# genes

id: YNL292W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04065":null,"YNL292W":null},"has_protein_features":false,"name":"PUS4","ortholog_annotations":[{"gene_uniquename":"YNL292W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04065","reference_uniquename":"PMID:29761456"}],"product":"Pseudouridine synthase; catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; also responsible for pseudouracil modification of some mRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL292W"}


id: YNL293W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01048":null,"YNL293W":null},"has_protein_features":false,"name":"MSB3","ortholog_annotations":[{"gene_uniquename":"YNL293W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01048","reference_uniquename":"PMID:29761456"}],"product":"Rab GTPase-activating protein; regulates endocytosis via inactivation of Vps21p at endosomes and vacuole fusion via inactivation of Ypt7p at vacuoles; also acts on Ypt52p and Sec4p; localizes to plasma membrane, sites of polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; similar to TBC-domain Tre2 oncogene; MSB3 has a paralog, MSB4, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL293W"}


id: YNL294C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RIM21","product":"pH sensor molecule, component of RIM101 pathway; positive regulator of cell size; has role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH","secondary_identifier":"SGD:S000005238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL294C"}


id: YNL295W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00077":null,"YNL295W":null},"has_protein_features":false,"name":"MRX6","ortholog_annotations":[{"gene_uniquename":"YNL295W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00077","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosome-associated protein; regulates mitochondrial DNA copy number and the size and distribution of mtDNA nucleoids; subunit of a complex containing Pet20p, Mam33p, and Pim1p that may regulate mtDNA replication; member of the PET20 domain-containing protein family; forms foci that partially co-localize with mtDNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL295W"}


id: YNL296W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog","secondary_identifier":"SGD:S000005240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL296W"}


id: YNL297C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01030":null,"YNL297C":null},"has_protein_features":false,"name":"MON2","ortholog_annotations":[{"gene_uniquename":"YNL297C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01030","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in endocytosis and vacuole integrity; peripheral membrane protein; interacts with and negatively regulates Arl1p; localizes to the endosome; member of the Sec7p family of proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL297C"}


id: YNL298W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CLA4","product":"Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL298W"}


id: YNL299W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01176":null,"YNL299W":null},"has_protein_features":false,"name":"TRF5","ortholog_annotations":[{"gene_uniquename":"YNL299W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01176","reference_uniquename":"PMID:29761456"}],"product":"Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL299W"}


id: YNL300W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TOS6","product":"Glycosylphosphatidylinositol-dependent cell wall protein; expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid","secondary_identifier":"SGD:S000005244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL300W"}


id: YNL301C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02597":null,"SJAG_03335":null,"YNL301C":null},"has_protein_features":false,"name":"RPL18B","ortholog_annotations":[{"gene_uniquename":"YNL301C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02597","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL301C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03335","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL301C"}


id: YNL302C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01296":null,"SJAG_02335":null,"YNL302C":null},"has_protein_features":false,"name":"RPS19B","ortholog_annotations":[{"gene_uniquename":"YNL302C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL302C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02335","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19B has a paralog, RPS19A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL302C"}


id: YNL303W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL303W"}


id: YNL304W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YPT11","product":"Rab GTPase; Myo2p-binding protein implicated in mother-to-bud transport of cortical endoplasmic reticulum (ER), late Golgi, and mitochondria during cell division; function is regulated at multiple levels; abundance of active Ypt11p forms is controlled by phosphorylation status and degradation; normally a low-abundance protein whose ER localization is only detected when protein is highly over expressed","secondary_identifier":"SGD:S000005248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL304W"}


id: YNL305C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04471":null,"YNL305C":null},"has_protein_features":false,"name":"BXI1","ortholog_annotations":[{"gene_uniquename":"YNL305C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04471","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL305C"}


id: YNL306W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02777":null,"YNL306W":null},"has_protein_features":false,"name":"MRPS18","ortholog_annotations":[{"gene_uniquename":"YNL306W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02777","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL306W"}


id: YNL307C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00718":null,"SJAG_05304":null,"YNL307C":null},"has_protein_features":false,"name":"MCK1","ortholog_annotations":[{"gene_uniquename":"YNL307C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00718","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL307C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05304","reference_uniquename":"PMID:29761456"}],"product":"Dual-specificity S/T and tyrosine protein kinase; spindle position checkpoint component that works in parallel with Kin4p to prevent mitotic exit network (MEN) activation by the Cdc14 early anaphase release (FEAR) network; roles in chromosome segregation, meiotic entry, genome stability, phosphorylation-dependent degradation of Rcn1p and Cdc6p, inhibition of protein kinase A, transcriptional regulation, inhibition of RNAPIII, calcium stress and inhibition of Clb2p-Cdc28p after nuclear division","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL307C"}


id: YNL308C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00965":null,"YNL308C":null},"has_protein_features":false,"name":"KRI1","ortholog_annotations":[{"gene_uniquename":"YNL308C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00965","reference_uniquename":"PMID:29761456"}],"product":"Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL308C"}


id: YNL309W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STB1","product":"Protein with role in regulation of MBF-specific transcription at Start; phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p, which is required for Stb1p function; expression is cell-cycle regulated; STB1 has a paralog, YOL131W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL309W"}


id: YNL310C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04336":null,"YNL310C":null},"has_protein_features":false,"name":"ZIM17","ortholog_annotations":[{"gene_uniquename":"YNL310C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04336","reference_uniquename":"PMID:29761456"}],"product":"Protein co-chaperone with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix; required for the maintenance of Ssc1p solubility and assists in the functional interaction of Ssc1p with substrate proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL310C"}


id: YNL311C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SKP2","product":"F-box protein of unknown function; predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments","secondary_identifier":"SGD:S000005255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL311C"}


id: YNL312W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01698":null,"YNL312W":null},"has_protein_features":false,"name":"RFA2","ortholog_annotations":[{"gene_uniquename":"YNL312W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01698","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; in concert with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication s","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL312W"}


id: YNL313C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01291":null,"YNL313C":null},"has_protein_features":false,"name":"EMW1","ortholog_annotations":[{"gene_uniquename":"YNL313C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01291","reference_uniquename":"PMID:29761456"}],"product":"Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005257","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL313C"}


id: YNL314W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DAL82","product":"Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain","secondary_identifier":"SGD:S000005258","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL314W"}


id: YNL315C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04899":null,"YNL315C":null},"has_protein_features":false,"name":"ATP11","ortholog_annotations":[{"gene_uniquename":"YNL315C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04899","reference_uniquename":"PMID:29761456"}],"product":"Molecular chaperone; required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; N-terminally propionylated in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005259","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL315C"}


id: YNL316C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03124":null,"YNL316C":null},"has_protein_features":false,"name":"PHA2","ortholog_annotations":[{"gene_uniquename":"YNL316C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03124","reference_uniquename":"PMID:29761456"}],"product":"Prephenate dehydratase; catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005260","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL316C"}


id: YNL317W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01175":null,"YNL317W":null},"has_protein_features":false,"name":"PFS2","ortholog_annotations":[{"gene_uniquename":"YNL317W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01175","reference_uniquename":"PMID:29761456"}],"product":"Integral subunit of the pre-mRNA CPF complex; the cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005261","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL317W"}


id: YNL318C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04905":null,"YNL318C":null},"has_protein_features":false,"name":"HXT14","ortholog_annotations":[{"gene_uniquename":"YNL318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL318C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Protein with similarity to hexose transporter family members; expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005262","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL318C"}


id: YNL319W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HXT14","secondary_identifier":"SGD:S000005263","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL319W"}


id: YNL320W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00774":null,"YNL320W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNL320W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00774","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005264","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL320W"}


id: YNL321W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04028":null,"YNL321W":null},"has_protein_features":false,"name":"VNX1","ortholog_annotations":[{"gene_uniquename":"YNL321W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04028","reference_uniquename":"PMID:29761456"}],"product":"Calcium/H+ antiporter localized to endoplasmic reticulum membrane; member of calcium exchanger (CAX) family; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005265","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL321W"}


id: YNL322C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"KRE1","product":"Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor","secondary_identifier":"SGD:S000005266","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL322C"}


id: YNL323W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02516":null,"SJAG_03050":null,"YNL323W":null},"has_protein_features":false,"name":"LEM3","ortholog_annotations":[{"gene_uniquename":"YNL323W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02516","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNL323W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03050","reference_uniquename":"PMID:29761456"}],"product":"Membrane protein of the plasma membrane and ER; interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane; null mutant requires tryptophan due to mislocalization of tryptophan permease Tat2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005267","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL323W"}


id: YNL324W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005268","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL324W"}


id: YNL325C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02289":null,"YNL325C":null},"has_protein_features":false,"name":"FIG4","ortholog_annotations":[{"gene_uniquename":"YNL325C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02289","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain; homologous to human FIG4, which is associated with CMT4J, a form of Charcot-Marie-Tooth disorder","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005269","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL325C"}


id: YNL326C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01299":null,"YNL326C":null},"has_protein_features":false,"name":"PFA3","ortholog_annotations":[{"gene_uniquename":"YNL326C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01299","reference_uniquename":"PMID:29761456"}],"product":"Palmitoyltransferase for Vac8p; required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005270","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL326C"}


id: YNL327W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EGT2","product":"Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase; localizes in birth scars; required for proper cell separation after cytokinesis; expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner","secondary_identifier":"SGD:S000005271","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL327W"}


id: YNL328C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01597":null,"YNL328C":null},"has_protein_features":false,"name":"MDJ2","ortholog_annotations":[{"gene_uniquename":"YNL328C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01597","reference_uniquename":"PMID:29761456"}],"product":"Constituent of the mitochondrial import motor; associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005272","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL328C"}


id: YNL329C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02997":null,"YNL329C":null},"has_protein_features":false,"name":"PEX6","ortholog_annotations":[{"gene_uniquename":"YNL329C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02997","reference_uniquename":"PMID:29761456"}],"product":"AAA-peroxin; heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; mutations in human PEX6 can lead to severe peroxisomal disorders and early death","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005273","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL329C"}


id: YNL330C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00581":null,"YNL330C":null},"has_protein_features":false,"name":"RPD3","ortholog_annotations":[{"gene_uniquename":"YNL330C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00581","reference_uniquename":"PMID:29761456"}],"product":"Histone deacetylase, component of both Rpd3S and Rpd3L complexes; regulates transcription, silencing, autophagy and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; Rpd3(L) recruitment to the subtelomeric region is regulated by interaction with the Hmt1p methyltransferase; delays late firing of single copy origins by opposing the Fkh1/2 origin activation pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005274","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL330C"}


id: YNL331C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AAD14","product":"Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family","secondary_identifier":"SGD:S000005275","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL331C"}


id: YNL332W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04866":null,"YNL332W":null},"has_protein_features":false,"name":"THI12","ortholog_annotations":[{"gene_uniquename":"YNL332W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04866","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005276","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL332W"}


id: YNL333W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00283":null,"YNL333W":null},"has_protein_features":false,"name":"SNZ2","ortholog_annotations":[{"gene_uniquename":"YNL333W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00283","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in thiamine and pyridoxine biosynthesis; member of a stationary phase-induced gene family where transcriptional induction precedes the diauxic shift; induced in the absence of thiamin in a Thi2/3p-dependent manner and repressed in its presence; forms a co-regulated gene pair with SNO2; interacts with Thi11p; paralog of SNZ1 and SNZ3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005277","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL333W"}


id: YNL334C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00691":null,"YNL334C":null},"has_protein_features":false,"name":"SNO2","ortholog_annotations":[{"gene_uniquename":"YNL334C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00691","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005278","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL334C"}


id: YNL335W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DDI2","product":"Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI3 and Ddi3p","secondary_identifier":"SGD:S000005279","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL335W"}


id: YNL336W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS1","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000005280","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL336W"}


id: YNL337W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005281","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL337W"}


id: YNL338W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is a telomeric X element core sequence on the left arm of chromosome XIV","secondary_identifier":"SGD:S000005282","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL338W"}


id: YNL339C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YRF1-6","product":"Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p","secondary_identifier":"SGD:S000005283","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL339C"}


id: YNL339W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028703","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL339W-A"}


id: YNL339W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNL339W-B"}


id: YNR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01922":null,"YNR001C":null},"has_protein_features":false,"name":"CIT1","ortholog_annotations":[{"gene_uniquename":"YNR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01922","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial citrate synthase; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate, which is the first and rate-limiting step of the TCA cycle; transcription subject to glucose repression; CIT1 has a paralog, CIT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005284","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR001C"}


id: YNR001W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by homology","secondary_identifier":"SGD:S000007625","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR001W-A"}


id: YNR002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01505":null,"YNR002C":null},"has_protein_features":false,"name":"ATO2","ortholog_annotations":[{"gene_uniquename":"YNR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01505","reference_uniquename":"PMID:29761456"}],"product":"Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005285","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR002C"}


id: YNR003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03181":null,"YNR003C":null},"has_protein_features":false,"name":"RPC34","ortholog_annotations":[{"gene_uniquename":"YNR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03181","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005286","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR003C"}


id: YNR003W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene RPC34/YNR003C","secondary_identifier":"SGD:S000028705","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR003W-A"}


id: YNR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SWM2","product":"Protein with a role in snRNA and snoRNA cap trimethylation; interacts with Tgs1p and shows similar phenotypes; required for trimethylation of the caps of spliceosomal snRNAs and the U3 snoRNA, and for efficient 3' end processing of U3 snoRNA; may act as a specificity factor for Tgs1p","secondary_identifier":"SGD:S000005287","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR004W"}


id: YNR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005288","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR005C"}


id: YNR006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03250":null,"YNR006W":null},"has_protein_features":false,"name":"VPS27","ortholog_annotations":[{"gene_uniquename":"YNR006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03250","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin binding protein involved in endosomal protein sorting; K48-, K63-Ub chain binding protein that preferentially binds K63-linked chains in vitro; subunit of the ESCRT-0 complex that binds to ubiquitin via two ubiquitin-interacting motifs (UIMs) and is involved in sorting cargo into multivesicular bodies; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005289","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR006W"}


id: YNR007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01561":null,"YNR007C":null},"has_protein_features":false,"name":"ATG3","ortholog_annotations":[{"gene_uniquename":"YNR007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01561","reference_uniquename":"PMID:29761456"}],"product":"E2-like enzyme; involved in autophagy and cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p regulated by acetylation by NuA4 histone acetyltransferase Esa1p while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p; Atg12p-Atg5p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005290","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR007C"}


id: YNR008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03162":null,"YNR008W":null},"has_protein_features":false,"name":"LRO1","ortholog_annotations":[{"gene_uniquename":"YNR008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03162","reference_uniquename":"PMID:29761456"}],"product":"Acyltransferase that converts diacylglycerol to triacylglycerol (TGA); one of several acyltransferases that contribute to TGA synthesis; relocates from ER to nuclear membrane in response cell cycle and starvation signals; Lro1p and Dga1p can O-acylate ceramides; putative homolog of human lecithin cholesterol acyltransferase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005291","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR008W"}


id: YNR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04381":null,"YNR009W":null},"has_protein_features":false,"name":"NRM1","ortholog_annotations":[{"gene_uniquename":"YNR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04381","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional co-repressor of MBF-regulated gene expression; Nrm1p associates stably with promoters via MCB binding factor (MBF) to repress transcription upon exit from G1 phase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005292","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR009W"}


id: YNR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03590":null,"YNR010W":null},"has_protein_features":false,"name":"CSE2","ortholog_annotations":[{"gene_uniquename":"YNR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03590","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Middle domain of mediator; required for regulation of RNA polymerase II activity; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005293","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR010W"}


id: YNR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01315":null,"YNR011C":null},"has_protein_features":false,"name":"PRP2","ortholog_annotations":[{"gene_uniquename":"YNR011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01315","reference_uniquename":"PMID:29761456"}],"product":"RNA-dependent DExD/H-box ATPase; required for activation of spliceosome before first transesterification step in RNA splicing; implicated in rearranging and proofreading snRNA structure in catalytic activation of spliceosome; ortholog of human protein DHX16","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005294","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR011C"}


id: YNR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03708":null,"YNR012W":null},"has_protein_features":false,"name":"URK1","ortholog_annotations":[{"gene_uniquename":"YNR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03708","reference_uniquename":"PMID:29761456"}],"product":"Uridine/cytidine kinase; component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005295","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR012W"}


