annotations":[{"gene_uniquename":"YLR241W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03895","reference_uniquename":"PMID:29761456"}],"product":"Calcium permeable gated cation channel; functions as an osmosensitive, calcium-permeable cation channel when expressed in a heterologous system; may be involved in detoxification; similar to Arabidopsis CSC1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR241W"}


id: YLR242C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00261":null,"YLR242C":null},"has_protein_features":false,"name":"ARV1","ortholog_annotations":[{"gene_uniquename":"YLR242C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00261","reference_uniquename":"PMID:29761456"}],"product":"Cortical ER protein; implicated in the membrane insertion of tail-anchored C-terminal single transmembrane domain proteins; may function in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution; human ARV1, required for normal cholesterol and bile acid homeostasis, can complement yeast arv1 null mutant; human variant causing early onset epileptic encephalopathy is unable to rescue the yeast null","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR242C"}


id: YLR243W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01655":null,"YLR243W":null},"has_protein_features":false,"name":"GPN3","ortholog_annotations":[{"gene_uniquename":"YLR243W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01655","reference_uniquename":"PMID:29761456"}],"product":"Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; may have a role in sister chromatid cohesion; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR243W"}


id: YLR244C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02033":null,"YLR244C":null},"has_protein_features":false,"name":"MAP1","ortholog_annotations":[{"gene_uniquename":"YLR244C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02033","reference_uniquename":"PMID:29761456"}],"product":"Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p; apo-Map1p is activated by the GTP-dependent zinc transferase Zng1p, especially during zinc starvation; interacts with Zng1p via an N-terminal Zn finger domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR244C"}


id: YLR245C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01673":null,"YLR245C":null},"has_protein_features":false,"name":"CDD1","ortholog_annotations":[{"gene_uniquename":"YLR245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01673","reference_uniquename":"PMID:29761456"}],"product":"Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR245C"}


id: YLR246W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04451":null,"YLR246W":null},"has_protein_features":false,"name":"ERF2","ortholog_annotations":[{"gene_uniquename":"YLR246W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04451","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a palmitoyltransferase; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole; palmitoyltransferase is composed of Erf2p and Shr5p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR246W"}


id: YLR247C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00111":null,"YLR247C":null},"has_protein_features":false,"name":"IRC20","ortholog_annotations":[{"gene_uniquename":"YLR247C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00111","reference_uniquename":"PMID:29761456"}],"product":"E3 ubiquitin ligase and putative helicase; involved in synthesis-dependent strand annealing-mediated homologous recombination; ensures precise end-joining along with Srs2p in the Yku70p/Yku80p/Lig4p-dependent NHEJ pathway; controls 2-micron plasmid copy number by regulating the levels of the Flp1p recombinase; localizes to both the mitochondrion and the nucleus; contains a Snf2/Swi2 family ATPase/helicase and a RING finger domain; null mutant displays increased levels of spontaneous Rad52p foci","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR247C"}


id: YLR248W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01084":null,"SJAG_01855":null,"YLR248W":null},"has_protein_features":false,"name":"RCK2","ortholog_annotations":[{"gene_uniquename":"YLR248W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01084","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR248W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01855","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR248W"}


id: YLR249W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02738":null,"YLR249W":null},"has_protein_features":false,"name":"YEF3","ortholog_annotations":[{"gene_uniquename":"YLR249W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02738","reference_uniquename":"PMID:29761456"}],"product":"Translation elongation factor 3; contains two ABC cassettes; binds and hydrolyzes ATP; interacts with mRNA independently of translation; involved in frameshifting at stalled ribosomes; YEF3 has a paralog, HEF3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR249W"}


id: YLR250W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00751":null,"YLR250W":null},"has_protein_features":false,"name":"SSP120","ortholog_annotations":[{"gene_uniquename":"YLR250W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00751","reference_uniquename":"PMID:29761456"}],"product":"Protein packaged into COPII vesicles for ER to Golgi trafficking; forms a complex with Emp47p that may function in trafficking plasma membrane glycoproteins through early secretory pathway; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR250W"}


id: YLR251W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00631":null,"YLR251W":null},"has_protein_features":false,"name":"SYM1","ortholog_annotations":[{"gene_uniquename":"YLR251W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00631","reference_uniquename":"PMID:29761456"}],"product":"Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; lysine auxotroph proposed to function in pyrimidine metabolism; homologous to mammalian peroxisomal membrane protein Mpv17; human homolog MPV17 is implicated in hepatocerebral mtDNA depletion syndromes (MDDS), and complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR251W"}


id: YLR252W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism","secondary_identifier":"SGD:S000004242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR252W"}


id: YLR253W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02064":null,"YLR253W":null},"has_protein_features":false,"name":"CQD2","ortholog_annotations":[{"gene_uniquename":"YLR253W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02064","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein involved in lipid homeostasis; involved in mobilization of CoQ from its site of synthesis on the inner mitochondrial membrane to other sites of action; associates with mitochondrial ribosome; involved in mitochondrial morphology; non-essential gene which interacts genetically with MDM10, and other members of ERMES complex; transcription is periodic during metabolic cycle; homologous to human aarF domain containing kinase, ADCK1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR253W"}


id: YLR254C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NDL1","product":"Homolog of nuclear distribution factor NudE; NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends; localizes to cytosol, nucleus and peroxisomes","secondary_identifier":"SGD:S000004244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR254C"}


id: YLR255C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000004245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR255C"}


id: YLR256W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HAP1","product":"Zinc finger transcription factor; involved in the complex regulation of gene expression in response to levels of heme and oxygen; localizes to the mitochondrion as well as to the nucleus; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus","secondary_identifier":"SGD:S000004246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR256W"}


id: YLR257W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR257W"}


id: YLR258W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GSY2","product":"Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress","secondary_identifier":"SGD:S000004248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR258W"}


id: YLR259C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00564":null,"YLR259C":null},"has_protein_features":false,"name":"HSP60","ortholog_annotations":[{"gene_uniquename":"YLR259C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00564","reference_uniquename":"PMID:29761456"}],"product":"Tetradecameric mitochondrial chaperonin; required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR259C"}


id: YLR260W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02429":null,"YLR260W":null},"has_protein_features":false,"name":"LCB5","ortholog_annotations":[{"gene_uniquename":"YLR260W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02429","reference_uniquename":"PMID:29761456"}],"product":"Minor sphingoid long-chain base kinase; possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules; LCB5 has a paralog, LCB4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR260W"}


id: YLR261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VPS63","product":"Putative protein of unknown function; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect; decreased levels of protein in enolase deficient mutant","secondary_identifier":"SGD:S000004251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR261C"}


id: YLR262C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05030":null,"YLR262C":null},"has_protein_features":false,"name":"YPT6","ortholog_annotations":[{"gene_uniquename":"YLR262C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05030","reference_uniquename":"PMID:29761456"}],"product":"Rab family GTPase; required for endosome-to-Golgi, intra-Golgi retrograde, and retrograde Golgi-to-ER transport; temporarily at the Golgi, dissociating into the cytosol on arrival of the late Golgi GTPase Ypt32p; Golgi-localized form is GTP bound, while cytosolic form is GDP-bound; required for delivery of Atg9p to the phagophore assembly site during autophagy under heat stress, with Ypt6p for starvation induced autophagy and for the CVT pathway; homolog of mammalian Rab6","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR262C"}


id: YLR262C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TMA7","product":"Protein of unknown function that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000007246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR262C-A"}


id: YLR263W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04748":null,"YLR263W":null},"has_protein_features":false,"name":"RED1","ortholog_annotations":[{"gene_uniquename":"YLR263W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04748","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the synaptonemal complex axial elements; involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; promotes interhomolog recombination by phosphorylating Hop1p; also interacts with Mec3p and Ddc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR263W"}


