# genes

id: YLR328W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02889":null,"YLR328W":null},"has_protein_features":false,"name":"NMA1","ortholog_annotations":[{"gene_uniquename":"YLR328W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02889","reference_uniquename":"PMID:29761456"}],"product":"Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; homolog of human NMNAT; NMA1 has a paralog, NMA2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004320","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR328W"}


id: YLR329W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01156":null,"YLR329W":null},"has_protein_features":false,"name":"REC102","ortholog_annotations":[{"gene_uniquename":"YLR329W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01156","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004321","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR329W"}


id: YLR330W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02240":null,"YLR330W":null},"has_protein_features":false,"name":"CHS5","ortholog_annotations":[{"gene_uniquename":"YLR330W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02240","reference_uniquename":"PMID:29761456"}],"product":"Component of the exomer complex; the exomer which also contains Csh6p, Bch1p, Bch2p, and Bud7, is involved in the export of select proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane; interacts selectively with the activated, GTP-bound form of Arf1p; Chs5p is the only protein with a BRCT domain that is not localized to the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004322","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR330W"}


id: YLR331C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"JIP3","product":"Putative protein of unknown function; conserved among S. cerevisiae strains; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2","secondary_identifier":"SGD:S000004323","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR331C"}


id: YLR332W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03969":null,"YLR332W":null},"has_protein_features":false,"name":"MID2","ortholog_annotations":[{"gene_uniquename":"YLR332W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03969","reference_uniquename":"PMID:29761456"}],"product":"O-glycosylated plasma membrane protein; acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p; MID2 has a paralog, MTL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004324","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR332W"}


id: YLR333C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04672":null,"YLR333C":null},"has_protein_features":false,"name":"RPS25B","ortholog_annotations":[{"gene_uniquename":"YLR333C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04672","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25B has a paralog, RPS25A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004325","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR333C"}


id: YLR334C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here","secondary_identifier":"SGD:S000004326","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR334C"}


id: YLR335W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04284":null,"YLR335W":null},"has_protein_features":false,"name":"NUP2","ortholog_annotations":[{"gene_uniquename":"YLR335W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04284","reference_uniquename":"PMID:29761456"}],"product":"Nucleoporin involved in nucleocytoplasmic transport; binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization; involved with Nup60p in nuclear basket remodeling during meiosis; Cdc5p-mediated phosphorylation of Nup60p leads to detachment and reattachment of nuclear basket","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004327","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR335W"}


id: YLR336C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03583":null,"YLR336C":null},"has_protein_features":false,"name":"SGD1","ortholog_annotations":[{"gene_uniquename":"YLR336C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03583","reference_uniquename":"PMID:29761456"}],"product":"Essential nuclear protein; required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004328","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR336C"}


id: YLR337C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03119":null,"YLR337C":null},"has_protein_features":false,"name":"VRP1","ortholog_annotations":[{"gene_uniquename":"YLR337C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03119","reference_uniquename":"PMID:29761456"}],"product":"Verprolin, proline-rich actin-associated protein; involved in cytoskeletal organization and cytokinesis; promotes actin nucleation and endocytosis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004329","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR337C"}


id: YLR338W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OPI9","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C","secondary_identifier":"SGD:S000004330","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR338W"}


id: YLR339C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0","secondary_identifier":"SGD:S000004331","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR339C"}


id: YLR340W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04847":null,"YLR340W":null},"has_protein_features":false,"name":"RPP0","ortholog_annotations":[{"gene_uniquename":"YLR340W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04847","reference_uniquename":"PMID:29761456"}],"product":"Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004332","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR340W"}


id: YLR341W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPO77","product":"Meiosis-specific protein of unknown function; required for spore wall formation during sporulation and for timely prospore membrane closure along with SPS1; required with Sps1p for phosphorylation and turnover of Ssp1p; dispensable for both nuclear divisions during meiosis","secondary_identifier":"SGD:S000004333","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR341W"}


id: YLR342W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01288":null,"SJAG_02222":null,"SJAG_03587":null,"SJAG_05285":null,"YLR342W":null},"has_protein_features":false,"name":"FKS1","ortholog_annotations":[{"gene_uniquename":"YLR342W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01288","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR342W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02222","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR342W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03587","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR342W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05285","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of 1,3-beta-D-glucan synthase; transfers glucose from UDP-glucose to growing chains of glucan via β-1,3-glycosidic linkages, translocating polymerized β-1,3-glucan to the extracellular space; role in cell wall synthesis and maintenance; functionally redundant with alternate catalytic subunit Gsc2p; activity regulated by Rho1p, a subunit of the synthase complex; localizes to sites of cell wall remodeling; contains a cellulose-synthase-like fold; antifungal drug target","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004334","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR342W"}


id: YLR342W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028571","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR342W-A"}


id: YLR343W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01835":null,"YLR343W":null},"has_protein_features":false,"name":"GAS2","ortholog_annotations":[{"gene_uniquename":"YLR343W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01835","reference_uniquename":"PMID:29761456"}],"product":"1,3-beta-glucanosyltransferase; involved with Gas4p in spore wall assembly; has similarity to Gas1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004335","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR343W"}


id: YLR344W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00921":null,"YLR344W":null},"has_protein_features":false,"name":"RPL26A","ortholog_annotations":[{"gene_uniquename":"YLR344W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00921","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004336","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR344W"}


id: YLR345W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00039":null,"YLR345W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR345W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00039","reference_uniquename":"PMID:29761456"}],"product":"Similar to 6-phosphofructo-2-kinase enzymes; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004337","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR345W"}


id: YLR346C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CIS1","product":"Protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; not an essential gene; YLR346C has a paralog, YGR035C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004338","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR346C"}


id: YLR347C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01909":null,"YLR347C":null},"has_protein_features":false,"name":"KAP95","ortholog_annotations":[{"gene_uniquename":"YLR347C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01909","reference_uniquename":"PMID:29761456"}],"product":"Karyopherin beta; forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004339","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR347C"}


id: YLR347W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified ORF KAP95/YLR347C","secondary_identifier":"SGD:S000028681","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR347W-A"}


id: YLR348C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DIC1","product":"Mitochondrial dicarboxylate carrier; integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix","secondary_identifier":"SGD:S000004340","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR348C"}


id: YLR349W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C","secondary_identifier":"SGD:S000004341","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR349W"}


id: YLR350W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04550":null,"YLR350W":null},"has_protein_features":false,"name":"ORM2","ortholog_annotations":[{"gene_uniquename":"YLR350W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04550","reference_uniquename":"PMID:29761456"}],"product":"Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress; ORM2 has a paralog, ORM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004342","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR350W"}


id: YLR351C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02276":null,"YLR351C":null},"has_protein_features":false,"name":"NIT3","ortholog_annotations":[{"gene_uniquename":"YLR351C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02276","reference_uniquename":"PMID:29761456"}],"product":"Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004343","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR351C"}


id: YLR352W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LUG1","product":"Protein of unknown function with similarity to F-box proteins; interacts with the core SCF ubiquitin ligase complex subunits Skp1p and Cdc53p; LUG1 deletion prevents cells containing the [URE3] prion or lacking Ure2p from growing on glycerol","secondary_identifier":"SGD:S000004344","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR352W"}


id: YLR353W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUD8","product":"Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole; BUD8 has a paralog, BUD9, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004345","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR353W"}


id: YLR354C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04263":null,"YLR354C":null},"has_protein_features":false,"name":"TAL1","ortholog_annotations":[{"gene_uniquename":"YLR354C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04263","reference_uniquename":"PMID:29761456"}],"product":"Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate; TAL1 has a paralog, NQM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004346","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR354C"}


id: YLR355C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00396":null,"YLR355C":null},"has_protein_features":false,"name":"ILV5","ortholog_annotations":[{"gene_uniquename":"YLR355C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00396","reference_uniquename":"PMID:29761456"}],"product":"Acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004347","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR355C"}


id: YLR356W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG33","product":"Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes; ATG33 has a paralog, SCM4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004348","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR356W"}


id: YLR357W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03787":null,"YLR357W":null},"has_protein_features":false,"name":"RSC2","ortholog_annotations":[{"gene_uniquename":"YLR357W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03787","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance; RSC2 has a paralog, RSC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004349","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR357W"}


id: YLR358C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W","secondary_identifier":"SGD:S000004350","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR358C"}


id: YLR359W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02850":null,"YLR359W":null},"has_protein_features":false,"name":"ADE13","ortholog_annotations":[{"gene_uniquename":"YLR359W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02850","reference_uniquename":"PMID:29761456"}],"product":"Adenylosuccinate lyase; catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency; human ADSL can complement yeast ADE13 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004351","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR359W"}


id: YLR360W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03403":null,"YLR360W":null},"has_protein_features":false,"name":"VPS38","ortholog_annotations":[{"gene_uniquename":"YLR360W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03403","reference_uniquename":"PMID:29761456"}],"product":"Part of a Vps34p phosphatidylinositol 3-kinase complex; functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004352","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR360W"}


id: YLR361C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04262":null,"YLR361C":null},"has_protein_features":false,"name":"DCR2","ortholog_annotations":[{"gene_uniquename":"YLR361C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04262","reference_uniquename":"PMID:29761456"}],"product":"Protein phosphatase; involved in downregulation of the unfolded protein response (UPR), at least in part through dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START; physically interacts with, dephosphorylates and destabilizes Sic1p; SWAT-GFP and mCherry fusion proteins localize to the vacuole","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004353","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR361C"}


id: YLR361C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028845","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR361C-A"}


id: YLR362W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01718":null,"YLR362W":null},"has_protein_features":false,"name":"STE11","ortholog_annotations":[{"gene_uniquename":"YLR362W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01718","reference_uniquename":"PMID:29761456"}],"product":"Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004354","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR362W"}


id: YLR363C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NMD4","product":"Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","secondary_identifier":"SGD:S000004355","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR363C"}


id: YLR363W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04195":null,"YLR363W-A":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR363W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04195","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007620","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR363W-A"}


id: YLR364C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR366W","secondary_identifier":"SGD:S000028846","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR364C-A"}


id: YLR364W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GRX8","product":"Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic","secondary_identifier":"SGD:S000004356","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR364W"}


id: YLR365W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YLR365W is not an essential gene","secondary_identifier":"SGD:S000004357","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR365W"}


id: YLR366W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A","secondary_identifier":"SGD:S000004358","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR366W"}


id: YLR367W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01512":null,"SJAG_03762":null,"YLR367W":null},"has_protein_features":false,"name":"RPS22B","ortholog_annotations":[{"gene_uniquename":"YLR367W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01512","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR367W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03762","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004359","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR367W"}


id: YLR368W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MDM30","product":"F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains","secondary_identifier":"SGD:S000004360","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR368W"}


id: YLR369W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SSQ1","product":"Mitochondrial hsp70-type molecular chaperone; required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis; involved in maturation of Grx5p and Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia","secondary_identifier":"SGD:S000004361","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR369W"}


id: YLR370C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03086":null,"YLR370C":null},"has_protein_features":false,"name":"ARC18","ortholog_annotations":[{"gene_uniquename":"YLR370C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03086","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004362","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR370C"}


id: YLR371W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03705":null,"SJAG_04771":null,"YLR371W":null},"has_protein_features":false,"name":"ROM2","ortholog_annotations":[{"gene_uniquename":"YLR371W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03705","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR371W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04771","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p; ROM2 has a paralog, ROM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004363","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR371W"}


id: YLR372W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01356":null,"SJAG_02885":null,"YLR372W":null},"has_protein_features":false,"name":"ELO3","ortholog_annotations":[{"gene_uniquename":"YLR372W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01356","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR372W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02885","reference_uniquename":"PMID:29761456"}],"product":"Elongase; involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis; lethality of the elo2 elo3 double null mutation is functionally complemented by human ELOVL1 and weakly complemented by human ELOVL3 or ELOV7","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004364","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR372W"}


id: YLR373C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VID22","product":"G-quadruplex (G4) DNA binding protein; maintains genome integrity by promoting the stability of G4-DNA regions; involved in nucleosome displacement during double-strand break repair; involved in fructose-1,6-bisphosphatase (FBPase) transport from the cytosol to Vid (vacuole import and degradation) vesicles during degradation; glycosylated integral membrane protein of the plasma membrane; localizes to the nucleus; contains a BED-type zinc finger domain and a RNase H-like domain","secondary_identifier":"SGD:S000004365","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR373C"}


id: YLR374C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W","secondary_identifier":"SGD:S000004366","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR374C"}


id: YLR375W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STP3","product":"Zinc-finger protein of unknown function; possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids; STP3 has a paralog, STP4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004367","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR375W"}


id: YLR376C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02181":null,"YLR376C":null},"has_protein_features":false,"name":"PSY3","ortholog_annotations":[{"gene_uniquename":"YLR376C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02181","reference_uniquename":"PMID:29761456"}],"product":"Component of Shu complex (aka PCSS complex); Shu complex also includes Shu1, Csm2, Shu2, and promotes error-free DNA repair; promotes Rad51p filament assembly; Shu complex mediates inhibition of Srs2p function; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004368","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR376C"}


id: YLR377C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FBP1","product":"Fructose-1,6-bisphosphatase; key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; glucose starvation results in redistribution to the periplasm; interacts with Vid30p","secondary_identifier":"SGD:S000004369","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR377C"}


id: YLR378C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02330":null,"YLR378C":null},"has_protein_features":false,"name":"SEC61","ortholog_annotations":[{"gene_uniquename":"YLR378C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02330","reference_uniquename":"PMID:29761456"}],"product":"Conserved ER protein translocation channel; essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms channel for SRP-dependent protein import; with Sec63 complex is required for SRP-independent protein translocation into the ER; involved in posttranslational soluble protein import into the ER, ERAD of soluble substrates, and misfolded soluble protein export from the ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004370","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR378C"}


id: YLR379W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C","secondary_identifier":"SGD:S000004371","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR379W"}


id: YLR379W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Novel ORF identified via pan-genome analysis; conserved in other strains of S. cerevisiae","secondary_identifier":"SGD:S000303812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR379W-A"}


id: YLR380W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01225":null,"SJAG_03172":null,"SJAG_03741":null,"YLR380W":null},"has_protein_features":false,"name":"CSR1","ortholog_annotations":[{"gene_uniquename":"YLR380W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01225","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR380W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03172","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR380W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03741","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004372","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR380W"}


id: YLR381W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00684":null,"YLR381W":null},"has_protein_features":false,"name":"CTF3","ortholog_annotations":[{"gene_uniquename":"YLR381W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00684","reference_uniquename":"PMID:29761456"}],"product":"Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; required for the spindle assembly checkpoint; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004373","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR381W"}


id: YLR382C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04738":null,"YLR382C":null},"has_protein_features":false,"name":"NAM2","ortholog_annotations":[{"gene_uniquename":"YLR382C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04738","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial leucyl-tRNA synthetase; also has direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance; human homolog LARS2 can complement yeast null mutant, and is implicated in Perrault syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004374","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR382C"}


id: YLR383W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02545":null,"YLR383W":null},"has_protein_features":false,"name":"SMC6","ortholog_annotations":[{"gene_uniquename":"YLR383W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02545","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; homologous to S. pombe rad18","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004375","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR383W"}


id: YLR384C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00579":null,"YLR384C":null},"has_protein_features":false,"name":"IKI3","ortholog_annotations":[{"gene_uniquename":"YLR384C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00579","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004376","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR384C"}


id: YLR385C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SWC7","product":"Protein of unknown function; component of the Swr1p complex that incorporates Htz1p into chromatin","secondary_identifier":"SGD:S000004377","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR385C"}


id: YLR386W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01236":null,"YLR386W":null},"has_protein_features":false,"name":"VAC14","ortholog_annotations":[{"gene_uniquename":"YLR386W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01236","reference_uniquename":"PMID:29761456"}],"product":"Enzyme regulator; involved in synthesis of phosphatidylinositol 3,5-bisphosphate, in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; binds negative (Fig4p) and positive (Fab1p) regulators of PtdIns(3,5)P(2) to control endolysosome function; similar to mammalian Vac14p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR386W"}


id: YLR387C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03697":null,"YLR387C":null},"has_protein_features":false,"name":"REH1","ortholog_annotations":[{"gene_uniquename":"YLR387C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03697","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic 60S subunit biogenesis factor; associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR387C"}


id: YLR388W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03254":null,"YLR388W":null},"has_protein_features":false,"name":"RPS29A","ortholog_annotations":[{"gene_uniquename":"YLR388W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03254","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR388W"}