id: YNR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01059":null,"YNR013C":null},"has_protein_features":false,"name":"PHO91","ortholog_annotations":[{"gene_uniquename":"YNR013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01059","reference_uniquename":"PMID:29761456"}],"product":"Low-affinity vacuolar phosphate transporter; exports phosphate from vacuolar lumen to cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of PHO pathway; localizes to sites of contact between vacuole and mitochondria (vCLAMPs); targeted to vacuole via AP-3 pathway; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005296","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR013C"}


id: YNR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005297","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR014W"}


id: YNR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03236":null,"YNR015W":null},"has_protein_features":false,"name":"SMM1","ortholog_annotations":[{"gene_uniquename":"YNR015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03236","reference_uniquename":"PMID:29761456"}],"product":"Dihydrouridine synthase; member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of the D loop of cytoplasmic pre-tRNAs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005298","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR015W"}


id: YNR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03313":null,"YNR016C":null},"has_protein_features":false,"name":"ACC1","ortholog_annotations":[{"gene_uniquename":"YNR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03313","reference_uniquename":"PMID:29761456"}],"product":"Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availability of acetyl-CoA; rate-limiting step for de novo biosynthesis of long-chain fatty acids; translational regulation in response to nutrients and cell cycle stage depends on its upstream ORF; ACC1 has a paralog, HFA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005299","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR016C"}


id: YNR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04218":null,"YNR017W":null},"has_protein_features":false,"name":"TIM23","ortholog_annotations":[{"gene_uniquename":"YNR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04218","reference_uniquename":"PMID:29761456"}],"product":"Essential core component of the TIM23 complex; subunit of the translocase of the inner mitochondrial membrane involved in protein import into the mitochondrial matrix and inner membrane; provides a structural role, contributing to the architecture of the import channel; functions as a voltage sensor and pre-sequence receptor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005300","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR017W"}


id: YNR018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03337":null,"YNR018W":null},"has_protein_features":false,"name":"RCF2","ortholog_annotations":[{"gene_uniquename":"YNR018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03337","reference_uniquename":"PMID:29761456"}],"product":"Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; antagonistic with Min8p to control ETC assembly member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005301","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR018W"}


id: YNR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04049":null,"SJAG_04059":null,"YNR019W":null},"has_protein_features":false,"name":"ARE2","ortholog_annotations":[{"gene_uniquename":"YNR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04049","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04059","reference_uniquename":"PMID:29761456"}],"product":"Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005302","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR019W"}


id: YNR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01838":null,"YNR020C":null},"has_protein_features":false,"name":"ATP23","ortholog_annotations":[{"gene_uniquename":"YNR020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01838","reference_uniquename":"PMID:29761456"}],"product":"Putative metalloprotease of the mitochondrial inner membrane; required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005303","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR020C"}


id: YNR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03930":null,"YNR021W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03930","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005304","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR021W"}


id: YNR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04207":null,"YNR022C":null},"has_protein_features":false,"name":"MRPL50","ortholog_annotations":[{"gene_uniquename":"YNR022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04207","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005305","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR022C"}


id: YNR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00739":null,"YNR023W":null},"has_protein_features":false,"name":"SNF12","ortholog_annotations":[{"gene_uniquename":"YNR023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00739","reference_uniquename":"PMID:29761456"}],"product":"73 kDa subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive; SNF12 has a paralog, RSC6, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005306","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR023W"}


id: YNR024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01431":null,"YNR024W":null},"has_protein_features":false,"name":"MPP6","ortholog_annotations":[{"gene_uniquename":"YNR024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01431","reference_uniquename":"PMID:29761456"}],"product":"Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005307","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR024W"}


id: YNR025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase","secondary_identifier":"SGD:S000005308","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR025C"}


id: YNR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04615":null,"YNR026C":null},"has_protein_features":false,"name":"SEC12","ortholog_annotations":[{"gene_uniquename":"YNR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04615","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF); activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER; SEC12 has a paralog, SED4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005309","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR026C"}


id: YNR027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00252":null,"SJAG_01383":null,"YNR027W":null},"has_protein_features":false,"name":"BUD17","ortholog_annotations":[{"gene_uniquename":"YNR027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00252","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01383","reference_uniquename":"PMID:29761456"}],"product":"Putative pyridoxal kinase; a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005310","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR027W"}


id: YNR028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CPR8","product":"Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; CPR8 has a paralog, CPR4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005311","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR028W"}


id: YNR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00923":null,"YNR029C":null},"has_protein_features":false,"name":"ZNG1","ortholog_annotations":[{"gene_uniquename":"YNR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00923","reference_uniquename":"PMID:29761456"}],"product":"GTP-dependent zinc transferase; couples GTP hydrolysis to the activation of methionine aminopeptidase Map1p, especially during zinc starvation; deletion confers reduced fitness in saline; contains GTPase sequence motifs and a CxCC metal-binding motif","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005312","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR029C"}


id: YNR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00437":null,"YNR030W":null},"has_protein_features":false,"name":"ALG12","ortholog_annotations":[{"gene_uniquename":"YNR030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00437","reference_uniquename":"PMID:29761456"}],"product":"Alpha-1,6-mannosyltransferase localized to the ER; responsible for addition of alpha-1,6 mannose to dolichol-linked Man7GlcNAc2; acts in the dolichol pathway for N-glycosylation; human homolog ALG12 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005313","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR030W"}


id: YNR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03384":null,"SJAG_04777":null,"YNR031C":null},"has_protein_features":false,"name":"SSK2","ortholog_annotations":[{"gene_uniquename":"YNR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03384","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04777","reference_uniquename":"PMID:29761456"}],"product":"MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress; a HOG-independent function of Ssk2p mediates the calcium-sensitive phenotype of the ptp2 msg5 double disruptant; SSK2 has a paralog, SSK22, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005314","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR031C"}


id: YNR032C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03849":null,"YNR032C-A":null},"has_protein_features":false,"name":"HUB1","ortholog_annotations":[{"gene_uniquename":"YNR032C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03849","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR032C-A"}


id: YNR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01790":null,"YNR032W":null},"has_protein_features":false,"name":"PPG1","ortholog_annotations":[{"gene_uniquename":"YNR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01790","reference_uniquename":"PMID:29761456"}],"product":"Serine protein phosphatase involved in formation of FAR complex; inhibits mitophagy by dephosphorylating Atg32p; required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005315","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR032W"}


id: YNR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02408":null,"YNR033W":null},"has_protein_features":false,"name":"ABZ1","ortholog_annotations":[{"gene_uniquename":"YNR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02408","reference_uniquename":"PMID:29761456"}],"product":"Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005316","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR033W"}


id: YNR034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01824":null,"YNR034W":null},"has_protein_features":false,"name":"SOL1","ortholog_annotations":[{"gene_uniquename":"YNR034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01824","reference_uniquename":"PMID:29761456"}],"product":"Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005317","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR034W"}


id: YNR034W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EGO4","product":"Protein of unknown function; expressed during diauxic shift and stationary phase, and negatively regulated by glucose; expression is regulated by Msn2p/Msn4p; overexpression slows down progression through meiosis and improves fermentative efficiency; YNR034W-A has a paralog, YCR075W-A, that arose from the whole genome duplication","secondary_identifier":"SGD:S000007525","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR034W-A"}


id: YNR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01384":null,"YNR035C":null},"has_protein_features":false,"name":"ARC35","ortholog_annotations":[{"gene_uniquename":"YNR035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01384","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005318","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR035C"}


id: YNR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04173":null,"SJAG_04494":null,"YNR036C":null},"has_protein_features":false,"name":"MRPS12","ortholog_annotations":[{"gene_uniquename":"YNR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04173","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04494","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005319","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR036C"}


id: YNR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04918":null,"YNR037C":null},"has_protein_features":false,"name":"RSM19","ortholog_annotations":[{"gene_uniquename":"YNR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04918","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S19 ribosomal protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005320","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR037C"}


id: YNR038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03479":null,"YNR038W":null},"has_protein_features":false,"name":"DBP6","ortholog_annotations":[{"gene_uniquename":"YNR038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03479","reference_uniquename":"PMID:29761456"}],"product":"Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family; human homolog DDX51 complements yeast dbp6 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005321","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR038W"}


id: YNR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03528":null,"YNR039C":null},"has_protein_features":false,"name":"ZRG17","ortholog_annotations":[{"gene_uniquename":"YNR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03528","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005322","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR039C"}


id: YNR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRX15","product":"Membrane-associated mitoribosome receptor; involved along with Mba1p in the cotranslational insertion of nascent polypeptide chains into the inner mitochondrial membrane; associates with the mitochondrial large ribosomal subunit and nascent polypeptide chains; null mutant displays increased tolerance to mistranslation-induced proteotoxic stress; localizes to the inner mitochondrial membrane","secondary_identifier":"SGD:S000005323","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR040W"}


id: YNR041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06603":null,"YNR041C":null},"has_protein_features":false,"name":"COQ2","ortholog_annotations":[{"gene_uniquename":"YNR041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06603","reference_uniquename":"PMID:29761456"}],"product":"Para hydroxybenzoate polyprenyl transferase; catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis; human COQ2, mutations in which are implicated in an increased risk of mutiple-system atrophy, can complement a yeast coq2 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005324","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR041C"}


id: YNR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2","secondary_identifier":"SGD:S000005325","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR042W"}


id: YNR043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03349":null,"YNR043W":null},"has_protein_features":false,"name":"MVD1","ortholog_annotations":[{"gene_uniquename":"YNR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03349","reference_uniquename":"PMID:29761456"}],"product":"Mevalonate pyrophosphate decarboxylase; essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005326","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR043W"}


id: YNR044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AGA1","product":"Anchorage subunit of a-agglutinin of a-cells; highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds; AGA1 has a paralog, FIG2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005327","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR044W"}


id: YNR045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PET494","product":"Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane","secondary_identifier":"SGD:S000005328","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR045W"}


id: YNR046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04890":null,"YNR046W":null},"has_protein_features":false,"name":"TRM112","ortholog_annotations":[{"gene_uniquename":"YNR046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04890","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in methylation of tRNA, rRNA, and translation factors; also involved in ribosome biogenesis; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; N7-methylates G1575 of 18S rRNA as complex with Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; relative distribution to the nucleus increases upon DNA replication stress; functional homolog of human TRMT112","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005329","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR046W"}


id: YNR047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03209":null,"SJAG_04734":null,"YNR047W":null},"has_protein_features":false,"name":"FPK1","ortholog_annotations":[{"gene_uniquename":"YNR047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03209","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04734","reference_uniquename":"PMID:29761456"}],"product":"Ser/Thr protein kinase; phosphorylates several aminophospholipid translocase family members, regulating phospholipid translocation and membrane asymmetry; phosphorylates and inhibits the protein kinase Akl1p, stimulating endocytosis; phosphorylates and inhibits upstream inhibitory kinase Ypk1p; localizes to the cytoplasm, early endosome/TGN, the plasma membrane and the shmoo tip; redundant role with KIN82 in the mating pheromone response; activity stimulated by Gin4p kinase and sphingolipid MIPC","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005330","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR047W"}


id: YNR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02516":null,"SJAG_03050":null,"YNR048W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02516","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03050","reference_uniquename":"PMID:29761456"}],"product":"Potential noncatalytic subunit for phospholipid translocase Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005331","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR048W"}


id: YNR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00280":null,"YNR049C":null},"has_protein_features":false,"name":"MSO1","ortholog_annotations":[{"gene_uniquename":"YNR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00280","reference_uniquename":"PMID:29761456"}],"product":"Lipid-interacting protein in SNARE complex assembly machinery; acts at late step in secretion; interacts with membranes through two distinct binding sites; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; N-terminus closely associates with plasma membrane, C-terminus colocalizes with Sec4p on intracellular membranes; relocalizes from bud neck to nucleus upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005332","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR049C"}


id: YNR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01061":null,"YNR050C":null},"has_protein_features":false,"name":"LYS9","ortholog_annotations":[{"gene_uniquename":"YNR050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01061","reference_uniquename":"PMID:29761456"}],"product":"Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005333","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR050C"}


id: YNR051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02663":null,"YNR051C":null},"has_protein_features":false,"name":"BRE5","ortholog_annotations":[{"gene_uniquename":"YNR051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02663","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin protease cofactor; forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the ER and Golgi compartments, deubiquitinating COPII and COPI vesicle coat constituents, Sec23p and Sec27p; involved along with Ubp3p in the steady-state retention of Golgi membrane proteins, such as glycosyltransferases; null is sensitive to brefeldin A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005334","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR051C"}


id: YNR052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04407":null,"YNR052C":null},"has_protein_features":false,"name":"POP2","ortholog_annotations":[{"gene_uniquename":"YNR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04407","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation; exonuclease of the DEDD superfamily","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005335","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR052C"}


id: YNR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01391":null,"YNR053C":null},"has_protein_features":false,"name":"NOG2","ortholog_annotations":[{"gene_uniquename":"YNR053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01391","reference_uniquename":"PMID:29761456"}],"product":"Putative GTPase; associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; recruited by ribosomal proteins L17, L35, and L37 to assembling ribosomes after 27SB pre-rRNA is generated, immediately preceding removal of ITS2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005336","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR053C"}


id: YNR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04524":null,"YNR054C":null},"has_protein_features":false,"name":"ESF2","ortholog_annotations":[{"gene_uniquename":"YNR054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04524","reference_uniquename":"PMID:29761456"}],"product":"Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005337","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR054C"}


id: YNR055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04134":null,"YNR055C":null},"has_protein_features":false,"name":"HOL1","ortholog_annotations":[{"gene_uniquename":"YNR055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04134","reference_uniquename":"PMID:29761456"}],"product":"Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005338","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR055C"}


id: YNR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BIO5","product":"Putative transmembrane protein involved in the biotin biosynthesis; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis","secondary_identifier":"SGD:S000005339","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR056C"}


id: YNR057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BIO4","product":"Dethiobiotin synthetase; catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria; expression appears to be repressed at low iron levels","secondary_identifier":"SGD:S000005340","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR057C"}


id: YNR058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00673":null,"YNR058W":null},"has_protein_features":false,"name":"BIO3","ortholog_annotations":[{"gene_uniquename":"YNR058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00673","reference_uniquename":"PMID:26896847"}],"product":"7,8-diamino-pelargonic acid aminotransferase (DAPA); catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000005341","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR058W"}


id: YNR059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MNT4","product":"Putative alpha-1,3-mannosyltransferase; not required for protein O-glycosylation; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","secondary_identifier":"SGD:S000005342","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR059W"}


id: YNR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04743":null,"YNR060W":null},"has_protein_features":false,"name":"FRE4","ortholog_annotations":[{"gene_uniquename":"YNR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Ferric reductase; reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005343","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR060W"}


id: YNR061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000005344","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR061C"}


id: YNR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PUL3","product":"Putative pulcherrimin transporter; involved in uptake of iron-transporting siderophore, pulcherrimin","secondary_identifier":"SGD:S000005345","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR062C"}


id: YNR063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PUL4","product":"Putative zinc-cluster transcription factor; involved in utilization of iron-transporting siderophore pulcherrimin","secondary_identifier":"SGD:S000005346","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR063W"}


id: YNR064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Epoxide hydrolase; member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides","secondary_identifier":"SGD:S000005347","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR064C"}


id: YNR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01488":null,"YNR065C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YNR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01488","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005348","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR065C"}


id: YNR066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative membrane-localized protein of unknown function","secondary_identifier":"SGD:S000005349","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR066C"}


id: YNR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00667":null,"SJAG_01017":null,"YNR067C":null},"has_protein_features":false,"name":"DSE4","ortholog_annotations":[{"gene_uniquename":"YNR067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00667","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01017","reference_uniquename":"PMID:29761456"}],"product":"Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005350","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR067C"}


id: YNR068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form","secondary_identifier":"SGD:S000005351","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR068C"}


id: YNR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BSC5","product":"Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro","secondary_identifier":"SGD:S000005352","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR069C"}


id: YNR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04277":null,"YNR070W":null},"has_protein_features":false,"name":"PDR18","ortholog_annotations":[{"gene_uniquename":"YNR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Transporter of the ATP-binding cassette (ABC) family; role in plasma membrane sterol incorporation; implicated in pleiotropic drug resistance; provides resistance to ethanol stress and contributes to a decreased intracellular accumulation of ethanol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005353","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR070W"}


id: YNR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative aldose 1-epimerase","secondary_identifier":"SGD:S000005354","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR071C"}


id: YNR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04905":null,"YNR072W":null},"has_protein_features":false,"name":"HXT17","ortholog_annotations":[{"gene_uniquename":"YNR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YNR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005355","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR072W"}


id: YNR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MAN2","product":"Mannitol dehydrogenase; MAN2 has a paralog, DSF1, that arose from a segmental duplication","secondary_identifier":"SGD:S000005356","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR073C"}