id: YLR264C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR264C-A"}


id: YLR264W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02749":null,"SJAG_04746":null,"YLR264W":null},"has_protein_features":false,"name":"RPS28B","ortholog_annotations":[{"gene_uniquename":"YLR264W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02749","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR264W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04746","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; has an extraribosomal function in autoregulation, in which Rps28Bp binds to a decapping complex via Edc3p, which then binds to RPS28B mRNA leading to its decapping and degradation; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR264W"}


id: YLR265C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04199":null,"YLR265C":null},"has_protein_features":false,"name":"NEJ1","ortholog_annotations":[{"gene_uniquename":"YLR265C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04199","reference_uniquename":"PMID:29761456"}],"product":"DNA end-binding protein required for nonhomologous end joining (NHEJ); subunit of the DNA ligase IV complex involved in initial end binding, intermolecular ligation, and DNA ligase reactivation after completion of repair; phosphorylation by Tpk1p is required for DNA damage induced NHEJ and for nuclear targeting of Nej1p and Lif1p; human homolog NHEJ1 is phosphorylated by human Tpk1p homolog PRKACB, regulating NHEJ; transcriptionally repressed by MAT heterozygosity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR265C"}


id: YLR266C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PDR8","product":"Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR266C"}


id: YLR267W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BOP2","product":"Protein of unknown function","secondary_identifier":"SGD:S000004257","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR267W"}


id: YLR268W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00557":null,"YLR268W":null},"has_protein_features":false,"name":"SEC22","ortholog_annotations":[{"gene_uniquename":"YLR268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00557","reference_uniquename":"PMID:29761456"}],"product":"R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004258","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR268W"}


id: YLR269C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004259","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR269C"}


id: YLR270W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01625":null,"YLR270W":null},"has_protein_features":false,"name":"DCS1","ortholog_annotations":[{"gene_uniquename":"YLR270W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01625","reference_uniquename":"PMID:29761456"}],"product":"Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; acts as inhibitor of neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress; DCS1 has a paralog, DCS2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004260","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR270W"}


id: YLR271W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01380":null,"YLR271W":null},"has_protein_features":false,"name":"CMG1","ortholog_annotations":[{"gene_uniquename":"YLR271W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01380","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004261","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR271W"}


id: YLR272C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03161":null,"YLR272C":null},"has_protein_features":false,"name":"YCS4","ortholog_annotations":[{"gene_uniquename":"YLR272C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03161","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004262","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR272C"}


id: YLR273C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PIG1","product":"Putative targeting subunit for type-1 protein phosphatase Glc7p; tethers Glc7p to Gsy2p glycogen synthase; PIG1 has a paralog, GAC1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004263","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR273C"}


id: YLR274W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01354":null,"YLR274W":null},"has_protein_features":false,"name":"MCM5","ortholog_annotations":[{"gene_uniquename":"YLR274W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01354","reference_uniquename":"PMID:29761456"}],"product":"Component of the Mcm2-7 hexameric helicase complex; MCM complex is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004264","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR274W"}


id: YLR275W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02304":null,"YLR275W":null},"has_protein_features":false,"name":"SMD2","ortholog_annotations":[{"gene_uniquename":"YLR275W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02304","reference_uniquename":"PMID:29761456"}],"product":"Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004265","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR275W"}


id: YLR276C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04650":null,"YLR276C":null},"has_protein_features":false,"name":"DBP9","ortholog_annotations":[{"gene_uniquename":"YLR276C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04650","reference_uniquename":"PMID:29761456"}],"product":"DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004266","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR276C"}


id: YLR277C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04587":null,"YLR277C":null},"has_protein_features":false,"name":"YSH1","ortholog_annotations":[{"gene_uniquename":"YLR277C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04587","reference_uniquename":"PMID:29761456"}],"product":"Endoribonuclease; subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs; protein abundance increases in response to DNA replication stress; YSH1 has a paralog, SYC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004267","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR277C"}


id: YLR278C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; associates with rDNA chromatin in vivo; YLR278C is not an essential gene","secondary_identifier":"SGD:S000004268","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR278C"}


id: YLR279W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004269","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR279W"}


id: YLR280C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004270","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR280C"}


id: YLR281C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00308":null,"YLR281C":null},"has_protein_features":false,"name":"RSO55","ortholog_annotations":[{"gene_uniquename":"YLR281C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00308","reference_uniquename":"PMID:29761456"}],"product":"Stalled-ribosome rescue factor srRF2; mitochondrial protein required for respiratory growth in presence of bacteriostatic ribosome-binding antibiotics; not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004271","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR281C"}


id: YLR282C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition","secondary_identifier":"SGD:S000004272","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR282C"}


id: YLR283W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03505":null,"YLR283W":null},"has_protein_features":false,"name":"PUT7","ortholog_annotations":[{"gene_uniquename":"YLR283W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03505","reference_uniquename":"PMID:29761456"}],"product":"Regulator of mitochondrial proline metabolism; tethered with Fmp32p to inner mitochondrial membrane in large hetero-oligomeric complex, abundance of which is regulated by proline; involved in mitochondrial proline homeostasis and cellular redox balance; null exhibits pronounced defect in proline utilization, and can be functionally complemented by expression of human homolog MCUR1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004273","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR283W"}


id: YLR284C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECI1","product":"Peroxisomal delta3,delta2-enoyl-CoA isomerase; hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced; ECI1 has a paralog, DCI1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004274","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR284C"}


id: YLR285C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028569","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR285C-A"}


id: YLR285W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01425":null,"YLR285W":null},"has_protein_features":false,"name":"NNT1","ortholog_annotations":[{"gene_uniquename":"YLR285W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01425","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine-dependent methyltransferase; novel N-terminal protein methyltransferase that trimethylates the N-terminal glycine residue (G2) and also dimethylates lysine (K3) on elongation factor eEF1A (Tef1p/Tef2p); has a role in rDNA silencing and in lifespan determination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004275","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR285W"}


id: YLR286C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00620":null,"YLR286C":null},"has_protein_features":false,"name":"CTS1","ortholog_annotations":[{"gene_uniquename":"YLR286C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00620","reference_uniquename":"PMID:29761456"}],"product":"Endochitinase; required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004276","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR286C"}


id: YLR286W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene CTS1","secondary_identifier":"SGD:S000028679","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR286W-A"}


id: YLR287C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04390":null,"YLR287C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR287C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04390","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004277","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR287C"}


id: YLR287C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01287":null,"SJAG_02224":null,"YLR287C-A":null},"has_protein_features":false,"name":"RPS30A","ortholog_annotations":[{"gene_uniquename":"YLR287C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01287","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR287C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02224","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004278","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR287C-A"}


id: YLR288C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03026":null,"YLR288C":null},"has_protein_features":false,"name":"MEC3","ortholog_annotations":[{"gene_uniquename":"YLR288C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03026","reference_uniquename":"PMID:29761456"}],"product":"DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004279","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR288C"}


id: YLR289W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04351":null,"YLR289W":null},"has_protein_features":false,"name":"GUF1","ortholog_annotations":[{"gene_uniquename":"YLR289W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04351","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial matrix GTPase; associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004280","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR289W"}


id: YLR290C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01820":null,"YLR290C":null},"has_protein_features":false,"name":"COQ11","ortholog_annotations":[{"gene_uniquename":"YLR290C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01820","reference_uniquename":"PMID:29761456"}],"product":"Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes; required for synthesis of wild-type levels of Coenzyme Q (ubiquinone); member of the short-chain dehydrogenase/reductase (SDR) superfamily; orthologous gene in some other fungi is fused to the COQ10 ortholog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004281","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR290C"}


id: YLR291C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01576":null,"YLR291C":null},"has_protein_features":false,"name":"GCD7","ortholog_annotations":[{"gene_uniquename":"YLR291C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01576","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as negative regulator of GCN4 expression; mutations in human ortholog EIF2B2 cause fatal brain disease childhood ataxia with central nervous system hypomyelination (CACH); human ortholog can complement yeast mutant, allows growth down-regulation of yeast gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004282","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR291C"}


