# genes

id: YBR164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ARL1","product":"Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; role in membrane organization at trans-Golgi network; required for delivery of Atg9p to the phagophore assembly site during autophagy under high temperature stress; required with Ypt6p for starvation-induced autophagy; required for the CVT pathway under non-starvation conditions; G protein of the Ras superfamily, similar to ADP-ribosylation factor","secondary_identifier":"SGD:S000000368","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR164C"}


id: YBR165W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UBS1","product":"Ubiquitin-conjugating enzyme suppressor that regulates Cdc34p; functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity","secondary_identifier":"SGD:S000000369","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR165W"}


id: YBR166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04652":null,"YBR166C":null},"has_protein_features":false,"name":"TYR1","ortholog_annotations":[{"gene_uniquename":"YBR166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04652","reference_uniquename":"PMID:29761456"}],"product":"Prephenate dehydrogenase involved in tyrosine biosynthesis; expression is dependent on phenylalanine levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000370","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR166C"}


id: YBR167C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01369":null,"SJAG_06613":null,"YBR167C":null},"has_protein_features":false,"name":"POP7","ortholog_annotations":[{"gene_uniquename":"YBR167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01369","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06613","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop6p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000371","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR167C"}


id: YBR168W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01685":null,"YBR168W":null},"has_protein_features":false,"name":"PEX32","ortholog_annotations":[{"gene_uniquename":"YBR168W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01685","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000372","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR168W"}


id: YBR169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04511":null,"YBR169C":null},"has_protein_features":false,"name":"SSE2","ortholog_annotations":[{"gene_uniquename":"YBR169C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04511","reference_uniquename":"PMID:29761456"}],"product":"Member of Hsp110 subclass of the heat shock protein 70 (HSP70) family; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000373","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR169C"}


id: YBR170C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01134":null,"YBR170C":null},"has_protein_features":false,"name":"NPL4","ortholog_annotations":[{"gene_uniquename":"YBR170C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01134","reference_uniquename":"PMID:29761456"}],"product":"Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; K48-specific Ub chain binding receptor that assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates destined for proteasomal degradation; role in regulated destruction of ER membrane proteins, like HMG-CoA reductase (Hmg1/2p), cytosolic proteins (Fbp1p) and mislocalized proteins (Cse4p); mobilizes membrane-bound transcription factors by regulated Ub/proteasome-dependent processing; contains a UBX domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000374","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR170C"}


id: YBR171W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02354":null,"YBR171W":null},"has_protein_features":false,"name":"SEC66","ortholog_annotations":[{"gene_uniquename":"YBR171W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02354","reference_uniquename":"PMID:29761456"}],"product":"Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and translocation into the ER; other members are Sec63p, Sec62p, and Sec72p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000375","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR171W"}


id: YBR172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01279":null,"YBR172C":null},"has_protein_features":false,"name":"SMY2","ortholog_annotations":[{"gene_uniquename":"YBR172C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01279","reference_uniquename":"PMID:29761456"}],"product":"GYF domain protein; involved in COPII vesicle formation; regulates Cdc48p function in transcription stress response; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; homologous to human GIGYF1 and GIGYF2; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000376","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR172C"}


id: YBR173C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04290":null,"YBR173C":null},"has_protein_features":false,"name":"UMP1","ortholog_annotations":[{"gene_uniquename":"YBR173C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04290","reference_uniquename":"PMID:29761456"}],"product":"Chaperone required for correct maturation of the 20S proteasome; short-lived chaperone; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000377","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR173C"}


id: YBR174C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective","secondary_identifier":"SGD:S000000378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR174C"}


id: YBR175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02329":null,"YBR175W":null},"has_protein_features":false,"name":"SWD3","ortholog_annotations":[{"gene_uniquename":"YBR175W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02329","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR175W"}


id: YBR176W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05200":null,"YBR176W":null},"has_protein_features":false,"name":"ECM31","ortholog_annotations":[{"gene_uniquename":"YBR176W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05200","reference_uniquename":"PMID:29761456"}],"product":"Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR176W"}


id: YBR177C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EHT1","product":"Octanoyl-CoA:ethanol acyltransferase; also functions as thioesterase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR177C"}


id: YBR178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C","secondary_identifier":"SGD:S000000382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR178W"}


id: YBR179C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00031":null,"YBR179C":null},"has_protein_features":false,"name":"FZO1","ortholog_annotations":[{"gene_uniquename":"YBR179C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00031","reference_uniquename":"PMID:29761456"}],"product":"Mitofusin, protein involved in mitochondrial outer membrane fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system; activity regulated by ubiquitylation at conserved lysine residues and by  deubiquitylases Ubp2p and Ubp12p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000383","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR179C"}


id: YBR180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DTR1","product":"Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; sequence similarity to QDR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expressed during sporulation","secondary_identifier":"SGD:S000000384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR180W"}


id: YBR181C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03034":null,"SJAG_03859":null,"YBR181C":null},"has_protein_features":false,"name":"RPS6B","ortholog_annotations":[{"gene_uniquename":"YBR181C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR181C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03859","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR181C"}


id: YBR182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02218":null,"SJAG_04191":null,"YBR182C":null},"has_protein_features":false,"name":"SMP1","ortholog_annotations":[{"gene_uniquename":"YBR182C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02218","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YBR182C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04191","reference_uniquename":"PMID:29761456"}],"product":"MADS-box transcription factor involved in osmotic stress response; SMP1 has a paralog, RLM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR182C"}


id: YBR182C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028603","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR182C-A"}


id: YBR183W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YPC1","product":"Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR183W"}


id: YBR184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YBR184W is not an essential gene","secondary_identifier":"SGD:S000000388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR184W"}


id: YBR185C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01917":null,"YBR185C":null},"has_protein_features":false,"name":"MBA1","ortholog_annotations":[{"gene_uniquename":"YBR185C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01917","reference_uniquename":"PMID:29761456"}],"product":"Membrane-associated mitoribosome receptor; involved along with Dpi29p in the cotranslational insertion of nascent polypeptide chains into the inner mitochondrial membrane; associates with nascent polypeptide chains; interacts with Mdm38p and may recruit mRNA-specific translational activators to the mitoribosome; null mutant displays decreased tolerance to mistranslation-induced proteotoxic stress; localizes to the inner mitochondrial membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR185C"}


id: YBR186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PCH2","product":"Hexameric ring ATPase that remodels chromosome axis protein Hop1p; nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in rDNA; required for meiotic double-stranded break formation","secondary_identifier":"SGD:S000000390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR186W"}


id: YBR187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04096":null,"YBR187W":null},"has_protein_features":false,"name":"GDT1","ortholog_annotations":[{"gene_uniquename":"YBR187W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04096","reference_uniquename":"PMID:29761456"}],"product":"Calcium and manganese transporter with higher affinity for Ca2+; involved in Ca2+ and Mn2+ homeostasis; localizes to the cis- and medial-Golgi apparatus; GFP-fusion localizes to the vacuole; required for the Mn2+-dependent function of glycosylation enzymes; TMEM165, a human ortholog linked to Congenital Disorders of Glycosylation, functionally complements the null allele; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; expression regulated by Gcr1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR187W"}


id: YBR188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NTC20","product":"Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs","secondary_identifier":"SGD:S000000392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR188C"}


id: YBR189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00544":null,"SJAG_04342":null,"YBR189W":null},"has_protein_features":false,"name":"RPS9B","ortholog_annotations":[{"gene_uniquename":"YBR189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00544","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04342","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR189W"}


id: YBR190W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W","secondary_identifier":"SGD:S000000394","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR190W"}


id: YBR191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00155":null,"SJAG_01202":null,"YBR191W":null},"has_protein_features":false,"name":"RPL21A","ortholog_annotations":[{"gene_uniquename":"YBR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00155","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01202","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000395","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR191W"}


id: YBR191W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007594","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR191W-A"}


id: YBR192W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00154":null,"YBR192W":null},"has_protein_features":false,"name":"RIM2","ortholog_annotations":[{"gene_uniquename":"YBR192W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00154","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000396","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR192W"}


id: YBR193C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03622":null,"YBR193C":null},"has_protein_features":false,"name":"MED8","ortholog_annotations":[{"gene_uniquename":"YBR193C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03622","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000397","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR193C"}


id: YBR194W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00363":null,"YBR194W":null},"has_protein_features":false,"name":"AIM4","ortholog_annotations":[{"gene_uniquename":"YBR194W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00363","reference_uniquename":"PMID:29761456"}],"product":"Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000398","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR194W"}


id: YBR195C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01122":null,"SJAG_02439":null,"YBR195C":null},"has_protein_features":false,"name":"MSI1","ortholog_annotations":[{"gene_uniquename":"YBR195C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01122","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YBR195C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02439","reference_uniquename":"PMID:29761456"}],"product":"Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 affects multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription; Msi1p localizes to nucleus and cytoplasm and independently regulates the RAS/cAMP pathway via sequestration of Npr1p kinase","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000399","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR195C"}


id: YBR196C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00839":null,"YBR196C":null},"has_protein_features":false,"name":"PGI1","ortholog_annotations":[{"gene_uniquename":"YBR196C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00839","reference_uniquename":"PMID:29761456"}],"product":"Glycolytic enzyme phosphoglucose isomerase; catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000400","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR196C"}


id: YBR196C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR; ORF emerged de novo in thymine-rich ancestral non-genic region, accumulated substantial changes under positive selection, and progressively increased its transmembrane propensity to give rise to a protein that integrates into the endoplasmic reticulum (ER) membrane while retaining potential for adaptive change","secondary_identifier":"SGD:S000028534","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR196C-A"}


id: YBR196C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028816","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR196C-B"}


id: YBR197C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000401","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR197C"}


id: YBR198C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02541":null,"YBR198C":null},"has_protein_features":false,"name":"TAF5","ortholog_annotations":[{"gene_uniquename":"YBR198C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02541","reference_uniquename":"PMID:29761456"}],"product":"Subunit (90 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000402","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR198C"}


id: YBR199W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"YBR199W":null},"has_protein_features":false,"name":"KTR4","ortholog_annotations":[{"gene_uniquename":"YBR199W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR199W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR199W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"}],"product":"Glycosyltransferase involved in protein glycosylation; transfers GDP-mannose to methyl-alpha-mannoside in vitro; member of the KRE2/MNT1 mannosyltransferase family of type II membrane proteins with a short cytoplasmic N-terminus, a membrane-spanning region and a highly conserved catalytic lumenal domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000403","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR199W"}


id: YBR200W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01794":null,"YBR200W":null},"has_protein_features":false,"name":"BEM1","ortholog_annotations":[{"gene_uniquename":"YBR200W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01794","reference_uniquename":"PMID:29761456"}],"product":"Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000404","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR200W"}


id: YBR200W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028535","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR200W-A"}


id: YBR201C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIN7","product":"Mitochondrial protein of unknown function","secondary_identifier":"SGD:S000087085","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR201C-A"}


id: YBR201W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00681":null,"SJAG_03841":null,"YBR201W":null},"has_protein_features":false,"name":"DER1","ortholog_annotations":[{"gene_uniquename":"YBR201W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00681","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR201W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03841","reference_uniquename":"PMID:29761456"}],"product":"ER membrane protein that promotes export of misfolded polypeptides; required for ER-associated protein degradation of misfolded or unassembled proteins; initiates export of aberrant polypeptides from ER lumen by threading them into ER membrane and routing them to Hrd1p for ubiquitination; function normally requires N-terminal acetylation by NatB; N- and C- termini protrude into cytoplasm; similar to Dfm1p; homolog of mammalian derlin-1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000405","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR201W"}


id: YBR202W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00884":null,"YBR202W":null},"has_protein_features":false,"name":"MCM7","ortholog_annotations":[{"gene_uniquename":"YBR202W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00884","reference_uniquename":"PMID:29761456"}],"product":"Component of the Mcm2-7 hexameric helicase complex; MCM2-7 primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000406","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR202W"}


id: YBR203W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS111","product":"Protein required for antifungal drug ciclopirox olamine resistance; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000000407","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR203W"}


id: YBR204C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03604":null,"YBR204C":null},"has_protein_features":false,"name":"LDH1","ortholog_annotations":[{"gene_uniquename":"YBR204C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03604","reference_uniquename":"PMID:29761456"}],"product":"Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000408","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR204C"}


id: YBR205W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"YBR205W":null},"has_protein_features":false,"name":"KTR3","ortholog_annotations":[{"gene_uniquename":"YBR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR205W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"}],"product":"Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000409","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR205W"}


id: YBR206W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3","secondary_identifier":"SGD:S000000410","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR206W"}


id: YBR207W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04675":null,"YBR207W":null},"has_protein_features":false,"name":"FTH1","ortholog_annotations":[{"gene_uniquename":"YBR207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04675","reference_uniquename":"PMID:29761456"}],"product":"Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000411","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR207W"}


id: YBR208C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DUR12","product":"Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000000412","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR208C"}


id: YBR209W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; YBR209W is not an essential gene","secondary_identifier":"SGD:S000000413","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR209W"}


id: YBR210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02264":null,"SJAG_04740":null,"YBR210W":null},"has_protein_features":false,"name":"ERV15","ortholog_annotations":[{"gene_uniquename":"YBR210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02264","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04740","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000414","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR210W"}


id: YBR211C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03619":null,"YBR211C":null},"has_protein_features":false,"name":"AME1","ortholog_annotations":[{"gene_uniquename":"YBR211C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03619","reference_uniquename":"PMID:29761456"}],"product":"Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000415","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR211C"}


id: YBR212W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00474":null,"SJAG_02573":null,"YBR212W":null},"has_protein_features":false,"name":"NGR1","ortholog_annotations":[{"gene_uniquename":"YBR212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00474","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YBR212W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02573","reference_uniquename":"PMID:29761456"}],"product":"RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000416","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR212W"}


id: YBR213W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01786":null,"YBR213W":null},"has_protein_features":false,"name":"MET8","ortholog_annotations":[{"gene_uniquename":"YBR213W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01786","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional dehydrogenase and ferrochelatase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000417","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR213W"}


id: YBR214W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02380":null,"YBR214W":null},"has_protein_features":false,"name":"SDS24","ortholog_annotations":[{"gene_uniquename":"YBR214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02380","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000418","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR214W"}


id: YBR215W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04561":null,"YBR215W":null},"has_protein_features":false,"name":"HPC2","ortholog_annotations":[{"gene_uniquename":"YBR215W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04561","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000419","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR215W"}


id: YBR216C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02485":null,"YBR216C":null},"has_protein_features":false,"name":"YBP1","ortholog_annotations":[{"gene_uniquename":"YBR216C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02485","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000420","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR216C"}


id: YBR217W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06309":null,"YBR217W":null},"has_protein_features":false,"name":"ATG12","ortholog_annotations":[{"gene_uniquename":"YBR217W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06309","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-like modifier involved in autophagy and the Cvt pathway; conserved; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; homolog of mammalian ULK1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR217W"}


id: YBR218C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00464":null,"YBR218C":null},"has_protein_features":false,"name":"PYC2","ortholog_annotations":[{"gene_uniquename":"YBR218C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00464","reference_uniquename":"PMID:29761456"}],"product":"Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR218C"}


id: YBR219C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YBR219C is not an essential gene","secondary_identifier":"SGD:S000000423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR219C"}


id: YBR220C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04325":null,"YBR220C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBR220C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04325","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; YBR220C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000424","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR220C"}


id: YBR221C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03064":null,"YBR221C":null},"has_protein_features":false,"name":"PDB1","ortholog_annotations":[{"gene_uniquename":"YBR221C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03064","reference_uniquename":"PMID:29761456"}],"product":"E1 beta subunit of the pyruvate dehydrogenase (PDH) complex; PDH is an evolutionarily conserved multi-protein complex found in mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR221C"}


id: YBR221W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028817","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR221W-A"}


id: YBR222C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00947":null,"YBR222C":null},"has_protein_features":false,"name":"PCS60","ortholog_annotations":[{"gene_uniquename":"YBR222C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00947","reference_uniquename":"PMID:29761456"}],"product":"Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of oxalate; peroxisomal protein that binds mRNA; localizes to both peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid; similar to E. coli long chain acyl-CoA synthetase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000426","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR222C"}