id: YNR074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02016":null,"YNR074C":null},"has_protein_features":false,"name":"AIF1","ortholog_annotations":[{"gene_uniquename":"YNR074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02016","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial cell death effector; translocates to the nucleus in response to apoptotic stimuli; triggers apoptosis in cells lacking HXK2; homolog of mammalian Apoptosis-Inducing Factor, putative reductase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005357","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR074C"}


id: YNR075C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028706","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR075C-A"}


id: YNR075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS10","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000005358","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR075W"}


id: YNR076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU6","product":"Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme; identical to Pau18p","secondary_identifier":"SGD:S000005359","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR076W"}


id: YNR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function, abundance changes with carbon source","secondary_identifier":"SGD:S000005360","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YNR077C"}


id: YOL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PHO80","product":"Cyclin; interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling","secondary_identifier":"SGD:S000005361","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL001W"}


id: YOL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02847":null,"YOL002C":null},"has_protein_features":false,"name":"IZH2","ortholog_annotations":[{"gene_uniquename":"YOL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02847","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane receptor for plant antifungal osmotin; involved in zinc ion homeostasis, apoptosis; negatively regulates ZRT1 and other functionally divergent genes through CCCTC promoter motif (IzRE); modulates FET3 activity in iron-independent manner; affects gene expression by influencing balance of competition between Msn2p/Msn4p and Nrg1p/Nrg2p for binding to IzRE; transcription regulated by Zap1p, zinc, fatty acid levels; homolog of mammalian adiponectin receptor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005362","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL002C"}


id: YOL003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PFA4","product":"Palmitoyltransferase with autoacylation activity; required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases","secondary_identifier":"SGD:S000005363","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL003C"}


id: YOL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00441":null,"SJAG_01804":null,"SJAG_02846":null,"YOL004W":null},"has_protein_features":false,"name":"SIN3","ortholog_annotations":[{"gene_uniquename":"YOL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00441","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01804","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02846","reference_uniquename":"PMID:29761456"}],"product":"Component of both the Rpd3S and Rpd3L histone deacetylase complexes; involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005364","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL004W"}


id: YOL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04894":null,"YOL005C":null},"has_protein_features":false,"name":"RPB11","ortholog_annotations":[{"gene_uniquename":"YOL005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04894","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005365","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL005C"}


id: YOL006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05193":null,"YOL006C":null},"has_protein_features":false,"name":"TOP1","ortholog_annotations":[{"gene_uniquename":"YOL006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05193","reference_uniquename":"PMID:29761456"}],"product":"Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005366","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL006C"}


id: YOL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSI2","product":"Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene","secondary_identifier":"SGD:S000005367","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL007C"}


id: YOL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04223":null,"YOL008W":null},"has_protein_features":false,"name":"COQ10","ortholog_annotations":[{"gene_uniquename":"YOL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04223","reference_uniquename":"PMID:29761456"}],"product":"Coenzyme Q (ubiquinone) binding protein; functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes; respiratory growth defect of the null mutant is functionally complemented by human COQ10A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005368","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL008W"}


id: YOL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03710":null,"YOL009C":null},"has_protein_features":false,"name":"MDM12","ortholog_annotations":[{"gene_uniquename":"YOL009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03710","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial outer membrane protein, ERMES complex subunit; required for transmission of mitochondria to daughter cells; required for mitophagy; may influence import and assembly of outer membrane beta-barrel proteins; localizes to mitochondria–ER contact sites; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005369","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL009C"}


id: YOL010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01476":null,"YOL010W":null},"has_protein_features":false,"name":"RCL1","ortholog_annotations":[{"gene_uniquename":"YOL010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01476","reference_uniquename":"PMID:29761456"}],"product":"Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005370","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL010W"}


id: YOL011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02091":null,"SJAG_02093":null,"SJAG_03204":null,"YOL011W":null},"has_protein_features":false,"name":"PLB3","ortholog_annotations":[{"gene_uniquename":"YOL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02091","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02093","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03204","reference_uniquename":"PMID:29761456"}],"product":"Phospholipase B (lysophospholipase) involved in lipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; PLB3 has a paralog, PLB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005371","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL011W"}


id: YOL012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03047":null,"YOL012C":null},"has_protein_features":false,"name":"HTZ1","ortholog_annotations":[{"gene_uniquename":"YOL012C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03047","reference_uniquename":"PMID:29761456"}],"product":"Histone variant H2A.Z; exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin; Htz1p-containing nucleosomes facilitate RNA Pol II passage by affecting correct assembly and modification status of RNA Pol II elongation complexes and by favoring efficient nucleosome remodeling","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005372","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL012C"}


id: YOL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05274":null,"YOL013C":null},"has_protein_features":false,"name":"HRD1","ortholog_annotations":[{"gene_uniquename":"YOL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05274","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) of misfolded proteins; upon autoubiquitination triggers retrotranslocation of misfolded proteins to cytosol for degradation; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005373","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL013C"}


id: YOL013W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by SAGE; overlaps tRNA-Pro/YNCO0011W","secondary_identifier":"SGD:S000028811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL013W-A"}


id: YOL013W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element","secondary_identifier":"SGD:S000007252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL013W-B"}


id: YOL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; mCherry fusion protein localizes to the cytosol and nucleus","secondary_identifier":"SGD:S000005374","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL014W"}


id: YOL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC10","product":"Protein of unknown function; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; null mutant displays increased levels of spontaneous Rad52p foci","secondary_identifier":"SGD:S000005375","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL015W"}


id: YOL016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02858":null,"YOL016C":null},"has_protein_features":false,"name":"CMK2","ortholog_annotations":[{"gene_uniquename":"YOL016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02858","reference_uniquename":"PMID:29761456"}],"product":"Calmodulin-dependent protein kinase; negative feedback controller of calcium/calcineurin signalling pathway, also has additional Crz1-independent role in promoting calcium tolerance; amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005376","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL016C"}


id: YOL017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ESC8","product":"Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005377","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL017W"}


id: YOL018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04978":null,"YOL018C":null},"has_protein_features":false,"name":"TLG2","ortholog_annotations":[{"gene_uniquename":"YOL018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04978","reference_uniquename":"PMID:29761456"}],"product":"Syntaxin-like t-SNARE; forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; required along with VPS45 for an early step of the constitutive CVT pathway; interactions with Vps45 prevents Tlg2p degradation, and facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL018C"}


id: YOL019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01189":null,"SJAG_04058":null,"YOL019W":null},"has_protein_features":false,"name":"TOS7","ortholog_annotations":[{"gene_uniquename":"YOL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01189","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04058","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in secretion and cell wall organization; localizes to plasma membrane microdomains called MCCs (membrane compartment occupied by Can1); GFP-fusion protein localizes to the cell periphery and vacuole; Sur7/PalI family transmembrane domain (TMD) containing protein; TOS7 has a paralog, DCV1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL019W"}


id: YOL019W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028707","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL019W-A"}


id: YOL020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YOL020W":null},"has_protein_features":false,"name":"TAT2","ortholog_annotations":[{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"High affinity tryptophan and tyrosine permease; overexpression confers FK506 and FTY720 resistance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL020W"}


id: YOL021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04006":null,"YOL021C":null},"has_protein_features":false,"name":"DIS3","ortholog_annotations":[{"gene_uniquename":"YOL021C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04006","reference_uniquename":"PMID:29761456"}],"product":"Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; similar to E. coli RNase R and to human DIS3, which partially complements dis3-81 heat sensitivity; mutations in Dis3p analogous to human mutations implicated in multiple myeloma impair exosome function; protein abundance increases under to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL021C"}


id: YOL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02911":null,"SJAG_03857":null,"YOL022C":null},"has_protein_features":false,"name":"TSR4","ortholog_annotations":[{"gene_uniquename":"YOL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02911","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03857","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic assembly chaperone for ribosomal protein Rps2p; co-translationally associates with the N-terminal extension of Rps2p to facilitate expression, solubility and ribosome assembly; released prior to the nuclear import of Rps2p; required for correct processing of 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in the S288C background but not in CEN.PK2; homologous to human PDCD2L and PDCD2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL022C"}


id: YOL023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02856":null,"YOL023W":null},"has_protein_features":false,"name":"IFM1","ortholog_annotations":[{"gene_uniquename":"YOL023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02856","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial translation initiation factor 2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005383","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL023W"}


id: YOL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL024W"}


id: YOL025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LAG2","product":"Protein that negatively regulates the SCF E3-ubiquitin ligase; regulates by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1","secondary_identifier":"SGD:S000005385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL025W"}


id: YOL026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00569":null,"YOL026C":null},"has_protein_features":false,"name":"MIM1","ortholog_annotations":[{"gene_uniquename":"YOL026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00569","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; forms a complex with Mim2p in the outer membrane that functions as cation-selective channel for translocation of positively charged precursor segments; also has a role in assembly of Tom20p into the TOM complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL026C"}


id: YOL027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01806":null,"YOL027C":null},"has_protein_features":false,"name":"MDM38","ortholog_annotations":[{"gene_uniquename":"YOL027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01806","reference_uniquename":"PMID:29761456"}],"product":"Membrane-associated mitochondrial ribosome receptor; forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; ribosome-associated protein involved in the insertion of newly synthesized proteins into the mitochondrial inner membrane; role in protein export and K+/H+ exchange; localizes to the inner mitochondrial membrane; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL027C"}


id: YOL028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YAP7","product":"Transcriptional repressor of nitric oxide oxidase; basic leucine zipper (bZIP) transcription factor; neighboring gene, YOL029C, created by frame-shift at position 708, corresponds to C-terminal part of YAP7 orthologs in other species; YAP7 has a paralog, YAP5, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL028C"}


id: YOL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; separated from neighboring gene, YAP7, by frame shift and corresponds to C-terminal part of YAP7 orthologs in other species; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens","secondary_identifier":"SGD:S000005389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL029C"}


id: YOL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00218":null,"SJAG_04483":null,"YOL030W":null},"has_protein_features":false,"name":"GAS5","ortholog_annotations":[{"gene_uniquename":"YOL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00218","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04483","reference_uniquename":"PMID:29761456"}],"product":"1,3-beta-glucanosyltransferase; has similarity to Gas1p; localizes to the cell wall","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL030W"}


id: YOL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SIL1","product":"Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; required for protein translocation into the endoplasmic reticulum (ER); homolog of Yarrowia lipolytica SLS1; GrpE-like protein","secondary_identifier":"SGD:S000005391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL031C"}


id: YOL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00586":null,"YOL032W":null},"has_protein_features":false,"name":"OPI10","ortholog_annotations":[{"gene_uniquename":"YOL032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00586","reference_uniquename":"PMID:29761456"}],"product":"Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL032W"}


id: YOL033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03071":null,"YOL033W":null},"has_protein_features":false,"name":"MSE1","ortholog_annotations":[{"gene_uniquename":"YOL033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03071","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial glutamyl-tRNA synthetase; predicted to be palmitoylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL033W"}


id: YOL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03436":null,"YOL034W":null},"has_protein_features":false,"name":"SMC5","ortholog_annotations":[{"gene_uniquename":"YOL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03436","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; supports nucleolar function; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005394","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL034W"}


id: YOL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005395","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL035C"}


id: YOL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005396","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL036W"}


id: YOL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W","secondary_identifier":"SGD:S000005397","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL037C"}


id: YOL038C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by SAGE analysis","secondary_identifier":"SGD:S000028812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL038C-A"}


id: YOL038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04306":null,"YOL038W":null},"has_protein_features":false,"name":"PRE6","ortholog_annotations":[{"gene_uniquename":"YOL038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04306","reference_uniquename":"PMID:29761456"}],"product":"Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005398","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL038W"}


id: YOL039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01128":null,"SJAG_02871":null,"YOL039W":null},"has_protein_features":false,"name":"RPP2A","ortholog_annotations":[{"gene_uniquename":"YOL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01128","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02871","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal protein P2 alpha; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005399","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL039W"}


id: YOL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02870":null,"SJAG_04256":null,"YOL040C":null},"has_protein_features":false,"name":"RPS15","ortholog_annotations":[{"gene_uniquename":"YOL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02870","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04256","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005400","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL040C"}


id: YOL041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05190":null,"YOL041C":null},"has_protein_features":false,"name":"NOP12","ortholog_annotations":[{"gene_uniquename":"YOL041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05190","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein involved in pre-25S rRNA processing; also involved in biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005401","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL041C"}


id: YOL042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NGL1","product":"Putative endonuclease; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000005402","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL042W"}


id: YOL043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03724":null,"YOL043C":null},"has_protein_features":false,"name":"NTG2","ortholog_annotations":[{"gene_uniquename":"YOL043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03724","reference_uniquename":"PMID:29761456"}],"product":"DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005403","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL043C"}


id: YOL044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PEX15","product":"Tail-anchored type II integral peroxisomal membrane protein; required for peroxisome biogenesis; cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol; overexpression results in impaired peroxisome assembly","secondary_identifier":"SGD:S000005404","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL044W"}


id: YOL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01376":null,"YOL045W":null},"has_protein_features":false,"name":"PSK2","ortholog_annotations":[{"gene_uniquename":"YOL045W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01376","reference_uniquename":"PMID:29761456"}],"product":"PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005405","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL045W"}


id: YOL046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene PSK2/YOL045W","secondary_identifier":"SGD:S000005406","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL046C"}


id: YOL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LDS2","product":"Protein Involved in spore wall assembly; localizes to lipid droplets found on or outside of the prospore membrane; shares similarity with Lds1p and Rrt8p, and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern","secondary_identifier":"SGD:S000005407","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL047C"}


id: YOL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRT8","product":"Protein involved in spore wall assembly; shares similarity with Lds1p and Lds2p and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000005408","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL048C"}


id: YOL049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01351":null,"YOL049W":null},"has_protein_features":false,"name":"GSH2","ortholog_annotations":[{"gene_uniquename":"YOL049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01351","reference_uniquename":"PMID:29761456"}],"product":"Glutathione synthetase; catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005409","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL049W"}


id: YOL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)","secondary_identifier":"SGD:S000005410","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL050C"}


id: YOL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03981":null,"YOL051W":null},"has_protein_features":false,"name":"GAL11","ortholog_annotations":[{"gene_uniquename":"YOL051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03981","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005411","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL051W"}


id: YOL052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03632":null,"YOL052C":null},"has_protein_features":false,"name":"SPE2","ortholog_annotations":[{"gene_uniquename":"YOL052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03632","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine decarboxylase; required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005412","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL052C"}


id: YOL052C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DDR2","product":"Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005413","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL052C-A"}


id: YOL053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM39","product":"Protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss; localizes to mitochondria, cytosol and to the peroxisome in a Pex5p-dependent manner in glucose","secondary_identifier":"SGD:S000005414","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL053W"}


id: YOL054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01854":null,"SJAG_03615":null,"YOL054W":null},"has_protein_features":false,"name":"PSH1","ortholog_annotations":[{"gene_uniquename":"YOL054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01854","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03615","reference_uniquename":"PMID:29761456"}],"product":"E3 ubiquitin ligase targeting centromere-binding protein Cse4p; mediates polyubiquitination and degradation of histone H3 variant Cse4p; ubiquitination of Cse4p may be antagonized by Scm3p; interacts with the FACT complex preventing mislocalization of Cse4p to euchromatin independent of Slx5p; formyl-methionine/N-recognin component of N-end rule pathway mediating destruction of formylated cytosolic proteins elevated in response to starvation or stationary phase entry","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005415","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL054W"}


id: YOL055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02420":null,"SJAG_02421":null,"SJAG_04282":null,"YOL055C":null},"has_protein_features":false,"name":"THI20","ortholog_annotations":[{"gene_uniquename":"YOL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02420","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02421","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04282","reference_uniquename":"PMID:29761456"}],"product":"Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005416","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL055C"}


id: YOL056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02009":null,"YOL056W":null},"has_protein_features":false,"name":"GPM3","ortholog_annotations":[{"gene_uniquename":"YOL056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02009","reference_uniquename":"PMID:29761456"}],"product":"Nonfunctional homolog of Gpm1p phosphoglycerate mutase; if functional, would convert 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; GPM3 has a paralog, GPM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005417","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL056W"}


id: YOL057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers","secondary_identifier":"SGD:S000005418","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL057W"}


id: YOL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04577":null,"YOL058W":null},"has_protein_features":false,"name":"ARG1","ortholog_annotations":[{"gene_uniquename":"YOL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04577","reference_uniquename":"PMID:29761456"}],"product":"Argininosuccinate synthetase; catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005419","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL058W"}


