# genes

id: YFR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PES4","product":"Putative RNA binding protein; partially redundant function with paralog MIP6 in the steady-state expression, translational timing and localization of a subset of Ndt80-dependent mRNAs that are protected until translated near the end of meiosis II; regulator of meiotic commitment; redundant function with MIP6 in sporulation; localizes to puncta near the openings of the prospore membrane; suppressor of a DNA polymerase epsilon mutation; induced by NDT80","secondary_identifier":"SGD:S000001919","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR023W"}


id: YFR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a discrete protein; YFR024C was originally annotated as a separate ORF, but was later removed because it was demonstrated to be theC-terminus of LSB3/YFR024C-A","secondary_identifier":"SGD:S000001920","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR024C"}


id: YFR024C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00970":null,"YFR024C-A":null},"has_protein_features":false,"name":"LSB3","ortholog_annotations":[{"gene_uniquename":"YFR024C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00970","reference_uniquename":"PMID:29761456"}],"product":"Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002968","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR024C-A"}


id: YFR025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00248":null,"YFR025C":null},"has_protein_features":false,"name":"HIS2","ortholog_annotations":[{"gene_uniquename":"YFR025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00248","reference_uniquename":"PMID:29761456"}],"product":"Histidinolphosphatase; catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001921","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR025C"}


id: YFR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ULI1","product":"Protein of unknown function; involved in and induced by the endoplasmic reticulum unfolded protein response (UPR); SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum","secondary_identifier":"SGD:S000001922","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR026C"}


id: YFR027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04791":null,"YFR027W":null},"has_protein_features":false,"name":"ECO1","ortholog_annotations":[{"gene_uniquename":"YFR027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04791","reference_uniquename":"PMID:29761456"}],"product":"Acetyltransferase required for sister chromatid cohesion; elicits cohesin dimerization during S phase; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by Cdc28p, Cdc7p, Mck1p to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; relative distribution to nucleus increases upon DNA replication stress; mutations in human homolog ESCO2 cause Roberts syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001923","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR027W"}


id: YFR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00082":null,"YFR028C":null},"has_protein_features":false,"name":"CDC14","ortholog_annotations":[{"gene_uniquename":"YFR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00082","reference_uniquename":"PMID:29761456"}],"product":"Protein phosphatase required for mitotic exit; required for rDNA segregation, cytokinesis, meiosis I spindle disassembly, environmental stress response, autophagy during meiosis; downregulates microautophagy induction after TORC1 inactivation; held in nucleolus by Cdc55p in early meiosis, liberated by FEAR and Mitotic Exit Network in anaphase; sequestered in metaphase II, released upon entry into anaphase II; human homolog CDC14A can complement thermosensitivity of cdc14-1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001924","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR028C"}


id: YFR029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PTR3","product":"Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p","secondary_identifier":"SGD:S000001925","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR029W"}


id: YFR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01693":null,"YFR030W":null},"has_protein_features":false,"name":"MET10","ortholog_annotations":[{"gene_uniquename":"YFR030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01693","reference_uniquename":"PMID:29761456"}],"product":"Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001926","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR030W"}


id: YFR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03832":null,"YFR031C":null},"has_protein_features":false,"name":"SMC2","ortholog_annotations":[{"gene_uniquename":"YFR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03832","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; essential SMC chromosomal ATPase family member that forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for clustering of tRNA genes at the nucleolus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001927","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR031C"}


id: YFR031C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00034":null,"SJAG_02312":null,"YFR031C-A":null},"has_protein_features":false,"name":"RPL2A","ortholog_annotations":[{"gene_uniquename":"YFR031C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR031C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02312","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002104","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR031C-A"}


id: YFR032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRT5","product":"Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation","secondary_identifier":"SGD:S000001928","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR032C"}


id: YFR032C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03127":null,"YFR032C-A":null},"has_protein_features":false,"name":"RPL29","ortholog_annotations":[{"gene_uniquename":"YFR032C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03127","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006437","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR032C-A"}


id: YFR032C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIN10","product":"Mitochondrial protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR032C-B"}


id: YFR033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01490":null,"YFR033C":null},"has_protein_features":false,"name":"QCR6","ortholog_annotations":[{"gene_uniquename":"YFR033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01490","reference_uniquename":"PMID:29761456"}],"product":"Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001929","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR033C"}


id: YFR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PHO4","product":"Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p; function is regulated by phosphorylation at multiple sites and by phosphate availability","secondary_identifier":"SGD:S000001930","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR034C"}


id: YFR034W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps YFR035C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR034W-A"}


id: YFR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; deletion mutant exhibits synthetic phenotype with alpha-synuclein","secondary_identifier":"SGD:S000001931","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR035C"}


id: YFR035W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; added to genome annotation based on evolutionary, translation, and proteomics evidence","secondary_identifier":"SGD:S000350095","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR035W-A"}


id: YFR036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01801":null,"YFR036W":null},"has_protein_features":false,"name":"CDC26","ortholog_annotations":[{"gene_uniquename":"YFR036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01801","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001932","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR036W"}


id: YFR036W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps verified ORF RSC8/YFR037C","secondary_identifier":"SGD:S000028767","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR036W-A"}


id: YFR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02589":null,"YFR037C":null},"has_protein_features":false,"name":"RSC8","ortholog_annotations":[{"gene_uniquename":"YFR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02589","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001933","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR037C"}


id: YFR038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC5","product":"Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci; SWAT-GFP and mCherry fusion proteins localize to the nucleus","secondary_identifier":"SGD:S000001934","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR038W"}


id: YFR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OSW7","product":"Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; may be involved in response to high salt and changes in carbon source; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; deletion mutant has decreased spore survival in Drosophila feces; OSW7 has a paralog, SHE10, that arose from the whole genome duplication; paralogs are redundant for spore wall dityrosine assembly","secondary_identifier":"SGD:S000001935","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR039C"}


id: YFR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04638":null,"YFR040W":null},"has_protein_features":false,"name":"SAP155","ortholog_annotations":[{"gene_uniquename":"YFR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04638","reference_uniquename":"PMID:29761456"}],"product":"Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress; SAP155 has a paralog, SAP4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001936","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR040W"}


id: YFR041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03030":null,"YFR041C":null},"has_protein_features":false,"name":"ERJ5","ortholog_annotations":[{"gene_uniquename":"YFR041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03030","reference_uniquename":"PMID:29761456"}],"product":"Type I membrane protein with a J domain; required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001937","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR041C"}


id: YFR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"KEG1","product":"Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability","secondary_identifier":"SGD:S000001938","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR042W"}


id: YFR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05011":null,"YFR043C":null},"has_protein_features":false,"name":"IRC6","ortholog_annotations":[{"gene_uniquename":"YFR043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05011","reference_uniquename":"PMID:29761456"}],"product":"Clathrin coat accessory factor; involved in clathrin-mediated vesicle trafficking; may function to link the AP-1 clathrin adaptor complex with the Rab GTPase Ypt31p; has structural similarity to G-proteins; mouse homolog Aagab (p34) functionally complements irc6 null mutation; null mutant displays increased levels of spontaneous Rad52p foci","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001939","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR043C"}


id: YFR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04858":null,"YFR044C":null},"has_protein_features":false,"name":"DUG1","ortholog_annotations":[{"gene_uniquename":"YFR044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04858","reference_uniquename":"PMID:29761456"}],"product":"Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); human homolog CNDP2 can complement yeast dug1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001940","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR044C"}


id: YFR045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRX20","product":"Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white","secondary_identifier":"SGD:S000001941","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR045W"}


id: YFR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02513":null,"YFR046C":null},"has_protein_features":false,"name":"CNN1","ortholog_annotations":[{"gene_uniquename":"YFR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02513","reference_uniquename":"PMID:29761456"}],"product":"Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001942","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR046C"}


id: YFR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BNA6","product":"Quinolinate phosphoribosyl transferase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p","secondary_identifier":"SGD:S000001943","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR047C"}


id: YFR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01174":null,"SJAG_02548":null,"YFR048W":null},"has_protein_features":false,"name":"RMD8","ortholog_annotations":[{"gene_uniquename":"YFR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01174","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02548","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic protein required for sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001944","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR048W"}


id: YFR049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06382":null,"YFR049W":null},"has_protein_features":false,"name":"KGD4","ortholog_annotations":[{"gene_uniquename":"YFR049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06382","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase; recruits E3 subunit (Lpd1p) to the E1-E2 (Kgd1p, Kgd2p) core; exists in two forms derived from a single mRNA translated from two alternative start sites; evolutionarily conserved role in the organization of mitochondrial α-KGDH complexes; homolog of human KGD4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001945","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR049W"}


id: YFR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04541":null,"YFR050C":null},"has_protein_features":false,"name":"PRE4","ortholog_annotations":[{"gene_uniquename":"YFR050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04541","reference_uniquename":"PMID:29761456"}],"product":"Beta 7 subunit of the 20S proteasome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001946","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR050C"}


id: YFR051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02482":null,"YFR051C":null},"has_protein_features":false,"name":"RET2","ortholog_annotations":[{"gene_uniquename":"YFR051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02482","reference_uniquename":"PMID:29761456"}],"product":"Delta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001947","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR051C"}


id: YFR052C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF HXK1/YFR053C","secondary_identifier":"SGD:S000028768","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR052C-A"}


id: YFR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01203":null,"YFR052W":null},"has_protein_features":false,"name":"RPN12","ortholog_annotations":[{"gene_uniquename":"YFR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01203","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001948","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR052W"}


id: YFR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04334":null,"YFR053C":null},"has_protein_features":false,"name":"HXK1","ortholog_annotations":[{"gene_uniquename":"YFR053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04334","reference_uniquename":"PMID:29761456"}],"product":"Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001949","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR053C"}


id: YFR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000001950","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR054C"}


id: YFR055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC7","product":"Cysteine desulphydrase, enables growth on cysteine as nitrogen source; involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner","secondary_identifier":"SGD:S000001952","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR055W"}


id: YFR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W","secondary_identifier":"SGD:S000001951","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR056C"}


id: YFR057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Telomere-linked gene, silencing of which is strictly Sir2-dependent","secondary_identifier":"SGD:S000001953","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR057W"}


id: YGL001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02855":null,"YGL001C":null},"has_protein_features":false,"name":"ERG26","ortholog_annotations":[{"gene_uniquename":"YGL001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02855","reference_uniquename":"PMID:29761456"}],"product":"C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; human homolog NSDHL implicated in CK syndrome, and can complement yeast null mutant; molecular target of natural product and antifungal compound FR171456","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002969","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL001C"}


id: YGL002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04598":null,"YGL002W":null},"has_protein_features":false,"name":"ERP6","ortholog_annotations":[{"gene_uniquename":"YGL002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04598","reference_uniquename":"PMID:29761456"}],"product":"Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002970","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL002W"}


id: YGL003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00071":null,"SJAG_04853":null,"YGL003C":null},"has_protein_features":false,"name":"CDH1","ortholog_annotations":[{"gene_uniquename":"YGL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00071","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04853","reference_uniquename":"PMID:29761456"}],"product":"Activator of anaphase-promoting complex/cyclosome (APC/C); antagonist of the spindle assembly checkpoint; directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including: Cdc20p, Ase1p, Cin8p, Fin1p and Clb5p; partially active in metaphase, and fully active in anaphase; cell-cycle regulated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002971","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL003C"}


id: YGL004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RPN14","product":"Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p","secondary_identifier":"SGD:S000002972","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL004C"}


id: YGL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COG7","product":"Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments","secondary_identifier":"SGD:S000002973","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL005C"}


id: YGL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01400":null,"YGL006W":null},"has_protein_features":false,"name":"PMC1","ortholog_annotations":[{"gene_uniquename":"YGL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01400","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in presence of elevated concentrations of calcium; targeted to vacuole via AP-3 pathway; similar to mammalian PMCA1a","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002974","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL006W"}


id: YGL006W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by SAGE","secondary_identifier":"SGD:S000028769","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL006W-A"}


id: YGL007C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding","secondary_identifier":"SGD:S000028632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL007C-A"}


id: YGL007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BRP1","product":"Putative protein of unknown function; located in the upstream region of PMA1; conserved among S. cerevisiae strains; mediates the cycloheximide-induced degradation of ubiquitinated Agp2p, a regulator of high affinity polyamine and carnitine transport; null mutant is polyamine resistant due to downregulation of PMA1","secondary_identifier":"SGD:S000002975","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL007W"}


id: YGL008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01129":null,"SJAG_01669":null,"SJAG_04258":null,"YGL008C":null},"has_protein_features":false,"name":"PMA1","ortholog_annotations":[{"gene_uniquename":"YGL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01129","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01669","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04258","reference_uniquename":"PMID:26896847"}],"product":"Plasma membrane P2-type H+-ATPase; pumps protons out of cell; major regulator of cytoplasmic pH and plasma membrane potential; long-lived hexameric protein asymmetrically distributed at plasma membrane between mother cells and buds; accumulates at high levels in mother cells during aging, buds emerge with very low levels of Pma1p, newborn cells have low levels of Pma1p; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002976","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL008C"}


id: YGL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03243":null,"YGL009C":null},"has_protein_features":false,"name":"LEU1","ortholog_annotations":[{"gene_uniquename":"YGL009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03243","reference_uniquename":"PMID:29761456"}],"product":"Isopropylmalate isomerase; catalyzes the second step in the leucine biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002977","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL009C"}


id: YGL010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00519":null,"YGL010W":null},"has_protein_features":false,"name":"MPO1","ortholog_annotations":[{"gene_uniquename":"YGL010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00519","reference_uniquename":"PMID:29761456"}],"product":"Dioxygenase that catalyzes alpha-oxygenation of 2-hydroxy fatty acids; involved in metabolism of phytosphingosine; not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002978","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL010W"}


id: YGL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02562":null,"YGL011C":null},"has_protein_features":false,"name":"SCL1","ortholog_annotations":[{"gene_uniquename":"YGL011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02562","reference_uniquename":"PMID:29761456"}],"product":"Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002979","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL011C"}


id: YGL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03024":null,"YGL012W":null},"has_protein_features":false,"name":"ERG4","ortholog_annotations":[{"gene_uniquename":"YGL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03024","reference_uniquename":"PMID:29761456"}],"product":"C-24(28) sterol reductase; catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002980","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL012W"}


id: YGL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PDR1","product":"Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; relocalizes to the cytosol in response to hypoxia; PDR1 has a paralog, PDR3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002981","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL013C"}


id: YGL014C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028825","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL014C-A"}


id: YGL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02239":null,"SJAG_05322":null,"YGL014W":null},"has_protein_features":false,"name":"PUF4","ortholog_annotations":[{"gene_uniquename":"YGL014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02239","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05322","reference_uniquename":"PMID:29761456"}],"product":"Member of the PUF protein family; PUF family is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002982","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL014W"}


id: YGL015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BIL2","product":"Formin inhibitor; inhibits Bnr1p-mediated actin filament nucleation but not elongation during vegetative growth; performs distinct but overlapping roles with Hof1p to control actin cable assembly and polarized secretion; spatially focuses Bni1p at mating projection tips, and with Bud6p organizes Bni1p into clusters that nucleate actin assembly during mating projection formation; bnr1 bil2 double mutants are inviable; localizes to the cytosol, secretory vesicles and sites of polarized growth","secondary_identifier":"SGD:S000002983","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL015C"}


id: YGL016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00968":null,"YGL016W":null},"has_protein_features":false,"name":"KAP122","ortholog_annotations":[{"gene_uniquename":"YGL016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00968","reference_uniquename":"PMID:29761456"}],"product":"Karyopherin beta; bidirectional nuclear transport receptor (biportin) that shuttles distinct sets of cargoes in opposite directions; responsible for import of Toa1p-Toa2p complex into nucleus; depletes eIF5A and eEF2 from cell nuclei; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002984","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL016W"}


id: YGL017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02705":null,"YGL017W":null},"has_protein_features":false,"name":"ATE1","ortholog_annotations":[{"gene_uniquename":"YGL017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02705","reference_uniquename":"PMID:29761456"}],"product":"Arginyl-tRNA-protein transferase; catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway; may have a role in regulating stress response","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002985","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL017W"}


id: YGL018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00066":null,"YGL018C":null},"has_protein_features":false,"name":"JAC1","ortholog_annotations":[{"gene_uniquename":"YGL018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00066","reference_uniquename":"PMID:29761456"}],"product":"Specialized J-protein that functions in Fe-S cluster biogenesis; functions with Hsp70 in Fe-S cluster biogenesis in mitochondria; involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002986","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL018C"}


id: YGL019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00142":null,"SJAG_03931":null,"YGL019W":null},"has_protein_features":false,"name":"CKB1","ortholog_annotations":[{"gene_uniquename":"YGL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00142","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03931","reference_uniquename":"PMID:29761456"}],"product":"Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002987","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL019W"}


id: YGL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01178":null,"YGL020C":null},"has_protein_features":false,"name":"GET1","ortholog_annotations":[{"gene_uniquename":"YGL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01178","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the GET complex; involved in insertion of tail-anchored proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance; Get1p and Get2p form an aqueous channel for protein translocation and insertion into the membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002988","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL020C"}