id: YLR389C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01430":null,"YLR389C":null},"has_protein_features":false,"name":"STE23","ortholog_annotations":[{"gene_uniquename":"YLR389C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01430","reference_uniquename":"PMID:29761456"}],"product":"Metalloprotease; involved in N-terminal processing of pro-a-factor to mature form; expressed in both haploids and diploids; one of two yeast homologs of human insulin-degrading enzyme (hIDE); homolog Axl1p is also involved in processing of pro-a-factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR389C"}


id: YLR390W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM19","product":"Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000004382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR390W"}


id: YLR390W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CCW14","product":"Covalently linked cell wall glycoprotein; present in the inner layer of the cell wall","secondary_identifier":"SGD:S000006429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR390W-A"}


id: YLR391W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YLR391W was originally annotated as an independent ORF, but was completely contained in larger ORF YLR391W-A in the same frame, and was merged into it on 7-30-1997","secondary_identifier":"SGD:S000115154","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR391W"}


id: YLR392C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ART10","product":"Protein of unknown function that contains 2 PY motifs; ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene","secondary_identifier":"SGD:S000004384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR392C"}


id: YLR393W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATP10","product":"Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase; mitochondrial inner membrane protein; interacts genetically with ATP6","secondary_identifier":"SGD:S000004385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR393W"}


id: YLR394W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CST9","product":"SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; associates with centromeres early in meiosis, then with chromosome axes and finally with double-strand break sites that are engaged in repair by crossovers; potential Cdc28p substrate","secondary_identifier":"SGD:S000004386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR394W"}


id: YLR395C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COX8","product":"Subunit VIII of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain","secondary_identifier":"SGD:S000004387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR395C"}


id: YLR396C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05194":null,"YLR396C":null},"has_protein_features":false,"name":"VPS33","ortholog_annotations":[{"gene_uniquename":"YLR396C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05194","reference_uniquename":"PMID:29761456"}],"product":"ATP-binding protein that is a subunit of the HOPS and CORVET complexes; essential for protein sorting, vesicle docking, and fusion at the vacuole; binds to SNARE domains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR396C"}


id: YLR397C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00390":null,"YLR397C":null},"has_protein_features":false,"name":"AFG2","ortholog_annotations":[{"gene_uniquename":"YLR397C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00390","reference_uniquename":"PMID:29761456"}],"product":"ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; target of the ribosomal biosynthesis inhibitor diazaborine; may be involved in degradation of aberrant mRNAs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR397C"}


id: YLR398C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04118":null,"YLR398C":null},"has_protein_features":false,"name":"SKI2","ortholog_annotations":[{"gene_uniquename":"YLR398C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04118","reference_uniquename":"PMID:29761456"}],"product":"Ski complex component and putative RNA helicase; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, SKIV2L, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR398C"}


id: YLR399C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02500":null,"SJAG_02701":null,"YLR399C":null},"has_protein_features":false,"name":"BDF1","ortholog_annotations":[{"gene_uniquename":"YLR399C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02500","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR399C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02701","reference_uniquename":"PMID:29761456"}],"product":"BET family transcriptional regulator; associates with TFIID, and is involved in transcription initiation at TATA-containing promoters; essential for meiosis and expression of meiosis-specific genes;  binds acetylated histone H4 at double-strand break (DSB) sites, and promotes end resection, loading of RPA and Rad51p and ds break repair by homologous recombination; contains two bromodomains that correspond to the C-terminal region of mammalian TAF1; partially redundant with paralog Bdf2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR399C"}


id: YLR399W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the characterized ORF BDF1/YLR399C","secondary_identifier":"SGD:S000028682","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR399W-A"}


id: YLR400W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR400W"}


id: YLR401C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03240":null,"YLR401C":null},"has_protein_features":false,"name":"DUS3","ortholog_annotations":[{"gene_uniquename":"YLR401C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03240","reference_uniquename":"PMID:29761456"}],"product":"Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; modifies pre-tRNAs at U47 of the variable arm; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR401C"}


id: YLR402W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004394","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR402W"}


id: YLR403W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03241":null,"YLR403W":null},"has_protein_features":false,"name":"SFP1","ortholog_annotations":[{"gene_uniquename":"YLR403W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03241","reference_uniquename":"PMID:29761456"}],"product":"Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004395","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR403W"}


id: YLR404W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01537":null,"YLR404W":null},"has_protein_features":false,"name":"SEI1","ortholog_annotations":[{"gene_uniquename":"YLR404W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01537","reference_uniquename":"PMID:29761456"}],"product":"Seipin involved in lipid droplet (LD) assembly; controls lipid particle morphology, number, and size; promotes initiation of LD formation on the ER; ensures that LDs bud from the ER towards the cytosolic side of the membrane; forms a complex with Ldb16p at ER-LD contact sites, stabilizing these sites; null mutants have localized accumulation of phosphatidic acid (PA) marker proteins; BSCL2, human homolog implicated in congenital lipodystrophy, complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004396","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR404W"}


id: YLR405W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01041":null,"YLR405W":null},"has_protein_features":false,"name":"DUS4","ortholog_annotations":[{"gene_uniquename":"YLR405W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01041","reference_uniquename":"PMID:29761456"}],"product":"Dihydrouridine synthase; modifies pre-tRNAs at U20a and U20b of the D loop; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004397","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR405W"}


id: YLR406C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01676":null,"SJAG_02755":null,"YLR406C":null},"has_protein_features":false,"name":"RPL31B","ortholog_annotations":[{"gene_uniquename":"YLR406C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01676","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR406C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02755","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004398","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR406C"}


id: YLR406C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole","secondary_identifier":"SGD:S000028683","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR406C-A"}


id: YLR407W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00347":null,"YLR407W":null},"has_protein_features":false,"name":"GAG1","ortholog_annotations":[{"gene_uniquename":"YLR407W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00347","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus; Interacts with CKA2 in a potentially competitive mode with the CK2 holoenzyme. Structural prediction analysis reveals a clamp-domain (rear, hinge, front), an unstructured gag region, and a lock-domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004399","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR407W"}


id: YLR408C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BLS1","product":"Subunit of the BLOC-1 complex involved in endosomal maturation; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene","secondary_identifier":"SGD:S000004400","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR408C"}


id: YLR409C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00245":null,"YLR409C":null},"has_protein_features":false,"name":"UTP21","ortholog_annotations":[{"gene_uniquename":"YLR409C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00245","reference_uniquename":"PMID:29761456"}],"product":"Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma; Small Subunit processome is also known as SSU processome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004401","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR409C"}


id: YLR410W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00244":null,"YLR410W":null},"has_protein_features":false,"name":"VIP1","ortholog_annotations":[{"gene_uniquename":"YLR410W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00244","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional inositol pyrophosphate kinase and phosphatase; contains an N-terminal PP-InsP kinase domain that phosphorylates inositol hexakisphosphate and heptakisphosphate, and a C-terminal phosphatase domain that hydrolyzes both 1PP-InsP5 and 5PP-InsP5; IP7 levels decrease during starvation, suggesting a role for PP-InsP enzymes in Pi homeostasis; may regulate the dimorphic switch and the function of the cortical actin cytoskeleton","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004402","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR410W"}


id: YLR411W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01493":null,"SJAG_04246":null,"YLR411W":null},"has_protein_features":false,"name":"CTR3","ortholog_annotations":[{"gene_uniquename":"YLR411W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01493","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR411W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04246","reference_uniquename":"PMID:29761456"}],"product":"High-affinity copper transporter of the plasma membrane; acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004403","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR411W"}


id: YLR412C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028572","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR412C-A"}


id: YLR412W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02069":null,"YLR412W":null},"has_protein_features":false,"name":"BER1","ortholog_annotations":[{"gene_uniquename":"YLR412W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02069","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in microtubule-related processes; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004404","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR412W"}


id: YLR413W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"INA1","product":"Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004405","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR413W"}


id: YLR414C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04620":null,"YLR414C":null},"has_protein_features":false,"name":"PUN1","ortholog_annotations":[{"gene_uniquename":"YLR414C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04620","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004406","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR414C"}


id: YLR415C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YLR415C is not an essential gene","secondary_identifier":"SGD:S000004407","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR415C"}


id: YLR416C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004408","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR416C"}


id: YLR417W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04024":null,"YLR417W":null},"has_protein_features":false,"name":"VPS36","ortholog_annotations":[{"gene_uniquename":"YLR417W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04024","reference_uniquename":"PMID:29761456"}],"product":"Component of ESCRT-II complex; contains GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into endosome; plays role in lager yeast flocculation under brewing conditions; plays role in formation of mutant huntingtin (Htt) aggregates in yeast","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004409","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR417W"}


id: YLR418C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01151":null,"YLR418C":null},"has_protein_features":false,"name":"CDC73","ortholog_annotations":[{"gene_uniquename":"YLR418C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01151","reference_uniquename":"PMID:29761456"}],"product":"Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; role in preventing L-A mycovirus pathogenesis; protein abundance increases in response to DNA replication stress; human homolog, parafibromin, is a tumour suppressor linked to breast, renal and gastric cancers","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004410","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR418C"}


id: YLR419W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02061":null,"SJAG_03533":null,"YLR419W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR419W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02061","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLR419W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03533","reference_uniquename":"PMID:29761456"}],"product":"Predicted RNA helicase of the DEAH-box family; the authentic, non-tagged protein is detected in highly purified mitochondria in HTP studies and sediments with the 40S ribosomal subunit; crosslinks with 18S rRNA; non-essential gene; contains a ubiquitin-associated domain, an RWD domain, a helicase ATP-binding DEAD-like domain, a helicase C terminal domain and a helicase associated domain; does not contain a Rb-like A/B pocket structure; homolog of mammalian translation initiation factor DHX29","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004411","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR419W"}


id: YLR420W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00444":null,"YLR420W":null},"has_protein_features":false,"name":"URA4","ortholog_annotations":[{"gene_uniquename":"YLR420W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00444","reference_uniquename":"PMID:29761456"}],"product":"Dihydroorotase; catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004412","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR420W"}


id: YLR421C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04211":null,"SJAG_04484":null,"YLR421C":null},"has_protein_features":false,"name":"RPN13","ortholog_annotations":[{"gene_uniquename":"YLR421C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04211","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR421C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04484","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004413","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR421C"}


id: YLR422W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DCK1","product":"Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1; upstream component for regulation through the small GTPase Rho5p; may form a complex with Lmo1p that acts as a GEF for Rho5p; interacts with Ino4p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein; DOCK proteins act as guanine nucleotide exchange factors","secondary_identifier":"SGD:S000004414","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR422W"}


id: YLR423C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05017":null,"YLR423C":null},"has_protein_features":false,"name":"ATG17","ortholog_annotations":[{"gene_uniquename":"YLR423C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05017","reference_uniquename":"PMID:29761456"}],"product":"Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004415","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR423C"}


id: YLR424W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03301":null,"YLR424W":null},"has_protein_features":false,"name":"SPP382","ortholog_annotations":[{"gene_uniquename":"YLR424W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03301","reference_uniquename":"PMID:29761456"}],"product":"Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004416","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR424W"}


id: YLR425W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03704":null,"YLR425W":null},"has_protein_features":false,"name":"TUS1","ortholog_annotations":[{"gene_uniquename":"YLR425W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03704","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004417","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR425W"}


id: YLR426W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00593":null,"YLR426W":null},"has_protein_features":false,"name":"TDA5","ortholog_annotations":[{"gene_uniquename":"YLR426W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00593","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004418","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR426W"}


id: YLR427W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02415":null,"YLR427W":null},"has_protein_features":false,"name":"MAG2","ortholog_annotations":[{"gene_uniquename":"YLR427W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02415","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004419","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR427W"}


id: YLR428C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1","secondary_identifier":"SGD:S000004420","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR428C"}


id: YLR429W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00677":null,"YLR429W":null},"has_protein_features":false,"name":"CRN1","ortholog_annotations":[{"gene_uniquename":"YLR429W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00677","reference_uniquename":"PMID:29761456"}],"product":"Coronin; cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR429W"}


id: YLR430W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02242":null,"SJAG_03923":null,"YLR430W":null},"has_protein_features":false,"name":"SEN1","ortholog_annotations":[{"gene_uniquename":"YLR430W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02242","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR430W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03923","reference_uniquename":"PMID:29761456"}],"product":"ATP-dependent 5' to 3' RNA/DNA and DNA helicase; subunit of the exosome-associated Nrd1p complex that mediates 3' end formation of snRNAs, snoRNAs, CUTs and some mRNAs; helicase-independent role in transcription-coupled repair; coordinates replication with transcription, associating with moving forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of juvenile ALS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR430W"}


id: YLR431C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG23","product":"Peripheral membrane protein required for autophagy and CVT; required for cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p","secondary_identifier":"SGD:S000004423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR431C"}


id: YLR432W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01298":null,"YLR432W":null},"has_protein_features":false,"name":"IMD3","ortholog_annotations":[{"gene_uniquename":"YLR432W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01298","reference_uniquename":"PMID:29761456"}],"product":"Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD3 has a paralog, IMD4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004424","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR432W"}


id: YLR433C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03631":null,"YLR433C":null},"has_protein_features":false,"name":"CNA1","ortholog_annotations":[{"gene_uniquename":"YLR433C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03631","reference_uniquename":"PMID:29761456"}],"product":"Calcineurin A; one isoform (the other is Cmp2p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CNA1 has a paralog, CMP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR433C"}


id: YLR434C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W","secondary_identifier":"SGD:S000004426","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR434C"}


id: YLR435W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02358":null,"YLR435W":null},"has_protein_features":false,"name":"TSR2","ortholog_annotations":[{"gene_uniquename":"YLR435W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02358","reference_uniquename":"PMID:29761456"}],"product":"Protein with a potential role in pre-rRNA processing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004427","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR435W"}


id: YLR436C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00567":null,"SJAG_03278":null,"SJAG_03634":null,"YLR436C":null},"has_protein_features":false,"name":"ECM30","ortholog_annotations":[{"gene_uniquename":"YLR436C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00567","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR436C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03278","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR436C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03634","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004428","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR436C"}


id: YLR437C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01348":null,"SJAG_02874":null,"YLR437C":null},"has_protein_features":false,"name":"DIF1","ortholog_annotations":[{"gene_uniquename":"YLR437C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01348","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR437C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02874","reference_uniquename":"PMID:29761456"}],"product":"Protein that regulates nuclear import of Rnr2p and Rnr4p; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half shows similarity to S. pombe Spd1 protein; DIF1 has a paralog, SML1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR437C"}


id: YLR437C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W","secondary_identifier":"SGD:S000028684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR437C-A"}


id: YLR438C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03460":null,"YLR438C-A":null},"has_protein_features":false,"name":"LSM3","ortholog_annotations":[{"gene_uniquename":"YLR438C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03460","reference_uniquename":"PMID:29761456"}],"product":"Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR438C-A"}


id: YLR438W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00495":null,"YLR438W":null},"has_protein_features":false,"name":"CAR2","ortholog_annotations":[{"gene_uniquename":"YLR438W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00495","reference_uniquename":"PMID:29761456"}],"product":"L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004430","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR438W"}


id: YLR439W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01045":null,"YLR439W":null},"has_protein_features":false,"name":"MRPL4","ortholog_annotations":[{"gene_uniquename":"YLR439W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01045","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR439W"}


id: YLR440C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04956":null,"YLR440C":null},"has_protein_features":false,"name":"SEC39","ortholog_annotations":[{"gene_uniquename":"YLR440C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04956","reference_uniquename":"PMID:29761456"}],"product":"Component of the Dsl1p tethering complex; this complex interacts with ER SNAREs Sec20p and Use1p; mediates Sey1p-independent homotypic ER fusion; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004432","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR440C"}


id: YLR441C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00733":null,"SJAG_02522":null,"YLR441C":null},"has_protein_features":false,"name":"RPS1A","ortholog_annotations":[{"gene_uniquename":"YLR441C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00733","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR441C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02522","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004433","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR441C"}


id: YLR442C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SIR3","product":"Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; required for telomere hypercluster formation in quiescent yeast cells; has paralog ORC1 from whole genome duplication","secondary_identifier":"SGD:S000004434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR442C"}


id: YLR443W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM7","product":"Putative integral membrane protein with a role in calcium uptake; non-essential protein; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency","secondary_identifier":"SGD:S000004435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR443W"}


id: YLR444C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004436","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR444C"}


