# genes

id: YKR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05266":null,"YKR037C":null},"has_protein_features":false,"name":"SPC34","ortholog_annotations":[{"gene_uniquename":"YKR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05266","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001745","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR037C"}


id: YKR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04182":null,"YKR038C":null},"has_protein_features":false,"name":"KAE1","ortholog_annotations":[{"gene_uniquename":"YKR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04182","reference_uniquename":"PMID:29761456"}],"product":"ADP/GDP nucleotidase, essential functional component of KEOPS complex, with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; homolog of human OSGEP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001746","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR038C"}


id: YKR039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00149":null,"SJAG_01998":null,"SJAG_02150":null,"SJAG_02946":null,"SJAG_02947":null,"SJAG_03827":null,"SJAG_04296":null,"SJAG_04637":null,"SJAG_05342":null,"YKR039W":null},"has_protein_features":false,"name":"GAP1","ortholog_annotations":[{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00149","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01998","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02150","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02946","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02947","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03827","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04296","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04637","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR039W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05342","reference_uniquename":"PMID:29761456"}],"product":"General amino acid permease; involved in uptake of all L-amino acids, some D-amino acids, related compounds, toxic analogs and polyamines; regulated by nitrogen source; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; essential for invasive growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001747","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR039W"}


id: YKR040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W","secondary_identifier":"SGD:S000001748","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR040C"}


id: YKR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking","secondary_identifier":"SGD:S000001749","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR041W"}


id: YKR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02649":null,"SJAG_03295":null,"YKR042W":null},"has_protein_features":false,"name":"UTH1","ortholog_annotations":[{"gene_uniquename":"YKR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02649","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03295","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein; role in mitophagy is disputed; implicated in cell wall biogenesis, the oxidative stress response, life span during starvation, and cell death; SUN family member; UTH1 has a paralog, NCA3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001750","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR042W"}


id: YKR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SHB17","product":"Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus","secondary_identifier":"SGD:S000001751","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR043C"}


id: YKR044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01991":null,"YKR044W":null},"has_protein_features":false,"name":"UIP5","ortholog_annotations":[{"gene_uniquename":"YKR044W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01991","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function that interacts with Ulp1p; a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001752","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR044W"}


id: YKR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm","secondary_identifier":"SGD:S000001753","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR045C"}


id: YKR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PLN1","product":"Perilipin, involved in formation and stability of lipid droplets; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange","secondary_identifier":"SGD:S000001754","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR046C"}


id: YKR047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1","secondary_identifier":"SGD:S000001755","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR047W"}


id: YKR048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00942":null,"SJAG_02314":null,"YKR048C":null},"has_protein_features":false,"name":"NAP1","ortholog_annotations":[{"gene_uniquename":"YKR048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00942","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02314","reference_uniquename":"PMID:29761456"}],"product":"Histone chaperone and assembly chaperone for Rps6a/b; involved in histone exchange, replacing histone H2A-H2B dimers or histone variant dimers from assembled nucleosomes; promotes solubility of Rps6a, and 40S ribosomal subunit biogenesis; role in transport of H2A and H2B histones to the nucleus; regulates microtubule dynamics during mitosis; interacts with mitotic cyclin Clb2p; controls bud morphogenesis; phosphorylated by CK2; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001756","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR048C"}


id: YKR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMP46","product":"Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000001757","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR049C"}


id: YKR050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01353":null,"SJAG_02883":null,"YKR050W":null},"has_protein_features":false,"name":"TRK2","ortholog_annotations":[{"gene_uniquename":"YKR050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01353","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02883","reference_uniquename":"PMID:29761456"}],"product":"Component of the Trk1p-Trk2p potassium transport system; contributes to K(+) supply and maintenance of plasma-membrane potential; TRK2 has a paralog, TRK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001758","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR050W"}


id: YKR051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03725":null,"YKR051W":null},"has_protein_features":false,"name":"HFL1","ortholog_annotations":[{"gene_uniquename":"YKR051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03725","reference_uniquename":"PMID:29761456"}],"product":"Vacuole membrane protein that interacts with Atg8p; functions in the vacuolar membrane recruitment of Atg8p to facilitate the degradation of vacuolar integral membrane proteins during early-stationary vacuole turnover (EVT), a general degradation process for vacuolar integral membrane proteins when cells enter stationary phase; null mutant is defective in stationary phase-induced vacuolar microdomain formation; homolog of S. pombe hfl1; homolog of human TMEM184","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001759","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR051W"}


id: YKR052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02473":null,"SJAG_04737":null,"YKR052C":null},"has_protein_features":false,"name":"MRS4","ortholog_annotations":[{"gene_uniquename":"YKR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02473","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04737","reference_uniquename":"PMID:29761456"}],"product":"Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001760","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR052C"}


id: YKR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04986":null,"YKR053C":null},"has_protein_features":false,"name":"YSR3","ortholog_annotations":[{"gene_uniquename":"YKR053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04986","reference_uniquename":"PMID:29761456"}],"product":"Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001761","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR053C"}


id: YKR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02286":null,"YKR054C":null},"has_protein_features":false,"name":"DYN1","ortholog_annotations":[{"gene_uniquename":"YKR054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02286","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001762","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR054C"}


id: YKR055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01774":null,"YKR055W":null},"has_protein_features":false,"name":"RHO4","ortholog_annotations":[{"gene_uniquename":"YKR055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01774","reference_uniquename":"PMID:29761456"}],"product":"Non-essential small GTPase; member of the Rho/Rac subfamily of Ras-like proteins; likely to be involved in the establishment of cell polarity; has long N-terminal extension that plays an important role in Rho4p function and is shared with Rho4 homologs in other yeasts and filamentous fungi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001763","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR055W"}


id: YKR056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04736":null,"YKR056W":null},"has_protein_features":false,"name":"TRM2","ortholog_annotations":[{"gene_uniquename":"YKR056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04736","reference_uniquename":"PMID:29761456"}],"product":"tRNA methyltransferase; 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; involved in the methylation of guanosine and uridine ribonucleosides in mRNA; endo-exonuclease with a role in DNA repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001764","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR056W"}


id: YKR057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04174":null,"YKR057W":null},"has_protein_features":false,"name":"RPS21A","ortholog_annotations":[{"gene_uniquename":"YKR057W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04174","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001765","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR057W"}


id: YKR058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GLG1","product":"Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole respectively; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001766","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR058W"}


id: YKR059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04772":null,"YKR059W":null},"has_protein_features":false,"name":"TIF1","ortholog_annotations":[{"gene_uniquename":"YKR059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04772","reference_uniquename":"PMID:29761456"}],"product":"Translation initiation factor eIF4A; DEAD-box RNA helicase that couples ATPase activity to mRNA binding and unwinding; ATP hydrolysis accelerates the recruitment of mRNA during 48S preinitiation complex (PIC) assembly; ATPase activity stimulated by either eIF4G1 or by the PIC in an eIF3g and eIFGi subunit-dependent manner, independent of eIF4E and eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E and eIF4G; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001767","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR059W"}


id: YKR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01420":null,"SJAG_01752":null,"YKR060W":null},"has_protein_features":false,"name":"UTP30","ortholog_annotations":[{"gene_uniquename":"YKR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01420","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01752","reference_uniquename":"PMID:29761456"}],"product":"Subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit; Utp30p is peripherally associated with 90S preribosome and appears partially redundant with its paralog Cic1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001768","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR060W"}


id: YKR061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"YKR061W":null},"has_protein_features":false,"name":"KTR2","ortholog_annotations":[{"gene_uniquename":"YKR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"}],"product":"Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001769","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR061W"}


id: YKR062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00159":null,"YKR062W":null},"has_protein_features":false,"name":"TFA2","ortholog_annotations":[{"gene_uniquename":"YKR062W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00159","reference_uniquename":"PMID:29761456"}],"product":"TFIIE small subunit; involved in RNA polymerase II transcription initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001770","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR062W"}


id: YKR063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01581":null,"YKR063C":null},"has_protein_features":false,"name":"LAS1","ortholog_annotations":[{"gene_uniquename":"YKR063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01581","reference_uniquename":"PMID:29761456"}],"product":"Endonuclease involved in pre-rRNA processing at both ends of ITS2; functions with Grc3p in a conserved mechanism to cleave pre-rRNA at a specific site during rRNA processing and ribosome biogenesis; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S cell cycle transition; human ortholog is Las1L; mutants require the SSD1-v allele for viability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001771","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR063C"}


id: YKR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OAF3","product":"Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress","secondary_identifier":"SGD:S000001772","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR064W"}


id: YKR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04432":null,"YKR065C":null},"has_protein_features":false,"name":"PAM17","ortholog_annotations":[{"gene_uniquename":"YKR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04432","reference_uniquename":"PMID:29761456"}],"product":"Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001773","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR065C"}


id: YKR066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CCP1","product":"Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria; acts as hydrogen peroxide sensor in mitochondria, involved in the response to oxidative stress","secondary_identifier":"SGD:S000001774","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR066C"}


id: YKR067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02654":null,"SJAG_03305":null,"YKR067W":null},"has_protein_features":false,"name":"GPT2","ortholog_annotations":[{"gene_uniquename":"YKR067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02654","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR067W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03305","reference_uniquename":"PMID:26896847"}],"product":"Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001775","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR067W"}


id: YKR068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01415":null,"YKR068C":null},"has_protein_features":false,"name":"BET3","ortholog_annotations":[{"gene_uniquename":"YKR068C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01415","reference_uniquename":"PMID:29761456"}],"product":"Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); hydrophilic homodimeric protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001776","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR068C"}


id: YKR069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01192":null,"YKR069W":null},"has_protein_features":false,"name":"MET1","ortholog_annotations":[{"gene_uniquename":"YKR069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01192","reference_uniquename":"PMID:29761456"}],"product":"S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001777","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR069W"}


id: YKR070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04317":null,"YKR070W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YKR070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04317","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001778","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR070W"}


id: YKR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00455":null,"YKR071C":null},"has_protein_features":false,"name":"DRE2","ortholog_annotations":[{"gene_uniquename":"YKR071C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00455","reference_uniquename":"PMID:29761456"}],"product":"Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18p in an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress; inviability of the null mutant is functionally complemented by human CIAPIN1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001779","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR071C"}


id: YKR072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SIS2","product":"Negative regulatory subunit of protein phosphatase 1 (Ppz1p); involved in coenzyme A biosynthesis; subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC: Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p); dose-dependent regulator of replicative lifespan; SIS2 has a paralog, VHS3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001780","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR072C"}


id: YKR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000001781","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR073C"}


id: YKR074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04741":null,"YKR074W":null},"has_protein_features":false,"name":"AIM29","ortholog_annotations":[{"gene_uniquename":"YKR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04741","reference_uniquename":"PMID:29761456"}],"product":"Zpr1p co-chaperone; recognizes eEF1A in GTP-bound, pre-hydrolysis conformation, dampens folding complex GTPase activity to drive client release from Zpr1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001782","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR074W"}


id: YKR075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; similar to Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; YKR075C has a paralog, YOR062C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001783","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR075C"}


id: YKR075W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a protein; completely overlaps the uncharacterized gene YKR075C; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR075W-A"}


id: YKR076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM4","product":"S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR); glutathione transferase involved in cell-surface biosynthesis and architecture; catalyzes glutathione (GSH)-dependent reduction of GS-trichloro-p-hydroquinone to trichloro-p-hydroquinone; expression upregulated upon exposure to genotoxic agents, such as methyl methanesulfonate, cisplatin and bleomycin; not an essential gene; similar to YGR154C; green fluorescent protein (GFP)-fusion protein localizes to cytoplasm","secondary_identifier":"SGD:S000001784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR076W"}


id: YKR077W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MSA2","product":"Putative transcriptional activator; interacts with G1-specific transcription factor MBF and G1-specific promoters; MSA2 has a paralog, MSA1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001785","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR077W"}


id: YKR078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VPS501","product":"Vacuolar SNX-BAR protein, regulates TORC1 signaling during autophagy induction; binds phosphatidylinositol-3-phosphate; vacuolar localization of Vps501p is dependent upon direct interaction with Iml1p and a unique lipid binding specificity that is also required for its function; VPS501 has paralog VPS5 that arose from the whole genome duplication","secondary_identifier":"SGD:S000001786","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR078W"}


id: YKR079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00997":null,"SJAG_04885":null,"YKR079C":null},"has_protein_features":false,"name":"TRZ1","ortholog_annotations":[{"gene_uniquename":"YKR079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00997","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR079C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04885","reference_uniquename":"PMID:29761456"}],"product":"tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001787","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR079C"}


id: YKR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01126":null,"YKR080W":null},"has_protein_features":false,"name":"MTD1","ortholog_annotations":[{"gene_uniquename":"YKR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01126","reference_uniquename":"PMID:29761456"}],"product":"NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase; plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001788","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR080W"}


id: YKR081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04108":null,"YKR081C":null},"has_protein_features":false,"name":"RPF2","ortholog_annotations":[{"gene_uniquename":"YKR081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04108","reference_uniquename":"PMID:29761456"}],"product":"Essential protein involved in rRNA maturation and ribosomal assembly; involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001789","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR081C"}


id: YKR082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01374":null,"SJAG_03986":null,"YKR082W":null},"has_protein_features":false,"name":"NUP133","ortholog_annotations":[{"gene_uniquename":"YKR082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01374","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03986","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Nup84p subcomplex of nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis; is involved in establishment of a normal nucleocytoplasmic concentration gradient of GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at nuclear periphery, including double-strand break repair, transcription and chromatin silencing; relocalizes to cytosol in response to hypoxia; homolog of human NUP133","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001790","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR082W"}


id: YKR083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01371":null,"YKR083C":null},"has_protein_features":false,"name":"DAD2","ortholog_annotations":[{"gene_uniquename":"YKR083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01371","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001791","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR083C"}


id: YKR084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02601":null,"YKR084C":null},"has_protein_features":false,"name":"HBS1","ortholog_annotations":[{"gene_uniquename":"YKR084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02601","reference_uniquename":"PMID:29761456"}],"product":"GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, particularly in 3' UTRs; genetically implicated in mRNA no-go decay; HBS1 has a paralog, SKI7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001792","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR084C"}


id: YKR085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04244":null,"YKR085C":null},"has_protein_features":false,"name":"MRPL20","ortholog_annotations":[{"gene_uniquename":"YKR085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04244","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001793","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR085C"}


id: YKR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01152":null,"YKR086W":null},"has_protein_features":false,"name":"PRP16","ortholog_annotations":[{"gene_uniquename":"YKR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01152","reference_uniquename":"PMID:29761456"}],"product":"DEAH-box RNA helicase; involved in the second catalytic step of splicing and in exon ligation; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step; missense mutation in human ortholog DHX38 associated with early-onset retinitis pigmentosa","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001794","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR086W"}


id: YKR087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04514":null,"YKR087C":null},"has_protein_features":false,"name":"OMA1","ortholog_annotations":[{"gene_uniquename":"YKR087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04514","reference_uniquename":"PMID:29761456"}],"product":"Metalloendopeptidase of the mitochondrial inner membrane; important for adaptive responses to various homeostatic insults, preservation of normal mitochondrial function under damage-eliciting conditions, and stability of respiratory supercomplexes; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; zebrafish ortholog has a role in organ development and mouse ortholog is also required for respiratory supercomplex stability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001795","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR087C"}


id: YKR088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01133":null,"YKR088C":null},"has_protein_features":false,"name":"TVP38","ortholog_annotations":[{"gene_uniquename":"YKR088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01133","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001796","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR088C"}


id: YKR089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02089":null,"SJAG_02907":null,"YKR089C":null},"has_protein_features":false,"name":"TGL4","ortholog_annotations":[{"gene_uniquename":"YKR089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02089","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02907","reference_uniquename":"PMID:29761456"}],"product":"Multifunctional lipase/hydrolase/phospholipase; triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p; TGL4 has a paralog, TGL5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001797","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR089C"}


id: YKR090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02831":null,"YKR090W":null},"has_protein_features":false,"name":"PXL1","ortholog_annotations":[{"gene_uniquename":"YKR090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02831","reference_uniquename":"PMID:29761456"}],"product":"Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001798","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR090W"}


id: YKR091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SRL3","product":"Transcriptional repressor at START; binds to SBF (Swi4p-Swi6p) at SCB promoter elements in G1 to repress transcription; START inhibitor that retains Cdc28-Cln3 at the ER; acts with Ydj1p to promote release of the complex in a growth-mediated positive feedback loop to trigger START; unstable and degraded by SCF-Grr1 after phosphorylation; contains a G1/S transcription factor binding (GTB) motif; binds SBF-regulated promoters in HU-treated cells; substrate of Cdc28p and Pho85p; hyperphosphorylated","secondary_identifier":"SGD:S000001799","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR091W"}


id: YKR092C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01125":null,"YKR092C":null},"has_protein_features":false,"name":"SRP40","ortholog_annotations":[{"gene_uniquename":"YKR092C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01125","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar serine-rich protein; role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001800","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR092C"}


id: YKR093W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01983":null,"YKR093W":null},"has_protein_features":false,"name":"PTR2","ortholog_annotations":[{"gene_uniquename":"YKR093W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01983","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by N-end rule pathway via repression by Cup9p; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001801","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR093W"}