id: YGL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00678":null,"YGL021W":null},"has_protein_features":false,"name":"ALK1","ortholog_annotations":[{"gene_uniquename":"YGL021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00678","reference_uniquename":"PMID:29761456"}],"product":"Atypical protein kinase; along with paralog, ALK2, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of formins and polarisome components in mitosis, and survival after spindle assembly checkpoint delay; regulates the morphogenesis checkpoint in response to polarity insults through inactivation of Mih1p; phosphorylated in response to DNA damage; similar to mammalian haspins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002989","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL021W"}


id: YGL022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04127":null,"YGL022W":null},"has_protein_features":false,"name":"STT3","ortholog_annotations":[{"gene_uniquename":"YGL022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04127","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of the oligosaccharyltransferase (OST) complex; the OST complex catalyzes asparagine-linked glycosylation of newly synthesized proteins in the ER lumen; involved in recognition of N-acetylglucosamine; forms a subcomplex with Ost3p and Ost4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002990","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL022W"}


id: YGL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03405":null,"YGL023C":null},"has_protein_features":false,"name":"PIB2","ortholog_annotations":[{"gene_uniquename":"YGL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03405","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol 3-phosphate binding protein; forms a distinct complex with TORC1, induced by glutamine in a dose-dependent manner, resulting in TORC1 activation, suggesting dual roles as both a glutamine sensor and a direct TORC1 activator; functions as a cysteine sensor involved in TORC1 activation; involved in leucine- and glutamine-responsive TORC1 activation, independent of the Gtr/Ego pathway; related to human PLEKHF1; contains a PI3P binding FYVE domain; similar to Fab1p and Vps27p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002991","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL023C"}


id: YGL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF PGD1/YGL025C","secondary_identifier":"SGD:S000002992","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL024W"}


id: YGL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PGD1","product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor","secondary_identifier":"SGD:S000002993","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL025C"}


id: YGL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05007":null,"YGL026C":null},"has_protein_features":false,"name":"TRP5","ortholog_annotations":[{"gene_uniquename":"YGL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05007","reference_uniquename":"PMID:29761456"}],"product":"Tryptophan synthase; catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002994","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL026C"}


id: YGL027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04363":null,"YGL027C":null},"has_protein_features":false,"name":"CWH41","ortholog_annotations":[{"gene_uniquename":"YGL027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04363","reference_uniquename":"PMID:29761456"}],"product":"Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002995","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL027C"}


id: YGL028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SCW11","product":"Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p","secondary_identifier":"SGD:S000002996","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL028C"}


id: YGL029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01674":null,"YGL029W":null},"has_protein_features":false,"name":"CGR1","ortholog_annotations":[{"gene_uniquename":"YGL029W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01674","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in nucleolar integrity and processing of pre-rRNA; has a role in processing rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress; relocalizes from nucleus to nucleolus upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002997","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL029W"}


id: YGL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03383":null,"YGL030W":null},"has_protein_features":false,"name":"RPL30","ortholog_annotations":[{"gene_uniquename":"YGL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03383","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002998","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL030W"}


id: YGL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02243":null,"SJAG_03922":null,"YGL031C":null},"has_protein_features":false,"name":"RPL24A","ortholog_annotations":[{"gene_uniquename":"YGL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02243","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03922","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L24A; forms two bridges within ribosome, stimulates translation initiation and elongation; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002999","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL031C"}


id: YGL032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AGA2","product":"Adhesion subunit of a-agglutinin of a-cells; C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds","secondary_identifier":"SGD:S000003000","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL032C"}


id: YGL033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04950":null,"YGL033W":null},"has_protein_features":false,"name":"HOP2","ortholog_annotations":[{"gene_uniquename":"YGL033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04950","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein that localizes to chromosomes; prevents synapsis between nonhomologous chromosomes and ensures synapsis between homologs; forms complex with Mnd1p to promote homolog pairing and meiotic double-strand break repair; heterodimer of Hop2p-Mnd1p stimulates the Dmc1p-mediated strand invasion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003001","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL033W"}


id: YGL034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YGL034C is not an essential gene","secondary_identifier":"SGD:S000003002","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL034C"}


id: YGL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03473":null,"SJAG_03911":null,"YGL035C":null},"has_protein_features":false,"name":"MIG1","ortholog_annotations":[{"gene_uniquename":"YGL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03473","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03911","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion; activated in stochastic pulses of nuclear localization, shuttling between cytosol and nucleus depending on external glucose levels and its phosphorylation state","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003003","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL035C"}


id: YGL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VIR1","product":"Protein required for mRNA m6A methylation and meiosis; subunit of the m6A methyltransferase (MIS) complex; required for the stability of MIS complex subunits and consistent with a scaffolding function; non-essential gene required for pre-meiotic S-phase; may be required to initiate the meiotic program, for progression through meiotic divisions and for spore formation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of VIRMA/virilizer/VIR","secondary_identifier":"SGD:S000003004","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL036W"}


id: YGL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04467":null,"YGL037C":null},"has_protein_features":false,"name":"PNC1","ortholog_annotations":[{"gene_uniquename":"YGL037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04467","reference_uniquename":"PMID:29761456"}],"product":"Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; lacks a peroxisomal targeting signal but is imported into peroxisomes via binding to Gpd1p; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003005","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL037C"}


id: YGL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04770":null,"YGL038C":null},"has_protein_features":false,"name":"OCH1","ortholog_annotations":[{"gene_uniquename":"YGL038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04770","reference_uniquename":"PMID:29761456"}],"product":"Mannosyltransferase of the cis-Golgi apparatus; initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003006","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL038C"}


id: YGL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02960":null,"YGL039W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02960","reference_uniquename":"PMID:29761456"}],"product":"Aldehyde reductase; reduces aliphatic aldehyde substrates using NADH as cofactor; shown to reduce carbonyl compounds to chiral alcohols","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003007","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL039W"}


id: YGL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01372":null,"YGL040C":null},"has_protein_features":false,"name":"HEM2","ortholog_annotations":[{"gene_uniquename":"YGL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01372","reference_uniquename":"PMID:29761456"}],"product":"Aminolevulinate dehydratase; a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus; human homolog ALAD can complement yeast hem2 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003008","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL040C"}


id: YGL041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003009","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL041C"}


id: YGL041C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum","secondary_identifier":"SGD:S000028548","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL041C-B"}


id: YGL041W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04722":null,"YGL041W-A":null},"has_protein_features":false,"name":"DPC13","ortholog_annotations":[{"gene_uniquename":"YGL041W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04722","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial protein of unknown function; conserved in fungi; identified by expression profiling and mass spectrometry","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028826","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL041W-A"}


id: YGL042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1","secondary_identifier":"SGD:S000003010","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL042C"}


id: YGL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02691":null,"YGL043W":null},"has_protein_features":false,"name":"DST1","ortholog_annotations":[{"gene_uniquename":"YGL043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02691","reference_uniquename":"PMID:29761456"}],"product":"General transcription elongation factor TFIIS; enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003011","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL043W"}


id: YGL044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01412":null,"SJAG_04022":null,"YGL044C":null},"has_protein_features":false,"name":"RNA15","ortholog_annotations":[{"gene_uniquename":"YGL044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01412","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04022","reference_uniquename":"PMID:29761456"}],"product":"Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003012","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL044C"}


id: YGL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RIM8","product":"Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family","secondary_identifier":"SGD:S000003013","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL045W"}


id: YGL046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YGL046W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YGL045W","secondary_identifier":"SGD:S000003014","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL046W"}


id: YGL047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03311":null,"YGL047W":null},"has_protein_features":false,"name":"ALG13","ortholog_annotations":[{"gene_uniquename":"YGL047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03311","reference_uniquename":"PMID:29761456"}],"product":"Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress; both human homologs ALG13 and ALG14 are required to complement yeast alg13 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003015","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL047W"}


id: YGL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01131":null,"YGL048C":null},"has_protein_features":false,"name":"RPT6","ortholog_annotations":[{"gene_uniquename":"YGL048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01131","reference_uniquename":"PMID:29761456"}],"product":"ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003016","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL048C"}


id: YGL049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01954":null,"YGL049C":null},"has_protein_features":false,"name":"TIF4632","ortholog_annotations":[{"gene_uniquename":"YGL049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01954","reference_uniquename":"PMID:29761456"}],"product":"Translation initiation factor eIF4G and scaffold protein; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E (Cdc33p) and eIF4A (Tif1p/Tif2p); proposed to stimulate the ATPase and helicase activities of eIF4A synergistically with eIF4G based on sequence similarity with Tif4631p; proposed to be required with eIF4E for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; associated with Pab1p-mediated poly(A)-tail stimulated, translation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003017","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL049C"}


id: YGL050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05334":null,"YGL050W":null},"has_protein_features":false,"name":"TYW3","ortholog_annotations":[{"gene_uniquename":"YGL050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05334","reference_uniquename":"PMID:29761456"}],"product":"tRNA methyltransferase required for synthesis of wybutosine; a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003018","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL050W"}


id: YGL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MST27","product":"Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles; MST27 has a paralog, MST28, that arose from a segmental duplication","secondary_identifier":"SGD:S000003019","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL051W"}


id: YGL052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MST27","secondary_identifier":"SGD:S000003020","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL052W"}


id: YGL053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRM8","product":"Pheromone-regulated protein; contains with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family; PRM8 has a paralog, PRM9, that arose from a segmental duplication","secondary_identifier":"SGD:S000003021","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL053W"}


id: YGL054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02264":null,"SJAG_04740":null,"YGL054C":null},"has_protein_features":false,"name":"ERV14","ortholog_annotations":[{"gene_uniquename":"YGL054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02264","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04740","reference_uniquename":"PMID:29761456"}],"product":"COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p and Nha1p antiporter to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003022","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL054C"}


id: YGL055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03943":null,"YGL055W":null},"has_protein_features":false,"name":"OLE1","ortholog_annotations":[{"gene_uniquename":"YGL055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03943","reference_uniquename":"PMID:29761456"}],"product":"Delta(9) fatty acid desaturase; required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003023","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL055W"}


id: YGL056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02380":null,"YGL056C":null},"has_protein_features":false,"name":"SDS23","ortholog_annotations":[{"gene_uniquename":"YGL056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02380","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; SDS23 has a paralog, SDS24, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003024","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL056C"}


id: YGL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GEP7","product":"Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000003025","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL057C"}


id: YGL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00293":null,"YGL058W":null},"has_protein_features":false,"name":"RAD6","ortholog_annotations":[{"gene_uniquename":"YGL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00293","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-conjugating enzyme (E2); involved in postreplication repair as a heterodimer with Rad18p, regulation of K63 polyubiquitination in response to oxidative stress, DSBR and checkpoint control as a heterodimer with Bre1p, ubiquitin-mediated N-end rule protein degradation as a heterodimer with Ubr1p, ERAD with Ubr1p in the absence of canonical ER membrane ligases, and Rpn4p turnover as part of proteasome homeostasis, in complex with Ubr2p and Mub1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003026","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL058W"}


id: YGL059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01402":null,"YGL059W":null},"has_protein_features":false,"name":"PKP2","ortholog_annotations":[{"gene_uniquename":"YGL059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01402","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003027","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL059W"}


id: YGL060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02485":null,"YGL060W":null},"has_protein_features":false,"name":"YBP2","ortholog_annotations":[{"gene_uniquename":"YGL060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02485","reference_uniquename":"PMID:29761456"}],"product":"Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003028","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL060W"}


id: YGL061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01211":null,"YGL061C":null},"has_protein_features":false,"name":"DUO1","ortholog_annotations":[{"gene_uniquename":"YGL061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01211","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Dam1p and Pse1p to connect the DASH complex with microtubules (MT); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003029","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL061C"}


id: YGL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00464":null,"YGL062W":null},"has_protein_features":false,"name":"PYC1","ortholog_annotations":[{"gene_uniquename":"YGL062W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00464","reference_uniquename":"PMID:29761456"}],"product":"Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003030","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL062W"}


id: YGL063C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028633","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL063C-A"}


id: YGL063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00088":null,"SJAG_00319":null,"YGL063W":null},"has_protein_features":false,"name":"PUS2","ortholog_annotations":[{"gene_uniquename":"YGL063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00088","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00319","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification; mutation also affects pseudouridylation of some nuclear-encoded mRNAs; PUS2 has a paralog, PUS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003031","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL063W"}


id: YGL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRH4","product":"Mitochondrial ATP-dependent RNA helicase of the DEAD-box family; required for assembly of the large subunit of mitochondrial ribosomes; binds to the large subunit rRNA, 21S_rRNA; localizes to the matrix face of the mitochondrial inner membrane and associates with the large subunit precursor and with mature ribosomes","secondary_identifier":"SGD:S000003032","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL064C"}


id: YGL065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03056":null,"YGL065C":null},"has_protein_features":false,"name":"ALG2","ortholog_annotations":[{"gene_uniquename":"YGL065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03056","reference_uniquename":"PMID:29761456"}],"product":"Mannosyltransferase in the N-linked glycosylation pathway; catalyzes two consecutive steps in N-linked glycosylation pathway; mutants exhibit temperature-sensitive growth and abnormal accumulation of lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; mutations of human ALG2 cause congenital myasthenic syndrome; human ALG2 complements temperature sensitivity and dolichol-linked oligosaccharide biosynthesis defect of alg2-1 mutant, but mutant form from a patient with CDG-Ii fails to complement","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003033","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL065C"}


id: YGL066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00087":null,"YGL066W":null},"has_protein_features":false,"name":"SGF73","ortholog_annotations":[{"gene_uniquename":"YGL066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00087","reference_uniquename":"PMID:29761456"}],"product":"Subunit of DUBm module of SAGA and SLIK; has roles in anchoring deubiquitination module (DUBm) into SAGA and SLIK complexes, maintaining organization and ubiquitin-binding conformation of Ubp8p, thereby contributing to overall DUBm activity; involved in preinitiation complex assembly at promoters; relocalizes to cytosol under hypoxia; human homolog ATXN7 implicated in spinocerebellar ataxia, and can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003034","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL066W"}


id: YGL067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03091":null,"YGL067W":null},"has_protein_features":false,"name":"NPY1","ortholog_annotations":[{"gene_uniquename":"YGL067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03091","reference_uniquename":"PMID:29761456"}],"product":"NADH diphosphatase (pyrophosphatase); hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; enzymatic component of one of several partly redundant surveillance pathways involved in decapping of non-canonical nicotinamide adenine dinucleotide (NAD) capped nuclear mRNAs (NAD-RNAs); also possesses deCoAping activity involved in the decapping of non-canonical dephospho-CoA capped RNA (dpCoA-RNA); nudix hydrolase family member","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003035","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL067W"}


id: YGL068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05218":null,"YGL068W":null},"has_protein_features":false,"name":"MNP1","ortholog_annotations":[{"gene_uniquename":"YGL068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05218","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L7/L12 and human MRPL7 ribosomal proteins; associates with the mitochondrial nucleoid; required for normal respiratory growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003036","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL068W"}


id: YGL069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance","secondary_identifier":"SGD:S000003037","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL069C"}


id: YGL070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00119":null,"YGL070C":null},"has_protein_features":false,"name":"RPB9","ortholog_annotations":[{"gene_uniquename":"YGL070C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00119","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription; positively regulates ATG1 transcription as a key regulator of autophagy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003038","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL070C"}


id: YGL071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AFT1","product":"Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions localization is regulated by Grx3p, Grx4p, and Fra2p, and promoter binding is negatively regulated via Grx3p-Grx4p binding; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000003039","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL071W"}


id: YGL072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2","secondary_identifier":"SGD:S000003040","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL072C"}


id: YGL073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02472":null,"SJAG_04388":null,"YGL073W":null},"has_protein_features":false,"name":"HSF1","ortholog_annotations":[{"gene_uniquename":"YGL073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02472","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04388","reference_uniquename":"PMID:29761456"}],"product":"Trimeric heat shock transcription factor; forms condensate with Mediator and RNA Pol II upon heat shock; activates multiple genes in response to diverse stresses and transient intracellular acidification; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; monitors translational status through RQC (Ribosomal Quality Control)-mediated translation-stress signal; human homolog HSF1 with linker region mutations can complement yeast hsf1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003041","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL073W"}


id: YGL074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor","secondary_identifier":"SGD:S000003042","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL074C"}


id: YGL075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MPS2","product":"Essential membrane protein localized at nuclear envelope and SPBs; required for insertion of the newly duplicated spindle pole body into the nuclear envelope; potentially phosphorylated by Cdc28p; MPS2 has a paralog, CSM4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003043","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL075C"}


id: YGL076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01551":null,"SJAG_03425":null,"YGL076C":null},"has_protein_features":false,"name":"RPL7A","ortholog_annotations":[{"gene_uniquename":"YGL076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01551","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03425","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L7A; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003044","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL076C"}


id: YGL077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00015":null,"SJAG_00019":null,"SJAG_01096":null,"SJAG_02062":null,"SJAG_02113":null,"SJAG_02133":null,"SJAG_02144":null,"SJAG_02941":null,"SJAG_04135":null,"SJAG_04673":null,"SJAG_06598":null,"YGL077C":null},"has_protein_features":false,"name":"HNM1","ortholog_annotations":[{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00015","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00019","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01096","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02062","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02113","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02133","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02144","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02941","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04135","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04673","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06598","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol; human FLVCR2 (MFSD7c), a choline transporter involved in Fowler syndrome, can complement the yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003045","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL077C"}