id: YLR292C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03955":null,"YLR292C":null},"has_protein_features":false,"name":"SEC72","ortholog_annotations":[{"gene_uniquename":"YLR292C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03955","reference_uniquename":"PMID:29761456"}],"product":"Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and translocation into the ER; other members are Sec63p, Sec62p, and Sec66p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004283","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR292C"}


id: YLR293C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01449":null,"YLR293C":null},"has_protein_features":false,"name":"GSP1","ortholog_annotations":[{"gene_uniquename":"YLR293C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01449","reference_uniquename":"PMID:29761456"}],"product":"Ran GTPase; GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; GSP1 has a paralog, GSP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004284","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR293C"}


id: YLR294C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14","secondary_identifier":"SGD:S000004285","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR294C"}


id: YLR295C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00542":null,"YLR295C":null},"has_protein_features":false,"name":"ATP14","ortholog_annotations":[{"gene_uniquename":"YLR295C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00542","reference_uniquename":"PMID:29761456"}],"product":"Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004286","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR295C"}


id: YLR296W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000004287","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR296W"}


id: YLR297W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004288","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR297W"}


id: YLR298C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03983":null,"YLR298C":null},"has_protein_features":false,"name":"YHC1","ortholog_annotations":[{"gene_uniquename":"YLR298C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03983","reference_uniquename":"PMID:29761456"}],"product":"Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004289","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR298C"}


id: YLR299C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene ECM38","secondary_identifier":"SGD:S000028680","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR299C-A"}


id: YLR299W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01612":null,"SJAG_03316":null,"YLR299W":null},"has_protein_features":false,"name":"ECM38","ortholog_annotations":[{"gene_uniquename":"YLR299W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01612","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR299W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03316","reference_uniquename":"PMID:29761456"}],"product":"Gamma-glutamyltranspeptidase; major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004290","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR299W"}


id: YLR300W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01171":null,"SJAG_01888":null,"SJAG_05001":null,"YLR300W":null},"has_protein_features":false,"name":"EXG1","ortholog_annotations":[{"gene_uniquename":"YLR300W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01171","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR300W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01888","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR300W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05001","reference_uniquename":"PMID:29761456"}],"product":"Major exo-1,3-beta-glucanase of the cell wall; involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes; EXG1 has a paralog, SPR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004291","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR300W"}


id: YLR301W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HRI1","product":"Protein of unknown function that interacts with Sec72p and Hrr25p","secondary_identifier":"SGD:S000004292","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR301W"}


id: YLR302C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000004293","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR302C"}


id: YLR303W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02972":null,"YLR303W":null},"has_protein_features":false,"name":"MET17","ortholog_annotations":[{"gene_uniquename":"YLR303W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02972","reference_uniquename":"PMID:29761456"}],"product":"O-acetyl homoserine-O-acetyl serine sulfhydrylase; involved in methionine and cysteine biosynthesis; long considered essential for inorganic sulfur assimilation, but inefficient homocysteine synthase Hsu1p enables met17 null cells to assimilate enough inorganic sulfur for survival and proliferation; growth failure of met17 null can be explained by toxic accumulation of H2S gas due to a metabolic bottleneck","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004294","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR303W"}


id: YLR304C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03588":null,"YLR304C":null},"has_protein_features":false,"name":"ACO1","ortholog_annotations":[{"gene_uniquename":"YLR304C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03588","reference_uniquename":"PMID:29761456"}],"product":"Aconitase; required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy; mutation in human homolog ACO2 is associated with dominant optic nerve atrophy; human homolog ACO2 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004295","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR304C"}


id: YLR305C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04537":null,"YLR305C":null},"has_protein_features":false,"name":"STT4","ortholog_annotations":[{"gene_uniquename":"YLR305C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04537","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol-4-kinase; functions in Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization; required for autophagosome-vacuole fusion during autophagy and for lipophagy in stationary phase cells and during nitrogen starvation; localizes to plasma membrane and mitochondria in HTP studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004296","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR305C"}


id: YLR306W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01018":null,"YLR306W":null},"has_protein_features":false,"name":"UBC12","ortholog_annotations":[{"gene_uniquename":"YLR306W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01018","reference_uniquename":"PMID:29761456"}],"product":"Enzyme that mediates the conjugation of Rub1p; a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004297","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR306W"}


id: YLR307C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DPA10","product":"Putative mitochondrial protein of unknown function","secondary_identifier":"SGD:S000028525","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR307C-A"}


id: YLR307W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03013":null,"YLR307W":null},"has_protein_features":false,"name":"CDA1","ortholog_annotations":[{"gene_uniquename":"YLR307W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03013","reference_uniquename":"PMID:29761456"}],"product":"Chitin deacetylase; together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004298","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR307W"}


id: YLR308W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03013":null,"YLR308W":null},"has_protein_features":false,"name":"CDA2","ortholog_annotations":[{"gene_uniquename":"YLR308W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03013","reference_uniquename":"PMID:29761456"}],"product":"Chitin deacetylase; together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004299","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR308W"}


id: YLR309C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00144":null,"SJAG_03838":null,"YLR309C":null},"has_protein_features":false,"name":"IMH1","ortholog_annotations":[{"gene_uniquename":"YLR309C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00144","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR309C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03838","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in vesicular transport; mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004300","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR309C"}


id: YLR310C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02486":null,"SJAG_02819":null,"YLR310C":null},"has_protein_features":false,"name":"CDC25","ortholog_annotations":[{"gene_uniquename":"YLR310C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02486","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR310C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02819","reference_uniquename":"PMID:29761456"}],"product":"Membrane bound guanine nucleotide exchange factor; also known as a GEF or GDP-release factor; indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1; thermosensitivity of the cdc25-5 mutant is functionally complemented by human RASGRF1 or by a fragment of human SOS1 comprising the CDC25-related catalytic domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004301","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR310C"}


id: YLR311C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004302","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR311C"}


id: YLR312C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG39","product":"Transmembrane receptor with a role in nucleophagy; involved in selective autophagy of the endoplasmic reticulum and nucleus in response to nitrogen starvation or rapamycin treatment; role in nuclear envelope deformation to generate nucleus-derived double-membrane vesicles (NDVs), interacting with Atg8p to target these NDVs to forming autophagosomal membranes; anchored in the outer nuclear membrane, associating with the inner nuclear membrane via amphipathic helices","secondary_identifier":"SGD:S000004303","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR312C"}


id: YLR312C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YLR312C-B was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, SPH1/YLR313C","secondary_identifier":"SGD:S000028570","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR312C-B"}


id: YLR312W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01463":null,"YLR312W-A":null},"has_protein_features":false,"name":"MRPL15","ortholog_annotations":[{"gene_uniquename":"YLR312W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01463","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004304","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR312W-A"}


id: YLR313C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03625":null,"YLR313C":null},"has_protein_features":false,"name":"SPH1","ortholog_annotations":[{"gene_uniquename":"YLR313C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03625","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in shmoo formation and bipolar bud site selection; localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p; SPH1 has a paralog, SPA2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004305","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR313C"}


id: YLR314C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01277":null,"SJAG_03688":null,"YLR314C":null},"has_protein_features":false,"name":"CDC3","ortholog_annotations":[{"gene_uniquename":"YLR314C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01277","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR314C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03688","reference_uniquename":"PMID:26896847"}],"product":"Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004306","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR314C"}


id: YLR315W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00350":null,"YLR315W":null},"has_protein_features":false,"name":"NKP2","ortholog_annotations":[{"gene_uniquename":"YLR315W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00350","reference_uniquename":"PMID:29761456"}],"product":"Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004307","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR315W"}


id: YLR316C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00352":null,"YLR316C":null},"has_protein_features":false,"name":"TAD3","ortholog_annotations":[{"gene_uniquename":"YLR316C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00352","reference_uniquename":"PMID:29761456"}],"product":"Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs; localizes to cytosol, nucleus and peroxisomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004308","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR316C"}


id: YLR317W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C","secondary_identifier":"SGD:S000004309","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR317W"}