id: YKR094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01365":null,"SJAG_02891":null,"SJAG_03971":null,"YKR094C":null},"has_protein_features":false,"name":"RPL40B","ortholog_annotations":[{"gene_uniquename":"YKR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01365","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02891","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03971","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001802","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR094C"}


id: YKR095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03300":null,"SJAG_04645":null,"YKR095W":null},"has_protein_features":false,"name":"MLP1","ortholog_annotations":[{"gene_uniquename":"YKR095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03300","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YKR095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04645","reference_uniquename":"PMID:29761456"}],"product":"Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs; MLP1 has a paralog, MLP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001803","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR095W"}


id: YKR095W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02863":null,"YKR095W-A":null},"has_protein_features":false,"name":"PCC1","ortholog_annotations":[{"gene_uniquename":"YKR095W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02863","reference_uniquename":"PMID:29761456"}],"product":"Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; other complex members are Kae1p, Gon7p, Bud32p, and Cgi121p; ortholog of human LAGE3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028512","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR095W-A"}


id: YKR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01720":null,"YKR096W":null},"has_protein_features":false,"name":"ESL2","ortholog_annotations":[{"gene_uniquename":"YKR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01720","reference_uniquename":"PMID:29761456"}],"product":"hEST1A/B (SMG5/6)-like protein; contributes to environment-sensing adaptive gene expression responses; Esl2p and Esl1p contain a 14-3-3-like domain and a putative PilT N-terminus ribonuclease domain; interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; ESL2 has a paralog, ESL1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001804","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR096W"}


id: YKR097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PCK1","product":"Phosphoenolpyruvate carboxykinase; key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol","secondary_identifier":"SGD:S000001805","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR097W"}


id: YKR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UBP11","product":"Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; UBP11 has a paralog, UBP7, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR098C"}


id: YKR099C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a protein; YKR099C-A was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YKR100C","secondary_identifier":"SGD:S000028842","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR099C-A"}


id: YKR099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BAS1","product":"Myb-related transcription factor; involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; controls cellular ATP levels; also involved in regulation of meiotic recombination at specific genes","secondary_identifier":"SGD:S000001807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR099W"}


id: YKR100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SKG1","product":"Transmembrane protein with a role in cell wall polymer composition; localizes on inner surface of plasma membrane at bud and in daughter cell; SKG1 has a paralog, AIM20, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR100C"}


id: YKR101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SIR1","product":"Protein involved in silencing at mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin","secondary_identifier":"SGD:S000001809","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR101W"}


id: YKR102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FLO10","product":"Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth","secondary_identifier":"SGD:S000001810","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR102W"}


id: YKR103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NFT1","product":"Putative transporter of the MRP subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; MRP stands for multidrug resistance-associated protein","secondary_identifier":"SGD:S000001811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR103W"}


id: YKR104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative transporter of the MRP subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; MRP stands for multidrug resistance-associated protein","secondary_identifier":"SGD:S000001812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR104W"}


id: YKR105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01336":null,"SJAG_01636":null,"SJAG_01923":null,"SJAG_04983":null,"YKR105C":null},"has_protein_features":false,"name":"VBA5","ortholog_annotations":[{"gene_uniquename":"YKR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01336","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01636","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01923","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04983","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; VBA5 has a paralog, VBA3, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001813","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR105C"}


id: YKR106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YKR106W":null},"has_protein_features":false,"name":"GEX2","ortholog_annotations":[{"gene_uniquename":"YKR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YKR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; expressed at a very low level; potential role in resistance to oxidative stress and modulation of the PKA pathway; GEX2 has a paralog, GEX1, that arose from a segmental duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001814","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YKR106W"}


id: YLL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02848":null,"YLL001W":null},"has_protein_features":false,"name":"DNM1","ortholog_annotations":[{"gene_uniquename":"YLL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02848","reference_uniquename":"PMID:29761456"}],"product":"Dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and inheritance; self assembles on the cytoplasmic face of mitochondrial tubules at sites where division will occur; participates in endocytosis and regulates peroxisome fission along with Vps1p; mutants in the human ortholog DNM1L, which mediates mitochondrial fission, peroxisomal division, autophagy, and mitophagy, are associated with slowly progressive infantile encephalopathy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003924","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL001W"}


id: YLL002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01204":null,"YLL002W":null},"has_protein_features":false,"name":"RTT109","ortholog_annotations":[{"gene_uniquename":"YLL002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01204","reference_uniquename":"PMID:29761456"}],"product":"Histone acetyltransferase; critical for cell survival in presence of DNA damage during S phase, required for recovery after DSB repair; acetylates H3K56, H3K9; H3K56 acetylation activity required for expression homeostasis, buffering of mRNA synthesis rate against changes in gene dosage during S phase; involved in non-homologous end joining and regulation of Ty1 transposition; prevents hyper-amplification of rDNA; interacts physically with Vps75p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003925","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL002W"}


id: YLL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03544":null,"YLL003W":null},"has_protein_features":false,"name":"SFI1","ortholog_annotations":[{"gene_uniquename":"YLL003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03544","reference_uniquename":"PMID:29761456"}],"product":"Centrin (Cdc31p)-binding protein required for SPB duplication; localizes to the half-bridge of the spindle pole body (SPB); required for progression through G(2)-M transition; phosphorylated by Cdc28p-Clb2p and by Cdc5p; dephosphorylated by Cdc14p; has similarity to Xenopus laevis XCAP-C","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003926","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL003W"}


id: YLL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05301":null,"YLL004W":null},"has_protein_features":false,"name":"ORC3","ortholog_annotations":[{"gene_uniquename":"YLL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05301","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003927","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL004W"}


id: YLL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPO75","product":"Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis","secondary_identifier":"SGD:S000003928","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL005C"}


id: YLL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04370":null,"YLL006W":null},"has_protein_features":false,"name":"MMM1","ortholog_annotations":[{"gene_uniquename":"YLL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04370","reference_uniquename":"PMID:29761456"}],"product":"ER integral membrane protein, ERMES complex subunit; ERMES links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase; localizes to the peroxisome in glucose","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003929","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL006W"}


id: YLL006W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028560","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL006W-A"}


id: YLL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LMO1","product":"Homolog of mammalian ELMO (Engulfment and celL MOtility); upstream component for regulation through the small GTPase Rho5p; may form a complex with Dck1p that acts as a GEF for Rho5p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein","secondary_identifier":"SGD:S000003930","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL007C"}


id: YLL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03730":null,"YLL008W":null},"has_protein_features":false,"name":"DRS1","ortholog_annotations":[{"gene_uniquename":"YLL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03730","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar DEAD-box protein required for ribosome assembly and function; including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003931","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL008W"}


id: YLL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00449":null,"YLL009C":null},"has_protein_features":false,"name":"COX17","ortholog_annotations":[{"gene_uniquename":"YLL009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00449","reference_uniquename":"PMID:29761456"}],"product":"Copper metallochaperone that transfers copper to Sco1p and Cox11p; eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs; interacts with the MICOS complex, and interaction is promoted by copper ions; human homolog COX17 partially complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003932","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL009C"}


id: YLL010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02389":null,"SJAG_04128":null,"YLL010C":null},"has_protein_features":false,"name":"PSR1","ortholog_annotations":[{"gene_uniquename":"YLL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02389","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04128","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane-associated protein phosphatase; involved in the general stress response and the inactivating dephosphorylation of Mep2p; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through Msn2p dephosphorylation, and for inhibition of TORC1 in response to limiting amino acids; regulates the sodium ion stress response with Psr2p; member of the HAD family of protein phosphatases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003933","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL010C"}


id: YLL011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03569":null,"YLL011W":null},"has_protein_features":false,"name":"SOF1","ortholog_annotations":[{"gene_uniquename":"YLL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03569","reference_uniquename":"PMID:29761456"}],"product":"Protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003934","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL011W"}


id: YLL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YEH1","product":"Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes; YEH1 has a paralog, YEH2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003935","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL012W"}


id: YLL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00686":null,"SJAG_00759":null,"SJAG_02036":null,"YLL013C":null},"has_protein_features":false,"name":"PUF3","ortholog_annotations":[{"gene_uniquename":"YLL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00686","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00759","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02036","reference_uniquename":"PMID:29761456"}],"product":"Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochondria during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins; translationally represses oxidative stress-linked genes; regulates CoQ biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003936","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL013C"}


id: YLL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04294":null,"YLL014W":null},"has_protein_features":false,"name":"EMC6","ortholog_annotations":[{"gene_uniquename":"YLL014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04294","reference_uniquename":"PMID:29761456"}],"product":"Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003937","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL014W"}


id: YLL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01344":null,"SJAG_03785":null,"SJAG_05213":null,"YLL015W":null},"has_protein_features":false,"name":"BPT1","ortholog_annotations":[{"gene_uniquename":"YLL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01344","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03785","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05213","reference_uniquename":"PMID:29761456"}],"product":"ABC type transmembrane transporter of MRP/CFTR family; found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003938","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL015W"}


id: YLL018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01197":null,"YLL018C":null},"has_protein_features":false,"name":"DPS1","ortholog_annotations":[{"gene_uniquename":"YLL018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01197","reference_uniquename":"PMID:29761456"}],"product":"Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation; shares five highly conserved amino acids with human that when mutated cause leukoencephalopathy characterized by hypomyelination with brain stem and spinal cord involvement and leg spasticity (HBSL)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003941","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL018C"}


id: YLL018C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01996":null,"YLL018C-A":null},"has_protein_features":false,"name":"COX19","ortholog_annotations":[{"gene_uniquename":"YLL018C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01996","reference_uniquename":"PMID:29761456"}],"product":"Protein required for cytochrome c oxidase assembly; located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL018C-A"}


id: YLL019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00996":null,"YLL019C":null},"has_protein_features":false,"name":"KNS1","ortholog_annotations":[{"gene_uniquename":"YLL019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00996","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003942","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL019C"}


id: YLL019W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene KNS1","secondary_identifier":"SGD:S000028670","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL019W-A"}


id: YLL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1","secondary_identifier":"SGD:S000003943","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL020C"}


id: YLL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03625":null,"YLL021W":null},"has_protein_features":false,"name":"SPA2","ortholog_annotations":[{"gene_uniquename":"YLL021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03625","reference_uniquename":"PMID:29761456"}],"product":"Component of the polarisome; functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate; coding sequence contains length polymorphisms in different strains; SPA2 has a paralog, SPH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003944","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL021W"}


id: YLL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04547":null,"YLL022C":null},"has_protein_features":false,"name":"HIF1","ortholog_annotations":[{"gene_uniquename":"YLL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04547","reference_uniquename":"PMID:29761456"}],"product":"Non-essential component of the HAT-B histone acetyltransferase complex; localized to the nucleus; has a role in telomeric silencing; other members are Hat1p and Hat2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003945","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL022C"}


id: YLL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01460":null,"YLL023C":null},"has_protein_features":false,"name":"POM33","ortholog_annotations":[{"gene_uniquename":"YLL023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01460","reference_uniquename":"PMID:29761456"}],"product":"Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003946","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL023C"}


id: YLL024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01186":null,"SJAG_04055":null,"YLL024C":null},"has_protein_features":false,"name":"SSA2","ortholog_annotations":[{"gene_uniquename":"YLL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01186","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04055","reference_uniquename":"PMID:29761456"}],"product":"HSP70 family ATP-binding protein; role in protein folding and vacuolar protein import; required for Ub-dependent degradation of short-lived proteins; associated with the chaperonin-containing T-complex; unique specificity in propagation of [URE3] prions and vacuolar degradation of gluconeogenic enzymes; contributes to tRNA nuclear import during starvation; targeted to vacuoles via the AP-3 pathway; localizes to exosomes during heat stress with a role in thermotolerance; 98% identity with Ssa1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003947","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL024C"}


id: YLL025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU17","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; YLL025W is not an essential gene","secondary_identifier":"SGD:S000003948","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL025W"}


id: YLL026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04187":null,"YLL026W":null},"has_protein_features":false,"name":"HSP104","ortholog_annotations":[{"gene_uniquename":"YLL026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04187","reference_uniquename":"PMID:29761456"}],"product":"Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate denatured, protein aggregates; responds to stresses (heat, ethanol, and sodium arsenite); required for the protein aggregate solid-to-liquid phase transition and dispersal of liquid condensates; involved in [PSI+] propagation; potentiated variants eliminate TDP-43 cytoplasmic aggregates to reduce proteotoxicity; becomes more abundant and forms cytoplasmic foci during replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003949","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL026W"}


id: YLL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03701":null,"YLL027W":null},"has_protein_features":false,"name":"ISA1","ortholog_annotations":[{"gene_uniquename":"YLL027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03701","reference_uniquename":"PMID:29761456"}],"product":"Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins; human ISCA1 can complement isa1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003950","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL027W"}


id: YLL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02059":null,"SJAG_02060":null,"YLL028W":null},"has_protein_features":false,"name":"TPO1","ortholog_annotations":[{"gene_uniquename":"YLL028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02059","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02060","reference_uniquename":"PMID:29761456"}],"product":"Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003951","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL028W"}


id: YLL029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00969":null,"YLL029W":null},"has_protein_features":false,"name":"FRA1","ortholog_annotations":[{"gene_uniquename":"YLL029W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00969","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003952","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL029W"}


id: YLL030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRT7","product":"Putative protein of unknown function; conserved across S. cerevisiae strains; identified in a screen for mutants with increased levels of rDNA transcription","secondary_identifier":"SGD:S000003953","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL030C"}


id: YLL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03506":null,"YLL031C":null},"has_protein_features":false,"name":"GPI13","ortholog_annotations":[{"gene_uniquename":"YLL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03506","reference_uniquename":"PMID:29761456"}],"product":"ER membrane localized phosphoryltransferase; adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003954","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL031C"}


id: YLL032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04521":null,"YLL032C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLL032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04521","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003955","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL032C"}


id: YLL033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC19","product":"Protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci","secondary_identifier":"SGD:S000003956","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL033W"}


id: YLL034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04599":null,"YLL034C":null},"has_protein_features":false,"name":"RIX7","ortholog_annotations":[{"gene_uniquename":"YLL034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04599","reference_uniquename":"PMID:29761456"}],"product":"Putative ATPase of the AAA family; required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003957","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL034C"}


id: YLL035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03789":null,"YLL035W":null},"has_protein_features":false,"name":"GRC3","ortholog_annotations":[{"gene_uniquename":"YLL035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03789","reference_uniquename":"PMID:29761456"}],"product":"Polynucleotide kinase present on rDNA; required for efficient transcription termination by RNA polymerase I; functions with Las1p in a conserved mechanism to cleave pre-rRNA at a specific site during rRNA processing and ribosome biogenesis; required for cell growth; mRNA is cell-cycle regulated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003958","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL035W"}


id: YLL036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04783":null,"YLL036C":null},"has_protein_features":false,"name":"PRP19","ortholog_annotations":[{"gene_uniquename":"YLL036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04783","reference_uniquename":"PMID:29761456"}],"product":"Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003959","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL036C"}


id: YLL037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor","secondary_identifier":"SGD:S000003960","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL037W"}


id: YLL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04644":null,"YLL038C":null},"has_protein_features":false,"name":"ENT4","ortholog_annotations":[{"gene_uniquename":"YLL038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04644","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003961","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL038C"}


id: YLL039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00452":null,"YLL039C":null},"has_protein_features":false,"name":"UBI4","ortholog_annotations":[{"gene_uniquename":"YLL039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00452","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via ubiquitin-26S proteasome system; essential for cellular stress response; encoded as polyubiquitin precursor comprised of 5 head-to-tail repeats; number of repeats is evolutionarily unstable within and between yeast species; protein abundance increases in response to DNA replication stress; implicated as modulator of replicative lifespan and meiotic recombination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003962","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL039C"}


id: YLL040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01229":null,"SJAG_16459":null,"YLL040C":null},"has_protein_features":false,"name":"VPS13","ortholog_annotations":[{"gene_uniquename":"YLL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01229","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL040C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16459","reference_uniquename":"PMID:29761456"}],"product":"Lipid transport protein; involved in vacuolar protein sorting, protein retention in the Golgi, prospore membrane formation and sporulation; required for mitochondrial integrity and ER packaging into autophagosomes during cortical reticulophagy; peripheral membrane protein found at the prospore membrane and at membrane contact sites; contains a PH-like domain; homologous to human CHAC and COH1, involved in Chorea-acanthocytosis and Cohen syndrome, respectively","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003963","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL040C"}


id: YLL041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00260":null,"YLL041C":null},"has_protein_features":false,"name":"SDH2","ortholog_annotations":[{"gene_uniquename":"YLL041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00260","reference_uniquename":"PMID:29761456"}],"product":"Iron-sulfur protein subunit of succinate dehydrogenase; the complex couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; other members are Sdh1p, Sdh3p, and Sdh4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003964","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL041C"}


id: YLL042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01251":null,"YLL042C":null},"has_protein_features":false,"name":"ATG10","ortholog_annotations":[{"gene_uniquename":"YLL042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01251","reference_uniquename":"PMID:29761456"}],"product":"Conserved E2-like conjugating enzyme; mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003965","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL042C"}