id: YOL059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00409":null,"YOL059W":null},"has_protein_features":false,"name":"GPD2","ortholog_annotations":[{"gene_uniquename":"YOL059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00409","reference_uniquename":"PMID:29761456"}],"product":"NAD-dependent glycerol 3-phosphate dehydrogenase; expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1; GPD2 has a paralog, GPD1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005420","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL059W"}


id: YOL060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04111":null,"YOL060C":null},"has_protein_features":false,"name":"MAM3","ortholog_annotations":[{"gene_uniquename":"YOL060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04111","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in magnesium homeostasis; required for Mg2+ sequestration in vacuole; required for normal mitochondrial morphology; has similarity to hemolysins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL060C"}


id: YOL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04882":null,"YOL061W":null},"has_protein_features":false,"name":"PRS5","ortholog_annotations":[{"gene_uniquename":"YOL061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04882","reference_uniquename":"PMID:29761456"}],"product":"5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL061W"}


id: YOL062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00800":null,"YOL062C":null},"has_protein_features":false,"name":"APM4","ortholog_annotations":[{"gene_uniquename":"YOL062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00800","reference_uniquename":"PMID:29761456"}],"product":"Cargo-binding mu subunit of AP-2; AP-2 is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required for AP-2 function and localization, and binds cell wall stress receptor Mid2p; AP-2 is required for cell polarity responses to pheromone, nutritional status and cell wall damage in S. cerevisiae, and for hyphal growth in C. albicans; AP-2 complex is conserved in mammals","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL062C"}


id: YOL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03507":null,"YOL063C":null},"has_protein_features":false,"name":"CRT10","ortholog_annotations":[{"gene_uniquename":"YOL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03507","reference_uniquename":"PMID:29761456"}],"product":"Protein required for the degradation of mutant 25S rRNAs; functions in Mms1 pathway of nonfunctional 25S rRNA decay; expression induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005424","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL063C"}


id: YOL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01702":null,"YOL064C":null},"has_protein_features":false,"name":"MET22","ortholog_annotations":[{"gene_uniquename":"YOL064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01702","reference_uniquename":"PMID:29761456"}],"product":"Bisphosphate-3'-nucleotidase; involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway; human homolog BPNT1 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL064C"}


id: YOL065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"INP54","product":"Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; role in secretion; localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins","secondary_identifier":"SGD:S000005426","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL065C"}


id: YOL066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01054":null,"YOL066C":null},"has_protein_features":false,"name":"RIB2","ortholog_annotations":[{"gene_uniquename":"YOL066C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01054","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional DRAP deaminase tRNA:pseudouridine synthase; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs; RIB2 has a paralog, PUS9, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005427","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL066C"}


id: YOL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RTG1","product":"Transcription factor (bHLH) involved in interorganelle communication; contributes to communication between mitochondria, peroxisomes, and nucleus; target of Hog1p; activated in stochastic pulses of nuclear localization","secondary_identifier":"SGD:S000005428","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL067C"}


id: YOL068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04186":null,"YOL068C":null},"has_protein_features":false,"name":"HST1","ortholog_annotations":[{"gene_uniquename":"YOL068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04186","reference_uniquename":"PMID:29761456"}],"product":"NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and meiotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL068C"}


id: YOL069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00794":null,"YOL069W":null},"has_protein_features":false,"name":"NUF2","ortholog_annotations":[{"gene_uniquename":"YOL069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00794","reference_uniquename":"PMID:29761456"}],"product":"Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005430","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL069W"}


id: YOL070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NBA1","product":"Protein involved in axial bud site selection; prevents repolarization of cells at previous division sites; recruited by Aim44p and Nap1p to the cell cortex and to cytokinesis remnants (bud scars) where it prevents Rsr1p-mediated activation of Cdc24p, the Cdc42p GEF; localizes to the cytoplasm, and the cell division site prior to being stably recruited to cytokinesis remnants; establishes the transient localization of Rga1p, a Cdc42p GAP, at bud scars along with Nis1p; potential Cdc28p substrate","secondary_identifier":"SGD:S000005431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL070C"}


id: YOL071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01895":null,"YOL071W":null},"has_protein_features":false,"name":"SDH5","ortholog_annotations":[{"gene_uniquename":"YOL071W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01895","reference_uniquename":"PMID:29761456"}],"product":"Protein required for flavinylation of Sdh1p; binds to Sdh1p and promotes FAD cofactor attachment, which is necessary for succinate dehydrogenase (SDH) complex assembly and activity; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005432","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL071W"}


id: YOL072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00298":null,"YOL072W":null},"has_protein_features":false,"name":"THP1","ortholog_annotations":[{"gene_uniquename":"YOL072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00298","reference_uniquename":"PMID:29761456"}],"product":"Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005433","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL072W"}


id: YOL073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03302":null,"YOL073C":null},"has_protein_features":false,"name":"DSC2","ortholog_annotations":[{"gene_uniquename":"YOL073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03302","reference_uniquename":"PMID:29761456"}],"product":"Multi-transmembrane subunit of the DSC ubiquitin ligase complex; similar in sequence to rhomboid pseudoproteases Der1p and UBAC2 that function in ERAD; ortholog of fission yeast dsc2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL073C"}


id: YOL075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative ABC transporter","secondary_identifier":"SGD:S000005435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL075C"}


id: YOL076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03045":null,"YOL076W":null},"has_protein_features":false,"name":"MDM20","ortholog_annotations":[{"gene_uniquename":"YOL076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03045","reference_uniquename":"PMID:29761456"}],"product":"Non-catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005436","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL076W"}


id: YOL077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02508":null,"YOL077C":null},"has_protein_features":false,"name":"BRX1","ortholog_annotations":[{"gene_uniquename":"YOL077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02508","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005437","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL077C"}


id: YOL077W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07003":null,"YOL077W-A":null},"has_protein_features":false,"name":"ATP19","ortholog_annotations":[{"gene_uniquename":"YOL077W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07003","reference_uniquename":"PMID:29761456"}],"product":"Subunit k of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007339","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL077W-A"}


id: YOL078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00117":null,"YOL078W":null},"has_protein_features":false,"name":"AVO1","ortholog_annotations":[{"gene_uniquename":"YOL078W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00117","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; C-terminal PH domain binds to phosphoinositide-(4,5)-bisphosphate (PI(4,5)P2); binds directly to Ypk2p a Tor2p substrate and downstream TORC2 effector through a conserved central CRIM domain; acts with Tsc11p as a scaffold important for the integrity of the TORC2 complex; dispensable for PM localization of TORC2; role in regulating actin organization and growth control; orthologous to human MAPKAP1/SIN1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL078W"}


id: YOL079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL079W"}


id: YOL080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00841":null,"YOL080C":null},"has_protein_features":false,"name":"REX4","ortholog_annotations":[{"gene_uniquename":"YOL080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00841","reference_uniquename":"PMID:29761456"}],"product":"Putative RNA exonuclease; possibly involved in pre-rRNA processing and ribosome assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005440","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL080C"}


id: YOL081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRA2","product":"GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; IRA2 has a paralog, IRA1, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis","secondary_identifier":"SGD:S000005441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL081W"}


id: YOL082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03976":null,"YOL082W":null},"has_protein_features":false,"name":"ATG19","ortholog_annotations":[{"gene_uniquename":"YOL082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03976","reference_uniquename":"PMID:29761456"}],"product":"Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles; interaction with Atg19p during the Cvt pathway requires phosphorylation by Hrr25p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005442","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL082W"}


id: YOL083C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028853","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL083C-A"}


id: YOL083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG34","product":"Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog","secondary_identifier":"SGD:S000005443","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL083W"}


id: YOL084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PHM7","product":"Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000005444","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL084W"}


id: YOL085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YOL085C is not an essential gene; partially overlaps dubious ORF YOL085W-A","secondary_identifier":"SGD:S000005445","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL085C"}


id: YOL085W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C","secondary_identifier":"SGD:S000028708","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL085W-A"}


id: YOL086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01414":null,"SJAG_03370":null,"YOL086C":null},"has_protein_features":false,"name":"ADH1","ortholog_annotations":[{"gene_uniquename":"YOL086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01414","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03370","reference_uniquename":"PMID:29761456"}],"product":"Alcohol dehydrogenase; fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway; ADH1 has a paralog, ADH5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005446","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL086C"}


id: YOL086W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00935":null,"YOL086W-A":null},"has_protein_features":false,"name":"MHF1","ortholog_annotations":[{"gene_uniquename":"YOL086W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00935","reference_uniquename":"PMID:29761456"}],"product":"Component of the heterotetrameric MHF histone-fold complex; in humans the MHF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL086W-A"}


id: YOL087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00805":null,"YOL087C":null},"has_protein_features":false,"name":"DUF1","ortholog_annotations":[{"gene_uniquename":"YOL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00805","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005447","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL087C"}


id: YOL088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03414":null,"YOL088C":null},"has_protein_features":false,"name":"MPD2","ortholog_annotations":[{"gene_uniquename":"YOL088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03414","reference_uniquename":"PMID:29761456"}],"product":"Member of the protein disulfide isomerase (PDI) family; exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005448","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL088C"}


id: YOL089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HAL9","product":"Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005449","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL089C"}


id: YOL090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02226":null,"YOL090W":null},"has_protein_features":false,"name":"MSH2","ortholog_annotations":[{"gene_uniquename":"YOL090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02226","reference_uniquename":"PMID:29761456"}],"product":"Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP; required for silencing at the silent mating-type loci and telomeres","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005450","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL090W"}


id: YOL091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPO21","product":"Component of the meiotic outer plaque of the spindle pole body; involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation; SPO21 has a paralog, YSW1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005451","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL091W"}


id: YOL092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00051":null,"SJAG_04787":null,"YOL092W":null},"has_protein_features":false,"name":"YPQ1","ortholog_annotations":[{"gene_uniquename":"YOL092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00051","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04787","reference_uniquename":"PMID:29761456"}],"product":"Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; YPQ1 has a paralog, RTC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005452","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL092W"}


id: YOL093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04993":null,"YOL093W":null},"has_protein_features":false,"name":"TRM10","ortholog_annotations":[{"gene_uniquename":"YOL093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04993","reference_uniquename":"PMID:29761456"}],"product":"tRNA methyltransferase; methylates the N-1 of guanine at position 9 in tRNAs; involved in the methylation of guanosine and uridine ribonucleosides in mRNA; member of the SPOUT (SpoU-TrmD) methyltransferase family; human ortholog TRMT10A plays a role in the pathogenesis of microcephaly and early onset diabetes; an 18-mer ncRNA originates from the TRM10 locus; genetic analysis shows the 18-mer ncRNA is a translational regulator; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005453","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL093W"}


id: YOL094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00729":null,"YOL094C":null},"has_protein_features":false,"name":"RFC4","ortholog_annotations":[{"gene_uniquename":"YOL094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00729","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005454","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL094C"}


id: YOL095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HMI1","product":"Mitochondrial inner membrane localized ATP-dependent DNA helicase; required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD","secondary_identifier":"SGD:S000005455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL095C"}


id: YOL096C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01911":null,"SJAG_04642":null,"YOL096C":null},"has_protein_features":false,"name":"COQ3","ortholog_annotations":[{"gene_uniquename":"YOL096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01911","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL096C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04642","reference_uniquename":"PMID:29761456"}],"product":"O-methyltransferase; catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005456","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL096C"}


id: YOL097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01522":null,"YOL097C":null},"has_protein_features":false,"name":"WRS1","ortholog_annotations":[{"gene_uniquename":"YOL097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01522","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic tryptophanyl-tRNA synthetase; aminoacylates tryptophanyl-tRNA; human homolog WARS can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005457","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL097C"}


id: YOL097W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028854","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL097W-A"}


id: YOL098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03393":null,"YOL098C":null},"has_protein_features":false,"name":"SDD3","ortholog_annotations":[{"gene_uniquename":"YOL098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03393","reference_uniquename":"PMID:29761456"}],"product":"Putative metalloprotease; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005458","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL098C"}


id: YOL099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes","secondary_identifier":"SGD:S000005459","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL099C"}


id: YOL100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02468":null,"SJAG_05290":null,"YOL100W":null},"has_protein_features":false,"name":"PKH2","ortholog_annotations":[{"gene_uniquename":"YOL100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02468","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05290","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; contains a PH-like domain; redundant with Pkh1p; PKH2 has a paralog, PKH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005460","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL100W"}


id: YOL101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IZH4","product":"Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress; IZH4 has a paralog, IZH1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005461","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL101C"}


id: YOL102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03913":null,"YOL102C":null},"has_protein_features":false,"name":"TPT1","ortholog_annotations":[{"gene_uniquename":"YOL102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03913","reference_uniquename":"PMID:29761456"}],"product":"tRNA 2'-phosphotransferase; catalyzes the final step in tRNA splicing, transferring the 2'-PO(4) from the splice junction to NAD(+), forming ADP-ribose 1''-2''cyclic phosphate and nicotinamide; ADP-ribosyltransferase that ADP-ribosylates 5'-phosphorylated ssDNA and ssRNAs; human and mouse orthologs complement the inviability of the yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005462","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL102C"}


id: YOL103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03595":null,"SJAG_04506":null,"YOL103W":null},"has_protein_features":false,"name":"ITR2","ortholog_annotations":[{"gene_uniquename":"YOL103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03595","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04506","reference_uniquename":"PMID:29761456"}],"product":"Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog, ITR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005463","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL103W"}


id: YOL104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NDJ1","product":"Protein that regulates meiotic SPB cohesion and telomere clustering; localizes to both spindle pole bodies (SPBs) and telomeres; required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement","secondary_identifier":"SGD:S000005464","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL104C"}


id: YOL105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02258":null,"YOL105C":null},"has_protein_features":false,"name":"WSC3","ortholog_annotations":[{"gene_uniquename":"YOL105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02258","reference_uniquename":"PMID:29761456"}],"product":"Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity; involved in response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis; WSC3 has a paralog, WSC2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005465","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL105C"}


id: YOL106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005466","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL106W"}


id: YOL107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01927":null,"YOL107W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOL107W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01927","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005467","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL107W"}


id: YOL108C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"INO4","product":"Transcription factor involved in phospholipid synthesis; required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain","secondary_identifier":"SGD:S000005468","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL108C"}


id: YOL109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ZEO1","product":"Peripheral membrane protein of the plasma membrane; interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria","secondary_identifier":"SGD:S000005469","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL109W"}


id: YOL110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01349":null,"YOL110W":null},"has_protein_features":false,"name":"SHR5","ortholog_annotations":[{"gene_uniquename":"YOL110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01349","reference_uniquename":"PMID:29761456"}],"product":"Palmitoyltransferase subunit; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization; Palmitoyltransferase is composed of Shr5p and Erf2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005470","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL110W"}


id: YOL111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MDY2","product":"Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes","secondary_identifier":"SGD:S000005471","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL111C"}


id: YOL112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01048":null,"YOL112W":null},"has_protein_features":false,"name":"MSB4","ortholog_annotations":[{"gene_uniquename":"YOL112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01048","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein of the Ras superfamily; acts primarily on Sec4p, localizes to the bud site and bud tip; msb3 msb4 double mutation causes defects in secretion and actin organization; similar to the TBC-domain Tre2 oncogene; MSB4 has a paralog, MSB3, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL112W"}


id: YOL113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02878":null,"YOL113W":null},"has_protein_features":false,"name":"SKM1","ortholog_annotations":[{"gene_uniquename":"YOL113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02878","reference_uniquename":"PMID:29761456"}],"product":"Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005473","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL113W"}


id: YOL114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05221":null,"YOL114C":null},"has_protein_features":false,"name":"PTH4","ortholog_annotations":[{"gene_uniquename":"YOL114C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05221","reference_uniquename":"PMID:29761456"}],"product":"Stalled-ribosome rescue factor srRF1; similar to human peptidyl-tRNA hydrolase ICT1; associates with mitochondrial large subunit; not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005474","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL114C"}


id: YOL115W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01176":null,"YOL115W":null},"has_protein_features":false,"name":"PAP2","ortholog_annotations":[{"gene_uniquename":"YOL115W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01176","reference_uniquename":"PMID:29761456"}],"product":"Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of TRAMP; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; required for mRNA surveillance and maintenance of genome integrity, serving as a link between RNA and DNA metabolism; overlapping but non-redundant functions with Trf5p; relocalizes to cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005475","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL115W"}


id: YOL116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MSN1","product":"Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000005476","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL116W"}