id: YLR318W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05979":null,"YLR318W":null},"has_protein_features":false,"name":"EST2","ortholog_annotations":[{"gene_uniquename":"YLR318W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05979","reference_uniquename":"PMID:29761456"}],"product":"Reverse transcriptase subunit of the telomerase holoenzyme; essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004310","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR318W"}


id: YLR319C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04624":null,"YLR319C":null},"has_protein_features":false,"name":"BUD6","ortholog_annotations":[{"gene_uniquename":"YLR319C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04624","reference_uniquename":"PMID:29761456"}],"product":"Actin- and formin-interacting protein; nucleation-promoting factor (NPF) for Bni1p and Bnr1p during actin cable assembly and organization; enhances Bnr1p-mediated actin nucleation, alleviating Hof1p inhibition through competitive binding; interacts with Bni1p via a C-terminal triple helical coiled-coil domain; role in polarized cell growth; isolated as a bipolar budding mutant; localizes to the presumptive bud site, small bud tips, the bud neck and secretory vesicles; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004311","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR319C"}


id: YLR320W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04971":null,"YLR320W":null},"has_protein_features":false,"name":"MMS22","ortholog_annotations":[{"gene_uniquename":"YLR320W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04971","reference_uniquename":"PMID:29761456"}],"product":"Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of replication fork, such as fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; Rtt101p-Mms22p ligase associates with replisome complex during S phase via Ctf4p; required for accurate meiotic chromosome segregation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004312","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR320W"}


id: YLR321C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04213":null,"YLR321C":null},"has_protein_features":false,"name":"SFH1","ortholog_annotations":[{"gene_uniquename":"YLR321C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04213","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog; hSNF5 tumor suppressor ortholog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004313","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR321C"}


id: YLR322W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VPS65","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth","secondary_identifier":"SGD:S000004314","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR322W"}


id: YLR323C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03112":null,"YLR323C":null},"has_protein_features":false,"name":"CWC24","ortholog_annotations":[{"gene_uniquename":"YLR323C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03112","reference_uniquename":"PMID:29761456"}],"product":"General splicing factor; required for stable U2 snRNP binding to primary transcripts; essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; similar to S. pombe Cwf24p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004315","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR323C"}


id: YLR324W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PEX30","product":"ER-resident protein involved in peroxisomal biogenesis; ER-localized protein that associates with peroxisomes; interacts with Pex29p and reticulons Rtn1p and Yop1p to regulate peroxisome biogenesis from the ER; role in peroxisomal-destined vesicular flow from the ER; partially redundant with Pex31p; may function at a step downstream of steps mediated by Pex28p and Pex29p; PEX30 has a paralog, PEX31, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004316","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR324W"}


id: YLR325C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02081":null,"SJAG_04534":null,"YLR325C":null},"has_protein_features":false,"name":"RPL38","ortholog_annotations":[{"gene_uniquename":"YLR325C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02081","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR325C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04534","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004317","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR325C"}


id: YLR326W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery; predicted to be palmitoylated","secondary_identifier":"SGD:S000004318","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR326W"}


id: YLR327C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TMA10","product":"Protein of unknown function that associates with ribosomes; protein abundance increases in response to DNA replication stress; TMA10 has a paralog, STF2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004319","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR327C"}


id: YLR328W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02889":null,"YLR328W":null},"has_protein_features":false,"name":"NMA1","ortholog_annotations":[{"gene_uniquename":"YLR328W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02889","reference_uniquename":"PMID:29761456"}],"product":"Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; homolog of human NMNAT; NMA1 has a paralog, NMA2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004320","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR328W"}


id: YLR329W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01156":null,"YLR329W":null},"has_protein_features":false,"name":"REC102","ortholog_annotations":[{"gene_uniquename":"YLR329W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01156","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004321","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR329W"}


id: YLR330W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02240":null,"YLR330W":null},"has_protein_features":false,"name":"CHS5","ortholog_annotations":[{"gene_uniquename":"YLR330W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02240","reference_uniquename":"PMID:29761456"}],"product":"Component of the exomer complex; the exomer which also contains Csh6p, Bch1p, Bch2p, and Bud7, is involved in the export of select proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane; interacts selectively with the activated, GTP-bound form of Arf1p; Chs5p is the only protein with a BRCT domain that is not localized to the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004322","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR330W"}


id: YLR331C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"JIP3","product":"Putative protein of unknown function; conserved among S. cerevisiae strains; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2","secondary_identifier":"SGD:S000004323","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR331C"}


id: YLR332W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03969":null,"YLR332W":null},"has_protein_features":false,"name":"MID2","ortholog_annotations":[{"gene_uniquename":"YLR332W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03969","reference_uniquename":"PMID:29761456"}],"product":"O-glycosylated plasma membrane protein; acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p; MID2 has a paralog, MTL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004324","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR332W"}


id: YLR333C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04672":null,"YLR333C":null},"has_protein_features":false,"name":"RPS25B","ortholog_annotations":[{"gene_uniquename":"YLR333C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04672","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25B has a paralog, RPS25A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004325","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR333C"}


id: YLR334C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here","secondary_identifier":"SGD:S000004326","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR334C"}


id: YLR335W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04284":null,"YLR335W":null},"has_protein_features":false,"name":"NUP2","ortholog_annotations":[{"gene_uniquename":"YLR335W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04284","reference_uniquename":"PMID:29761456"}],"product":"Nucleoporin involved in nucleocytoplasmic transport; binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization; involved with Nup60p in nuclear basket remodeling during meiosis; Cdc5p-mediated phosphorylation of Nup60p leads to detachment and reattachment of nuclear basket","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004327","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR335W"}


id: YLR336C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03583":null,"YLR336C":null},"has_protein_features":false,"name":"SGD1","ortholog_annotations":[{"gene_uniquename":"YLR336C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03583","reference_uniquename":"PMID:29761456"}],"product":"Essential nuclear protein; required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004328","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR336C"}


id: YLR337C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03119":null,"YLR337C":null},"has_protein_features":false,"name":"VRP1","ortholog_annotations":[{"gene_uniquename":"YLR337C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03119","reference_uniquename":"PMID:29761456"}],"product":"Verprolin, proline-rich actin-associated protein; involved in cytoskeletal organization and cytokinesis; promotes actin nucleation and endocytosis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004329","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR337C"}


id: YLR338W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OPI9","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C","secondary_identifier":"SGD:S000004330","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR338W"}


id: YLR339C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0","secondary_identifier":"SGD:S000004331","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR339C"}


id: YLR340W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04847":null,"YLR340W":null},"has_protein_features":false,"name":"RPP0","ortholog_annotations":[{"gene_uniquename":"YLR340W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04847","reference_uniquename":"PMID:29761456"}],"product":"Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004332","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR340W"}


id: YLR341W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPO77","product":"Meiosis-specific protein of unknown function; required for spore wall formation during sporulation and for timely prospore membrane closure along with SPS1; required with Sps1p for phosphorylation and turnover of Ssp1p; dispensable for both nuclear divisions during meiosis","secondary_identifier":"SGD:S000004333","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR341W"}


id: YLR342W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01288":null,"SJAG_02222":null,"SJAG_03587":null,"SJAG_05285":null,"YLR342W":null},"has_protein_features":false,"name":"FKS1","ortholog_annotations":[{"gene_uniquename":"YLR342W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01288","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR342W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02222","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR342W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03587","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR342W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05285","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of 1,3-beta-D-glucan synthase; transfers glucose from UDP-glucose to growing chains of glucan via β-1,3-glycosidic linkages, translocating polymerized β-1,3-glucan to the extracellular space; role in cell wall synthesis and maintenance; functionally redundant with alternate catalytic subunit Gsc2p; activity regulated by Rho1p, a subunit of the synthase complex; localizes to sites of cell wall remodeling; contains a cellulose-synthase-like fold; antifungal drug target","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004334","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR342W"}


id: YLR342W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028571","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR342W-A"}