id: YLL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FPS1","product":"Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in transport of acetate, arsenite, and antimonite; key factor in maintaining redox balance by mediating passive diffusion of glycerol; phosphorylated by Hog1p and Slt2p MAPK; deletion improves xylose fermentation; regulated by Rgc1p and Ask10p, which are regulated by Hog1p phosphorylation under osmotic stress; phosphorylation by Ypk1p required to maintain an open state","secondary_identifier":"SGD:S000003966","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL043W"}


id: YLL044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant","secondary_identifier":"SGD:S000003967","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL044W"}


id: YLL045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00537":null,"YLL045C":null},"has_protein_features":false,"name":"RPL8B","ortholog_annotations":[{"gene_uniquename":"YLL045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00537","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB during assembly of large subunit; binds Domain I of 25S, 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; RPL8B has paralog RPL8A from whole genome duplication; RPL8A or RPL8B ribosomes not functionally interchangeable; proportions of Rpl8ap, Rpl8bp in 80S ribosome differ in glucose and glycerol; homologous to mammalian ribosomal protein L7A, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003968","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL045C"}


id: YLL046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04863":null,"YLL046C":null},"has_protein_features":false,"name":"RNP1","ortholog_annotations":[{"gene_uniquename":"YLL046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04863","reference_uniquename":"PMID:29761456"}],"product":"Ribonucleoprotein that contains two RNA recognition motifs (RRM); RNP1 has a paralog, SBP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003969","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL046C"}


id: YLL047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1","secondary_identifier":"SGD:S000003970","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL047W"}


id: YLL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01344":null,"SJAG_03785":null,"SJAG_05213":null,"YLL048C":null},"has_protein_features":false,"name":"YBT1","ortholog_annotations":[{"gene_uniquename":"YLL048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01344","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03785","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLL048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05213","reference_uniquename":"PMID:29761456"}],"product":"Transporter of ATP-binding cassette (ABC) family; targeted to vacuole via AP-3 pathway; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003971","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL048C"}


id: YLL049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LDB18","product":"Component of the dynactin complex; dynactin is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24","secondary_identifier":"SGD:S000003972","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL049W"}


id: YLL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03025":null,"YLL050C":null},"has_protein_features":false,"name":"COF1","ortholog_annotations":[{"gene_uniquename":"YLL050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03025","reference_uniquename":"PMID:29761456"}],"product":"Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003973","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL050C"}


id: YLL051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04743":null,"YLL051C":null},"has_protein_features":false,"name":"FRE6","ortholog_annotations":[{"gene_uniquename":"YLL051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003974","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL051C"}


id: YLL052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AQY2","product":"Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains","secondary_identifier":"SGD:S000003975","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL052C"}


id: YLL053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin","secondary_identifier":"SGD:S000003976","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL053C"}


id: YLL054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function with similarity to Pip2p; an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene","secondary_identifier":"SGD:S000003977","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL054C"}


id: YLL055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04295":null,"YLL055W":null},"has_protein_features":false,"name":"YCT1","ortholog_annotations":[{"gene_uniquename":"YLL055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04295","reference_uniquename":"PMID:29761456"}],"product":"High-affinity cysteine-specific transporter; has similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003978","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL055W"}


id: YLL056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"NADH-dependent aldehyde reductase; reduces many aldehyde compounds including glycolaldehyde, formaldehyde and furfural; transcription unregulated by furfural, 5-hydroxymethylfurfural (HMF) and the mycotoxin patulin; expression increased by multidrug resistance transcription factors Yrm1p and Yrr1p; member of atypical subgroup 7 of the short-chain dehydrogenase/reductase (SDR) family; localizes to the cytoplasm; SWAT-GFP and mCherry fusion proteins localize to the ER and vacuole respectively","secondary_identifier":"SGD:S000003979","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL056C"}


id: YLL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"JLP1","product":"Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation","secondary_identifier":"SGD:S000003980","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL057C"}


id: YLL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03102":null,"YLL058W":null},"has_protein_features":false,"name":"HSU1","ortholog_annotations":[{"gene_uniquename":"YLL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03102","reference_uniquename":"PMID:29761456"}],"product":"Inefficient homocysteine synthase; catalyzes de novo homocysteine biosynthesis; capable of catalyzing same reaction as Met17p; affects S-methylmethionine metabolism; similar to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; HSU1 is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003981","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL058W"}


id: YLL059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003982","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL059C"}


id: YLL060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GTT2","product":"Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003983","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL060C"}


id: YLL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MMP1","product":"High-affinity S-methylmethionine permease; required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p","secondary_identifier":"SGD:S000003984","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL061W"}


id: YLL062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04425":null,"YLL062C":null},"has_protein_features":false,"name":"MHT1","ortholog_annotations":[{"gene_uniquename":"YLL062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04425","reference_uniquename":"PMID:29761456"}],"product":"S-methylmethionine-homocysteine methyltransferase; functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003985","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL062C"}


id: YLL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00020":null,"SJAG_00021":null,"SJAG_00075":null,"SJAG_01363":null,"SJAG_02126":null,"SJAG_02127":null,"SJAG_02940":null,"YLL063C":null},"has_protein_features":false,"name":"AYT1","ortholog_annotations":[{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00020","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00021","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00075","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01363","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02126","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02127","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02940","reference_uniquename":"PMID:26896847"}],"product":"Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis; localized to peroxisomes","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000003986","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL063C"}


id: YLL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU18","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau6p","secondary_identifier":"SGD:S000003987","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL064C"}


id: YLL065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps chromosome XII telomeric element core sequences","secondary_identifier":"SGD:S000003988","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL065W"}


id: YLL066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative Y' element ATP-dependent helicase; YLL066C is not an essential gene","secondary_identifier":"SGD:S000003989","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL066C"}


id: YLL066W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YLL066C","secondary_identifier":"SGD:S000028671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL066W-A"}


id: YLL066W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; overexpression causes a cell cycle delay or arrest","secondary_identifier":"SGD:S000028672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL066W-B"}


id: YLL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative Y' element ATP-dependent helicase","secondary_identifier":"SGD:S000003990","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL067C"}


id: YLL067W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps YLL067C","secondary_identifier":"SGD:S000028673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLL067W-A"}


id: YLR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00732":null,"YLR001C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00732","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003991","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR001C"}


id: YLR002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00311":null,"YLR002C":null},"has_protein_features":false,"name":"NOC3","ortholog_annotations":[{"gene_uniquename":"YLR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00311","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003992","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR002C"}


id: YLR003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01115":null,"YLR003C":null},"has_protein_features":false,"name":"CMS1","ortholog_annotations":[{"gene_uniquename":"YLR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01115","reference_uniquename":"PMID:29761456"}],"product":"Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003993","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR003C"}


id: YLR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02139":null,"SJAG_05182":null,"YLR004C":null},"has_protein_features":false,"name":"THI73","ortholog_annotations":[{"gene_uniquename":"YLR004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02139","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR004C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05182","reference_uniquename":"PMID:29761456"}],"product":"Putative plasma membrane permease; proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003994","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR004C"}


id: YLR005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00758":null,"YLR005W":null},"has_protein_features":false,"name":"SSL1","ortholog_annotations":[{"gene_uniquename":"YLR005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00758","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the core form of RNA polymerase transcription factor TFIIH; has both protein kinase and DNA-dependent ATPase/helicase activities; essential for transcription and nucleotide excision repair; interacts with Tfb4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003995","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR005W"}


id: YLR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00318":null,"YLR006C":null},"has_protein_features":false,"name":"SSK1","ortholog_annotations":[{"gene_uniquename":"YLR006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00318","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic phosphorelay intermediate osmosensor and regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003996","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR006C"}


id: YLR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05323":null,"YLR007W":null},"has_protein_features":false,"name":"NSE1","ortholog_annotations":[{"gene_uniquename":"YLR007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05323","reference_uniquename":"PMID:29761456"}],"product":"Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003997","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR007W"}


id: YLR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01597":null,"YLR008C":null},"has_protein_features":false,"name":"PAM18","ortholog_annotations":[{"gene_uniquename":"YLR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01597","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the import motor (PAM complex); the PAM complex is a  component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003998","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR008C"}


id: YLR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04395":null,"YLR009W":null},"has_protein_features":false,"name":"RLP24","ortholog_annotations":[{"gene_uniquename":"YLR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04395","reference_uniquename":"PMID:29761456"}],"product":"Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003999","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR009W"}


id: YLR010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04245":null,"YLR010C":null},"has_protein_features":false,"name":"TEN1","ortholog_annotations":[{"gene_uniquename":"YLR010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04245","reference_uniquename":"PMID:29761456"}],"product":"Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p; similar to human Ten1 which is critical for the telomeric function of the CST (Cdc13p-Stn1p-Ten1p) complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004000","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR010C"}


id: YLR011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LOT6","product":"FMN-dependent NAD(P)H:quinone reductase; role in apoptosis-like cell death; may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions","secondary_identifier":"SGD:S000004001","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR011W"}


id: YLR012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YLR012C is not an essential gene","secondary_identifier":"SGD:S000004002","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR012C"}


id: YLR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GAT3","product":"Protein containing GATA family zinc finger motifs; involved in spore wall assembly; sequence similarity to GAT4, and the double mutant gat3 gat4 exhibits reduced dityrosine fluorescence relative to the single mutants","secondary_identifier":"SGD:S000004003","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR013W"}


id: YLR014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PPR1","product":"Zinc finger transcription factor; contains a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p","secondary_identifier":"SGD:S000004004","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR014C"}


id: YLR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00896":null,"YLR015W":null},"has_protein_features":false,"name":"BRE2","ortholog_annotations":[{"gene_uniquename":"YLR015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00896","reference_uniquename":"PMID:29761456"}],"product":"Subunit of COMPASS (Set1C) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004005","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR015W"}


id: YLR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PML1","product":"Subunit of the RES complex; RES complex is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p","secondary_identifier":"SGD:S000004006","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR016C"}


id: YLR017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03881":null,"YLR017W":null},"has_protein_features":false,"name":"MEU1","ortholog_annotations":[{"gene_uniquename":"YLR017W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03881","reference_uniquename":"PMID:29761456"}],"product":"Methylthioadenosine phosphorylase (MTAP); catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004007","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR017W"}


id: YLR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03281":null,"YLR018C":null},"has_protein_features":false,"name":"POM34","ortholog_annotations":[{"gene_uniquename":"YLR018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03281","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004008","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR018C"}


id: YLR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02389":null,"SJAG_04128":null,"YLR019W":null},"has_protein_features":false,"name":"PSR2","ortholog_annotations":[{"gene_uniquename":"YLR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02389","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04128","reference_uniquename":"PMID:29761456"}],"product":"Putative plasma membrane phosphatase; involved in the general stress response and inactivating dephosphorylation of Mep2p; required along with Psr1p and binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through Msn2p dephosphorylation, and for inhibition of TORC1 in response to limiting amino acids; regulates the sodium ion stress response with Psr1p; member of the HAD family of protein phosphatases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004009","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR019W"}


id: YLR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YEH2","product":"Steryl ester hydrolase; catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; YEH2 has a paralog, YEH1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004010","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR020C"}


id: YLR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04602":null,"YLR021W":null},"has_protein_features":false,"name":"IRC25","ortholog_annotations":[{"gene_uniquename":"YLR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04602","reference_uniquename":"PMID:29761456"}],"product":"Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004011","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR021W"}


id: YLR022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04491":null,"YLR022C":null},"has_protein_features":false,"name":"SDO1","ortholog_annotations":[{"gene_uniquename":"YLR022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04491","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor (GEF) for Ria1p; essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004012","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR022C"}


id: YLR023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02080":null,"YLR023C":null},"has_protein_features":false,"name":"IZH3","ortholog_annotations":[{"gene_uniquename":"YLR023C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02080","reference_uniquename":"PMID:29761456"}],"product":"Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004013","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR023C"}


id: YLR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01253":null,"SJAG_04619":null,"YLR024C":null},"has_protein_features":false,"name":"UBR2","ortholog_annotations":[{"gene_uniquename":"YLR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01253","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04619","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic ubiquitin-protein ligase (E3); component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex required for the ubiquitination and degradation of Rpn4p; mediates formation of the ternary complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004014","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR024C"}


id: YLR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01242":null,"YLR025W":null},"has_protein_features":false,"name":"SNF7","ortholog_annotations":[{"gene_uniquename":"YLR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01242","reference_uniquename":"PMID:29761456"}],"product":"One of four core subunits of the ESCRT-III complex; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes; subunit of the endosomal sorting complex required for transport III (ESCRT-III) that forms flat spirals on lipid monolayers as part of the complexes role in driving membrane abscission","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004015","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR025W"}


id: YLR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03552":null,"YLR026C":null},"has_protein_features":false,"name":"SED5","ortholog_annotations":[{"gene_uniquename":"YLR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03552","reference_uniquename":"PMID:29761456"}],"product":"cis-Golgi t-SNARE syntaxin; required for vesicular transport between the ER and the Golgi complex; binds at least 9 SNARE proteins; plays a role in autophagy by regulating formation of autophagic vesicles in Golgi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004016","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR026C"}


id: YLR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03306":null,"YLR027C":null},"has_protein_features":false,"name":"AAT2","ortholog_annotations":[{"gene_uniquename":"YLR027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03306","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic aspartate aminotransferase involved in the metabolism of nitrogen and amino acids such as aspartate; localizes to and functions in peroxisomes in oleate-grown cells; moonlighting role as a ribosome-associated protein that modulates translation in response to stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004017","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR027C"}


id: YLR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04681":null,"YLR028C":null},"has_protein_features":false,"name":"ADE16","ortholog_annotations":[{"gene_uniquename":"YLR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04681","reference_uniquename":"PMID:29761456"}],"product":"Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004018","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR028C"}


id: YLR029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03919":null,"SJAG_04478":null,"YLR029C":null},"has_protein_features":false,"name":"RPL15A","ortholog_annotations":[{"gene_uniquename":"YLR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03919","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04478","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004019","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR029C"}


id: YLR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W","secondary_identifier":"SGD:S000004020","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR030W"}


id: YLR031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W; YLR031W has a paralog, YMR124W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004021","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR031W"}


id: YLR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02521":null,"YLR032W":null},"has_protein_features":false,"name":"RAD5","ortholog_annotations":[{"gene_uniquename":"YLR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02521","reference_uniquename":"PMID:29761456"}],"product":"DNA helicase/Ubiquitin ligase; involved in error-free DNA damage tolerance (DDT), replication fork regression during postreplication repair by template switching, and error-prone translesion synthesis; required for UV and MMS-associated unequal sister chromatid exchange (SCE) but not for double-strand break associated unequal SCE; promotes synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; human homolog HLTF can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004022","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR032W"}


id: YLR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03758":null,"YLR033W":null},"has_protein_features":false,"name":"RSC58","ortholog_annotations":[{"gene_uniquename":"YLR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03758","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004023","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR033W"}


id: YLR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01007":null,"YLR034C":null},"has_protein_features":false,"name":"SMF3","ortholog_annotations":[{"gene_uniquename":"YLR034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01007","reference_uniquename":"PMID:29761456"}],"product":"Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of Nramp family of metal transport proteins; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004024","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR034C"}


id: YLR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MLH2","product":"Protein involved in mismatch repair and meiotic recombination; only certain frameshift intermediates are mismatch repair substrates; forms a complex with Mlh1p, plays accessory role in stimulating activity of MLH1/PMS1 complex","secondary_identifier":"SGD:S000004025","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR035C"}


id: YLR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein","secondary_identifier":"SGD:S000004026","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR036C"}


id: YLR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU23","product":"Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth","secondary_identifier":"SGD:S000004027","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR037C"}


id: YLR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02504":null,"YLR038C":null},"has_protein_features":false,"name":"COX12","ortholog_annotations":[{"gene_uniquename":"YLR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02504","reference_uniquename":"PMID:29761456"}],"product":"Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly and activity of cytochrome c oxidase; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004028","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR038C"}


id: YLR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00143":null,"YLR039C":null},"has_protein_features":false,"name":"RIC1","ortholog_annotations":[{"gene_uniquename":"YLR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00143","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004029","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR039C"}


id: YLR040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AFB1","product":"MATalpha-specific a-factor blocker; contributes to mating efficiency under certain conditions; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W","secondary_identifier":"SGD:S000004030","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR040C"}


id: YLR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C","secondary_identifier":"SGD:S000004031","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR041W"}


id: YLR042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NFG1","product":"Negative regulator of the filamentous growth pathway; inhibits invasive growth by dampening the activity of the filamentous MAPK pathway; localizes to the cell wall and to the vacuole and cell periphery in HTP studies; deletion improves xylose fermentation in industrially engineered strains; nonessential gene","secondary_identifier":"SGD:S000004032","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR042C"}


id: YLR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04953":null,"YLR043C":null},"has_protein_features":false,"name":"TRX1","ortholog_annotations":[{"gene_uniquename":"YLR043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04953","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system that protects cells from oxidative and reductive stress; subunit of the LMA1 complex, with Pbi2p, that promotes vacuole inheritance; cofactor for Tsa1p; required for ER-Golgi transport; facilitates mitochondrial import of small Tims (Tim9p, Tim10p, Tim13p) by maintaining them in reduced form along with Trx2p; component of a signal transduction redox relay in a light sensing pathway; abundance increases under DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004033","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR043C"}