id: YOL117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRI2","product":"Subunit of the COP9 signalosome (CSN) complex; this complex cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response","secondary_identifier":"SGD:S000005477","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL117W"}


id: YOL118C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000005478","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL118C"}


id: YOL119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MCH4","product":"Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport","secondary_identifier":"SGD:S000005479","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL119C"}


id: YOL120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02597":null,"SJAG_03335":null,"YOL120C":null},"has_protein_features":false,"name":"RPL18A","ortholog_annotations":[{"gene_uniquename":"YOL120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02597","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03335","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005480","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL120C"}


id: YOL121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01296":null,"SJAG_02335":null,"YOL121C":null},"has_protein_features":false,"name":"RPS19A","ortholog_annotations":[{"gene_uniquename":"YOL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02335","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005481","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL121C"}


id: YOL122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01007":null,"YOL122C":null},"has_protein_features":false,"name":"SMF1","ortholog_annotations":[{"gene_uniquename":"YOL122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01007","reference_uniquename":"PMID:29761456"}],"product":"Divalent metal ion transporter; broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005482","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL122C"}


id: YOL123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03853":null,"YOL123W":null},"has_protein_features":false,"name":"HRP1","ortholog_annotations":[{"gene_uniquename":"YOL123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03853","reference_uniquename":"PMID:29761456"}],"product":"Subunit of cleavage factor I; cleavage factor I is a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences; required for genome stability; plays a role in copper homeostasis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005483","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL123W"}


id: YOL124C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04181":null,"YOL124C":null},"has_protein_features":false,"name":"TRM11","ortholog_annotations":[{"gene_uniquename":"YOL124C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04181","reference_uniquename":"PMID:29761456"}],"product":"Catalytic subunit of adoMet-dependent tRNA methyltransferase complex; required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; involved in the methylation of guanosine and uridine ribonucleosides in mRNA; contains a THUMP domain and a methyltransferase domain; methyltransferase complex also contains Trm112p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005484","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL124C"}


id: YOL125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01375":null,"YOL125W":null},"has_protein_features":false,"name":"TRM13","ortholog_annotations":[{"gene_uniquename":"YOL125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01375","reference_uniquename":"PMID:29761456"}],"product":"2'-O-methyltransferase; responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005485","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL125W"}


id: YOL126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MDH2","product":"Cytoplasmic malate dehydrogenase; one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1; mutation in human homolog MDH2 causes early-onset severe encephalopathy","secondary_identifier":"SGD:S000005486","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL126C"}


id: YOL127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02840":null,"SJAG_04304":null,"YOL127W":null},"has_protein_features":false,"name":"RPL25","ortholog_annotations":[{"gene_uniquename":"YOL127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02840","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04304","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005487","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL127W"}


id: YOL128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YGK3","product":"Protein kinase related to mammalian GSK-3 glycogen synthase kinases; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation; YGK3 has a paralog, MCK1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005488","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL128C"}


id: YOL129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03511":null,"YOL129W":null},"has_protein_features":false,"name":"VPS68","ortholog_annotations":[{"gene_uniquename":"YOL129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03511","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane protein of unknown function; involved in vacuolar protein sorting; also detected in the mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005489","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL129W"}


id: YOL130W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03516":null,"YOL130W":null},"has_protein_features":false,"name":"ALR1","ortholog_annotations":[{"gene_uniquename":"YOL130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03516","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane Mg(2+) transporter; expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; magnesium transport defect of the null mutant is functionally complemented by either of the human genes MAGT1 and TUSC3 that are not orthologous to ALR1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005490","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL130W"}


id: YOL131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YOL131W has a paralog, STB1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005491","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL131W"}


id: YOL132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01835":null,"YOL132W":null},"has_protein_features":false,"name":"GAS4","ortholog_annotations":[{"gene_uniquename":"YOL132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01835","reference_uniquename":"PMID:26896847"}],"product":"1,3-beta-glucanosyltransferase; involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000005492","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL132W"}


id: YOL133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00341":null,"YOL133W":null},"has_protein_features":false,"name":"HRT1","ortholog_annotations":[{"gene_uniquename":"YOL133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00341","reference_uniquename":"PMID:29761456"}],"product":"RING-H2 domain core subunit of multiple ubiquitin ligase complexes; subunit of Skp1-Cullin-F-box (SCF) that tethers the Cdc34p (E2) and Cdc53p (cullin) SCF subunits, and is required for degradation of Gic2p, Far1p, Sic1p and Cln2p; subunit of the Rtt101p-Mms1p-Mms22p ubiquitin ligase that stabilizes replication forks after DNA lesions; subunit of the Cul3p-Elc1p-Ela1p ubiquitin ligase involved in Rpb1p degradation as part of transcription-coupled repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005493","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL133W"}


id: YOL134C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit","secondary_identifier":"SGD:S000005494","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL134C"}


id: YOL135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02849":null,"YOL135C":null},"has_protein_features":false,"name":"MED7","ortholog_annotations":[{"gene_uniquename":"YOL135C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02849","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005495","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL135C"}


id: YOL136C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PFK27","product":"6-phosphofructo-2-kinase; catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A","secondary_identifier":"SGD:S000005496","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL136C"}


id: YOL137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BSC6","product":"Protein of unknown function with 8 putative transmembrane segments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression","secondary_identifier":"SGD:S000005497","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL137W"}


id: YOL138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04496":null,"YOL138C":null},"has_protein_features":false,"name":"RTC1","ortholog_annotations":[{"gene_uniquename":"YOL138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04496","reference_uniquename":"PMID:29761456"}],"product":"Subunit of SEACAT, a subcomplex of the SEA complex; Rtc1p, along with Mtc5p and Sea4p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; null suppresses cdc13-1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005498","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL138C"}


id: YOL139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00507":null,"SJAG_03223":null,"YOL139C":null},"has_protein_features":false,"name":"CDC33","ortholog_annotations":[{"gene_uniquename":"YOL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00507","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03223","reference_uniquename":"PMID:29761456"}],"product":"Translation initiation factor eIF4E; mRNA cap binding protein and subunit of the mRNA cap-binding complex (eIF4F) along with eIF4A (Tif1p/Tif2p) and eIF4G (Tif4631p/Tif4632p), that mediates cap-dependent translation; required with eIF4G for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; protein abundance increases in response to DNA replication stress; human homolog EIF4E can complement the cdc33 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005499","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL139C"}


id: YOL140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01019":null,"YOL140W":null},"has_protein_features":false,"name":"ARG8","ortholog_annotations":[{"gene_uniquename":"YOL140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01019","reference_uniquename":"PMID:29761456"}],"product":"Acetylornithine aminotransferase; catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005500","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL140W"}


id: YOL141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01261":null,"YOL141W":null},"has_protein_features":false,"name":"PPM2","ortholog_annotations":[{"gene_uniquename":"YOL141W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01261","reference_uniquename":"PMID:29761456"}],"product":"AdoMet-dependent tRNA methyltransferase; also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005501","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL141W"}


id: YOL142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04321":null,"YOL142W":null},"has_protein_features":false,"name":"RRP40","ortholog_annotations":[{"gene_uniquename":"YOL142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04321","reference_uniquename":"PMID:29761456"}],"product":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; mutations in the human homolog, EXOSC3, cause pontocerebellar hypoplasia with motor neuron degeneration","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005502","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL142W"}


id: YOL143C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02360":null,"YOL143C":null},"has_protein_features":false,"name":"RIB4","ortholog_annotations":[{"gene_uniquename":"YOL143C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02360","reference_uniquename":"PMID:29761456"}],"product":"Lumazine synthase (DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6,7-dimethyl-8-ribityllumazine synthase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005503","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL143C"}


id: YOL144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04610":null,"YOL144W":null},"has_protein_features":false,"name":"NOP8","ortholog_annotations":[{"gene_uniquename":"YOL144W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04610","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein required for 60S ribosomal subunit biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005504","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL144W"}


id: YOL145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00139":null,"YOL145C":null},"has_protein_features":false,"name":"CTR9","ortholog_annotations":[{"gene_uniquename":"YOL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00139","reference_uniquename":"PMID:29761456"}],"product":"Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005505","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL145C"}


id: YOL146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00536":null,"YOL146W":null},"has_protein_features":false,"name":"PSF3","ortholog_annotations":[{"gene_uniquename":"YOL146W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00536","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005506","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL146W"}


id: YOL147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02788":null,"SJAG_04146":null,"YOL147C":null},"has_protein_features":false,"name":"PEX11","ortholog_annotations":[{"gene_uniquename":"YOL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02788","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04146","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal protein required for medium-chain fatty acid oxidation; also required for peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005507","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL147C"}


id: YOL148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01658":null,"YOL148C":null},"has_protein_features":false,"name":"SPT20","ortholog_annotations":[{"gene_uniquename":"YOL148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01658","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SAGA transcriptional regulatory complex; involved in maintaining the integrity of the complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005508","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL148C"}


id: YOL149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05694":null,"YOL149W":null},"has_protein_features":false,"name":"DCP1","ortholog_annotations":[{"gene_uniquename":"YOL149W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05694","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005509","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL149W"}


id: YOL150C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005510","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL150C"}


id: YOL151W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02960":null,"YOL151W":null},"has_protein_features":false,"name":"GRE2","ortholog_annotations":[{"gene_uniquename":"YOL151W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02960","reference_uniquename":"PMID:29761456"}],"product":"3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005511","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL151W"}


id: YOL152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04743":null,"YOL152W":null},"has_protein_features":false,"name":"FRE7","ortholog_annotations":[{"gene_uniquename":"YOL152W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005512","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL152W"}


id: YOL153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Blocked reading frame, contains two in-frame stops in translation; this ORF is conserved, without the stops, in Saccharomyces paradoxus, S. mikatae, and S. bayanus; RNA sequencing data indicate the presence of a transcription unit at this reading frame","secondary_identifier":"SGD:S000005513","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL153C"}


id: YOL154W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ZPS1","product":"Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH","secondary_identifier":"SGD:S000005514","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL154W"}


id: YOL155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HPF1","product":"Haze-protective mannoprotein; reduces particle size of aggregated proteins in white wines, thereby decreasing turbidity; intragenic repeat expansion controls chronological aging; expansion of intragenic tandem repeats within N-terminus sufficient to cause pronounced life span shortening; repeat expansion shifts cells from sedentary to buoyant, thereby increasing exposure to oxygen, altering methionine, lipid, and purine metabolism","secondary_identifier":"SGD:S000005515","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL155C"}


id: YOL155W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028855","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL155W-A"}


id: YOL156W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YOL156W":null},"has_protein_features":false,"name":"HXT11","ortholog_annotations":[{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Hexose transporter; capable of transporting a broad range of substrates including: glucose, fructose, mannose and galactose; polyol transporter that supports the growth on and uptake of xylitol with low affinity when overexpressed in a strain deleted for hexose family members; nearly identical in sequence to Hxt9p; has similarity to major facilitator superfamily (MFS) transporters; involved in pleiotropic drug resistance","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005516","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL156W"}


id: YOL157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IMA2","product":"Isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; not required for isomaltose utilization, but Ima2p overexpression allows the ima1 null mutant to grow on isomaltose","secondary_identifier":"SGD:S000005517","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL157C"}


id: YOL158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YOL158C":null},"has_protein_features":false,"name":"ENB1","ortholog_annotations":[{"gene_uniquename":"YOL158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOL158C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"Ferric enterobactin transmembrane transporter; expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005518","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL158C"}


id: YOL159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSS3","product":"Protein of unknown function, secreted when constitutively expressed; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cell periphery, SWAT-GFP fusion also localizes to the extracellular region, and mCherry fusion also localizes to the vacuole; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA","secondary_identifier":"SGD:S000005519","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL159C"}


id: YOL159C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species","secondary_identifier":"SGD:S000007627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL159C-A"}


id: YOL160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000005520","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL160W"}


id: YOL161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU20","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; expression induced by low temperature and also by anaerobic conditions; induced during alcoholic fermentation","secondary_identifier":"SGD:S000005521","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL161C"}


id: YOL162W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; proposed to be an inactive evolutionary remnant that along with neighboring gene YOL163W may have constituted a second sulfonate transporter and SOA1 paralog that is intact in S. uvarum, S. eubayanus and S. arboricola and named SOA2; member of the Dal5p subfamily of the major facilitator family","secondary_identifier":"SGD:S000005522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL162W"}


id: YOL163W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; proposed to be an inactive evolutionary remnant that along with neighboring gene YOL162W may have constituted a second sulfonate transporter and SOA1 paralog that is intact in S. uvarum, S. eubayanus and S. arboricola and named SOA2; member of the Dal5p subfamily of the major facilitator family","secondary_identifier":"SGD:S000005523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL163W"}


id: YOL164W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BDS1","product":"Bacterially-derived sulfatase; required for use of alkyl sulfates as sulfur source","secondary_identifier":"SGD:S000005524","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL164W"}


id: YOL164W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028580","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL164W-A"}


id: YOL165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AAD15","product":"Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD15 has a paralog, AAD3, that arose from a segmental duplication; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family","secondary_identifier":"SGD:S000005525","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL165C"}


id: YOL166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL166C"}


id: YOL166W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028709","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOL166W-A"}


id: YOR001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03745":null,"YOR001W":null},"has_protein_features":false,"name":"RRP6","ortholog_annotations":[{"gene_uniquename":"YOR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03745","reference_uniquename":"PMID:29761456"}],"product":"Nuclear exosome exonuclease component; has 3'-5' exonuclease activity that is regulated by Lrp1p; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; role in sn/snoRNAs precursor degradation; forms a stable heterodimer with Lrp1p; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005527","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR001W"}


id: YOR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03656":null,"YOR002W":null},"has_protein_features":false,"name":"ALG6","ortholog_annotations":[{"gene_uniquename":"YOR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03656","reference_uniquename":"PMID:29761456"}],"product":"ER-luminal alpha 1,3 glucosyltransferase; involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; C998T transition in human ortholog ALG6 causes carbohydrate-deficient glycoprotein syndrome type-Ic; wild-type human ortholog ALG6 can partially complement yeast alg6 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005528","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR002W"}


id: YOR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02432":null,"SJAG_04785":null,"YOR003W":null},"has_protein_features":false,"name":"YSP3","ortholog_annotations":[{"gene_uniquename":"YOR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02432","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04785","reference_uniquename":"PMID:29761456"}],"product":"Putative precursor of the subtilisin-like protease III; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YSP3 has a paralog, PRB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005529","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR003W"}


id: YOR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00253":null,"YOR004W":null},"has_protein_features":false,"name":"UTP23","ortholog_annotations":[{"gene_uniquename":"YOR004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00253","reference_uniquename":"PMID:29761456"}],"product":"Component of the small subunit processome; involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005530","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR004W"}


id: YOR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02527":null,"YOR005C":null},"has_protein_features":false,"name":"DNL4","ortholog_annotations":[{"gene_uniquename":"YOR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02527","reference_uniquename":"PMID:29761456"}],"product":"DNA ligase required for nonhomologous end-joining (NHEJ); forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth; mutations in human ortholog lead to ligase IV syndrome and Dubowitz syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005531","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR005C"}


id: YOR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03755":null,"YOR006C":null},"has_protein_features":false,"name":"TSR3","ortholog_annotations":[{"gene_uniquename":"YOR006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03755","reference_uniquename":"PMID:29761456"}],"product":"Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress; also detected in peroxisomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005532","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR006C"}


id: YOR007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01496":null,"YOR007C":null},"has_protein_features":false,"name":"SGT2","ortholog_annotations":[{"gene_uniquename":"YOR007C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01496","reference_uniquename":"PMID:29761456"}],"product":"Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; similar to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005533","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR007C"}


id: YOR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02258":null,"YOR008C":null},"has_protein_features":false,"name":"SLG1","ortholog_annotations":[{"gene_uniquename":"YOR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02258","reference_uniquename":"PMID:29761456"}],"product":"Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005534","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR008C"}


id: YOR008C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; includes a potential transmembrane domain; deletion results in slightly lengthened telomeres; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","secondary_identifier":"SGD:S000006431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR008C-A"}


id: YOR008W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR008W-B"}


id: YOR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TIR4","product":"Cell wall mannoprotein; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins","secondary_identifier":"SGD:S000005535","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR009W"}


id: YOR010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TIR2","product":"Putative cell wall mannoprotein; member of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis; TIR2 has a paralog, TIR3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005536","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR010C"}