id: YBR223C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04418":null,"YBR223C":null},"has_protein_features":false,"name":"TDP1","ortholog_annotations":[{"gene_uniquename":"YBR223C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04418","reference_uniquename":"PMID:29761456"}],"product":"Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topo I and topo II, including DNA-protein cross-links; mutations in the human homolog, TDP1, result in the neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy (SCAN1); yeast cells and human rhabdomyosarcoma lines that overexpress TDP1 both exhibit elevated dosage chromosomal instability (dCIN)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000427","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR223C"}


id: YBR223W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps YBR223C; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028604","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR223W-A"}


id: YBR224W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1","secondary_identifier":"SGD:S000000428","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR224W"}


id: YBR225W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components","secondary_identifier":"SGD:S000000429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR225W"}


id: YBR226C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W","secondary_identifier":"SGD:S000000430","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR226C"}


id: YBR227C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MCX1","product":"Non-proteolytic ATPase of the AAA family; stimulates incorporation of the pyridoxal phosphate cofactor into Hem1p (5-aminolevulinic acid synthase); localized to the mitochondrial matrix; ortholog of vertebrate CLPX, which promotes erythropoiesis","secondary_identifier":"SGD:S000000431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR227C"}


id: YBR228W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05237":null,"YBR228W":null},"has_protein_features":false,"name":"SLX1","ortholog_annotations":[{"gene_uniquename":"YBR228W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05237","reference_uniquename":"PMID:29761456"}],"product":"Endonuclease involved in DNA recombination and repair; subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000432","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR228W"}


id: YBR229C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03280":null,"YBR229C":null},"has_protein_features":false,"name":"ROT2","ortholog_annotations":[{"gene_uniquename":"YBR229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03280","reference_uniquename":"PMID:29761456"}],"product":"Glucosidase II catalytic subunit; required to trim the final glucose in N-linked glycans; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000433","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR229C"}


id: YBR230C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OM14","product":"Mitochondrial outer membrane receptor for cytosolic ribosomes; integral protein of the outer membrane that interacts with the nascent chain-associated complex (NAC) bound to ribosomes, contributing to co-translational mitochondrial import; interacts with porin (Por1p) and Om45p; abundance is decreased in cells grown in glucose relative to other carbon sources","secondary_identifier":"SGD:S000000434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR230C"}


id: YBR230W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COQ21","product":"Mitochondrial protein of unknown function; YBR230W-A has a paralog, COQ8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000029722","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR230W-A"}


id: YBR231C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02466":null,"YBR231C":null},"has_protein_features":false,"name":"SWC5","ortholog_annotations":[{"gene_uniquename":"YBR231C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02466","reference_uniquename":"PMID:29761456"}],"product":"Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR231C"}


id: YBR232C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000436","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR232C"}


id: YBR233W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04825":null,"YBR233W":null},"has_protein_features":false,"name":"PBP2","ortholog_annotations":[{"gene_uniquename":"YBR233W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04825","reference_uniquename":"PMID:29761456"}],"product":"RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000437","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR233W"}


id: YBR233W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03437":null,"YBR233W-A":null},"has_protein_features":false,"name":"DAD3","ortholog_annotations":[{"gene_uniquename":"YBR233W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03437","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007595","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR233W-A"}


id: YBR234C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02075":null,"YBR234C":null},"has_protein_features":false,"name":"ARC40","ortholog_annotations":[{"gene_uniquename":"YBR234C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02075","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR234C"}


id: YBR235W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03401":null,"YBR235W":null},"has_protein_features":false,"name":"VHC1","ortholog_annotations":[{"gene_uniquename":"YBR235W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03401","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane cation-chloride cotransporter (CCC); involved in potassium homeostasis and salt tolerance; localizes to sites of contact between vacuole and mitochondria (vCLAMPs); targeted to vacuole via AP-3 pathway; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR235W"}


id: YBR236C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04034":null,"YBR236C":null},"has_protein_features":false,"name":"ABD1","ortholog_annotations":[{"gene_uniquename":"YBR236C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04034","reference_uniquename":"PMID:29761456"}],"product":"Methyltransferase; catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA; nuclear protein that relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000440","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR236C"}


id: YBR237W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02558":null,"YBR237W":null},"has_protein_features":false,"name":"PRP5","ortholog_annotations":[{"gene_uniquename":"YBR237W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02558","reference_uniquename":"PMID:29761456"}],"product":"RNA helicase in the DEAD-box family; necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR237W"}


id: YBR238C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01446":null,"YBR238C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBR238C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01446","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial membrane protein; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span; YBR238C has a paralog, RMD9, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000442","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR238C"}


id: YBR239C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ERT1","product":"Transcriptional regulator; involved in regulation of gluconeogenesis and fermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition; member of the zinc cluster family of proteins, similar to Rds2p","secondary_identifier":"SGD:S000000443","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR239C"}


id: YBR240C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"THI2","product":"Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type","secondary_identifier":"SGD:S000000444","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR240C"}


id: YBR241C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VVS1","product":"Putative transporter, member of the sugar porter family; localizes to the vacuolar membrane; non-essential gene; upregulated by and required for tolerance to 4-Methylcyclohexane methanol; YBR241C has a paralog, VPS73, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000445","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR241C"}


id: YBR242W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01055":null,"YBR242W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBR242W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01055","reference_uniquename":"PMID:29761456"}],"product":"5'-deoxynucleotidase involved in deoxyribonucleoside monophosphate degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential gene; YBR242W has a paralog, YGL101W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000446","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR242W"}


id: YBR243C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00924":null,"YBR243C":null},"has_protein_features":false,"name":"ALG7","ortholog_annotations":[{"gene_uniquename":"YBR243C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00924","reference_uniquename":"PMID:29761456"}],"product":"UDP-N-acetyl-glucosamine-1-P transferase; transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin; human homolog DPAGT1 can complement yeast ALG7 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000447","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR243C"}


id: YBR244W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01216":null,"YBR244W":null},"has_protein_features":false,"name":"GPX2","ortholog_annotations":[{"gene_uniquename":"YBR244W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01216","reference_uniquename":"PMID:29761456"}],"product":"Phospholipid hydroperoxide glutathione peroxidase; late-acting antioxidant system that decreases mitochondrial ROS production and preserves electron transport chain (ETC) function; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000448","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR244W"}


id: YBR245C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ISW1","product":"ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; with Ioc3p forms Isw1a complex involved in repression of transcription initiation; with Ioc2p and Ioc4p forms Isw1b complex involved in regulation of transcription elongation; Isw1b recruited to ORFs by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions; binds to 3'UTR of HAC1 mRNA and limits its nuclear export attenuating the UPR","secondary_identifier":"SGD:S000000449","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR245C"}


id: YBR246W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04846":null,"YBR246W":null},"has_protein_features":false,"name":"RRT2","ortholog_annotations":[{"gene_uniquename":"YBR246W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04846","reference_uniquename":"PMID:29761456"}],"product":"Methylesterase performing penultimate step of diphthamide biosynthesis; hydrolyzes methylated diphthine to produce diphthine and allows Dph6-catalyzed amidation reaction to occur; deletion leads to resistance to sordarin and accumulation of methylatediphthine; WD40 domain-containing protein; involved in endosomal recycling; forms complex with Rtt10p that functions in retromer-mediated pathway for recycling internalized cell-surface proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000450","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR246W"}


id: YBR247C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00897":null,"YBR247C":null},"has_protein_features":false,"name":"ENP1","ortholog_annotations":[{"gene_uniquename":"YBR247C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00897","reference_uniquename":"PMID:29761456"}],"product":"Protein associated with U3 and U14 snoRNAs; required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; human BYSL functionally complements the heat sensitivity of an enp1 ts mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000451","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR247C"}


id: YBR248C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03775":null,"YBR248C":null},"has_protein_features":false,"name":"HIS7","ortholog_annotations":[{"gene_uniquename":"YBR248C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03775","reference_uniquename":"PMID:29761456"}],"product":"Imidazole glycerol phosphate synthase; glutamine amidotransferase:cyclase that catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000452","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR248C"}


id: YBR249C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00224":null,"SJAG_03580":null,"YBR249C":null},"has_protein_features":false,"name":"ARO4","ortholog_annotations":[{"gene_uniquename":"YBR249C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00224","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR249C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03580","reference_uniquename":"PMID:29761456"}],"product":"3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000453","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR249C"}


id: YBR250W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPO23","product":"Protein of unknown function; associates with meiosis-specific protein Spo1p","secondary_identifier":"SGD:S000000454","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR250W"}


id: YBR251W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00628":null,"YBR251W":null},"has_protein_features":false,"name":"MRPS5","ortholog_annotations":[{"gene_uniquename":"YBR251W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00628","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR251W"}


id: YBR252W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04487":null,"YBR252W":null},"has_protein_features":false,"name":"DUT1","ortholog_annotations":[{"gene_uniquename":"YBR252W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04487","reference_uniquename":"PMID:29761456"}],"product":"Deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate; human homolog DUT allows growth of yeast haploid dut1 null mutant after sporulation of heterozygous diploid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000456","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR252W"}


id: YBR253W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05341":null,"YBR253W":null},"has_protein_features":false,"name":"SRB6","ortholog_annotations":[{"gene_uniquename":"YBR253W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05341","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000457","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR253W"}


id: YBR254C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03467":null,"YBR254C":null},"has_protein_features":false,"name":"TRS20","ortholog_annotations":[{"gene_uniquename":"YBR254C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03467","reference_uniquename":"PMID:29761456"}],"product":"Core component of transport protein particle (TRAPP) complexes I-III; TRAPPs are multimeric guanine nucleotide-exchange factors for GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); mutation leads to defects in endocytic recycling, block in sporulation/meiosis; mutations in human homolog TRAPPC2 cause spondyloepiphyseal dysplasia tarda, TRAPPC2 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000458","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR254C"}


id: YBR255C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RCF3","product":"Mitochondrial inner membrane protein; associates with respiratory chain supercomplexes III (ubiquinol-cytochrome c reductase) and IV (cytochrome c oxidase); identified by sequence comparison with hemiascomycetous yeast species","secondary_identifier":"SGD:S000007649","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR255C-A"}


id: YBR255W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MTC4","product":"Protein of unknown function; required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1","secondary_identifier":"SGD:S000000459","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR255W"}


id: YBR256C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02491":null,"YBR256C":null},"has_protein_features":false,"name":"RIB5","ortholog_annotations":[{"gene_uniquename":"YBR256C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02491","reference_uniquename":"PMID:29761456"}],"product":"Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000460","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR256C"}


id: YBR257W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01623":null,"YBR257W":null},"has_protein_features":false,"name":"POP4","ortholog_annotations":[{"gene_uniquename":"YBR257W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01623","reference_uniquename":"PMID:29761456"}],"product":"Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000461","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR257W"}


id: YBR258C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02170":null,"YBR258C":null},"has_protein_features":false,"name":"SHG1","ortholog_annotations":[{"gene_uniquename":"YBR258C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02170","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000462","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR258C"}


id: YBR259W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress","secondary_identifier":"SGD:S000000463","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR259W"}


id: YBR260C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01114":null,"YBR260C":null},"has_protein_features":false,"name":"RGD1","ortholog_annotations":[{"gene_uniquename":"YBR260C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01114","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein (RhoGAP) for Rho3p and Rho4p; involved in repolarization of actin cytoskeleton during adaptation to heat shock stress; phosphorylated by Pkc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000464","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR260C"}


id: YBR261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00508":null,"YBR261C":null},"has_protein_features":false,"name":"TAE1","ortholog_annotations":[{"gene_uniquename":"YBR261C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00508","reference_uniquename":"PMID:29761456"}],"product":"AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000465","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR261C"}


id: YBR262C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIC12","product":"Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic10p and Mic27p whose assembly and stability requires cardiolipin","secondary_identifier":"SGD:S000000466","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR262C"}


id: YBR263W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03914":null,"YBR263W":null},"has_protein_features":false,"name":"SHM1","ortholog_annotations":[{"gene_uniquename":"YBR263W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03914","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000467","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR263W"}


id: YBR264C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YPT10","product":"Rab family GTP-binding protein; contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles","secondary_identifier":"SGD:S000000468","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR264C"}


id: YBR265W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02488":null,"YBR265W":null},"has_protein_features":false,"name":"TSC10","ortholog_annotations":[{"gene_uniquename":"YBR265W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02488","reference_uniquename":"PMID:29761456"}],"product":"3-ketosphinganine reductase; catalyzes the second step in phytosphingosine synthesis; essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine; localized to lipid droplets; member of short chain dehydrogenase/reductase protein family; mutations in human homolog KDSR cause recessive progressive symmetric erythrokeratoderma","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000469","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR265W"}


id: YBR266C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SLM6","product":"Protein with potential role in actin cytoskeleton organization; null mutant is slow-growing, sensitive to Congo Red, impaired in endocytosis, has increased lifespan; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase","secondary_identifier":"SGD:S000000470","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR266C"}


id: YBR267W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03697":null,"YBR267W":null},"has_protein_features":false,"name":"REI1","ortholog_annotations":[{"gene_uniquename":"YBR267W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03697","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000471","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR267W"}


id: YBR268W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05244":null,"YBR268W":null},"has_protein_features":false,"name":"MRPL37","ortholog_annotations":[{"gene_uniquename":"YBR268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05244","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR268W"}


id: YBR269C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00703":null,"YBR269C":null},"has_protein_features":false,"name":"SDH8","ortholog_annotations":[{"gene_uniquename":"YBR269C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00703","reference_uniquename":"PMID:29761456"}],"product":"Protein required for assembly of succinate dehydrogenase; interacts with flavinylated Sdh1p and may function as a chaperone for free Sdh1p, protecting its FAD cofactor from redox reactions before assembly of the complex; soluble protein of the mitochondrial matrix; respiratory defect of null mutant is functionally complemented by Drosophila and human orthologs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000473","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR269C"}


id: YBR270C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01020":null,"SJAG_04987":null,"YBR270C":null},"has_protein_features":false,"name":"BIT2","ortholog_annotations":[{"gene_uniquename":"YBR270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01020","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR270C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04987","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000474","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR270C"}


id: YBR271W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01079":null,"YBR271W":null},"has_protein_features":false,"name":"EFM2","ortholog_annotations":[{"gene_uniquename":"YBR271W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01079","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which dimethylates translation elongation factor EF2 (Eft1p and Eft2p) at lysine 613 and methylates EF3 (Yef3p) at lysine 187; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; involved in regulation of translational termination; predicted involvement in ribosome biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000475","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR271W"}


id: YBR272C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HSM3","product":"Evolutionarily conserved 19S regulatory particle assembly-chaperone; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation; ortholog of human 19S subunit S5b","secondary_identifier":"SGD:S000000476","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR272C"}


id: YBR273C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UBX7","product":"UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000477","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR273C"}


id: YBR274W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01680":null,"YBR274W":null},"has_protein_features":false,"name":"CHK1","ortholog_annotations":[{"gene_uniquename":"YBR274W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01680","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine kinase and DNA damage checkpoint effector; mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000478","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR274W"}


id: YBR275C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01377":null,"YBR275C":null},"has_protein_features":false,"name":"RIF1","ortholog_annotations":[{"gene_uniquename":"YBR275C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01377","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in control of DNA replication; binds Rap1p C-terminus, telomeres, centromeres, replication origins; contributes to resection of DNA double strand breaks (DSBs); acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; in addition to controlling DNA replication initiation, plays ongoing role after initiation and controls events at blocked replication forks","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000479","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR275C"}


id: YBR276C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PPS1","product":"Protein phosphatase; has specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle","secondary_identifier":"SGD:S000000480","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR276C"}


id: YBR277C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W","secondary_identifier":"SGD:S000000481","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR277C"}


id: YBR278W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01823":null,"YBR278W":null},"has_protein_features":false,"name":"DPB3","ortholog_annotations":[{"gene_uniquename":"YBR278W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01823","reference_uniquename":"PMID:29761456"}],"product":"Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000482","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR278W"}