id: YLR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02734":null,"SJAG_03743":null,"SJAG_04842":null,"YLR044C":null},"has_protein_features":false,"name":"PDC1","ortholog_annotations":[{"gene_uniquename":"YLR044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02734","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03743","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04842","reference_uniquename":"PMID:29761456"}],"product":"Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo; protein tyrosine nitration on Tyr157 or Tyr344 inhibits activity and impairs fermentation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004034","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR044C"}


id: YLR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02624":null,"SJAG_03540":null,"YLR045C":null},"has_protein_features":false,"name":"STU2","ortholog_annotations":[{"gene_uniquename":"YLR045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02624","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03540","reference_uniquename":"PMID:29761456"}],"product":"Microtubule polymerase of the XMAP215/Dis1 family; required for elongation of mitotic spindle during anaphase, as well as for spindle orientation and metaphase chromosome alignment; stabilizes or destabilizes kinetochore-microtubule attachment depending on kinetochore tension; interacts with spindle pole body component Spc72p; metazoan ch-TOG/XMAP215 family member","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004035","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR045C"}


id: YLR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00018":null,"SJAG_00587":null,"SJAG_00589":null,"SJAG_01095":null,"SJAG_02114":null,"SJAG_02132":null,"SJAG_02581":null,"SJAG_02943":null,"SJAG_02957":null,"YLR046C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00018","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00587","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00589","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01095","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02114","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02132","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02581","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02943","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02957","reference_uniquename":"PMID:29761456"}],"product":"Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YLR046C has a paralog, RTA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004036","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR046C"}


id: YLR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04743":null,"YLR047C":null},"has_protein_features":false,"name":"FRE8","ortholog_annotations":[{"gene_uniquename":"YLR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Protein with sequence similarity to iron/copper reductases; involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004037","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR047C"}


id: YLR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02184":null,"SJAG_02479":null,"SJAG_02803":null,"YLR048W":null},"has_protein_features":false,"name":"RPS0B","ortholog_annotations":[{"gene_uniquename":"YLR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02184","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02479","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02803","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004038","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR048W"}


id: YLR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MLO50","product":"Mitochondrial protein of unknown function","secondary_identifier":"SGD:S000004039","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR049C"}


id: YLR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07010":null,"YLR050C":null},"has_protein_features":false,"name":"EMA19","ortholog_annotations":[{"gene_uniquename":"YLR050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07010","reference_uniquename":"PMID:29761456"}],"product":"Integral ER membrane protein involved in protein sorting; component of ER-SURF, a pathway involved in retrieving mitochondrial membrane protein precursors and rerouting them to the mitochondrial translocation system; promotes the proteolytic degradation of non-productive mitochondrial precursor proteins suggesting involvement in quality control during protein import; GFP-fusion protein localizes to the ER; member of a conserved family of ER proteins including human homolog TMEM97","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004040","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR050C"}


id: YLR051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04838":null,"YLR051C":null},"has_protein_features":false,"name":"FCF2","ortholog_annotations":[{"gene_uniquename":"YLR051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04838","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon; essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004041","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR051C"}


id: YLR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IES3","product":"Subunit of the INO80 chromatin remodeling complex","secondary_identifier":"SGD:S000004042","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR052W"}


id: YLR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NRS1","product":"Nitrogen-responsive activator of Start; nuclear microprotein with transcriptional activator activity; bypasses Start arrest in a cln3 bck2 double mutant when overexpressed; interacts with subunits of the SBF complex (Swi4p-Swi6p); induced by nitrogen limitation and rapamycin with peak abundance at Start; proposed to promote the G1/S transition by rewiring the G1/S transcriptional machinery under poor nitrogen conditions upstream of the Whi5-inhibited form of SBF and independent of Cln3 and Bck2","secondary_identifier":"SGD:S000004043","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR053C"}


id: YLR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OSW2","product":"Protein of unknown function reputedly involved in spore wall assembly","secondary_identifier":"SGD:S000004044","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR054C"}


id: YLR055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02066":null,"YLR055C":null},"has_protein_features":false,"name":"SPT8","ortholog_annotations":[{"gene_uniquename":"YLR055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02066","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SAGA transcriptional regulatory complex; not present in SAGA-like complex SLIK/SALSA; required for SAGA-mediated inhibition at some promoters","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004045","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR055C"}


id: YLR056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00717":null,"SJAG_03509":null,"YLR056W":null},"has_protein_features":false,"name":"ERG3","ortholog_annotations":[{"gene_uniquename":"YLR056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00717","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03509","reference_uniquename":"PMID:29761456"}],"product":"C-5 sterol desaturase; glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of HRD ubiquitin ligase; mutation is functionally complemented by human SC5D","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004046","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR056W"}


id: YLR057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MNL2","product":"Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene","secondary_identifier":"SGD:S000004047","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR057W"}


id: YLR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01766":null,"YLR058C":null},"has_protein_features":false,"name":"SHM2","ortholog_annotations":[{"gene_uniquename":"YLR058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01766","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004048","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR058C"}


id: YLR059C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00401":null,"YLR059C":null},"has_protein_features":false,"name":"REX2","ortholog_annotations":[{"gene_uniquename":"YLR059C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00401","reference_uniquename":"PMID:29761456"}],"product":"3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease; role in preventing L-A mycovirus pathogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004049","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR059C"}


id: YLR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02206":null,"YLR060W":null},"has_protein_features":false,"name":"FRS1","ortholog_annotations":[{"gene_uniquename":"YLR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02206","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004050","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR060W"}


id: YLR061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00220":null,"YLR061W":null},"has_protein_features":false,"name":"RPL22A","ortholog_annotations":[{"gene_uniquename":"YLR061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00220","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L22A; required for translation of long 5' UTR of IME1 mRNA and meiotic entry; required for the oxidative stress response, pseudohyphal and invasive growth; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004051","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR061W"}


id: YLR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUD28","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay","secondary_identifier":"SGD:S000004052","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR062C"}


id: YLR063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BMT6","product":"Methyltransferase required for m3U2843 methylation of the 25S rRNA; S-adenosylmethionine-dependent; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene","secondary_identifier":"SGD:S000004053","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR063W"}


id: YLR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01460":null,"YLR064W":null},"has_protein_features":false,"name":"PER33","ortholog_annotations":[{"gene_uniquename":"YLR064W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01460","reference_uniquename":"PMID:29761456"}],"product":"Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004054","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR064W"}


id: YLR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03315":null,"YLR065C":null},"has_protein_features":false,"name":"SND2","ortholog_annotations":[{"gene_uniquename":"YLR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03315","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Pho88p/Snd3p and Sec61p-translocon subunits; can compensate for loss of SRP; role in the late endosome-vacuole interface; putative role in secretory protein quality control","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004055","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR065C"}


id: YLR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03737":null,"YLR066W":null},"has_protein_features":false,"name":"SPC3","ortholog_annotations":[{"gene_uniquename":"YLR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03737","reference_uniquename":"PMID:29761456"}],"product":"Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; other members of the complex are Spc1p, Spc2p, and Sec11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004056","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR066W"}


id: YLR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01249":null,"YLR067C":null},"has_protein_features":false,"name":"PET309","ortholog_annotations":[{"gene_uniquename":"YLR067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01249","reference_uniquename":"PMID:29761456"}],"product":"Specific translational activator for the COX1 mRNA; binds to the COX1 mRNA; also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains 12 pentatricopeptide repeats (PPRs)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004057","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR067C"}


id: YLR068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01250":null,"YLR068W":null},"has_protein_features":false,"name":"FYV7","ortholog_annotations":[{"gene_uniquename":"YLR068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01250","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004058","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR068W"}


id: YLR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02353":null,"YLR069C":null},"has_protein_features":false,"name":"MEF1","ortholog_annotations":[{"gene_uniquename":"YLR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02353","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial elongation factor involved in translational elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004059","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR069C"}


id: YLR070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00237":null,"YLR070C":null},"has_protein_features":false,"name":"XYL2","ortholog_annotations":[{"gene_uniquename":"YLR070C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00237","reference_uniquename":"PMID:29761456"}],"product":"Xylitol dehydrogenase; converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004060","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR070C"}


id: YLR071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03573":null,"YLR071C":null},"has_protein_features":false,"name":"RGR1","ortholog_annotations":[{"gene_uniquename":"YLR071C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03573","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004061","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR071C"}


id: YLR072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01329":null,"YLR072W":null},"has_protein_features":false,"name":"LAM6","ortholog_annotations":[{"gene_uniquename":"YLR072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01329","reference_uniquename":"PMID:29761456"}],"product":"Sterol transporter that transfers sterols between membranes; may regulate and coordinate formation of contact sites between organelles; localizes to ER-mitochondrial contact sites in a Tom70p- and Tom71p-dependent manner; mitochondrial localization requires GRAM domain; also localizes to ER-vacuole contact sites, in a Vac8p-dependent manner; has GRAM and StART-like (VASt) domains; one of six StART-like domain-containing proteins in yeast; conserved across eukaryotes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004062","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR072W"}


id: YLR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RFU1","product":"Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes","secondary_identifier":"SGD:S000004063","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR073C"}


id: YLR074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01280":null,"YLR074C":null},"has_protein_features":false,"name":"BUD20","ortholog_annotations":[{"gene_uniquename":"YLR074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01280","reference_uniquename":"PMID:29761456"}],"product":"C2H2-type zinc finger protein required for ribosome assembly; shuttling factor which associates with pre-60S particles in the nucleus, accompanying them to the cytoplasm; cytoplasmic dissociation of Bud20p requires Drg1p; N-terminus harbors a nuclear localization signal (NLS) and a nuclear export signal (NES); cytoplasmic Bud20p is reimported by Kap123-dependent pathway; involved in bud-site selection; diploid mutants display a random budding pattern; similar to human ZNF593","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004064","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR074C"}


id: YLR075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04176":null,"YLR075W":null},"has_protein_features":false,"name":"RPL10","ortholog_annotations":[{"gene_uniquename":"YLR075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04176","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L10; homologous to mammalian ribosomal protein L10 and bacterial L16; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; protein abundance increases under DNA replication stress; mutations in human homolog implicated in T-cell acute lymphoblastic leukemia and also autism spectrum disorders (ASD); human RPL10 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004065","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR075W"}


id: YLR076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10","secondary_identifier":"SGD:S000004066","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR076C"}


id: YLR077W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMP25","product":"Protein required for assembly of respiratory complex III; mitochondrial inner membrane protein; required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria","secondary_identifier":"SGD:S000004067","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR077W"}


id: YLR078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04513":null,"YLR078C":null},"has_protein_features":false,"name":"BOS1","ortholog_annotations":[{"gene_uniquename":"YLR078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04513","reference_uniquename":"PMID:29761456"}],"product":"v-SNARE (vesicle specific SNAP receptor); localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi; required for efficient nuclear fusion during mating","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004068","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR078C"}


id: YLR079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SIC1","product":"Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylated by Clb5/6-Cdk1 and Cln1/2-Cdk1 kinase which regulate timing of Sic1p degradation; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1","secondary_identifier":"SGD:S000004069","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR079W"}


id: YLR080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02839":null,"YLR080W":null},"has_protein_features":false,"name":"EMP46","ortholog_annotations":[{"gene_uniquename":"YLR080W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02839","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane component of ER-derived COPII-coated vesicles; functions in ER to Golgi transport; EMP46 has a paralog, EMP47, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004070","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR080W"}


id: YLR081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YLR081W":null},"has_protein_features":false,"name":"GAL2","ortholog_annotations":[{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YLR081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Galactose permease; required for utilization of galactose; also able to transport glucose","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004071","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR081W"}


id: YLR082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SRL2","product":"Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation","secondary_identifier":"SGD:S000004072","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR082C"}


id: YLR083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00299":null,"YLR083C":null},"has_protein_features":false,"name":"EMP70","ortholog_annotations":[{"gene_uniquename":"YLR083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00299","reference_uniquename":"PMID:29761456"}],"product":"Protein with a role in cellular adhesion and filamentous growth; also endosome-to-vacuole sorting; similar to Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; EMP70 has a paralog, TMN2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004073","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR083C"}


id: YLR084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01388":null,"YLR084C":null},"has_protein_features":false,"name":"RAX2","ortholog_annotations":[{"gene_uniquename":"YLR084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01388","reference_uniquename":"PMID:29761456"}],"product":"Protein required for the maintenance of bud site selection; localizes; localization to the bud neck and previous sites of cell division (bud scars; cytokinesis remnants (CRMs)) is interdependent with Rax2p; required with Rax1p to anchor both Nba1p and Nis1p to CRMs where a Cdc42p inhibitory zone is established preventing repolarization of cells at previous division sites; RAX2 mRNA stability is regulated by Mpt5p; predicted type I membrane-spanning protein; N-glycosylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004074","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR084C"}


id: YLR085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03694":null,"YLR085C":null},"has_protein_features":false,"name":"ARP6","ortholog_annotations":[{"gene_uniquename":"YLR085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03694","reference_uniquename":"PMID:29761456"}],"product":"Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004075","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR085C"}


id: YLR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00871":null,"YLR086W":null},"has_protein_features":false,"name":"SMC4","ortholog_annotations":[{"gene_uniquename":"YLR086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00871","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004076","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR086W"}


id: YLR087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSF1","product":"Protein with structural similarity to lipid transport protein Vps13p; localizes to multiple membrane contact sites between organelles; role in phospholipid homeostasis and lipidomic adaptation to cold; required for fermentation at low temperature; plays a role in phosphatidylethanolamine metabolism and secretory protein maturation; non-tagged protein is detected in highly purified mitochondria in HTP studies","secondary_identifier":"SGD:S000004077","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR087C"}


id: YLR088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03292":null,"YLR088W":null},"has_protein_features":false,"name":"GAA1","ortholog_annotations":[{"gene_uniquename":"YLR088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03292","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the GPI:protein transamidase complex; removes the GPI-anchoring signal and attaches GPI (glycosylphosphatidylinositol) to proteins in the ER; human homolog GPAA1 can complement growth defects of yeast thermosensitive mutant at restrictive temperature","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004078","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR088W"}


id: YLR089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04145":null,"YLR089C":null},"has_protein_features":false,"name":"ALT1","ortholog_annotations":[{"gene_uniquename":"YLR089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04145","reference_uniquename":"PMID:29761456"}],"product":"Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthesis and catabolism; TOR1-independent role in determining chronological lifespan; expression is induced in the presence of alanine; repression is mediated by Nrg1p; ALT1 has a paralog, ALT2, that arose from the whole genome duplication; Alt2p is catalytically inactive","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004079","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR089C"}


id: YLR090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03135":null,"YLR090W":null},"has_protein_features":false,"name":"XDJ1","ortholog_annotations":[{"gene_uniquename":"YLR090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03135","reference_uniquename":"PMID:29761456"}],"product":"Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004080","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR090W"}


id: YLR091W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GEP5","product":"Protein of unknown function; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine; localizes to the matrix side of the inner mitochondrial membrane","secondary_identifier":"SGD:S000004081","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR091W"}


id: YLR092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02463":null,"YLR092W":null},"has_protein_features":false,"name":"SUL2","ortholog_annotations":[{"gene_uniquename":"YLR092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02463","reference_uniquename":"PMID:29761456"}],"product":"High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004082","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR092W"}


id: YLR093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NYV1","product":"v-SNARE component of vacuolar SNARE complex; involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in vacuolar membrane; targeted to vacuole via AP-3 pathway","secondary_identifier":"SGD:S000004083","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR093C"}


id: YLR094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GIS3","product":"Protein of unknown function","secondary_identifier":"SGD:S000004084","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR094C"}


id: YLR095C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IOC2","product":"Subunit of the Isw1b complex; exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing; contains a PHD finger motif; other complex members are Isw1p and Ioc4p","secondary_identifier":"SGD:S000004085","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR095C"}


id: YLR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02838":null,"YLR096W":null},"has_protein_features":false,"name":"KIN2","ortholog_annotations":[{"gene_uniquename":"YLR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02838","reference_uniquename":"PMID:29761456"}],"product":"S/T protein kinase; regulates polarized exocytosis and the Ire1p-mediated UPR; regulates HAC1 mRNA translocation, splicing and translation with KIN1 during ER stress; direct phosphorylation of Sec9p (S190) is enhanced by prior substrate priming (S192); localizes to the cytoplasmic face of the PM and sites of polarized growth; may regulate septin and cell wall organization; activation loop phosphorylation (T281) required for full kinase activity; orthologous to MARK/PAR-1, AMPK family members","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004086","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR096W"}


id: YLR097C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03651":null,"YLR097C":null},"has_protein_features":false,"name":"HRT3","ortholog_annotations":[{"gene_uniquename":"YLR097C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03651","reference_uniquename":"PMID:29761456"}],"product":"Putative SCF-ubiquitin ligase F-box protein; based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004087","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR097C"}


id: YLR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05337":null,"YLR098C":null},"has_protein_features":false,"name":"CHA4","ortholog_annotations":[{"gene_uniquename":"YLR098C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05337","reference_uniquename":"PMID:29761456"}],"product":"DNA binding transcriptional activator; mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004088","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR098C"}