id: YOR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04277":null,"YOR011W":null},"has_protein_features":false,"name":"AUS1","ortholog_annotations":[{"gene_uniquename":"YOR011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen; AUS1 has a paralog, PDR11, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005537","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR011W"}


id: YOR011W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028581","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR011W-A"}


id: YOR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01619":null,"YOR012W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01619","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005538","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR012W"}


id: YOR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC11","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012W; null mutant displays increased levels of spontaneous Rad52 foci","secondary_identifier":"SGD:S000005539","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR013W"}


id: YOR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03353":null,"SJAG_03681":null,"YOR014W":null},"has_protein_features":false,"name":"RTS1","ortholog_annotations":[{"gene_uniquename":"YOR014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03353","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03681","reference_uniquename":"PMID:29761456"}],"product":"B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005540","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR014W"}


id: YOR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YOR015W is not an essential gene","secondary_identifier":"SGD:S000005541","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR015W"}


id: YOR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03270":null,"YOR016C":null},"has_protein_features":false,"name":"ERP4","ortholog_annotations":[{"gene_uniquename":"YOR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03270","reference_uniquename":"PMID:29761456"}],"product":"Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; ERP4 has a paralog, ERP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005542","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR016C"}


id: YOR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02526":null,"YOR017W":null},"has_protein_features":false,"name":"PET127","ortholog_annotations":[{"gene_uniquename":"YOR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02526","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005543","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR017W"}


id: YOR018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00803":null,"SJAG_01686":null,"YOR018W":null},"has_protein_features":false,"name":"ROD1","ortholog_annotations":[{"gene_uniquename":"YOR018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00803","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR018W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01686","reference_uniquename":"PMID:29761456"}],"product":"Alpha-arrestin involved in ubiquitin-dependent endocytosis; activating dephosphorylation relays glucose signaling to transporter endocytosis; calcineurin dephosphorylation is required for Rsp5p-dependent internalization of agonist-occupied Ste2p, as part of signal desensitization; recruits Rsp5p to Ste2p via its 2 PPXY motifs; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005544","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR018W"}


id: YOR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; YOR019W has a paralog, JIP4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005545","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR019W"}


id: YOR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01684":null,"YOR020C":null},"has_protein_features":false,"name":"HSP10","ortholog_annotations":[{"gene_uniquename":"YOR020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01684","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial matrix co-chaperonin; inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005546","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR020C"}


id: YOR020W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MCO10","product":"Subunit l of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; more abundant in the ATP synthase monomer; involved in the calcium-induced permeability transition and calcium homeostasis; does not impact ATP synthase activity and stability; N-terminal region has sequence similarity to Atp19p; conserved in A. gossypii; detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000028526","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR020W-A"}


id: YOR021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SFM1","product":"SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism","secondary_identifier":"SGD:S000005547","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR021C"}


id: YOR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00199":null,"SJAG_04292":null,"YOR022C":null},"has_protein_features":false,"name":"DDL1","ortholog_annotations":[{"gene_uniquename":"YOR022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00199","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04292","reference_uniquename":"PMID:29761456"}],"product":"DDHD domain-containing phospholipase A1; mitochondrial matrix enzyme with sn-1-specific activity, hydrolyzing cardiolipin, PE, PC, PG and PA; implicated in remodeling of mitochondrial phospholipids; antagonistically regulated by Aft1p and Aft2p; in humans, mutations in DDHD1 and DDHD2 genes cause specific types of hereditary spastic paraplegia, while DDL1-defective yeast share similar phenotypes such as mitochondrial dysfunction and defects in lipid metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005548","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR022C"}


id: YOR023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AHC1","product":"Subunit of the Ada histone acetyltransferase complex; required for structural integrity of the complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; Ahc2p may tether Ahc1p to the complex","secondary_identifier":"SGD:S000005549","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR023C"}


id: YOR024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005550","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR024W"}


id: YOR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04039":null,"YOR025W":null},"has_protein_features":false,"name":"HST3","ortholog_annotations":[{"gene_uniquename":"YOR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04039","reference_uniquename":"PMID:29761456"}],"product":"Sirtuin, histone H3 deacetylase; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; member of the Sir2 family of NAD(+)-dependent protein deacetylases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005551","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR025W"}


id: YOR026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02451":null,"YOR026W":null},"has_protein_features":false,"name":"BUB3","ortholog_annotations":[{"gene_uniquename":"YOR026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02451","reference_uniquename":"PMID:29761456"}],"product":"Kinetochore checkpoint WD40 repeat protein; localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p; functions at kinetochore to activate APC/C-Cdc20p for normal mitotic progression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005552","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR026W"}


id: YOR027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03717":null,"YOR027W":null},"has_protein_features":false,"name":"STI1","ortholog_annotations":[{"gene_uniquename":"YOR027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03717","reference_uniquename":"PMID:29761456"}],"product":"Evolutionarily-conserved Hsp90 cochaperone; regulates spatial organization of amyloid-like proteins in the cytosol, thereby buffering the proteotoxicity caused by amyloid-like proteins; interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005553","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR027W"}


id: YOR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CIN5","product":"Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005554","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR028C"}


id: YOR029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YOR029W is not an essential gene","secondary_identifier":"SGD:S000005555","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR029W"}


id: YOR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DFG16","product":"Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p","secondary_identifier":"SGD:S000005556","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR030W"}


id: YOR031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CRS5","product":"Copper-binding metallothionein; required for wild-type copper resistance","secondary_identifier":"SGD:S000005557","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR031W"}


id: YOR032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HMS1","product":"bHLH protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant","secondary_identifier":"SGD:S000005558","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR032C"}


id: YOR032W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028710","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR032W-A"}


id: YOR033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01832":null,"YOR033C":null},"has_protein_features":false,"name":"EXO1","ortholog_annotations":[{"gene_uniquename":"YOR033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01832","reference_uniquename":"PMID:29761456"}],"product":"5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair, MMS2 error-free branch of the post replication (PRR) pathway and DNA mismatch repair; role in telomere maintenance; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress; EXO1 has a paralog, DIN7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005559","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR033C"}


id: YOR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01112":null,"YOR034C":null},"has_protein_features":false,"name":"AKR2","ortholog_annotations":[{"gene_uniquename":"YOR034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01112","reference_uniquename":"PMID:29761456"}],"product":"Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005560","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR034C"}


id: YOR034C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028856","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR034C-A"}


id: YOR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00750":null,"YOR035C":null},"has_protein_features":false,"name":"SHE4","ortholog_annotations":[{"gene_uniquename":"YOR035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00750","reference_uniquename":"PMID:29761456"}],"product":"Protein containing a UCS (UNC-45/CRO1/SHE4) domain; binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005561","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR035C"}


id: YOR036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03848":null,"YOR036W":null},"has_protein_features":false,"name":"PEP12","ortholog_annotations":[{"gene_uniquename":"YOR036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03848","reference_uniquename":"PMID:29761456"}],"product":"Target membrane receptor (t-SNARE); for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005562","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR036W"}


id: YOR037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03456":null,"YOR037W":null},"has_protein_features":false,"name":"CYC2","ortholog_annotations":[{"gene_uniquename":"YOR037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03456","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial peripheral inner membrane protein; contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005563","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR037W"}


id: YOR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00913":null,"SJAG_00925":null,"YOR038C":null},"has_protein_features":false,"name":"HIR2","ortholog_annotations":[{"gene_uniquename":"YOR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00913","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00925","reference_uniquename":"PMID:29761456"}],"product":"Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005564","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR038C"}


id: YOR039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00142":null,"SJAG_03931":null,"YOR039W":null},"has_protein_features":false,"name":"CKB2","ortholog_annotations":[{"gene_uniquename":"YOR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00142","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03931","reference_uniquename":"PMID:29761456"}],"product":"Beta' regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005565","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR039W"}


id: YOR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01596":null,"YOR040W":null},"has_protein_features":false,"name":"GLO4","ortholog_annotations":[{"gene_uniquename":"YOR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01596","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO4 has a paralog, GLO2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR040W"}


id: YOR041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance","secondary_identifier":"SGD:S000005567","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR041C"}


id: YOR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05335":null,"YOR042W":null},"has_protein_features":false,"name":"CUE5","ortholog_annotations":[{"gene_uniquename":"YOR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05335","reference_uniquename":"PMID:29761456"}],"product":"Selective autophagy receptor involved in aggrephagy and proteaphagy; ubiquitin (Ub)-binding protein that functions as a Ub-Atg8p adaptor in Ub-dependent autophagy; serves as a proteaphagy receptor for inactivate 26S proteasomes; contains a CUE domain that binds K48-and K63-linked Ub chains and monoubiquitin, facilitating intramolecular monoubiquitination; human TOLLIP is a functional CUE-domain homolog, that complements a null mutant, rescuing the hypersensitivity of the null mutant to Htt-96Q","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005568","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR042W"}


id: YOR043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01629":null,"SJAG_02687":null,"YOR043W":null},"has_protein_features":false,"name":"WHI2","ortholog_annotations":[{"gene_uniquename":"YOR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01629","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR043W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02687","reference_uniquename":"PMID:29761456"}],"product":"Negative regulator of TORC1 in response to limiting leucine; suppresses TORC1 activity with binding partners Psr1p/Psr2p, acting in parallel with SEACIT; regulates cell cycle arrest in stationary phase; inhibits Ras-cAMP-PKA regulation of apoptosis during nutrient depletion; required with Psr1p for activation of the general stress response; role in rapamycin-induced mitophagy; localizes to the cell periphery; human tumor suppressor and Whi2-like protein KCTD11 functionally complements the null","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005569","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR043W"}


id: YOR044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC23","product":"Protein of unknown function involved in multidrug resistance; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005570","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR044W"}


id: YOR045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TOM6","product":"Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex","secondary_identifier":"SGD:S000005571","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR045W"}


id: YOR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04480":null,"YOR046C":null},"has_protein_features":false,"name":"DBP5","ortholog_annotations":[{"gene_uniquename":"YOR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04480","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus, remodeling messenger ribonucleoprotein particles (mRNPs), with ATPase activity stimulated by Gle1p, IP6 and Nup159p; involved in translation termination along with Sup45p (eRF1); role in the cellular response to heat stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005572","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR046C"}


id: YOR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STD1","product":"Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]; STD1 has a paralog, MTH1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005573","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR047C"}


id: YOR048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02275":null,"YOR048C":null},"has_protein_features":false,"name":"RAT1","ortholog_annotations":[{"gene_uniquename":"YOR048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02275","reference_uniquename":"PMID:29761456"}],"product":"Nuclear 5' to 3' single-stranded RNA exonuclease; involved in RNA metabolism, including rRNA and snoRNA processing, as well as poly (A+) dependent and independent mRNA transcription termination; required for cotranscriptional pre-rRNA cleavage; displaces Cdk1p from elongating transcripts, especially as RNAPII reaches the poly(A) site, negatively regulates phosphorylation of the CTD of RNAPII, and inhibits RNAPII transcriptional elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005574","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR048C"}


id: YOR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00018":null,"SJAG_00587":null,"SJAG_00589":null,"SJAG_01095":null,"SJAG_02114":null,"SJAG_02132":null,"SJAG_02581":null,"SJAG_02943":null,"SJAG_02957":null,"YOR049C":null},"has_protein_features":false,"name":"RSB1","ortholog_annotations":[{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00018","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00587","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00589","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01095","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02114","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02132","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02581","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02943","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02957","reference_uniquename":"PMID:29761456"}],"product":"Sphingoid long-chain base (LCB) efflux transporter; integral membrane transporter that localizes to the plasma membrane and may transport long chain bases (LCBs) from the cytoplasmic side toward the extracytoplasmic side of the membrane; role in glycerophospholipid translocation; suppressor of the sphingoid LCB sensitivity of an LCB-lyase mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005575","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR049C"}


id: YOR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant is viable","secondary_identifier":"SGD:S000005576","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR050C"}


id: YOR051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01150":null,"YOR051C":null},"has_protein_features":false,"name":"ETT1","ortholog_annotations":[{"gene_uniquename":"YOR051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01150","reference_uniquename":"PMID:29761456"}],"product":"Nuclear protein that inhibits replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005577","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR051C"}


id: YOR052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04129":null,"YOR052C":null},"has_protein_features":false,"name":"TMC1","ortholog_annotations":[{"gene_uniquename":"YOR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04129","reference_uniquename":"PMID:29761456"}],"product":"AN1-type zinc finger protein, effector of proteotoxic stress response; stress-inducible transcriptional target of Rpn4p; induced by nitrogen limitation, weak acid, misfolded proteins; short-lived protein, degraded by proteasome; may protect cells from trivalent metalloid induced proteotoxicity; contains PACE promoter element; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases under DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005578","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR052C"}


id: YOR053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C","secondary_identifier":"SGD:S000005579","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR053W"}


id: YOR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VHS3","product":"Negative regulatory subunit of protein phosphatase 1 Ppz1p; involved in coenzyme A biosynthesis; subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p)","secondary_identifier":"SGD:S000005580","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR054C"}


id: YOR055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000005581","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR055W"}


id: YOR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03539":null,"YOR056C":null},"has_protein_features":false,"name":"NOB1","ortholog_annotations":[{"gene_uniquename":"YOR056C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03539","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005582","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR056C"}


id: YOR057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00574":null,"YOR057W":null},"has_protein_features":false,"name":"SGT1","ortholog_annotations":[{"gene_uniquename":"YOR057W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00574","reference_uniquename":"PMID:29761456"}],"product":"Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005583","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR057W"}


id: YOR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00723":null,"SJAG_03073":null,"YOR058C":null},"has_protein_features":false,"name":"ASE1","ortholog_annotations":[{"gene_uniquename":"YOR058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00723","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03073","reference_uniquename":"PMID:29761456"}],"product":"Mitotic spindle midzone-localized microtubule bundling protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005584","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR058C"}


id: YOR059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04973":null,"YOR059C":null},"has_protein_features":false,"name":"LPL1","ortholog_annotations":[{"gene_uniquename":"YOR059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04973","reference_uniquename":"PMID:29761456"}],"product":"Phospholipase; contains lipase specific GXSXG motif; maintains lipid droplet (LD) morphology; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005585","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR059C"}


id: YOR060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SLD7","product":"Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria; ortholog of human MTBP, which is a DNA replication origin firing factor","secondary_identifier":"SGD:S000005586","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR060C"}


id: YOR061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01799":null,"YOR061W":null},"has_protein_features":false,"name":"CKA2","ortholog_annotations":[{"gene_uniquename":"YOR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01799","reference_uniquename":"PMID:29761456"}],"product":"Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR061W"}


id: YOR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; similar to Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; YOR062C has a paralog, YKR075C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005588","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR062C"}


id: YOR063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01322":null,"SJAG_02611":null,"YOR063W":null},"has_protein_features":false,"name":"RPL3","ortholog_annotations":[{"gene_uniquename":"YOR063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01322","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02611","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; plays an important role in function of eIF5B in stimulating 3' end processing of 18S rRNA in context of 80S ribosomes that have not yet engaged in translation; involved in replication and maintenance of killer double stranded RNA virus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005589","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR063W"}


id: YOR064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03230":null,"SJAG_03628":null,"YOR064C":null},"has_protein_features":false,"name":"YNG1","ortholog_annotations":[{"gene_uniquename":"YOR064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03230","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR064C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03628","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3; shares significant sequence identity with the human candidate tumor suppressor p33-ING1 in C-terminal region","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005590","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR064C"}


id: YOR065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02646":null,"YOR065W":null},"has_protein_features":false,"name":"CYT1","ortholog_annotations":[{"gene_uniquename":"YOR065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02646","reference_uniquename":"PMID:29761456"}],"product":"Cytochrome c1; component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005591","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR065W"}


id: YOR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MSA1","product":"Activator of G1-specific transcription factors MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; MSA1 has a paralog, MSA2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005592","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR066W"}


id: YOR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01950":null,"YOR067C":null},"has_protein_features":false,"name":"ALG8","ortholog_annotations":[{"gene_uniquename":"YOR067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01950","reference_uniquename":"PMID:29761456"}],"product":"Glucosyl transferase; involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p; human homolog ALG8 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005593","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR067C"}


id: YOR068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VAM10","product":"Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering","secondary_identifier":"SGD:S000005594","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR068C"}


id: YOR069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01382":null,"SJAG_04275":null,"YOR069W":null},"has_protein_features":false,"name":"VPS5","ortholog_annotations":[{"gene_uniquename":"YOR069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01382","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YOR069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04275","reference_uniquename":"PMID:29761456"}],"product":"Nexin-1 homolog; required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to late Golgi; structural component of retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes; VPS5 has a paralog, YKR078W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000005595","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR069W"}