id: YLR343W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01835":null,"YLR343W":null},"has_protein_features":false,"name":"GAS2","ortholog_annotations":[{"gene_uniquename":"YLR343W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01835","reference_uniquename":"PMID:29761456"}],"product":"1,3-beta-glucanosyltransferase; involved with Gas4p in spore wall assembly; has similarity to Gas1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004335","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR343W"}


id: YLR344W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00921":null,"YLR344W":null},"has_protein_features":false,"name":"RPL26A","ortholog_annotations":[{"gene_uniquename":"YLR344W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00921","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004336","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR344W"}


id: YLR345W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00039":null,"YLR345W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR345W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00039","reference_uniquename":"PMID:29761456"}],"product":"Similar to 6-phosphofructo-2-kinase enzymes; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004337","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR345W"}


id: YLR346C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CIS1","product":"Protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; not an essential gene; YLR346C has a paralog, YGR035C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004338","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR346C"}


id: YLR347C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01909":null,"YLR347C":null},"has_protein_features":false,"name":"KAP95","ortholog_annotations":[{"gene_uniquename":"YLR347C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01909","reference_uniquename":"PMID:29761456"}],"product":"Karyopherin beta; forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004339","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR347C"}


id: YLR347W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified ORF KAP95/YLR347C","secondary_identifier":"SGD:S000028681","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR347W-A"}


id: YLR348C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DIC1","product":"Mitochondrial dicarboxylate carrier; integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix","secondary_identifier":"SGD:S000004340","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR348C"}


id: YLR349W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C","secondary_identifier":"SGD:S000004341","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR349W"}


id: YLR350W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04550":null,"YLR350W":null},"has_protein_features":false,"name":"ORM2","ortholog_annotations":[{"gene_uniquename":"YLR350W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04550","reference_uniquename":"PMID:29761456"}],"product":"Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress; ORM2 has a paralog, ORM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004342","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR350W"}


id: YLR351C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02276":null,"YLR351C":null},"has_protein_features":false,"name":"NIT3","ortholog_annotations":[{"gene_uniquename":"YLR351C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02276","reference_uniquename":"PMID:29761456"}],"product":"Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004343","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR351C"}


id: YLR352W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LUG1","product":"Protein of unknown function with similarity to F-box proteins; interacts with the core SCF ubiquitin ligase complex subunits Skp1p and Cdc53p; LUG1 deletion prevents cells containing the [URE3] prion or lacking Ure2p from growing on glycerol","secondary_identifier":"SGD:S000004344","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR352W"}


id: YLR353W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUD8","product":"Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole; BUD8 has a paralog, BUD9, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004345","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR353W"}


id: YLR354C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04263":null,"YLR354C":null},"has_protein_features":false,"name":"TAL1","ortholog_annotations":[{"gene_uniquename":"YLR354C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04263","reference_uniquename":"PMID:29761456"}],"product":"Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate; TAL1 has a paralog, NQM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004346","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR354C"}


id: YLR355C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00396":null,"YLR355C":null},"has_protein_features":false,"name":"ILV5","ortholog_annotations":[{"gene_uniquename":"YLR355C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00396","reference_uniquename":"PMID:29761456"}],"product":"Acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004347","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR355C"}


id: YLR356W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG33","product":"Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes; ATG33 has a paralog, SCM4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004348","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR356W"}


id: YLR357W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03787":null,"YLR357W":null},"has_protein_features":false,"name":"RSC2","ortholog_annotations":[{"gene_uniquename":"YLR357W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03787","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance; RSC2 has a paralog, RSC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004349","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR357W"}


id: YLR358C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W","secondary_identifier":"SGD:S000004350","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR358C"}


id: YLR359W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02850":null,"YLR359W":null},"has_protein_features":false,"name":"ADE13","ortholog_annotations":[{"gene_uniquename":"YLR359W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02850","reference_uniquename":"PMID:29761456"}],"product":"Adenylosuccinate lyase; catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency; human ADSL can complement yeast ADE13 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004351","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR359W"}


id: YLR360W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03403":null,"YLR360W":null},"has_protein_features":false,"name":"VPS38","ortholog_annotations":[{"gene_uniquename":"YLR360W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03403","reference_uniquename":"PMID:29761456"}],"product":"Part of a Vps34p phosphatidylinositol 3-kinase complex; functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004352","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR360W"}


id: YLR361C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04262":null,"YLR361C":null},"has_protein_features":false,"name":"DCR2","ortholog_annotations":[{"gene_uniquename":"YLR361C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04262","reference_uniquename":"PMID:29761456"}],"product":"Protein phosphatase; involved in downregulation of the unfolded protein response (UPR), at least in part through dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START; physically interacts with, dephosphorylates and destabilizes Sic1p; SWAT-GFP and mCherry fusion proteins localize to the vacuole","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004353","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR361C"}


id: YLR361C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028845","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR361C-A"}


id: YLR362W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01718":null,"YLR362W":null},"has_protein_features":false,"name":"STE11","ortholog_annotations":[{"gene_uniquename":"YLR362W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01718","reference_uniquename":"PMID:29761456"}],"product":"Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004354","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR362W"}


id: YLR363C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NMD4","product":"Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","secondary_identifier":"SGD:S000004355","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR363C"}


id: YLR363W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04195":null,"YLR363W-A":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR363W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04195","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007620","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR363W-A"}


id: YLR364C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR366W","secondary_identifier":"SGD:S000028846","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR364C-A"}


id: YLR364W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GRX8","product":"Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic","secondary_identifier":"SGD:S000004356","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR364W"}


id: YLR365W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YLR365W is not an essential gene","secondary_identifier":"SGD:S000004357","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR365W"}


id: YLR366W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A","secondary_identifier":"SGD:S000004358","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR366W"}


id: YLR367W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01512":null,"SJAG_03762":null,"YLR367W":null},"has_protein_features":false,"name":"RPS22B","ortholog_annotations":[{"gene_uniquename":"YLR367W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01512","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR367W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03762","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004359","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR367W"}


id: YLR368W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MDM30","product":"F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains","secondary_identifier":"SGD:S000004360","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR368W"}


id: YLR369W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SSQ1","product":"Mitochondrial hsp70-type molecular chaperone; required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis; involved in maturation of Grx5p and Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia","secondary_identifier":"SGD:S000004361","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR369W"}


id: YLR370C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03086":null,"YLR370C":null},"has_protein_features":false,"name":"ARC18","ortholog_annotations":[{"gene_uniquename":"YLR370C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03086","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004362","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR370C"}


id: YLR371W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03705":null,"SJAG_04771":null,"YLR371W":null},"has_protein_features":false,"name":"ROM2","ortholog_annotations":[{"gene_uniquename":"YLR371W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03705","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR371W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04771","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p; ROM2 has a paralog, ROM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004363","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR371W"}


id: YLR372W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01356":null,"SJAG_02885":null,"YLR372W":null},"has_protein_features":false,"name":"ELO3","ortholog_annotations":[{"gene_uniquename":"YLR372W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01356","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR372W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02885","reference_uniquename":"PMID:29761456"}],"product":"Elongase; involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis; lethality of the elo2 elo3 double null mutation is functionally complemented by human ELOVL1 and weakly complemented by human ELOVL3 or ELOV7","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004364","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR372W"}


id: YLR373C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VID22","product":"G-quadruplex (G4) DNA binding protein; maintains genome integrity by promoting the stability of G4-DNA regions; involved in nucleosome displacement during double-strand break repair; involved in fructose-1,6-bisphosphatase (FBPase) transport from the cytosol to Vid (vacuole import and degradation) vesicles during degradation; glycosylated integral membrane protein of the plasma membrane; localizes to the nucleus; contains a BED-type zinc finger domain and a RNase H-like domain","secondary_identifier":"SGD:S000004365","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR373C"}


id: YLR374C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W","secondary_identifier":"SGD:S000004366","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR374C"}


id: YLR375W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STP3","product":"Zinc-finger protein of unknown function; possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids; STP3 has a paralog, STP4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004367","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR375W"}