id: YLR099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ICT1","product":"Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication; human ABHD5 can complement ict1 null mutant","secondary_identifier":"SGD:S000004089","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR099C"}


id: YLR099W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02361":null,"YLR099W-A":null},"has_protein_features":false,"name":"MIM2","ortholog_annotations":[{"gene_uniquename":"YLR099W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02361","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for outer membrane protein import; involved in import of the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and Fzo1p; component of a large protein complex in the outer membrane that includes Mim1p and functions as cation-selective channel for translocation of positively charged precursor segments; not essential in W303 strain background","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007618","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR099W-A"}


id: YLR100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03235":null,"YLR100W":null},"has_protein_features":false,"name":"ERG27","ortholog_annotations":[{"gene_uniquename":"YLR100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03235","reference_uniquename":"PMID:29761456"}],"product":"3-keto sterol reductase; catalyzes last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; Erg27 protein is mainly ER-localized in strains devoid of mtDNA (rho° cells); mutants are sterol auxotrophs; mutation is functionally complemented by human HSD17B7","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004090","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR100W"}


id: YLR101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W","secondary_identifier":"SGD:S000004091","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR101C"}


id: YLR102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"APC9","product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition","secondary_identifier":"SGD:S000004092","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR102C"}


id: YLR103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00327":null,"YLR103C":null},"has_protein_features":false,"name":"CDC45","ortholog_annotations":[{"gene_uniquename":"YLR103C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00327","reference_uniquename":"PMID:29761456"}],"product":"DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004093","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR103C"}


id: YLR104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LCL2","product":"Putative protein of unknown function; mutant is deficient in cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD); SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole","secondary_identifier":"SGD:S000004094","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR104W"}


id: YLR105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03328":null,"YLR105C":null},"has_protein_features":false,"name":"SEN2","ortholog_annotations":[{"gene_uniquename":"YLR105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03328","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease; localizes to the peroxisome in a Pex5p-dependent manner in oleate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004095","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR105C"}


id: YLR106C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03496":null,"YLR106C":null},"has_protein_features":false,"name":"REA1","ortholog_annotations":[{"gene_uniquename":"YLR106C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03496","reference_uniquename":"PMID:29761456"}],"product":"Huge dynein-related AAA-type ATPase (midasin); forms extended pre-60S particle with the Rix1 complex; involved with interaction partners Rsa4p and Ytm1p, in the ATP-dependent remodeling of the pre-60S particle at successive maturation steps during ribosomal biogenesis; involved in the removal of biogenesis factors including GTPase Nog2p prior to nuclear export; contains a hexameric AAA-motor head domain and a long flexible tail with a MIDAS (metal ion-dependent adhesion site) domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004096","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR106C"}


id: YLR107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00081":null,"YLR107W":null},"has_protein_features":false,"name":"REX3","ortholog_annotations":[{"gene_uniquename":"YLR107W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00081","reference_uniquename":"PMID:29761456"}],"product":"RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004097","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR107W"}


id: YLR108C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004098","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR108C"}


id: YLR109W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03166":null,"YLR109W":null},"has_protein_features":false,"name":"AHP1","ortholog_annotations":[{"gene_uniquename":"YLR109W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03166","reference_uniquename":"PMID:29761456"}],"product":"Thiol-specific peroxiredoxin; reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004099","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR109W"}


id: YLR110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CCW12","product":"Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004100","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR110C"}


id: YLR111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000004101","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR111W"}


id: YLR112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000004102","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR112W"}


id: YLR113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02592":null,"YLR113W":null},"has_protein_features":false,"name":"HOG1","ortholog_annotations":[{"gene_uniquename":"YLR113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02592","reference_uniquename":"PMID:29761456"}],"product":"Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004103","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR113W"}


id: YLR114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02443":null,"YLR114C":null},"has_protein_features":false,"name":"AVL9","ortholog_annotations":[{"gene_uniquename":"YLR114C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02443","reference_uniquename":"PMID:29761456"}],"product":"Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004104","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR114C"}


id: YLR115W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03226":null,"YLR115W":null},"has_protein_features":false,"name":"CFT2","ortholog_annotations":[{"gene_uniquename":"YLR115W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03226","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004105","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR115W"}


id: YLR116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00249":null,"YLR116W":null},"has_protein_features":false,"name":"MSL5","ortholog_annotations":[{"gene_uniquename":"YLR116W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00249","reference_uniquename":"PMID:29761456"}],"product":"Component of commitment complex; which defines first step in splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004106","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR116W"}


id: YLR117C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00911":null,"YLR117C":null},"has_protein_features":false,"name":"CLF1","ortholog_annotations":[{"gene_uniquename":"YLR117C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00911","reference_uniquename":"PMID:29761456"}],"product":"Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004107","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR117C"}


id: YLR118C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02268":null,"YLR118C":null},"has_protein_features":false,"name":"TML25","ortholog_annotations":[{"gene_uniquename":"YLR118C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02268","reference_uniquename":"PMID:29761456"}],"product":"Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004108","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR118C"}


id: YLR119W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SRN2","product":"Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus","secondary_identifier":"SGD:S000004109","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR119W"}


id: YLR120C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00109":null,"SJAG_00254":null,"SJAG_00784":null,"SJAG_02260":null,"YLR120C":null},"has_protein_features":false,"name":"YPS1","ortholog_annotations":[{"gene_uniquename":"YLR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00109","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00254","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00784","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR120C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02260","reference_uniquename":"PMID:29761456"}],"product":"Aspartic protease; hyperglycosylated member of the yapsin family of proteases, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; involved in nutrient limitation-induced cleavage of the extracellular inhibitory domain of signaling mucin Msb2p, resulting in activation of the filamentous growth MAPK pathway; involved with other yapsins in the cell wall integrity response; role in KEX2-independent processing of the alpha factor precursor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004110","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR120C"}


id: YLR120W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR121C","secondary_identifier":"SGD:S000028674","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR120W-A"}


id: YLR121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00109":null,"SJAG_00254":null,"SJAG_00784":null,"SJAG_02260":null,"YLR121C":null},"has_protein_features":false,"name":"YPS3","ortholog_annotations":[{"gene_uniquename":"YLR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00109","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00254","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00784","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02260","reference_uniquename":"PMID:29761456"}],"product":"Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004111","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR121C"}


id: YLR122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; partially overlaps dubious ORF YLR123C","secondary_identifier":"SGD:S000004112","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR122C"}


id: YLR123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif","secondary_identifier":"SGD:S000004113","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR123C"}


id: YLR124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004114","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR124W"}


id: YLR125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene","secondary_identifier":"SGD:S000004115","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR125W"}


id: YLR126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00811":null,"YLR126C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR126C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00811","reference_uniquename":"PMID:29761456"}],"product":"Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004116","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR126C"}


id: YLR127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03575":null,"YLR127C":null},"has_protein_features":false,"name":"APC2","ortholog_annotations":[{"gene_uniquename":"YLR127C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03575","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004117","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR127C"}


id: YLR128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00033":null,"YLR128W":null},"has_protein_features":false,"name":"DCN1","ortholog_annotations":[{"gene_uniquename":"YLR128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00033","reference_uniquename":"PMID:29761456"}],"product":"Scaffold-type E3 ligase; required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004118","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR128W"}


id: YLR129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02300":null,"YLR129W":null},"has_protein_features":false,"name":"DIP2","ortholog_annotations":[{"gene_uniquename":"YLR129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02300","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004119","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR129W"}


id: YLR130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04185":null,"YLR130C":null},"has_protein_features":false,"name":"ZRT2","ortholog_annotations":[{"gene_uniquename":"YLR130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04185","reference_uniquename":"PMID:29761456"}],"product":"Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004120","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR130C"}


id: YLR131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02252":null,"YLR131C":null},"has_protein_features":false,"name":"ACE2","ortholog_annotations":[{"gene_uniquename":"YLR131C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02252","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor required for septum destruction after cytokinesis; part of the RAM network that regulates polarity and morphogenesis; NES phosphorylation by RAM network kinase Cbk1p blocks nuclear exit in mother cells during the M/G1 transition, causing asymmetric localization to daughter cell nuclei, and increased Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; Spt16p is required for nuclear exclusion during G1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004121","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR131C"}


id: YLR132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01798":null,"YLR132C":null},"has_protein_features":false,"name":"USB1","ortholog_annotations":[{"gene_uniquename":"YLR132C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01798","reference_uniquename":"PMID:29761456"}],"product":"Putative poly(U)-specific 3'-to-5' RNA exonuclease; involved in 3'-end processing of U6 snRNA removing uridines and generating a terminal 2&#8242;,3&#8242; cyclic phosphate; essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants; homolog of S.pombe gene, mpn1 and human gene, hUSB1; mutations in hUSB1 are associated with a rare genodermatosis, poikiloderma with neutropenia (OMIM 604173)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004122","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR132C"}


id: YLR133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01918":null,"YLR133W":null},"has_protein_features":false,"name":"CKI1","ortholog_annotations":[{"gene_uniquename":"YLR133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01918","reference_uniquename":"PMID:29761456"}],"product":"Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004123","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR133W"}


id: YLR134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02734":null,"SJAG_03743":null,"SJAG_04842":null,"YLR134W":null},"has_protein_features":false,"name":"PDC5","ortholog_annotations":[{"gene_uniquename":"YLR134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02734","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03743","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04842","reference_uniquename":"PMID:29761456"}],"product":"Minor isoform of pyruvate decarboxylase; key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004124","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR134W"}


id: YLR135W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05180":null,"YLR135W":null},"has_protein_features":false,"name":"SLX4","ortholog_annotations":[{"gene_uniquename":"YLR135W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05180","reference_uniquename":"PMID:29761456"}],"product":"Endonuclease involved in processing DNA; acts during recombination, repair; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); cleaves branched structures in complex with Slx1p; involved in interstrand cross-link repair, Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress; FANCP-related factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004125","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR135W"}


id: YLR136C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04682":null,"YLR136C":null},"has_protein_features":false,"name":"TIS11","ortholog_annotations":[{"gene_uniquename":"YLR136C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04682","reference_uniquename":"PMID:29761456"}],"product":"mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; represses mitochondrial function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; TIS11 has a paralog, CTH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004126","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR136C"}


id: YLR137W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RKM5","product":"Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species","secondary_identifier":"SGD:S000004127","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR137W"}


id: YLR138W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01541":null,"YLR138W":null},"has_protein_features":false,"name":"NHA1","ortholog_annotations":[{"gene_uniquename":"YLR138W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01541","reference_uniquename":"PMID:29761456"}],"product":"Na+/H+ antiporter; involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004128","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR138W"}


id: YLR139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04929":null,"YLR139C":null},"has_protein_features":false,"name":"SLS1","ortholog_annotations":[{"gene_uniquename":"YLR139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04929","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial membrane protein; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004129","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR139C"}


id: YLR140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I","secondary_identifier":"SGD:S000004130","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR140W"}


id: YLR141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04766":null,"YLR141W":null},"has_protein_features":false,"name":"RRN5","ortholog_annotations":[{"gene_uniquename":"YLR141W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04766","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004131","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR141W"}


id: YLR142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01903":null,"YLR142W":null},"has_protein_features":false,"name":"PUT1","ortholog_annotations":[{"gene_uniquename":"YLR142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01903","reference_uniquename":"PMID:29761456"}],"product":"Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004132","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR142W"}


id: YLR143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04544":null,"YLR143W":null},"has_protein_features":false,"name":"DPH6","ortholog_annotations":[{"gene_uniquename":"YLR143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04544","reference_uniquename":"PMID:29761456"}],"product":"Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004133","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR143W"}


id: YLR144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00667":null,"SJAG_01017":null,"YLR144C":null},"has_protein_features":false,"name":"ACF2","ortholog_annotations":[{"gene_uniquename":"YLR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00667","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01017","reference_uniquename":"PMID:29761456"}],"product":"Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004134","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR144C"}


id: YLR145W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03952":null,"YLR145W":null},"has_protein_features":false,"name":"RMP1","ortholog_annotations":[{"gene_uniquename":"YLR145W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03952","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RNase MRP; RNase MRP processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004135","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR145W"}


id: YLR146C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04481":null,"YLR146C":null},"has_protein_features":false,"name":"SPE4","ortholog_annotations":[{"gene_uniquename":"YLR146C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04481","reference_uniquename":"PMID:29761456"}],"product":"Spermine synthase; required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004136","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR146C"}


id: YLR146W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function","secondary_identifier":"SGD:S000113566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR146W-A"}


id: YLR147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01301":null,"YLR147C":null},"has_protein_features":false,"name":"SMD3","ortholog_annotations":[{"gene_uniquename":"YLR147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01301","reference_uniquename":"PMID:29761456"}],"product":"Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004137","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR147C"}


id: YLR148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03005":null,"YLR148W":null},"has_protein_features":false,"name":"PEP3","ortholog_annotations":[{"gene_uniquename":"YLR148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03005","reference_uniquename":"PMID:29761456"}],"product":"Component of CORVET membrane tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004138","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR148W"}


id: YLR149C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04170":null,"YLR149C":null},"has_protein_features":false,"name":"GID11","ortholog_annotations":[{"gene_uniquename":"YLR149C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04170","reference_uniquename":"PMID:29761456"}],"product":"Substrate receptor of the glucose-induced degradation-deficient (GID) complex that targets gluconeogenic enzymes for proteasomal degradation upon switch from ethanol to glucose as a carbon source; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004139","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR149C"}


id: YLR149C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR149C-A"}


id: YLR150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04383":null,"YLR150W":null},"has_protein_features":false,"name":"STM1","ortholog_annotations":[{"gene_uniquename":"YLR150W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04383","reference_uniquename":"PMID:29761456"}],"product":"Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004140","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR150W"}


id: YLR151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02247":null,"YLR151C":null},"has_protein_features":false,"name":"PCD1","ortholog_annotations":[{"gene_uniquename":"YLR151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02247","reference_uniquename":"PMID:29761456"}],"product":"8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004141","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR151C"}


id: YLR152C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YLR152C is not an essential gene","secondary_identifier":"SGD:S000004142","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR152C"}


id: YLR153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02741":null,"YLR153C":null},"has_protein_features":false,"name":"ACS2","ortholog_annotations":[{"gene_uniquename":"YLR153C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02741","reference_uniquename":"PMID:29761456"}],"product":"Acetyl-coA synthetase isoform; along with Acs1p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004143","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR153C"}


id: YLR154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01884":null,"YLR154C":null},"has_protein_features":false,"name":"RNH203","ortholog_annotations":[{"gene_uniquename":"YLR154C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01884","reference_uniquename":"PMID:29761456"}],"product":"Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS3 that causes Aicardi-Goutieres syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004144","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154C"}


id: YLR154C-G
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-2","secondary_identifier":"SGD:S000028561","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154C-G"}


id: YLR154C-H
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-2; YLR154C-H has a paralog, YLR157C-C, that arose from a segmental duplication","secondary_identifier":"SGD:S000028562","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154C-H"}


id: YLR154W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 25S rRNA gene on the opposite strand","secondary_identifier":"SGD:S000028675","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154W-A"}


id: YLR154W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 25S rRNA gene on the opposite strand","secondary_identifier":"SGD:S000028563","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154W-B"}


id: YLR154W-C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TAR1","product":"Protein potentially involved in regulation of respiratory metabolism; located in the mitochondria; interacts genetically with RPO41 and physically with Coq5p; encoded within the 25S rRNA gene on the opposite strand","secondary_identifier":"SGD:S000028422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154W-C"}


id: YLR154W-E
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 35S rRNA gene on the opposite strand","secondary_identifier":"SGD:S000028676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154W-E"}


id: YLR154W-F
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 35S rRNA gene on the opposite strand","secondary_identifier":"SGD:S000028843","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR154W-F"}


id: YLR155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ASP3-1","product":"Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from wine yeast Wickerhamomyces anomalus or close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-1 has paralog ASP3-3 that arose from a segmental duplication","secondary_identifier":"SGD:S000004145","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR155C"}


id: YLR156C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; partially overlaps RND5-3; YLR156C-A has a paralog, YLR159C-A, that arose from a segmental duplication","secondary_identifier":"SGD:S000028564","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR156C-A"}


id: YLR156W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; exhibits a two-hybrid interaction with Jsn1p in a large-scale analysis; YLR156W has a paralog, YLR159W, that arose from a segmental duplication","secondary_identifier":"SGD:S000004146","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR156W"}


id: YLR157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ASP3-2","product":"Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-2 has a paralog, ASP3-4, that arose from a segmental duplication","secondary_identifier":"SGD:S000004147","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR157C"}


id: YLR157C-C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-4; YLR157C-C has a paralog, YLR154C-H, that arose from a segmental duplication","secondary_identifier":"SGD:S000028565","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR157C-C"}


id: YLR157W-D
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; YLR157W-D has a paralog, YLR161W, that arose from a segmental duplication","secondary_identifier":"SGD:S000028677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR157W-D"}


id: YLR157W-E
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function identified by gene-trapping; microarray-based expression analysis, and genome-wide homology searching; partially overlaps a Ty1 element","secondary_identifier":"SGD:S000028678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR157W-E"}