id: YLR445W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GMC2","product":"Protein involved in meiotic crossing over; component of the Synaptonemal Complex (SC) along with Ecm11p; required for the efficient loading of the SC transverse filament protein, Zip1p; promotes SUMOylation of Ecm11p; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor; also detected in peroxisomes","secondary_identifier":"SGD:S000004437","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR445W"}


id: YLR446W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NGK1","product":"N-acetylglucosamine (GlcNAc) kinase; requires a divalent cation and a broad range of NTPs as phosphoryl donor to generate GlcNAc-6-phosphate, a substrate for glycan biosynthesis; promotes UDP-GlcNAc biosynthesis a precursor for chitin production; phylogenically distinct from known GlcNAc kinases and hexokinases; transcript is upregulated during sporulation and the unfolded protein response; contains a hexokinase-like ATPase domain; non-essential gene","secondary_identifier":"SGD:S000004438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR446W"}


id: YLR447C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01913":null,"YLR447C":null},"has_protein_features":false,"name":"VMA6","ortholog_annotations":[{"gene_uniquename":"YLR447C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01913","reference_uniquename":"PMID:29761456"}],"product":"Subunit d of the V0 integral membrane domain of V-ATPase; part of the electrogenic proton pump found in the endomembrane system; required for V1 domain assembly on the vacuolar membrane; the V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase) has five subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR447C"}


id: YLR448W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03666":null,"YLR448W":null},"has_protein_features":false,"name":"RPL6B","ortholog_annotations":[{"gene_uniquename":"YLR448W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03666","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004440","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR448W"}


id: YLR449W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01005":null,"SJAG_03905":null,"YLR449W":null},"has_protein_features":false,"name":"FPR4","ortholog_annotations":[{"gene_uniquename":"YLR449W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01005","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR449W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03905","reference_uniquename":"PMID:29761456"}],"product":"Nuclear peptidyl-prolyl cis-trans isomerase (PPIase); impacts expression of multiple genes via its role in nucleosome assembly; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones; role in rDNA maintenance; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; contains a nucleoplasmin-like fold and can form pentamers","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR449W"}


id: YLR450W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03715":null,"YLR450W":null},"has_protein_features":false,"name":"HMG2","ortholog_annotations":[{"gene_uniquename":"YLR450W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03715","reference_uniquename":"PMID:29761456"}],"product":"HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at nuclear periphery upon DNA replication stress; primarily expressed on the peri-membrane side of the ER; human homolog HMGCR can complement yeast hmg2 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004442","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR450W"}


id: YLR451W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LEU3","product":"Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation","secondary_identifier":"SGD:S000004443","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR451W"}


id: YLR452C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00990":null,"YLR452C":null},"has_protein_features":false,"name":"SST2","ortholog_annotations":[{"gene_uniquename":"YLR452C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00990","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein for Gpa1p; regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004444","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR452C"}


id: YLR453C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RIF2","product":"Protein that binds to the Rap1p C-terminus; inhibits MRX-dependent Tel1p activity by acting directly on Rad50p and discharging its activated ATP-bound state, thereby rendering the MRX complex incompetent for Tel1p activation; acts synergistically with Rif1p to help control telomere length, establish telomeric silencing; deletion results in telomere elongation; RIF2 has paralog ORC4 that arose from the whole genome duplication","secondary_identifier":"SGD:S000004445","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR453C"}


id: YLR454W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01564":null,"YLR454W":null},"has_protein_features":false,"name":"FMP27","ortholog_annotations":[{"gene_uniquename":"YLR454W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01564","reference_uniquename":"PMID:29761456"}],"product":"Protein with structural similarity to lipid transport protein Vps13p; localizes to multiple membrane contact sites between organelles including mitochondria–ER contact sites; non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004446","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR454W"}


id: YLR455W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00411":null,"SJAG_00545":null,"SJAG_01009":null,"YLR455W":null},"has_protein_features":false,"name":"PDP3","ortholog_annotations":[{"gene_uniquename":"YLR455W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00411","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR455W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00545","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR455W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01009","reference_uniquename":"PMID:29761456"}],"product":"Component of the NuA3b histone acetyltransferase complex; binds to Pol II and stimulates elongation; regulates interaction between NuA3b and H3K36me3 at transcribed regions of genes; contains PWWP domain; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia; extensive sequence similarity (~25% identity; ~39% similarity) to the N-terminal region of human NDF","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004447","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR455W"}


id: YLR456W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02770":null,"YLR456W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR456W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02770","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; predicted to encode a pyridoxal 5'-phosphate synthase based on sequence similarity but purified protein does not possess this activity, nor does it bind flavin mononucleotide (FMN); null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004448","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR456W"}


id: YLR457C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NBP1","product":"Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004449","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR457C"}


id: YLR458W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1/YLR457C gene required for mitosis","secondary_identifier":"SGD:S000004450","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR458W"}


id: YLR459W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02776":null,"YLR459W":null},"has_protein_features":false,"name":"GAB1","ortholog_annotations":[{"gene_uniquename":"YLR459W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02776","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the glycosylphosphatidylinositol transamidase complex; involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or the lipid portion of GPI; ortholog of human PIGU; partially complements a class U CHO cell line with a mutation in the PIGU ortholog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004451","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR459W"}


id: YLR460C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Member of the quinone oxidoreductase family; up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine","secondary_identifier":"SGD:S000004452","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR460C"}


id: YLR461W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU4","product":"Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme","secondary_identifier":"SGD:S000004453","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR461W"}


id: YLR462W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function with similarity to helicases; YLR462W is within the telomere on the right arm of chromosome XII","secondary_identifier":"SGD:S000004454","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR462W"}


id: YLR463C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORFs YLR462W and YLR464W","secondary_identifier":"SGD:S000004455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR463C"}


id: YLR464W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; intron is predicted but not detected experimentally; YLR464W overlaps the verified gene YRF1-4/YLR466W and two dubious ORFs YLR463C and YLR465C","secondary_identifier":"SGD:S000004456","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR464W"}


id: YLR465C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BSC3","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 100% of YLR465C overlaps the uncharacterized ORF YLR464W and 86% of YLR465C overlaps the verified gene YRF1-4","secondary_identifier":"SGD:S000004457","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR465C"}


id: YLR466C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YRF1-4/YLR466W","secondary_identifier":"SGD:S000028685","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR466C-A"}


id: YLR466C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000028686","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR466C-B"}


id: YLR466W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YRF1-4","product":"Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p","secondary_identifier":"SGD:S000004458","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR466W"}


id: YLR467C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YRF1-4/YLR466W","secondary_identifier":"SGD:S000028687","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR467C-A"}


id: YLR467W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YRF1-5","product":"Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p","secondary_identifier":"SGD:S000004459","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR467W"}


id: YML001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03072":null,"SJAG_03137":null,"YML001W":null},"has_protein_features":false,"name":"YPT7","ortholog_annotations":[{"gene_uniquename":"YML001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03072","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03137","reference_uniquename":"PMID:29761456"}],"product":"Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004460","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML001W"}


id: YML002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01309":null,"YML002W":null},"has_protein_features":false,"name":"VRL1","ortholog_annotations":[{"gene_uniquename":"YML002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01309","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; expression induced by heat and by calcium shortage; in many strains, YML002W is continuous with YML003W, and is predicted to encode a single protein of 1090 aa with a full-length VPS9 domain; in strains S288C, W303, and CEN.PK, a single thymine residue is deleted near the 3' end of YML003W at ChrXIII:264337, causing a frameshift and premature stop codon, truncating YML003W","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004461","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML002W"}


id: YML003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01309":null,"YML003W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YML003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01309","reference_uniquename":"PMID:26896847"}],"product":"Truncated 5' end of YML002W; in many strains, YML002W is continuous with YML003W, and is predicted to encode a single protein of 1090 aa with a full-length VPS9 domain; in strains S288C, W303, and CEN.PK, a single thymine residue is deleted near the 3' end of YML003W at ChrXIII:264337, causing a frameshift and premature stop codon, truncating YML003W","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004462","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML003W"}


id: YML004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04726":null,"YML004C":null},"has_protein_features":false,"name":"GLO1","ortholog_annotations":[{"gene_uniquename":"YML004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04726","reference_uniquename":"PMID:29761456"}],"product":"Monomeric glyoxalase I; catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; required for full activity of O-acetyl homoserine sulfhydrylase, Met17p; expression regulated by methylglyoxal levels and osmotic stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004463","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML004C"}


id: YML005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04735":null,"YML005W":null},"has_protein_features":false,"name":"TRM12","ortholog_annotations":[{"gene_uniquename":"YML005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04735","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine-dependent methyltransferase; required for wybutosine formation in phenylalanine-accepting tRNA; member of the seven beta-strand family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004464","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML005W"}


id: YML006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GIS4","product":"CAAX box containing protein of unknown function; proposed to be involved in the RAS/cAMP signaling pathway","secondary_identifier":"SGD:S000004465","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML006C"}


id: YML007C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIN4","product":"Mitochondrial protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria","secondary_identifier":"SGD:S000007621","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML007C-A"}


id: YML007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04036":null,"YML007W":null},"has_protein_features":false,"name":"YAP1","ortholog_annotations":[{"gene_uniquename":"YML007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04036","reference_uniquename":"PMID:29761456"}],"product":"Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; relative distribution to the nucleus increases upon DNA replication stress; YAP1 has a paralog, CAD1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004466","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML007W"}


id: YML008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03531":null,"YML008C":null},"has_protein_features":false,"name":"ERG6","ortholog_annotations":[{"gene_uniquename":"YML008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03531","reference_uniquename":"PMID:29761456"}],"product":"Delta(24)-sterol C-methyltransferase; converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to lipid particles, the plasma membrane-associated endoplasmic reticulum, and the mitochondrial outer membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004467","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML008C"}


id: YML009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02836":null,"YML009C":null},"has_protein_features":false,"name":"MRPL39","ortholog_annotations":[{"gene_uniquename":"YML009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02836","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004468","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML009C"}


id: YML009C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORFs SPT5/YML010W and YML009W-B","secondary_identifier":"SGD:S000004469","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML009C-A"}


id: YML009W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition","secondary_identifier":"SGD:S000004471","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML009W-B"}


id: YML010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02097":null,"YML010W":null},"has_protein_features":false,"name":"SPT5","ortholog_annotations":[{"gene_uniquename":"YML010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02097","reference_uniquename":"PMID:29761456"}],"product":"Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and in concert with RNAP I and II has multiple roles regulating transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; interacts with DNA upstream of RNAPII and the non-template strand of the transcription bubble; Spt5p is the only transcription elongation factor conserved in all domains of life","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004470","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML010W"}


id: YML011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RAD33","product":"Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus","secondary_identifier":"SGD:S000004472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML011C"}


id: YML012C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1","secondary_identifier":"SGD:S000004474","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML012C-A"}


id: YML012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00357":null,"YML012W":null},"has_protein_features":false,"name":"ERV25","ortholog_annotations":[{"gene_uniquename":"YML012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00357","reference_uniquename":"PMID:29761456"}],"product":"Member of the p24 family involved in ER to Golgi transport; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1, Erp2p, and Emp24,","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004473","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML012W"}


id: YML013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01585":null,"YML013W":null},"has_protein_features":false,"name":"UBX2","ortholog_annotations":[{"gene_uniquename":"YML013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01585","reference_uniquename":"PMID:29761456"}],"product":"Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis; required for mitochondrial protein translocation-associated degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004475","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML013W"}


id: YML014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02042":null,"YML014W":null},"has_protein_features":false,"name":"TRM9","ortholog_annotations":[{"gene_uniquename":"YML014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02042","reference_uniquename":"PMID:29761456"}],"product":"tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004476","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML014W"}


id: YML015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03285":null,"YML015C":null},"has_protein_features":false,"name":"TAF11","ortholog_annotations":[{"gene_uniquename":"YML015C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03285","reference_uniquename":"PMID:29761456"}],"product":"TFIID subunit (40 kDa); involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004477","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML015C"}


id: YML016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04426":null,"YML016C":null},"has_protein_features":false,"name":"PPZ1","ortholog_annotations":[{"gene_uniquename":"YML016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04426","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004478","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML016C"}


id: YML017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PSP2","product":"Asn rich cytoplasmic protein with a role in clathrin suppresion; contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing","secondary_identifier":"SGD:S000004479","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML017W"}


id: YML018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03138":null,"YML018C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YML018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03138","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004480","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML018C"}


id: YML019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03333":null,"YML019W":null},"has_protein_features":false,"name":"OST6","ortholog_annotations":[{"gene_uniquename":"YML019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03333","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004481","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML019W"}


id: YML020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03134":null,"YML020W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YML020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03134","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004482","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML020W"}


id: YML021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02528":null,"YML021C":null},"has_protein_features":false,"name":"UNG1","ortholog_annotations":[{"gene_uniquename":"YML021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02528","reference_uniquename":"PMID:29761456"}],"product":"Uracil-DNA glycosylase; required for repair of uracil in DNA formed by spontaneous cytosine deamination; efficiently excises uracil from single-stranded DNA in vivo; not required for strand-specific mismatch repair; cell-cycle regulated, expressed in late G1; localizes to mitochondria and nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004483","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML021C"}


id: YML022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01859":null,"YML022W":null},"has_protein_features":false,"name":"APT1","ortholog_annotations":[{"gene_uniquename":"YML022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01859","reference_uniquename":"PMID:29761456"}],"product":"Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004484","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML022W"}


id: YML023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04932":null,"YML023C":null},"has_protein_features":false,"name":"NSE5","ortholog_annotations":[{"gene_uniquename":"YML023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04932","reference_uniquename":"PMID:29761456"}],"product":"Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004485","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML023C"}


id: YML024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04168":null,"SJAG_04204":null,"YML024W":null},"has_protein_features":false,"name":"RPS17A","ortholog_annotations":[{"gene_uniquename":"YML024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04168","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04204","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004486","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML024W"}


id: YML025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03649":null,"YML025C":null},"has_protein_features":false,"name":"YML6","ortholog_annotations":[{"gene_uniquename":"YML025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03649","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004487","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML025C"}


id: YML026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02861":null,"SJAG_04188":null,"YML026C":null},"has_protein_features":false,"name":"RPS18B","ortholog_annotations":[{"gene_uniquename":"YML026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02861","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04188","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004488","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML026C"}


id: YML027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01157":null,"YML027W":null},"has_protein_features":false,"name":"YOX1","ortholog_annotations":[{"gene_uniquename":"YML027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01157","reference_uniquename":"PMID:29761456"}],"product":"Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; phosphorylated by Cdc28p; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004489","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML027W"}


id: YML028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01199":null,"YML028W":null},"has_protein_features":false,"name":"TSA1","ortholog_annotations":[{"gene_uniquename":"YML028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01199","reference_uniquename":"PMID:29761456"}],"product":"Thioredoxin peroxidase; acts as both ribosome-associated and free cytoplasmic antioxidant; self-associates to form a HMW chaperone complex under oxidative stress; chaperone activity essential for growth in zinc deficiency; hydrogen peroxide receptor and signal transducer in a light sensing pathway; required for telomere length maintenance; binds and modulates Cdc19p activity; protein abundance increases and forms cytoplasmic foci during DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004490","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML028W"}


id: YML029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"USA1","product":"Scaffold subunit of the Hrd1p ubiquitin ligase; also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p","secondary_identifier":"SGD:S000004491","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML029W"}


id: YML030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02975":null,"YML030W":null},"has_protein_features":false,"name":"RCF1","ortholog_annotations":[{"gene_uniquename":"YML030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02975","reference_uniquename":"PMID:29761456"}],"product":"Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004492","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML030W"}


id: YML031C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF NDC1/YML031W","secondary_identifier":"SGD:S000028809","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML031C-A"}


id: YML031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03200":null,"YML031W":null},"has_protein_features":false,"name":"NDC1","ortholog_annotations":[{"gene_uniquename":"YML031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03200","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004493","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML031W"}


id: YML032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02079":null,"SJAG_04530":null,"YML032C":null},"has_protein_features":false,"name":"RAD52","ortholog_annotations":[{"gene_uniquename":"YML032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02079","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04530","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in homologous recombination; attenuates resection of DNA double-strand break ends and stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA (ssDNA); anneals complementary ssDNA; involved in the repair of double-strand breaks in DNA during vegetative growth, meiosis and UV induced sister chromatid recombination; forms a homodecameric ring; phosphorylation by Cdc28p in G2/M phase promotes Rad52p ring interaction that leads to superstructure formation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004494","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML032C"}