id: YLR376C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02181":null,"YLR376C":null},"has_protein_features":false,"name":"PSY3","ortholog_annotations":[{"gene_uniquename":"YLR376C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02181","reference_uniquename":"PMID:29761456"}],"product":"Component of Shu complex (aka PCSS complex); Shu complex also includes Shu1, Csm2, Shu2, and promotes error-free DNA repair; promotes Rad51p filament assembly; Shu complex mediates inhibition of Srs2p function; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004368","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR376C"}


id: YLR377C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FBP1","product":"Fructose-1,6-bisphosphatase; key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; glucose starvation results in redistribution to the periplasm; interacts with Vid30p","secondary_identifier":"SGD:S000004369","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR377C"}


id: YLR378C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02330":null,"YLR378C":null},"has_protein_features":false,"name":"SEC61","ortholog_annotations":[{"gene_uniquename":"YLR378C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02330","reference_uniquename":"PMID:29761456"}],"product":"Conserved ER protein translocation channel; essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms channel for SRP-dependent protein import; with Sec63 complex is required for SRP-independent protein translocation into the ER; involved in posttranslational soluble protein import into the ER, ERAD of soluble substrates, and misfolded soluble protein export from the ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004370","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR378C"}


id: YLR379W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C","secondary_identifier":"SGD:S000004371","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR379W"}


id: YLR379W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Novel ORF identified via pan-genome analysis; conserved in other strains of S. cerevisiae","secondary_identifier":"SGD:S000303812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR379W-A"}


id: YLR380W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01225":null,"SJAG_03172":null,"SJAG_03741":null,"YLR380W":null},"has_protein_features":false,"name":"CSR1","ortholog_annotations":[{"gene_uniquename":"YLR380W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01225","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR380W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03172","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR380W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03741","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004372","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR380W"}


id: YLR381W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00684":null,"YLR381W":null},"has_protein_features":false,"name":"CTF3","ortholog_annotations":[{"gene_uniquename":"YLR381W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00684","reference_uniquename":"PMID:29761456"}],"product":"Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; required for the spindle assembly checkpoint; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004373","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR381W"}


id: YLR382C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04738":null,"YLR382C":null},"has_protein_features":false,"name":"NAM2","ortholog_annotations":[{"gene_uniquename":"YLR382C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04738","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial leucyl-tRNA synthetase; also has direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance; human homolog LARS2 can complement yeast null mutant, and is implicated in Perrault syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004374","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR382C"}


id: YLR383W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02545":null,"YLR383W":null},"has_protein_features":false,"name":"SMC6","ortholog_annotations":[{"gene_uniquename":"YLR383W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02545","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; homologous to S. pombe rad18","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004375","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR383W"}


id: YLR384C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00579":null,"YLR384C":null},"has_protein_features":false,"name":"IKI3","ortholog_annotations":[{"gene_uniquename":"YLR384C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00579","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004376","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR384C"}


id: YLR385C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SWC7","product":"Protein of unknown function; component of the Swr1p complex that incorporates Htz1p into chromatin","secondary_identifier":"SGD:S000004377","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR385C"}


id: YLR386W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01236":null,"YLR386W":null},"has_protein_features":false,"name":"VAC14","ortholog_annotations":[{"gene_uniquename":"YLR386W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01236","reference_uniquename":"PMID:29761456"}],"product":"Enzyme regulator; involved in synthesis of phosphatidylinositol 3,5-bisphosphate, in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; binds negative (Fig4p) and positive (Fab1p) regulators of PtdIns(3,5)P(2) to control endolysosome function; similar to mammalian Vac14p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR386W"}


id: YLR387C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03697":null,"YLR387C":null},"has_protein_features":false,"name":"REH1","ortholog_annotations":[{"gene_uniquename":"YLR387C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03697","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic 60S subunit biogenesis factor; associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR387C"}


id: YLR388W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03254":null,"YLR388W":null},"has_protein_features":false,"name":"RPS29A","ortholog_annotations":[{"gene_uniquename":"YLR388W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03254","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR388W"}


id: YLR389C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01430":null,"YLR389C":null},"has_protein_features":false,"name":"STE23","ortholog_annotations":[{"gene_uniquename":"YLR389C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01430","reference_uniquename":"PMID:29761456"}],"product":"Metalloprotease; involved in N-terminal processing of pro-a-factor to mature form; expressed in both haploids and diploids; one of two yeast homologs of human insulin-degrading enzyme (hIDE); homolog Axl1p is also involved in processing of pro-a-factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR389C"}


id: YLR390W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM19","product":"Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000004382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR390W"}


id: YLR390W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CCW14","product":"Covalently linked cell wall glycoprotein; present in the inner layer of the cell wall","secondary_identifier":"SGD:S000006429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR390W-A"}


id: YLR391W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YLR391W was originally annotated as an independent ORF, but was completely contained in larger ORF YLR391W-A in the same frame, and was merged into it on 7-30-1997","secondary_identifier":"SGD:S000115154","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR391W"}


id: YLR392C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ART10","product":"Protein of unknown function that contains 2 PY motifs; ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene","secondary_identifier":"SGD:S000004384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR392C"}


id: YLR393W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATP10","product":"Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase; mitochondrial inner membrane protein; interacts genetically with ATP6","secondary_identifier":"SGD:S000004385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR393W"}


id: YLR394W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CST9","product":"SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; associates with centromeres early in meiosis, then with chromosome axes and finally with double-strand break sites that are engaged in repair by crossovers; potential Cdc28p substrate","secondary_identifier":"SGD:S000004386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR394W"}


id: YLR395C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COX8","product":"Subunit VIII of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain","secondary_identifier":"SGD:S000004387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR395C"}


id: YLR396C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05194":null,"YLR396C":null},"has_protein_features":false,"name":"VPS33","ortholog_annotations":[{"gene_uniquename":"YLR396C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05194","reference_uniquename":"PMID:29761456"}],"product":"ATP-binding protein that is a subunit of the HOPS and CORVET complexes; essential for protein sorting, vesicle docking, and fusion at the vacuole; binds to SNARE domains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR396C"}


id: YLR397C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00390":null,"YLR397C":null},"has_protein_features":false,"name":"AFG2","ortholog_annotations":[{"gene_uniquename":"YLR397C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00390","reference_uniquename":"PMID:29761456"}],"product":"ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; target of the ribosomal biosynthesis inhibitor diazaborine; may be involved in degradation of aberrant mRNAs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR397C"}


id: YLR398C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04118":null,"YLR398C":null},"has_protein_features":false,"name":"SKI2","ortholog_annotations":[{"gene_uniquename":"YLR398C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04118","reference_uniquename":"PMID:29761456"}],"product":"Ski complex component and putative RNA helicase; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, SKIV2L, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR398C"}


id: YLR399C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02500":null,"SJAG_02701":null,"YLR399C":null},"has_protein_features":false,"name":"BDF1","ortholog_annotations":[{"gene_uniquename":"YLR399C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02500","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR399C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02701","reference_uniquename":"PMID:29761456"}],"product":"BET family transcriptional regulator; associates with TFIID, and is involved in transcription initiation at TATA-containing promoters; essential for meiosis and expression of meiosis-specific genes;  binds acetylated histone H4 at double-strand break (DSB) sites, and promotes end resection, loading of RPA and Rad51p and ds break repair by homologous recombination; contains two bromodomains that correspond to the C-terminal region of mammalian TAF1; partially redundant with paralog Bdf2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR399C"}


id: YLR399W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the characterized ORF BDF1/YLR399C","secondary_identifier":"SGD:S000028682","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR399W-A"}


id: YLR400W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR400W"}


id: YLR401C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03240":null,"YLR401C":null},"has_protein_features":false,"name":"DUS3","ortholog_annotations":[{"gene_uniquename":"YLR401C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03240","reference_uniquename":"PMID:29761456"}],"product":"Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; modifies pre-tRNAs at U47 of the variable arm; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR401C"}


id: YLR402W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004394","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR402W"}