id: YBR279W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01610":null,"YBR279W":null},"has_protein_features":false,"name":"PAF1","ortholog_annotations":[{"gene_uniquename":"YBR279W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01610","reference_uniquename":"PMID:29761456"}],"product":"Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000483","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR279W"}


id: YBR280C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SAF1","product":"F-Box protein involved in proteasome-dependent degradation of Aah1p; involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1","secondary_identifier":"SGD:S000000484","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR280C"}


id: YBR281C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DUG2","product":"Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)","secondary_identifier":"SGD:S000000485","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR281C"}


id: YBR282W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04893":null,"YBR282W":null},"has_protein_features":false,"name":"MRPL27","ortholog_annotations":[{"gene_uniquename":"YBR282W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04893","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000486","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR282W"}


id: YBR283C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02208":null,"YBR283C":null},"has_protein_features":false,"name":"SSH1","ortholog_annotations":[{"gene_uniquename":"YBR283C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02208","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000487","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR283C"}


id: YBR284W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000488","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR284W"}


id: YBR285W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HAB1","product":"Autophagy receptor; highly enriched in autophagic body fractions of both rapamycin-treated and nitrogen-starved cells; binds directly to forming isolation membranes during bulk autophagy; small protein of 144 amino acid residues without any identifiable membrane-spanning regions; N-terminal 42 amino acid region contains an amphipathic helix and an Atg8-family interacting motif","secondary_identifier":"SGD:S000000489","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR285W"}


id: YBR286W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"APE3","product":"Vacuolar aminopeptidase Y; processed to mature form by Prb1p; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway","secondary_identifier":"SGD:S000000490","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR286W"}


id: YBR287W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01514":null,"YBR287W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YBR287W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01514","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000491","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR287W"}


id: YBR288C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04931":null,"YBR288C":null},"has_protein_features":false,"name":"APM3","ortholog_annotations":[{"gene_uniquename":"YBR288C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04931","reference_uniquename":"PMID:29761456"}],"product":"Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000492","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR288C"}


id: YBR289W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01111":null,"YBR289W":null},"has_protein_features":false,"name":"SNF5","ortholog_annotations":[{"gene_uniquename":"YBR289W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01111","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000493","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR289W"}


id: YBR290W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01527":null,"YBR290W":null},"has_protein_features":false,"name":"BSD2","ortholog_annotations":[{"gene_uniquename":"YBR290W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01527","reference_uniquename":"PMID:29761456"}],"product":"Heavy metal ion homeostasis protein; facilitates trafficking of Smf1p and Smf2p metal transporters to vacuole where they are degraded; acts as an adaptor protein with Rsp5p in the regulated endocytosis of Smf1p and is itself ubiquitylated by Rsp5p; controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000494","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR290W"}


id: YBR291C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01872":null,"YBR291C":null},"has_protein_features":false,"name":"CTP1","ortholog_annotations":[{"gene_uniquename":"YBR291C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01872","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000495","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR291C"}


id: YBR292C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; YBR292C is not an essential gene","secondary_identifier":"SGD:S000000496","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR292C"}


id: YBR293W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02029":null,"SJAG_04725":null,"YBR293W":null},"has_protein_features":false,"name":"VBA2","ortholog_annotations":[{"gene_uniquename":"YBR293W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02029","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YBR293W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04725","reference_uniquename":"PMID:29761456"}],"product":"Permease of basic amino acids in the vacuolar membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000497","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR293W"}


id: YBR294W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02463":null,"YBR294W":null},"has_protein_features":false,"name":"SUL1","ortholog_annotations":[{"gene_uniquename":"YBR294W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02463","reference_uniquename":"PMID:29761456"}],"product":"High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000498","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR294W"}


id: YBR295W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PCA1","product":"Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function","secondary_identifier":"SGD:S000000499","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR295W"}


id: YBR296C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PHO89","product":"Plasma membrane Na+/Pi cotransporter; active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification","secondary_identifier":"SGD:S000000500","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR296C"}


id: YBR296C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TYC1","product":"Inhibitor of the Anaphase-Promoting Complex/Cyclosome (APC/C); binds to APC/C and inhibits the activity of both APC/C(Cdc20) and APC/C(Cdh1); inhibits the binding of Cdc20 and Cdh1 to APC/C; overexpression results in increased sensitivity to microtubule poison; localizes to peroxisomes; originally identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; functional homolog of human MAD2L1BP (p31comet)","secondary_identifier":"SGD:S000028605","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR296C-A"}


id: YBR297W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MAL33","product":"MAL-activator protein; part of complex locus MAL3; nonfunctional in genomic reference strain S288C","secondary_identifier":"SGD:S000000501","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR297W"}


id: YBR298C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MAL31","product":"Maltose permease; high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C","secondary_identifier":"SGD:S000000502","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR298C"}


id: YBR298C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028606","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR298C-A"}


id: YBR299W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MAL32","product":"Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose","secondary_identifier":"SGD:S000000503","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR299W"}


id: YBR300C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene","secondary_identifier":"SGD:S000000504","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR300C"}


id: YBR301W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU24","product":"Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth","secondary_identifier":"SGD:S000000505","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR301W"}


id: YBR302C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS2","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000000506","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YBR302C"}


id: YCL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04402":null,"YCL001W":null},"has_protein_features":false,"name":"RER1","ortholog_annotations":[{"gene_uniquename":"YCL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04402","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in retention of membrane proteins; including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000507","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL001W"}


id: YCL001W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III","secondary_identifier":"SGD:S000007221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL001W-A"}


id: YCL001W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication","secondary_identifier":"SGD:S000007596","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL001W-B"}


id: YCL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YCL002C is not an essential gene","secondary_identifier":"SGD:S000000508","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL002C"}


id: YCL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCL003W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YCL004w","secondary_identifier":"SGD:S000000509","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL003W"}


id: YCL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00168":null,"YCL004W":null},"has_protein_features":false,"name":"PGS1","ortholog_annotations":[{"gene_uniquename":"YCL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00168","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylglycerolphosphate synthase; catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000510","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL004W"}


id: YCL005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LDB16","product":"Protein involved in lipid droplet (LD) assembly; forms a complex with Sei1p at ER-LD contact sites, stabilizing contact sites; ensures that LDs bud from the ER towards the cytosolic side of the membrane; null mutants have decreased net negative cell surface charge and localized accumulation of phosphatidic acid (PA) marker proteins; GFP-fusion protein expression is induced in response to MMS; null mutant can be complemented by the human seipin, BSCL2","secondary_identifier":"SGD:S000000511","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL005W"}


id: YCL005W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05294":null,"YCL005W-A":null},"has_protein_features":false,"name":"VMA9","ortholog_annotations":[{"gene_uniquename":"YCL005W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05294","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028508","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL005W-A"}


id: YCL006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this ORF was removed when a sequence update created a stop codon after residue 23","secondary_identifier":"SGD:S000000512","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL006C"}


id: YCL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A","secondary_identifier":"SGD:S000000513","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL007C"}


id: YCL008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01981":null,"YCL008C":null},"has_protein_features":false,"name":"STP22","ortholog_annotations":[{"gene_uniquename":"YCL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01981","reference_uniquename":"PMID:29761456"}],"product":"Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; prevents polyubiquitination of the arrestin-related protein Rim8p, thereby directing its monoubiquitination by Rsp5p; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype;","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000514","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL008C"}


id: YCL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06635":null,"YCL009C":null},"has_protein_features":false,"name":"ILV6","ortholog_annotations":[{"gene_uniquename":"YCL009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06635","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of acetolactate synthase; acetolactate synthase catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000515","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL009C"}


id: YCL010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00184":null,"YCL010C":null},"has_protein_features":false,"name":"SGF29","ortholog_annotations":[{"gene_uniquename":"YCL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00184","reference_uniquename":"PMID:29761456"}],"product":"Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000516","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL010C"}


id: YCL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01529":null,"YCL011C":null},"has_protein_features":false,"name":"GBP2","ortholog_annotations":[{"gene_uniquename":"YCL011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01529","reference_uniquename":"PMID:29761456"}],"product":"Poly(A+) RNA-binding protein involved in translation repression; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; relocalizes to the cytosol in response to hypoxia; GBP2 has a paralog, HRB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000517","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL011C"}


id: YCL012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00725":null,"YCL012C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YCL012C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00725","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000029705","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL012C"}


id: YCL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCL012W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YCL014W","secondary_identifier":"SGD:S000000518","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL012W"}


id: YCL013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; originally included in genome annotation but deleted due to sequence correction","secondary_identifier":"SGD:S000000519","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL013W"}


id: YCL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUD3","product":"Guanine nucleotide exchange factor (GEF) for Cdc42p; activates Cdc42p in early G1, accounting for the first stage of biphasic activation, with Cdc24p accounting for the second stage in late G1; involved in the Cdc42p-mediated assembly of the axial landmark that dictates the site for the next round of budding, resulting in the axial budding pattern in haploids; localizes with septins to the bud neck contractile ring in mitosis","secondary_identifier":"SGD:S000000520","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL014W"}


id: YCL016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00806":null,"YCL016C":null},"has_protein_features":false,"name":"DCC1","ortholog_annotations":[{"gene_uniquename":"YCL016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00806","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a complex with Ctf8p and Ctf18p; shares some components with Replication Factor C; required for sister chromatid cohesion and telomere length maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL016C"}


id: YCL017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00186":null,"YCL017C":null},"has_protein_features":false,"name":"NFS1","ortholog_annotations":[{"gene_uniquename":"YCL017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00186","reference_uniquename":"PMID:29761456"}],"product":"Cysteine desulfurase involved in iron-sulfur cluster biogenesis; required for thio-modification of mitochondrial and cytoplasmic tRNAs; involved in DNA damage response by providing iron-sulfur cluster cofactors for DNA repair enzymes; essential protein located predominantly in mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL017C"}


id: YCL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03562":null,"YCL018W":null},"has_protein_features":false,"name":"LEU2","ortholog_annotations":[{"gene_uniquename":"YCL018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03562","reference_uniquename":"PMID:29761456"}],"product":"Beta-isopropylmalate dehydrogenase (IMDH); catalyzes the third step in the leucine biosynthesis pathway; can additionally catalyze the conversion of beta-ethylmalate into alpha-ketovalerate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL018W"}


id: YCL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; originally included in genome annotation, but later deleted due to sequence correction","secondary_identifier":"SGD:S000000526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL021W"}


id: YCL021W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the vacuole","secondary_identifier":"SGD:S000007549","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL021W-A"}


id: YCL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W","secondary_identifier":"SGD:S000000527","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL022C"}


id: YCL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4","secondary_identifier":"SGD:S000000528","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL023C"}


id: YCL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03602":null,"SJAG_04486":null,"YCL024W":null},"has_protein_features":false,"name":"KCC4","ortholog_annotations":[{"gene_uniquename":"YCL024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03602","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04486","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000529","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL024W"}


id: YCL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YCL025C":null},"has_protein_features":false,"name":"AGP1","ortholog_annotations":[{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"Broad-specificity, low-affinity amino acid permease; minor serine permease with major contributions from paralog Gnp1p; involved in uptake of asparagine, glutamine, and other amino acids; expression induced by amino acids and regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000530","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL025C"}


id: YCL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; included in the original annotation of Chromosome III but later deleted due to sequence corrections","secondary_identifier":"SGD:S000000531","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL026C"}


id: YCL026C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FRM2","product":"Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin","secondary_identifier":"SGD:S000000589","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL026C-A"}


id: YCL026C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HBN1","product":"Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000007548","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL026C-B"}


id: YCL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FUS1","product":"Membrane protein localized to the shmoo tip; required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate","secondary_identifier":"SGD:S000000532","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL027W"}


id: YCL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RNQ1","product":"[PIN(+)] prion, named for [PSI+] INducibility; an infectious protein conformation that is generally an ordered protein aggregate","secondary_identifier":"SGD:S000000533","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL028W"}


id: YCL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02695":null,"YCL029C":null},"has_protein_features":false,"name":"BIK1","ortholog_annotations":[{"gene_uniquename":"YCL029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02695","reference_uniquename":"PMID:29761456"}],"product":"Microtubule-associated protein; component of the interface between microtubules and the kinetochore; involved in sister chromatid separation and mitotic spindle elongation; involved in karyogamy during mating; stabilizes Kip2p at microtubule plus ends and recruits Kip2p to mitotic SPBs; essential in polyploid cells but not in haploid or diploid cells; promotes plus-end directed movement of Dyn1p; ortholog of mammalian CLIP-170","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000534","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL029C"}


id: YCL030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01137":null,"SJAG_02400":null,"YCL030C":null},"has_protein_features":false,"name":"HIS4","ortholog_annotations":[{"gene_uniquename":"YCL030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01137","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02400","reference_uniquename":"PMID:29761456"}],"product":"Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000535","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL030C"}


id: YCL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03617":null,"YCL031C":null},"has_protein_features":false,"name":"RRP7","ortholog_annotations":[{"gene_uniquename":"YCL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03617","reference_uniquename":"PMID:29761456"}],"product":"Essential protein involved in rRNA processing and ribosome biogenesis; forms a complex with Utp22p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000536","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL031C"}


id: YCL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03340":null,"YCL032W":null},"has_protein_features":false,"name":"STE50","ortholog_annotations":[{"gene_uniquename":"YCL032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03340","reference_uniquename":"PMID:29761456"}],"product":"Adaptor protein for various signaling pathways; involved in the mating response, invasive/filamentous growth and osmotolerance; acts as an adaptor that links the G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction; localizes to cortical patches at the site of shmoo initiation, facilitating polarity establishment, and remaining at the shmoo tip during mating","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000537","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL032W"}


id: YCL033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00365":null,"YCL033C":null},"has_protein_features":false,"name":"MXR2","ortholog_annotations":[{"gene_uniquename":"YCL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00365","reference_uniquename":"PMID:29761456"}],"product":"Methionine-R-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000538","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL033C"}


id: YCL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00907":null,"YCL034W":null},"has_protein_features":false,"name":"LSB5","ortholog_annotations":[{"gene_uniquename":"YCL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00907","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in membrane-trafficking events at plasma membrane; interacts with actin regulators Sla1p and Las17p, ubiquitin, Arf3p to couple actin dynamics to membrane trafficking processes; similar structure to GGA family of proteins with N-terminal VHS domain and GAT domain; binds Las17p, which is homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly, actin polymerization; may mediate disassembly of Pan1 complex from endocytic coat","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000539","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL034W"}


id: YCL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01292":null,"SJAG_04632":null,"YCL035C":null},"has_protein_features":false,"name":"GRX1","ortholog_annotations":[{"gene_uniquename":"YCL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01292","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04632","reference_uniquename":"PMID:29761456"}],"product":"Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000540","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL035C"}


id: YCL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03874":null,"YCL036W":null},"has_protein_features":false,"name":"GFD2","ortholog_annotations":[{"gene_uniquename":"YCL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03874","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000541","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL036W"}


id: YCL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01026":null,"YCL037C":null},"has_protein_features":false,"name":"SRO9","ortholog_annotations":[{"gene_uniquename":"YCL037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01026","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic RNA-binding protein; shuttles between nucleus and cytoplasm and is exported from the nucleus in an mRNA export-dependent manner; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; role in preventing L-A mycovirus pathogenesis; SRO9 has a paralog, SLF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000542","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL037C"}


id: YCL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03899":null,"YCL038C":null},"has_protein_features":false,"name":"ATG22","ortholog_annotations":[{"gene_uniquename":"YCL038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03899","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane protein; required for efflux of amino acids during autophagic body breakdown in vacuole; targeted to vacuole via AP-3 pathway; null mutation causes gradual loss of viability during starvation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000543","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL038C"}


id: YCL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01472":null,"YCL039W":null},"has_protein_features":false,"name":"GID7","ortholog_annotations":[{"gene_uniquename":"YCL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01472","reference_uniquename":"PMID:29761456"}],"product":"Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; localizes to peroxisomes in oleate-growing cells; computational analysis suggests that Gid7p and Moh1p have similar functions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000544","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL039W"}


