# genes

id: YDR518W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00288":null,"YDR518W":null},"has_protein_features":false,"name":"EUG1","ortholog_annotations":[{"gene_uniquename":"YDR518W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00288","reference_uniquename":"PMID:29761456"}],"product":"Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002926","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR518W"}


id: YDR519W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FPR2","product":"Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress; mutation is functionally complemented by human FKBP2","secondary_identifier":"SGD:S000002927","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR519W"}


id: YDR520C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04712":null,"YDR520C":null},"has_protein_features":false,"name":"URC2","ortholog_annotations":[{"gene_uniquename":"YDR520C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04712","reference_uniquename":"PMID:29761456"}],"product":"Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002928","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR520C"}


id: YDR521W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol","secondary_identifier":"SGD:S000002929","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR521W"}


id: YDR522C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00340":null,"SJAG_03483":null,"YDR522C":null},"has_protein_features":false,"name":"SPS2","ortholog_annotations":[{"gene_uniquename":"YDR522C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00340","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR522C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03483","reference_uniquename":"PMID:29761456"}],"product":"Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002930","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR522C"}


id: YDR523C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02022":null,"YDR523C":null},"has_protein_features":false,"name":"SPS1","ortholog_annotations":[{"gene_uniquename":"YDR523C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02022","reference_uniquename":"PMID:29761456"}],"product":"STE20-family GCKIII protein kinase; required for prospore membrane closure, efficient spore packaging, and localization of enzymes involved in spore wall synthesis; component of a non-canonical Hippo pathway with Cdc15p involved in spindle disassembly and sustained release of Cdc14p during anaphase II; forms a complex with Cdc15p;  phosphorylation requires Cdc15p; required for Ssp1p phosphorylation and turnover; interacts with 14-3-3 proteins; expressed in late meiosis; nuclear and cytoplasmic","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002931","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR523C"}


id: YDR524C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01600":null,"SJAG_02277":null,"YDR524C":null},"has_protein_features":false,"name":"AGE1","ortholog_annotations":[{"gene_uniquename":"YDR524C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01600","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR524C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02277","reference_uniquename":"PMID:26896847"}],"product":"ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002932","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR524C"}


id: YDR524C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028616","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR524C-A"}


id: YDR524C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication","secondary_identifier":"SGD:S000028739","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR524C-B"}


id: YDR524W-C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin","secondary_identifier":"SGD:S000028740","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR524W-C"}


id: YDR525W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"API2","product":"Putative protein of unknown function; conserved among S. cerevisiae strains; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology","secondary_identifier":"SGD:S000002933","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR525W"}


id: YDR525W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SNA2","product":"Protein of unknown function; has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern","secondary_identifier":"SGD:S000007236","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR525W-A"}


id: YDR526C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002934","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR526C"}


id: YDR527W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04559":null,"YDR527W":null},"has_protein_features":false,"name":"RBA50","ortholog_annotations":[{"gene_uniquename":"YDR527W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04559","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002935","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR527W"}


id: YDR528W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HLR1","product":"Protein involved in regulation of cell wall composition and integrity; also involved in cell wall response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; HLR1 has a paralog, LRE1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002936","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR528W"}


id: YDR529C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03490":null,"YDR529C":null},"has_protein_features":false,"name":"QCR7","ortholog_annotations":[{"gene_uniquename":"YDR529C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03490","reference_uniquename":"PMID:29761456"}],"product":"Subunit 7 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002937","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR529C"}


id: YDR530C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"APA2","product":"Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002938","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR530C"}


id: YDR531W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00427":null,"YDR531W":null},"has_protein_features":false,"name":"CAB1","ortholog_annotations":[{"gene_uniquename":"YDR531W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00427","reference_uniquename":"PMID:29761456"}],"product":"Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase; cytoplasmic enzyme that catalyzes the first committed step in the universal biosynthetic pathway for coenzyme A (CoA) synthesis; transcription is regulated by Upc2p via a sterol response element; overexpressed human homologs, PANK1 and PANK3, complement yeast hypomorphic alleles, while PANK2, a gene implicated in pantothenate-kinase associated neurodegeneration, partially complements after the mitochondrial transit peptide is removed","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002939","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR531W"}


id: YDR532C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03327":null,"YDR532C":null},"has_protein_features":false,"name":"KRE28","ortholog_annotations":[{"gene_uniquename":"YDR532C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03327","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Spc105p; modified by sumoylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002940","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR532C"}


id: YDR533C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02988":null,"SJAG_04674":null,"YDR533C":null},"has_protein_features":false,"name":"HSP31","ortholog_annotations":[{"gene_uniquename":"YDR533C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02988","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR533C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04674","reference_uniquename":"PMID:29761456"}],"product":"Methylglyoxalase that converts methylglyoxal to D-lactate; involved in oxidative stress resistance, diauxic shift, and stationary phase survival; has similarity to E. coli Hsp31 and C. albicans Glx3p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002941","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR533C"}