id: YGL078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04081":null,"YGL078C":null},"has_protein_features":false,"name":"DBP3","ortholog_annotations":[{"gene_uniquename":"YGL078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04081","reference_uniquename":"PMID:29761456"}],"product":"RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003046","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL078C"}


id: YGL079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"KXD1","product":"Subunit of the BLOC-1 complex involved in endosomal maturation; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome","secondary_identifier":"SGD:S000003047","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL079W"}


id: YGL080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01924":null,"YGL080W":null},"has_protein_features":false,"name":"MPC1","ortholog_annotations":[{"gene_uniquename":"YGL080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01924","reference_uniquename":"PMID:29761456"}],"product":"Highly conserved subunit of mitochondrial pyruvate carrier (MPC); MPC is a mitochondrial inner membrane complex that mediates pyruvate uptake and comprises Mpc1p and Mpc2p during fermentative growth, or Mcp1p and Mpc3p during respiratory growth; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog MPC1 is associated with lactic acidosis and hyperpyruvatemia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003048","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL080W"}


id: YGL081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis","secondary_identifier":"SGD:S000003049","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL081W"}


id: YGL082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01481":null,"YGL082W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGL082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01481","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; MINDY family deubiquitinase that does not appear to contain catalytic activity; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; not an essential gene; YGL082W has a paralog, YPL191C, that arose from the whole genome duplication; ortholog of human MINDY1/FAM63A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003050","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL082W"}


id: YGL083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00875":null,"YGL083W":null},"has_protein_features":false,"name":"SCY1","ortholog_annotations":[{"gene_uniquename":"YGL083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00875","reference_uniquename":"PMID:29761456"}],"product":"Putative kinase; suppressor of GTPase mutant; dosage-sensitive modulator of mitochondrial DNA (mtDNA) homeostasis; localizes to the mitochondrial matrix, and to the cytosol and clathrin-coated vesicles in HTP studies; similar to bovine rhodopsin kinase; may have a role in intracellular sterol transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003051","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL083W"}


id: YGL084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04337":null,"YGL084C":null},"has_protein_features":false,"name":"GUP1","ortholog_annotations":[{"gene_uniquename":"YGL084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04337","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; role in misfolded protein quality control; proposed to be involved in glycerol transport; homolog of the mammalian Hedgehog pathway modulator HHATL; GUP1 has a paralog, GUP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003052","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL084C"}


id: YGL085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01749":null,"YGL085W":null},"has_protein_features":false,"name":"LCL3","ortholog_annotations":[{"gene_uniquename":"YGL085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01749","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003053","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL085W"}


id: YGL086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04884":null,"YGL086W":null},"has_protein_features":false,"name":"MAD1","ortholog_annotations":[{"gene_uniquename":"YGL086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04884","reference_uniquename":"PMID:29761456"}],"product":"Coiled-coil protein involved in spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of anaphase promoting complex activity; forms a complex with Mad2p; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003054","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL086W"}


id: YGL087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02918":null,"YGL087C":null},"has_protein_features":false,"name":"MMS2","ortholog_annotations":[{"gene_uniquename":"YGL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02918","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003055","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL087C"}


id: YGL088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; partially overlaps snR10, a snoRNA required for preRNA processing","secondary_identifier":"SGD:S000003056","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL088W"}


id: YGL089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MF(ALPHA)2","product":"Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed; binds copper(II) ions","secondary_identifier":"SGD:S000003057","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL089C"}


id: YGL090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02237":null,"YGL090W":null},"has_protein_features":false,"name":"LIF1","ortholog_annotations":[{"gene_uniquename":"YGL090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02237","reference_uniquename":"PMID:29761456"}],"product":"Component of the DNA ligase IV complex; this complex mediates nonhomologous end joining in DNA double-strand break repair; sumoylated by Siz1p and Nfi1p SUMO ligases on Lys301; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003058","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL090W"}


id: YGL091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02994":null,"YGL091C":null},"has_protein_features":false,"name":"NBP35","ortholog_annotations":[{"gene_uniquename":"YGL091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02994","reference_uniquename":"PMID:29761456"}],"product":"Essential cytoplasmic iron-sulfur cluster binding protein; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003059","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL091C"}


id: YGL092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03299":null,"YGL092W":null},"has_protein_features":false,"name":"NUP145","ortholog_annotations":[{"gene_uniquename":"YGL092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03299","reference_uniquename":"PMID:29761456"}],"product":"Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003060","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL092W"}


id: YGL093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04259":null,"YGL093W":null},"has_protein_features":false,"name":"SPC105","ortholog_annotations":[{"gene_uniquename":"YGL093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04259","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Kre28p; modified by sumoylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003061","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL093W"}


id: YGL094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00966":null,"YGL094C":null},"has_protein_features":false,"name":"PAN2","ortholog_annotations":[{"gene_uniquename":"YGL094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00966","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; complex acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003062","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL094C"}


id: YGL095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03889":null,"YGL095C":null},"has_protein_features":false,"name":"VPS45","ortholog_annotations":[{"gene_uniquename":"YGL095C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03889","reference_uniquename":"PMID:29761456"}],"product":"Protein of the Sec1p/Munc-18 family; essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment; mutation in human VPS45 is associated with congenital neutropenia and primary myelofibrosis of infancy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003063","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL095C"}


id: YGL096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TOS8","product":"Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003064","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL096W"}


id: YGL097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04464":null,"YGL097W":null},"has_protein_features":false,"name":"SRM1","ortholog_annotations":[{"gene_uniquename":"YGL097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04464","reference_uniquename":"PMID:29761456"}],"product":"Nucleotide exchange factor for Gsp1p; localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p; human homolog of the RAN GEF, RCC1, can complement a temperature sensitive point mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003065","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL097W"}


id: YGL098W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02586":null,"YGL098W":null},"has_protein_features":false,"name":"USE1","ortholog_annotations":[{"gene_uniquename":"YGL098W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02586","reference_uniquename":"PMID:29761456"}],"product":"Essential SNARE protein localized to the ER; involved in retrograde traffic from the Golgi to the ER and Sey1p-independent homotypic ER fusion; required for efficient nuclear fusion during mating; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003066","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL098W"}


id: YGL099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01339":null,"YGL099W":null},"has_protein_features":false,"name":"LSG1","ortholog_annotations":[{"gene_uniquename":"YGL099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01339","reference_uniquename":"PMID:29761456"}],"product":"Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003067","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL099W"}


id: YGL100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02424":null,"YGL100W":null},"has_protein_features":false,"name":"SEH1","ortholog_annotations":[{"gene_uniquename":"YGL100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02424","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Nup84 nuclear pore and SEACAT subcomplexes; involved in nucleocytoplasmic transport and NPC biogenesis in the nuclear pore subcomplex; subunit of SEACAT, a subcomplex of the SEA complex that inhibits the TORC1 inhibitory role of SEACIT (Iml1p-Npr2p-Npr3p), a GAP for Gtr1p in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; human SEH1 homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003068","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL100W"}


id: YGL101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01055":null,"YGL101W":null},"has_protein_features":false,"name":"YGK1","ortholog_annotations":[{"gene_uniquename":"YGL101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01055","reference_uniquename":"PMID:29761456"}],"product":"5'-deoxynucleotidase; non-essential gene involved in deoxyribonucleoside monophosphate degradation; interacts with the DNA helicase Hpr5p; YGL101W has a paralog, YBR242W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003069","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL101W"}


id: YGL102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein","secondary_identifier":"SGD:S000003070","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL102C"}


id: YGL103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02546":null,"SJAG_03159":null,"YGL103W":null},"has_protein_features":false,"name":"RPL28","ortholog_annotations":[{"gene_uniquename":"YGL103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02546","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03159","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003071","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL103W"}


id: YGL104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VPS73","product":"Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family; VPS73 has a paralog, YBR241C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003072","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL104C"}


id: YGL105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02263":null,"YGL105W":null},"has_protein_features":false,"name":"ARC1","ortholog_annotations":[{"gene_uniquename":"YGL105W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02263","reference_uniquename":"PMID:29761456"}],"product":"Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases; involved in tRNA delivery, stimulating catalysis, and ensuring localization; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress; methionyl-tRNA synthetase is Mes1p; glutamyl-tRNA synthetase is Gus1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003073","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL105W"}


id: YGL106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00228":null,"YGL106W":null},"has_protein_features":false,"name":"MLC1","ortholog_annotations":[{"gene_uniquename":"YGL106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00228","reference_uniquename":"PMID:29761456"}],"product":"Essential light chain for Myo1p; light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003074","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL106W"}


id: YGL107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01446":null,"YGL107C":null},"has_protein_features":false,"name":"RMD9","ortholog_annotations":[{"gene_uniquename":"YGL107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01446","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein that controls mitochondrial gene expression; binds the dodecamer element in mitochondrial mRNAs, facilitates processing and delivery of mitochondrial mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes; RMD9 has a paralog, YBR238C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003075","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL107C"}


id: YGL108C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01656":null,"YGL108C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGL108C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01656","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function, predicted to be palmitoylated; SWAT-GFP, seamless-GFP and mCherry C-terminal fusion proteins localize to the cytosol, while N-terminal GFP fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003076","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL108C"}


id: YGL109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C","secondary_identifier":"SGD:S000003077","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL109W"}


id: YGL110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03189":null,"YGL110C":null},"has_protein_features":false,"name":"CUE3","ortholog_annotations":[{"gene_uniquename":"YGL110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03189","reference_uniquename":"PMID:29761456"}],"product":"Subunit of ribosome-associated quality control trigger complex (RQT); has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003078","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL110C"}


id: YGL111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00271":null,"YGL111W":null},"has_protein_features":false,"name":"NSA1","ortholog_annotations":[{"gene_uniquename":"YGL111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00271","reference_uniquename":"PMID:29761456"}],"product":"Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003079","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL111W"}


id: YGL112C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04274":null,"YGL112C":null},"has_protein_features":false,"name":"TAF6","ortholog_annotations":[{"gene_uniquename":"YGL112C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04274","reference_uniquename":"PMID:29761456"}],"product":"Subunit (60 kDa) of TFIID and SAGA complexes; involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003080","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL112C"}


id: YGL113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04341":null,"YGL113W":null},"has_protein_features":false,"name":"SLD3","ortholog_annotations":[{"gene_uniquename":"YGL113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04341","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with the DDK-phosphorylated MCM complex and required for the recruitment of Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress; homologous to the human Treslin/Ticrr protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003081","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL113W"}


id: YGL114W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters","secondary_identifier":"SGD:S000003082","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL114W"}


id: YGL115W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02785":null,"YGL115W":null},"has_protein_features":false,"name":"SNF4","ortholog_annotations":[{"gene_uniquename":"YGL115W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02785","reference_uniquename":"PMID:29761456"}],"product":"Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003083","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL115W"}


id: YGL116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00666":null,"YGL116W":null},"has_protein_features":false,"name":"CDC20","ortholog_annotations":[{"gene_uniquename":"YGL116W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00666","reference_uniquename":"PMID:29761456"}],"product":"Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003084","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL116W"}


id: YGL117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ARO5","product":"Protein involved in aromatic amino acid biosynthesis; up-regulated following GCN4 induction, amino acid starvation, rapamycin treatment in GCN4-dependent manner; promoter contains Gcn4 control response element, which is bound by Gcn4p in vivo","secondary_identifier":"SGD:S000003085","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL117W"}


id: YGL118C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YGL118C is not an essential gene","secondary_identifier":"SGD:S000003086","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL118C"}


id: YGL119W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00933":null,"YGL119W":null},"has_protein_features":false,"name":"COQ8","ortholog_annotations":[{"gene_uniquename":"YGL119W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00933","reference_uniquename":"PMID:29761456"}],"product":"ATPase required for ubiquinone biosynthesis and respiratory growth; maintains levels of CoQ biosynthetic proteins; binds to CoQ biosynthesis intermediates; UbiB protein kinase-like family member that lacks canonical protein kinase activity; similar to prokaryotic proteins involved in ubiquinone biosynthesis; human homolog ADCK3 complements a coq8 null, is associated with CoQ and respiratory-chain deficiencies, and is mutated in autosomal-recessive cerebellar ataxia type 2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003087","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL119W"}


id: YGL120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00597":null,"YGL120C":null},"has_protein_features":false,"name":"PRP43","ortholog_annotations":[{"gene_uniquename":"YGL120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00597","reference_uniquename":"PMID:29761456"}],"product":"RNA helicase in the DEAH-box family; functions in both RNA polymerase I and polymerase II transcript metabolism; catalyzes removal of U2, U5, and U6 snRNPs from the postsplicing lariat-intron ribonucleoprotein complex; required for efficient biogenesis of both small- and large-subunit rRNAs; acts with Sqs1p to promote 20S to 18S rRNA processing catalyzed by endonuclease Nob1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003088","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL120C"}


id: YGL121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GPG1","product":"Proposed gamma subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing","secondary_identifier":"SGD:S000003089","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL121C"}


id: YGL122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03448":null,"YGL122C":null},"has_protein_features":false,"name":"NAB2","ortholog_annotations":[{"gene_uniquename":"YGL122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03448","reference_uniquename":"PMID:29761456"}],"product":"Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; stimulates RNA polymerase III transcription by enhancing TFIIIB binding to promoters; dimerizes upon RNA binding; protects mRNA against decay by nuclear exosome in a poly(A)-tail-dependent manner; involved in forming export-competent mRNPs in the nucleus; autoregulates mRNA levels; NLS binds Kap104p; protein abundance increases under DNA replication stress; related to human hnRNPs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003090","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL122C"}


id: YGL123C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W","secondary_identifier":"SGD:S000028634","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL123C-A"}


id: YGL123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04475":null,"YGL123W":null},"has_protein_features":false,"name":"RPS2","ortholog_annotations":[{"gene_uniquename":"YGL123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04475","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; required for release of methyltransferase Bud23p from pre-40S precursor; homologous to mammalian ribosomal protein S2 and bacterial S5","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003091","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL123W"}


id: YGL124C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05210":null,"YGL124C":null},"has_protein_features":false,"name":"MON1","ortholog_annotations":[{"gene_uniquename":"YGL124C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05210","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heterodimeric guanine nucleotide exchange factor (GEF); subunit of Mon1-Ccz1 GEF complex which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; role in localizing Ypt7p to vacuolar membrane; required for autophagy, CVT pathway, and mitophagy; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003092","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL124C"}


id: YGL125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03712":null,"YGL125W":null},"has_protein_features":false,"name":"MET13","ortholog_annotations":[{"gene_uniquename":"YGL125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03712","reference_uniquename":"PMID:29761456"}],"product":"Major isozyme of methylenetetrahydrofolate reductase; catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003093","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL125W"}


id: YGL126W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01180":null,"YGL126W":null},"has_protein_features":false,"name":"SCS3","ortholog_annotations":[{"gene_uniquename":"YGL126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01180","reference_uniquename":"PMID:29761456"}],"product":"Protein required for normal ER membrane biosynthesis in response to ER stress; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; human homolog FIT2/FITM2, a fatty acyl-CoA diphosphatase, complements the yeast null mutant; disputed role in the synthesis of inositol phospholipids from inositol; required for inositol prototrophy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003094","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL126W"}


id: YGL127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04647":null,"YGL127C":null},"has_protein_features":false,"name":"SOH1","ortholog_annotations":[{"gene_uniquename":"YGL127C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04647","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003095","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL127C"}


id: YGL128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02560":null,"YGL128C":null},"has_protein_features":false,"name":"CWC23","ortholog_annotations":[{"gene_uniquename":"YGL128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02560","reference_uniquename":"PMID:29761456"}],"product":"Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003096","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL128C"}


id: YGL129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02643":null,"YGL129C":null},"has_protein_features":false,"name":"RSM23","ortholog_annotations":[{"gene_uniquename":"YGL129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02643","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003097","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL129C"}


id: YGL130W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01724":null,"YGL130W":null},"has_protein_features":false,"name":"CEG1","ortholog_annotations":[{"gene_uniquename":"YGL130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01724","reference_uniquename":"PMID:29761456"}],"product":"Guanylyltransferase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of two molecules of Ceg1p and a homodimer of Cet1p, the mRNA 5'-triphosphatase subunit; nuclear import of Ceg1p requires interaction with Cet1p; mammalian capping enzyme is a single bifunctional polypeptide; human homolog RNGTT can complement yeast ceg1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003098","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL130W"}


id: YGL131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03387":null,"YGL131C":null},"has_protein_features":false,"name":"SNT2","ortholog_annotations":[{"gene_uniquename":"YGL131C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03387","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Snt2C complex, RING finger ubiquitin ligase (E3); physically associates with Ecm5p and Rpd3p; along with Ecm5p, recruits Rpd3p to small number of promoters; colocalizes with Ecm5p, independently of Rpd3p, to promoters of stress response genes upon oxidative stress; involved in ubiquitination, degradation of excess histones; interacts with Ubc4p; role in regulating genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003099","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL131C"}