id: YCL040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04495":null,"YCL040W":null},"has_protein_features":false,"name":"GLK1","ortholog_annotations":[{"gene_uniquename":"YCL040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04495","reference_uniquename":"PMID:29761456"}],"product":"Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000545","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL040W"}


id: YCL041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W","secondary_identifier":"SGD:S000000546","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL041C"}


id: YCL042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm","secondary_identifier":"SGD:S000000547","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL042W"}


id: YCL043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00288":null,"YCL043C":null},"has_protein_features":false,"name":"PDI1","ortholog_annotations":[{"gene_uniquename":"YCL043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00288","reference_uniquename":"PMID:29761456"}],"product":"Protein disulfide isomerase; multifunctional oxidoreductase of the ER lumen, essential for disulfide bond formation in secretory and cell-surface proteins, processing of non-native disulfide bonds; Ero1p activator; complexes with exomannosidase, Mnl1p to facilitate the recognition of misfolded glycoproteins and the trimming of glycan Man8GlcNAc2 to Man7GlcNAc2 on substrates, thereby accelerating ERAD; PDI1 has a paralog, EUG1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000548","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL043C"}


id: YCL044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MGR1","product":"Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA","secondary_identifier":"SGD:S000000549","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL044C"}


id: YCL045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02437":null,"YCL045C":null},"has_protein_features":false,"name":"EMC1","ortholog_annotations":[{"gene_uniquename":"YCL045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02437","reference_uniquename":"PMID:29761456"}],"product":"Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000550","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL045C"}


id: YCL046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C","secondary_identifier":"SGD:S000000551","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL046W"}


id: YCL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01500":null,"YCL047C":null},"has_protein_features":false,"name":"POF1","ortholog_annotations":[{"gene_uniquename":"YCL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01500","reference_uniquename":"PMID:29761456"}],"product":"Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT); catalyzes the conversion of nicotinamide mononucleotide (NMN) to nicotinamide adenine dinucleotide (NAD+); role in the nicotinamide riboside (NR) salvage pathway of NAD+ biosynthesis; involved in NR and NAD+ homeostasis; ATPase involved in protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000552","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL047C"}


id: YCL048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00340":null,"SJAG_03483":null,"YCL048W":null},"has_protein_features":false,"name":"SPS22","ortholog_annotations":[{"gene_uniquename":"YCL048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00340","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03483","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000553","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL048W"}


id: YCL048W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCL048W-A has a paralog, YDR524C-B, that arose from the whole genome duplication","secondary_identifier":"SGD:S000087203","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL048W-A"}


id: YCL049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene","secondary_identifier":"SGD:S000000554","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL049C"}


id: YCL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"APA1","product":"AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000555","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL050C"}


id: YCL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LRE1","product":"Protein involved in control of cell wall structure and stress response; direct inhibitor of the nuclear Dbf2 related (NDR) kinase Cbk1p-Mob2p; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; LRE1 has a paralog, HLR1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000556","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL051W"}


id: YCL052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03801":null,"YCL052C":null},"has_protein_features":false,"name":"PBN1","ortholog_annotations":[{"gene_uniquename":"YCL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03801","reference_uniquename":"PMID:29761456"}],"product":"Component of glycosylphosphatidylinositol-mannosyltransferase I; essential component; required for the autocatalytic post-translational processing of the protease B precursor Prb1p; localizes to ER in lumenal orientation; homolog of mammalian PIG-X","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000557","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL052C"}


id: YCL053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; included in the original annotation of Chromosome III but later deleted due to sequence corrections","secondary_identifier":"SGD:S000000558","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL053C"}


id: YCL054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00722":null,"YCL054W":null},"has_protein_features":false,"name":"SPB1","ortholog_annotations":[{"gene_uniquename":"YCL054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00722","reference_uniquename":"PMID:29761456"}],"product":"AdoMet-dependent methyltransferase; involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000559","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL054W"}


id: YCL054W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RDT1","product":"Small gene in chromosome III recombination enhancer; activated during mating-type switching; bound by condensin complex, deletion drastically changes chromosome III structure, alters donor preference; promoter functions as locus control region (LCR) that regulates both transcription and long-range chromatin interactions","secondary_identifier":"SGD:S000178054","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL054W-A"}


id: YCL055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"KAR4","product":"Transcription factor required for the mating response; subunit of the mRNA m6A methyltransferase (MIS) complex, regulating meiosis at multiple steps, early prior to pre-meiotic S phase and late during the completion of meiosis and sporulation; exists in two forms, a slower-migrating form abundant during vegetative growth and a faster-migrating pheromone-induced form; null mutant exhibits abnormal lipid metabolic phenotype; homologous to human METTL14, a subunit of a m6A methyltransferase complex","secondary_identifier":"SGD:S000000560","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL055W"}


id: YCL056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PEX34","product":"Protein that regulates peroxisome populations; peroxisomal integral membrane protein; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation","secondary_identifier":"SGD:S000000561","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL056C"}


id: YCL057C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02002":null,"YCL057C-A":null},"has_protein_features":false,"name":"MIC10","ortholog_annotations":[{"gene_uniquename":"YCL057C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02002","reference_uniquename":"PMID:29761456"}],"product":"Conserved component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic12p and Mic27p whose assembly and stability requires cardiolipin; homo-oligomers cause membrane bending; ortholog of human MINOS1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007547","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL057C-A"}


id: YCL057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRD1","product":"Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000000562","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL057W"}


id: YCL058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FYV5","product":"De novo-originated gene from non-coding sequence; protein can suppress mating and promote vegetative growth; shortens lag phase by physically interacting with Snf1p; binds with Matalpha2p to promoters of haploid-specific genes; functions in mating and fermentation, mediates crosstalk between reproduction and vegetative growth; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis","secondary_identifier":"SGD:S000000563","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL058C"}


id: YCL058W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ADF1","product":"Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand","secondary_identifier":"SGD:S000028518","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL058W-A"}


id: YCL059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00657":null,"YCL059C":null},"has_protein_features":false,"name":"KRR1","ortholog_annotations":[{"gene_uniquename":"YCL059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00657","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein required for rRNA synthesis and ribosomal assembly; required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000564","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL059C"}


id: YCL060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCL060C was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YCL061C","secondary_identifier":"SGD:S000000565","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL060C"}


id: YCL061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04671":null,"YCL061C":null},"has_protein_features":false,"name":"MRC1","ortholog_annotations":[{"gene_uniquename":"YCL061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04671","reference_uniquename":"PMID:29761456"}],"product":"S-phase checkpoint protein required for DNA replication; couples DNA helicase and polymerase; stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; defines a novel S-phase checkpoint with Hog1p that coordinates DNA replication and transcription upon osmostress; protects uncapped telomeres; Dia2p-dependent degradation mediates checkpoint recovery; exposure to ethanol affects localization; mammalian claspin homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL061C"}


id: YCL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCL062W as originally annotated as an independent ORF, but as a result of sequence changes, it was merged with an adjacent ORF into a single reading frame, designated YCL063W","secondary_identifier":"SGD:S000000567","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL062W"}


id: YCL063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VAC17","product":"Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p; involved in regulation of asymmetric inheritance of aggregated/misfolded proteins and age reset","secondary_identifier":"SGD:S000000568","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL063W"}


id: YCL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CHA1","product":"Catabolic L-serine (L-threonine) deaminase; catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine","secondary_identifier":"SGD:S000000569","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL064C"}


id: YCL065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps HMLALPHA1","secondary_identifier":"SGD:S000000570","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL065W"}


id: YCL066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HMLALPHA1","product":"Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression","secondary_identifier":"SGD:S000000571","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL066W"}


id: YCL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HMLALPHA2","product":"Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression","secondary_identifier":"SGD:S000000572","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL067C"}


id: YCL068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02486":null,"SJAG_02819":null,"YCL068C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YCL068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02486","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YCL068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02819","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000000573","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL068C"}


id: YCL069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01336":null,"SJAG_01636":null,"SJAG_01923":null,"SJAG_04715":null,"SJAG_04983":null,"YCL069W":null},"has_protein_features":false,"name":"VBA3","ortholog_annotations":[{"gene_uniquename":"YCL069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01336","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01636","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01923","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04715","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04983","reference_uniquename":"PMID:29761456"}],"product":"Permease of basic amino acids in the vacuolar membrane; VBA3 has a paralog, VBA5, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000574","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL069W"}


id: YCL073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YCL073C":null},"has_protein_features":false,"name":"GEX1","ortholog_annotations":[{"gene_uniquename":"YCL073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCL073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role in resistance to oxidative stress and modulation of the PKA pathway; GEX1 has a paralog, GEX2, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000575","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL073C"}


id: YCL076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000581","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCL076W"}


id: YCLX01W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"L000003336","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX01W"}


id: YCLX02C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX02C"}


id: YCLX03C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000584","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX03C"}


id: YCLX04W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000585","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX04W"}


id: YCLX05C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000586","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX05C"}


id: YCLX06C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX06C"}


id: YCLX07W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000588","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX07W"}


id: YCLX09W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000590","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX09W"}


id: YCLX10C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000591","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX10C"}


id: YCLX11W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000592","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX11W"}


id: YCLX12W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000593","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCLX12W"}


id: YCR001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YCR001W is not an essential gene","secondary_identifier":"SGD:S000000594","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR001W"}


id: YCR002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00663":null,"YCR002C":null},"has_protein_features":false,"name":"CDC10","ortholog_annotations":[{"gene_uniquename":"YCR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00663","reference_uniquename":"PMID:29761456"}],"product":"Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000595","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR002C"}


id: YCR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00844":null,"YCR003W":null},"has_protein_features":false,"name":"MRPL32","ortholog_annotations":[{"gene_uniquename":"YCR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00844","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000596","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR003W"}


id: YCR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02697":null,"YCR004C":null},"has_protein_features":false,"name":"YCP4","ortholog_annotations":[{"gene_uniquename":"YCR004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02697","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000597","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR004C"}


id: YCR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01922":null,"YCR005C":null},"has_protein_features":false,"name":"CIT2","ortholog_annotations":[{"gene_uniquename":"YCR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01922","reference_uniquename":"PMID:29761456"}],"product":"Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate; expression is controlled by Rtg1p and Rtg2p transcription factors; SCF-Ucc1 regulates level of Cit2p to maintain citrate homeostasis; oxaloacetate-dependent positive feedback loop inhibits Cit2p ubiquitination; CIT2 has a paralog, CIT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000598","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR005C"}


id: YCR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YCR006C is not an essential gene","secondary_identifier":"SGD:S000000599","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR006C"}


id: YCR007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DFP3","product":"Putative integral membrane protein; member of DUP240 gene family; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCR007C is not an essential gene","secondary_identifier":"SGD:S000000600","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR007C"}


id: YCR008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04760":null,"YCR008W":null},"has_protein_features":false,"name":"SAT4","ortholog_annotations":[{"gene_uniquename":"YCR008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04760","reference_uniquename":"PMID:29761456"}],"product":"Ser/Thr protein kinase involved in salt tolerance, nutrient response; functions in regulation of Trk1p-Trk2p potassium transporter; overexpression affects the Fe-S and lipoamide containing proteins in the mitochondrion; required for lipoylation of Lat1p, Kgd2p and Gcv3p; partially redundant with Hal5p; has similarity to Npr1p; localizes to the cytoplasm and mitochondrion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000601","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR008W"}


id: YCR009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00700":null,"YCR009C":null},"has_protein_features":false,"name":"RVS161","ortholog_annotations":[{"gene_uniquename":"YCR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00700","reference_uniquename":"PMID:29761456"}],"product":"Amphiphysin-like lipid raft protein; N-BAR domain protein that interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000602","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR009C"}


id: YCR010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01505":null,"YCR010C":null},"has_protein_features":false,"name":"ADY2","ortholog_annotations":[{"gene_uniquename":"YCR010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01505","reference_uniquename":"PMID:29761456"}],"product":"Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000603","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR010C"}


id: YCR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04277":null,"YCR011C":null},"has_protein_features":false,"name":"ADP1","ortholog_annotations":[{"gene_uniquename":"YCR011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Putative ATP-dependent permease of the ABC transporter family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000604","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR011C"}


id: YCR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03660":null,"YCR012W":null},"has_protein_features":false,"name":"PGK1","ortholog_annotations":[{"gene_uniquename":"YCR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03660","reference_uniquename":"PMID:29761456"}],"product":"3-phosphoglycerate kinase; catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000605","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR012W"}


id: YCR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant","secondary_identifier":"SGD:S000000606","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR013C"}


id: YCR014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_16460":null,"YCR014C":null},"has_protein_features":false,"name":"POL4","ortholog_annotations":[{"gene_uniquename":"YCR014C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16460","reference_uniquename":"PMID:29761456"}],"product":"DNA polymerase IV; undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000607","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR014C"}


id: YCR015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00463":null,"YCR015C":null},"has_protein_features":false,"name":"CTO1","ortholog_annotations":[{"gene_uniquename":"YCR015C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00463","reference_uniquename":"PMID:29761456"}],"product":"Protein required for cold tolerance; involved in phosphate uptake; YCR015C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR015C"}


id: YCR016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RBP95","product":"RNA-binding ribosome assembly factor; constituent of early pre-60S particles; genetically and physically linked to most NOP8 60s ribosome pre-assembly complex members and to ribosomal protein Rpl3p; contains two independent RNA-interacting domains; associates with helix H95 in 3' region of 25S rRNA, in close proximity to binding sites of Npa1p and Rpl3p; interacts with several snoRNAs","secondary_identifier":"SGD:S000000609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR016W"}


id: YCR017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01227":null,"YCR017C":null},"has_protein_features":false,"name":"CWH43","ortholog_annotations":[{"gene_uniquename":"YCR017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01227","reference_uniquename":"PMID:29761456"}],"product":"GPI lipid remodelase; responsible for introducing ceramides into GPI anchors having a C26:0 fatty acid in sn-2 of the glycerol moiety; can also use lyso-GPI protein anchors and various base resistant lipids as substrates; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000610","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR017C"}


id: YCR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SRD1","product":"Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation","secondary_identifier":"SGD:S000000611","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR018C"}


id: YCR018C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; encoded opposite a Ty1 LTR","secondary_identifier":"SGD:S000007230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR018C-A"}


id: YCR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03880":null,"YCR019W":null},"has_protein_features":false,"name":"MAK32","ortholog_annotations":[{"gene_uniquename":"YCR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03880","reference_uniquename":"PMID:29761456"}],"product":"Protein necessary for stability of L-A dsRNA-containing particles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000612","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR019W"}


id: YCR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PET18","product":"Protein of unknown function; has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin","secondary_identifier":"SGD:S000000613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR020C"}


id: YCR020C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06449":null,"YCR020C-A":null},"has_protein_features":false,"name":"MAK31","ortholog_annotations":[{"gene_uniquename":"YCR020C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06449","reference_uniquename":"PMID:29761456"}],"product":"Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000614","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR020C-A"}


id: YCR020W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HTL1","product":"Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance","secondary_identifier":"SGD:S000006439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR020W-B"}


id: YCR021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02533":null,"YCR021C":null},"has_protein_features":false,"name":"HSP30","ortholog_annotations":[{"gene_uniquename":"YCR021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02533","reference_uniquename":"PMID:29761456"}],"product":"Negative regulator of the H(+)-ATPase Pma1p; stress-responsive protein; hydrophobic plasma membrane localized; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000615","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR021C"}


id: YCR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YCR022C is not an essential gene","secondary_identifier":"SGD:S000000616","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR022C"}


id: YCR023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Vacuolar membrane protein of unknown function; targeted to vacuole via AP-3 pathway; member of multidrug resistance family; not an essential gene","secondary_identifier":"SGD:S000000617","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR023C"}


id: YCR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04856":null,"YCR024C":null},"has_protein_features":false,"name":"SLM5","ortholog_annotations":[{"gene_uniquename":"YCR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04856","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial asparaginyl-tRNA synthetase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000618","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR024C"}


id: YCR024C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PMP1","product":"Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR024C-A"}


id: YCR024C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028818","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR024C-B"}