id: YLR403W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03241":null,"YLR403W":null},"has_protein_features":false,"name":"SFP1","ortholog_annotations":[{"gene_uniquename":"YLR403W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03241","reference_uniquename":"PMID:29761456"}],"product":"Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004395","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR403W"}


id: YLR404W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01537":null,"YLR404W":null},"has_protein_features":false,"name":"SEI1","ortholog_annotations":[{"gene_uniquename":"YLR404W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01537","reference_uniquename":"PMID:29761456"}],"product":"Seipin involved in lipid droplet (LD) assembly; controls lipid particle morphology, number, and size; promotes initiation of LD formation on the ER; ensures that LDs bud from the ER towards the cytosolic side of the membrane; forms a complex with Ldb16p at ER-LD contact sites, stabilizing these sites; null mutants have localized accumulation of phosphatidic acid (PA) marker proteins; BSCL2, human homolog implicated in congenital lipodystrophy, complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004396","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR404W"}


id: YLR405W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01041":null,"YLR405W":null},"has_protein_features":false,"name":"DUS4","ortholog_annotations":[{"gene_uniquename":"YLR405W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01041","reference_uniquename":"PMID:29761456"}],"product":"Dihydrouridine synthase; modifies pre-tRNAs at U20a and U20b of the D loop; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004397","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR405W"}


id: YLR406C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01676":null,"SJAG_02755":null,"YLR406C":null},"has_protein_features":false,"name":"RPL31B","ortholog_annotations":[{"gene_uniquename":"YLR406C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01676","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR406C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02755","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004398","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR406C"}


id: YLR406C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole","secondary_identifier":"SGD:S000028683","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR406C-A"}


id: YLR407W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00347":null,"YLR407W":null},"has_protein_features":false,"name":"GAG1","ortholog_annotations":[{"gene_uniquename":"YLR407W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00347","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus; Interacts with CKA2 in a potentially competitive mode with the CK2 holoenzyme. Structural prediction analysis reveals a clamp-domain (rear, hinge, front), an unstructured gag region, and a lock-domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004399","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR407W"}


id: YLR408C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BLS1","product":"Subunit of the BLOC-1 complex involved in endosomal maturation; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene","secondary_identifier":"SGD:S000004400","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR408C"}


id: YLR409C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00245":null,"YLR409C":null},"has_protein_features":false,"name":"UTP21","ortholog_annotations":[{"gene_uniquename":"YLR409C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00245","reference_uniquename":"PMID:29761456"}],"product":"Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma; Small Subunit processome is also known as SSU processome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004401","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR409C"}


id: YLR410W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00244":null,"YLR410W":null},"has_protein_features":false,"name":"VIP1","ortholog_annotations":[{"gene_uniquename":"YLR410W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00244","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional inositol pyrophosphate kinase and phosphatase; contains an N-terminal PP-InsP kinase domain that phosphorylates inositol hexakisphosphate and heptakisphosphate, and a C-terminal phosphatase domain that hydrolyzes both 1PP-InsP5 and 5PP-InsP5; IP7 levels decrease during starvation, suggesting a role for PP-InsP enzymes in Pi homeostasis; may regulate the dimorphic switch and the function of the cortical actin cytoskeleton","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004402","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR410W"}


id: YLR411W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01493":null,"SJAG_04246":null,"YLR411W":null},"has_protein_features":false,"name":"CTR3","ortholog_annotations":[{"gene_uniquename":"YLR411W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01493","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR411W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04246","reference_uniquename":"PMID:29761456"}],"product":"High-affinity copper transporter of the plasma membrane; acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004403","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR411W"}


id: YLR412C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028572","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR412C-A"}


id: YLR412W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02069":null,"YLR412W":null},"has_protein_features":false,"name":"BER1","ortholog_annotations":[{"gene_uniquename":"YLR412W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02069","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in microtubule-related processes; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004404","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR412W"}


id: YLR413W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"INA1","product":"Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004405","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR413W"}


id: YLR414C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04620":null,"YLR414C":null},"has_protein_features":false,"name":"PUN1","ortholog_annotations":[{"gene_uniquename":"YLR414C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04620","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004406","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR414C"}


id: YLR415C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YLR415C is not an essential gene","secondary_identifier":"SGD:S000004407","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR415C"}


id: YLR416C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004408","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR416C"}


id: YLR417W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04024":null,"YLR417W":null},"has_protein_features":false,"name":"VPS36","ortholog_annotations":[{"gene_uniquename":"YLR417W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04024","reference_uniquename":"PMID:29761456"}],"product":"Component of ESCRT-II complex; contains GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into endosome; plays role in lager yeast flocculation under brewing conditions; plays role in formation of mutant huntingtin (Htt) aggregates in yeast","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004409","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR417W"}


id: YLR418C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01151":null,"YLR418C":null},"has_protein_features":false,"name":"CDC73","ortholog_annotations":[{"gene_uniquename":"YLR418C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01151","reference_uniquename":"PMID:29761456"}],"product":"Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; role in preventing L-A mycovirus pathogenesis; protein abundance increases in response to DNA replication stress; human homolog, parafibromin, is a tumour suppressor linked to breast, renal and gastric cancers","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004410","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR418C"}


id: YLR419W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02061":null,"SJAG_03533":null,"YLR419W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR419W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02061","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLR419W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03533","reference_uniquename":"PMID:29761456"}],"product":"Predicted RNA helicase of the DEAH-box family; the authentic, non-tagged protein is detected in highly purified mitochondria in HTP studies and sediments with the 40S ribosomal subunit; crosslinks with 18S rRNA; non-essential gene; contains a ubiquitin-associated domain, an RWD domain, a helicase ATP-binding DEAD-like domain, a helicase C terminal domain and a helicase associated domain; does not contain a Rb-like A/B pocket structure; homolog of mammalian translation initiation factor DHX29","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004411","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR419W"}


id: YLR420W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00444":null,"YLR420W":null},"has_protein_features":false,"name":"URA4","ortholog_annotations":[{"gene_uniquename":"YLR420W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00444","reference_uniquename":"PMID:29761456"}],"product":"Dihydroorotase; catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004412","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR420W"}


id: YLR421C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04211":null,"SJAG_04484":null,"YLR421C":null},"has_protein_features":false,"name":"RPN13","ortholog_annotations":[{"gene_uniquename":"YLR421C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04211","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR421C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04484","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004413","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR421C"}


id: YLR422W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DCK1","product":"Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1; upstream component for regulation through the small GTPase Rho5p; may form a complex with Lmo1p that acts as a GEF for Rho5p; interacts with Ino4p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein; DOCK proteins act as guanine nucleotide exchange factors","secondary_identifier":"SGD:S000004414","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR422W"}


id: YLR423C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05017":null,"YLR423C":null},"has_protein_features":false,"name":"ATG17","ortholog_annotations":[{"gene_uniquename":"YLR423C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05017","reference_uniquename":"PMID:29761456"}],"product":"Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004415","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR423C"}


id: YLR424W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03301":null,"YLR424W":null},"has_protein_features":false,"name":"SPP382","ortholog_annotations":[{"gene_uniquename":"YLR424W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03301","reference_uniquename":"PMID:29761456"}],"product":"Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004416","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR424W"}


id: YLR425W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03704":null,"YLR425W":null},"has_protein_features":false,"name":"TUS1","ortholog_annotations":[{"gene_uniquename":"YLR425W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03704","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004417","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR425W"}


id: YLR426W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00593":null,"YLR426W":null},"has_protein_features":false,"name":"TDA5","ortholog_annotations":[{"gene_uniquename":"YLR426W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00593","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004418","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR426W"}


id: YLR427W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02415":null,"YLR427W":null},"has_protein_features":false,"name":"MAG2","ortholog_annotations":[{"gene_uniquename":"YLR427W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02415","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004419","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR427W"}


id: YLR428C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1","secondary_identifier":"SGD:S000004420","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR428C"}