id: YGL132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C","secondary_identifier":"SGD:S000003100","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL132W"}


id: YGL133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ITC1","product":"Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex; required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex; ITC1 has a paralog, YPL216W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003101","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL133W"}


id: YGL134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PCL10","product":"Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate; PCL10 has a paralog, PCL8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003102","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL134W"}


id: YGL135W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02531":null,"SJAG_03122":null,"YGL135W":null},"has_protein_features":false,"name":"RPL1B","ortholog_annotations":[{"gene_uniquename":"YGL135W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02531","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL135W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03122","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal; ribosomes containing Rpl1b are more efficient in translation of respiration-related proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003103","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL135W"}


id: YGL136C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03332":null,"SJAG_03773":null,"YGL136C":null},"has_protein_features":false,"name":"MRM2","ortholog_annotations":[{"gene_uniquename":"YGL136C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03332","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL136C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03773","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial 2' O-ribose methyltransferase; required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003104","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL136C"}


id: YGL137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04070":null,"YGL137W":null},"has_protein_features":false,"name":"SEC27","ortholog_annotations":[{"gene_uniquename":"YGL137W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04070","reference_uniquename":"PMID:29761456"}],"product":"Essential beta'-coat protein of the COPI coatomer; involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003105","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL137W"}


id: YGL138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; has no significant sequence similarity to any known protein","secondary_identifier":"SGD:S000003106","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL138C"}


id: YGL139W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02727":null,"SJAG_04668":null,"YGL139W":null},"has_protein_features":false,"name":"FLC3","ortholog_annotations":[{"gene_uniquename":"YGL139W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02727","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL139W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04668","reference_uniquename":"PMID:29761456"}],"product":"Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER; FLC3 has a paralog, FLC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003107","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL139W"}


id: YGL140C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02011":null,"SJAG_04423":null,"YGL140C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGL140C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02011","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL140C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04423","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003108","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL140C"}


id: YGL141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04429":null,"YGL141W":null},"has_protein_features":false,"name":"HUL5","ortholog_annotations":[{"gene_uniquename":"YGL141W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04429","reference_uniquename":"PMID:29761456"}],"product":"Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD; required for ubiquitination of a subset of cytosolic misfolded proteins upon heat shock","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003109","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL141W"}


id: YGL142C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05327":null,"YGL142C":null},"has_protein_features":false,"name":"GPI10","ortholog_annotations":[{"gene_uniquename":"YGL142C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05327","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein involved in GPI anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the glycosylphosphatidylinositol (GPI) core structure; human PIG-Bp is a functional homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003110","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL142C"}


id: YGL143C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01518":null,"YGL143C":null},"has_protein_features":false,"name":"MRF1","ortholog_annotations":[{"gene_uniquename":"YGL143C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01518","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial translation release factor RF1; involved in stop codon recognition and hydrolysis of peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003111","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL143C"}


id: YGL144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04105":null,"SJAG_04973":null,"YGL144C":null},"has_protein_features":false,"name":"ROG1","ortholog_annotations":[{"gene_uniquename":"YGL144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04105","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGL144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04973","reference_uniquename":"PMID:29761456"}],"product":"Lipase with specificity for monoacylglycerol; preferred substrate is 1-oleoylglycerol; null mutation affects lipid droplet morphology and overexpression causes increased accumulation of reactive oxygen species","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003112","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL144C"}


id: YGL145W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01166":null,"YGL145W":null},"has_protein_features":false,"name":"TIP20","ortholog_annotations":[{"gene_uniquename":"YGL145W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01166","reference_uniquename":"PMID:29761456"}],"product":"Peripheral membrane protein required for COPI vesicle fusion to the ER; mediates Sey1p-independent homotypic ER fusion; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003113","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL145W"}


id: YGL146C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRT6","product":"Integral membrane protein, member of the p24 family; forms complex with Erp3p, Erp5p, and Emp24p; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription","secondary_identifier":"SGD:S000003114","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL146C"}


id: YGL147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00629":null,"SJAG_00748":null,"YGL147C":null},"has_protein_features":false,"name":"RPL9A","ortholog_annotations":[{"gene_uniquename":"YGL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00629","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00748","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L9A; homologous to mammalian ribosomal protein L9 and bacterial L6; RPL9A has a paralog, RPL9B, that arose from a single-locus duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003115","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL147C"}


id: YGL148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03485":null,"YGL148W":null},"has_protein_features":false,"name":"ARO2","ortholog_annotations":[{"gene_uniquename":"YGL148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03485","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003116","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL148W"}


id: YGL149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YGL149W is not an essential gene","secondary_identifier":"SGD:S000003117","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL149W"}


id: YGL150C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02872":null,"YGL150C":null},"has_protein_features":false,"name":"INO80","ortholog_annotations":[{"gene_uniquename":"YGL150C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02872","reference_uniquename":"PMID:29761456"}],"product":"Nucleosome spacing factor; subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity; involved in positioning and spacing of nucleosomes over most genes independently of transcription; promotes nucleosome shifts in the 3' direction; has a role in modulating stress gene transcription","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003118","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL150C"}


id: YGL151W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NUT1","product":"Component of the RNA polymerase II mediator complex; mediator is required for transcriptional activation and also has a role in basal transcription","secondary_identifier":"SGD:S000003119","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL151W"}


id: YGL152C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W","secondary_identifier":"SGD:S000003120","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL152C"}


id: YGL153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00891":null,"YGL153W":null},"has_protein_features":false,"name":"PEX14","ortholog_annotations":[{"gene_uniquename":"YGL153W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00891","reference_uniquename":"PMID:29761456"}],"product":"Central component of the peroxisomal importomer complex; peroxisomal protein import machinery docking complex component; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003121","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL153W"}


id: YGL154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01955":null,"YGL154C":null},"has_protein_features":false,"name":"LYS5","ortholog_annotations":[{"gene_uniquename":"YGL154C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01955","reference_uniquename":"PMID:29761456"}],"product":"Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003122","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL154C"}


id: YGL155W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03029":null,"YGL155W":null},"has_protein_features":false,"name":"CDC43","ortholog_annotations":[{"gene_uniquename":"YGL155W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03029","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of geranylgeranyltransferase type I; subunit of the Ram2p-Cdc43p heterodimer that catalyzes the geranylgeranylation of the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003123","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL155W"}


id: YGL156W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AMS1","product":"Vacuolar alpha mannosidase; involved in free oligosaccharide (fOS) degradation; upregulated under glucose starvation; targeted to vacuole via CVT pathway and AP-3 pathway","secondary_identifier":"SGD:S000003124","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL156W"}


id: YGL157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02960":null,"YGL157W":null},"has_protein_features":false,"name":"ARI1","ortholog_annotations":[{"gene_uniquename":"YGL157W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02960","reference_uniquename":"PMID:29761456"}],"product":"NADPH-dependent aldehyde reductase; utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003125","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL157W"}


id: YGL158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01084":null,"SJAG_01855":null,"YGL158W":null},"has_protein_features":false,"name":"RCK1","ortholog_annotations":[{"gene_uniquename":"YGL158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01084","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01855","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase involved in oxidative stress response; promotes pseudohyphal growth via activation of Ubp3p phosphorylation; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003126","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL158W"}


id: YGL159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04719":null,"YGL159W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGL159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04719","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; deletion mutant has no detectable phenotype","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003127","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL159W"}


id: YGL160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04743":null,"YGL160W":null},"has_protein_features":false,"name":"AIM14","ortholog_annotations":[{"gene_uniquename":"YGL160W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003128","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL160W"}


id: YGL161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00525":null,"YGL161C":null},"has_protein_features":false,"name":"YIP5","ortholog_annotations":[{"gene_uniquename":"YGL161C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00525","reference_uniquename":"PMID:29761456"}],"product":"Protein that interacts with Rab GTPases; localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003129","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL161C"}


id: YGL162W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SUT1","product":"Zn(II)2Cys6 family transcription factor; positively regulates sterol uptake genes under anaerobic conditions; involved in hypoxic gene expression; represses filamentation-inducing genes during vegetative growth; positively regulates mating with SUT2 by repressing expression of genes that act as mating inhibitors; repressed by STE12; relocalizes from the nucleus to the cytoplasm upon DNA replication stress; SUT1 has a paralog, SUT2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003130","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL162W"}


id: YGL163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02460":null,"YGL163C":null},"has_protein_features":false,"name":"RAD54","ortholog_annotations":[{"gene_uniquename":"YGL163C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02460","reference_uniquename":"PMID:29761456"}],"product":"DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family of DNA translocases; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003131","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL163C"}


id: YGL164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00801":null,"SJAG_01695":null,"YGL164C":null},"has_protein_features":false,"name":"YRB30","ortholog_annotations":[{"gene_uniquename":"YGL164C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00801","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL164C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01695","reference_uniquename":"PMID:29761456"}],"product":"RanGTP-binding protein; inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003132","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL164C"}


id: YGL165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W","secondary_identifier":"SGD:S000003133","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL165C"}


id: YGL166W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00802":null,"SJAG_01694":null,"YGL166W":null},"has_protein_features":false,"name":"CUP2","ortholog_annotations":[{"gene_uniquename":"YGL166W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00802","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL166W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01694","reference_uniquename":"PMID:29761456"}],"product":"Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; required for regulation of copper genes in response to DNA-damaging reagents; CUP2 has a paralog, HAA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003134","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL166W"}


id: YGL167C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03850":null,"YGL167C":null},"has_protein_features":false,"name":"PMR1","ortholog_annotations":[{"gene_uniquename":"YGL167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03850","reference_uniquename":"PMID:29761456"}],"product":"High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting, processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; human ATP2C1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003135","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL167C"}


id: YGL168W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HUR1","product":"Protein with a role in DNA repair; mutants show reduced efficiency of non-homologous end-joining repair","secondary_identifier":"SGD:S000003136","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL168W"}


id: YGL169W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04700":null,"YGL169W":null},"has_protein_features":false,"name":"SUA5","ortholog_annotations":[{"gene_uniquename":"YGL169W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04700","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family; binds single-stranded telomeric DNA and null mutant has abnormal telomere length","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003137","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL169W"}


id: YGL170C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPO74","product":"Component of the meiotic outer plaque of the spindle pole body; involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation","secondary_identifier":"SGD:S000003138","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL170C"}


id: YGL171W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00986":null,"YGL171W":null},"has_protein_features":false,"name":"ROK1","ortholog_annotations":[{"gene_uniquename":"YGL171W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00986","reference_uniquename":"PMID:29761456"}],"product":"RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003139","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL171W"}


id: YGL172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00962":null,"YGL172W":null},"has_protein_features":false,"name":"NUP49","ortholog_annotations":[{"gene_uniquename":"YGL172W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00962","reference_uniquename":"PMID:29761456"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003140","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL172W"}


id: YGL173C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03276":null,"YGL173C":null},"has_protein_features":false,"name":"XRN1","ortholog_annotations":[{"gene_uniquename":"YGL173C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03276","reference_uniquename":"PMID:29761456"}],"product":"Evolutionarily-conserved 5'-3' exonuclease; deNADding enzyme that modulates mitochondrial NAD-capped RNA; component of cytoplasmic P-bodies involved in mRNA decay; positively regulates transcription initiation and elongation; involved in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, telomere maintenance, and tRNA intron turnover; negative regulator of autophagy; activated by scavenger decapping enzyme Dcs1p; role in preventing L-A mycovirus pathogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003141","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL173C"}


id: YGL174W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00094":null,"YGL174W":null},"has_protein_features":false,"name":"BUD13","ortholog_annotations":[{"gene_uniquename":"YGL174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00094","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RES complex; RES complex is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern due to a specific defect in MATa1 pre-mRNA splicing which leads to haploid gene expression in diploids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003142","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL174W"}


id: YGL175C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01076":null,"YGL175C":null},"has_protein_features":false,"name":"SAE2","ortholog_annotations":[{"gene_uniquename":"YGL175C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01076","reference_uniquename":"PMID:29761456"}],"product":"Endonuclease required for telomere elongation; required for telomeric 5' C-rich strand resection; involved in ds-break repair and processing hairpin DNA structures with the MRX complex; function requires sumoylation and phosphorylation; exists as inactive oligomers that are transiently released into smaller active units by phosphorylation; DNA damage triggers Sae2p removal, so active Sae2p is present only transiently; sequence and functional similarity with human CtIP/RBBP8","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003143","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL175C"}


id: YGL176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; contributes to high inhibitor stress tolerance; deletion mutant is viable","secondary_identifier":"SGD:S000003144","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL176C"}


id: YGL177W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003145","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL177W"}


id: YGL178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02239":null,"SJAG_05322":null,"YGL178W":null},"has_protein_features":false,"name":"MPT5","ortholog_annotations":[{"gene_uniquename":"YGL178W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02239","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL178W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05322","reference_uniquename":"PMID:29761456"}],"product":"mRNA-binding protein of the PUF family; binds to specific mRNAs, often in the 3' UTR; has broad specificity and binds to more than 1000 mRNAs (16% of the transcriptome); recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003146","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL178W"}


id: YGL179C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03486":null,"YGL179C":null},"has_protein_features":false,"name":"TOS3","ortholog_annotations":[{"gene_uniquename":"YGL179C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03486","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase; related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; localizes to cytosol and peroxisomes; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; TOS3 has a paralog, SAK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003147","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL179C"}


id: YGL180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04232":null,"YGL180W":null},"has_protein_features":false,"name":"ATG1","ortholog_annotations":[{"gene_uniquename":"YGL180W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04232","reference_uniquename":"PMID:29761456"}],"product":"Protein serine/threonine kinase; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; forms a complex with Atg13p and Atg17p during autophagy; required for re-phosphorylation of Atg13p during termination of autophagy, following prolonged nitrogen starvation; essential for cell cycle progression from G2/M to G1 under nitrogen starvation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003148","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL180W"}


id: YGL181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04724":null,"YGL181W":null},"has_protein_features":false,"name":"GTS1","ortholog_annotations":[{"gene_uniquename":"YGL181W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04724","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003149","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL181W"}


id: YGL182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MND1/YGL183C","secondary_identifier":"SGD:S000003150","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL182C"}


id: YGL183C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03751":null,"YGL183C":null},"has_protein_features":false,"name":"MND1","ortholog_annotations":[{"gene_uniquename":"YGL183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03751","reference_uniquename":"PMID:29761456"}],"product":"Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003151","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL183C"}


id: YGL184C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03671":null,"YGL184C":null},"has_protein_features":false,"name":"STR3","ortholog_annotations":[{"gene_uniquename":"YGL184C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03671","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal cystathionine beta-lyase; converts cystathionine into homocysteine; may be redox regulated by Gto1p; involved in the release of the aromatic thiol 3-mercaptohexanol during wine fermentation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003152","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL184C"}


id: YGL185C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein with sequence similar to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000003153","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL185C"}


id: YGL186C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TPN1","product":"Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p","secondary_identifier":"SGD:S000003154","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL186C"}


id: YGL187C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00976":null,"YGL187C":null},"has_protein_features":false,"name":"COX4","ortholog_annotations":[{"gene_uniquename":"YGL187C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00976","reference_uniquename":"PMID:29761456"}],"product":"Subunit IV of cytochrome c oxidase; the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003155","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL187C"}


id: YGL188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003156","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL188C"}


id: YGL188C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028635","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL188C-A"}


id: YGL189C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01366":null,"SJAG_02894":null,"YGL189C":null},"has_protein_features":false,"name":"RPS26A","ortholog_annotations":[{"gene_uniquename":"YGL189C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01366","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL189C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02894","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26A has a paralog, RPS26B, that arose from the whole genome duplication; human homolog can partially complement an RPS26A, RPS26B double null mutant; mutations in the human gene are associated with Diamond-Blackfan anemia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003157","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL189C"}


id: YGL190C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00526":null,"YGL190C":null},"has_protein_features":false,"name":"CDC55","ortholog_annotations":[{"gene_uniquename":"YGL190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00526","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit B of protein phosphatase 2A (PP2A); Zds1p/2p-dependent localization to cytoplasm promotes mitotic entry; localization to nucleus prevents mitotic exit; required for correct nuclear division, chromosome segregation during achiasmate meiosis; maintains nucleolar sequestration of Cdc14p in early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; controls phosphorylation and stability of Cln2p; homolog of mammalian B55","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003158","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL190C"}


id: YGL191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01190":null,"YGL191W":null},"has_protein_features":false,"name":"COX13","ortholog_annotations":[{"gene_uniquename":"YGL191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01190","reference_uniquename":"PMID:29761456"}],"product":"Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003159","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL191W"}


id: YGL192W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IME4","product":"mRNA N6-adenosine methyltransferase; essential for meiosis in S288C but dispensable for meiosis in SK1, mediates N6-adenosine methylation of bulk mRNA during the induction of sporulation which includes the meiotic regulators IME1, IME2 and IME4 itself; repressed in haploids via production of antisense IME4 transcripts; transcribed in diploid cells where antisense transcription is repressed; orthologous to human METTL3 (MT-A70)","secondary_identifier":"SGD:S000003160","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL192W"}


id: YGL193C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Haploid-specific gene repressed by a1-alpha2; turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold","secondary_identifier":"SGD:S000003161","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL193C"}