id: YCR025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; YCR025C is not an essential gene","secondary_identifier":"SGD:S000000620","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR025C"}


id: YCR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00705":null,"YCR026C":null},"has_protein_features":false,"name":"NPP1","ortholog_annotations":[{"gene_uniquename":"YCR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00705","reference_uniquename":"PMID:29761456"}],"product":"Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; NPP1 has a paralog, NPP2, that arose from the whole genome duplication, and an npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000621","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR026C"}


id: YCR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02605":null,"YCR027C":null},"has_protein_features":false,"name":"RHB1","ortholog_annotations":[{"gene_uniquename":"YCR027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02605","reference_uniquename":"PMID:29761456"}],"product":"Putative Rheb-related GTPase; involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000622","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR027C"}


id: YCR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05175":null,"YCR028C":null},"has_protein_features":false,"name":"FEN2","ortholog_annotations":[{"gene_uniquename":"YCR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05175","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000623","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR028C"}


id: YCR028C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03957":null,"YCR028C-A":null},"has_protein_features":false,"name":"RIM1","ortholog_annotations":[{"gene_uniquename":"YCR028C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03957","reference_uniquename":"PMID:29761456"}],"product":"ssDNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication; stimulates utilization by Mip1p DNA polymerase of RNA primers synthesized by Rpo41p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007222","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR028C-A"}


id: YCR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; included in the original annotation of Chromosome III but deleted due to sequence correction","secondary_identifier":"SGD:S000000624","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR029C"}


id: YCR029C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a protein; YCR029C-A was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YCR030C","secondary_identifier":"SGD:S000000625","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR029C-A"}


id: YCR030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03146":null,"YCR030C":null},"has_protein_features":false,"name":"SYP1","ortholog_annotations":[{"gene_uniquename":"YCR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03146","reference_uniquename":"PMID:29761456"}],"product":"Inhibitor of Las17p-mediated Arp2/3 complex activation; F-BAR protein that directly inhibits Las17p stimulation of Arp2/3 complex-mediated actin assembly in vitro; involved in formation of the endocytic site; intrinsically disordered domain induces bundling of Cdc11p-capped septin filaments to promote septin collar assembly, similar to mammalian ortholog FCHo2; localizes to sites of polarized growth, the septin ring, and endocytic patches; involved in actin cytoskeletal organization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR030C"}


id: YCR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01548":null,"SJAG_03424":null,"YCR031C":null},"has_protein_features":false,"name":"RPS14A","ortholog_annotations":[{"gene_uniquename":"YCR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01548","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03424","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR031C"}


id: YCR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05245":null,"YCR032W":null},"has_protein_features":false,"name":"BPH1","ortholog_annotations":[{"gene_uniquename":"YCR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05245","reference_uniquename":"PMID:29761456"}],"product":"Endosomal protein involved in endocytosis and autophagy; homologous to Chediak-Higashi syndrome and Beige proteins, both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR032W"}


id: YCR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04389":null,"YCR033W":null},"has_protein_features":false,"name":"SNT1","ortholog_annotations":[{"gene_uniquename":"YCR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04389","reference_uniquename":"PMID:29761456"}],"product":"Set3C histone deacetylase scaffold; can act as prion [ESI+] (Expressed Subtelomeric Information) that drives emergence and transgenerational inheritance of activated chromatin state; prion conformer is triggered by transient Snt1p phosphorylation upon cell cycle arrest; [ESI+] reshapes the activity Set3C, recruiting RNAPII, interfering with Rap1p binding to activate genes in otherwise repressed subtelomeric domains; relocalizes to cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR033W"}


id: YCR034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01356":null,"SJAG_02885":null,"YCR034W":null},"has_protein_features":false,"name":"ELO2","ortholog_annotations":[{"gene_uniquename":"YCR034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01356","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02885","reference_uniquename":"PMID:29761456"}],"product":"Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; ELO2 has a paralog, ELO1, that arose from the whole genome duplication; lethality of the elo2 elo3 double null mutation is functionally complemented by human ELOVL1 and weakly complemented by human ELOVL3 or ELOV7","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR034W"}


id: YCR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04084":null,"YCR035C":null},"has_protein_features":false,"name":"RRP43","ortholog_annotations":[{"gene_uniquename":"YCR035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04084","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR035C"}


id: YCR036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03174":null,"YCR036W":null},"has_protein_features":false,"name":"RBK1","ortholog_annotations":[{"gene_uniquename":"YCR036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03174","reference_uniquename":"PMID:29761456"}],"product":"Ribokinase, phosphorylates ribose to ribose-5-phosphate; required for recycling ribose during nucleotide metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR036W"}


id: YCR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01059":null,"YCR037C":null},"has_protein_features":false,"name":"PHO87","ortholog_annotations":[{"gene_uniquename":"YCR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01059","reference_uniquename":"PMID:29761456"}],"product":"Low-affinity inorganic phosphate (Pi) transporter; acts upstream of Pho81p in regulation of PHO pathway; targeted to vacuole via AP-3 pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000633","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR037C"}


id: YCR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02486":null,"SJAG_02819":null,"YCR038C":null},"has_protein_features":false,"name":"BUD5","ortholog_annotations":[{"gene_uniquename":"YCR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02486","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YCR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02819","reference_uniquename":"PMID:26896847"}],"product":"GTP/GDP exchange factor for Rsr1p (Bud1p); required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000000634","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR038C"}


id: YCR038W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene BUD5/YCR038C; identified by homology with hemiascomycetous yeast species","secondary_identifier":"SGD:S000007597","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR038W-A"}


id: YCR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MATALPHA2","product":"Homeobox-domain protein; with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette","secondary_identifier":"SGD:S000000635","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR039C"}


id: YCR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MATALPHA1","product":"Transcriptional co-activator that regulates mating-type-specific genes; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha mating type cassette","secondary_identifier":"SGD:S000000636","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR040W"}


id: YCR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; overexpression suppresses the high-frequency loss of mini-chromosomes, probably by increasing the rate of proper chromosome segregation; translated gene product of YCR041W, but not its transcript, is responsible for suppression; suppression ability of YCR041W is completely dependent on silencing protein Sir4p","secondary_identifier":"SGD:S000000637","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR041W"}


id: YCR042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04917":null,"YCR042C":null},"has_protein_features":false,"name":"TAF2","ortholog_annotations":[{"gene_uniquename":"YCR042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04917","reference_uniquename":"PMID:29761456"}],"product":"TFIID subunit (150 kDa); involved in RNA polymerase II transcription initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR042C"}


id: YCR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene","secondary_identifier":"SGD:S000000639","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR043C"}


id: YCR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04975":null,"YCR044C":null},"has_protein_features":false,"name":"PER1","ortholog_annotations":[{"gene_uniquename":"YCR044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04975","reference_uniquename":"PMID:29761456"}],"product":"Protein of the endoplasmic reticulum; required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000640","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR044C"}


id: YCR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRT12","product":"Probable subtilisin-family protease; role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores","secondary_identifier":"SGD:S000000641","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR045C"}


id: YCR045W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with YCR045C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028607","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR045W-A"}


id: YCR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01473":null,"YCR046C":null},"has_protein_features":false,"name":"IMG1","ortholog_annotations":[{"gene_uniquename":"YCR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01473","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; required for respiration and for maintenance of the mitochondrial genome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR046C"}


id: YCR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02281":null,"YCR047C":null},"has_protein_features":false,"name":"BUD23","ortholog_annotations":[{"gene_uniquename":"YCR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02281","reference_uniquename":"PMID:29761456"}],"product":"Ribosome biogenesis factor; methyltransferase that methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; required for recruitment of Rps2p; functions with DEAH-box RNA helicase Ecm16p; diploid mutant displays random budding pattern; functional homolog of human WBSCR22","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR047C"}


id: YCR047W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with YCR047C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR047W-A"}


id: YCR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04049":null,"SJAG_04059":null,"YCR048W":null},"has_protein_features":false,"name":"ARE1","ortholog_annotations":[{"gene_uniquename":"YCR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04049","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04059","reference_uniquename":"PMID:29761456"}],"product":"Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR048W"}


id: YCR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR049C"}


id: YCR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein","secondary_identifier":"SGD:S000000646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR050C"}


id: YCR051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01812":null,"YCR051W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YCR051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01812","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR051W"}


id: YCR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00739":null,"YCR052W":null},"has_protein_features":false,"name":"RSC6","ortholog_annotations":[{"gene_uniquename":"YCR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00739","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; essential for mitotic growth; RSC6 has a paralog, SNF12, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000648","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR052W"}


id: YCR053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00432":null,"YCR053W":null},"has_protein_features":false,"name":"THR4","ortholog_annotations":[{"gene_uniquename":"YCR053W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00432","reference_uniquename":"PMID:29761456"}],"product":"Threonine synthase; conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000649","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR053W"}


id: YCR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03692":null,"YCR054C":null},"has_protein_features":false,"name":"CTR86","ortholog_annotations":[{"gene_uniquename":"YCR054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03692","reference_uniquename":"PMID:29761456"}],"product":"Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000650","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR054C"}


id: YCR055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCR055C was originally annotated as an independent ORF, but as a result of sequence changes, it was merged with two other ORFs into a single reading frame, designated YCR057C","secondary_identifier":"SGD:S000000651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR055C"}


id: YCR056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; originally included in genome annotation, but later deleted due to sequence correction","secondary_identifier":"SGD:S000000652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR056W"}


id: YCR057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00572":null,"YCR057C":null},"has_protein_features":false,"name":"PWP2","ortholog_annotations":[{"gene_uniquename":"YCR057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00572","reference_uniquename":"PMID:29761456"}],"product":"Conserved 90S pre-ribosomal component; essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000653","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR057C"}


id: YCR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCR058C was originally annotated as an independent ORF, but as a result of sequence changes, it was merged with two other ORFs into a single reading frame, designated YCR057C","secondary_identifier":"SGD:S000000654","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR058C"}


id: YCR059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04873":null,"YCR059C":null},"has_protein_features":false,"name":"YIH1","ortholog_annotations":[{"gene_uniquename":"YCR059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04873","reference_uniquename":"PMID:29761456"}],"product":"Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR059C"}


id: YCR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TAH1","product":"Component of conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly of large protein complexes such as box C/D snoRNPs and RNA polymerase II; contains a single TPR domain with at least two TPR motifs; plays a role in determining prion variants","secondary_identifier":"SGD:S000000656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR060W"}


id: YCR061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TVS1","product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; non-essential gene; upregulated by and required for tolerance to 4-Methylcyclohexane methanol; induced by treatment with 8-methoxypsoralen and UVA irradiation; contains 10-11 predicted transmembrane domains","secondary_identifier":"SGD:S000000657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR061W"}


id: YCR062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCR062W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YCR061W","secondary_identifier":"SGD:S000000658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR062W"}


id: YCR063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02227":null,"YCR063W":null},"has_protein_features":false,"name":"BUD31","ortholog_annotations":[{"gene_uniquename":"YCR063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02227","reference_uniquename":"PMID:29761456"}],"product":"Component of the SF3b subcomplex of the U2 snRNP; increases efficiency of first and second step pre-mRNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR063W"}


id: YCR064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BUD31","secondary_identifier":"SGD:S000000660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR064C"}


id: YCR065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03143":null,"SJAG_05288":null,"YCR065W":null},"has_protein_features":false,"name":"HCM1","ortholog_annotations":[{"gene_uniquename":"YCR065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03143","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05288","reference_uniquename":"PMID:29761456"}],"product":"Forkhead transcription factor; drives S-phase activation of genes involved in chromosome segregation, spindle dynamics, budding; also activates genes involved in respiration, use of alternative energy sources, NAD synthesis, oxidative stress resistance; regulated by cell wall integrity checkpoint; key factor in early adaptation to nutrient deficiency and diauxic shift; suppressor of calmodulin mutants with specific SPB assembly defects; ortholog of C. elegans lifespan regulator PHA-4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR065W"}


id: YCR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00819":null,"YCR066W":null},"has_protein_features":false,"name":"RAD18","ortholog_annotations":[{"gene_uniquename":"YCR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00819","reference_uniquename":"PMID:29761456"}],"product":"E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR066W"}


id: YCR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SED4","product":"Integral ER membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; SED4 has a paralog, SEC12, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000663","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR067C"}


id: YCR068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02100":null,"YCR068W":null},"has_protein_features":false,"name":"ATG15","ortholog_annotations":[{"gene_uniquename":"YCR068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02100","reference_uniquename":"PMID:29761456"}],"product":"Phospholipase B; hydrolyses phosphatidylserine; minor activity against cardiolipin and PtdEtn; required for lysis of autophagic and CVT bodies; targeted to the vacuole via the Pep1p-dependent endosomal VPS pathway; targeted to intravacuolar vesicles during autophagy by the MVB pathway; maintains lipid droplet quantity after the diauxic shift; regulates lipolysis; single membrane spanning protein with cytosolic N-term and the rest in the ER lumen; expression regulated by Yap1p during autophagy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000664","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR068W"}


id: YCR069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CPR4","product":"Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; CPR4 has a paralog, CPR8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000665","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR069W"}


id: YCR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted open reading frame; YCR070W was originally annotated as an ORF, but upon further review was deleted from the genome annotation","secondary_identifier":"SGD:S000000666","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR070W"}


id: YCR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IMG2","product":"Mitochondrial ribosomal protein of the large subunit; conserved in metazoa, with similarity to human mitochondrial ribosomal protein MRPL49","secondary_identifier":"SGD:S000000667","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR071C"}


id: YCR072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02754":null,"YCR072C":null},"has_protein_features":false,"name":"RSA4","ortholog_annotations":[{"gene_uniquename":"YCR072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02754","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal large subunit (60S) assembly factor; association of the N-terminal ubiquitin-like (UBL) domain of this preribosomal factor with the MIDAS domain in the Rea1p tail, promoted by the GTPase Nog2p, is required for the ATP-dependent dissociation of preribosomal factors including the Rix1p subcomplex, Rea1p, Nog2p and Rsa1p itself prior to nuclear export of pre-60S particles; contains WD-repeats and a UBL domain; localizes to the nucleolus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000668","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR072C"}


id: YCR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03384":null,"SJAG_04777":null,"YCR073C":null},"has_protein_features":false,"name":"SSK22","ortholog_annotations":[{"gene_uniquename":"YCR073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03384","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04777","reference_uniquename":"PMID:29761456"}],"product":"MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; functionally redundant with Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p; SSK22 has a paralog, SSK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR073C"}


id: YCR073W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01824":null,"YCR073W-A":null},"has_protein_features":false,"name":"SOL2","ortholog_annotations":[{"gene_uniquename":"YCR073W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01824","reference_uniquename":"PMID:29761456"}],"product":"Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000718","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR073W-A"}


id: YCR074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; included in the original annotation of Chromosome III but later withdrawn","secondary_identifier":"SGD:S000119982","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR074C"}


id: YCR075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ERS1","product":"Protein involved in cystine transport; localizes to the vacuole, plasma membrane and endosome; similarity to human cystinosin, a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains; mutation is functionally complemented by human CTNS","secondary_identifier":"SGD:S000000671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR075C"}


id: YCR075W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EGO2","product":"Subunit of the EGO/GSE complex; the vacuolar/endosomal membrane associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from the endosome to the plasma membrane; identified by homology to Ashbya gossypii; EGO2 has a paralog, EGO4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000028519","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR075W-A"}


id: YCR076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04633":null,"YCR076C":null},"has_protein_features":false,"name":"FUB1","ortholog_annotations":[{"gene_uniquename":"YCR076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04633","reference_uniquename":"PMID:29761456"}],"product":"Proteasome-binding protein; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; specifically blocks all three proteasome active sites; exhibits boundary activity which inhibits the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR076C"}


id: YCR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02213":null,"YCR077C":null},"has_protein_features":false,"name":"PAT1","ortholog_annotations":[{"gene_uniquename":"YCR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02213","reference_uniquename":"PMID:29761456"}],"product":"Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; binds to mRNAs under glucose starvation, most often in the 3' UTR; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress; phosphorylation by PKA inhibits P body foci formation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR077C"}