id: YDR534C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FIT1","product":"Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall","secondary_identifier":"SGD:S000002942","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR534C"}


id: YDR535C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene","secondary_identifier":"SGD:S000002943","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR535C"}


id: YDR536W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04905":null,"YDR536W":null},"has_protein_features":false,"name":"STL1","ortholog_annotations":[{"gene_uniquename":"YDR536W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR536W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR536W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR536W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YDR536W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Glycerol proton symporter of the plasma membrane; subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002944","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR536W"}


id: YDR537C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps verified ORF PAD1/YDR538W","secondary_identifier":"SGD:S000002945","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR537C"}


id: YDR538W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAD1","product":"Phenylacrylic acid decarboxylase; decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; confers resistance to cinnamic acid; overexpression of both Pad1p and Fdc1p increases cinnamic acid decarboxylase activity due to the Pad1p-catalyzed formation of a diffusible cofactor required for Fdc1p activity; contains mRNA binding activity; homolog of E. coli UbiX","secondary_identifier":"SGD:S000002946","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR538W"}


id: YDR539W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FDC1","product":"Ferulic acid decarboxylase; involved in the decarboxylation of aromatic carboxylic acids such as phenylacrylic (cinnamic) acid, ferulic acid and coumaric acid and formation of the corresponding vinyl derivatives; overexpression of both Pad1p and Fdc1p increases decarboxylase activity due to the Pad1p-catalyzed formation of a diffusible cofactor required for Fdc1p activity; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm in an HTP study","secondary_identifier":"SGD:S000002947","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR539W"}


id: YDR540C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC4","product":"Protein similar to bacterial secreted DfsB proteins; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus","secondary_identifier":"SGD:S000002948","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR540C"}


id: YDR541C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02960":null,"YDR541C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YDR541C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02960","reference_uniquename":"PMID:29761456"}],"product":"Aldehyde reductase; substrates include both aromatic and aliphatic aldehydes; uses NADPH as cofactor; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002949","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR541C"}


id: YDR542W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU10","product":"Protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to the vacuole; member of the seripauperin multigene family encoded mainly in subtelomeric regions","secondary_identifier":"SGD:S000002950","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR542W"}


id: YDR543C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002951","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR543C"}


id: YDR544C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002952","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR544C"}


id: YDR545C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YRF1-1/YDR545W","secondary_identifier":"SGD:S000028617","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR545C-A"}


id: YDR545W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YRF1-1","product":"Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p","secondary_identifier":"SGD:S000002953","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YDR545W"}


id: YEL001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC22","product":"Protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci","secondary_identifier":"SGD:S000000727","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL001C"}


id: YEL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01069":null,"YEL002C":null},"has_protein_features":false,"name":"WBP1","ortholog_annotations":[{"gene_uniquename":"YEL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01069","reference_uniquename":"PMID:29761456"}],"product":"Non-catalytic beta subunit of the oligosaccharyltransferase (OST) complex; the OST complex catalyzes N-linked glycosylation of newly synthesized proteins in the ER; forms a pocket with Ost2p involved in binding terminal glucose units of the donor glycan; human homolog DDOST can complement yeast growth defect during down-regulation of the yeast gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000728","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL002C"}


id: YEL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05191":null,"YEL003W":null},"has_protein_features":false,"name":"GIM4","ortholog_annotations":[{"gene_uniquename":"YEL003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05191","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the heterohexameric cochaperone prefoldin complex; complex binds specifically to cytosolic chaperonin and transfers target proteins to it","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000729","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL003W"}


id: YEL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00434":null,"YEL004W":null},"has_protein_features":false,"name":"YEA4","ortholog_annotations":[{"gene_uniquename":"YEL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00434","reference_uniquename":"PMID:29761456"}],"product":"Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter; required for cell wall chitin synthesis; localized to the ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000730","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL004W"}


id: YEL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VAB2","product":"Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Vps21p-GFP; has potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of; Vab2p-GFP-fusion localizes to cytoplasm in punctate pattern","secondary_identifier":"SGD:S000000731","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL005C"}


id: YEL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04328":null,"YEL006W":null},"has_protein_features":false,"name":"YEA6","ortholog_annotations":[{"gene_uniquename":"YEL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04328","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial NAD+ transporter; member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog; YEA6 has a paralog, YIA6, that arose from the whole genome duplication; human NAD+ transporter MCART1/SLC25A51 functionally complements the yia6 yea6 double null mutant, and yeast YEA6 reciprocally complements defects in MCART1/SLC25A51 null cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000732","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL006W"}