id: YGL194C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03627":null,"YGL194C":null},"has_protein_features":false,"name":"HOS2","ortholog_annotations":[{"gene_uniquename":"YGL194C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03627","reference_uniquename":"PMID:29761456"}],"product":"Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003162","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL194C"}


id: YGL194C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified based on comparisons of the genome sequences of six Saccharomyces species; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum","secondary_identifier":"SGD:S000087160","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL194C-A"}


id: YGL195W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02026":null,"YGL195W":null},"has_protein_features":false,"name":"GCN1","ortholog_annotations":[{"gene_uniquename":"YGL195W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02026","reference_uniquename":"PMID:29761456"}],"product":"Positive regulator of the Gcn2p kinase activity; forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA; suppresses frameshifting at stalled ribosomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003163","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL195W"}


id: YGL196W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04827":null,"YGL196W":null},"has_protein_features":false,"name":"DSD1","ortholog_annotations":[{"gene_uniquename":"YGL196W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04827","reference_uniquename":"PMID:29761456"}],"product":"D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003164","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL196W"}


id: YGL197W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03623":null,"YGL197W":null},"has_protein_features":false,"name":"MDS3","ortholog_annotations":[{"gene_uniquename":"YGL197W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03623","reference_uniquename":"PMID:29761456"}],"product":"Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain; MDS3 has a paralog, PMD1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003165","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL197W"}


id: YGL198W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01409":null,"YGL198W":null},"has_protein_features":false,"name":"YIP4","ortholog_annotations":[{"gene_uniquename":"YGL198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01409","reference_uniquename":"PMID:29761456"}],"product":"Protein that interacts with Rab GTPases; localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003166","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL198W"}


id: YGL199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W","secondary_identifier":"SGD:S000003167","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL199C"}


id: YGL200C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04196":null,"YGL200C":null},"has_protein_features":false,"name":"EMP24","ortholog_annotations":[{"gene_uniquename":"YGL200C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04196","reference_uniquename":"PMID:29761456"}],"product":"Component of the p24 complex; role in misfolded protein quality control; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003168","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL200C"}


id: YGL201C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00857":null,"YGL201C":null},"has_protein_features":false,"name":"MCM6","ortholog_annotations":[{"gene_uniquename":"YGL201C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00857","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003169","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL201C"}


id: YGL202W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03312":null,"YGL202W":null},"has_protein_features":false,"name":"ARO8","ortholog_annotations":[{"gene_uniquename":"YGL202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03312","reference_uniquename":"PMID:29761456"}],"product":"Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis; involved with Aro9p in production of kynurenic acid to detoxify excess tryptophan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003170","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL202W"}


id: YGL203C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04819":null,"YGL203C":null},"has_protein_features":false,"name":"KEX1","ortholog_annotations":[{"gene_uniquename":"YGL203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04819","reference_uniquename":"PMID:29761456"}],"product":"Cell death protease essential for hypochlorite-induced apoptosis; involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003171","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL203C"}


id: YGL204C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data; protein identified via enrichment-based proteogenomics; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum","secondary_identifier":"SGD:S000003172","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL204C"}


id: YGL205W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"POX1","product":"Fatty-acyl coenzyme A oxidase; involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix; component of a light sensing pathway, converting light into a hydrogen peroxide signal, modulating nucleo-cytoplasmic shuttling of stress-responsive transcription factor, Msn2p","secondary_identifier":"SGD:S000003173","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL205W"}


id: YGL206C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02282":null,"YGL206C":null},"has_protein_features":false,"name":"CHC1","ortholog_annotations":[{"gene_uniquename":"YGL206C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02282","reference_uniquename":"PMID:29761456"}],"product":"Clathrin heavy chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion; the light chain (CLC1) is thought to regulate function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003174","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL206C"}


id: YGL207W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02416":null,"YGL207W":null},"has_protein_features":false,"name":"SPT16","ortholog_annotations":[{"gene_uniquename":"YGL207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02416","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; specifically required for diauxic shift-induced H2B deposition onto rDNA genes; mutations cause reduced nucleosome occupancy over highly transcribed regions; coregulates transcription with Mot1p through preinitiation complex assembly and nucleosome organization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003175","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL207W"}


id: YGL208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03802":null,"YGL208W":null},"has_protein_features":false,"name":"SIP2","ortholog_annotations":[{"gene_uniquename":"YGL208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03802","reference_uniquename":"PMID:29761456"}],"product":"One of three alternate beta subunits of the Snf1 kinase complex; involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane; SIP2 has a paralog, GAL83, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003176","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL208W"}


id: YGL209W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03473":null,"SJAG_03911":null,"YGL209W":null},"has_protein_features":false,"name":"MIG2","ortholog_annotations":[{"gene_uniquename":"YGL209W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03473","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL209W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03911","reference_uniquename":"PMID:29761456"}],"product":"Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced gene repression; under low glucose conditions relocalizes to mitochondrion, where it interacts with Ups1p, antagonizes mitochondrial fission factor Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth in response to glucose depletion; activated in stochastic pulses of nuclear localization in response to low glucose","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003177","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL209W"}


id: YGL210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03915":null,"YGL210W":null},"has_protein_features":false,"name":"YPT32","ortholog_annotations":[{"gene_uniquename":"YGL210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03915","reference_uniquename":"PMID:29761456"}],"product":"Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003178","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL210W"}


id: YGL210W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a protein; YGL210W-A was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YGL211W","secondary_identifier":"SGD:S000028549","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL210W-A"}


id: YGL211W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03932":null,"YGL211W":null},"has_protein_features":false,"name":"NCS6","ortholog_annotations":[{"gene_uniquename":"YGL211W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03932","reference_uniquename":"PMID:29761456"}],"product":"Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs; required for the thiolation of uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae; localizes to cytosol and peroxisomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003179","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL211W"}


id: YGL212W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01324":null,"YGL212W":null},"has_protein_features":false,"name":"VAM7","ortholog_annotations":[{"gene_uniquename":"YGL212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01324","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003180","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL212W"}


id: YGL213C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01218":null,"YGL213C":null},"has_protein_features":false,"name":"SKI8","ortholog_annotations":[{"gene_uniquename":"YGL213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01218","reference_uniquename":"PMID:29761456"}],"product":"Ski complex component and WD-repeat protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003181","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL213C"}


id: YGL214W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C","secondary_identifier":"SGD:S000003182","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL214W"}


id: YGL215W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01716":null,"YGL215W":null},"has_protein_features":false,"name":"CLG1","ortholog_annotations":[{"gene_uniquename":"YGL215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01716","reference_uniquename":"PMID:29761456"}],"product":"Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003183","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL215W"}


id: YGL216W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01297":null,"SJAG_02336":null,"YGL216W":null},"has_protein_features":false,"name":"KIP3","ortholog_annotations":[{"gene_uniquename":"YGL216W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01297","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL216W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02336","reference_uniquename":"PMID:29761456"}],"product":"Kinesin-related antiparallel sliding motor protein; involved in mitotic spindle positioning; sliding activity promotes bipolar spindle assembly and maintenance of genome stability; inhibits spindle elongation, destabilizing late anaphase spindle microtubules that polymerize beyond the midzone","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003184","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL216W"}


id: YGL217C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W","secondary_identifier":"SGD:S000003185","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL217C"}


id: YGL218W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance","secondary_identifier":"SGD:S000003186","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL218W"}


id: YGL219C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01305":null,"YGL219C":null},"has_protein_features":false,"name":"MDM34","ortholog_annotations":[{"gene_uniquename":"YGL219C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01305","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial component of the ERMES complex; links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003187","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL219C"}


id: YGL220W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02474":null,"YGL220W":null},"has_protein_features":false,"name":"BOL2","ortholog_annotations":[{"gene_uniquename":"YGL220W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02474","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic protein involved in repression of iron regulon transcription; forms an iron-independent complex with Fra1p, Grx3p, and Grx4p; null mutant fails to repress the iron regulon and is sensitive to nickel; sequence similarity to human BOLA family member, BOLA2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003188","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL220W"}


id: YGL221C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04563":null,"YGL221C":null},"has_protein_features":false,"name":"NIF3","ortholog_annotations":[{"gene_uniquename":"YGL221C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04563","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003189","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL221C"}


id: YGL222C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01746":null,"YGL222C":null},"has_protein_features":false,"name":"EDC1","ortholog_annotations":[{"gene_uniquename":"YGL222C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01746","reference_uniquename":"PMID:29761456"}],"product":"RNA-binding protein that activates mRNA decapping directly; binds to mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; EDC1 has a paralog, EDC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003190","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL222C"}


id: YGL223C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00041":null,"YGL223C":null},"has_protein_features":false,"name":"COG1","ortholog_annotations":[{"gene_uniquename":"YGL223C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00041","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003191","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL223C"}


id: YGL224C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02593":null,"YGL224C":null},"has_protein_features":false,"name":"SDT1","ortholog_annotations":[{"gene_uniquename":"YGL224C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02593","reference_uniquename":"PMID:29761456"}],"product":"Pyrimidine nucleotidase; responsible for production of nicotinamide riboside and nicotinic acid riboside; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives; SDT1 has a paralog, PHM8, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003192","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL224C"}


id: YGL225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00339":null,"YGL225W":null},"has_protein_features":false,"name":"VRG4","ortholog_annotations":[{"gene_uniquename":"YGL225W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00339","reference_uniquename":"PMID:29761456"}],"product":"Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi; VRG4 has a paralog, HVG1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003193","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL225W"}


id: YGL226C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OST5","product":"Zeta subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins","secondary_identifier":"SGD:S000003194","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL226C-A"}


id: YGL226W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MTC3","product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1","secondary_identifier":"SGD:S000003195","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL226W"}


id: YGL227W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01678":null,"YGL227W":null},"has_protein_features":false,"name":"VID30","ortholog_annotations":[{"gene_uniquename":"YGL227W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01678","reference_uniquename":"PMID:29761456"}],"product":"Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003196","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL227W"}


id: YGL228W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SHE10","product":"Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; putative GPI-anchored protein; overexpression causes growth arrest;; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; SHE10 has a paralog, OSW7/YFR039C, that arose from the whole genome duplication; paralogs are redundant for spore wall dityrosine assembly","secondary_identifier":"SGD:S000003197","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL228W"}


id: YGL229C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04638":null,"YGL229C":null},"has_protein_features":false,"name":"SAP4","ortholog_annotations":[{"gene_uniquename":"YGL229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04638","reference_uniquename":"PMID:29761456"}],"product":"Protein required for function of the Sit4p protein phosphatase; member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p; SAP4 has a paralog, SAP155, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003198","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL229C"}


id: YGL230C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; non-essential gene","secondary_identifier":"SGD:S000003199","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL230C"}


id: YGL231C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02914":null,"YGL231C":null},"has_protein_features":false,"name":"EMC4","ortholog_annotations":[{"gene_uniquename":"YGL231C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02914","reference_uniquename":"PMID:29761456"}],"product":"Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4 and fly CG11137; mutation is functionally complemented by human EMC4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003200","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL231C"}


id: YGL232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01638":null,"YGL232W":null},"has_protein_features":false,"name":"TAN1","ortholog_annotations":[{"gene_uniquename":"YGL232W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01638","reference_uniquename":"PMID:29761456"}],"product":"Adaptor in Kre33p-mediated N4-acetylcytidine modification of tRNAs; tRNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine (ac4C) in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress; contains a conserved THUMP domain, and is homologous to human THUMPD1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003201","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL232W"}


id: YGL233W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03864":null,"YGL233W":null},"has_protein_features":false,"name":"SEC15","ortholog_annotations":[{"gene_uniquename":"YGL233W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03864","reference_uniquename":"PMID:29761456"}],"product":"Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003202","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL233W"}


id: YGL234W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03140":null,"YGL234W":null},"has_protein_features":false,"name":"ADE57","ortholog_annotations":[{"gene_uniquename":"YGL234W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03140","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional enzyme of 'de novo' purine nucleotide pathway; contains both phosphoribosylglycinamidine synthetase/glycinamide ribotide synthetase (EC 6.3.4.13) [\"Ade5\"] and phosphoribosylaminoimidazole synthetase/aminoimidazole ribotide synthetase (EC 6.3.3.1) [\"Ade7\"] activities","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003203","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL234W"}


id: YGL235W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2","secondary_identifier":"SGD:S000003204","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL235W"}


id: YGL236C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04367":null,"YGL236C":null},"has_protein_features":false,"name":"MTO1","ortholog_annotations":[{"gene_uniquename":"YGL236C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04367","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein; forms heterodimer complex with Mss1p that performs 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants; human homolog MTO1 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003205","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL236C"}


id: YGL237C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00698":null,"YGL237C":null},"has_protein_features":false,"name":"HAP2","ortholog_annotations":[{"gene_uniquename":"YGL237C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00698","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding; respiratory defect of the null mutant is functionally complemented by human NFYA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003206","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL237C"}


id: YGL238W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04366":null,"YGL238W":null},"has_protein_features":false,"name":"CSE1","ortholog_annotations":[{"gene_uniquename":"YGL238W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04366","reference_uniquename":"PMID:29761456"}],"product":"Nuclear envelope protein that acts as a recycling factor; mediates the nuclear export of Srp1p (importin alpha) back to the cytoplasm after its import substrates have been released into the nucleoplasm, thereby allowing the participation of Srp1p in multiple rounds of nuclear import; required for accurate chromosome segregation; homolog of metazoan CAS and human CSE1L, overexpression of which is implicated in cancer progression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003207","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL238W"}


id: YGL239C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene CSE1","secondary_identifier":"SGD:S000003208","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL239C"}


id: YGL240W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03561":null,"YGL240W":null},"has_protein_features":false,"name":"DOC1","ortholog_annotations":[{"gene_uniquename":"YGL240W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03561","reference_uniquename":"PMID:29761456"}],"product":"Processivity factor; required for ubiquitination activity of anaphase promoting complex (APC), mediates the activity of APC by contributing to substrate recognition; involved in cyclin proteolysis; contains conserved DOC1 homology domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003209","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL240W"}


id: YGL241W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01789":null,"YGL241W":null},"has_protein_features":false,"name":"KAP114","ortholog_annotations":[{"gene_uniquename":"YGL241W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01789","reference_uniquename":"PMID:29761456"}],"product":"Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003210","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL241W"}


id: YGL242C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02857":null,"YGL242C":null},"has_protein_features":false,"name":"ANK1","ortholog_annotations":[{"gene_uniquename":"YGL242C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02857","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic ankyrin repeat-containing protein; co-purifies with Myo3p and Myo5p by large-scale affinity capture; localization of the long-tailed type I myosins is altered in the null mutant; N-terminally propionylated in vivo; contains three ankyrin repeats and an acidic tail; orthologous to human OSTF1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003211","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL242C"}


id: YGL243W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04380":null,"YGL243W":null},"has_protein_features":false,"name":"TAD1","ortholog_annotations":[{"gene_uniquename":"YGL243W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04380","reference_uniquename":"PMID:29761456"}],"product":"tRNA-specific adenosine deaminase; deaminates adenosine-37 to inosine in tRNA-Ala","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003212","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL243W"}


id: YGL244W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04933":null,"YGL244W":null},"has_protein_features":false,"name":"RTF1","ortholog_annotations":[{"gene_uniquename":"YGL244W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04933","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003213","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL244W"}


id: YGL245W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03277":null,"YGL245W":null},"has_protein_features":false,"name":"GUS1","ortholog_annotations":[{"gene_uniquename":"YGL245W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03277","reference_uniquename":"PMID:29761456"}],"product":"Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003214","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL245W"}


id: YGL246C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02374":null,"YGL246C":null},"has_protein_features":false,"name":"RAI1","ortholog_annotations":[{"gene_uniquename":"YGL246C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02374","reference_uniquename":"PMID:29761456"}],"product":"Nuclear decapping endonuclease; targets mRNAs with unmethylated 7-methylguanosine cap structures and 5'-triphosphates; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; involved in an early step of decapping non-canonical nicotinamide adenine dinucleotide (NAD) capped nuclear mRNAs (NAD-RNAs), part of ncRNA surveillance; relocalizes to the cytosol in response to hypoxia; homologous to human DOM3Z","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003215","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL246C"}


id: YGL247W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01422":null,"YGL247W":null},"has_protein_features":false,"name":"BRR6","ortholog_annotations":[{"gene_uniquename":"YGL247W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01422","reference_uniquename":"PMID:29761456"}],"product":"Essential nuclear envelope integral membrane protein; interacts with chromatin, helping to maintain normal chromatin architecture and transcriptional regulation of certain loci at the nuclear envelope; interacts and functions with Apq12p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA nuclear export, and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; homologous to Brl1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003216","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL247W"}


id: YGL248W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02481":null,"YGL248W":null},"has_protein_features":false,"name":"PDE1","ortholog_annotations":[{"gene_uniquename":"YGL248W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02481","reference_uniquename":"PMID:29761456"}],"product":"Low-affinity cyclic AMP phosphodiesterase; controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003217","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL248W"}


id: YGL249W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ZIP2","product":"Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000003218","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL249W"}