id: YML033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YML033W was originally annotated as an independent ORF, but was later demonstrated to be an exon of an adjacent ORF, YML034W","secondary_identifier":"SGD:S000082441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML033W"}


id: YML034C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SRC1/YML034W","secondary_identifier":"SGD:S000004499","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML034C-A"}


id: YML034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01745":null,"SJAG_03449":null,"YML034W":null},"has_protein_features":false,"name":"SRC1","ortholog_annotations":[{"gene_uniquename":"YML034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01745","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03449","reference_uniquename":"PMID:29761456"}],"product":"Chromosome linkage inner nuclear membrane protein; CLIP, involved in perinuclear chromosome tethering and rDNA repeat stability; enriched at telomeres and subtelomeric regions; associates with and regulates subtelomeric genes, interacting with TREX (transcription export) factors; produces two splice variants with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant is aneuploidy tolerant; SRC1 has a paralog, HEH2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004497","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML034W"}


id: YML035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04123":null,"YML035C":null},"has_protein_features":false,"name":"AMD1","ortholog_annotations":[{"gene_uniquename":"YML035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04123","reference_uniquename":"PMID:29761456"}],"product":"AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004498","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML035C"}


id: YML036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04201":null,"YML036W":null},"has_protein_features":false,"name":"CGI121","ortholog_annotations":[{"gene_uniquename":"YML036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04201","reference_uniquename":"PMID:29761456"}],"product":"Component of the EKC/KEOPS complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; Cgi121p is dispensable for tRNA modification; other complex members are Bud32p, Kae1p, Pcc1p, and Gon7p; ortholog of human TPRKB","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004500","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML036W"}


id: YML037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LFT1","product":"Putative protein of unknown function; binds HEATR5 protein Laa1p; has some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene","secondary_identifier":"SGD:S000004501","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML037C"}


id: YML038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04406":null,"YML038C":null},"has_protein_features":false,"name":"YMD8","ortholog_annotations":[{"gene_uniquename":"YML038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04406","reference_uniquename":"PMID:29761456"}],"product":"Putative nucleotide sugar transporter; has similarity to Vrg4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004502","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML038C"}


id: YML041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05192":null,"YML041C":null},"has_protein_features":false,"name":"VPS71","ortholog_annotations":[{"gene_uniquename":"YML041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05192","reference_uniquename":"PMID:29761456"}],"product":"Nucleosome-binding component of the SWR1 complex; SWR1 exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004505","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML041C"}


id: YML042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CAT2","product":"Carnitine acetyl-CoA transferase; present in both mitochondria and peroxisomes; transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes","secondary_identifier":"SGD:S000004506","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML042W"}


id: YML043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00692":null,"YML043C":null},"has_protein_features":false,"name":"RRN11","ortholog_annotations":[{"gene_uniquename":"YML043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00692","reference_uniquename":"PMID:29761456"}],"product":"Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004507","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML043C"}


id: YML046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00058":null,"YML046W":null},"has_protein_features":false,"name":"PRP39","ortholog_annotations":[{"gene_uniquename":"YML046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00058","reference_uniquename":"PMID:29761456"}],"product":"U1 snRNP protein involved in splicing; contains multiple tetriatricopeptide repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004509","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML046W"}


id: YML047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRM6","product":"Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; member of a fungal-specific gene family; PRM6 has a paralog, KCH1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004510","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML047C"}


id: YML047W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF PRM6/YML047C","secondary_identifier":"SGD:S000004512","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML047W-A"}


id: YML048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GSF2","product":"Endoplasmic reticulum (ER) localized integral membrane protein; may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression","secondary_identifier":"SGD:S000004511","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML048W"}


id: YML049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02185":null,"YML049C":null},"has_protein_features":false,"name":"RSE1","ortholog_annotations":[{"gene_uniquename":"YML049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02185","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004513","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML049C"}


id: YML050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM32","product":"2Fe-2S mitochondrial protein involved in redox quality control; may maintain protein redox status by targeting oxidation sensitive cysteine residues; bishistidinyl coordinated, non-Rieske [2Fe-2S] cluster containing thiredoxin-like ferredoxin; forms a functional complex with Osm1p and Erv1p in the IMS; required for assembly of numerous mitochondrial import complexes; essential for anaerobiosis; localizes to the mitochondrial matrix and intermembrane space (IMS); homologous to APD1","secondary_identifier":"SGD:S000004514","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML050W"}


id: YML051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GAL80","product":"Transcriptional regulator involved in the repression of GAL genes; involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding","secondary_identifier":"SGD:S000004515","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML051W"}


id: YML052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SUR7","product":"Plasma membrane protein, component of eisosomes; long-lived protein that remains stable in eisosomes of mother cells while other eisosome proteins, Pil1p and Lsp1p, turn over; may function to anchor the eisosome in place; sporulation and plasma membrane sphingolipid content are altered in mutants; localizes to furrow-like invaginations (MCC patches)","secondary_identifier":"SGD:S000004516","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML052W"}


id: YML053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene","secondary_identifier":"SGD:S000004517","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML053C"}


id: YML054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CYB2","product":"Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions","secondary_identifier":"SGD:S000004518","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML054C"}


id: YML054C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028573","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML054C-A"}


id: YML055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02867":null,"YML055W":null},"has_protein_features":false,"name":"SPC2","ortholog_annotations":[{"gene_uniquename":"YML055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02867","reference_uniquename":"PMID:29761456"}],"product":"Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; inhibits SRP-independent translocation into the ER with STE24; homologous to mammalian SPC25; other members of the complex are Spc1p, Spc1p, and Sec11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004519","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML055W"}


id: YML056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01298":null,"YML056C":null},"has_protein_features":false,"name":"IMD4","ortholog_annotations":[{"gene_uniquename":"YML056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01298","reference_uniquename":"PMID:29761456"}],"product":"Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD4 has a paralog, IMD3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004520","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML056C"}


id: YML057C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W","secondary_identifier":"SGD:S000004522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML057C-A"}


id: YML057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03631":null,"YML057W":null},"has_protein_features":false,"name":"CMP2","ortholog_annotations":[{"gene_uniquename":"YML057W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03631","reference_uniquename":"PMID:29761456"}],"product":"Calcineurin A; one isoform (the other is Cna1p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CMP2 has a paralog, CNA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML057W"}


id: YML058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SML1","product":"Ribonucleotide reductase inhibitor; involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; SML1 has a paralog, DIF1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML058W"}


id: YML058W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HUG1","product":"Ribonucleotide reductase inhibitor; intrinsically disordered protein that binds to and inhibits Rnr2p; involved in the Mec1p-mediated checkpoint pathway; transcription is induced by genotoxic stress and by activation of the Rad53p pathway; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000007472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML058W-A"}


id: YML059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04110":null,"YML059C":null},"has_protein_features":false,"name":"NTE1","ortholog_annotations":[{"gene_uniquename":"YML059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04110","reference_uniquename":"PMID:29761456"}],"product":"Serine esterase; homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004524","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML059C"}


id: YML060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01119":null,"YML060W":null},"has_protein_features":false,"name":"OGG1","ortholog_annotations":[{"gene_uniquename":"YML060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01119","reference_uniquename":"PMID:26896847"}],"product":"Nuclear and mitochondrial glycosylase/lyase; specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004525","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML060W"}


id: YML061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03780":null,"YML061C":null},"has_protein_features":false,"name":"PIF1","ortholog_annotations":[{"gene_uniquename":"YML061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03780","reference_uniquename":"PMID:29761456"}],"product":"DNA helicase, potent G-quadruplex DNA binder/unwinder; possesses strand annealing activity; promotes DNA synthesis during break-induced replication; involved in crossover recombination; works with Hrq1p to maintain telomere length homeostasis; translation from different start sites produces mitochondrial (DNA repair and recombination) and nuclear (catalytic inhibitor of telomerase) isoforms; mutations affect Zn, Fe homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML061C"}


id: YML062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04202":null,"YML062C":null},"has_protein_features":false,"name":"MFT1","ortholog_annotations":[{"gene_uniquename":"YML062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04202","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the THO complex; THO is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004527","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML062C"}


id: YML063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00733":null,"SJAG_02522":null,"YML063W":null},"has_protein_features":false,"name":"RPS1B","ortholog_annotations":[{"gene_uniquename":"YML063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00733","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02522","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004528","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML063W"}


id: YML064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03342":null,"YML064C":null},"has_protein_features":false,"name":"TEM1","ortholog_annotations":[{"gene_uniquename":"YML064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03342","reference_uniquename":"PMID:29761456"}],"product":"GTPase involved in initiation of Mitotic Exit Network (MEN); GTP-binding protein of the Ras superfamily; accumulates at daughter spindle pole body and activates MEN kinase cascade; controls actomyosin and septin dynamics during cytokinesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004529","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML064C"}


id: YML065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03927":null,"YML065W":null},"has_protein_features":false,"name":"ORC1","ortholog_annotations":[{"gene_uniquename":"YML065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03927","reference_uniquename":"PMID:29761456"}],"product":"Largest subunit of the origin recognition complex; involved in directing DNA replication by binding to replication origins; also involved in transcriptional silencing; exhibits ATPase activity; role in chromatin organization at replication origins, along with chromatin remodellers; ORC1 has a paralog, SIR3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004530","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML065W"}


id: YML066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SMA2","product":"Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation","secondary_identifier":"SGD:S000004531","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML066C"}


id: YML067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03933":null,"YML067C":null},"has_protein_features":false,"name":"ERV41","ortholog_annotations":[{"gene_uniquename":"YML067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03933","reference_uniquename":"PMID:29761456"}],"product":"Protein localized to COPII-coated vesicles; forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004532","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML067C"}


id: YML068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ITT1","product":"Protein that modulates the efficiency of translation termination; interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins","secondary_identifier":"SGD:S000004533","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML068W"}


id: YML069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03128":null,"YML069W":null},"has_protein_features":false,"name":"POB3","ortholog_annotations":[{"gene_uniquename":"YML069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03128","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004534","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML069W"}


id: YML070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04320":null,"YML070W":null},"has_protein_features":false,"name":"DAK1","ortholog_annotations":[{"gene_uniquename":"YML070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04320","reference_uniquename":"PMID:29761456"}],"product":"Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004535","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML070W"}


id: YML071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03054":null,"YML071C":null},"has_protein_features":false,"name":"COG8","ortholog_annotations":[{"gene_uniquename":"YML071C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03054","reference_uniquename":"PMID:29761456"}],"product":"Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004536","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML071C"}


id: YML072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01437":null,"SJAG_04413":null,"SJAG_04417":null,"YML072C":null},"has_protein_features":false,"name":"TCB3","ortholog_annotations":[{"gene_uniquename":"YML072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01437","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04413","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04417","reference_uniquename":"PMID:29761456"}],"product":"Lipid-binding ER tricalbin involved in ER-plasma membrane tethering; one of at least 7 proteins (Ice2p, Ist2p, Scs2/Scs22p, Tcb1-Tcb3p) that affect cER tethering and contact with the plasma membrane; regulates PI4P levels by controlling access of Sac1p to its substrate PI4P in the PM; regulates PM phospholipid homeostasis; involved in intermembrane phospholipid transfer; also localizes to the mitochondria in a phosphorylated state and is enriched in bud membranes; mRNA is targeted to the bud tip","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004537","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML072C"}


id: YML073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03666":null,"YML073C":null},"has_protein_features":false,"name":"RPL6A","ortholog_annotations":[{"gene_uniquename":"YML073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03666","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004538","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML073C"}


id: YML074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01005":null,"SJAG_03905":null,"YML074C":null},"has_protein_features":false,"name":"FPR3","ortholog_annotations":[{"gene_uniquename":"YML074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01005","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03905","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; affects expression of multiple genes via its role in nucleosome assembly; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; FPR3 has a paralog, FPR4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004539","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML074C"}


id: YML075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03715":null,"YML075C":null},"has_protein_features":false,"name":"HMG1","ortholog_annotations":[{"gene_uniquename":"YML075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03715","reference_uniquename":"PMID:29761456"}],"product":"HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; expressed almost exclusively on the peri-nuclear side of the ER; human homolog HMGCR can complement yeast hmg1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004540","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML075C"}


id: YML076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"WAR1","product":"Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively","secondary_identifier":"SGD:S000004541","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML076C"}


id: YML077W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04837":null,"YML077W":null},"has_protein_features":false,"name":"BET5","ortholog_annotations":[{"gene_uniquename":"YML077W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04837","reference_uniquename":"PMID:29761456"}],"product":"Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); human homology TRAPPC1 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004542","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML077W"}


id: YML078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01246":null,"YML078W":null},"has_protein_features":false,"name":"CPR3","ortholog_annotations":[{"gene_uniquename":"YML078W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01246","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004543","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML078W"}


id: YML079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CFF1","product":"Protein required for production of 4-hydroxy-5-methylfuran-3(2H)-one (MHF); cupin superfamily protein; has structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to nucleus and cytoplasm","secondary_identifier":"SGD:S000004544","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML079W"}


id: YML080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00174":null,"YML080W":null},"has_protein_features":false,"name":"DUS1","ortholog_annotations":[{"gene_uniquename":"YML080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00174","reference_uniquename":"PMID:29761456"}],"product":"Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNAs at U16 and U17 of the D loop","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004545","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML080W"}


id: YML081C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02105":null,"YML081C-A":null},"has_protein_features":false,"name":"ATP18","ortholog_annotations":[{"gene_uniquename":"YML081C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02105","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML081C-A"}


id: YML081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03346":null,"YML081W":null},"has_protein_features":false,"name":"TDA9","ortholog_annotations":[{"gene_uniquename":"YML081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03346","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor that regulates acetate production; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004546","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML081W"}


id: YML082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03102":null,"YML082W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YML082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03102","reference_uniquename":"PMID:29761456"}],"product":"Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; not an essential gene; YML082W has a paralog, STR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004547","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML082W"}


id: YML083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions","secondary_identifier":"SGD:S000004548","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML083C"}


id: YML084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004549","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML084W"}


id: YML085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02509":null,"SJAG_04387":null,"YML085C":null},"has_protein_features":false,"name":"TUB1","ortholog_annotations":[{"gene_uniquename":"YML085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02509","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04387","reference_uniquename":"PMID:29761456"}],"product":"Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004550","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML085C"}


id: YML086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00265":null,"YML086C":null},"has_protein_features":false,"name":"ALO1","ortholog_annotations":[{"gene_uniquename":"YML086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00265","reference_uniquename":"PMID:29761456"}],"product":"D-Arabinono-1,4-lactone oxidase; catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress; null mutant shows improved incorporation efficiency of noncanonical amino acids in place of amber stop codon","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004551","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML086C"}


id: YML087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM33","product":"Protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004552","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML087C"}


id: YML088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01617":null,"YML088W":null},"has_protein_features":false,"name":"UFO1","ortholog_annotations":[{"gene_uniquename":"YML088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01617","reference_uniquename":"PMID:29761456"}],"product":"F-box receptor protein; subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitination by SCF and subsequent degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004553","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML088W"}


id: YML089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage","secondary_identifier":"SGD:S000004554","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML089C"}


id: YML090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source","secondary_identifier":"SGD:S000004555","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML090W"}


id: YML091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RPM2","product":"Protein subunit of mitochondrial RNase P; has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus","secondary_identifier":"SGD:S000004556","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML091C"}


id: YML092C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02502":null,"YML092C":null},"has_protein_features":false,"name":"PRE8","ortholog_annotations":[{"gene_uniquename":"YML092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02502","reference_uniquename":"PMID:29761456"}],"product":"Alpha 2 subunit of the 20S proteasome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004557","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML092C"}


id: YML093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04424":null,"YML093W":null},"has_protein_features":false,"name":"UTP14","ortholog_annotations":[{"gene_uniquename":"YML093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04424","reference_uniquename":"PMID:29761456"}],"product":"Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004558","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML093W"}


id: YML094C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO","secondary_identifier":"SGD:S000004561","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML094C-A"}


id: YML094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04012":null,"YML094W":null},"has_protein_features":false,"name":"GIM5","ortholog_annotations":[{"gene_uniquename":"YML094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04012","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004559","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML094W"}


id: YML095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02828":null,"YML095C":null},"has_protein_features":false,"name":"RAD10","ortholog_annotations":[{"gene_uniquename":"YML095C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02828","reference_uniquename":"PMID:29761456"}],"product":"Single-stranded DNA endonuclease (with Rad1p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004560","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML095C"}