id: YCR079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02433":null,"YCR079W":null},"has_protein_features":false,"name":"PTC6","ortholog_annotations":[{"gene_uniquename":"YCR079W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02433","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial type 2C protein phosphatase (PP2C); has similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002133","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR079W"}


id: YCR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YCR080W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YCR081W","secondary_identifier":"SGD:S000000676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR080W"}


id: YCR081C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with SRB8/YCR081W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR081C-A"}


id: YCR081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00156":null,"YCR081W":null},"has_protein_features":false,"name":"SRB8","ortholog_annotations":[{"gene_uniquename":"YCR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00156","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR081W"}


id: YCR082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AHC2","product":"Component of the ADA histone acetyltransferase complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ahc1p to the complex","secondary_identifier":"SGD:S000000678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR082W"}


id: YCR083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00614":null,"SJAG_04953":null,"YCR083W":null},"has_protein_features":false,"name":"TRX3","ortholog_annotations":[{"gene_uniquename":"YCR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00614","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04953","reference_uniquename":"PMID:26896847"}],"product":"Mitochondrial thioredoxin; highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000679","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR083W"}


id: YCR084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00290":null,"SJAG_04921":null,"YCR084C":null},"has_protein_features":false,"name":"TUP1","ortholog_annotations":[{"gene_uniquename":"YCR084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00290","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04921","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional regulator; functions primarily as a transcriptional co-repressor with Cyc8p but can also function as a co-activator, recruiting SWI/SNF and SAGA complexes to promoters; target genes may be uniquely repressed by Tup1p or Cyc8p, subject to redundant repression, or in some cases de-repression of target genes in a tup1 mutant is dependent upon CYC8 and vice versa; establishes a repressive chromatin structure via histone H3/H4 interactions and stabilizing nucleosomes over promoters","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000680","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR084C"}


id: YCR085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YCR085W is not an essential gene","secondary_identifier":"SGD:S000000681","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR085W"}


id: YCR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00207":null,"YCR086W":null},"has_protein_features":false,"name":"CSM1","ortholog_annotations":[{"gene_uniquename":"YCR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00207","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein that mediates homolog segregation during meiosis I; forms a complex with Lrs4p and then Mam1p at kinetochores; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000682","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR086W"}


id: YCR087C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00410":null,"YCR087C-A":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YCR087C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00410","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; binds zinc; phosphomutants exhibit phenotypes, suggesting functionality of phosphosites; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR087C-A"}


id: YCR087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene","secondary_identifier":"SGD:S000000683","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR087W"}


id: YCR088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02566":null,"YCR088W":null},"has_protein_features":false,"name":"ABP1","ortholog_annotations":[{"gene_uniquename":"YCR088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02566","reference_uniquename":"PMID:29761456"}],"product":"Actin-binding protein of the cortical actin cytoskeleton; important for activation of actin nucleation mediated by the Arp2/Arp3 complex; inhibits actin filament elongation at the barbed-end; phosphorylation within its proline-rich region, mediated by Cdc28p and Pho85p, protects Abp1p from PEST sequence-mediated proteolysis; mammalian homolog of HIP-55 (hematopoietic progenitor kinase 1 [HPK1]-interacting protein of 55 kDa)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR088W"}


id: YCR089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FIG2","product":"Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating; FIG2 has a paralog, AGA1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000685","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR089W"}


id: YCR090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01266":null,"YCR090C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YCR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01266","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000686","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR090C"}


id: YCR091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03209":null,"SJAG_04734":null,"YCR091W":null},"has_protein_features":false,"name":"KIN82","ortholog_annotations":[{"gene_uniquename":"YCR091W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03209","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR091W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04734","reference_uniquename":"PMID:29761456"}],"product":"Putative serine/threonine protein kinase; implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases); involved in the phosphorylation of upstream inhibitory kinase Ypk1p along with Fpk1p; has a redundant role in the cellular response to mating pheromone; KIN82 has a paralog, FPK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000687","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR091W"}


id: YCR092C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01419":null,"YCR092C":null},"has_protein_features":false,"name":"MSH3","ortholog_annotations":[{"gene_uniquename":"YCR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01419","reference_uniquename":"PMID:29761456"}],"product":"Mismatch repair protein; forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000688","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR092C"}


id: YCR093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03597":null,"YCR093W":null},"has_protein_features":false,"name":"CDC39","ortholog_annotations":[{"gene_uniquename":"YCR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03597","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the CCR4-NOT1 core complex; this complex has multiple roles in the regulation of mRNA levels including regulation of transcription and destabilization of mRNA by deadenylation; basal transcription factor that increases initiation and elongation; activates the ATPase activity of Dhh1p, resulting in processing body disassembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000689","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR093W"}


id: YCR094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02516":null,"SJAG_03050":null,"YCR094W":null},"has_protein_features":false,"name":"CDC50","ortholog_annotations":[{"gene_uniquename":"YCR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02516","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03050","reference_uniquename":"PMID:29761456"}],"product":"Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000690","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR094W"}


id: YCR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OCA4","product":"Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts","secondary_identifier":"SGD:S000000691","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR095C"}


id: YCR095W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000029724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR095W-A"}


id: YCR096C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HMRA2","product":"Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system","secondary_identifier":"SGD:S000000692","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR096C"}


id: YCR097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HMRA1","product":"Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells","secondary_identifier":"SGD:S000000694","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR097W"}


id: YCR097W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by homology to a hemiascomycetous yeast protein","secondary_identifier":"SGD:S000007632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR097W-A"}


id: YCR097WA
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; YCR097WA refers to an incorrect annotation of HMRA1 that appeared in the original version of Chromosome III (1996) but was later withdrawn and subsequently removed from SGD","secondary_identifier":"SGD:S000000693","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR097WA"}


id: YCR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00232":null,"SJAG_03644":null,"SJAG_05325":null,"YCR098C":null},"has_protein_features":false,"name":"GIT1","ortholog_annotations":[{"gene_uniquename":"YCR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00232","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03644","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YCR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05325","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000695","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR098C"}


id: YCR099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000000696","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR099C"}


id: YCR100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EMA35","product":"Protein involved in protein sorting; involved in targeting mitochondrial membrane proteins to mitochondrial translocation system; mutation causes respiration defects","secondary_identifier":"SGD:S000000697","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR100C"}


id: YCR101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene","secondary_identifier":"SGD:S000000698","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR101C"}


id: YCR102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative quinone oxidoreductase; overexpression improves ethanol production and acid stress resistance; involved in copper metabolism; similar to Cochliobolus carbonum toxD gene","secondary_identifier":"SGD:S000000699","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR102C"}


id: YCR102W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR102W-A"}


id: YCR103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this ORF was removed when a sequence update created a stop codon after residue 45","secondary_identifier":"SGD:S000000700","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR103C"}


id: YCR104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU3","product":"Member of the seripauperin multigene family; encoded mainly in subtelomeric region; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme","secondary_identifier":"SGD:S000000701","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR104W"}


id: YCR105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02963":null,"YCR105W":null},"has_protein_features":false,"name":"ADH7","ortholog_annotations":[{"gene_uniquename":"YCR105W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02963","reference_uniquename":"PMID:26896847"}],"product":"NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000000702","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR105W"}


id: YCR106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RDS1","product":"Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide","secondary_identifier":"SGD:S000000703","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR106W"}


id: YCR107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AAD3","product":"Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD3 has a paralog, AAD15, that arose from a segmental duplication; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family","secondary_identifier":"SGD:S000000704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR107W"}


id: YCR108C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028536","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCR108C"}


id: YCRX01W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119988","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX01W"}


id: YCRX02C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119989","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX02C"}


id: YCRX03C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000708","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX03C"}


id: YCRX04W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119990","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX04W"}


id: YCRX05W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000710","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX05W"}


id: YCRX06W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119991","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX06W"}


id: YCRX07W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000712","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX07W"}


id: YCRX08W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119992","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX08W"}


id: YCRX09C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119993","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX09C"}


id: YCRX10W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000715","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX10W"}


id: YCRX11W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119994","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX11W"}


id: YCRX12W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000717","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX12W"}


id: YCRX14W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000719","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX14W"}


id: YCRX15W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000720","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX15W"}


id: YCRX16C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000721","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX16C"}


id: YCRX17W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119995","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX17W"}


id: YCRX18C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000723","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX18C"}


id: YCRX19W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000119996","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX19W"}


id: YCRX20C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000725","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX20C"}


id: YCRX21C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; this putative ORF was included in the original annotation of Chromosome III but was later withdrawn","secondary_identifier":"SGD:S000000726","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YCRX21C"}


id: YDL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01174":null,"SJAG_02548":null,"YDL001W":null},"has_protein_features":false,"name":"RMD1","ortholog_annotations":[{"gene_uniquename":"YDL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01174","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02548","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic protein required for sporulation; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002159","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL001W"}


id: YDL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05020":null,"YDL002C":null},"has_protein_features":false,"name":"NHP10","ortholog_annotations":[{"gene_uniquename":"YDL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05020","reference_uniquename":"PMID:29761456"}],"product":"Non-essential INO80 chromatin remodeling complex subunit; preferentially binds DNA ends, protecting them from exonucleatic cleavage; deletion affects telomere maintenance via recombination; related to mammalian high mobility group proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002160","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL002C"}


id: YDL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01067":null,"YDL003W":null},"has_protein_features":false,"name":"MCD1","ortholog_annotations":[{"gene_uniquename":"YDL003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01067","reference_uniquename":"PMID:29761456"}],"product":"Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis; subject to proteolytic cleavage by separase Esp1p, resulting in dissociation of cohesin from chromatin and the separation of sister chromatids at the mitotic metaphase-to-anaphase transition; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002161","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL003W"}


id: YDL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03114":null,"YDL004W":null},"has_protein_features":false,"name":"ATP16","ortholog_annotations":[{"gene_uniquename":"YDL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03114","reference_uniquename":"PMID:29761456"}],"product":"Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002162","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL004W"}


id: YDL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MED2","product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; relocalizes to the cytosol in response to hypoxia","secondary_identifier":"SGD:S000002163","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL005C"}


id: YDL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03185":null,"YDL006W":null},"has_protein_features":false,"name":"PTC1","ortholog_annotations":[{"gene_uniquename":"YDL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03185","reference_uniquename":"PMID:29761456"}],"product":"Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating the osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation; involved in myosin-V dependent inheritance of mitochondria, peroxisomes, vacuoles and secretory vesicles; localizes to the nucleus, cytoplasm and peroxisomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002164","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL006W"}


id: YDL007C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000113557","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL007C-A"}


id: YDL007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00712":null,"YDL007W":null},"has_protein_features":false,"name":"RPT2","ortholog_annotations":[{"gene_uniquename":"YDL007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00712","reference_uniquename":"PMID:29761456"}],"product":"ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle; N-myristoylation of Rpt2p at Gly2 is involved in regulating the proper intracellular distribution of proteasome activity by controlling the nuclear localization of the 26S proteasome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002165","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL007W"}


id: YDL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05236":null,"YDL008W":null},"has_protein_features":false,"name":"APC11","ortholog_annotations":[{"gene_uniquename":"YDL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05236","reference_uniquename":"PMID:29761456"}],"product":"Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002166","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL008W"}


id: YDL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data; SWAT-GFP and mCherry fusion proteins localize to the cytosol; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene","secondary_identifier":"SGD:S000002167","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL009C"}


id: YDL010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02495":null,"YDL010W":null},"has_protein_features":false,"name":"GRX6","ortholog_annotations":[{"gene_uniquename":"YDL010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02495","reference_uniquename":"PMID:29761456"}],"product":"Cis-Golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002168","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL010W"}


id: YDL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W","secondary_identifier":"SGD:S000002169","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL011C"}


id: YDL012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02333":null,"YDL012C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDL012C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02333","reference_uniquename":"PMID:29761456"}],"product":"Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002170","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL012C"}


id: YDL013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01572":null,"SJAG_05012":null,"YDL013W":null},"has_protein_features":false,"name":"SLX5","ortholog_annotations":[{"gene_uniquename":"YDL013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01572","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05012","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex; role in Ub-mediated degradation of histone variant Cse4p preventing mislocalization to euchromatin; role in proteolysis of spindle positioning protein Kar9p, and DNA repair proteins Rad52p and Rad57p; forms SUMO-dependent nuclear foci, including DNA repair centers; contains a RING domain and two SIM motifs; associates with the centromere; required for maintenance of genome integrity like human ortholog RNF4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002171","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL013W"}


id: YDL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00943":null,"YDL014W":null},"has_protein_features":false,"name":"NOP1","ortholog_annotations":[{"gene_uniquename":"YDL014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00943","reference_uniquename":"PMID:29761456"}],"product":"Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; ortholog of mammalian fibrillarin; inviability of the null mutant is functionally complemented by human FBL","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002172","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL014W"}


id: YDL015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02717":null,"YDL015C":null},"has_protein_features":false,"name":"TSC13","ortholog_annotations":[{"gene_uniquename":"YDL015C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02717","reference_uniquename":"PMID:29761456"}],"product":"Enoyl reductase; catalyzes last step in each cycle of very long chain fatty acid elongation; localizes to ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Elo2p and Elo3p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress; human homolog TECR implicated in nonsyndromic mental retardation, can complement yeast mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002173","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL015C"}


id: YDL016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication","secondary_identifier":"SGD:S000002174","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL016C"}


id: YDL017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00486":null,"SJAG_03160":null,"YDL017W":null},"has_protein_features":false,"name":"CDC7","ortholog_annotations":[{"gene_uniquename":"YDL017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00486","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03160","reference_uniquename":"PMID:29761456"}],"product":"S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase); required for origin firing and replication initiation; phosphorylates MCM subunits and Cdc45 to drive assembly of the pre-IC and the CMG helicase; maintains Cse4p at kinetochores through phosphorylation to regulate chromosome segregation, regulates pre-meiotic replication, meiotic DSB formation, monopolar attachment of homologs during MI through monopolin recruitment and middle meiotic gene expression; HsCDC7 and DBF4 complement","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002175","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL017W"}


id: YDL018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03270":null,"YDL018C":null},"has_protein_features":false,"name":"ERP3","ortholog_annotations":[{"gene_uniquename":"YDL018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03270","reference_uniquename":"PMID:29761456"}],"product":"Protein with similarity to Emp24p and Erv25p; member of the p24 family involved in ER to Golgi transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002176","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL018C"}


id: YDL019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01722":null,"YDL019C":null},"has_protein_features":false,"name":"OSH2","ortholog_annotations":[{"gene_uniquename":"YDL019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01722","reference_uniquename":"PMID:29761456"}],"product":"Member of an oxysterol-binding protein family with seven members; in S. cerevisiae, family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane and at the nuclear envelope; regulated by sterol binding; OSH2 has a paralog, SWH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002177","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL019C"}


id: YDL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00304":null,"YDL020C":null},"has_protein_features":false,"name":"RPN4","ortholog_annotations":[{"gene_uniquename":"YDL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00304","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002178","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL020C"}


id: YDL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02009":null,"YDL021W":null},"has_protein_features":false,"name":"GPM2","ortholog_annotations":[{"gene_uniquename":"YDL021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02009","reference_uniquename":"PMID:29761456"}],"product":"Nonfunctional homolog of Gpm1p phosphoglycerate mutase; if functional, would convert 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; GPM2 has a paralog, GPM3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002179","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL021W"}


id: YDL022C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cytosol; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR; mRNA identified as translated by ribosome profiling data","secondary_identifier":"SGD:S000028537","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL022C-A"}


id: YDL022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00409":null,"SJAG_01012":null,"YDL022W":null},"has_protein_features":false,"name":"GPD1","ortholog_annotations":[{"gene_uniquename":"YDL022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00409","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01012","reference_uniquename":"PMID:29761456"}],"product":"NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases Ypk1p and Ypk2p, dephosphorylation increases catalytic activity; forms a heterodimer with Pnc1p to facilitate its peroxisomal import","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002180","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL022W"}


id: YDL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance","secondary_identifier":"SGD:S000002181","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL023C"}