id: YGL250W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02483":null,"YGL250W":null},"has_protein_features":false,"name":"RMR1","ortholog_annotations":[{"gene_uniquename":"YGL250W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02483","reference_uniquename":"PMID:29761456"}],"product":"Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003219","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL250W"}


id: YGL251C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HFM1","product":"Meiosis specific DNA helicase; involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity","secondary_identifier":"SGD:S000003220","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL251C"}


id: YGL252C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RTG2","product":"Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p","secondary_identifier":"SGD:S000003221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL252C"}


id: YGL253W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04334":null,"YGL253W":null},"has_protein_features":false,"name":"HXK2","ortholog_annotations":[{"gene_uniquename":"YGL253W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04334","reference_uniquename":"PMID:29761456"}],"product":"Hexokinase isoenzyme 2; phosphorylates glucose in cytosol; predominant hexokinase during growth on glucose; represses expression of HXK1, GLK1, induces expression of its own gene; antiapoptotic; phosphorylation/dephosphorylation at Ser14 by kinase Snf1p, phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; functions downstream of Sit4p in control of cell cycle, mitochondrial function, oxidative stress resistance, chronological lifespan; has paralog HXK1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003222","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL253W"}


id: YGL254W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FZF1","product":"Transcription factor involved in sulfite metabolism; activates transcription of SSU1, DDI2, DDI3; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL254W"}


id: YGL255W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04185":null,"YGL255W":null},"has_protein_features":false,"name":"ZRT1","ortholog_annotations":[{"gene_uniquename":"YGL255W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04185","reference_uniquename":"PMID:29761456"}],"product":"High-affinity zinc transporter of the plasma membrane; responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL255W"}


id: YGL256W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00240":null,"SJAG_03822":null,"YGL256W":null},"has_protein_features":false,"name":"ADH4","ortholog_annotations":[{"gene_uniquename":"YGL256W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00240","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL256W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03822","reference_uniquename":"PMID:29761456"}],"product":"Alcohol dehydrogenase isoenzyme type IV; dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003225","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL256W"}


id: YGL257C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MNT2","product":"Mannosyltransferase; involved in adding the 4th and 5th mannose residues of O-linked glycans","secondary_identifier":"SGD:S000003226","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL257C"}


id: YGL258W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00161":null,"YGL258W":null},"has_protein_features":false,"name":"VEL1","ortholog_annotations":[{"gene_uniquename":"YGL258W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00161","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has a paralog, YOR387C, that arose from a single-locus duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003227","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL258W"}


id: YGL258W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000007607","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL258W-A"}


id: YGL259W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YPS5","product":"Protein with similarity to GPI-anchored aspartic proteases; such proteases are Yap1p and Yap3p; mCherry fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000003228","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL259W"}


id: YGL260W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium","secondary_identifier":"SGD:S000003229","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL260W"}


id: YGL261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU11","product":"Putative protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2","secondary_identifier":"SGD:S000003230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL261C"}


id: YGL262W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene","secondary_identifier":"SGD:S000003231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL262W"}


id: YGL263W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS12","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000003232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL263W"}


id: YGR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EFM5","product":"S-adenosylmethionine-dependent lysine methyltransferase; involved in the trimethylation of eEF1A (Tef1p/Tef2p) at lysine 79; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in budding yeast; expresses a circular RNA; originally misclassified as a N-6-adenine specific DNA methyltransferase based on sequence similarity; both Efm5p and human ortholog N6AMT2 can methylate eEF1a from either species in vitro","secondary_identifier":"SGD:S000003233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR001C"}


id: YGR002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02385":null,"YGR002C":null},"has_protein_features":false,"name":"SWC4","ortholog_annotations":[{"gene_uniquename":"YGR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02385","reference_uniquename":"PMID:29761456"}],"product":"Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex; associates with and protects nucleosome-free regions of the genome including rDNA, tDNA and telomeric loci, contributing to genome integrity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR002C"}


id: YGR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04335":null,"YGR003W":null},"has_protein_features":false,"name":"CUL3","ortholog_annotations":[{"gene_uniquename":"YGR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04335","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-protein ligase; forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR003W"}


id: YGR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PEX31","product":"Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p; PEX31 has a paralog, PEX30, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR004W"}


id: YGR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04852":null,"YGR005C":null},"has_protein_features":false,"name":"TFG2","ortholog_annotations":[{"gene_uniquename":"YGR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04852","reference_uniquename":"PMID:29761456"}],"product":"TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR005C"}


id: YGR006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02455":null,"YGR006W":null},"has_protein_features":false,"name":"PRP18","ortholog_annotations":[{"gene_uniquename":"YGR006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02455","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor and component of snRNP U5; factor involved in the positioning of the 3' splice site during the second catalytic step of splicing; interacts with Slu7p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR006W"}


id: YGR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04628":null,"YGR007W":null},"has_protein_features":false,"name":"ECT1","ortholog_annotations":[{"gene_uniquename":"YGR007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04628","reference_uniquename":"PMID:29761456"}],"product":"Ethanolamine-phosphate cytidylyltransferase; catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases; inability of the null mutant to synthesize phosphatidylethanolamine and phosphatidylcholine from ethanolamine is functionally complemented by human PCYT2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR007W"}


id: YGR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STF2","product":"Protein involved in resistance to desiccation stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to F0 sector of mitochondrial F1F0 ATPase in vitro and may modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress; STF2 has a paralog, TMA10, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR008C"}


id: YGR009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00826":null,"YGR009C":null},"has_protein_features":false,"name":"SEC9","ortholog_annotations":[{"gene_uniquename":"YGR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00826","reference_uniquename":"PMID:29761456"}],"product":"t-SNARE protein required for secretory vesicle-plasma membrane fusion; similar to but not functionally redundant with Spo20p; interacts non-exocyst bound Sec6p; SNAP-25 homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR009C"}


id: YGR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02889":null,"YGR010W":null},"has_protein_features":false,"name":"NMA2","ortholog_annotations":[{"gene_uniquename":"YGR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02889","reference_uniquename":"PMID:29761456"}],"product":"Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); homolog of human NMNAT; NMA2 has a paralog, NMA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR010W"}


id: YGR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR011W"}


id: YGR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00582":null,"SJAG_01880":null,"YGR012W":null},"has_protein_features":false,"name":"MCY1","ortholog_annotations":[{"gene_uniquename":"YGR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00582","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01880","reference_uniquename":"PMID:29761456"}],"product":"Putative cysteine synthase; localized to the mitochondrial outer membrane; interacts with TCD1 and TCD2, likely forming a complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR012W"}


id: YGR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04163":null,"YGR013W":null},"has_protein_features":false,"name":"SNU71","ortholog_annotations":[{"gene_uniquename":"YGR013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04163","reference_uniquename":"PMID:29761456"}],"product":"Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR013W"}


id: YGR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MSB2","product":"Mucin family member involved in various signaling pathways; functions as osmosensor in the Sho1p-mediated HOG pathway; functions in Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; processed into secreted and cell-associated forms by aspartyl protease Yps1p; potential Cdc28p substrate","secondary_identifier":"SGD:S000003246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR014W"}


id: YGR015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00734":null,"YGR015C":null},"has_protein_features":false,"name":"EAT1","ortholog_annotations":[{"gene_uniquename":"YGR015C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00734","reference_uniquename":"PMID:29761456"}],"product":"Ethanol acetyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR015C"}


id: YGR016C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Endoplasmic reticulum protein of unknown function; deletion confers resistance to fluconazole and to osmotic stress","secondary_identifier":"SGD:S000350096","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR016C-A"}


id: YGR016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06268":null,"YGR016W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06268","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR016W"}


id: YGR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00707":null,"YGR017W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00707","reference_uniquename":"PMID:29761456"}],"product":"Pyridoxamine-phosphate oxidase-related protein (PNPO-RP); deletion causes significant increase in 4.5.6-NADH3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR017W"}


id: YGR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W","secondary_identifier":"SGD:S000003250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR018C"}


id: YGR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03434":null,"YGR019W":null},"has_protein_features":false,"name":"UGA1","ortholog_annotations":[{"gene_uniquename":"YGR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03434","reference_uniquename":"PMID:29761456"}],"product":"Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR019W"}


id: YGR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04015":null,"YGR020C":null},"has_protein_features":false,"name":"VMA7","ortholog_annotations":[{"gene_uniquename":"YGR020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04015","reference_uniquename":"PMID:29761456"}],"product":"Subunit F of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR020C"}


id: YGR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03550":null,"YGR021W":null},"has_protein_features":false,"name":"DPC29","ortholog_annotations":[{"gene_uniquename":"YGR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03550","reference_uniquename":"PMID:29761456"}],"product":"General post-initiation mitochondrial translation factor; peripherally associated with the matrix side of the mitochondrial inner membrane; interacts with mitoribosomal proteins in actively translating cells; human ortholog TACO1 complements the yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR021W"}


id: YGR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W","secondary_identifier":"SGD:S000003254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR022C"}


id: YGR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03969":null,"YGR023W":null},"has_protein_features":false,"name":"MTL1","ortholog_annotations":[{"gene_uniquename":"YGR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03969","reference_uniquename":"PMID:29761456"}],"product":"Transmembrane sensor of the cell wall integrity pathway (CWI); involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; structurally and functionally similar to Mid2p; MTL1 has a paralog, MID2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR023W"}


id: YGR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04233":null,"YGR024C":null},"has_protein_features":false,"name":"THG1","ortholog_annotations":[{"gene_uniquename":"YGR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04233","reference_uniquename":"PMID:29761456"}],"product":"tRNAHis guanylyltransferase; adds a guanosine residue to the 5' end of tRNAH is after transcription and RNase P cleavage; can also catalyze reverse (3'-5') polymerization with certain substrates in a template-dependent reaction; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR024C"}


id: YGR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000003257","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR025W"}


id: YGR026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01460":null,"YGR026W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01460","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003258","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR026W"}


id: YGR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04672":null,"YGR027C":null},"has_protein_features":false,"name":"RPS25A","ortholog_annotations":[{"gene_uniquename":"YGR027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04672","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003259","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR027C"}


id: YGR028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04203":null,"YGR028W":null},"has_protein_features":false,"name":"MSP1","ortholog_annotations":[{"gene_uniquename":"YGR028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04203","reference_uniquename":"PMID:29761456"}],"product":"Highly-conserved N-terminally anchored AAA-ATPase; distributed in the mitochondrial outer membrane and peroxisomes; involved in mitochondrial protein sorting; functions as an extraction engine in local organelle surveillance to remove and initiate degradation of mistargeted proteins, ensuring fidelity of organelle-specific localization of tail-anchored proteins; contains an N-terminal transmembrane domain and C-terminal cytoplasmic ATPase domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003260","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR028W"}


id: YGR029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01647":null,"YGR029W":null},"has_protein_features":false,"name":"ERV1","ortholog_annotations":[{"gene_uniquename":"YGR029W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01647","reference_uniquename":"PMID:29761456"}],"product":"Flavin-linked sulfhydryl oxidase of the mitochondrial IMS; N-terminus is an intrinsically disordered domain that in the cytosol helps target Erv1p to mitochondria, and in the intermembrane space oxidizes Mia40p as part of a disulfide relay system that promotes intermembrane space retention of imported proteins; functional ortholog of human GFER (ALR); human GFER carrying N-terminal 21 amino acids of Erv1p functionally complements the lethality of the erv1 null mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003261","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR029W"}


id: YGR030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01369":null,"SJAG_06613":null,"YGR030C":null},"has_protein_features":false,"name":"POP6","ortholog_annotations":[{"gene_uniquename":"YGR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01369","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06613","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop7p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003262","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR030C"}


id: YGR031C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NAG1","product":"Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; gene is nested within and antisense to IMO32","secondary_identifier":"SGD:S000028636","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR031C-A"}


id: YGR031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00734":null,"YGR031W":null},"has_protein_features":false,"name":"IMO32","ortholog_annotations":[{"gene_uniquename":"YGR031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00734","reference_uniquename":"PMID:29761456"}],"product":"Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003263","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR031W"}


id: YGR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01288":null,"SJAG_02222":null,"SJAG_03587":null,"SJAG_05285":null,"YGR032W":null},"has_protein_features":false,"name":"GSC2","ortholog_annotations":[{"gene_uniquename":"YGR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01288","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02222","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03587","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05285","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of 1,3-beta-glucan synthase; involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; GSC2 has a paralog, FKS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003264","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR032W"}


id: YGR033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01442":null,"YGR033C":null},"has_protein_features":false,"name":"TIM21","ortholog_annotations":[{"gene_uniquename":"YGR033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01442","reference_uniquename":"PMID:29761456"}],"product":"Nonessential component of the TIM23 complex; interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate the Translocase of the Inner Mitochondrial membrane (TIM23 complex) activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003265","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR033C"}


id: YGR034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00921":null,"YGR034W":null},"has_protein_features":false,"name":"RPL26B","ortholog_annotations":[{"gene_uniquename":"YGR034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00921","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003266","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR034W"}


id: YGR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YGR035C has a paralog, YLR346C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003267","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR035C"}


id: YGR035W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028827","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR035W-A"}


id: YGR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02056":null,"YGR036C":null},"has_protein_features":false,"name":"CAX4","ortholog_annotations":[{"gene_uniquename":"YGR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02056","reference_uniquename":"PMID:29761456"}],"product":"Dolichyl pyrophosphate (Dol-P-P) phosphatase; cleaves the anhydride linkage in Dol-P-P; involved in  synthesis of Dol-P-P-linked oligosaccharide intermediate required for protein N-glycosylation; has a luminally oriented active site in the ER; mutation affects vesicular transport, membrane and cell wall biogenesis and lipid homeostasis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003268","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR036C"}


id: YGR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01458":null,"YGR037C":null},"has_protein_features":false,"name":"ACB1","ortholog_annotations":[{"gene_uniquename":"YGR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01458","reference_uniquename":"PMID:29761456"}],"product":"Acyl-CoA-binding protein; transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003269","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR037C"}


id: YGR038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04550":null,"YGR038W":null},"has_protein_features":false,"name":"ORM1","ortholog_annotations":[{"gene_uniquename":"YGR038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04550","reference_uniquename":"PMID:29761456"}],"product":"Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; ORM1 has a paralog, ORM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003270","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR038W"}


id: YGR039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YGR039W is not an essential gene","secondary_identifier":"SGD:S000003271","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR039W"}


id: YGR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02923":null,"YGR040W":null},"has_protein_features":false,"name":"KSS1","ortholog_annotations":[{"gene_uniquename":"YGR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02923","reference_uniquename":"PMID:29761456"}],"product":"Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate Bni4p; the KSS1 gene is nonfunctional in some S288C-related strains and functional in W303a strains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003272","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR040W"}


id: YGR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUD9","product":"Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole; BUD9 has a paralog, BUD8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003273","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR041W"}


id: YGR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02616":null,"YGR042W":null},"has_protein_features":false,"name":"MTE1","ortholog_annotations":[{"gene_uniquename":"YGR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02616","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003274","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR042W"}


id: YGR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04263":null,"YGR043C":null},"has_protein_features":false,"name":"NQM1","ortholog_annotations":[{"gene_uniquename":"YGR043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04263","reference_uniquename":"PMID:29761456"}],"product":"Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; NQM1 has a paralog, TAL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003275","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR043C"}


id: YGR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RME1","product":"Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000003276","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR044C"}


id: YGR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000003277","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR045C"}


id: YGR046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03563":null,"YGR046W":null},"has_protein_features":false,"name":"TAM41","ortholog_annotations":[{"gene_uniquename":"YGR046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03563","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase); required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003278","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR046W"}


id: YGR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01827":null,"YGR047C":null},"has_protein_features":false,"name":"TFC4","ortholog_annotations":[{"gene_uniquename":"YGR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01827","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003279","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR047C"}


id: YGR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04384":null,"YGR048W":null},"has_protein_features":false,"name":"UFD1","ortholog_annotations":[{"gene_uniquename":"YGR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04384","reference_uniquename":"PMID:29761456"}],"product":"Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transcription factors by regulated Ub/proteasome-dependent processing (RUP)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003280","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR048W"}


id: YGR049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SCM4","product":"Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation; SCM4 has a paralog, ATG33, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003281","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR049W"}


id: YGR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data","secondary_identifier":"SGD:S000003282","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR050C"}


id: YGR051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene","secondary_identifier":"SGD:S000003283","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR051C"}


id: YGR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03529":null,"YGR052W":null},"has_protein_features":false,"name":"FMP48","ortholog_annotations":[{"gene_uniquename":"YGR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03529","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000003284","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR052W"}


id: YGR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06256":null,"YGR053C":null},"has_protein_features":false,"name":"MCO32","ortholog_annotations":[{"gene_uniquename":"YGR053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06256","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003285","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR053C"}


id: YGR054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03788":null,"YGR054W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YGR054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03788","reference_uniquename":"PMID:29761456"}],"product":"Eukaryotic initiation factor eIF2A; associates specifically with both 40S subunits and 80S ribosomes, and interacts genetically with both eIF5b and eIF4E; physically interacts with Ssd1p, and associates with mRNAs encoding proteins required for cell wall organization, and some of which require the presence of Ssd1p; translational repressor of cell wall-related proteins; interacts physically and genetically with Xrn1p; homologous to mammalian eIF2A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003286","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR054W"}