id: YML096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02832":null,"YML096W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YML096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02832","reference_uniquename":"PMID:29761456"}],"product":"Putative protein with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004562","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML096W"}


id: YML097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02833":null,"YML097C":null},"has_protein_features":false,"name":"VPS9","ortholog_annotations":[{"gene_uniquename":"YML097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02833","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF) and ubiquitin receptor; involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); stimulates the intrinsic guanine nucleotide exchange activity of Rab family members (Vps21p/Ypt52p/Ypt53p); partially redundant with GEF MUK1; required for localization of the CORVET complex to endosomes; similar to mammalian ras inhibitors; contains a Ub-interacting CUE domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004563","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML097C"}


id: YML098W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04654":null,"YML098W":null},"has_protein_features":false,"name":"TAF13","ortholog_annotations":[{"gene_uniquename":"YML098W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04654","reference_uniquename":"PMID:29761456"}],"product":"TFIID subunit (19 kDa); involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004564","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML098W"}


id: YML099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ARG81","product":"Zinc finger transcription factor involved in arginine-responsive genes; Zn(2)-Cys(6) binuclear cluster domain type; involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p","secondary_identifier":"SGD:S000004565","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML099C"}


id: YML099W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ARG81/YML099C","secondary_identifier":"SGD:S000004567","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML099W-A"}


id: YML100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00129":null,"SJAG_00182":null,"SJAG_01427":null,"YML100W":null},"has_protein_features":false,"name":"TSL1","ortholog_annotations":[{"gene_uniquename":"YML100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00129","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00182","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YML100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01427","reference_uniquename":"PMID:29761456"}],"product":"Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; contributes to survival to acute lethal heat stress; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML100W"}


id: YML100W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028688","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML100W-A"}


id: YML101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01051":null,"YML101C":null},"has_protein_features":false,"name":"CUE4","ortholog_annotations":[{"gene_uniquename":"YML101C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01051","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004568","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML101C"}


id: YML101C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004569","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML101C-A"}


id: YML102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02198":null,"YML102W":null},"has_protein_features":false,"name":"CAC2","ortholog_annotations":[{"gene_uniquename":"YML102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02198","reference_uniquename":"PMID:29761456"}],"product":"Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure, deactivation of the DNA damage checkpoint after DNA repair, chromatin dynamics during transcription; and repression of divergent transcription; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004570","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML102W"}


id: YML103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00375":null,"YML103C":null},"has_protein_features":false,"name":"NUP188","ortholog_annotations":[{"gene_uniquename":"YML103C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00375","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004571","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML103C"}


id: YML104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04221":null,"YML104C":null},"has_protein_features":false,"name":"MDM1","ortholog_annotations":[{"gene_uniquename":"YML104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04221","reference_uniquename":"PMID:29761456"}],"product":"PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs; anchored in the ER membrane at nucleus-vacuole junctions and binds phosphatidylinositol 3-phosphate (PtdIns-3-P) in the vacuolar membrane via its Phox homology (PX) domain; expressed predominantly in late G1 to early S phase of the cell cycle; mutation affects nuclear and mitochondrial transmission to daughter buds; similar to 4 human genes, one of which (SNX14) is associated with neurological disease","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004572","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML104C"}


id: YML105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02456":null,"YML105C":null},"has_protein_features":false,"name":"SEC65","ortholog_annotations":[{"gene_uniquename":"YML105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02456","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the signal recognition particle (SRP); involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004573","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML105C"}


id: YML106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00694":null,"YML106W":null},"has_protein_features":false,"name":"URA5","ortholog_annotations":[{"gene_uniquename":"YML106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00694","reference_uniquename":"PMID:29761456"}],"product":"Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004574","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML106W"}


id: YML107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05243":null,"YML107C":null},"has_protein_features":false,"name":"PML39","ortholog_annotations":[{"gene_uniquename":"YML107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05243","reference_uniquename":"PMID:29761456"}],"product":"Protein required for nuclear retention of unspliced pre-mRNAs; required along with Mlp1p and Pml1p; anchored to the nuclear pore complex through an interaction between its bimodular nuclear basket-interaction domain (NuBaID) and Mlp1p and Mlp2p; localizes to the nuclear basket enables linkage between subpopulations of Mlp1p; associates with the subset of nuclear pores farthest from the nucleolus; homologous to human ZC3HC1, a NuBaID containing protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004575","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML107C"}


id: YML108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000004576","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML108W"}


id: YML109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01901":null,"YML109W":null},"has_protein_features":false,"name":"ZDS2","ortholog_annotations":[{"gene_uniquename":"YML109W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01901","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004577","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML109W"}


id: YML110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01043":null,"YML110C":null},"has_protein_features":false,"name":"COQ5","ortholog_annotations":[{"gene_uniquename":"YML110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01043","reference_uniquename":"PMID:29761456"}],"product":"2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; respiratory defect of the null mutant is partially complemented by human COQ5","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004578","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML110C"}


id: YML111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUL2","product":"Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex; ubiquitin-binding adaptor involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004579","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML111W"}


id: YML112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01149":null,"YML112W":null},"has_protein_features":false,"name":"CTK3","ortholog_annotations":[{"gene_uniquename":"YML112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01149","reference_uniquename":"PMID:29761456"}],"product":"Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004580","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML112W"}


id: YML113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DAT1","product":"DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; relocalizes to the cytosol in response to hypoxia; not essential for viability","secondary_identifier":"SGD:S000004581","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML113W"}


id: YML114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00872":null,"YML114C":null},"has_protein_features":false,"name":"TAF8","ortholog_annotations":[{"gene_uniquename":"YML114C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00872","reference_uniquename":"PMID:29761456"}],"product":"TFIID subunit (65 kDa); involved in RNA polymerase II transcription initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004582","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML114C"}


id: YML115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00816":null,"YML115C":null},"has_protein_features":false,"name":"VAN1","ortholog_annotations":[{"gene_uniquename":"YML115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00816","reference_uniquename":"PMID:29761456"}],"product":"Component of the mannan polymerase I; complex contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004583","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML115C"}


id: YML116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATR1","product":"Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004584","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML116W"}


id: YML116W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000004586","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML116W-A"}


id: YML117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03498":null,"YML117W":null},"has_protein_features":false,"name":"NAB6","ortholog_annotations":[{"gene_uniquename":"YML117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03498","reference_uniquename":"PMID:26896847"}],"product":"mRNA-binding protein; binds to the 3'UTR of cell wall-related mRNAs and stabilizes these mRNAs, acting in parallel to cell wall integrity signaling to maintain expression of cell wall genes during stress; acts antagonistically to Nab6p; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004585","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML117W"}


id: YML118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04519":null,"YML118W":null},"has_protein_features":false,"name":"NGL3","ortholog_annotations":[{"gene_uniquename":"YML118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04519","reference_uniquename":"PMID:29761456"}],"product":"3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML118W"}


id: YML119W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate","secondary_identifier":"SGD:S000004588","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML119W"}


id: YML120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04152":null,"YML120C":null},"has_protein_features":false,"name":"NDI1","ortholog_annotations":[{"gene_uniquename":"YML120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04152","reference_uniquename":"PMID:29761456"}],"product":"NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in respiratory chain but does not pump protons, in contrast to higher eukaryotic multisubunit respiratory complex I; upon apoptotic stress, is activated in mitochondria by N-terminal cleavage, then translocates to cytoplasm to induce apoptosis; homolog of human AIFM2; yeast NDI1 complements several phenotypes of human cell line with mutated MT-ND4, implicated in Leber hereditary optic neuropathy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004589","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML120C"}


id: YML121W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00457":null,"YML121W":null},"has_protein_features":false,"name":"GTR1","ortholog_annotations":[{"gene_uniquename":"YML121W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00457","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TORC1-stimulating GTPase and EGO/GSE complex; subunit of Gtr1-Gtr2 GTPase that activates TORC1 in response to amino acid stimulation; subunit of EGO/GSE vacuolar membrane complex that regulates exit from rapamycin-induced growth arrest and sorting of Gap1p; involved in phosphate transport, telomeric chromatin silencing and oxidative stress response; activated by Iml1p (GAP) subunit of SEACIT complex; targeted to vacuole via AP-3 pathway; similar to human RagA and RagB","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004590","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML121W"}


id: YML122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YML122C is not an essential gene","secondary_identifier":"SGD:S000004591","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML122C"}


id: YML123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01033":null,"SJAG_04241":null,"YML123C":null},"has_protein_features":false,"name":"PHO84","ortholog_annotations":[{"gene_uniquename":"YML123C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01033","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML123C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04241","reference_uniquename":"PMID:29761456"}],"product":"High-affinity inorganic phosphate (Pi) transporter; also low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004592","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML123C"}


id: YML124C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02509":null,"SJAG_04387":null,"YML124C":null},"has_protein_features":false,"name":"TUB3","ortholog_annotations":[{"gene_uniquename":"YML124C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02509","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML124C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04387","reference_uniquename":"PMID:29761456"}],"product":"Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004593","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML124C"}


id: YML125C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PGA3","product":"Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004594","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML125C"}


id: YML126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04499":null,"YML126C":null},"has_protein_features":false,"name":"ERG13","ortholog_annotations":[{"gene_uniquename":"YML126C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04499","reference_uniquename":"PMID:29761456"}],"product":"3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase; catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004595","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML126C"}


id: YML127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01622":null,"YML127W":null},"has_protein_features":false,"name":"RSC9","ortholog_annotations":[{"gene_uniquename":"YML127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01622","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004596","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML127W"}


id: YML128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00680":null,"SJAG_03837":null,"YML128C":null},"has_protein_features":false,"name":"MSC1","ortholog_annotations":[{"gene_uniquename":"YML128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00680","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03837","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004597","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML128C"}


id: YML129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02480":null,"YML129C":null},"has_protein_features":false,"name":"COX14","ortholog_annotations":[{"gene_uniquename":"YML129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02480","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial cytochrome c oxidase (complex IV) assembly factor; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; located in the mitochondrial membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004598","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML129C"}


id: YML130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02489":null,"SJAG_02827":null,"YML130C":null},"has_protein_features":false,"name":"ERO1","ortholog_annotations":[{"gene_uniquename":"YML130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02489","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02827","reference_uniquename":"PMID:29761456"}],"product":"Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining ER redox balance; feedback regulated via reduction and oxidation of regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds; ero1-1 mutation complemented by human ERO1L","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004599","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML130C"}


id: YML131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01362":null,"SJAG_02151":null,"YML131W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YML131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01362","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YML131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02151","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004600","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML131W"}


id: YML132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS3","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000004601","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML132W"}


id: YML133C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative Y' element ATP-dependent helicase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron","secondary_identifier":"SGD:S000004602","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML133C"}


id: YML133W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YML133C","secondary_identifier":"SGD:S000028689","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML133W-A"}


id: YML133W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YML133C","secondary_identifier":"SGD:S000028690","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YML133W-B"}


id: YMR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01805":null,"YMR001C":null},"has_protein_features":false,"name":"CDC5","ortholog_annotations":[{"gene_uniquename":"YMR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01805","reference_uniquename":"PMID:29761456"}],"product":"Polo-like kinase required for mitotic exit; regulates mitotic spindle assembly, nuclear shape, and protein localization to the nucleolus and SPBs; controls targeting and activation of Rho1p at the division site via Rho1p-GEFs; role in adaptation to DNA damage promotes genome instability during replicative senescence; regulates meiotic commitment, spindle assembly, chiasmata formation, recombination intermediate resolution and SC disassembly; human homologs PLK1 and PLK3 complement cdc5 mutants","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004603","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR001C"}


id: YMR001C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028691","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR001C-A"}


id: YMR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIX17","product":"Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004604","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR002W"}


id: YMR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM34","product":"Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss","secondary_identifier":"SGD:S000004605","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR003W"}


id: YMR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MVP1","product":"Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with 'foot domain' of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004606","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR004W"}


id: YMR005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00741":null,"YMR005W":null},"has_protein_features":false,"name":"TAF4","ortholog_annotations":[{"gene_uniquename":"YMR005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00741","reference_uniquename":"PMID:29761456"}],"product":"TFIID subunit (48 kDa); involved in RNA polymerase II transcription initiation; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004607","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR005W"}


id: YMR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02091":null,"SJAG_02093":null,"SJAG_03204":null,"YMR006C":null},"has_protein_features":false,"name":"PLB2","ortholog_annotations":[{"gene_uniquename":"YMR006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02091","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02093","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03204","reference_uniquename":"PMID:29761456"}],"product":"Phospholipase B (lysophospholipase) involved in lipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR006C"}


id: YMR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YMR007W is not an essential gene","secondary_identifier":"SGD:S000004609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR007W"}


id: YMR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02091":null,"SJAG_02093":null,"SJAG_03204":null,"YMR008C":null},"has_protein_features":false,"name":"PLB1","ortholog_annotations":[{"gene_uniquename":"YMR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02091","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02093","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03204","reference_uniquename":"PMID:29761456"}],"product":"Phospholipase B (lysophospholipase) involved in lipid metabolism; required for efficient acyl chain remodeling of newly synthesized phosphatidylethanolamine-derived phosphatidylcholine; required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol; PLB1 has a paralog, PLB3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004610","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR008C"}


id: YMR008C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Novel ORF identified via pan-genome analysis; conserved in other strains of S. cerevisiae","secondary_identifier":"SGD:S000303813","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR008C-A"}


id: YMR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00309":null,"YMR009W":null},"has_protein_features":false,"name":"ADI1","ortholog_annotations":[{"gene_uniquename":"YMR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00309","reference_uniquename":"PMID:29761456"}],"product":"Acireductone dioxygenease involved in methionine salvage pathway; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions; human ortholog ADI1 can complement yeast adi1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004611","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR009W"}


id: YMR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ANY1","product":"Protein involved in phospholipid flippase function; null allele suppresses growth and membrane trafficking defects associated with all flippase null alleles; proposed function as a phospholipid scramblase that reduces membrane asymmetry; PQ loop family member; localizes to the endosome and trans-Golgi network; non-essential gene","secondary_identifier":"SGD:S000004612","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR010W"}


id: YMR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YMR011W":null},"has_protein_features":false,"name":"HXT2","ortholog_annotations":[{"gene_uniquename":"YMR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YMR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YMR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR011W"}


id: YMR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01741":null,"YMR012W":null},"has_protein_features":false,"name":"CLU1","ortholog_annotations":[{"gene_uniquename":"YMR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01741","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the eukaryotic translation initiation factor 3 (eIF3); component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation; can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant; eIF3 is also involved in programmed stop codon readthrough","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004614","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR012W"}


id: YMR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04231":null,"YMR013C":null},"has_protein_features":false,"name":"SEC59","ortholog_annotations":[{"gene_uniquename":"YMR013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04231","reference_uniquename":"PMID:29761456"}],"product":"Dolichol kinase; catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004615","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR013C"}


id: YMR013C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF SEC59/YML013C","secondary_identifier":"SGD:S000028847","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR013C-A"}


id: YMR013W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73","secondary_identifier":"SGD:S000007622","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR013W-A"}


id: YMR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01272":null,"YMR014W":null},"has_protein_features":false,"name":"BUD22","ortholog_annotations":[{"gene_uniquename":"YMR014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01272","reference_uniquename":"PMID:29761456"}],"product":"Protein required for rRNA maturation and ribosomal subunit biogenesis; required for 18S rRNA maturation; also required for small ribosomal subunit biogenesis; cosediments with pre-ribosomal particles; mutation decreases efficiency of +1 Ty1 frameshifting and transposition, and affects budding pattern","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004616","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR014W"}


id: YMR015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03249":null,"YMR015C":null},"has_protein_features":false,"name":"ERG5","ortholog_annotations":[{"gene_uniquename":"YMR015C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03249","reference_uniquename":"PMID:29761456"}],"product":"C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004617","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR015C"}


id: YMR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SOK2","product":"Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; relocalizes to the cytosol in response to hypoxia; SOK2 has a paralog, PHD1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004618","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR016C"}


id: YMR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00826":null,"YMR017W":null},"has_protein_features":false,"name":"SPO20","ortholog_annotations":[{"gene_uniquename":"YMR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00826","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific subunit of the t-SNARE complex; required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; binds to phosphatidic acid; SNAP-25 homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR017W"}