id: YLR158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ASP3-3","product":"Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-3 has a paralog, ASP3-1, that arose from a segmental duplication","secondary_identifier":"SGD:S000004148","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR158C"}


id: YLR159C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; partially overlaps RND5-5; YLR159C-A has a paralog, YLR156C-A, that arose from a segmental duplication","secondary_identifier":"SGD:S000028566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR159C-A"}


id: YLR159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames in S288C encoded near the ribosomal DNA region of chromosome 12; YLR159W has a paralog, YLR156W, that arose from a segmental duplication","secondary_identifier":"SGD:S000004149","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR159W"}


id: YLR160C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ASP3-4","product":"Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-4 has a paralog, ASP3-2, that arose from a segmental duplication","secondary_identifier":"SGD:S000004150","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR160C"}


id: YLR161W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames in S288C encoded near the ribosomal DNA region of chromosome 12; YLR161W has a paralog, YLR157W-D, that arose from a segmental duplication","secondary_identifier":"SGD:S000004151","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR161W"}


id: YLR162W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; overexpression confers resistance to the antimicrobial peptide MiAMP1 and causes growth arrest, apoptosis, and increased sensitivity to cobalt chloride","secondary_identifier":"SGD:S000004152","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR162W"}


id: YLR162W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRT15","product":"Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; identified in a screen for mutants with decreased levels of rDNA transcription","secondary_identifier":"SGD:S000028567","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR162W-A"}


id: YLR163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02397":null,"YLR163C":null},"has_protein_features":false,"name":"MAS1","ortholog_annotations":[{"gene_uniquename":"YLR163C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02397","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004153","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR163C"}


id: YLR163W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000028844","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR163W-A"}


id: YLR164W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02398":null,"YLR164W":null},"has_protein_features":false,"name":"SHH4","ortholog_annotations":[{"gene_uniquename":"YLR164W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02398","reference_uniquename":"PMID:29761456"}],"product":"Putative alternate subunit of succinate dehydrogenase (SDH); mitochondrial inner membrane protein; genetic interaction with SDH4 suggests that Shh4p can function as a functional SDH subunit; a fraction copurifies with SDH subunit Sdh3p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner; Shh4p has greater similarity to human SDHD (subunit D of SDH, implicated in paraganglioma) than does its paralog Sdh4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004154","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR164W"}


id: YLR165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PUS5","product":"Pseudouridine synthase; catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability","secondary_identifier":"SGD:S000004155","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR165C"}


id: YLR166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04044":null,"YLR166C":null},"has_protein_features":false,"name":"SEC10","ortholog_annotations":[{"gene_uniquename":"YLR166C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04044","reference_uniquename":"PMID:29761456"}],"product":"Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004156","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR166C"}


id: YLR167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01226":null,"SJAG_02253":null,"YLR167W":null},"has_protein_features":false,"name":"RPS31","ortholog_annotations":[{"gene_uniquename":"YLR167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01226","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02253","reference_uniquename":"PMID:29761456"}],"product":"Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004157","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR167W"}


id: YLR168C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00576":null,"YLR168C":null},"has_protein_features":false,"name":"UPS2","ortholog_annotations":[{"gene_uniquename":"YLR168C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00576","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial intermembrane space protein; involved in phospholipid metabolism; forms complex with Mdm35p that transfers phosphatidylserine from outer membrane to inner membrane for phosphatidylethanolamine synthesis; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI; UPS2 has a paralog, UPS3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004158","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR168C"}


id: YLR169W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004159","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR169W"}


id: YLR170C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00379":null,"YLR170C":null},"has_protein_features":false,"name":"APS1","ortholog_annotations":[{"gene_uniquename":"YLR170C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00379","reference_uniquename":"PMID:29761456"}],"product":"Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004160","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR170C"}


id: YLR171W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004161","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR171W"}


id: YLR172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02467":null,"YLR172C":null},"has_protein_features":false,"name":"DPH5","ortholog_annotations":[{"gene_uniquename":"YLR172C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02467","reference_uniquename":"PMID:29761456"}],"product":"Methyltransferase required for synthesis of diphthamide; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004162","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR172C"}


id: YLR173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TAG1","product":"Vacuolar membrane protein involved in termination of autophagy; regulates autophagy termination during persistent nitrogen starvation through Atg1p-mediated re-phosphorylation of Atg13p and PAS disassembly; type II membrane protein containing hydrophobic transmembrane region with N-terminal region oriented toward cytosol and C-terminus inside lumen; luminal domain is glycosylated; forms foci in vacuole membrane during starvation; targeted to vacuole via AP-3 pathway","secondary_identifier":"SGD:S000004163","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR173W"}


id: YLR174W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04362":null,"YLR174W":null},"has_protein_features":false,"name":"IDP2","ortholog_annotations":[{"gene_uniquename":"YLR174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04362","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication; mutation in human homolog IDH1 is associated with low-grade gliomas and secondary glioblastomas","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004164","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR174W"}


id: YLR175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04754":null,"YLR175W":null},"has_protein_features":false,"name":"CBF5","ortholog_annotations":[{"gene_uniquename":"YLR175W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04754","reference_uniquename":"PMID:29761456"}],"product":"Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs; acts on large and small rRNAs, on snRNA U2, and on some mRNAs; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita; small nucleolar ribonucleoprotein particles are also known as snoRNPs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004165","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR175W"}


id: YLR176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04839":null,"YLR176C":null},"has_protein_features":false,"name":"RFX1","ortholog_annotations":[{"gene_uniquename":"YLR176C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04839","reference_uniquename":"PMID:29761456"}],"product":"Major transcriptional repressor of DNA-damage-regulated genes; recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004166","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR176C"}


id: YLR177W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04686":null,"YLR177W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04686","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004167","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR177W"}


id: YLR178C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TFS1","product":"Inhibitor of carboxypeptidase Y (Prc1p), and Ras GAP (Ira2p); phosphatidylethanolamine-binding protein (PEBP) family member and ortholog of hPEBP1/RKIP, a natural metastasis suppressor; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004168","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR178C"}


id: YLR179C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus","secondary_identifier":"SGD:S000004169","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR179C"}


id: YLR180W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03659":null,"YLR180W":null},"has_protein_features":false,"name":"SAM1","ortholog_annotations":[{"gene_uniquename":"YLR180W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03659","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004170","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR180W"}


id: YLR181C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04047":null,"YLR181C":null},"has_protein_features":false,"name":"VTA1","ortholog_annotations":[{"gene_uniquename":"YLR181C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04047","reference_uniquename":"PMID:29761456"}],"product":"Multivesicular body (MVB) protein; involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004171","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR181C"}


id: YLR182W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02810":null,"YLR182W":null},"has_protein_features":false,"name":"SWI6","ortholog_annotations":[{"gene_uniquename":"YLR182W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02810","reference_uniquename":"PMID:29761456"}],"product":"Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004172","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR182W"}


id: YLR183C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04512":null,"YLR183C":null},"has_protein_features":false,"name":"TOS4","ortholog_annotations":[{"gene_uniquename":"YLR183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04512","reference_uniquename":"PMID:29761456"}],"product":"Putative transcription factor, contains Forkhead Associated domain; binds chromatin; involved in expression homeostasis, buffering of mRNA synthesis rate against gene dosage changes during S phase; target of SBF transcription factor; expression is periodic and peaks in G1; involved in DNA replication checkpoint response; interacts with Rpd3 and Set3 histone deacetylase complexes; APCC(Cdh1) substrate; relative distribution to nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004173","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR183C"}


id: YLR184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004174","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR184W"}


id: YLR185W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01194":null,"SJAG_03326":null,"YLR185W":null},"has_protein_features":false,"name":"RPL37A","ortholog_annotations":[{"gene_uniquename":"YLR185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01194","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03326","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L37A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004175","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR185W"}


id: YLR186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02024":null,"YLR186W":null},"has_protein_features":false,"name":"EMG1","ortholog_annotations":[{"gene_uniquename":"YLR186W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02024","reference_uniquename":"PMID:29761456"}],"product":"Methyltransferase for rRNA; methylates pseudouridine 18S rRNA residue 1191; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independent of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and equivalent yeast mutation affects Emg1p dimerization and localization but not methyltransferase activity; human EMG1 complements lethality of null and ts mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004176","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR186W"}


id: YLR187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SKG3","product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004177","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR187W"}


id: YLR188W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MDL1","product":"Mitochondrial inner membrane half-type ABC transporter; mediates export of peptides generated upon proteolysis of mitochondrial proteins; plays a role in the regulation of cellular resistance to oxidative stress","secondary_identifier":"SGD:S000004178","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR188W"}


id: YLR189C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG26","product":"UDP-glucose:sterol glucosyltransferase; conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy","secondary_identifier":"SGD:S000004179","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR189C"}


id: YLR190W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MMR1","product":"Phospholipid binding protein; interacts with mitochondria and with Myo2p, functioning as an adaptor that recruits Myo2p and facilitates actin-based transport of mitochondria to the bud; mediates mitochondria anchorage at the bud tip; phosphorylated protein that localizes to the mitochondrial outer membrane; mRNA is targeted to the bud via the transport system involving She2p; member of the DSL1 family of tethering proteins","secondary_identifier":"SGD:S000004180","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR190W"}


id: YLR191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02693":null,"YLR191W":null},"has_protein_features":false,"name":"PEX13","ortholog_annotations":[{"gene_uniquename":"YLR191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02693","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal importomer complex component; integral peroxisomal membrane protein required for docking and translocation of peroxisomal matrix proteins; interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p; forms a complex with Pex14p and Pex17p; human homolog PEX13 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004181","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR191W"}


id: YLR192C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04900":null,"YLR192C":null},"has_protein_features":false,"name":"HCR1","ortholog_annotations":[{"gene_uniquename":"YLR192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04900","reference_uniquename":"PMID:29761456"}],"product":"eIF3j component of translation initiation factor 3 (eIF3); role in initiation as a substoichiometric component of eIF3; 60S ribosomal subunit recycling accessory factor; involved in nonsense-mediated mRNA decay (NMD); required for 20S pre-rRNA processing; post-transcriptional role in retrotransposition; absence decreases Ty1 Gag protein levels; binds eIF3 subunits Rpg1p, Prt1p and 18S rRNA; eIF3 promotes programmed stop codon readthrough; human homolog EIF3J can complement a yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004182","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR192C"}


id: YLR193C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00230":null,"YLR193C":null},"has_protein_features":false,"name":"UPS1","ortholog_annotations":[{"gene_uniquename":"YLR193C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00230","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004183","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR193C"}


id: YLR194C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NCW2","product":"GPI-anchored protein involved in cell wall remodeling; involved in the assembly of the cell wall chitin-glucan structure and repair of damage caused by the antifungal agent polyhexamethylene biguanide; role in the cell wall integrity pathway; expression is upregulated in response to cell wall stress; transported to the cell surface after Pmt1p-Pmt2p-mediated O-mannosylation, colocalizing with bud scars","secondary_identifier":"SGD:S000004184","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR194C"}


id: YLR195C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00102":null,"YLR195C":null},"has_protein_features":false,"name":"NMT1","ortholog_annotations":[{"gene_uniquename":"YLR195C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00102","reference_uniquename":"PMID:29761456"}],"product":"N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004185","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR195C"}


id: YLR196W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01153":null,"YLR196W":null},"has_protein_features":false,"name":"PWP1","ortholog_annotations":[{"gene_uniquename":"YLR196W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01153","reference_uniquename":"PMID:29761456"}],"product":"Protein with WD-40 repeats involved in rRNA processing; associates with rDNA chromatin in H4-tail-dependent manner; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004186","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR196W"}


id: YLR197W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02377":null,"YLR197W":null},"has_protein_features":false,"name":"NOP56","ortholog_annotations":[{"gene_uniquename":"YLR197W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02377","reference_uniquename":"PMID:29761456"}],"product":"Essential evolutionarily-conserved nucleolar protein; component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004187","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR197W"}


id: YLR198C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W","secondary_identifier":"SGD:S000004188","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR198C"}


id: YLR199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PBA1","product":"Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly","secondary_identifier":"SGD:S000004189","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR199C"}


id: YLR200W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01545":null,"YLR200W":null},"has_protein_features":false,"name":"YKE2","ortholog_annotations":[{"gene_uniquename":"YLR200W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01545","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the heterohexameric Gim/prefoldin protein complex; involved in the folding of alpha-tubulin, beta-tubulin, and actin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004190","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR200W"}


id: YLR201C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01866":null,"YLR201C":null},"has_protein_features":false,"name":"COQ9","ortholog_annotations":[{"gene_uniquename":"YLR201C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01866","reference_uniquename":"PMID:29761456"}],"product":"Protein required for ubiquinone biosynthesis and respiratory growth; localizes to matrix face of mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; ubiquinone is also known as coenzyme Q; human homolog COQ9 can complement yeast coq9 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004191","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR201C"}


id: YLR202C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron","secondary_identifier":"SGD:S000004192","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR202C"}


id: YLR203C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02979":null,"YLR203C":null},"has_protein_features":false,"name":"MSS51","ortholog_annotations":[{"gene_uniquename":"YLR203C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02979","reference_uniquename":"PMID:29761456"}],"product":"Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; localizes to vacuole membrane in response to H2O2; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004193","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR203C"}


id: YLR204W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00077":null,"YLR204W":null},"has_protein_features":false,"name":"QRI5","ortholog_annotations":[{"gene_uniquename":"YLR204W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00077","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein; required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004194","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR204W"}


id: YLR205C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HMX1","product":"ER localized heme oxygenase; involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants","secondary_identifier":"SGD:S000004195","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR205C"}


id: YLR206W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04644":null,"YLR206W":null},"has_protein_features":false,"name":"ENT2","ortholog_annotations":[{"gene_uniquename":"YLR206W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04644","reference_uniquename":"PMID:29761456"}],"product":"Epsin-like protein required for endocytosis and actin patch assembly; K48-, K63-specific Ub chain binding protein that functions as an endocytic adaptor; contains clathrin-binding motif at C-terminus; functionally redundant with Ent1p; ENT2 has a paralog, ENT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004196","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR206W"}


id: YLR207W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01709":null,"SJAG_04345":null,"YLR207W":null},"has_protein_features":false,"name":"HRD3","ortholog_annotations":[{"gene_uniquename":"YLR207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01709","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR207W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04345","reference_uniquename":"PMID:29761456"}],"product":"ER membrane protein that plays a central role in ERAD; forms HRD complex with Hrd1p and ER-associated protein degradation (ERAD) determinants that engages in lumen to cytosol communication and coordination of ERAD events","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004197","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR207W"}


id: YLR208W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03907":null,"YLR208W":null},"has_protein_features":false,"name":"SEC13","ortholog_annotations":[{"gene_uniquename":"YLR208W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03907","reference_uniquename":"PMID:29761456"}],"product":"Structural component of 3 complexes; subunit of the Nup84p nuclear pore subcomplex that contributes to nucleocytoplasmic transport and NPC biogenesis; subunit of the COPII vesicle coat required for ER-to-Golgi transport; subunit of SEACAT, a subcomplex of the coatomer-related, vacuolar-associated SEA complex, that inhibits the TORC1 inhibitory role of SEACIT (Iml1p-Npr2p-Npr3p), a GAP for Gtr1p, thereby resulting in activation of TORC1 signaling; human SEC13 homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004198","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR208W"}


id: YLR209C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01359":null,"YLR209C":null},"has_protein_features":false,"name":"PNP1","ortholog_annotations":[{"gene_uniquename":"YLR209C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01359","reference_uniquename":"PMID:29761456"}],"product":"Purine nucleoside phosphorylase; specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004199","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR209C"}


id: YLR210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03525":null,"SJAG_03699":null,"YLR210W":null},"has_protein_features":false,"name":"CLB4","ortholog_annotations":[{"gene_uniquename":"YLR210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03525","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR210W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03699","reference_uniquename":"PMID:29761456"}],"product":"B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; CLB4 has a paralog, CLB3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004200","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR210W"}


id: YLR211C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04860":null,"YLR211C":null},"has_protein_features":false,"name":"ATG38","ortholog_annotations":[{"gene_uniquename":"YLR211C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04860","reference_uniquename":"PMID:29761456"}],"product":"Homodimeric subunit of autophagy-specific PtdIns-3-kinase complex I; required for the integrity of the active PtdIns-3-kinase complex I by maintaining an association between Vps15p-Vps34p and Atg14p-Vps30p subcomplexes; localizes to the pre-autophagosomal structure (PAS) in an Atg14p-dependent manner; ATG38 is non-essential but is required for macroautophagy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004201","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR211C"}


id: YLR212C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01215":null,"YLR212C":null},"has_protein_features":false,"name":"TUB4","ortholog_annotations":[{"gene_uniquename":"YLR212C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01215","reference_uniquename":"PMID:29761456"}],"product":"Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress; null mutation is complemented by human TUBG1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004202","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR212C"}


id: YLR213C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04327":null,"YLR213C":null},"has_protein_features":false,"name":"CRR1","ortholog_annotations":[{"gene_uniquename":"YLR213C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04327","reference_uniquename":"PMID:29761456"}],"product":"Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004203","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR213C"}