id: YEL007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02921":null,"SJAG_04920":null,"YEL007W":null},"has_protein_features":false,"name":"MIT1","ortholog_annotations":[{"gene_uniquename":"YEL007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02921","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04920","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000733","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL007W"}


id: YEL008C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028618","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL008C-A"}


id: YEL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YEL008W is not an essential gene; predicted to be involved in metabolism","secondary_identifier":"SGD:S000000734","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL008W"}


id: YEL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GCN4","product":"bZIP transcriptional activator of amino acid biosynthetic genes;  activator responds to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels; contains four upstream open reading frames (uORFs) in 5' untranslated region which regulate translation","secondary_identifier":"SGD:S000000735","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL009C"}


id: YEL009C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; overlaps ORF YEL010W","secondary_identifier":"SGD:S000028741","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL009C-A"}


id: YEL010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000736","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL010W"}


id: YEL011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GLC3","product":"Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; glycogen accumulation defect of the null mutant is functionally complemented by human GBE1, which is associated with glycogen storage disease","secondary_identifier":"SGD:S000000737","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL011W"}


id: YEL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00855":null,"YEL012W":null},"has_protein_features":false,"name":"UBC8","ortholog_annotations":[{"gene_uniquename":"YEL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00855","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-conjugating enzyme that regulates gluconeogenesis; negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000738","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL012W"}


id: YEL013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00029":null,"YEL013W":null},"has_protein_features":false,"name":"VAC8","ortholog_annotations":[{"gene_uniquename":"YEL013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00029","reference_uniquename":"PMID:29761456"}],"product":"Vacuole-specific Myo2p receptor; Myo2p-Vac17p-Vac8p transport complex subunit required for vacuolar inheritance; mediates anchoring of phosphatidylinositol 3-kinase complex I (PIK3C3-C1) to autophagosome; required with Atg13p for the vesicle closure step of the cytoplasm-to-vacuole (CVT) pathway, for homotypic vacuole-vacuole fusion and for nucleus-vacuole junction formation with Nvj1p; contains 11 armadillo (ARM) repeats; myristoylated, palmitoylated, and phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000739","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL013W"}


id: YEL014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000000740","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL014C"}


id: YEL015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04640":null,"YEL015W":null},"has_protein_features":false,"name":"EDC3","ortholog_annotations":[{"gene_uniquename":"YEL015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04640","reference_uniquename":"PMID:29761456"}],"product":"Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; mediates decay of the RPS28B mRNA via binding to both Rps28Bp (or Rps28Ap) and the RPS28B mRNA; mediates decay of the YRA1 mRNA by a different, translation-independent mechanism; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000741","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL015W"}


id: YEL016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00705":null,"YEL016C":null},"has_protein_features":false,"name":"NPP2","ortholog_annotations":[{"gene_uniquename":"YEL016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00705","reference_uniquename":"PMID:29761456"}],"product":"Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; NPP2 has a paralog, NPP1, that arose from the whole genome duplication; npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to single mutants","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000742","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL016C"}


id: YEL017C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PMP2","product":"Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002103","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL017C-A"}


id: YEL017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GTT3","product":"Protein of unknown function may be involved in glutathione metabolism; function suggested by computational analysis of large-scale protein-protein interaction data; N- and C-terminal fusion proteins localize to the cell periphery","secondary_identifier":"SGD:S000000743","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL017W"}


id: YEL018C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF EAF5/YEL018W","secondary_identifier":"SGD:S000028742","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL018C-A"}


id: YEL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EAF5","product":"Non-essential subunit of the NuA4 acetyltransferase complex; Esa1p-associated factor; relocalizes to the cytosol in response to hypoxia","secondary_identifier":"SGD:S000000744","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL018W"}


id: YEL019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01776":null,"YEL019C":null},"has_protein_features":false,"name":"MMS21","ortholog_annotations":[{"gene_uniquename":"YEL019C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01776","reference_uniquename":"PMID:29761456"}],"product":"Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex; required for anchoring dsDNA breaks to the nuclear periphery; SMC5-SMC6 plays a key role in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; required for efficient sister chromatid cohesion; mutants are sensitive to MMS, show increased spontaneous mutation and mitotic recombination; SUMOylates and inhibits Snf1p function; supports nucleolar function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000745","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL019C"}


id: YEL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00706":null,"YEL020C":null},"has_protein_features":false,"name":"PXP1","ortholog_annotations":[{"gene_uniquename":"YEL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00706","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal matrix protein; well-conserved in fungi; contains tripartite homology domain of thiamine pyrophosphate (TPP) enzymes; targeted to peroxisomes by Pex5p; contains low sequence identity with Pdc1p; mRNA identified as translated by ribosome profiling data","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000746","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL020C"}


id: YEL020C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028544","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL020C-B"}