id: YMR018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00702":null,"YMR018W":null},"has_protein_features":false,"name":"PEX9","ortholog_annotations":[{"gene_uniquename":"YMR018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00702","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal membrane signal receptor for peroxisomal matrix proteins; oleate-inducible condition-specific import receptor for a subset of PTS1-containing matrix proteins; localizes to both the cytosol and the peroxisomal membrane; similar to human PEX5Rp, a peroxin protein 5 related protein; paralog of Pex5p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004620","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR018W"}


id: YMR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STB4","product":"Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay;","secondary_identifier":"SGD:S000004621","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR019W"}


id: YMR020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMS1","product":"Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis","secondary_identifier":"SGD:S000004622","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR020W"}


id: YMR021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00802":null,"SJAG_01694":null,"YMR021C":null},"has_protein_features":false,"name":"MAC1","ortholog_annotations":[{"gene_uniquename":"YMR021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00802","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01694","reference_uniquename":"PMID:29761456"}],"product":"Copper-sensing transcription factor; involved in regulation of genes required for high affinity copper transport; required for regulation of yeast copper genes in response to DNA-damaging agents; undergoes changes in redox state in response to changing levels of copper or MMS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004623","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR021C"}


id: YMR022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04612":null,"YMR022W":null},"has_protein_features":false,"name":"UBC7","ortholog_annotations":[{"gene_uniquename":"YMR022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04612","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin conjugating enzyme; involved in the ER-associated protein degradation (ERAD) pathway and in the inner nuclear membrane-associated degradation (INMAD) pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004624","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR022W"}


id: YMR023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02302":null,"YMR023C":null},"has_protein_features":false,"name":"MSS1","ortholog_annotations":[{"gene_uniquename":"YMR023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02302","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein; forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004625","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR023C"}


id: YMR024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04019":null,"YMR024W":null},"has_protein_features":false,"name":"MRPL3","ortholog_annotations":[{"gene_uniquename":"YMR024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04019","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; located in close proximity to the polypeptide exit channel of the ribosome; mutations in human homolog MRPL44 cause childhood cardiomyopathy; human MRPL44 deficiency results in inefficient assembly of the mitochondrial ribosome, and in tissue-specific respiratory chain deficiency, manifesting as either Complex I+Complex IV or Complex IV deficiency, depending on a cell type","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR024W"}


id: YMR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSI1","product":"Subunit of the Cop9 signalosome; which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome","secondary_identifier":"SGD:S000004627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR025W"}


id: YMR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03324":null,"YMR026C":null},"has_protein_features":false,"name":"PEX12","ortholog_annotations":[{"gene_uniquename":"YMR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03324","reference_uniquename":"PMID:29761456"}],"product":"C3HC4-type RING-finger peroxin and E3 ubiquitin ligase; required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR026C"}


id: YMR027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04242":null,"YMR027W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YMR027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04242","reference_uniquename":"PMID:29761456"}],"product":"A metal-dependent phosphatase, part of the DUF89 protein family; dephosphorylates fructose-1-phosphate; human ortholog, C6orf211 is involved in response to DNA damage; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR027W"}


id: YMR028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04235":null,"YMR028W":null},"has_protein_features":false,"name":"TAP42","ortholog_annotations":[{"gene_uniquename":"YMR028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04235","reference_uniquename":"PMID:29761456"}],"product":"Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR028W"}


id: YMR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02514":null,"YMR029C":null},"has_protein_features":false,"name":"FAR8","ortholog_annotations":[{"gene_uniquename":"YMR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02514","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR029C"}


id: YMR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RSF1","product":"Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes","secondary_identifier":"SGD:S000004632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR030W"}


id: YMR030W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; mCherry fusion protein localizes to the cytosol","secondary_identifier":"SGD:S000028574","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR030W-A"}


id: YMR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04227":null,"YMR031C":null},"has_protein_features":false,"name":"EIS1","ortholog_annotations":[{"gene_uniquename":"YMR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04227","reference_uniquename":"PMID:29761456"}],"product":"Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog, YKL050C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004633","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR031C"}


id: YMR031W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C","secondary_identifier":"SGD:S000004634","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR031W-A"}


id: YMR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03596":null,"SJAG_04077":null,"YMR032W":null},"has_protein_features":false,"name":"HOF1","ortholog_annotations":[{"gene_uniquename":"YMR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03596","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04077","reference_uniquename":"PMID:29761456"}],"product":"F-BAR protein that regulates actin cytoskeleton organization; binds and bundles actin filaments, linking them to septins; required for cytokinesis, actin cable organization, and secretory vesicle trafficking; regulates actomyosin ring dynamics and septin localization; N-term. half controls cell size and actin cable levels, while the C-term. half controls actin cable organization, inhibiting Bnr1p-mediated actin nucleation; forms axial striations/pillars at the bud neck; phosphorylated by Dbf2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004635","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR032W"}


id: YMR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02869":null,"YMR033W":null},"has_protein_features":false,"name":"ARP9","ortholog_annotations":[{"gene_uniquename":"YMR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02869","reference_uniquename":"PMID:29761456"}],"product":"Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004636","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR033W"}


id: YMR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RCH1","product":"Negative regulator of cytosolic calcium homeostasis; localizes to the plasma membrane, concentrating at the bud neck during cell division; regulated by Crz1p through a CDRE promoter element; non-essential gene; putative transporter with sequence similarity to human SLC10A7; functional homolog of C. albicans RCH1","secondary_identifier":"SGD:S000004637","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR034C"}


id: YMR035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02809":null,"YMR035W":null},"has_protein_features":false,"name":"IMP2","ortholog_annotations":[{"gene_uniquename":"YMR035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02809","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits (Imp1p and Imp2p that differ in substrate specificity), and Som1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR035W"}


id: YMR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04332":null,"YMR036C":null},"has_protein_features":false,"name":"MIH1","ortholog_annotations":[{"gene_uniquename":"YMR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04332","reference_uniquename":"PMID:29761456"}],"product":"Protein tyrosine phosphatase; involved in cell cycle control and retrograde protein transport; regulates the phosphorylation state of Cdc28p; modulates phosphorylation of retromer component Vps26p; homolog of S. pombe cdc25","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004639","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR036C"}


id: YMR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03388":null,"YMR037C":null},"has_protein_features":false,"name":"MSN2","ortholog_annotations":[{"gene_uniquename":"YMR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03388","reference_uniquename":"PMID:29761456"}],"product":"Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes; light sensing pathway component that accumulates in the nucleus in response to blue light; relative distribution to nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004640","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR037C"}


id: YMR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04403":null,"YMR038C":null},"has_protein_features":false,"name":"CCS1","ortholog_annotations":[{"gene_uniquename":"YMR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04403","reference_uniquename":"PMID:29761456"}],"product":"Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within N-terminus is involved in insertion of copper into Sod1p under conditions of copper deprivation; required for regulation of yeast copper genes in response to DNA-damaging agents; protein abundance increases in response to DNA replication stress; human homolog CCS can complement yeast ccs1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004641","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR038C"}


id: YMR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01771":null,"YMR039C":null},"has_protein_features":false,"name":"SUB1","ortholog_annotations":[{"gene_uniquename":"YMR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01771","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional regulator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in nonhomologous end-joining (NHEJ) of ds breaks in plasmid DNA, but not chromosomal DNA; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; negatively regulates sporulation; protein abundance increases in response to DNA replication stress; functionally complemented by human SUB1 (PC4)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR039C"}


id: YMR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03244":null,"YMR040W":null},"has_protein_features":false,"name":"YET2","ortholog_annotations":[{"gene_uniquename":"YMR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03244","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function that may interact with ribosomes; based on co-purification experiments; homolog of human BAP31 protein; YET2 has a paralog, YET1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR040W"}


id: YMR041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ARA2","product":"NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase","secondary_identifier":"SGD:S000004644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR041C"}


id: YMR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00210":null,"SJAG_02218":null,"YMR042W":null},"has_protein_features":false,"name":"ARG80","ortholog_annotations":[{"gene_uniquename":"YMR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00210","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02218","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor involved in regulating arginine-responsive genes; acts with Arg81p and Arg82p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR042W"}


id: YMR043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00210":null,"SJAG_02218":null,"YMR043W":null},"has_protein_features":false,"name":"MCM1","ortholog_annotations":[{"gene_uniquename":"YMR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00210","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02218","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor; involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR043W"}


id: YMR044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IOC4","product":"Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing","secondary_identifier":"SGD:S000004647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR044W"}


id: YMR046W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR046W-A"}


id: YMR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03299":null,"YMR047C":null},"has_protein_features":false,"name":"NUP116","ortholog_annotations":[{"gene_uniquename":"YMR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03299","reference_uniquename":"PMID:26896847"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p); NUP116 has a paralog, NUP100, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004650","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR047C"}


id: YMR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03097":null,"YMR048W":null},"has_protein_features":false,"name":"CSM3","ortholog_annotations":[{"gene_uniquename":"YMR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03097","reference_uniquename":"PMID:29761456"}],"product":"Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR048W"}


id: YMR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02830":null,"YMR049C":null},"has_protein_features":false,"name":"ERB1","ortholog_annotations":[{"gene_uniquename":"YMR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02830","reference_uniquename":"PMID:29761456"}],"product":"Constituent of 66S pre-ribosomal particles; forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; binds RNA via its C-terminal domain; homologous to mammalian Bop1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR049C"}


id: YMR052C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR052C-A"}


id: YMR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FAR3","product":"Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR052W"}


id: YMR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STB2","product":"Protein that interacts with Sin3p in a two-hybrid assay; part of a large protein complex with Sin3p and Stb1p; STB2 has a paralog, STB6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR053C"}


id: YMR054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00516":null,"YMR054W":null},"has_protein_features":false,"name":"STV1","ortholog_annotations":[{"gene_uniquename":"YMR054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00516","reference_uniquename":"PMID:29761456"}],"product":"Subunit a of vacuolar-ATPase V0 domain; encodes one of two isoforms, located in both Golgi and endosomal V-ATPase complexes while VPH1 encodes second isoform and is located in vacuolar V-ATPase complexes; interaction with PI(4)P is required for efficient localization and function of Stv1-containing V-ATPases; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR054W"}


id: YMR055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01386":null,"YMR055C":null},"has_protein_features":false,"name":"BUB2","ortholog_annotations":[{"gene_uniquename":"YMR055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01386","reference_uniquename":"PMID:29761456"}],"product":"Mitotic exit network regulator; forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR055C"}


id: YMR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02050":null,"YMR056C":null},"has_protein_features":false,"name":"AAC1","ortholog_annotations":[{"gene_uniquename":"YMR056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02050","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR056C"}


id: YMR057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1","secondary_identifier":"SGD:S000004661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR057C"}


id: YMR058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04677":null,"YMR058W":null},"has_protein_features":false,"name":"FET3","ortholog_annotations":[{"gene_uniquename":"YMR058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04677","reference_uniquename":"PMID:29761456"}],"product":"Ferro-O2-oxidoreductase; multicopper oxidase that oxidizes ferrous (Fe2+) to ferric iron (Fe3+) for subsequent cellular uptake by transmembrane permease Ftr1p; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR058W"}


id: YMR059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04907":null,"YMR059W":null},"has_protein_features":false,"name":"SEN15","ortholog_annotations":[{"gene_uniquename":"YMR059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04907","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004663","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR059W"}


id: YMR060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02355":null,"YMR060C":null},"has_protein_features":false,"name":"SAM37","ortholog_annotations":[{"gene_uniquename":"YMR060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02355","reference_uniquename":"PMID:29761456"}],"product":"Component of the Sorting and Assembly Machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004664","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR060C"}


id: YMR061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03594":null,"YMR061W":null},"has_protein_features":false,"name":"RNA14","ortholog_annotations":[{"gene_uniquename":"YMR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03594","reference_uniquename":"PMID:29761456"}],"product":"Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004665","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR061W"}


id: YMR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01592":null,"YMR062C":null},"has_protein_features":false,"name":"ARG7","ortholog_annotations":[{"gene_uniquename":"YMR062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01592","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ornithine acetyltransferase; catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004666","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR062C"}


id: YMR063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01189":null,"SJAG_04058":null,"YMR063W":null},"has_protein_features":false,"name":"RIM9","ortholog_annotations":[{"gene_uniquename":"YMR063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01189","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04058","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004667","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR063W"}


id: YMR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AEP1","product":"Protein required for expression of the mitochondrial OLI1 gene; mitochondrial OLI1 gene encodes subunit 9 of F1-F0 ATP synthase","secondary_identifier":"SGD:S000004668","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR064W"}


id: YMR065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00810":null,"YMR065W":null},"has_protein_features":false,"name":"KAR5","ortholog_annotations":[{"gene_uniquename":"YMR065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00810","reference_uniquename":"PMID:29761456"}],"product":"Protein required for nuclear membrane fusion during karyogamy; localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; similar to zebrafish Brambleberry protein; expression of the gene is regulated by pheromone","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR065W"}


id: YMR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SOV1","product":"Translational activator involved in mitochondrial translation; role in mitochondrial ribosome assembly","secondary_identifier":"SGD:S000004670","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR066W"}


id: YMR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00490":null,"YMR067C":null},"has_protein_features":false,"name":"UBX4","ortholog_annotations":[{"gene_uniquename":"YMR067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00490","reference_uniquename":"PMID:29761456"}],"product":"UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the role of the Cdc48p-Nplp-Ufd1p AAA ATPase complex in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress; human ortholog ASPSCR1 partially complements the yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR067C"}


id: YMR068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AVO2","product":"Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; PM retention is dependent on Avo3p","secondary_identifier":"SGD:S000004672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR068W"}


id: YMR069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03537":null,"YMR069W":null},"has_protein_features":false,"name":"NAT4","ortholog_annotations":[{"gene_uniquename":"YMR069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03537","reference_uniquename":"PMID:29761456"}],"product":"N alpha-acetyl-transferase; involved in acetylation of the N-terminal residues of histones H4 and H2A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR069W"}


id: YMR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MOT3","product":"Transcriptional repressor, activator; role in cellular adjustment to osmotic stress including modulation of mating efficiency; involved in repression of subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of Tup1p-Cyc8p general repressor to promoters; relocalizes to cytosol under hypoxia; forms [MOT3+] prion under anaerobic conditions","secondary_identifier":"SGD:S000004674","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR070W"}


id: YMR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01206":null,"YMR071C":null},"has_protein_features":false,"name":"TVP18","ortholog_annotations":[{"gene_uniquename":"YMR071C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01206","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments; may have a role in intracellular sterol transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004675","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR071C"}


id: YMR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ABF2","product":"Mitochondrial DNA-binding and packaging factor; mtDNA maintenance factor involved in mitochondrial DNA replication and recombination, regulating mtDNA copy number in opposition to DPI34; HMG1 DNA-binding protein family member containing two HMG-boxes; activity may be regulated by protein kinase A phosphorylation; ABF2 has a paralog, IXR1, that arose from the whole genome duplication; human homolog TFAM can complement yeast abf2 mutant, rescuing the loss-of-mitochondrial DNA phenotype","secondary_identifier":"SGD:S000004676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR072W"}


id: YMR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02794":null,"YMR073C":null},"has_protein_features":false,"name":"IRC21","ortholog_annotations":[{"gene_uniquename":"YMR073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02794","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR073C"}


id: YMR074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02367":null,"YMR074C":null},"has_protein_features":false,"name":"SDD2","ortholog_annotations":[{"gene_uniquename":"YMR074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02367","reference_uniquename":"PMID:29761456"}],"product":"Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR074C"}


id: YMR075C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; almost completely overlaps verified ORF RCO1/YMR075W","secondary_identifier":"SGD:S000004679","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR075C-A"}


id: YMR075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01110":null,"SJAG_03884":null,"YMR075W":null},"has_protein_features":false,"name":"RCO1","ortholog_annotations":[{"gene_uniquename":"YMR075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01110","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03884","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the Rpd3S histone deacetylase complex; interacts with Eaf3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004680","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR075W"}


id: YMR076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04508":null,"YMR076C":null},"has_protein_features":false,"name":"PDS5","ortholog_annotations":[{"gene_uniquename":"YMR076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04508","reference_uniquename":"PMID:29761456"}],"product":"Cohesion maintenance factor; involved in sister chromatid condensation and cohesion; colocalizes with cohesin on chromosomes; performs its cohesin maintenance function in pre-anaphase cells by protecting the integrity of the cohesion complex; regulates homolog pairing and facilitates synaptonemal complex formation, axis formation, interhomolog recombination and synapsis during meiosis; relocalizes to the cytosol in response to hypoxia; scaffolding protein contains 26 HEAT repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004681","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR076C"}