id: YLR214W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04743":null,"YLR214W":null},"has_protein_features":false,"name":"FRE1","ortholog_annotations":[{"gene_uniquename":"YLR214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04743","reference_uniquename":"PMID:29761456"}],"product":"Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004204","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR214W"}


id: YLR215C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00353":null,"YLR215C":null},"has_protein_features":false,"name":"CDC123","ortholog_annotations":[{"gene_uniquename":"YLR215C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00353","reference_uniquename":"PMID:29761456"}],"product":"Assembly factor for the eIF2 translation initiation factor complex; regulates translational initiation; conserved residues of this ATP-Grasp protein that bind to ATP-Mg2+ in the pombe ortholog are required for complex assembly in budding yeast; interaction with eIF2 subunit Gcd11p facilitates complex assembly and activity; required for the START transition and timely progression through G2; regulated by nutrient availability; human ortholog complements the yeast mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004205","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR215C"}


id: YLR216C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04352":null,"YLR216C":null},"has_protein_features":false,"name":"CPR6","ortholog_annotations":[{"gene_uniquename":"YLR216C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04352","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; plays a role in determining prion variants; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004206","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR216C"}


id: YLR217W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6","secondary_identifier":"SGD:S000004207","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR217W"}


id: YLR218C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04116":null,"YLR218C":null},"has_protein_features":false,"name":"COA4","ortholog_annotations":[{"gene_uniquename":"YLR218C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04116","reference_uniquename":"PMID:29761456"}],"product":"Twin Cx(9)C protein involved in cytochrome c oxidase organization; organization includes assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors; mutation can be complemented by human COA4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004208","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR218C"}


id: YLR219W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MSC3","product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004209","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR219W"}


id: YLR220W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04867":null,"YLR220W":null},"has_protein_features":false,"name":"CCC1","ortholog_annotations":[{"gene_uniquename":"YLR220W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04867","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to vacuole decreases upon DNA replication stress; targeted to vacuole via AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004210","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR220W"}


id: YLR221C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04992":null,"YLR221C":null},"has_protein_features":false,"name":"RSA3","ortholog_annotations":[{"gene_uniquename":"YLR221C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04992","reference_uniquename":"PMID:29761456"}],"product":"Protein with a likely role in ribosomal maturation; required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004211","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR221C"}


id: YLR222C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04224":null,"YLR222C":null},"has_protein_features":false,"name":"UTP13","ortholog_annotations":[{"gene_uniquename":"YLR222C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04224","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004212","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR222C"}


id: YLR222C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene IFH1","secondary_identifier":"SGD:S000028568","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR222C-A"}


id: YLR223C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02671":null,"YLR223C":null},"has_protein_features":false,"name":"IFH1","ortholog_annotations":[{"gene_uniquename":"YLR223C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02671","reference_uniquename":"PMID:29761456"}],"product":"Coactivator, regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing; regulated by acetylation and phosphorylation at different growth states via TORC1 signaling; IFH1 has a paralog, CRF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004213","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR223C"}


id: YLR224W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UCC1","product":"F-box protein and component of SCF ubiquitin ligase complexes; involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; SCF-Ucc1 regulates level of Cit2 citrate synthase protein to maintain citrate homeostasis, acts as metabolic switch for glyoxylate cycle; UCC1 transcription is downregulated in cells grown on C2-compounds","secondary_identifier":"SGD:S000004214","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR224W"}


id: YLR225C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YLR225C has a paralog, YDR222W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004215","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR225C"}


id: YLR226W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01213":null,"YLR226W":null},"has_protein_features":false,"name":"BUR2","ortholog_annotations":[{"gene_uniquename":"YLR226W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01213","reference_uniquename":"PMID:29761456"}],"product":"Cyclin for the Sgv1p (Bur1p) protein kinase; subunit of the CDK-cyclin BUR kinase complex with Sgv1p (Bur1p); regulates Set2p-dependent H3K36 trimethylation; regulates transcriptional elongation through the phosphorylation of the carboxy-terminal domain (CTD) of Rpo21p; involved in the recruitment of Spt6p to the CTD at the onset of transcription; regulates telomere elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004216","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR226W"}


id: YLR227C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ADY4","product":"Structural component of the meiotic outer plaque; outer plaque is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane","secondary_identifier":"SGD:S000004217","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR227C"}


id: YLR228C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM22","product":"Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes upon sterol depletion, after relocating from intracellular membranes to perinuclear foci; redundant activator of filamentation with UPC2, up-regulating the expression of genes involved in filamentous growth; contains Zn[2]-Cys[6] binuclear cluster; ECM22 has a paralog, UPC2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004218","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR228C"}


id: YLR229C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04509":null,"YLR229C":null},"has_protein_features":false,"name":"CDC42","ortholog_annotations":[{"gene_uniquename":"YLR229C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04509","reference_uniquename":"PMID:29761456"}],"product":"Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; acts with ESCRT proteins at sites of nuclear envelope and ER fission; mutants have defects in the organization of actin and septins; human homolog CDC42 can complement yeast cdc42 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004219","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR229C"}


id: YLR230W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42/YLR229C gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity","secondary_identifier":"SGD:S000004220","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR230W"}


id: YLR231C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BNA5","product":"Kynureninase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p","secondary_identifier":"SGD:S000004221","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR231C"}


id: YLR232W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5","secondary_identifier":"SGD:S000004222","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR232W"}


id: YLR233C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00939":null,"YLR233C":null},"has_protein_features":false,"name":"EST1","ortholog_annotations":[{"gene_uniquename":"YLR233C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00939","reference_uniquename":"PMID:29761456"}],"product":"TLC1 RNA-associated factor involved in telomere length regulation; recruitment subunit of telomerase; has G-quadruplex promoting activity required for telomere elongation; role in activating telomere-bound Est2p-TLC1-RNA; EST1 has a paralog, EBS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004223","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR233C"}


id: YLR234W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04816":null,"YLR234W":null},"has_protein_features":false,"name":"TOP3","ortholog_annotations":[{"gene_uniquename":"YLR234W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04816","reference_uniquename":"PMID:29761456"}],"product":"DNA Topoisomerase III; conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially; DNA catenation/decatenation activity is stimulated by RPA and Sgs1p-Top3p-Rmi1p; involved in telomere stability and regulation of mitotic recombination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004224","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR234W"}


id: YLR235C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORFs TOP3/YLR234W and YLR236C","secondary_identifier":"SGD:S000004225","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR235C"}


id: YLR236C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; overlaps ORF YLR235C","secondary_identifier":"SGD:S000004226","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR236C"}


id: YLR237W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"THI7","product":"Plasma membrane transporter responsible for the uptake of thiamine; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia","secondary_identifier":"SGD:S000004227","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR237W"}


id: YLR238W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04455":null,"YLR238W":null},"has_protein_features":false,"name":"FAR10","ortholog_annotations":[{"gene_uniquename":"YLR238W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04455","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate; FAR10 has a paralog, VPS64, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004228","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR238W"}


id: YLR239C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01271":null,"YLR239C":null},"has_protein_features":false,"name":"LIP2","ortholog_annotations":[{"gene_uniquename":"YLR239C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01271","reference_uniquename":"PMID:29761456"}],"product":"Lipoyl ligase; involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004229","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR239C"}


id: YLR240W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00114":null,"YLR240W":null},"has_protein_features":false,"name":"VPS34","ortholog_annotations":[{"gene_uniquename":"YLR240W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00114","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004230","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR240W"}


id: YLR241W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03895":null,"YLR241W":null},"has_protein_features":false,"name":"CSC1","ortholog_annotations":[{"gene_uniquename":"YLR241W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03895","reference_uniquename":"PMID:29761456"}],"product":"Calcium permeable gated cation channel; functions as an osmosensitive, calcium-permeable cation channel when expressed in a heterologous system; may be involved in detoxification; similar to Arabidopsis CSC1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004231","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR241W"}


id: YLR242C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00261":null,"YLR242C":null},"has_protein_features":false,"name":"ARV1","ortholog_annotations":[{"gene_uniquename":"YLR242C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00261","reference_uniquename":"PMID:29761456"}],"product":"Cortical ER protein; implicated in the membrane insertion of tail-anchored C-terminal single transmembrane domain proteins; may function in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution; human ARV1, required for normal cholesterol and bile acid homeostasis, can complement yeast arv1 null mutant; human variant causing early onset epileptic encephalopathy is unable to rescue the yeast null","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004232","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR242C"}


id: YLR243W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01655":null,"YLR243W":null},"has_protein_features":false,"name":"GPN3","ortholog_annotations":[{"gene_uniquename":"YLR243W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01655","reference_uniquename":"PMID:29761456"}],"product":"Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; may have a role in sister chromatid cohesion; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004233","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR243W"}


id: YLR244C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02033":null,"YLR244C":null},"has_protein_features":false,"name":"MAP1","ortholog_annotations":[{"gene_uniquename":"YLR244C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02033","reference_uniquename":"PMID:29761456"}],"product":"Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p; apo-Map1p is activated by the GTP-dependent zinc transferase Zng1p, especially during zinc starvation; interacts with Zng1p via an N-terminal Zn finger domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004234","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR244C"}


id: YLR245C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01673":null,"YLR245C":null},"has_protein_features":false,"name":"CDD1","ortholog_annotations":[{"gene_uniquename":"YLR245C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01673","reference_uniquename":"PMID:29761456"}],"product":"Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004235","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR245C"}


id: YLR246W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04451":null,"YLR246W":null},"has_protein_features":false,"name":"ERF2","ortholog_annotations":[{"gene_uniquename":"YLR246W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04451","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a palmitoyltransferase; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole; palmitoyltransferase is composed of Erf2p and Shr5p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR246W"}


id: YLR247C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00111":null,"YLR247C":null},"has_protein_features":false,"name":"IRC20","ortholog_annotations":[{"gene_uniquename":"YLR247C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00111","reference_uniquename":"PMID:29761456"}],"product":"E3 ubiquitin ligase and putative helicase; involved in synthesis-dependent strand annealing-mediated homologous recombination; ensures precise end-joining along with Srs2p in the Yku70p/Yku80p/Lig4p-dependent NHEJ pathway; controls 2-micron plasmid copy number by regulating the levels of the Flp1p recombinase; localizes to both the mitochondrion and the nucleus; contains a Snf2/Swi2 family ATPase/helicase and a RING finger domain; null mutant displays increased levels of spontaneous Rad52p foci","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR247C"}


id: YLR248W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01084":null,"SJAG_01855":null,"YLR248W":null},"has_protein_features":false,"name":"RCK2","ortholog_annotations":[{"gene_uniquename":"YLR248W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01084","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR248W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01855","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR248W"}


id: YLR249W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02738":null,"YLR249W":null},"has_protein_features":false,"name":"YEF3","ortholog_annotations":[{"gene_uniquename":"YLR249W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02738","reference_uniquename":"PMID:29761456"}],"product":"Translation elongation factor 3; contains two ABC cassettes; binds and hydrolyzes ATP; interacts with mRNA independently of translation; involved in frameshifting at stalled ribosomes; YEF3 has a paralog, HEF3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR249W"}


id: YLR250W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00751":null,"YLR250W":null},"has_protein_features":false,"name":"SSP120","ortholog_annotations":[{"gene_uniquename":"YLR250W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00751","reference_uniquename":"PMID:29761456"}],"product":"Protein packaged into COPII vesicles for ER to Golgi trafficking; forms a complex with Emp47p that may function in trafficking plasma membrane glycoproteins through early secretory pathway; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004240","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR250W"}


id: YLR251W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00631":null,"YLR251W":null},"has_protein_features":false,"name":"SYM1","ortholog_annotations":[{"gene_uniquename":"YLR251W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00631","reference_uniquename":"PMID:29761456"}],"product":"Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; lysine auxotroph proposed to function in pyrimidine metabolism; homologous to mammalian peroxisomal membrane protein Mpv17; human homolog MPV17 is implicated in hepatocerebral mtDNA depletion syndromes (MDDS), and complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR251W"}


id: YLR252W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism","secondary_identifier":"SGD:S000004242","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR252W"}


id: YLR253W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02064":null,"YLR253W":null},"has_protein_features":false,"name":"CQD2","ortholog_annotations":[{"gene_uniquename":"YLR253W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02064","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein involved in lipid homeostasis; involved in mobilization of CoQ from its site of synthesis on the inner mitochondrial membrane to other sites of action; associates with mitochondrial ribosome; involved in mitochondrial morphology; non-essential gene which interacts genetically with MDM10, and other members of ERMES complex; transcription is periodic during metabolic cycle; homologous to human aarF domain containing kinase, ADCK1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004243","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR253W"}


id: YLR254C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NDL1","product":"Homolog of nuclear distribution factor NudE; NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends; localizes to cytosol, nucleus and peroxisomes","secondary_identifier":"SGD:S000004244","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR254C"}


id: YLR255C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000004245","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR255C"}


id: YLR256W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HAP1","product":"Zinc finger transcription factor; involved in the complex regulation of gene expression in response to levels of heme and oxygen; localizes to the mitochondrion as well as to the nucleus; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus","secondary_identifier":"SGD:S000004246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR256W"}


id: YLR257W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000004247","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR257W"}


id: YLR258W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GSY2","product":"Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress","secondary_identifier":"SGD:S000004248","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR258W"}


id: YLR259C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00564":null,"YLR259C":null},"has_protein_features":false,"name":"HSP60","ortholog_annotations":[{"gene_uniquename":"YLR259C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00564","reference_uniquename":"PMID:29761456"}],"product":"Tetradecameric mitochondrial chaperonin; required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004249","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR259C"}


id: YLR260W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02429":null,"YLR260W":null},"has_protein_features":false,"name":"LCB5","ortholog_annotations":[{"gene_uniquename":"YLR260W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02429","reference_uniquename":"PMID:29761456"}],"product":"Minor sphingoid long-chain base kinase; possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules; LCB5 has a paralog, LCB4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004250","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR260W"}


id: YLR261C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VPS63","product":"Putative protein of unknown function; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect; decreased levels of protein in enolase deficient mutant","secondary_identifier":"SGD:S000004251","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR261C"}


id: YLR262C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05030":null,"YLR262C":null},"has_protein_features":false,"name":"YPT6","ortholog_annotations":[{"gene_uniquename":"YLR262C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05030","reference_uniquename":"PMID:29761456"}],"product":"Rab family GTPase; required for endosome-to-Golgi, intra-Golgi retrograde, and retrograde Golgi-to-ER transport; temporarily at the Golgi, dissociating into the cytosol on arrival of the late Golgi GTPase Ypt32p; Golgi-localized form is GTP bound, while cytosolic form is GDP-bound; required for delivery of Atg9p to the phagophore assembly site during autophagy under heat stress, with Ypt6p for starvation induced autophagy and for the CVT pathway; homolog of mammalian Rab6","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004252","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR262C"}


id: YLR262C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TMA7","product":"Protein of unknown function that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000007246","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR262C-A"}


id: YLR263W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04748":null,"YLR263W":null},"has_protein_features":false,"name":"RED1","ortholog_annotations":[{"gene_uniquename":"YLR263W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04748","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the synaptonemal complex axial elements; involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; promotes interhomolog recombination by phosphorylating Hop1p; also interacts with Mec3p and Ddc1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004253","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR263W"}


id: YLR264C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR264C-A"}


id: YLR264W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02749":null,"SJAG_04746":null,"YLR264W":null},"has_protein_features":false,"name":"RPS28B","ortholog_annotations":[{"gene_uniquename":"YLR264W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02749","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR264W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04746","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; has an extraribosomal function in autoregulation, in which Rps28Bp binds to a decapping complex via Edc3p, which then binds to RPS28B mRNA leading to its decapping and degradation; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004254","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR264W"}


id: YLR265C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04199":null,"YLR265C":null},"has_protein_features":false,"name":"NEJ1","ortholog_annotations":[{"gene_uniquename":"YLR265C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04199","reference_uniquename":"PMID:29761456"}],"product":"DNA end-binding protein required for nonhomologous end joining (NHEJ); subunit of the DNA ligase IV complex involved in initial end binding, intermolecular ligation, and DNA ligase reactivation after completion of repair; phosphorylation by Tpk1p is required for DNA damage induced NHEJ and for nuclear targeting of Nej1p and Lif1p; human homolog NHEJ1 is phosphorylated by human Tpk1p homolog PRKACB, regulating NHEJ; transcriptionally repressed by MAT heterozygosity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004255","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR265C"}


id: YLR266C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PDR8","product":"Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR266C"}


id: YLR267W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BOP2","product":"Protein of unknown function","secondary_identifier":"SGD:S000004257","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR267W"}


id: YLR268W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00557":null,"YLR268W":null},"has_protein_features":false,"name":"SEC22","ortholog_annotations":[{"gene_uniquename":"YLR268W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00557","reference_uniquename":"PMID:29761456"}],"product":"R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004258","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR268W"}


id: YLR269C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004259","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR269C"}


id: YLR270W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01625":null,"YLR270W":null},"has_protein_features":false,"name":"DCS1","ortholog_annotations":[{"gene_uniquename":"YLR270W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01625","reference_uniquename":"PMID:29761456"}],"product":"Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; acts as inhibitor of neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress; DCS1 has a paralog, DCS2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004260","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR270W"}