id: YOR070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04548":null,"YOR070C":null},"has_protein_features":false,"name":"GYP1","ortholog_annotations":[{"gene_uniquename":"YOR070C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04548","reference_uniquename":"PMID:29761456"}],"product":"Cis-golgi GTPase-activating protein (GAP) for yeast Rabs; the Rab family members are Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion; interacts with autophagosome component Atg8p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005596","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR070C"}


id: YOR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NRT1","product":"High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; major transporter for 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine) uptake; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity","secondary_identifier":"SGD:S000005597","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR071C"}


id: YOR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive","secondary_identifier":"SGD:S000005598","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR072W"}


id: YOR072W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028582","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR072W-A"}


id: YOR072W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028516","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR072W-B"}


id: YOR073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03989":null,"SJAG_04623":null,"YOR073W":null},"has_protein_features":false,"name":"SGO1","ortholog_annotations":[{"gene_uniquename":"YOR073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03989","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04623","reference_uniquename":"PMID:29761456"}],"product":"Component of the spindle checkpoint; involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; recruits condensin to the pericentric region of chromosomes during meiosis; dissociates from pericentromeres when sister kinetochores are under tension","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005599","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR073W"}


id: YOR073W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CDC21/YOR074C; identified by RT-PCR","secondary_identifier":"SGD:S000028583","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR073W-A"}


id: YOR074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04627":null,"YOR074C":null},"has_protein_features":false,"name":"CDC21","ortholog_annotations":[{"gene_uniquename":"YOR074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04627","reference_uniquename":"PMID:29761456"}],"product":"Thymidylate synthase; required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S; human homolog TYMSOS can complement yeast cdc21 temperature-sensitive mutant at restrictive temperature","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005600","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR074C"}


id: YOR075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04701":null,"YOR075W":null},"has_protein_features":false,"name":"UFE1","ortholog_annotations":[{"gene_uniquename":"YOR075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04701","reference_uniquename":"PMID:29761456"}],"product":"t-SNARE protein required for retrograde vesicular traffic; involved in Sey1p-independent homotypic ER fusion; required for efficient nuclear fusion during mating; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005601","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR075W"}


id: YOR076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00226":null,"YOR076C":null},"has_protein_features":false,"name":"SKI7","ortholog_annotations":[{"gene_uniquename":"YOR076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00226","reference_uniquename":"PMID:29761456"}],"product":"GTP-binding protein that couples the Ski complex and exosome; putative pseudo-translational GTPase involved in 3'-to-5' mRNA decay pathway; interacts with both the cytoplasmic exosome and the Ski complex; eRF3-like domain targets nonstop mRNA for degradation; null mutants have a superkiller phenotype; SKI7 has a paralog, HBS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005602","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR076C"}


id: YOR077W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03840":null,"YOR077W":null},"has_protein_features":false,"name":"RTS2","ortholog_annotations":[{"gene_uniquename":"YOR077W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03840","reference_uniquename":"PMID:29761456"}],"product":"Basic zinc-finger protein; similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005603","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR077W"}


id: YOR078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02662":null,"YOR078W":null},"has_protein_features":false,"name":"BUD21","ortholog_annotations":[{"gene_uniquename":"YOR078W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02662","reference_uniquename":"PMID:29761456"}],"product":"Component of small ribosomal subunit (SSU) processome; interacts with the U3 snoRNA (Snr17a/b); involved in rRNA processing and maturation; required post-transcriptionally for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; originally isolated as bud-site selection mutant that displays a random budding pattern; ortholog of human NOL7","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005604","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR078W"}


id: YOR079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATX2","product":"Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation","secondary_identifier":"SGD:S000005605","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR079C"}


id: YOR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01068":null,"YOR080W":null},"has_protein_features":false,"name":"DIA2","ortholog_annotations":[{"gene_uniquename":"YOR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01068","reference_uniquename":"PMID:29761456"}],"product":"Origin-binding F-box protein; forms SCF ubiquitin ligase complex with Skp1p and Cdc53p; functions in ubiquitination of silent chromatin structural protein Sir4p; required to target Cdc6p for destruction during G1 phase; required for deactivation of Rad53 checkpoint kinase, completion of DNA replication during recovery from DNA damage, assembly of RSC complex, RSC-mediated transcription regulation, and nucleosome positioning; involved in invasive and pseudohyphal growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005606","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR080W"}


id: YOR081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02089":null,"SJAG_02907":null,"YOR081C":null},"has_protein_features":false,"name":"TGL5","ortholog_annotations":[{"gene_uniquename":"YOR081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02089","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02907","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional triacylglycerol lipase and LPA acyltransferase; lipid particle-localized triacylglycerol (TAG) lipase involved in triacylglycerol mobilization; catalyzes acylation of lysophosphatidic acid (LPA); potential Cdc28p substrate; TGL5 has a paralog, TGL4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005607","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR081C"}


id: YOR082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR083W","secondary_identifier":"SGD:S000005608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR082C"}


id: YOR083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03845":null,"YOR083W":null},"has_protein_features":false,"name":"WHI5","ortholog_annotations":[{"gene_uniquename":"YOR083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03845","reference_uniquename":"PMID:29761456"}],"product":"Repressor of G1 transcription; binds to SCB binding factor (SBF) at SCB target promoters in early G1; WHI5 expression is repressed in M/early G phase; phosphorylation of Whi5p by G1 cyclin (Cln)/Cdc28p relieves repression and promoter binding by Whi5p, drives nuclear export, and contributes to both the determination of critical cell size at START and cell fate; dephosphorylated and re-imported into the nucleus post-START during the starvation response, reversing commitment","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR083W"}


id: YOR084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LPX1","product":"Peroxisomal matrix-localized lipase; required for normal peroxisome morphology; contains a peroxisomal targeting signal type 1 (PTS1) and a lipase motif; peroxisomal import requires the PTS1 receptor, Pex5p and self-interaction; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; oleic acid inducible","secondary_identifier":"SGD:S000005610","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR084W"}


id: YOR085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03333":null,"YOR085W":null},"has_protein_features":false,"name":"OST3","ortholog_annotations":[{"gene_uniquename":"YOR085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03333","reference_uniquename":"PMID:29761456"}],"product":"Gamma subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins including modification of Pmt2p at N131 and N403","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005611","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR085W"}


id: YOR086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01437":null,"SJAG_04413":null,"SJAG_04417":null,"YOR086C":null},"has_protein_features":false,"name":"TCB1","ortholog_annotations":[{"gene_uniquename":"YOR086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01437","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04413","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR086C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04417","reference_uniquename":"PMID:29761456"}],"product":"Lipid-binding ER tricalbin involved in ER-plasma membrane tethering; one of at least 7 proteins (Ice2p, Ist2p, Scs2/Scs22p, Tcb1-Tcb3p) that affect cER tethering and contact with the plasma membrane (PM); regulates PI4P levels by controlling access of the Sac1p phosphatase to its substrate PI4P in the PM; regulates PM phospholipid homeostasis; contains 3 calcium and lipid binding domains; localizes to the cortical ER and to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005612","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR086C"}


id: YOR087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YVC1","product":"Vacuolar cation channel; mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock","secondary_identifier":"SGD:S000005613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR087W"}


id: YOR088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YOR088W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YOR087W","secondary_identifier":"SGD:S000005614","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR088W"}


id: YOR089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01379":null,"YOR089C":null},"has_protein_features":false,"name":"VPS21","ortholog_annotations":[{"gene_uniquename":"YOR089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01379","reference_uniquename":"PMID:29761456"}],"product":"Endosomal Rab family GTPase; required for endocytic transport and sorting of vacuolar hydrolases; required for endosomal localization of the CORVET complex; required with YPT52 for MVB biogenesis and sorting; involved in autophagy and ionic stress tolerance; geranylgeranylation required for membrane association; protein abundance increases in response to DNA replication stress; mammalian Rab5 homolog; VPS21 has a paralog, YPT53, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005615","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR089C"}


id: YOR090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03310":null,"YOR090C":null},"has_protein_features":false,"name":"PTC5","ortholog_annotations":[{"gene_uniquename":"YOR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03310","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial type 2C protein phosphatase (PP2C); involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005616","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR090C"}


id: YOR091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01715":null,"YOR091W":null},"has_protein_features":false,"name":"TMA46","ortholog_annotations":[{"gene_uniquename":"YOR091W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01715","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005617","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR091W"}


id: YOR092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM3","product":"Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005618","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR092W"}


id: YOR093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00982":null,"SJAG_03731":null,"YOR093C":null},"has_protein_features":false,"name":"CMR2","ortholog_annotations":[{"gene_uniquename":"YOR093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00982","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03731","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in regulation of diacylglycerol lipids levels; deletion causes sensitivity to unfolded protein response-inducing agents","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR093C"}


id: YOR094W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01456":null,"YOR094W":null},"has_protein_features":false,"name":"ARF3","ortholog_annotations":[{"gene_uniquename":"YOR094W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01456","reference_uniquename":"PMID:29761456"}],"product":"Glucose-repressible ADP-ribosylation factor; GTPase of Ras superfamily involved in regulating cell polarity and invasive growth; localizes to dynamic spots at plasma membrane and modulates PtdIns(4,5)P2 levels to facilitate endocytosis; required for localization of endocytic protein Lsb5p to correct cortical site in cells; also has mRNA binding activity; homolog of mammalian Arf6","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005620","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR094W"}


id: YOR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00070":null,"YOR095C":null},"has_protein_features":false,"name":"RKI1","ortholog_annotations":[{"gene_uniquename":"YOR095C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00070","reference_uniquename":"PMID:29761456"}],"product":"Ribose-5-phosphate ketol-isomerase; catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005621","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR095C"}


id: YOR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02046":null,"YOR096W":null},"has_protein_features":false,"name":"RPS7A","ortholog_annotations":[{"gene_uniquename":"YOR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02046","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005622","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR096W"}


id: YOR097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene","secondary_identifier":"SGD:S000005623","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR097C"}


id: YOR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03729":null,"YOR098C":null},"has_protein_features":false,"name":"NUP1","ortholog_annotations":[{"gene_uniquename":"YOR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03729","reference_uniquename":"PMID:29761456"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of thenuclear pore complex (NPC) permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005624","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR098C"}


id: YOR099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"YOR099W":null},"has_protein_features":false,"name":"KTR1","ortholog_annotations":[{"gene_uniquename":"YOR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"}],"product":"Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005625","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR099W"}


id: YOR100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00543":null,"YOR100C":null},"has_protein_features":false,"name":"CRC1","ortholog_annotations":[{"gene_uniquename":"YOR100C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00543","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homolog SLC25A20 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR100C"}


id: YOR101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03453":null,"YOR101W":null},"has_protein_features":false,"name":"RAS1","ortholog_annotations":[{"gene_uniquename":"YOR101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03453","reference_uniquename":"PMID:29761456"}],"product":"GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in regulation of cell proliferation; localized to the plasma membrane; activated by increased levels of glycolysis intermediate fructose-1,6-bisphosphate; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress; RAS1 has a paralog, RAS2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR101W"}


id: YOR102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex","secondary_identifier":"SGD:S000005628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR102W"}


id: YOR103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01389":null,"YOR103C":null},"has_protein_features":false,"name":"OST2","ortholog_annotations":[{"gene_uniquename":"YOR103C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01389","reference_uniquename":"PMID:29761456"}],"product":"Non-catalytic epsilon subunit of the oligosaccharyltransferase (OST) complex; the OST complex catalyzes asparagine-linked glycosylation of newly synthesized proteins in the ER; forms a pocket with Wbp1p involved in binding terminal glucose units of the donor glycan; located in the ER lumen","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR103C"}


id: YOR104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PIN2","product":"Exomer-dependent cargo protein; induces appearance of [PIN+] prion when overproduced; prion-like domain serves as a retention signal in the trans-Golgi network; predicted to be palmitoylated","secondary_identifier":"SGD:S000005630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR104W"}


id: YOR105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels","secondary_identifier":"SGD:S000005631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR105W"}


id: YOR106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VAM3","product":"Syntaxin-like vacuolar t-SNARE; functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region","secondary_identifier":"SGD:S000005632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR106W"}


id: YOR107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RGS2","product":"Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p","secondary_identifier":"SGD:S000005633","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR107W"}


id: YOR108C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028711","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR108C-A"}


id: YOR108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02841":null,"YOR108W":null},"has_protein_features":false,"name":"LEU9","ortholog_annotations":[{"gene_uniquename":"YOR108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02841","reference_uniquename":"PMID:29761456"}],"product":"Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005634","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR108W"}


id: YOR109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00063":null,"SJAG_03375":null,"YOR109W":null},"has_protein_features":false,"name":"INP53","ortholog_annotations":[{"gene_uniquename":"YOR109W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00063","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR109W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03375","reference_uniquename":"PMID:29761456"}],"product":"Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; INP53 has a paralog, INP52, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005635","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR109W"}


id: YOR110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05339":null,"YOR110W":null},"has_protein_features":false,"name":"TFC7","ortholog_annotations":[{"gene_uniquename":"YOR110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05339","reference_uniquename":"PMID:29761456"}],"product":"RNA pol III transcription initiation factor complex (TFIIIC) subunit; part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; TFC7 has a paralog, YNL108C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005636","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR110W"}


id: YOR111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01651":null,"YOR111W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YOR111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01651","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005637","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR111W"}


id: YOR112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04622":null,"YOR112W":null},"has_protein_features":false,"name":"CEX1","ortholog_annotations":[{"gene_uniquename":"YOR112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04622","reference_uniquename":"PMID:29761456"}],"product":"Component of COPI-mediated trafficking and tRNA nuclear export; enables Rna1p to access and activate Gsp1p-GTP bound to the export receptor tRNA complex during aminoacylation-dependent tRNA export; copurifies with tRNA export receptors; interacts with COPI coat proteins and regulates Golgi-to-ER trafficking; membrane fraction associated; mutations in members of the homologous human SCY1-like (SCYL) family of pseudokinases are linked to peripheral neuropathy, cerebellar atrophy, ataxia and ALS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR112W"}


id: YOR113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AZF1","product":"Zinc-finger transcription factor; involved in the diauxic shift; activates transcription of genes involved in carbon metabolism and energy production on glucose, while it activates transcription of genes involved in cell wall organization and biogenesis on glycerol-lactate; may also function as a co-repressor; capable of forming the prion [AZF1+]; relocalizes to the cytosol in response to hypoxia; contains polyglutamine and polyasparagine domains","secondary_identifier":"SGD:S000005639","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR113W"}


id: YOR114W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CIM1","product":"Mitochondrial HMG-box protein; limits the copy number of mitochondrial DNA (mtDNA), antagonizing HMG-box containing protein Abf2p, a mtDNA packaging factor; localizes to the mitochondrial matrix; contains two HMG-boxes similar to Abf2p; null mutant is viable","secondary_identifier":"SGD:S000005640","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR114W"}


id: YOR115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02525":null,"YOR115C":null},"has_protein_features":false,"name":"TRS33","ortholog_annotations":[{"gene_uniquename":"YOR115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02525","reference_uniquename":"PMID:29761456"}],"product":"Core component of TRAPP complexes I, II and IV; transport protein particle (TRAPP) complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII, and IV); proposed subunit of a novel complex, TRAPPIV, that may function redundantly with TRAPPIII as a GEF that activates Ypt1 during autophagy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005641","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR115C"}


id: YOR116C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04934":null,"YOR116C":null},"has_protein_features":false,"name":"RPO31","ortholog_annotations":[{"gene_uniquename":"YOR116C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04934","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase III largest subunit C160; part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR116C"}


id: YOR117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01544":null,"YOR117W":null},"has_protein_features":false,"name":"RPT5","ortholog_annotations":[{"gene_uniquename":"YOR117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01544","reference_uniquename":"PMID:29761456"}],"product":"ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR117W"}


id: YOR118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03620":null,"YOR118W":null},"has_protein_features":false,"name":"RTC5","ortholog_annotations":[{"gene_uniquename":"YOR118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03620","reference_uniquename":"PMID:29761456"}],"product":"Protein that regulates the vacuolar V-ATPase; regulates the assembly state of the V-ATPase holoenzyme, promoting complex disassembly, and counteracting the function of the RAVE complex; interacts with V-ATPase subunits; vacuolar membrane localization requires N-myristoylation and an assembled V-ATPase; GFP-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity; member of a conserved family of TLDc domain proteins found in eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR118W"}