id: YMR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00416":null,"YMR077C":null},"has_protein_features":false,"name":"VPS20","ortholog_annotations":[{"gene_uniquename":"YMR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00416","reference_uniquename":"PMID:29761456"}],"product":"Myristoylated subunit of the ESCRT-III complex; the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004682","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR077C"}


id: YMR078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02610":null,"YMR078C":null},"has_protein_features":false,"name":"CTF18","ortholog_annotations":[{"gene_uniquename":"YMR078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02610","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a complex with Ctf8p; shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004683","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR078C"}


id: YMR079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03746":null,"YMR079W":null},"has_protein_features":false,"name":"SEC14","ortholog_annotations":[{"gene_uniquename":"YMR079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03746","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs; SEC14 has a paralog, YKL091C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR079W"}


id: YMR080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03886":null,"YMR080C":null},"has_protein_features":false,"name":"NAM7","ortholog_annotations":[{"gene_uniquename":"YMR080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03886","reference_uniquename":"PMID:29761456"}],"product":"ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; binds to the small ribosomal subunit via an interaction with Rps26; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004685","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR080C"}


id: YMR081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ISF1","product":"Serine-rich, hydrophilic protein; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant; ISF1 has a paralog, MBR1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004686","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR081C"}


id: YMR082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YMR082C is not an essential gene","secondary_identifier":"SGD:S000004687","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR082C"}


id: YMR083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01414":null,"SJAG_03370":null,"YMR083W":null},"has_protein_features":false,"name":"ADH3","ortholog_annotations":[{"gene_uniquename":"YMR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01414","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03370","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004688","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR083W"}


id: YMR084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04728":null,"YMR084W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YMR084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04728","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004689","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR084W"}


id: YMR085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1","secondary_identifier":"SGD:S000004690","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR085W"}


id: YMR086C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004691","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR086C-A"}


id: YMR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02087":null,"YMR086W":null},"has_protein_features":false,"name":"SEG1","ortholog_annotations":[{"gene_uniquename":"YMR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02087","reference_uniquename":"PMID:29761456"}],"product":"Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation, controls eisosome length and shape; diffusely distributed, forms heterogeneous patches at plasma membrane in small buds, also found in medium and large buds; expression repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes; SEG1 has a paralog, SEG2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004692","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR086W"}


id: YMR087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PDL32","product":"Putative ADP-ribose-1''-monophosphatase; converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain","secondary_identifier":"SGD:S000004693","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR087W"}


id: YMR088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02029":null,"SJAG_04725":null,"YMR088C":null},"has_protein_features":false,"name":"VBA1","ortholog_annotations":[{"gene_uniquename":"YMR088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02029","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04725","reference_uniquename":"PMID:29761456"}],"product":"Permease of basic amino acids in vacuolar membrane; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004694","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR088C"}


id: YMR089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01179":null,"YMR089C":null},"has_protein_features":false,"name":"YTA12","ortholog_annotations":[{"gene_uniquename":"YMR089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01179","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; overexpression of human AFG3L2 complements respiratory defect of yeast afg3 yta12 double null mutation, but overexpression of disease-associated AFG3L2 variants does not; expression of both human SPG7 (paraplegin) and AFG3L2 complements yeast yta12 afg3 double mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004695","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR089C"}


id: YMR090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00366":null,"YMR090W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YMR090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00366","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; similar to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004696","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR090W"}


id: YMR091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03944":null,"YMR091C":null},"has_protein_features":false,"name":"NPL6","ortholog_annotations":[{"gene_uniquename":"YMR091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03944","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004697","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR091C"}


id: YMR092C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03380":null,"YMR092C":null},"has_protein_features":false,"name":"AIP1","ortholog_annotations":[{"gene_uniquename":"YMR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03380","reference_uniquename":"PMID:29761456"}],"product":"Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; inhibits elongation of aged ADP-actin filaments decorated with cofilin to maintain a high level of assembly-competent actin species; required to restrict cofilin localization to cortical patches; putative regulator of cytokinesis; contains WD repeats; mutations in human homolog WDR1 are associated with cardiac hypertrophy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004698","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR092C"}


id: YMR093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02608":null,"YMR093W":null},"has_protein_features":false,"name":"UTP15","ortholog_annotations":[{"gene_uniquename":"YMR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02608","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004699","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR093W"}


id: YMR094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CTF13","product":"Subunit of the CBF3 complex; F-box protein of the leucine-rich-repeat family; required for assembly of the complex; CBF3 binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis","secondary_identifier":"SGD:S000004700","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR094W"}


id: YMR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00691":null,"YMR095C":null},"has_protein_features":false,"name":"SNO1","ortholog_annotations":[{"gene_uniquename":"YMR095C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00691","reference_uniquename":"PMID:29761456"}],"product":"Protein of unconfirmed function; involved in pyridoxine metabolism; expression is induced during stationary phase; forms putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase; sno1-Δ affects abundance of mRNA from downstream gene CTF13","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004701","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR095C"}


id: YMR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00283":null,"YMR096W":null},"has_protein_features":false,"name":"SNZ1","ortholog_annotations":[{"gene_uniquename":"YMR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00283","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a two-component pyridoxal-5'-phosphate synthase; involved in pyridoxine (vitamin B6) biosynthesis from glyceraldehyde-3-phosphate, ribose-5-phosphate and ammonia liberated from glutamine by glutaminase; forms a complex with Sno1p that functions as an active glutaminase; member of a stationary phase-induced gene family where transcriptional induction occurs during the postdiauxic phase; co-regulated with SNO1; paralog of SNZ2 and SNZ3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004702","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR096W"}


id: YMR097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00659":null,"YMR097C":null},"has_protein_features":false,"name":"MTG1","ortholog_annotations":[{"gene_uniquename":"YMR097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00659","reference_uniquename":"PMID:29761456"}],"product":"Putative GTPase peripheral to the mitochondrial inner membrane; essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004703","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR097C"}


id: YMR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00797":null,"YMR098C":null},"has_protein_features":false,"name":"ATP25","ortholog_annotations":[{"gene_uniquename":"YMR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00797","reference_uniquename":"PMID:29761456"}],"product":"Protein that associates with mitochondrial ribosome; required for the stability of Oli1p (Atp9p) mRNA; also required for the Oli1p ring formation; YMR098C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR098C"}


id: YMR099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase); likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000004705","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR099C"}


id: YMR100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00910":null,"YMR100W":null},"has_protein_features":false,"name":"MUB1","ortholog_annotations":[{"gene_uniquename":"YMR100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00910","reference_uniquename":"PMID:29761456"}],"product":"MYND domain-containing protein; component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex, required for ubiquitination and degradation of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; proposed to function as both a partner and substrate of the Ubr2p/Rad6p ubiquitin ligase; similar to the A. nidulans samB gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004706","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR100W"}


id: YMR101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02163":null,"YMR101C":null},"has_protein_features":false,"name":"SRT1","ortholog_annotations":[{"gene_uniquename":"YMR101C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02163","reference_uniquename":"PMID:29761456"}],"product":"Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1; involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004707","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR101C"}


id: YMR102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01563":null,"SJAG_03432":null,"YMR102C":null},"has_protein_features":false,"name":"LAF1","ortholog_annotations":[{"gene_uniquename":"YMR102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01563","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03432","reference_uniquename":"PMID:29761456"}],"product":"Sterol-binding beta-propeller protein; physically associates with sterol-binding StARkin domain-containing proteins Ysp2/Lam2/Ltc4 and Lam4/Ltc3; essential for retrograde transport of ergosterol from the plasma membrane to the endoplasmic reticulum at ER-PM contact sites; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; non-essential gene; has a paralog, DGR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004708","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR102C"}


id: YMR103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YMR103C is not an essential gene","secondary_identifier":"SGD:S000004709","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR103C"}


id: YMR104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04206":null,"YMR104C":null},"has_protein_features":false,"name":"YPK2","ortholog_annotations":[{"gene_uniquename":"YMR104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04206","reference_uniquename":"PMID:29761456"}],"product":"AGC-type S/T protein kinase; participates in the cell wall integrity signaling pathway; involved with Ypk1p in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6), and in the direct phosphorylation of the Myo5p motor domain TEDS site; phosphorylated and activated by Pkh1/2p in the presence of phytosphingosine; direct phosphorylation by Tor2p regulates actin polarization; genetically redundant with YPK1; human homolog SGK2 can complement the inviability of a ypk1 ypk2 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004710","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR104C"}


id: YMR105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01209":null,"YMR105C":null},"has_protein_features":false,"name":"PGM2","ortholog_annotations":[{"gene_uniquename":"YMR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01209","reference_uniquename":"PMID:29761456"}],"product":"Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress; PGM2 has a paralog, PGM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004711","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR105C"}


id: YMR105W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028692","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR105W-A"}


id: YMR106C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04372":null,"YMR106C":null},"has_protein_features":false,"name":"YKU80","ortholog_annotations":[{"gene_uniquename":"YMR106C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04372","reference_uniquename":"PMID:29761456"}],"product":"Subunit of telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein via interaction with TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair; colocalizes with quiescent cell telomere hyperclusters","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004712","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR106C"}


id: YMR106W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; may have been brought into S. cerevisiae genome via horizontal transfer mediated by Ty1 retrotransposition","secondary_identifier":"SGD:S000350097","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR106W-A"}


id: YMR107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPG4","product":"Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources","secondary_identifier":"SGD:S000004713","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR107W"}


id: YMR108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03985":null,"YMR108W":null},"has_protein_features":false,"name":"ILV2","ortholog_annotations":[{"gene_uniquename":"YMR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03985","reference_uniquename":"PMID:29761456"}],"product":"Acetolactate synthase; catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004714","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR108W"}


id: YMR109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04001":null,"YMR109W":null},"has_protein_features":false,"name":"MYO5","ortholog_annotations":[{"gene_uniquename":"YMR109W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04001","reference_uniquename":"PMID:29761456"}],"product":"One of two type I myosin motors; involved in clathrin-mediated endocytosis; activation by TEDS site phosphorylation increases actin gliding, motor activity and ligand-induced endocytosis; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO5 has a paralog, MYO3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004715","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR109W"}


id: YMR110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HFD1","product":"Dehydrogenase involved in ubiquinone and sphingolipid metabolism; converts 4-hydroxybenzaldehyde into 4-hydroxybenzoate for ubiquinone anabolism, hexadecenal to hexadecenoic acid in sphingosine 1-phosphate catabolism; human homolog ALDH3A2, mutated in Sjogren-Larsson syndrome, can rescue yeast hfd1 mutant; human ALDH3A1, but not ALDH3A2, rescues pABA- respiratory growth phenotype of hfd1 null; data suggest that dual functions of Hfd1p have diverged in human ALDH3A1, ALDH3A2","secondary_identifier":"SGD:S000004716","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR110C"}


id: YMR111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EUC1","product":"Sequence-specific DNA binding protein; binds to a sequence motif associated with distinct genomic hotspots of non-H2B protein ubiquitylation (ub-hotspots); interacts with Slx5p to recruit the Slx5-Slx8  SUMO-targeted Ub ligase (STUbL) complex to ub-hotspots; deletion prevents ub-hotspot formation and exacerbates heat sensitivity of cells deficient in Rpd3L histone deacetylase complex members; forms nuclear foci upon DNA replication stress","secondary_identifier":"SGD:S000004717","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR111C"}


id: YMR112C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01403":null,"YMR112C":null},"has_protein_features":false,"name":"MED11","ortholog_annotations":[{"gene_uniquename":"YMR112C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01403","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004718","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR112C"}


id: YMR113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00529":null,"YMR113W":null},"has_protein_features":false,"name":"FOL3","ortholog_annotations":[{"gene_uniquename":"YMR113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00529","reference_uniquename":"PMID:29761456"}],"product":"Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis; FOL3 has a paralog, RMA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004719","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR113W"}


id: YMR114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene","secondary_identifier":"SGD:S000004720","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR114C"}


id: YMR115W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00354":null,"YMR115W":null},"has_protein_features":false,"name":"MGR3","ortholog_annotations":[{"gene_uniquename":"YMR115W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00354","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004721","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR115W"}


id: YMR116C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05000":null,"YMR116C":null},"has_protein_features":false,"name":"ASC1","ortholog_annotations":[{"gene_uniquename":"YMR116C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05000","reference_uniquename":"PMID:29761456"}],"product":"G-protein beta subunit and guanine dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; required to prevent frameshifting at ribosomes stalled at repeated CGA codons; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation; controls phosphorylation of multiple proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004722","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR116C"}


id: YMR117C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02814":null,"YMR117C":null},"has_protein_features":false,"name":"SPC24","ortholog_annotations":[{"gene_uniquename":"YMR117C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02814","reference_uniquename":"PMID:29761456"}],"product":"Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004723","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR117C"}


id: YMR118C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03920":null,"YMR118C":null},"has_protein_features":false,"name":"SHH3","ortholog_annotations":[{"gene_uniquename":"YMR118C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03920","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial inner membrane protein of unknown function; although similar to paralogous Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase; SHH3 has a paralog, SDH3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR118C"}


id: YMR119W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ASI1","product":"Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; the Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and regulators of sterol biosynthesis for ubiquitin-mediated degradation; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids","secondary_identifier":"SGD:S000004725","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR119W"}


id: YMR119W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of ORF ASI1/YMR119W","secondary_identifier":"SGD:S000004726","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR119W-A"}


id: YMR120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04681":null,"YMR120C":null},"has_protein_features":false,"name":"ADE17","ortholog_annotations":[{"gene_uniquename":"YMR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04681","reference_uniquename":"PMID:29761456"}],"product":"Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004727","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR120C"}


id: YMR121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03919":null,"SJAG_04478":null,"YMR121C":null},"has_protein_features":false,"name":"RPL15B","ortholog_annotations":[{"gene_uniquename":"YMR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03919","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04478","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004728","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR121C"}


id: YMR122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YMR122C is not an essential gene","secondary_identifier":"SGD:S000004729","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR122C"}


id: YMR122W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NCW1","product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum","secondary_identifier":"SGD:S000007524","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR122W-A"}


id: YMR123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05306":null,"YMR123W":null},"has_protein_features":false,"name":"PKR1","ortholog_annotations":[{"gene_uniquename":"YMR123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05306","reference_uniquename":"PMID:29761456"}],"product":"V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004730","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR123W"}


id: YMR124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EPO1","product":"Protein involved in septin-ER tethering; interacts with ER membrane protein, Scs2p, and Shs1p, a septin ring component, at bud neck to create ER diffusion barrier; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W has a paralog, YLR031W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004731","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR124W"}


id: YMR125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04360":null,"YMR125W":null},"has_protein_features":false,"name":"STO1","ortholog_annotations":[{"gene_uniquename":"YMR125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04360","reference_uniquename":"PMID:29761456"}],"product":"Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004732","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR125W"}


id: YMR126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DLT1","product":"Protein of unknown function; mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)","secondary_identifier":"SGD:S000004733","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR126C"}


id: YMR127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SAS2","product":"Histone acetyltransferase (HAT) catalytic subunit of the SAS complex; acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family; other members are Sas4p and Sas5p","secondary_identifier":"SGD:S000004734","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR127C"}


id: YMR128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03077":null,"YMR128W":null},"has_protein_features":false,"name":"ECM16","ortholog_annotations":[{"gene_uniquename":"YMR128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03077","reference_uniquename":"PMID:29761456"}],"product":"Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; functions with methyltransferase Bud23p; predominantly nucleolar in distribution; required for 18S rRNA synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004735","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR128W"}


id: YMR129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01834":null,"YMR129W":null},"has_protein_features":false,"name":"POM152","ortholog_annotations":[{"gene_uniquename":"YMR129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01834","reference_uniquename":"PMID:29761456"}],"product":"Glycoprotein subunit of transmembrane ring of nuclear pore complex; contributes to nucleocytoplasmic transport, nuclear pore complex (NPC) biogenesis and spindle pole body duplication; type II transmembrane protein composed of N-terminal cytosolic and C-terminal nuclear envelope lumenal domains; homologous to human NUP210","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004736","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR129W"}


id: YMR130W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04501":null,"YMR130W":null},"has_protein_features":false,"name":"DPI35","ortholog_annotations":[{"gene_uniquename":"YMR130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04501","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial protein of unknown function; DPI35 is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004737","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR130W"}