id: YLR429W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00677":null,"YLR429W":null},"has_protein_features":false,"name":"CRN1","ortholog_annotations":[{"gene_uniquename":"YLR429W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00677","reference_uniquename":"PMID:29761456"}],"product":"Coronin; cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR429W"}


id: YLR430W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02242":null,"SJAG_03923":null,"YLR430W":null},"has_protein_features":false,"name":"SEN1","ortholog_annotations":[{"gene_uniquename":"YLR430W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02242","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR430W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03923","reference_uniquename":"PMID:29761456"}],"product":"ATP-dependent 5' to 3' RNA/DNA and DNA helicase; subunit of the exosome-associated Nrd1p complex that mediates 3' end formation of snRNAs, snoRNAs, CUTs and some mRNAs; helicase-independent role in transcription-coupled repair; coordinates replication with transcription, associating with moving forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of juvenile ALS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR430W"}


id: YLR431C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG23","product":"Peripheral membrane protein required for autophagy and CVT; required for cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p","secondary_identifier":"SGD:S000004423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR431C"}


id: YLR432W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01298":null,"YLR432W":null},"has_protein_features":false,"name":"IMD3","ortholog_annotations":[{"gene_uniquename":"YLR432W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01298","reference_uniquename":"PMID:29761456"}],"product":"Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD3 has a paralog, IMD4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004424","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR432W"}


id: YLR433C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03631":null,"YLR433C":null},"has_protein_features":false,"name":"CNA1","ortholog_annotations":[{"gene_uniquename":"YLR433C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03631","reference_uniquename":"PMID:29761456"}],"product":"Calcineurin A; one isoform (the other is Cmp2p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CNA1 has a paralog, CMP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR433C"}


id: YLR434C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W","secondary_identifier":"SGD:S000004426","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR434C"}


id: YLR435W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02358":null,"YLR435W":null},"has_protein_features":false,"name":"TSR2","ortholog_annotations":[{"gene_uniquename":"YLR435W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02358","reference_uniquename":"PMID:29761456"}],"product":"Protein with a potential role in pre-rRNA processing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004427","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR435W"}


id: YLR436C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00567":null,"SJAG_03278":null,"SJAG_03634":null,"YLR436C":null},"has_protein_features":false,"name":"ECM30","ortholog_annotations":[{"gene_uniquename":"YLR436C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00567","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR436C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03278","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR436C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03634","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004428","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR436C"}


id: YLR437C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01348":null,"SJAG_02874":null,"YLR437C":null},"has_protein_features":false,"name":"DIF1","ortholog_annotations":[{"gene_uniquename":"YLR437C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01348","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR437C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02874","reference_uniquename":"PMID:29761456"}],"product":"Protein that regulates nuclear import of Rnr2p and Rnr4p; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half shows similarity to S. pombe Spd1 protein; DIF1 has a paralog, SML1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR437C"}


id: YLR437C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W","secondary_identifier":"SGD:S000028684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR437C-A"}


id: YLR438C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03460":null,"YLR438C-A":null},"has_protein_features":false,"name":"LSM3","ortholog_annotations":[{"gene_uniquename":"YLR438C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03460","reference_uniquename":"PMID:29761456"}],"product":"Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR438C-A"}


id: YLR438W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00495":null,"YLR438W":null},"has_protein_features":false,"name":"CAR2","ortholog_annotations":[{"gene_uniquename":"YLR438W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00495","reference_uniquename":"PMID:29761456"}],"product":"L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004430","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR438W"}


id: YLR439W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01045":null,"YLR439W":null},"has_protein_features":false,"name":"MRPL4","ortholog_annotations":[{"gene_uniquename":"YLR439W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01045","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR439W"}


id: YLR440C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04956":null,"YLR440C":null},"has_protein_features":false,"name":"SEC39","ortholog_annotations":[{"gene_uniquename":"YLR440C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04956","reference_uniquename":"PMID:29761456"}],"product":"Component of the Dsl1p tethering complex; this complex interacts with ER SNAREs Sec20p and Use1p; mediates Sey1p-independent homotypic ER fusion; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004432","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR440C"}


id: YLR441C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00733":null,"SJAG_02522":null,"YLR441C":null},"has_protein_features":false,"name":"RPS1A","ortholog_annotations":[{"gene_uniquename":"YLR441C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00733","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR441C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02522","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004433","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR441C"}


id: YLR442C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SIR3","product":"Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; required for telomere hypercluster formation in quiescent yeast cells; has paralog ORC1 from whole genome duplication","secondary_identifier":"SGD:S000004434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR442C"}


id: YLR443W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM7","product":"Putative integral membrane protein with a role in calcium uptake; non-essential protein; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency","secondary_identifier":"SGD:S000004435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR443W"}


id: YLR444C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004436","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR444C"}


id: YLR445W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GMC2","product":"Protein involved in meiotic crossing over; component of the Synaptonemal Complex (SC) along with Ecm11p; required for the efficient loading of the SC transverse filament protein, Zip1p; promotes SUMOylation of Ecm11p; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor; also detected in peroxisomes","secondary_identifier":"SGD:S000004437","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR445W"}


id: YLR446W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NGK1","product":"N-acetylglucosamine (GlcNAc) kinase; requires a divalent cation and a broad range of NTPs as phosphoryl donor to generate GlcNAc-6-phosphate, a substrate for glycan biosynthesis; promotes UDP-GlcNAc biosynthesis a precursor for chitin production; phylogenically distinct from known GlcNAc kinases and hexokinases; transcript is upregulated during sporulation and the unfolded protein response; contains a hexokinase-like ATPase domain; non-essential gene","secondary_identifier":"SGD:S000004438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR446W"}


id: YLR447C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01913":null,"YLR447C":null},"has_protein_features":false,"name":"VMA6","ortholog_annotations":[{"gene_uniquename":"YLR447C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01913","reference_uniquename":"PMID:29761456"}],"product":"Subunit d of the V0 integral membrane domain of V-ATPase; part of the electrogenic proton pump found in the endomembrane system; required for V1 domain assembly on the vacuolar membrane; the V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase) has five subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR447C"}


id: YLR448W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03666":null,"YLR448W":null},"has_protein_features":false,"name":"RPL6B","ortholog_annotations":[{"gene_uniquename":"YLR448W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03666","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004440","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR448W"}


id: YLR449W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01005":null,"SJAG_03905":null,"YLR449W":null},"has_protein_features":false,"name":"FPR4","ortholog_annotations":[{"gene_uniquename":"YLR449W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01005","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR449W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03905","reference_uniquename":"PMID:29761456"}],"product":"Nuclear peptidyl-prolyl cis-trans isomerase (PPIase); impacts expression of multiple genes via its role in nucleosome assembly; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones; role in rDNA maintenance; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; contains a nucleoplasmin-like fold and can form pentamers","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR449W"}


id: YLR450W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03715":null,"YLR450W":null},"has_protein_features":false,"name":"HMG2","ortholog_annotations":[{"gene_uniquename":"YLR450W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03715","reference_uniquename":"PMID:29761456"}],"product":"HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at nuclear periphery upon DNA replication stress; primarily expressed on the peri-membrane side of the ER; human homolog HMGCR can complement yeast hmg2 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004442","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR450W"}


id: YLR451W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LEU3","product":"Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation","secondary_identifier":"SGD:S000004443","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR451W"}


id: YLR452C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00990":null,"YLR452C":null},"has_protein_features":false,"name":"SST2","ortholog_annotations":[{"gene_uniquename":"YLR452C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00990","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein for Gpa1p; regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004444","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR452C"}


id: YLR453C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RIF2","product":"Protein that binds to the Rap1p C-terminus; inhibits MRX-dependent Tel1p activity by acting directly on Rad50p and discharging its activated ATP-bound state, thereby rendering the MRX complex incompetent for Tel1p activation; acts synergistically with Rif1p to help control telomere length, establish telomeric silencing; deletion results in telomere elongation; RIF2 has paralog ORC4 that arose from the whole genome duplication","secondary_identifier":"SGD:S000004445","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR453C"}