id: YGR055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MUP1","product":"High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; involved in both methionine and cysteine uptake; subject to transport-activity dependent, methionine-induced endocytosis, vacuolar delivery and degradation; starvation-induced endocytosis is transport-activity independent","secondary_identifier":"SGD:S000003287","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR055W"}


id: YGR056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03787":null,"YGR056W":null},"has_protein_features":false,"name":"RSC1","ortholog_annotations":[{"gene_uniquename":"YGR056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03787","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook; RSC1 has a paralog, RSC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003288","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR056W"}


id: YGR057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02231":null,"YGR057C":null},"has_protein_features":false,"name":"LST7","ortholog_annotations":[{"gene_uniquename":"YGR057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02231","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino acid stimulation; required for activation of TORC1 in response to amino acid stimulation; recruited to the vacuolar membrane during amino acid starvation and released from the membrane by TORC1; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003289","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR057C"}


id: YGR058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PEF1","product":"Penta-EF-hand protein; required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly","secondary_identifier":"SGD:S000003290","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR058W"}


id: YGR059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPR3","product":"Sporulation-specific homolog of the CDC3/10/11/12 family of genes; septin protein involved in sporulation; regulated by ABFI; the yeast CDC3/10/11/12 family is a family of bud neck microfilament genes","secondary_identifier":"SGD:S000003291","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR059W"}


id: YGR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03018":null,"YGR060W":null},"has_protein_features":false,"name":"ERG25","ortholog_annotations":[{"gene_uniquename":"YGR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03018","reference_uniquename":"PMID:29761456"}],"product":"C-4 methyl sterol oxidase; catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol; human MSMO1 functionally complements the growth defect caused by repression of ERG25 expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003292","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR060W"}


id: YGR061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03355":null,"YGR061C":null},"has_protein_features":false,"name":"ADE6","ortholog_annotations":[{"gene_uniquename":"YGR061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03355","reference_uniquename":"PMID:29761456"}],"product":"Formylglycinamidine-ribonucleotide (FGAM)-synthetase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003293","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR061C"}


id: YGR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05302":null,"YGR062C":null},"has_protein_features":false,"name":"COX18","ortholog_annotations":[{"gene_uniquename":"YGR062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05302","reference_uniquename":"PMID:29761456"}],"product":"Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC; respiratory defect of the null mutant is functionally complemented by human COX18 carrying the N-terminal 54 amino acids of S. cerevisiae Cox18p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003294","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR062C"}


id: YGR063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00483":null,"YGR063C":null},"has_protein_features":false,"name":"SPT4","ortholog_annotations":[{"gene_uniquename":"YGR063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00483","reference_uniquename":"PMID:29761456"}],"product":"Spt4p/5p (DSIF) transcription elongation factor complex subunit; Spt4/5 binds ssRNA in a sequence-specific manner and along with RNAP I and II regulates transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; localizes to kinetochores and heterochromatin, influencing chromosomal dynamics and silencing; required for transcription through long trinucleotide repeats in ORFs and non-protein coding regions; accelerates senescence through rDNA instability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003295","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR063C"}


id: YGR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C","secondary_identifier":"SGD:S000003296","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR064W"}


id: YGR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02779":null,"SJAG_02780":null,"YGR065C":null},"has_protein_features":false,"name":"VHT1","ortholog_annotations":[{"gene_uniquename":"YGR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02779","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02780","reference_uniquename":"PMID:29761456"}],"product":"High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003297","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR065C"}


id: YGR066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03385":null,"YGR066C":null},"has_protein_features":false,"name":"GID10","ortholog_annotations":[{"gene_uniquename":"YGR066C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03385","reference_uniquename":"PMID:29761456"}],"product":"Recognition component (N-recognin) of the Pro/N-degron pathway; recognizes and targets for degradation proteins with N-terminal degradation signals; expressed only under starvation or osmotic stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003298","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR066C"}


id: YGR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p","secondary_identifier":"SGD:S000003299","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR067C"}


id: YGR068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00803":null,"SJAG_01686":null,"YGR068C":null},"has_protein_features":false,"name":"ART5","ortholog_annotations":[{"gene_uniquename":"YGR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00803","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01686","reference_uniquename":"PMID:26896847"}],"product":"Protein proposed to regulate endocytosis of plasma membrane proteins; regulates by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane; SWAT-GFP and mCherry fusion proteins localize to the cytosol","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000003300","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR068C"}


id: YGR068W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with the uncharacterized ORF YGR068C","secondary_identifier":"SGD:S000028637","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR068W-A"}


id: YGR069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003301","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR069W"}


id: YGR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03705":null,"SJAG_04771":null,"YGR070W":null},"has_protein_features":false,"name":"ROM1","ortholog_annotations":[{"gene_uniquename":"YGR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03705","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04771","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP; ROM1 has a paralog, ROM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003302","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR070W"}


id: YGR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ENV11","product":"Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; ENV11 has a paralog, VID22, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003303","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR071C"}


id: YGR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04056":null,"YGR072W":null},"has_protein_features":false,"name":"UPF3","ortholog_annotations":[{"gene_uniquename":"YGR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04056","reference_uniquename":"PMID:29761456"}],"product":"Component of the nonsense-mediated mRNA decay (NMD) pathway; along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003304","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR072W"}


id: YGR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; extensively overlaps essential SMD1 gene encoding a U6 snRNP protein","secondary_identifier":"SGD:S000003305","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR073C"}


id: YGR074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00147":null,"YGR074W":null},"has_protein_features":false,"name":"SMD1","ortholog_annotations":[{"gene_uniquename":"YGR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00147","reference_uniquename":"PMID:29761456"}],"product":"Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; relocalizes to the cytosol in response to hypoxia; homolog of human Sm D1; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003306","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR074W"}


id: YGR075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01308":null,"YGR075C":null},"has_protein_features":false,"name":"PRP38","ortholog_annotations":[{"gene_uniquename":"YGR075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01308","reference_uniquename":"PMID:29761456"}],"product":"Unique component of the U4/U6.U5 tri-snRNP particle; tri-snRNP is required for conformational changes which result in the catalytic activation of the spliceosome; dispensable for spliceosome assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003307","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR075C"}


id: YGR076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02762":null,"YGR076C":null},"has_protein_features":false,"name":"MRPL25","ortholog_annotations":[{"gene_uniquename":"YGR076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02762","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003308","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR076C"}


id: YGR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05315":null,"YGR077C":null},"has_protein_features":false,"name":"PEX8","ortholog_annotations":[{"gene_uniquename":"YGR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05315","reference_uniquename":"PMID:29761456"}],"product":"Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003309","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR077C"}


id: YGR078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00505":null,"YGR078C":null},"has_protein_features":false,"name":"PAC10","ortholog_annotations":[{"gene_uniquename":"YGR078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00505","reference_uniquename":"PMID:29761456"}],"product":"Part of the heteromeric co-chaperone GimC/prefoldin complex; complex promotes efficient protein folding","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003310","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR078C"}


id: YGR079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; YGR079W is not an essential gene","secondary_identifier":"SGD:S000003311","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR079W"}


id: YGR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01993":null,"YGR080W":null},"has_protein_features":false,"name":"TWF1","ortholog_annotations":[{"gene_uniquename":"YGR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01993","reference_uniquename":"PMID:29761456"}],"product":"Twinfilin; highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton; coordinates actin filament severing and monomer sequestering at sites of rapid actin turnover; composed of two cofilin-like regions, stimulates actin depolymerization as does the mouse homolog, mTwf1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003312","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR080W"}


id: YGR081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04339":null,"YGR081C":null},"has_protein_features":false,"name":"SLX9","ortholog_annotations":[{"gene_uniquename":"YGR081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04339","reference_uniquename":"PMID:29761456"}],"product":"Nuclear export receptor for exportin Crm1p; required for pre-rRNA processing and nuclear export of pre-40S pre-ribosomal particles; associates with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; binds G-quadruplex (G4) structures in DNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003313","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR081C"}


id: YGR082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03358":null,"YGR082W":null},"has_protein_features":false,"name":"TOM20","ortholog_annotations":[{"gene_uniquename":"YGR082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03358","reference_uniquename":"PMID:29761456"}],"product":"Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003314","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR082W"}


id: YGR083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02307":null,"YGR083C":null},"has_protein_features":false,"name":"GCD2","ortholog_annotations":[{"gene_uniquename":"YGR083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02307","reference_uniquename":"PMID:29761456"}],"product":"Delta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003315","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR083C"}


id: YGR084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRP13","product":"Mitochondrial ribosomal protein of the small subunit","secondary_identifier":"SGD:S000003316","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR084C"}


id: YGR085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00465":null,"SJAG_02280":null,"YGR085C":null},"has_protein_features":false,"name":"RPL11B","ortholog_annotations":[{"gene_uniquename":"YGR085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00465","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02280","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003317","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR085C"}


id: YGR086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02626":null,"SJAG_02707":null,"YGR086C":null},"has_protein_features":false,"name":"PIL1","ortholog_annotations":[{"gene_uniquename":"YGR086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02626","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02707","reference_uniquename":"PMID:29761456"}],"product":"Eisosome core component involved in endocytosis; mitochondria phosphoprotein that localizes to the outer membrane and is involved in maintaining mitochondrial morphology and mitophagy; phosphorylated (T233) upon Pkc1p hyperactivation in a Slt2p MAPK-dependent fashion; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; BAR domain family member; protein increases in abundance and relocalizes from the plasma membrane to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003318","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR086C"}


id: YGR087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02734":null,"SJAG_03743":null,"SJAG_04842":null,"YGR087C":null},"has_protein_features":false,"name":"PDC6","ortholog_annotations":[{"gene_uniquename":"YGR087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02734","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03743","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04842","reference_uniquename":"PMID:29761456"}],"product":"Minor isoform of pyruvate decarboxylase; decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003319","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR087C"}


id: YGR088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04823":null,"YGR088W":null},"has_protein_features":false,"name":"CTT1","ortholog_annotations":[{"gene_uniquename":"YGR088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04823","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003320","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR088W"}


id: YGR089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NNF2","product":"Protein that exhibits physical and genetic interactions with Rpb8p; Rpb8p is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation","secondary_identifier":"SGD:S000003321","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR089W"}


id: YGR090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03156":null,"YGR090W":null},"has_protein_features":false,"name":"UTP22","ortholog_annotations":[{"gene_uniquename":"YGR090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03156","reference_uniquename":"PMID:29761456"}],"product":"Component of the small-subunit processome; required for nuclear export of tRNAs; forms a complex with Rrp7p; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003322","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR090W"}


id: YGR091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04529":null,"YGR091W":null},"has_protein_features":false,"name":"PRP31","ortholog_annotations":[{"gene_uniquename":"YGR091W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04529","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor; component of the U4/U6-U5 snRNP complex; homologous to human PRPF31 and used to study retinitis pigmentosa","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003323","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR091W"}


id: YGR092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02736":null,"SJAG_04597":null,"YGR092W":null},"has_protein_features":false,"name":"DBF2","ortholog_annotations":[{"gene_uniquename":"YGR092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02736","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04597","reference_uniquename":"PMID:29761456"}],"product":"Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis; DBF2 has a paralog, DBF20, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003324","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR092W"}


id: YGR093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05212":null,"YGR093W":null},"has_protein_features":false,"name":"DRN1","ortholog_annotations":[{"gene_uniquename":"YGR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05212","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor that modulates turnover of branched RNAs by Dbr1p; interacts with spliceosomal components and branched RNA splicing products; enhances Dbr1p debranching in vitro; conserved protein with domain organization identical from yeast to human; N-terminal homology to Dbr1p N-terminus, but Dbr1p catalytic residues not conserved; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003325","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR093W"}


id: YGR094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00443":null,"SJAG_02428":null,"YGR094W":null},"has_protein_features":false,"name":"VAS1","ortholog_annotations":[{"gene_uniquename":"YGR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00443","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02428","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial and cytoplasmic valyl-tRNA synthetase; human homolog VARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003326","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR094W"}


id: YGR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04153":null,"YGR095C":null},"has_protein_features":false,"name":"RRP46","ortholog_annotations":[{"gene_uniquename":"YGR095C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04153","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003327","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR095C"}


id: YGR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00835":null,"YGR096W":null},"has_protein_features":false,"name":"TPC1","ortholog_annotations":[{"gene_uniquename":"YGR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00835","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial membrane transporter; mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003328","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR096W"}


id: YGR097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ASK10","product":"Regulator of the Fps1p glycerol channel; under nonstress conditions, binds to Fps1p to positively regulate glycerol transport; under osmotic stress, multiple phosphorylation by Hog1p causes Ask10p to dissociate from Fps1p; forms homodimers and heterodimerizes with paralog Rgc1p; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; associates with RNA polymerase II holoenzyme","secondary_identifier":"SGD:S000003329","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR097W"}


id: YGR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02542":null,"YGR098C":null},"has_protein_features":false,"name":"ESP1","ortholog_annotations":[{"gene_uniquename":"YGR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02542","reference_uniquename":"PMID:29761456"}],"product":"Separase/separin, a caspase-like cysteine protease; cleaves Mcd1p/Scc1p, a mitotic cohesin complex subunit, resulting in the dissociation of cohesin from chromatin and sister chromatid separation; cleaves meiotic-cohesin subunit Rec8p along chromosome arms in meiosis I and at centromeric sites during meiosis II; inhibits PP2A-Cdc55p to promote mitotic exit; inhibited by Pds1p (securin); relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003330","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR098C"}


id: YGR099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00112":null,"YGR099W":null},"has_protein_features":false,"name":"TEL2","ortholog_annotations":[{"gene_uniquename":"YGR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00112","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003331","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR099W"}


id: YGR100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00864":null,"SJAG_04013":null,"YGR100W":null},"has_protein_features":false,"name":"MDR1","ortholog_annotations":[{"gene_uniquename":"YGR100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00864","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04013","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003332","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR100W"}


id: YGR101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03121":null,"YGR101W":null},"has_protein_features":false,"name":"PCP1","ortholog_annotations":[{"gene_uniquename":"YGR101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03121","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial serine protease; required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003333","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR101W"}


id: YGR102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05560":null,"YGR102C":null},"has_protein_features":false,"name":"GTF1","ortholog_annotations":[{"gene_uniquename":"YGR102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05560","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003334","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR102C"}


id: YGR103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00882":null,"YGR103W":null},"has_protein_features":false,"name":"NOP7","ortholog_annotations":[{"gene_uniquename":"YGR103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00882","reference_uniquename":"PMID:29761456"}],"product":"Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G<sub>0</sub> and the initiation of cell proliferation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003335","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR103W"}


id: YGR104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04820":null,"YGR104C":null},"has_protein_features":false,"name":"SRB5","ortholog_annotations":[{"gene_uniquename":"YGR104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04820","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003336","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR104C"}


id: YGR105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01939":null,"YGR105W":null},"has_protein_features":false,"name":"VMA21","ortholog_annotations":[{"gene_uniquename":"YGR105W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01939","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein required for V-ATPase function; not actual component of vacuolar H+-ATPase (V-ATPase) complex; diverged ortholog of human VMA21/XMEA (X-linked Myopathy with Excessive Autophagy); functions in assembly of V-ATPase; localizes to endoplasmic reticulum (ER)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003337","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR105W"}


id: YGR106C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00771":null,"YGR106C":null},"has_protein_features":false,"name":"VOA1","ortholog_annotations":[{"gene_uniquename":"YGR106C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00771","reference_uniquename":"PMID:29761456"}],"product":"ER protein that functions in assembly of the V0 sector of V-ATPase; functions with other assembly factors; null mutation enhances the vacuolar ATPase (V-ATPase) deficiency of a vma21 mutant impaired in endoplasmic reticulum (ER) retrieval","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003338","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR106C"}


id: YGR107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003339","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR107W"}


id: YGR108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01401":null,"SJAG_04140":null,"YGR108W":null},"has_protein_features":false,"name":"CLB1","ortholog_annotations":[{"gene_uniquename":"YGR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01401","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04140","reference_uniquename":"PMID:29761456"}],"product":"B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB1 has a paralog, CLB2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003340","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR108W"}


id: YGR109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03525":null,"YGR109C":null},"has_protein_features":false,"name":"CLB6","ortholog_annotations":[{"gene_uniquename":"YGR109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03525","reference_uniquename":"PMID:26896847"}],"product":"B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1; CLB6 has a paralog, CLB5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000003341","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR109C"}


id: YGR110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04323":null,"YGR110W":null},"has_protein_features":false,"name":"CLD1","ortholog_annotations":[{"gene_uniquename":"YGR110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04323","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003342","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR110W"}


id: YGR111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","secondary_identifier":"SGD:S000003343","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR111W"}


id: YGR112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03046":null,"YGR112W":null},"has_protein_features":false,"name":"SHY1","ortholog_annotations":[{"gene_uniquename":"YGR112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03046","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein required for complex IV assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome; complex IV is also known as cytochrome c oxidase; also localizes to the peroxisome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003344","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR112W"}