id: YMR131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01122":null,"YMR131C":null},"has_protein_features":false,"name":"RRB1","ortholog_annotations":[{"gene_uniquename":"YMR131C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01122","reference_uniquename":"PMID:29761456"}],"product":"Specific assembly chaperone for ribosomal protein Rpl3p; co-translationally associates with nascent Rpl3p, preventing aggregation, and facilitating nuclear import; required for biogenesis of preribosomal particles; essential gene; contains five WD-repeat motifs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004738","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR131C"}


id: YMR132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01390":null,"YMR132C":null},"has_protein_features":false,"name":"JLP2","ortholog_annotations":[{"gene_uniquename":"YMR132C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01390","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function; contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004739","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR132C"}


id: YMR133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07002":null,"YMR133W":null},"has_protein_features":false,"name":"REC114","ortholog_annotations":[{"gene_uniquename":"YMR133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07002","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004740","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR133W"}


id: YMR134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ERG29","product":"Protein of unknown function involved in ergosterol biosynthesis; conditional mutants produce less ergosterol, display impaired oxygen consumption, respiratory growth, mitochondrial iron utilization, and are more sensitive to oxidative stress; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; protein localizes to the cytoplasm, ER and nuclear envelope; highly conserved in ascomycetes","secondary_identifier":"SGD:S000004741","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR134W"}


id: YMR135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01886":null,"YMR135C":null},"has_protein_features":false,"name":"GID8","ortholog_annotations":[{"gene_uniquename":"YMR135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01886","reference_uniquename":"PMID:29761456"}],"product":"Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004742","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR135C"}


id: YMR135W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004743","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR135W-A"}


id: YMR136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GAT2","product":"Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine","secondary_identifier":"SGD:S000004744","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR136W"}


id: YMR137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03734":null,"YMR137C":null},"has_protein_features":false,"name":"PSO2","ortholog_annotations":[{"gene_uniquename":"YMR137C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03734","reference_uniquename":"PMID:29761456"}],"product":"Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress; translocates to mitochondria under genotoxic agents","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004745","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR137C"}


id: YMR138W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00983":null,"YMR138W":null},"has_protein_features":false,"name":"CIN4","ortholog_annotations":[{"gene_uniquename":"YMR138W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00983","reference_uniquename":"PMID:29761456"}],"product":"GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004746","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR138W"}


id: YMR139W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00718":null,"SJAG_05304":null,"YMR139W":null},"has_protein_features":false,"name":"RIM11","ortholog_annotations":[{"gene_uniquename":"YMR139W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00718","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR139W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05304","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004747","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR139W"}


id: YMR140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02603":null,"YMR140W":null},"has_protein_features":false,"name":"SIP5","ortholog_annotations":[{"gene_uniquename":"YMR140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02603","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004748","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR140W"}


id: YMR141C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YMR141C is not an essential gene","secondary_identifier":"SGD:S000004749","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR141C"}


id: YMR141W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene RPL13B/YMR142C","secondary_identifier":"SGD:S000028575","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR141W-A"}


id: YMR142C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01608":null,"SJAG_03423":null,"YMR142C":null},"has_protein_features":false,"name":"RPL13B","ortholog_annotations":[{"gene_uniquename":"YMR142C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR142C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03423","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004750","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR142C"}


id: YMR143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01609":null,"SJAG_03422":null,"YMR143W":null},"has_protein_features":false,"name":"RPS16A","ortholog_annotations":[{"gene_uniquename":"YMR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01609","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YMR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03422","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004751","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR143W"}


id: YMR144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FDO1","product":"Protein involved in directionality of mating type switching; acts with Fkh1p to control which donor mating-type locus is inserted into MAT locus during mating type switching; localized to the nucleus; not an essential gene","secondary_identifier":"SGD:S000004752","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR144W"}


id: YMR145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01539":null,"YMR145C":null},"has_protein_features":false,"name":"NDE1","ortholog_annotations":[{"gene_uniquename":"YMR145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01539","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial external NADH dehydrogenase; type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain; NDE1 has a paralog, NDE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004753","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR145C"}


id: YMR146C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02164":null,"YMR146C":null},"has_protein_features":false,"name":"TIF34","ortholog_annotations":[{"gene_uniquename":"YMR146C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02164","reference_uniquename":"PMID:29761456"}],"product":"eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; stimulates rate of ribosomal scanning during translation reinitiation; eIF3 is also involved in programmed stop codon readthrough","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004754","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR146C"}


id: YMR147W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LDO45","product":"Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery","secondary_identifier":"SGD:S000004755","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR147W"}


id: YMR148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LDO16","product":"Protein of unknown function with possible role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion","secondary_identifier":"SGD:S000004756","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR148W"}


id: YMR149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04090":null,"YMR149W":null},"has_protein_features":false,"name":"SWP1","ortholog_annotations":[{"gene_uniquename":"YMR149W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04090","reference_uniquename":"PMID:29761456"}],"product":"Delta subunit of the oligosaccharyl transferase glycoprotein complex; complex is required for N-linked glycosylation of proteins in the endoplasmic reticulum","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004757","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR149W"}


id: YMR150C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03648":null,"YMR150C":null},"has_protein_features":false,"name":"IMP1","ortholog_annotations":[{"gene_uniquename":"YMR150C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03648","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits (Imp1p and Imp2p that differ in substrate specificty) and Som1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004758","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR150C"}


id: YMR151W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YIM2","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1","secondary_identifier":"SGD:S000004759","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR151W"}


id: YMR152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04376":null,"YMR152W":null},"has_protein_features":false,"name":"YIM1","ortholog_annotations":[{"gene_uniquename":"YMR152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04376","reference_uniquename":"PMID:29761456"}],"product":"Aldehyde reductase; involved in detoxification of lignocellulose-derived aldehydes; catalyzes the reduction of furan, aliphatic and aromatic aldehydes using either NADH or NADPH as co-factor; membrane of the quinone oxidoreductase subfamily of the medium-chain dehydrogenase/reductase family; null mutant displays sensitivity to DNA damaging agents; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004760","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR152W"}


id: YMR153C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps 3' end of verified gene NUP53/YMR153W","secondary_identifier":"SGD:S000004761","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR153C-A"}


id: YMR153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03593":null,"YMR153W":null},"has_protein_features":false,"name":"NUP53","ortholog_annotations":[{"gene_uniquename":"YMR153W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03593","reference_uniquename":"PMID:29761456"}],"product":"FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004762","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR153W"}


id: YMR154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RIM13","product":"Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB","secondary_identifier":"SGD:S000004763","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR154C"}


id: YMR155W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen","secondary_identifier":"SGD:S000004764","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR155W"}


id: YMR156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02680":null,"YMR156C":null},"has_protein_features":false,"name":"TPP1","ortholog_annotations":[{"gene_uniquename":"YMR156C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02680","reference_uniquename":"PMID:29761456"}],"product":"DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3'-phosphatase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004765","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR156C"}


id: YMR157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM36","product":"Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000004766","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR157C"}


id: YMR158C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; may contain a lipid attachment site; localizes to cytosol, and to peroxisomes in oleate-growing cells; YMR158C-A is not an essential gene","secondary_identifier":"SGD:S000007249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR158C-A"}


id: YMR158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05320":null,"YMR158W":null},"has_protein_features":false,"name":"MRPS8","ortholog_annotations":[{"gene_uniquename":"YMR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05320","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004767","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR158W"}


id: YMR158W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C","secondary_identifier":"SGD:S000004768","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR158W-B"}


id: YMR159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03136":null,"YMR159C":null},"has_protein_features":false,"name":"ATG16","ortholog_annotations":[{"gene_uniquename":"YMR159C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03136","reference_uniquename":"PMID:29761456"}],"product":"Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which binds to membranes and localizes to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004769","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR159C"}


id: YMR160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CVM1","product":"Protein involved in sphingolipid metabolism; localizes to vacuolar contact sites with mitochondria, ER and peroxisomes; mutant has enhanced sensitivity to overexpression of mutant huntingtin; relative distribution within the vacuolar membrane changes upon DNA replication stress","secondary_identifier":"SGD:S000004770","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR160W"}


id: YMR161W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01160":null,"YMR161W":null},"has_protein_features":false,"name":"HLJ1","ortholog_annotations":[{"gene_uniquename":"YMR161W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01160","reference_uniquename":"PMID:26896847"}],"product":"Co-chaperone for Hsp40p; anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000004771","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR161W"}


id: YMR162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00669":null,"YMR162C":null},"has_protein_features":false,"name":"DNF3","ortholog_annotations":[{"gene_uniquename":"YMR162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00669","reference_uniquename":"PMID:29761456"}],"product":"Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004772","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR162C"}


id: YMR163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04315":null,"YMR163C":null},"has_protein_features":false,"name":"INP2","ortholog_annotations":[{"gene_uniquename":"YMR163C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04315","reference_uniquename":"PMID:29761456"}],"product":"Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004773","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR163C"}


id: YMR164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MSS11","product":"Transcription factor; involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals; forms a heterodimer with Flo8p that interacts with the Swi/Snf complex during transcriptional activation of FLO1, FLO11, and STA1","secondary_identifier":"SGD:S000004774","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR164C"}


id: YMR165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02763":null,"YMR165C":null},"has_protein_features":false,"name":"PAH1","ortholog_annotations":[{"gene_uniquename":"YMR165C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02763","reference_uniquename":"PMID:29761456"}],"product":"Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; regulates phospholipid synthesis, nuclear/ER membrane growth, lipid droplet formation, triacylglycerol synthesis, vacuolar homeostasis and cell wall integrity; phosphorylated by Pho85p/Pho80p, Cdc28p/Cyclin B, PKA, PKC, and CKII, regulating activity, localization, and proteosomal degradation; homolog of mammalian lipins 1 and 2; human homologs LPIN1, LPIN2, LPIN3 complement the null","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004775","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR165C"}


id: YMR166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02484":null,"YMR166C":null},"has_protein_features":false,"name":"MME1","ortholog_annotations":[{"gene_uniquename":"YMR166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02484","reference_uniquename":"PMID:29761456"}],"product":"Transporter of the mitochondrial inner membrane that exports magnesium; involved in mitochondrial Mg2+ homeostasis; has similarity to human mitochondrial ATP-Mg/Pi carriers","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004776","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR166C"}


id: YMR167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01620":null,"YMR167W":null},"has_protein_features":false,"name":"MLH1","ortholog_annotations":[{"gene_uniquename":"YMR167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01620","reference_uniquename":"PMID:29761456"}],"product":"Protein required for mismatch repair in mitosis and meiosis; also required for crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; required for silencing at the silent mating-type loci and telomeres; human homolog is associated with hereditary non-polyposis colon cancer","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004777","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR167W"}


id: YMR168C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CEP3","product":"Essential kinetochore protein; component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain","secondary_identifier":"SGD:S000004778","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR168C"}


id: YMR169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ALD3","product":"Cytoplasmic aldehyde dehydrogenase; involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose","secondary_identifier":"SGD:S000004779","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR169C"}


id: YMR170C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ALD2","product":"Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p","secondary_identifier":"SGD:S000004780","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR170C"}


id: YMR171C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01586":null,"YMR171C":null},"has_protein_features":false,"name":"EAR1","ortholog_annotations":[{"gene_uniquename":"YMR171C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01586","reference_uniquename":"PMID:29761456"}],"product":"Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004781","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR171C"}


id: YMR172C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps 3' end of ORF HOT1/YMR172W","secondary_identifier":"SGD:S000004782","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR172C-A"}


id: YMR172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HOT1","product":"Transcription factor for glycerol biosynthetic genes; required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p","secondary_identifier":"SGD:S000004783","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR172W"}


id: YMR173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02442":null,"YMR173W":null},"has_protein_features":false,"name":"DDR48","ortholog_annotations":[{"gene_uniquename":"YMR173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02442","reference_uniquename":"PMID:29761456"}],"product":"DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR173W"}


id: YMR173W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W","secondary_identifier":"SGD:S000004785","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR173W-A"}


id: YMR174C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAI3","product":"Cytoplasmic proteinase A (Pep4p) inhibitor; dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact","secondary_identifier":"SGD:S000004786","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR174C"}


id: YMR175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SIP18","product":"Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress; SIP18 has a paralog, GRE1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004787","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR175W"}


id: YMR175W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028848","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR175W-A"}


id: YMR176W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01465":null,"SJAG_03635":null,"YMR176W":null},"has_protein_features":false,"name":"ECM5","ortholog_annotations":[{"gene_uniquename":"YMR176W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01465","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YMR176W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03635","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Snt2C complex; physically associates with Snt2p and Rpd3p; along with Snt2p, recruits Rpd3p to a small number of promoters; also colocalizes with Snt2p, independently of Rpd3p, to promoters of stress response genes in response to oxidative stress; contains ATP/GTP-binding site motif A; null mutant exhibits increased cellular volume, large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004788","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR176W"}


id: YMR177W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04260":null,"YMR177W":null},"has_protein_features":false,"name":"MMT1","ortholog_annotations":[{"gene_uniquename":"YMR177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04260","reference_uniquename":"PMID:29761456"}],"product":"Putative metal transporter involved in mitochondrial iron accumulation; MMT1 has a paralog, MMT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004789","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR177W"}


id: YMR178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FPY1","product":"FAD pyrophosphatase; hydrolyzes FAD as the preferred substrate but also acts on NADH and ADP-ribose at lower rates; activity is dependent upon K+ and divalent metal cations; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; FPY1 is not an essential gene; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004790","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR178W"}


id: YMR179W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03183":null,"YMR179W":null},"has_protein_features":false,"name":"SPT21","ortholog_annotations":[{"gene_uniquename":"YMR179W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03183","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; binds with Spt10p to histone gene promoters during S phase; localizes to nuclear foci that become diffuse upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004791","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR179W"}


id: YMR180C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04488":null,"YMR180C":null},"has_protein_features":false,"name":"CTL1","ortholog_annotations":[{"gene_uniquename":"YMR180C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04488","reference_uniquename":"PMID:29761456"}],"product":"RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm; CTL1 has a paralog, CET1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004792","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR180C"}


id: YMR181C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004793","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR181C"}


id: YMR182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RGM1","product":"Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y' telomeric elements and subtelomeric COS genes; relocalizes to the cytosol in response to hypoxia; RGM1 has a paralog, USV1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004794","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR182C"}


id: YMR182W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIN3","product":"Mitochondrial protein of unknown function","secondary_identifier":"SGD:S000028693","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR182W-A"}


id: YMR183C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03536":null,"YMR183C":null},"has_protein_features":false,"name":"SSO2","ortholog_annotations":[{"gene_uniquename":"YMR183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03536","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p; SSO2 has a paralog, SSO1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004795","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR183C"}


id: YMR184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ADD37","product":"Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004796","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR184W"}


id: YMR185W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01328":null,"YMR185W":null},"has_protein_features":false,"name":"RTP1","ortholog_annotations":[{"gene_uniquename":"YMR185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01328","reference_uniquename":"PMID:29761456"}],"product":"Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004797","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR185W"}


id: YMR186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01664":null,"YMR186W":null},"has_protein_features":false,"name":"HSC82","ortholog_annotations":[{"gene_uniquename":"YMR186W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01664","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic chaperone of the Hsp90 family; plays a role in determining prion variants; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004798","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR186W"}


id: YMR187C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01212":null,"YMR187C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YMR187C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01212","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; YMR187C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004799","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR187C"}


id: YMR188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02359":null,"YMR188C":null},"has_protein_features":false,"name":"MRPS17","ortholog_annotations":[{"gene_uniquename":"YMR188C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02359","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004800","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR188C"}


id: YMR189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03861":null,"YMR189W":null},"has_protein_features":false,"name":"GCV2","ortholog_annotations":[{"gene_uniquename":"YMR189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03861","reference_uniquename":"PMID:29761456"}],"product":"P subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004801","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR189W"}


id: YMR190C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03898":null,"YMR190C":null},"has_protein_features":false,"name":"SGS1","ortholog_annotations":[{"gene_uniquename":"YMR190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03898","reference_uniquename":"PMID:29761456"}],"product":"RecQ family nucleolar DNA helicase; role in genome integrity maintenance, chromosome synapsis, meiotic joint molecule/crossover formation; stimulates activity of Top3p; rapidly lost in response to rapamycin in Rrd1p-dependent manner; forms nuclear foci upon DNA replication stress; yeast SGS1 complements mutations in human homolog BLM implicated in Bloom syndrome; also similar to human WRN implicated in Werner syndrome; human BLM and WRN can each complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004802","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YMR190C"}