id: YDL024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01970":null,"SJAG_04067":null,"YDL024C":null},"has_protein_features":false,"name":"DIA3","ortholog_annotations":[{"gene_uniquename":"YDL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01970","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04067","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; involved in invasive and pseudohyphal growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002182","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL024C"}


id: YDL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00963":null,"SJAG_04268":null,"YDL025C":null},"has_protein_features":false,"name":"RTK1","ortholog_annotations":[{"gene_uniquename":"YDL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00963","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04268","reference_uniquename":"PMID:29761456"}],"product":"Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002183","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL025C"}


id: YDL025W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the ORF YDL025C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028610","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL025W-A"}


id: YDL026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002184","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL026W"}


id: YDL027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRX9","product":"Mitochondrial inner membrane protein; high copy suppressor of ER stress-mediated cell death; overexpression increases O2 consumption, impairs processing of COB and COX1 RNAs encoding mitochondrial oxidative phosphorylation factors, and impacts the transition from fermentative to respiratory metabolism","secondary_identifier":"SGD:S000002185","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL027C"}


id: YDL028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04126":null,"YDL028C":null},"has_protein_features":false,"name":"MPS1","ortholog_annotations":[{"gene_uniquename":"YDL028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04126","reference_uniquename":"PMID:29761456"}],"product":"Dual-specificity kinase; required for SPB duplication and spindle checkpoint function in mitosis and meiosis; contributes to bi-orientation, promoting formation of force-generating kinetochore-microtubule attachments in meiosis I; autophosphorylation required for function; substrates include SPB proteins (Spc42p, Spc110p, Spc98p), mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p; substrate of APCC(Cdh1); detected in peroxisomes; similar to human Mps1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002186","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL028C"}


id: YDL029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01964":null,"YDL029W":null},"has_protein_features":false,"name":"ARP2","ortholog_annotations":[{"gene_uniquename":"YDL029W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01964","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; required for efficient Golgi-to-ER trafficking in COPI mutants","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002187","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL029W"}


id: YDL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00577":null,"YDL030W":null},"has_protein_features":false,"name":"PRP9","ortholog_annotations":[{"gene_uniquename":"YDL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00577","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SF3a splicing factor complex; required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002188","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL030W"}


id: YDL031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00798":null,"YDL031W":null},"has_protein_features":false,"name":"DBP10","ortholog_annotations":[{"gene_uniquename":"YDL031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00798","reference_uniquename":"PMID:29761456"}],"product":"Putative ATP-dependent RNA helicase of the DEAD-box protein family; constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002189","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL031W"}


id: YDL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene","secondary_identifier":"SGD:S000002190","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL032W"}


id: YDL033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00358":null,"YDL033C":null},"has_protein_features":false,"name":"SLM3","ortholog_annotations":[{"gene_uniquename":"YDL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00358","reference_uniquename":"PMID:29761456"}],"product":"tRNA-specific 2-thiouridylase; responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human homolog TRMU is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF), and can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002191","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL033C"}


id: YDL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene","secondary_identifier":"SGD:S000002192","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL034W"}


id: YDL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01699":null,"YDL035C":null},"has_protein_features":false,"name":"GPR1","ortholog_annotations":[{"gene_uniquename":"YDL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01699","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane G protein coupled receptor (GPCR); interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002193","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL035C"}


id: YDL036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01172":null,"YDL036C":null},"has_protein_features":false,"name":"PUS9","ortholog_annotations":[{"gene_uniquename":"YDL036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01172","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial tRNA:pseudouridine synthase; catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence; PUS9 has a paralog, RIB2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002194","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL036C"}


id: YDL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BSC1","product":"Protein of unconfirmed function; similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; in W303 strain one continuous open reading frame comprising of YDL037C, the intergenic region and YDL039C encodes the gene IMI1","secondary_identifier":"SGD:S000002195","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL037C"}


id: YDL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YDL038C was originally annotated as an independent ORF, but as a result of a sequence correction, was merged with adjacent ORF PRM7/YDL039C into a single open reading frame","secondary_identifier":"SGD:S000002196","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL038C"}


id: YDL039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRM7","product":"Pheromone-regulated protein; predicted to have one transmembrane segment; promoter contains Gcn4p binding elements; in W303 strain one continuous open reading frame comprising of YDL037C, the intergenic region and YDL039C encodes the IMI1","secondary_identifier":"SGD:S000002197","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL039C"}


id: YDL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02920":null,"SJAG_04179":null,"YDL040C":null},"has_protein_features":false,"name":"NAT1","ortholog_annotations":[{"gene_uniquename":"YDL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02920","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04179","reference_uniquename":"PMID:29761456"}],"product":"Subunit of protein N-terminal acetyltransferase NatA; NatA comprised of Nat1p, Ard1p, and Nat5p; N-terminally acetylates many proteins to influence multiple processes such as cell cycle progression, heat-shock resistance, mating, sporulation, telomeric silencing and early stages of mitophagy; orthologous to human NAA15; expression of both human NAA10 and NAA15 functionally complements ard1 nat1 double mutant although single mutations are not complemented by their orthologs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002198","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL040C"}


id: YDL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C","secondary_identifier":"SGD:S000002199","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL041W"}


id: YDL042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04186":null,"YDL042C":null},"has_protein_features":false,"name":"SIR2","ortholog_annotations":[{"gene_uniquename":"YDL042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04186","reference_uniquename":"PMID:29761456"}],"product":"Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication, suppressing early firing of multicopy rDNA origins; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002200","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL042C"}


id: YDL043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00498":null,"YDL043C":null},"has_protein_features":false,"name":"PRP11","ortholog_annotations":[{"gene_uniquename":"YDL043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00498","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SF3a splicing factor complex; required for spliceosome assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002201","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL043C"}


id: YDL044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01517":null,"YDL044C":null},"has_protein_features":false,"name":"MTF2","ortholog_annotations":[{"gene_uniquename":"YDL044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01517","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein that interacts with mitochondrial RNA polymerase; interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002202","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL044C"}


id: YDL045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01937":null,"YDL045C":null},"has_protein_features":false,"name":"FAD1","ortholog_annotations":[{"gene_uniquename":"YDL045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01937","reference_uniquename":"PMID:29761456"}],"product":"Flavin adenine dinucleotide (FAD) synthetase; performs the second step in synthesis of FAD from riboflavin; mutation is functionally complemented by human FLAD1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002203","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL045C"}


id: YDL045W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01767":null,"YDL045W-A":null},"has_protein_features":false,"name":"MRP10","ortholog_annotations":[{"gene_uniquename":"YDL045W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01767","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs; oxidized by Mia40p during import into mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006430","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL045W-A"}


id: YDL046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01407":null,"YDL046W":null},"has_protein_features":false,"name":"NPC2","ortholog_annotations":[{"gene_uniquename":"YDL046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01407","reference_uniquename":"PMID:29761456"}],"product":"Sterol transport protein, functional homolog of human NPC2 Niemann-Pick disease type C2 protein; together with Ncr1p mediates integration of ergosterol into vacuolar membrane; functions as general “lipid solubilizer”, binds variety of amphiphilic lipid ligands; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; yeast NPC2 can complement mutations in human NPC2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002204","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL046W"}


id: YDL047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01187":null,"YDL047W":null},"has_protein_features":false,"name":"SIT4","ortholog_annotations":[{"gene_uniquename":"YDL047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01187","reference_uniquename":"PMID:29761456"}],"product":"Ceramide-activated, type 2A-related serine-threonine phosphatase; functions in G1/S transition of mitotic cycle; controls lifespan, mitochondrial function, cell cycle progression by regulating HXK2 phosphorylation; regulator of COPII coat dephosphorylation; required for ER to Golgi traffic; interacts with Hrr25p kinase; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization; similar to human PP6","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002205","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL047W"}


id: YDL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STP4","product":"Protein containing a Kruppel-type zinc-finger domain; similar to Stp1p, Stp2p; predicted transcription factor; relative distribution to the nucleus increases upon DNA replication stress; STP4 has a paralog, STP3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002206","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL048C"}


id: YDL049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04073":null,"YDL049C":null},"has_protein_features":false,"name":"KNH1","ortholog_annotations":[{"gene_uniquename":"YDL049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04073","reference_uniquename":"PMID:29761456"}],"product":"Protein with similarity to Kre9p; Kre9p is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002207","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL049C"}


id: YDL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002208","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL050C"}


id: YDL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00195":null,"YDL051W":null},"has_protein_features":false,"name":"LHP1","ortholog_annotations":[{"gene_uniquename":"YDL051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00195","reference_uniquename":"PMID:29761456"}],"product":"RNA binding protein required for maturation of tRNA and U6 snRNA; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002209","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL051W"}


id: YDL052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01957":null,"YDL052C":null},"has_protein_features":false,"name":"SLC1","ortholog_annotations":[{"gene_uniquename":"YDL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01957","reference_uniquename":"PMID:29761456"}],"product":"1-acyl-sn-glycerol-3-phosphate acyltransferase; catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002210","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL052C"}


id: YDL053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PBP4","product":"Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress; also detected in peroxisomes","secondary_identifier":"SGD:S000002211","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL053C"}


id: YDL054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MCH1","product":"Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport","secondary_identifier":"SGD:S000002212","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL054C"}


id: YDL055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03188":null,"YDL055C":null},"has_protein_features":false,"name":"PSA1","ortholog_annotations":[{"gene_uniquename":"YDL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03188","reference_uniquename":"PMID:29761456"}],"product":"GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase); synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002213","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL055C"}


id: YDL056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00693":null,"SJAG_00987":null,"YDL056W":null},"has_protein_features":false,"name":"MBP1","ortholog_annotations":[{"gene_uniquename":"YDL056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00693","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00987","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor; involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002214","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL056W"}


id: YDL057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YDL057W is not an essential gene","secondary_identifier":"SGD:S000002215","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL057W"}


id: YDL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01633":null,"YDL058W":null},"has_protein_features":false,"name":"USO1","ortholog_annotations":[{"gene_uniquename":"YDL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01633","reference_uniquename":"PMID:29761456"}],"product":"Essential protein involved in vesicle-mediated ER to Golgi transport; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002216","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL058W"}


id: YDL059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RAD59","product":"Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; regulates replication fork progression in DNA ligase I-deficient cells; paralog of Rad52p","secondary_identifier":"SGD:S000002217","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL059C"}


id: YDL060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00344":null,"YDL060W":null},"has_protein_features":false,"name":"TSR1","ortholog_annotations":[{"gene_uniquename":"YDL060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00344","reference_uniquename":"PMID:29761456"}],"product":"Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002218","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL060W"}


id: YDL061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03254":null,"YDL061C":null},"has_protein_features":false,"name":"RPS29B","ortholog_annotations":[{"gene_uniquename":"YDL061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03254","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002219","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL061C"}


id: YDL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential","secondary_identifier":"SGD:S000002220","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL062W"}


id: YDL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01621":null,"YDL063C":null},"has_protein_features":false,"name":"SYO1","ortholog_annotations":[{"gene_uniquename":"YDL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01621","reference_uniquename":"PMID:29761456"}],"product":"Transport adaptor or symportin; assembly chaperone that co-translationally associates with nascent Rpl5p, preventing aggregation; facilitates synchronized nuclear coimport of two 5S-rRNA binding proteins, Rpl5p and Rpl11p, mediated by import receptor Kap104p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL063C"}


id: YDL064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02082":null,"YDL064W":null},"has_protein_features":false,"name":"UBC9","ortholog_annotations":[{"gene_uniquename":"YDL064W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02082","reference_uniquename":"PMID:29761456"}],"product":"SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002222","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL064W"}


id: YDL065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03781":null,"YDL065C":null},"has_protein_features":false,"name":"PEX19","ortholog_annotations":[{"gene_uniquename":"YDL065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03781","reference_uniquename":"PMID:29761456"}],"product":"Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL065C"}


id: YDL066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04362":null,"YDL066W":null},"has_protein_features":false,"name":"IDP1","ortholog_annotations":[{"gene_uniquename":"YDL066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04362","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial NADP-specific isocitrate dehydrogenase; catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL066W"}


id: YDL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07007":null,"YDL067C":null},"has_protein_features":false,"name":"COX9","ortholog_annotations":[{"gene_uniquename":"YDL067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07007","reference_uniquename":"PMID:29761456"}],"product":"Subunit VIIa of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002225","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL067C"}


id: YDL068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002226","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL068W"}


id: YDL069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CBS1","product":"Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader","secondary_identifier":"SGD:S000002227","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL069C"}


id: YDL070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02500":null,"SJAG_02701":null,"YDL070W":null},"has_protein_features":false,"name":"BDF2","ortholog_annotations":[{"gene_uniquename":"YDL070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02500","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02701","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress; BDF2 has a paralog, BDF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002228","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL070W"}


id: YDL071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W","secondary_identifier":"SGD:S000002229","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL071C"}


id: YDL072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03244":null,"YDL072C":null},"has_protein_features":false,"name":"YET3","ortholog_annotations":[{"gene_uniquename":"YDL072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03244","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL072C"}


id: YDL073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04503":null,"YDL073W":null},"has_protein_features":false,"name":"AHK1","ortholog_annotations":[{"gene_uniquename":"YDL073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04503","reference_uniquename":"PMID:29761456"}],"product":"Scaffold protein in the HKR1 sub-branch of the Hog1p-signaling pathway; physically interacts with the cytoplasmic domain of Hkr1p, and with Sho1p, Pbs2p, and Ste11p; prevents cross-talk signaling from Hkr1p of the osmotic stress MAPK cascade to the Kss1p MAPK cascade; non-essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL073W"}


id: YDL074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02319":null,"SJAG_03006":null,"YDL074C":null},"has_protein_features":false,"name":"BRE1","ortholog_annotations":[{"gene_uniquename":"YDL074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02319","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03006","reference_uniquename":"PMID:29761456"}],"product":"E3 ubiquitin ligase; forms heterodimer with Rad6p to regulate K63 polyubiquitination in response to oxidative stress and to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control; interacts with RNA-binding protein Npl3p, linking histone ubiquitination to mRNA processing; Bre1p-dependent histone ubiquitination promotes pre-mRNA splicing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL074C"}


id: YDL075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01676":null,"SJAG_02755":null,"YDL075W":null},"has_protein_features":false,"name":"RPL31A","ortholog_annotations":[{"gene_uniquename":"YDL075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01676","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02755","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL075W"}


id: YDL076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00868":null,"YDL076C":null},"has_protein_features":false,"name":"RXT3","ortholog_annotations":[{"gene_uniquename":"YDL076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00868","reference_uniquename":"PMID:29761456"}],"product":"Component of the Rpd3L histone deacetylase complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL076C"}


id: YDL077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05184":null,"YDL077C":null},"has_protein_features":false,"name":"VAM6","ortholog_annotations":[{"gene_uniquename":"YDL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05184","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor for the GTPase Gtr1p; subunit of the HOPS endocytic tethering complex; vacuole membrane protein; functions as a Rab GTPase effector, interacting with both GTP- and GDP-bound conformations of Ypt7p; facilitates tethering and promotes membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; component of vacuole-mitochondrion contacts (vCLAMPs) important for lipid transfer between organelles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL077C"}


id: YDL078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MDH3","product":"Peroxisomal malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle; mutation in human homolog MDH2 causes early-onset severe encephalopathy","secondary_identifier":"SGD:S000002236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL078C"}


id: YDL079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00718":null,"SJAG_05304":null,"YDL079C":null},"has_protein_features":false,"name":"MRK1","ortholog_annotations":[{"gene_uniquename":"YDL079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00718","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05304","reference_uniquename":"PMID:29761456"}],"product":"Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation; MRK1 has a paralog, RIM11, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL079C"}


id: YDL080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02734":null,"SJAG_03743":null,"SJAG_04842":null,"YDL080C":null},"has_protein_features":false,"name":"THI3","ortholog_annotations":[{"gene_uniquename":"YDL080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02734","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03743","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04842","reference_uniquename":"PMID:29761456"}],"product":"Regulatory protein that binds Pdc2p and Thi2p transcription factors; activates thiamine biosynthesis transcription factors Pdc2p and Thi2p by binding to them, but releases and de-activates them upon binding to thiamine pyrophosphate (TPP), the end product of the pathway; has similarity to decarboxylases but enzymatic activity is not detected","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL080C"}