id: YLR271W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01380":null,"YLR271W":null},"has_protein_features":false,"name":"CMG1","ortholog_annotations":[{"gene_uniquename":"YLR271W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01380","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004261","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR271W"}


id: YLR272C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03161":null,"YLR272C":null},"has_protein_features":false,"name":"YCS4","ortholog_annotations":[{"gene_uniquename":"YLR272C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03161","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004262","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR272C"}


id: YLR273C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PIG1","product":"Putative targeting subunit for type-1 protein phosphatase Glc7p; tethers Glc7p to Gsy2p glycogen synthase; PIG1 has a paralog, GAC1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004263","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR273C"}


id: YLR274W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01354":null,"YLR274W":null},"has_protein_features":false,"name":"MCM5","ortholog_annotations":[{"gene_uniquename":"YLR274W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01354","reference_uniquename":"PMID:29761456"}],"product":"Component of the Mcm2-7 hexameric helicase complex; MCM complex is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004264","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR274W"}


id: YLR275W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02304":null,"YLR275W":null},"has_protein_features":false,"name":"SMD2","ortholog_annotations":[{"gene_uniquename":"YLR275W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02304","reference_uniquename":"PMID:29761456"}],"product":"Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004265","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR275W"}


id: YLR276C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04650":null,"YLR276C":null},"has_protein_features":false,"name":"DBP9","ortholog_annotations":[{"gene_uniquename":"YLR276C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04650","reference_uniquename":"PMID:29761456"}],"product":"DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004266","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR276C"}


id: YLR277C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04587":null,"YLR277C":null},"has_protein_features":false,"name":"YSH1","ortholog_annotations":[{"gene_uniquename":"YLR277C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04587","reference_uniquename":"PMID:29761456"}],"product":"Endoribonuclease; subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs; protein abundance increases in response to DNA replication stress; YSH1 has a paralog, SYC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004267","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR277C"}


id: YLR278C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; associates with rDNA chromatin in vivo; YLR278C is not an essential gene","secondary_identifier":"SGD:S000004268","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR278C"}


id: YLR279W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004269","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR279W"}


id: YLR280C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004270","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR280C"}


id: YLR281C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00308":null,"YLR281C":null},"has_protein_features":false,"name":"RSO55","ortholog_annotations":[{"gene_uniquename":"YLR281C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00308","reference_uniquename":"PMID:29761456"}],"product":"Stalled-ribosome rescue factor srRF2; mitochondrial protein required for respiratory growth in presence of bacteriostatic ribosome-binding antibiotics; not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004271","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR281C"}


id: YLR282C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition","secondary_identifier":"SGD:S000004272","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR282C"}


id: YLR283W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03505":null,"YLR283W":null},"has_protein_features":false,"name":"PUT7","ortholog_annotations":[{"gene_uniquename":"YLR283W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03505","reference_uniquename":"PMID:29761456"}],"product":"Regulator of mitochondrial proline metabolism; tethered with Fmp32p to inner mitochondrial membrane in large hetero-oligomeric complex, abundance of which is regulated by proline; involved in mitochondrial proline homeostasis and cellular redox balance; null exhibits pronounced defect in proline utilization, and can be functionally complemented by expression of human homolog MCUR1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004273","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR283W"}


id: YLR284C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECI1","product":"Peroxisomal delta3,delta2-enoyl-CoA isomerase; hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced; ECI1 has a paralog, DCI1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004274","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR284C"}


id: YLR285C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028569","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR285C-A"}


id: YLR285W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01425":null,"YLR285W":null},"has_protein_features":false,"name":"NNT1","ortholog_annotations":[{"gene_uniquename":"YLR285W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01425","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine-dependent methyltransferase; novel N-terminal protein methyltransferase that trimethylates the N-terminal glycine residue (G2) and also dimethylates lysine (K3) on elongation factor eEF1A (Tef1p/Tef2p); has a role in rDNA silencing and in lifespan determination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004275","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR285W"}


id: YLR286C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00620":null,"YLR286C":null},"has_protein_features":false,"name":"CTS1","ortholog_annotations":[{"gene_uniquename":"YLR286C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00620","reference_uniquename":"PMID:29761456"}],"product":"Endochitinase; required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004276","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR286C"}


id: YLR286W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene CTS1","secondary_identifier":"SGD:S000028679","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR286W-A"}


id: YLR287C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04390":null,"YLR287C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YLR287C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04390","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004277","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR287C"}


id: YLR287C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01287":null,"SJAG_02224":null,"YLR287C-A":null},"has_protein_features":false,"name":"RPS30A","ortholog_annotations":[{"gene_uniquename":"YLR287C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01287","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR287C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02224","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004278","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR287C-A"}


id: YLR288C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03026":null,"YLR288C":null},"has_protein_features":false,"name":"MEC3","ortholog_annotations":[{"gene_uniquename":"YLR288C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03026","reference_uniquename":"PMID:29761456"}],"product":"DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004279","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR288C"}


id: YLR289W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04351":null,"YLR289W":null},"has_protein_features":false,"name":"GUF1","ortholog_annotations":[{"gene_uniquename":"YLR289W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04351","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial matrix GTPase; associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004280","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR289W"}


id: YLR290C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01820":null,"YLR290C":null},"has_protein_features":false,"name":"COQ11","ortholog_annotations":[{"gene_uniquename":"YLR290C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01820","reference_uniquename":"PMID:29761456"}],"product":"Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes; required for synthesis of wild-type levels of Coenzyme Q (ubiquinone); member of the short-chain dehydrogenase/reductase (SDR) superfamily; orthologous gene in some other fungi is fused to the COQ10 ortholog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004281","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR290C"}


id: YLR291C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01576":null,"YLR291C":null},"has_protein_features":false,"name":"GCD7","ortholog_annotations":[{"gene_uniquename":"YLR291C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01576","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as negative regulator of GCN4 expression; mutations in human ortholog EIF2B2 cause fatal brain disease childhood ataxia with central nervous system hypomyelination (CACH); human ortholog can complement yeast mutant, allows growth down-regulation of yeast gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004282","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR291C"}


id: YLR292C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03955":null,"YLR292C":null},"has_protein_features":false,"name":"SEC72","ortholog_annotations":[{"gene_uniquename":"YLR292C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03955","reference_uniquename":"PMID:29761456"}],"product":"Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and translocation into the ER; other members are Sec63p, Sec62p, and Sec66p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004283","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR292C"}


id: YLR293C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01449":null,"YLR293C":null},"has_protein_features":false,"name":"GSP1","ortholog_annotations":[{"gene_uniquename":"YLR293C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01449","reference_uniquename":"PMID:29761456"}],"product":"Ran GTPase; GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; GSP1 has a paralog, GSP2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004284","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR293C"}


id: YLR294C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14","secondary_identifier":"SGD:S000004285","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR294C"}


id: YLR295C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00542":null,"YLR295C":null},"has_protein_features":false,"name":"ATP14","ortholog_annotations":[{"gene_uniquename":"YLR295C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00542","reference_uniquename":"PMID:29761456"}],"product":"Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004286","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR295C"}


id: YLR296W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains","secondary_identifier":"SGD:S000004287","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR296W"}


id: YLR297W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004288","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR297W"}


id: YLR298C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03983":null,"YLR298C":null},"has_protein_features":false,"name":"YHC1","ortholog_annotations":[{"gene_uniquename":"YLR298C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03983","reference_uniquename":"PMID:29761456"}],"product":"Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004289","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR298C"}


id: YLR299C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene ECM38","secondary_identifier":"SGD:S000028680","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR299C-A"}


id: YLR299W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01612":null,"SJAG_03316":null,"YLR299W":null},"has_protein_features":false,"name":"ECM38","ortholog_annotations":[{"gene_uniquename":"YLR299W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01612","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR299W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03316","reference_uniquename":"PMID:29761456"}],"product":"Gamma-glutamyltranspeptidase; major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004290","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR299W"}


id: YLR300W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01171":null,"SJAG_01888":null,"SJAG_05001":null,"YLR300W":null},"has_protein_features":false,"name":"EXG1","ortholog_annotations":[{"gene_uniquename":"YLR300W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01171","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR300W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01888","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR300W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05001","reference_uniquename":"PMID:29761456"}],"product":"Major exo-1,3-beta-glucanase of the cell wall; involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes; EXG1 has a paralog, SPR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004291","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR300W"}


id: YLR301W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HRI1","product":"Protein of unknown function that interacts with Sec72p and Hrr25p","secondary_identifier":"SGD:S000004292","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR301W"}


id: YLR302C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000004293","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR302C"}


id: YLR303W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02972":null,"YLR303W":null},"has_protein_features":false,"name":"MET17","ortholog_annotations":[{"gene_uniquename":"YLR303W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02972","reference_uniquename":"PMID:29761456"}],"product":"O-acetyl homoserine-O-acetyl serine sulfhydrylase; involved in methionine and cysteine biosynthesis; long considered essential for inorganic sulfur assimilation, but inefficient homocysteine synthase Hsu1p enables met17 null cells to assimilate enough inorganic sulfur for survival and proliferation; growth failure of met17 null can be explained by toxic accumulation of H2S gas due to a metabolic bottleneck","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004294","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR303W"}


id: YLR304C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03588":null,"YLR304C":null},"has_protein_features":false,"name":"ACO1","ortholog_annotations":[{"gene_uniquename":"YLR304C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03588","reference_uniquename":"PMID:29761456"}],"product":"Aconitase; required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy; mutation in human homolog ACO2 is associated with dominant optic nerve atrophy; human homolog ACO2 can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004295","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR304C"}


id: YLR305C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04537":null,"YLR305C":null},"has_protein_features":false,"name":"STT4","ortholog_annotations":[{"gene_uniquename":"YLR305C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04537","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol-4-kinase; functions in Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization; required for autophagosome-vacuole fusion during autophagy and for lipophagy in stationary phase cells and during nitrogen starvation; localizes to plasma membrane and mitochondria in HTP studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004296","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR305C"}


id: YLR306W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01018":null,"YLR306W":null},"has_protein_features":false,"name":"UBC12","ortholog_annotations":[{"gene_uniquename":"YLR306W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01018","reference_uniquename":"PMID:29761456"}],"product":"Enzyme that mediates the conjugation of Rub1p; a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004297","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR306W"}


id: YLR307C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DPA10","product":"Putative mitochondrial protein of unknown function","secondary_identifier":"SGD:S000028525","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR307C-A"}


id: YLR307W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03013":null,"YLR307W":null},"has_protein_features":false,"name":"CDA1","ortholog_annotations":[{"gene_uniquename":"YLR307W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03013","reference_uniquename":"PMID:29761456"}],"product":"Chitin deacetylase; together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004298","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR307W"}


id: YLR308W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03013":null,"YLR308W":null},"has_protein_features":false,"name":"CDA2","ortholog_annotations":[{"gene_uniquename":"YLR308W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03013","reference_uniquename":"PMID:29761456"}],"product":"Chitin deacetylase; together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004299","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR308W"}


id: YLR309C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00144":null,"SJAG_03838":null,"YLR309C":null},"has_protein_features":false,"name":"IMH1","ortholog_annotations":[{"gene_uniquename":"YLR309C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00144","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR309C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03838","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in vesicular transport; mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004300","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR309C"}


id: YLR310C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02486":null,"SJAG_02819":null,"YLR310C":null},"has_protein_features":false,"name":"CDC25","ortholog_annotations":[{"gene_uniquename":"YLR310C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02486","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR310C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02819","reference_uniquename":"PMID:29761456"}],"product":"Membrane bound guanine nucleotide exchange factor; also known as a GEF or GDP-release factor; indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1; thermosensitivity of the cdc25-5 mutant is functionally complemented by human RASGRF1 or by a fragment of human SOS1 comprising the CDC25-related catalytic domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004301","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR310C"}


id: YLR311C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000004302","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR311C"}


id: YLR312C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG39","product":"Transmembrane receptor with a role in nucleophagy; involved in selective autophagy of the endoplasmic reticulum and nucleus in response to nitrogen starvation or rapamycin treatment; role in nuclear envelope deformation to generate nucleus-derived double-membrane vesicles (NDVs), interacting with Atg8p to target these NDVs to forming autophagosomal membranes; anchored in the outer nuclear membrane, associating with the inner nuclear membrane via amphipathic helices","secondary_identifier":"SGD:S000004303","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR312C"}


id: YLR312C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YLR312C-B was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, SPH1/YLR313C","secondary_identifier":"SGD:S000028570","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR312C-B"}


id: YLR312W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01463":null,"YLR312W-A":null},"has_protein_features":false,"name":"MRPL15","ortholog_annotations":[{"gene_uniquename":"YLR312W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01463","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004304","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR312W-A"}


id: YLR313C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03625":null,"YLR313C":null},"has_protein_features":false,"name":"SPH1","ortholog_annotations":[{"gene_uniquename":"YLR313C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03625","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in shmoo formation and bipolar bud site selection; localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p; SPH1 has a paralog, SPA2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004305","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR313C"}


id: YLR314C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01277":null,"SJAG_03688":null,"YLR314C":null},"has_protein_features":false,"name":"CDC3","ortholog_annotations":[{"gene_uniquename":"YLR314C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01277","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR314C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03688","reference_uniquename":"PMID:26896847"}],"product":"Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000004306","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR314C"}


id: YLR315W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00350":null,"YLR315W":null},"has_protein_features":false,"name":"NKP2","ortholog_annotations":[{"gene_uniquename":"YLR315W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00350","reference_uniquename":"PMID:29761456"}],"product":"Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004307","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR315W"}


id: YLR316C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00352":null,"YLR316C":null},"has_protein_features":false,"name":"TAD3","ortholog_annotations":[{"gene_uniquename":"YLR316C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00352","reference_uniquename":"PMID:29761456"}],"product":"Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs; localizes to cytosol, nucleus and peroxisomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004308","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR316C"}


id: YLR317W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C","secondary_identifier":"SGD:S000004309","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR317W"}


id: YLR318W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05979":null,"YLR318W":null},"has_protein_features":false,"name":"EST2","ortholog_annotations":[{"gene_uniquename":"YLR318W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05979","reference_uniquename":"PMID:29761456"}],"product":"Reverse transcriptase subunit of the telomerase holoenzyme; essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004310","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR318W"}


id: YLR319C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04624":null,"YLR319C":null},"has_protein_features":false,"name":"BUD6","ortholog_annotations":[{"gene_uniquename":"YLR319C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04624","reference_uniquename":"PMID:29761456"}],"product":"Actin- and formin-interacting protein; nucleation-promoting factor (NPF) for Bni1p and Bnr1p during actin cable assembly and organization; enhances Bnr1p-mediated actin nucleation, alleviating Hof1p inhibition through competitive binding; interacts with Bni1p via a C-terminal triple helical coiled-coil domain; role in polarized cell growth; isolated as a bipolar budding mutant; localizes to the presumptive bud site, small bud tips, the bud neck and secretory vesicles; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004311","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR319C"}


id: YLR320W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04971":null,"YLR320W":null},"has_protein_features":false,"name":"MMS22","ortholog_annotations":[{"gene_uniquename":"YLR320W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04971","reference_uniquename":"PMID:29761456"}],"product":"Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of replication fork, such as fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; Rtt101p-Mms22p ligase associates with replisome complex during S phase via Ctf4p; required for accurate meiotic chromosome segregation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004312","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR320W"}


id: YLR321C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04213":null,"YLR321C":null},"has_protein_features":false,"name":"SFH1","ortholog_annotations":[{"gene_uniquename":"YLR321C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04213","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog; hSNF5 tumor suppressor ortholog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004313","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR321C"}


id: YLR322W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VPS65","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth","secondary_identifier":"SGD:S000004314","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR322W"}


id: YLR323C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03112":null,"YLR323C":null},"has_protein_features":false,"name":"CWC24","ortholog_annotations":[{"gene_uniquename":"YLR323C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03112","reference_uniquename":"PMID:29761456"}],"product":"General splicing factor; required for stable U2 snRNP binding to primary transcripts; essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; similar to S. pombe Cwf24p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004315","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR323C"}


id: YLR324W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PEX30","product":"ER-resident protein involved in peroxisomal biogenesis; ER-localized protein that associates with peroxisomes; interacts with Pex29p and reticulons Rtn1p and Yop1p to regulate peroxisome biogenesis from the ER; role in peroxisomal-destined vesicular flow from the ER; partially redundant with Pex31p; may function at a step downstream of steps mediated by Pex28p and Pex29p; PEX30 has a paralog, PEX31, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004316","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR324W"}


id: YLR325C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02081":null,"SJAG_04534":null,"YLR325C":null},"has_protein_features":false,"name":"RPL38","ortholog_annotations":[{"gene_uniquename":"YLR325C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02081","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YLR325C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04534","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000004317","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR325C"}


id: YLR326W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery; predicted to be palmitoylated","secondary_identifier":"SGD:S000004318","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR326W"}


id: YLR327C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TMA10","product":"Protein of unknown function that associates with ribosomes; protein abundance increases in response to DNA replication stress; TMA10 has a paralog, STF2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000004319","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YLR327C"}