id: YGR113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01224":null,"YGR113W":null},"has_protein_features":false,"name":"DAM1","ortholog_annotations":[{"gene_uniquename":"YGR113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01224","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Duo1p and Pse1p to connect the DASH complex with the microtubules (MT); couples kinetochores to the force produced by MT depolymerization, thereby aiding in chromosome segregation; N-terminal staple region is important for self-assembly of the Dam1 complex higher order ring structure that forms around microtubules; Ipl1p target for regulating kinetochore-MT attachments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003345","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR113W"}


id: YGR114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6","secondary_identifier":"SGD:S000003346","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR114C"}


id: YGR115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C","secondary_identifier":"SGD:S000003347","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR115C"}


id: YGR116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04670":null,"YGR116W":null},"has_protein_features":false,"name":"SPT6","ortholog_annotations":[{"gene_uniquename":"YGR116W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04670","reference_uniquename":"PMID:29761456"}],"product":"Histone chaperone; regulates chromatin structure, transcription, mRNA 3'-end formation and genome stability; role in chromatin remodeling and nucleosome assembly; required for initiation of DNA replication, promoting origin licensing through MCM helicase loading; required for fidelity of promoter selection through maintenance of chromatin structure during transcription; required for H3K36 trimethylation but not dimethylation by Set2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003348","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR116W"}


id: YGR117C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm","secondary_identifier":"SGD:S000003349","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR117C"}


id: YGR118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01632":null,"SJAG_02682":null,"SJAG_03568":null,"YGR118W":null},"has_protein_features":false,"name":"RPS23A","ortholog_annotations":[{"gene_uniquename":"YGR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01632","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02682","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03568","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003350","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR118W"}


id: YGR119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02210":null,"YGR119C":null},"has_protein_features":false,"name":"NUP57","ortholog_annotations":[{"gene_uniquename":"YGR119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02210","reference_uniquename":"PMID:29761456"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003351","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR119C"}


id: YGR120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00578":null,"YGR120C":null},"has_protein_features":false,"name":"COG2","ortholog_annotations":[{"gene_uniquename":"YGR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00578","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; the components of the Golgi complex are Gog1p through Cog8p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003352","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR120C"}


id: YGR121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04136":null,"SJAG_04731":null,"YGR121C":null},"has_protein_features":false,"name":"MEP1","ortholog_annotations":[{"gene_uniquename":"YGR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04136","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YGR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04731","reference_uniquename":"PMID:29761456"}],"product":"Ammonium permease; belongs to Mep-Amt-Rh family of well-conserved ammonium (NH4+) transporters that includes the human Rh factors; expression is under the nitrogen catabolite repression regulation; activity regulated by TORC1 effectors, Npr1p and Par32p; human homolog RHCG complements yeast null mutant; mutations in human homolog RHCG implicated in metabolic acidosis; MEP1 has a paralog, MEP3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003353","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR121C"}


id: YGR121W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028550","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR121W-A"}


id: YGR122C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; similar to YLR334C and YOL106W","secondary_identifier":"SGD:S000007240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR122C-A"}


id: YGR122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress","secondary_identifier":"SGD:S000003354","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR122W"}


id: YGR123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02854":null,"YGR123C":null},"has_protein_features":false,"name":"PPT1","ortholog_annotations":[{"gene_uniquename":"YGR123C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02854","reference_uniquename":"PMID:29761456"}],"product":"Protein serine/threonine phosphatase; regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003355","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR123C"}


id: YGR124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04549":null,"YGR124W":null},"has_protein_features":false,"name":"ASN2","ortholog_annotations":[{"gene_uniquename":"YGR124W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04549","reference_uniquename":"PMID:29761456"}],"product":"Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003356","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR124W"}


id: YGR125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00877":null,"YGR125W":null},"has_protein_features":false,"name":"VSB1","ortholog_annotations":[{"gene_uniquename":"YGR125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00877","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane protein required for uptake and storage of arginine in nitrogen-replete cells; nitrogen starvation appears to inhibit Vsb1-dependent activity, resulting in mobilization of stored vacuolar arginine to the cytosol; arginine uptake appears to be driven by a V-ATPase mediated H+ gradient; member of the APC (amino acid-polyamine-organocation) transporter superfamily","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003357","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR125W"}


id: YGR126W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000003358","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR126W"}


id: YGR127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein involved in heme trafficking to the nucleus; expression is regulated by Msn2p/Msn4p, indicating possible role in stress response; localizes to cytosol and peroxisomes","secondary_identifier":"SGD:S000003359","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR127W"}


id: YGR128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03341":null,"YGR128C":null},"has_protein_features":false,"name":"UTP8","ortholog_annotations":[{"gene_uniquename":"YGR128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03341","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003360","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR128C"}


id: YGR129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02844":null,"YGR129W":null},"has_protein_features":false,"name":"SYF2","ortholog_annotations":[{"gene_uniquename":"YGR129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02844","reference_uniquename":"PMID:29761456"}],"product":"Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; relocalizes to the cytosol in response to hypoxia; isy1 syf2 cells have defective spindles activiating cell cycle arrest","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003361","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR129W"}


id: YGR130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)","secondary_identifier":"SGD:S000003362","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR130C"}


id: YGR131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02338":null,"YGR131W":null},"has_protein_features":false,"name":"FHN1","ortholog_annotations":[{"gene_uniquename":"YGR131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02338","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain; FHN1 has a paralog, NCE102, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003363","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR131W"}


id: YGR132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00079":null,"YGR132C":null},"has_protein_features":false,"name":"PHB1","ortholog_annotations":[{"gene_uniquename":"YGR132C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00079","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003364","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR132C"}


id: YGR133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04857":null,"YGR133W":null},"has_protein_features":false,"name":"PEX4","ortholog_annotations":[{"gene_uniquename":"YGR133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04857","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal ubiquitin conjugating enzyme; required for peroxisomal matrix protein import and peroxisome biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003365","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR133W"}


id: YGR134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CAF130","product":"Subunit of the CCR4-NOT transcriptional regulatory complex; CCR4-NOT complex is evolutionarily-conserved and involved in controlling mRNA initiation, elongation, and degradation","secondary_identifier":"SGD:S000003366","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR134W"}


id: YGR135W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00808":null,"YGR135W":null},"has_protein_features":false,"name":"PRE9","ortholog_annotations":[{"gene_uniquename":"YGR135W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00808","reference_uniquename":"PMID:29761456"}],"product":"Alpha 3 subunit of the 20S proteasome; the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003367","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR135W"}


id: YGR136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04554":null,"YGR136W":null},"has_protein_features":false,"name":"LSB1","ortholog_annotations":[{"gene_uniquename":"YGR136W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04554","reference_uniquename":"PMID:29761456"}],"product":"Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003368","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR136W"}


id: YGR137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003369","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR137W"}


id: YGR138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02344":null,"YGR138C":null},"has_protein_features":false,"name":"TPO2","ortholog_annotations":[{"gene_uniquename":"YGR138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02344","reference_uniquename":"PMID:29761456"}],"product":"Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003370","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR138C"}


id: YGR139W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003371","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR139W"}


id: YGR140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CBF2","product":"Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; sumoylated in an Mms21p-dependent manner; relative distribution to the spindle pole body decreases upon DNA replication stress","secondary_identifier":"SGD:S000003372","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR140W"}


id: YGR141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VPS62","product":"Vacuolar protein sorting (VPS) protein; required for cytoplasm to vacuole targeting of proteins; targeted to vacuole via AP-3 pathway; VPS62 has a paralog, TDA6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003373","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR141W"}


id: YGR142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BTN2","product":"Compartment-specific sequestrase chaperone; small hsp that sequesters proteins at intranuclear quality control sites (INQs); sumoylated form promotes protein clearance from INQs during recovery from genotoxic stress; v-SNARE binding protein that mediates late endosome-Golgi protein sorting; modulates arginine uptake and pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; role in prion curing; expression after severe ethanol stress is involved in clearance of denatured proteins","secondary_identifier":"SGD:S000003374","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR142W"}


id: YGR143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02446":null,"SJAG_02590":null,"SJAG_04690":null,"YGR143W":null},"has_protein_features":false,"name":"SKN1","ortholog_annotations":[{"gene_uniquename":"YGR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02446","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02590","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04690","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in sphingolipid biosynthesis; type II membrane protein; SKN1 has a paralog, KRE6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003375","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR143W"}


id: YGR144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00827":null,"YGR144W":null},"has_protein_features":false,"name":"THI4","ortholog_annotations":[{"gene_uniquename":"YGR144W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00827","reference_uniquename":"PMID:29761456"}],"product":"Thiazole synthase; abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003376","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR144W"}


id: YGR145W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04033":null,"YGR145W":null},"has_protein_features":false,"name":"ENP2","ortholog_annotations":[{"gene_uniquename":"YGR145W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04033","reference_uniquename":"PMID:29761456"}],"product":"Component of the SSU; required for pre-18S rRNA processing, biogenesis of the small ribosomal subunit; interacts with U3 snoRNA, Mpp10p and Bfr2p; contains WD repeats, and has homology to Spb1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003377","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR145W"}


id: YGR146C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03974":null,"YGR146C":null},"has_protein_features":false,"name":"ECL1","ortholog_annotations":[{"gene_uniquename":"YGR146C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03974","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR146C"}


id: YGR146C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR146C-A"}


id: YGR147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07016":null,"YGR147C":null},"has_protein_features":false,"name":"NAT2","ortholog_annotations":[{"gene_uniquename":"YGR147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07016","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; has an apparent role in acetylation of N-terminal methionine residues","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR147C"}


id: YGR148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02243":null,"SJAG_03922":null,"YGR148C":null},"has_protein_features":false,"name":"RPL24B","ortholog_annotations":[{"gene_uniquename":"YGR148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02243","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGR148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03922","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L24B; forms two bridges within ribosome, stimulates translation initiation and elongation; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR148C"}


id: YGR149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03154":null,"YGR149W":null},"has_protein_features":false,"name":"GPC1","ortholog_annotations":[{"gene_uniquename":"YGR149W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03154","reference_uniquename":"PMID:29761456"}],"product":"Glycerophosphocholine acyltransferase (GPCAT); involved in in phosphatidylcholine (PC) synthesis; uses acyl-CoA to acylate glycero-3-phosphocholine to yield lyso-PC; also catalyzes acylation of glycerophosphoethanolamine with acyl-CoA; predicted to be an integral membrane protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR149W"}


id: YGR150C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02217":null,"YGR150C":null},"has_protein_features":false,"name":"CCM1","ortholog_annotations":[{"gene_uniquename":"YGR150C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02217","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial 15S rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; has separable roles in stabilizing mitochondrial 15S rRNA and in maturation of the COB and COX1 mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR150C"}


id: YGR151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000003383","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR151C"}


id: YGR152C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RSR1","product":"Ras-type GTPase; required for bud site selection during both axial and bipolar budding, for morphological changes in response to mating pheromone, and for efficient cell fusion; recruits Cdc24p to the incipient bud site, activating its guanyl-nucleotide exchange factor activity and the Rho-like GTPase, Cdc42p; localizes to the plasma membrane, the incipient bud site, polarized growth sites, the cell division site and the vacuole membrane; Ras superfamily member similar to mammalian Rap GTPases","secondary_identifier":"SGD:S000003384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR152C"}


id: YGR153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000003385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR153W"}


id: YGR154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GTO1","product":"Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization","secondary_identifier":"SGD:S000003386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR154C"}


id: YGR155W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CYS4","product":"Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria; human CBS can complement yeast null mutant","secondary_identifier":"SGD:S000003387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR155W"}


id: YGR156W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PTI1","product":"Essential component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; relocalizes to the cytosol in response to hypoxia; similar to mammalian Cleavage-Stimulation Factor CstF-64","secondary_identifier":"SGD:S000003388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR156W"}


id: YGR157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00825":null,"YGR157W":null},"has_protein_features":false,"name":"CHO2","ortholog_annotations":[{"gene_uniquename":"YGR157W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00825","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylethanolamine methyltransferase (PEMT); catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR157W"}


id: YGR158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00854":null,"YGR158C":null},"has_protein_features":false,"name":"MTR3","ortholog_annotations":[{"gene_uniquename":"YGR158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00854","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR158C"}


id: YGR159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00259":null,"YGR159C":null},"has_protein_features":false,"name":"NSR1","ortholog_annotations":[{"gene_uniquename":"YGR159C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00259","reference_uniquename":"PMID:29761456"}],"product":"Nucleolin, nucleolar protein that binds nuclear localization sequences; required for pre-rRNA processing and ribosome biogenesis; binds to single stranded telomeric DNA and mRNA; binds to G-quadruplex DNA; methylated by Hmt1p; interaction with Top1p and nucleolar localization are negatively regulated by lysine polyphosphorylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR159C"}


id: YGR160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR160W"}


id: YGR161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RTS3","product":"Putative component of the protein phosphatase type 2A complex","secondary_identifier":"SGD:S000003393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR161C"}


id: YGR161W-C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species","secondary_identifier":"SGD:S000029726","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR161W-C"}


id: YGR162W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01954":null,"YGR162W":null},"has_protein_features":false,"name":"TIF4631","ortholog_annotations":[{"gene_uniquename":"YGR162W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01954","reference_uniquename":"PMID:29761456"}],"product":"Translation initiation factor eIF4G and scaffold protein; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E (Cdc33p) and eIF4A (Tif1p/Tif2p); stimulates the ATPase and helicase activities of eIF4A synergistically with eIF4G; required with eIF4E for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; association with Pab1p mediates poly(A) tail-stimulated translation; role in assembly of PET region in biogenesis of 60S ribosomal subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003394","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR162W"}


id: YGR163W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03371":null,"YGR163W":null},"has_protein_features":false,"name":"GTR2","ortholog_annotations":[{"gene_uniquename":"YGR163W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03371","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex; subunit of Gtr1-Gtr2, a GTPase that activates TORC1 in response to amino acid stimulation; negatively regulates the GTPase cycle of Gtr1p, a Ran/TC4 homolog; subunit of EGO, a vacuolar membrane complex that regulates exit from rapamycin-induced growth arrest and esorting of Gap1p; activates transcription when chromatin bound; role in the oxidative stress response; activated by the Lst4p-Lst7p GAP complex; homolog of human RagC","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003395","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR163W"}


id: YGR164W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000003396","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR164W"}


id: YGR165W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02067":null,"YGR165W":null},"has_protein_features":false,"name":"MRPS35","ortholog_annotations":[{"gene_uniquename":"YGR165W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02067","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003397","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR165W"}


id: YGR166W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03663":null,"YGR166W":null},"has_protein_features":false,"name":"TRS65","ortholog_annotations":[{"gene_uniquename":"YGR166W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03663","reference_uniquename":"PMID:29761456"}],"product":"Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; role in cell wall beta-glucan biosynthesis and the stress response","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003398","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR166W"}


id: YGR167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04517":null,"YGR167W":null},"has_protein_features":false,"name":"CLC1","ortholog_annotations":[{"gene_uniquename":"YGR167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04517","reference_uniquename":"PMID:29761456"}],"product":"Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; regulates endocytic progression; thought to regulate clathrin function; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003399","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR167W"}


id: YGR168C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PEX35","product":"Regulator of peroxisome abundance; peroxisomal membrane protein, remote homolog to several curvature-generating human proteins; functionally interacts with vesicle-budding-inducing ADP-ribosylation factor Arf1p","secondary_identifier":"SGD:S000003400","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR168C"}


id: YGR169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PUS6","product":"tRNA:pseudouridine synthase; catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability","secondary_identifier":"SGD:S000003401","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR169C"}


id: YGR169C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03924":null,"YGR169C-A":null},"has_protein_features":false,"name":"LSO2","ortholog_annotations":[{"gene_uniquename":"YGR169C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03924","reference_uniquename":"PMID:29761456"}],"product":"Ribosome-associated protein; required for global translational elongation after recovery from stationary phase due to starvation; crosslinks to the 25S rRNA near the A site that overlaps the GTPase activation center, and to tRNAs; possible role in the iron deprivation response; localizes to the nucleus and cytoplasm, with enhanced nuclear localization under iron-replete conditions; null mutant exhibits slow growth during iron deprivation; orthologous to human CCDC124","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR169C-A"}


id: YGR170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02902":null,"YGR170W":null},"has_protein_features":false,"name":"PSD2","ortholog_annotations":[{"gene_uniquename":"YGR170W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02902","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes; converts phosphatidylserine to phosphatidylethanolamine; controls vacuolar membrane phospholipid content by regulating phospholipids in compartments that will eventually give rise to the vacuole; loss of Psd2p causes a specific reduction in vacuolar membrane PE levels while total PE levels are not significantly affected","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003402","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR170W"}


id: YGR171C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_16456":null,"YGR171C":null},"has_protein_features":false,"name":"MSM1","ortholog_annotations":[{"gene_uniquename":"YGR171C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16456","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial methionyl-tRNA synthetase (MetRS); functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003403","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR171C"}


id: YGR172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03670":null,"YGR172C":null},"has_protein_features":false,"name":"YIP1","ortholog_annotations":[{"gene_uniquename":"YGR172C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03670","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein; required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; human homolog YIPF5 can complement yeast yip1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003404","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGR172C"}