id: YOR119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05018":null,"YOR119C":null},"has_protein_features":false,"name":"RIO1","ortholog_annotations":[{"gene_uniquename":"YOR119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05018","reference_uniquename":"PMID:29761456"}],"product":"Serine kinase that controls cell cycle progression; represses rDNA transcription and promotes 20S pre-rRNA maturation; catalytic activity regulates its association with pre-40S particles where it prevents premature entry into translation; downregulates centromeric RNA levels, limits RNAPII accessibility, stimulates cenRNA degradation and promotes timely kinetochore assembly; autophosphorylates and phosphorylates Rpa43p in anaphase to remove Pol I from rDNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR119C"}


id: YOR120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02010":null,"YOR120W":null},"has_protein_features":false,"name":"GCY1","ortholog_annotations":[{"gene_uniquename":"YOR120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02010","reference_uniquename":"PMID:29761456"}],"product":"Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; human homolog AKR1B1 can complement yeast null mutant; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR120W"}


id: YOR121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W","secondary_identifier":"SGD:S000005647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR121C"}


id: YOR122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04982":null,"YOR122C":null},"has_protein_features":false,"name":"PFY1","ortholog_annotations":[{"gene_uniquename":"YOR122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04982","reference_uniquename":"PMID:29761456"}],"product":"Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress; highly conserved protein; human PFN1 (profilin 1) complements temperature sensitive pfy1 mutants, PFN1 mutations are a rare cause of ALS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005648","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR122C"}


id: YOR123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03118":null,"YOR123C":null},"has_protein_features":false,"name":"LEO1","ortholog_annotations":[{"gene_uniquename":"YOR123C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03118","reference_uniquename":"PMID:29761456"}],"product":"Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005649","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR123C"}


id: YOR124C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01528":null,"YOR124C":null},"has_protein_features":false,"name":"UBP2","ortholog_annotations":[{"gene_uniquename":"YOR124C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01528","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; controls K63 homeostasis during oxidative stress; deubiquitinates Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005650","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR124C"}


id: YOR125C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00459":null,"YOR125C":null},"has_protein_features":false,"name":"CAT5","ortholog_annotations":[{"gene_uniquename":"YOR125C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00459","reference_uniquename":"PMID:29761456"}],"product":"Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR125C"}


id: YOR126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01989":null,"YOR126C":null},"has_protein_features":false,"name":"IAH1","ortholog_annotations":[{"gene_uniquename":"YOR126C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01989","reference_uniquename":"PMID:29761456"}],"product":"Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR126C"}


id: YOR127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04522":null,"SJAG_04765":null,"YOR127W":null},"has_protein_features":false,"name":"RGA1","ortholog_annotations":[{"gene_uniquename":"YOR127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04522","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04765","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP); required for proper bud site selection; transiently localizes to previous cell division sites (bud scars; cytokinesis remnants), interacting with Nis1p and Nba1p, to prevent Cdc42p repolarization; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from the bud neck to cytoplasm upon DNA replication stress; contains N-terminal LIM domains and a C-terminal GAP domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005653","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR127W"}


id: YOR128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01081":null,"YOR128C":null},"has_protein_features":false,"name":"ADE2","ortholog_annotations":[{"gene_uniquename":"YOR128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01081","reference_uniquename":"PMID:29761456"}],"product":"Phosphoribosylaminoimidazole carboxylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005654","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR128C"}


id: YOR129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AFI1","product":"Arf3p polarization-specific docking factor; required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p","secondary_identifier":"SGD:S000005655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR129C"}


id: YOR130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00543":null,"YOR130C":null},"has_protein_features":false,"name":"ORT1","ortholog_annotations":[{"gene_uniquename":"YOR130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00543","reference_uniquename":"PMID:29761456"}],"product":"Ornithine transporter of the mitochondrial inner membrane; exports ornithine from mitochondria as part of arginine biosynthesis; functionally complemented by human ortholog, SLC25A15, which is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome, but HHH-associated variants fail to complement","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR130C"}


id: YOR131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000005657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR131C"}


id: YOR132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00971":null,"YOR132W":null},"has_protein_features":false,"name":"VPS17","ortholog_annotations":[{"gene_uniquename":"YOR132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00971","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the membrane-associated retromer complex; essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR132W"}


id: YOR133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01438":null,"SJAG_05332":null,"YOR133W":null},"has_protein_features":false,"name":"EFT1","ortholog_annotations":[{"gene_uniquename":"YOR133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01438","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05332","reference_uniquename":"PMID:29761456"}],"product":"Elongation factor 2 (eEF2, EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR133W"}


id: YOR134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04462":null,"YOR134W":null},"has_protein_features":false,"name":"BAG7","ortholog_annotations":[{"gene_uniquename":"YOR134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04462","reference_uniquename":"PMID:29761456"}],"product":"Rho GTPase activating protein (RhoGAP); stimulates the intrinsic GTPase activity of Rho1p, which plays a bud growth by regulating actin cytoskeleton organization and cell wall biosynthesis, resulting in the downregulation of Rho1p; structurally and functionally related to Sac7p; BAG7 has a paralog, SAC7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR134W"}


id: YOR135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC14","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci","secondary_identifier":"SGD:S000005661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR135C"}


id: YOR136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IDH2","product":"Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes oxidation of isocitrate to alpha-ketoglutarate in TCA cycle; targeted to vacuole via AP-3 pathway","secondary_identifier":"SGD:S000005662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR136W"}


id: YOR137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04262":null,"YOR137C":null},"has_protein_features":false,"name":"SIA1","ortholog_annotations":[{"gene_uniquename":"YOR137C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04262","reference_uniquename":"PMID:29761456"}],"product":"Protein of unassigned function; involved in activation of the Pma1p plasma membrane H+-ATPase by glucose; contains peptide signal for membrane localization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005663","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR137C"}


id: YOR138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01342":null,"YOR138C":null},"has_protein_features":false,"name":"RUP1","ortholog_annotations":[{"gene_uniquename":"YOR138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01342","reference_uniquename":"PMID:29761456"}],"product":"Protein that regulates ubiquitination of Rsp5p; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005664","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR138C"}


id: YOR139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W","secondary_identifier":"SGD:S000005665","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR139C"}


id: YOR140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02472":null,"SJAG_04388":null,"YOR140W":null},"has_protein_features":false,"name":"SFL1","ortholog_annotations":[{"gene_uniquename":"YOR140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02472","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04388","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; has direct role in INO1 transcriptional memory; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p; premature stop codon (C1430T, Q477-stop) in SK1 background is linked to the aggressively invasive phenotype of SK1 relative to BY4741 (S288C)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005666","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR140W"}


id: YOR141C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01611":null,"YOR141C":null},"has_protein_features":false,"name":"ARP8","ortholog_annotations":[{"gene_uniquename":"YOR141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01611","reference_uniquename":"PMID:29761456"}],"product":"Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; has mRNA binding activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005667","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR141C"}


id: YOR142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01524":null,"YOR142W":null},"has_protein_features":false,"name":"LSC1","ortholog_annotations":[{"gene_uniquename":"YOR142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01524","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005668","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR142W"}


id: YOR143C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03362":null,"YOR143C":null},"has_protein_features":false,"name":"THI80","ortholog_annotations":[{"gene_uniquename":"YOR143C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03362","reference_uniquename":"PMID:29761456"}],"product":"Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR143C"}


id: YOR144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04150":null,"YOR144C":null},"has_protein_features":false,"name":"ELG1","ortholog_annotations":[{"gene_uniquename":"YOR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04150","reference_uniquename":"PMID:29761456"}],"product":"Subunit of an alternative replication factor C complex; important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005670","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR144C"}


id: YOR145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03872":null,"YOR145C":null},"has_protein_features":false,"name":"PNO1","ortholog_annotations":[{"gene_uniquename":"YOR145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03872","reference_uniquename":"PMID:29761456"}],"product":"Essential nucleolar protein required for pre-18S rRNA processing; interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR145C"}


id: YOR146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C","secondary_identifier":"SGD:S000005672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR146W"}


id: YOR147W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03395":null,"YOR147W":null},"has_protein_features":false,"name":"MDM32","ortholog_annotations":[{"gene_uniquename":"YOR147W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03395","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein with similarity to Mdm31p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34; variation between SK1 and S288C at residues 182 and 262 impacts invasive growth and mitochondrial network structure","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR147W"}


id: YOR148C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01557":null,"YOR148C":null},"has_protein_features":false,"name":"SPP2","ortholog_annotations":[{"gene_uniquename":"YOR148C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01557","reference_uniquename":"PMID:29761456"}],"product":"Essential protein that promotes the first step of splicing; required for the final stages of spliceosome maturation and activation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction; stimulates Prp2p ATPase activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005674","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR148C"}


id: YOR149C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03878":null,"YOR149C":null},"has_protein_features":false,"name":"SMP3","ortholog_annotations":[{"gene_uniquename":"YOR149C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03878","reference_uniquename":"PMID:29761456"}],"product":"Alpha 1,2-mannosyltransferase; involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005675","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR149C"}


id: YOR150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03176":null,"YOR150W":null},"has_protein_features":false,"name":"MRPL23","ortholog_annotations":[{"gene_uniquename":"YOR150W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03176","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR150W"}


id: YOR151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04030":null,"YOR151C":null},"has_protein_features":false,"name":"RPB2","ortholog_annotations":[{"gene_uniquename":"YOR151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04030","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR151C"}


id: YOR152C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG40","product":"Autophagy receptor with a role in endoplasmic reticulum degradation; involved specifically in autophagy of cortical and cytoplasmic ER in response to nitrogen starvation or rapamycin treatment; acts with COPII subunit Sfb3p; localizes to the cortical and cytoplasmic ER; similar to human FAM134B, which is also involved in ER autophagy and is associated with sensory neuropathy","secondary_identifier":"SGD:S000005678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR152C"}


id: YOR153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04277":null,"YOR153W":null},"has_protein_features":false,"name":"PDR5","ortholog_annotations":[{"gene_uniquename":"YOR153W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04277","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth; PDR5 has a paralog, PDR15, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005679","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR153W"}


id: YOR154W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02032":null,"YOR154W":null},"has_protein_features":false,"name":"SLP1","ortholog_annotations":[{"gene_uniquename":"YOR154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02032","reference_uniquename":"PMID:29761456"}],"product":"Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005680","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR154W"}


id: YOR155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03096":null,"YOR155C":null},"has_protein_features":false,"name":"ISN1","ortholog_annotations":[{"gene_uniquename":"YOR155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03096","reference_uniquename":"PMID:29761456"}],"product":"Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase; catalyzes the breakdown of IMP to inosine; responsible for production of nicotinamide riboside and nicotinic acid riboside; tetrameric form negatively regulated by inosine and ATP; expression positively regulated by nicotinic acid and glucose availability; does not show similarity to known 5'-nucleotidases from other organisms","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005681","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR155C"}


id: YOR156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00727":null,"YOR156C":null},"has_protein_features":false,"name":"NFI1","ortholog_annotations":[{"gene_uniquename":"YOR156C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00727","reference_uniquename":"PMID:29761456"}],"product":"SUMO E3 ligase; catalyzes sumoylation of Yku70p/80p and Sir4p promoting telomere anchoring to the nuclear envelope and regulating telomerase activity; DNA-bound form catalyzes a DNA-damaged triggered sumoylation wave resulting in multisite modification of several DNA repair proteins, enhancing interactions between these proteins and accelerating repair; sumoylates Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; role in telomere length maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005682","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR156C"}


id: YOR157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01014":null,"YOR157C":null},"has_protein_features":false,"name":"PUP1","ortholog_annotations":[{"gene_uniquename":"YOR157C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01014","reference_uniquename":"PMID:29761456"}],"product":"Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005683","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR157C"}


id: YOR158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00148":null,"YOR158W":null},"has_protein_features":false,"name":"PET123","ortholog_annotations":[{"gene_uniquename":"YOR158W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00148","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR158W"}


id: YOR159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03469":null,"YOR159C":null},"has_protein_features":false,"name":"SME1","ortholog_annotations":[{"gene_uniquename":"YOR159C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03469","reference_uniquename":"PMID:29761456"}],"product":"Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005685","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR159C"}


id: YOR160W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03470":null,"YOR160W":null},"has_protein_features":false,"name":"MTR10","ortholog_annotations":[{"gene_uniquename":"YOR160W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03470","reference_uniquename":"PMID:29761456"}],"product":"Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005686","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR160W"}


id: YOR161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00763":null,"YOR161C":null},"has_protein_features":false,"name":"PNS1","ortholog_annotations":[{"gene_uniquename":"YOR161C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00763","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005687","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR161C"}


id: YOR161C-C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028712","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR161C-C"}


id: YOR161W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028713","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR161W-A"}


id: YOR161W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028714","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR161W-B"}


id: YOR162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YRR1","product":"Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000005688","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR162C"}


id: YOR163W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04870":null,"YOR163W":null},"has_protein_features":false,"name":"DDP1","ortholog_annotations":[{"gene_uniquename":"YOR163W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04870","reference_uniquename":"PMID:29761456"}],"product":"Diadenosine and diphosphoinositol polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005689","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR163W"}


id: YOR164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03865":null,"YOR164C":null},"has_protein_features":false,"name":"GET4","ortholog_annotations":[{"gene_uniquename":"YOR164C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03865","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005690","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR164C"}


id: YOR165W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02595":null,"YOR165W":null},"has_protein_features":false,"name":"SEY1","ortholog_annotations":[{"gene_uniquename":"YOR165W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02595","reference_uniquename":"PMID:29761456"}],"product":"Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005691","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR165W"}


id: YOR166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04198":null,"YOR166C":null},"has_protein_features":false,"name":"SWT1","ortholog_annotations":[{"gene_uniquename":"YOR166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04198","reference_uniquename":"PMID:29761456"}],"product":"RNA endoribonuclease involved in perinuclear mRNP quality control; involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005692","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR166C"}


id: YOR167C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02749":null,"SJAG_04746":null,"YOR167C":null},"has_protein_features":false,"name":"RPS28A","ortholog_annotations":[{"gene_uniquename":"YOR167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02749","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YOR167C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04746","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; has an extraribosomal function in regulation of RPS28B, in which Rps28Ap binds to a decapping complex via Edc3p, which then binds to RPS28B mRNA leading to its decapping and degradation; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28A has a paralog, RPS28B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005693","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR167C"}


id: YOR168W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04482":null,"YOR168W":null},"has_protein_features":false,"name":"GLN4","ortholog_annotations":[{"gene_uniquename":"YOR168W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04482","reference_uniquename":"PMID:29761456"}],"product":"Glutamine tRNA synthetase; monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Gln); N-terminal domain proposed to be involved in enzyme-tRNA interactions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005694","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR168W"}


id: YOR169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W","secondary_identifier":"SGD:S000005695","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR169C"}


id: YOR170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4","secondary_identifier":"SGD:S000005696","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR170W"}


id: YOR171C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02429":null,"YOR171C":null},"has_protein_features":false,"name":"LCB4","ortholog_annotations":[{"gene_uniquename":"YOR171C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02429","reference_uniquename":"PMID:29761456"}],"product":"Sphingoid long-chain base kinase; responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes; LCB4 has a paralog, LCB5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005697","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR171C"}


id: YOR172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YRM1","product":"Zinc finger transcription factor involved in multidrug resistance; Zn(2)-Cys(6) zinc finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes","secondary_identifier":"SGD:S000005698","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR172W"}


id: YOR173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01625":null,"YOR173W":null},"has_protein_features":false,"name":"DCS2","ortholog_annotations":[{"gene_uniquename":"YOR173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01625","reference_uniquename":"PMID:29761456"}],"product":"m(7)GpppX pyrophosphatase regulator; non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance; DCS2 has a paralog, DCS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005699","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR173W"}


id: YOR174W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00297":null,"YOR174W":null},"has_protein_features":false,"name":"MED4","ortholog_annotations":[{"gene_uniquename":"YOR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00297","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005700","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR174W"}


id: YOR175C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04792":null,"YOR175C":null},"has_protein_features":false,"name":"ALE1","ortholog_annotations":[{"gene_uniquename":"YOR175C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04792","reference_uniquename":"PMID:29761456"}],"product":"Broad-specificity lysophospholipid acyltransferase; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005701","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR175C"}


id: YOR176W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01841":null,"YOR176W":null},"has_protein_features":false,"name":"HEM15","ortholog_annotations":[{"gene_uniquename":"YOR176W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01841","reference_uniquename":"PMID:29761456"}],"product":"Ferrochelatase; a mitochondrial inner membrane protein, catalyzes insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; human homolog FECH can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000005702","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YOR176W"}