id: YDL081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01411":null,"SJAG_04020":null,"YDL081C":null},"has_protein_features":false,"name":"RPP1A","ortholog_annotations":[{"gene_uniquename":"YDL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01411","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04020","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal stalk protein P1 alpha; involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P1 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL081C"}


id: YDL082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01608":null,"SJAG_03423":null,"YDL082W":null},"has_protein_features":false,"name":"RPL13A","ortholog_annotations":[{"gene_uniquename":"YDL082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03423","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL082W"}


id: YDL083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01609":null,"SJAG_03422":null,"YDL083C":null},"has_protein_features":false,"name":"RPS16B","ortholog_annotations":[{"gene_uniquename":"YDL083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01609","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03422","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL083C"}


id: YDL084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04589":null,"YDL084W":null},"has_protein_features":false,"name":"SUB2","ortholog_annotations":[{"gene_uniquename":"YDL084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04589","reference_uniquename":"PMID:29761456"}],"product":"Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL084W"}


id: YDL085C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04436":null,"YDL085C-A":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDL085C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04436","reference_uniquename":"PMID:29761456"}],"product":"Homolog of modifier of aggregation-4 (MOAG-4) from worm and small EDRK-rich factor protein (SERF1a) from human; highly conserved enhancer of amyloid formation of Aβ40 and α-synuclein both in vitro and in vivo; protein displays very high degree of disorder, segment spanning residues 36E-65K has strong helical propensity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007588","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL085C-A"}


id: YDL085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01539":null,"YDL085W":null},"has_protein_features":false,"name":"NDE2","ortholog_annotations":[{"gene_uniquename":"YDL085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01539","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial external NADH dehydrogenase; catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain; NDE2 has a paralog, NDE1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL085W"}


id: YDL086C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps uncharacterized ORF YDL086W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028611","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL086C-A"}


id: YDL086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene","secondary_identifier":"SGD:S000002244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL086W"}


id: YDL087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04214":null,"YDL087C":null},"has_protein_features":false,"name":"LUC7","ortholog_annotations":[{"gene_uniquename":"YDL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04214","reference_uniquename":"PMID:29761456"}],"product":"Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL087C"}


id: YDL088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03593":null,"YDL088C":null},"has_protein_features":false,"name":"ASM4","ortholog_annotations":[{"gene_uniquename":"YDL088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03593","reference_uniquename":"PMID:29761456"}],"product":"FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL088C"}


id: YDL089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01050":null,"YDL089W":null},"has_protein_features":false,"name":"NUR1","ortholog_annotations":[{"gene_uniquename":"YDL089W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01050","reference_uniquename":"PMID:29761456"}],"product":"Chromosome linkage inner nuclear membrane protein; CLIP, involved in perinuclear chromosome tethering and rDNA repeat stability; involved in regulating mitotic exit; dephosphorylated by Cdc14p in anaphase, which promotes timely rDNA segregation and allows mitotic progression; interacts with Csm1p and Lrs4p; null mutant has elevated levels of unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery; Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL089W"}


id: YDL090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02583":null,"YDL090C":null},"has_protein_features":false,"name":"RAM1","ortholog_annotations":[{"gene_uniquename":"YDL090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02583","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of the CAAX farnesyltransferase (FTase); this complex prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL090C"}


id: YDL091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01585":null,"YDL091C":null},"has_protein_features":false,"name":"UBX3","ortholog_annotations":[{"gene_uniquename":"YDL091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01585","reference_uniquename":"PMID:29761456"}],"product":"Clathrin-coated vesicle component, regulator of endocytosis; copurifies with the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; required for efficient clathrin-mediated endocytosis; ortholog of fission yeast Ucp10","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL091C"}


id: YDL092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01282":null,"YDL092W":null},"has_protein_features":false,"name":"SRP14","ortholog_annotations":[{"gene_uniquename":"YDL092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01282","reference_uniquename":"PMID:29761456"}],"product":"Signal recognition particle (SRP) subunit; interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL092W"}


id: YDL093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04316":null,"YDL093W":null},"has_protein_features":false,"name":"PMT5","ortholog_annotations":[{"gene_uniquename":"YDL093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04316","reference_uniquename":"PMID:29761456"}],"product":"Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL093W"}


id: YDL094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential","secondary_identifier":"SGD:S000002252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL094C"}


id: YDL095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04316":null,"YDL095W":null},"has_protein_features":false,"name":"PMT1","ortholog_annotations":[{"gene_uniquename":"YDL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04316","reference_uniquename":"PMID:29761456"}],"product":"Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; functions as a heterodimer with Pmt2p but can also pair with Pmt3p; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL095W"}


id: YDL096C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OPI6","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential","secondary_identifier":"SGD:S000002254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL096C"}


id: YDL097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00738":null,"YDL097C":null},"has_protein_features":false,"name":"RPN6","ortholog_annotations":[{"gene_uniquename":"YDL097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00738","reference_uniquename":"PMID:29761456"}],"product":"Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL097C"}


id: YDL098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00989":null,"YDL098C":null},"has_protein_features":false,"name":"SNU23","ortholog_annotations":[{"gene_uniquename":"YDL098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00989","reference_uniquename":"PMID:29761456"}],"product":"Component of the U4/U6.U5 snRNP complex; involved in mRNA splicing via spliceosome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL098C"}


id: YDL099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUG1","product":"Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes","secondary_identifier":"SGD:S000002257","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL099W"}


id: YDL100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01240":null,"YDL100C":null},"has_protein_features":false,"name":"GET3","ortholog_annotations":[{"gene_uniquename":"YDL100C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01240","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor for Gpa1p; amplifies G-protein signaling; subunit of the GET complex involved in ATP-dependent Golgi-to-ER trafficking; binds as a dimer to the transmembrane domain of tail-anchored proteins in the cytosol, shielding them from aqueous solvent until the Get1p/Get2p heterodimer releases the substrate and inserts it into the ER membrane; acts as a chaperone under ATP-depleted oxidative stress conditions; protein abundance increases under DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002258","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL100C"}


id: YDL101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DUN1","product":"Cell-cycle checkpoint S/T protein kinase; required for transient G2/M arrest after DNA damage, damage-induced transcription, and nuclear-to-cytoplasmic redistribution of Rnr2p-Rnr4p after genotoxic stress and iron deprivation; phosphorylates repair protein Rad55p, transcriptional repressor Sml1p, superoxide dismutase, and ribonucleotide reductase inhibitors Crt1p and Dif1p; functions in the Mec1p pathway to regulate dNTP pools and telomere length; postreplicative repair role","secondary_identifier":"SGD:S000002259","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL101C"}


id: YDL102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02818":null,"YDL102W":null},"has_protein_features":false,"name":"POL3","ortholog_annotations":[{"gene_uniquename":"YDL102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02818","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of DNA polymerase delta; responsible for most of lagging strand DNA synthesis; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002260","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL102W"}


id: YDL103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01443":null,"YDL103C":null},"has_protein_features":false,"name":"QRI1","ortholog_annotations":[{"gene_uniquename":"YDL103C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01443","reference_uniquename":"PMID:29761456"}],"product":"UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002261","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL103C"}


id: YDL104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00865":null,"YDL104C":null},"has_protein_features":false,"name":"QRI7","ortholog_annotations":[{"gene_uniquename":"YDL104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00865","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; highly conserved mitochondrial protein; essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification; when directed to the cytoplasm, complements the essential function of Kae1p in the KEOPS complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002262","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL104C"}


id: YDL105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01332":null,"YDL105W":null},"has_protein_features":false,"name":"NSE4","ortholog_annotations":[{"gene_uniquename":"YDL105W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01332","reference_uniquename":"PMID:29761456"}],"product":"Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002263","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL105W"}


id: YDL106C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05006":null,"YDL106C":null},"has_protein_features":false,"name":"PHO2","ortholog_annotations":[{"gene_uniquename":"YDL106C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05006","reference_uniquename":"PMID:26896847"}],"product":"Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000002264","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL106C"}


id: YDL107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MSS2","product":"Peripherally bound inner membrane protein of the mitochondrial matrix; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p","secondary_identifier":"SGD:S000002265","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL107W"}


id: YDL108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00150":null,"YDL108W":null},"has_protein_features":false,"name":"KIN28","ortholog_annotations":[{"gene_uniquename":"YDL108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00150","reference_uniquename":"PMID:29761456"}],"product":"Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly; phosphorylates the C-terminal domain (CTD) of RNAPII (Ser5 and Ser7); facilitates recruitment of mRNA 5'-capping and polyadenylation factors to the RNAPII holoenzyme complex; minor role in RNAPII transcription; role in RNAPI transcription; regulates Atg1p kinase complex assembly during nitrogen starvation induced autophagy; associates with cyclin Ccl1p; relocalizes to the cytosol in response to hypoxia; ortholog of human CDK7","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002266","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL108W"}


id: YDL109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04105":null,"SJAG_04973":null,"YDL109C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDL109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04105","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YDL109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04973","reference_uniquename":"PMID:29761456"}],"product":"Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002267","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL109C"}


id: YDL110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TMA17","product":"Regulatory gamma subunit of fatty acid synthase (FAS); ATPase dedicated chaperone that adapts proteasome assembly to stress; induced upon stress; interacts with Rpt6p to assist its pairing to Rpt3p and early steps in proteasome biogenesis; associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion","secondary_identifier":"SGD:S000002268","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL110C"}


id: YDL111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04818":null,"YDL111C":null},"has_protein_features":false,"name":"RRP42","ortholog_annotations":[{"gene_uniquename":"YDL111C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04818","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002269","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL111C"}


id: YDL112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TRM3","product":"2'-O-ribose methyltransferase; catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs","secondary_identifier":"SGD:S000002270","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL112W"}


id: YDL113C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04219":null,"YDL113C":null},"has_protein_features":false,"name":"ATG20","ortholog_annotations":[{"gene_uniquename":"YDL113C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04219","reference_uniquename":"PMID:29761456"}],"product":"Sorting nexin family member; required for the cytoplasm-to-vacuole targeting (Cvt) pathway, endosomal sorting and selective autophagy; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002271","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL113C"}


id: YDL114W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00593":null,"YDL114W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDL114W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00593","reference_uniquename":"PMID:29761456"}],"product":"Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002272","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL114W"}


id: YDL114W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified based on homology to hemiascomycetous yeasts","secondary_identifier":"SGD:S000007598","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL114W-A"}


id: YDL115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00383":null,"YDL115C":null},"has_protein_features":false,"name":"IWR1","ortholog_annotations":[{"gene_uniquename":"YDL115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00383","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002273","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL115C"}


id: YDL116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04148":null,"YDL116W":null},"has_protein_features":false,"name":"NUP84","ortholog_annotations":[{"gene_uniquename":"YDL116W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04148","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002274","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL116W"}


id: YDL117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03379":null,"YDL117W":null},"has_protein_features":false,"name":"CYK3","ortholog_annotations":[{"gene_uniquename":"YDL117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03379","reference_uniquename":"PMID:29761456"}],"product":"SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002275","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL117W"}


id: YDL118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein","secondary_identifier":"SGD:S000002276","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL118W"}


id: YDL119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04984":null,"YDL119C":null},"has_protein_features":false,"name":"HEM25","ortholog_annotations":[{"gene_uniquename":"YDL119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04984","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial glycine transporter; required for the transport of glycine into mitochondria for initiation of heme biosynthesis, with YMC1 acting as a secondary transporter; homolog of human SLC25A38, a mitochondrial glycine transporter associated with nonsyndromic autosomal recessive congenital sideroblastic anemia; human SLC25A38 can complement the heme deficiency associated with the null mutant; GFP-fusion protein is induced in response to the DNA-damaging agent MMS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002277","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL119C"}


id: YDL120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03862":null,"YDL120W":null},"has_protein_features":false,"name":"YFH1","ortholog_annotations":[{"gene_uniquename":"YDL120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03862","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog FXN is mutated in Friedrich's ataxia; human FTL gene can complement yeast yfh1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002278","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL120W"}


id: YDL121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EXP1","product":"A cargo receptor protein for Pma1p; works with Psg1p to promote the transport and maturation of Pma1p; localizes to the ER and COPII vesicles; a non-essential protein","secondary_identifier":"SGD:S000002279","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL121C"}


id: YDL122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UBP1","product":"Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains","secondary_identifier":"SGD:S000002280","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL122W"}


id: YDL123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00372":null,"YDL123W":null},"has_protein_features":false,"name":"SNA4","ortholog_annotations":[{"gene_uniquename":"YDL123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00372","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; localized to the vacuolar outer membrane; predicted to be palmitoylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002281","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL123W"}


id: YDL124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01869":null,"YDL124W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDL124W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01869","reference_uniquename":"PMID:29761456"}],"product":"NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002282","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL124W"}


id: YDL125C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01231":null,"YDL125C":null},"has_protein_features":false,"name":"HNT1","ortholog_annotations":[{"gene_uniquename":"YDL125C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01231","reference_uniquename":"PMID:29761456"}],"product":"Adenosine 5'-monophosphoramidase; interacts physically and genetically with CDK and TFIIK subunit Kin28p, and genetically with CAK1; member of histidine triad (HIT) superfamily of nucleotide-binding proteins; protein abundance increases in response to DNA replication stress; human homolog HINT1 can complement yeast hnt1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002283","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL125C"}


id: YDL126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03345":null,"YDL126C":null},"has_protein_features":false,"name":"CDC48","ortholog_annotations":[{"gene_uniquename":"YDL126C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03345","reference_uniquename":"PMID:29761456"}],"product":"AAA ATPase with protein-unfoldase activity; subunit of polyUb-selective segregase complex involved in ERAD, INM-associated degradation (INMAD), mitotic spindle disassembly, macroautophagy, PMN, ribosome-associated degradation, ribophagy, homotypic ER membrane fusion, SCF complex disassembly, cell wall integrity, and telomerase regulation; mobilizes membrane-anchored transcription factors by regulated Ub/proteasome-dependent processing (RUP); human ortholog VCP complements a cdc48 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002284","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL126C"}


id: YDL127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PCL2","product":"Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth; PCL2 has a paralog, PCL9, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002285","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL127W"}


id: YDL128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04698":null,"YDL128W":null},"has_protein_features":false,"name":"VCX1","ortholog_annotations":[{"gene_uniquename":"YDL128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04698","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity; involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002286","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL128W"}


id: YDL129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000002287","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL129W"}


id: YDL130W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01411":null,"SJAG_04020":null,"YDL130W":null},"has_protein_features":false,"name":"RPP1B","ortholog_annotations":[{"gene_uniquename":"YDL130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01411","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04020","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein P1 beta; component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; free (non-ribosomal) P1 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; accumulation is regulated by phosphorylation and interaction with the P2 stalk component","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002288","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL130W"}


id: YDL130W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04422":null,"YDL130W-A":null},"has_protein_features":false,"name":"STF1","ortholog_annotations":[{"gene_uniquename":"YDL130W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04422","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress; STF1 has a paralog, INH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL130W-A"}


id: YDL131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04688":null,"YDL131W":null},"has_protein_features":false,"name":"LYS21","ortholog_annotations":[{"gene_uniquename":"YDL131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04688","reference_uniquename":"PMID:29761456"}],"product":"Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002289","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL131W"}


id: YDL132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02591":null,"YDL132W":null},"has_protein_features":false,"name":"CDC53","ortholog_annotations":[{"gene_uniquename":"YDL132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02591","reference_uniquename":"PMID:29761456"}],"product":"Cullin; structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; human homolog CUL1 can complement yeast cdc53 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002290","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL132W"}


id: YDL133C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07013":null,"SJAG_07014":null,"YDL133C-A":null},"has_protein_features":false,"name":"RPL41B","ortholog_annotations":[{"gene_uniquename":"YDL133C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07013","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDL133C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07014","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002293","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDL133C-A"}