id: YEL020W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04208":null,"YEL020W-A":null},"has_protein_features":false,"name":"TIM9","ortholog_annotations":[{"gene_uniquename":"YEL020W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04208","reference_uniquename":"PMID:29761456"}],"product":"Essential protein of the mitochondrial intermembrane space; forms a complex with Tim10p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007256","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL020W-A"}


id: YEL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03164":null,"YEL021W":null},"has_protein_features":false,"name":"URA3","ortholog_annotations":[{"gene_uniquename":"YEL021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03164","reference_uniquename":"PMID:29761456"}],"product":"Orotidine-5'-phosphate (OMP) decarboxylase; catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000747","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL021W"}


id: YEL022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00858":null,"YEL022W":null},"has_protein_features":false,"name":"GEA2","ortholog_annotations":[{"gene_uniquename":"YEL022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00858","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000748","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL022W"}


id: YEL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene","secondary_identifier":"SGD:S000000749","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL023C"}


id: YEL024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00601":null,"YEL024W":null},"has_protein_features":false,"name":"RIP1","ortholog_annotations":[{"gene_uniquename":"YEL024W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00601","reference_uniquename":"PMID:29761456"}],"product":"Ubiquinol-cytochrome-c reductase; a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000750","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL024W"}


id: YEL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus","secondary_identifier":"SGD:S000000751","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL025C"}


id: YEL026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03410":null,"YEL026W":null},"has_protein_features":false,"name":"SNU13","ortholog_annotations":[{"gene_uniquename":"YEL026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03410","reference_uniquename":"PMID:29761456"}],"product":"RNA binding protein; part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000752","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL026W"}


id: YEL027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02782":null,"YEL027W":null},"has_protein_features":false,"name":"VMA3","ortholog_annotations":[{"gene_uniquename":"YEL027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02782","reference_uniquename":"PMID:29761456"}],"product":"Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase; dicyclohexylcarbodiimide binding subunit; required for vacuolar acidification and important for copper and iron metal ion homeostasis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000753","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL027W"}


id: YEL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YEL028W is not an essential gene","secondary_identifier":"SGD:S000000754","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL028W"}


id: YEL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00252":null,"SJAG_01383":null,"YEL029C":null},"has_protein_features":false,"name":"BUD16","ortholog_annotations":[{"gene_uniquename":"YEL029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00252","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01383","reference_uniquename":"PMID:29761456"}],"product":"Putative pyridoxal kinase; a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; localizes to cytosol and peroxisomes; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000755","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL029C"}


id: YEL030C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL030C-A"}


id: YEL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01615":null,"YEL030W":null},"has_protein_features":false,"name":"ECM10","ortholog_annotations":[{"gene_uniquename":"YEL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01615","reference_uniquename":"PMID:29761456"}],"product":"Heat shock protein of the Hsp70 family; localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; ECM10 has a paralog, SSC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000756","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL030W"}


id: YEL031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01435":null,"YEL031W":null},"has_protein_features":false,"name":"SPF1","ortholog_annotations":[{"gene_uniquename":"YEL031W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01435","reference_uniquename":"PMID:29761456"}],"product":"P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid and sterol composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1; null mutation is complemented by human Parkinson disease-related ATP13A1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000757","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL031W"}


id: YEL032C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028620","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL032C-A"}


id: YEL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01762":null,"YEL032W":null},"has_protein_features":false,"name":"MCM3","ortholog_annotations":[{"gene_uniquename":"YEL032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01762","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000758","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL032W"}


id: YEL033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MTC7","product":"Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant","secondary_identifier":"SGD:S000000759","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL033W"}


id: YEL034C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps HYP2/YEL034W, a verified gene that encodes eiF-5A","secondary_identifier":"SGD:S000028743","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL034C-A"}


id: YEL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02189":null,"SJAG_02812":null,"YEL034W":null},"has_protein_features":false,"name":"HYP2","ortholog_annotations":[{"gene_uniquename":"YEL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02189","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02812","reference_uniquename":"PMID:29761456"}],"product":"Translation elongation factor eIF-5A; required for translation of proteins containing polyproline stretches; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has paralog ANB1 that arose from whole genome duplication; in humans EIF5A variants cause a disorder characterized by variable combinations of developmental delay, microcephaly, micrognathia and dysmorphism; human EIF5A complements inviability of yeast hyp2 anb1 double null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000760","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL034W"}


id: YEL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UTR5","product":"Protein of unknown function; originally considered essential but deletion overlapped the TATA box of neighboring essential gene HYP2, while deletion that avoids the HYP2 TATA box is viable; transcription may be regulated by Gcr1p","secondary_identifier":"SGD:S000000761","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL035C"}


id: YEL036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00816":null,"YEL036C":null},"has_protein_features":false,"name":"ANP1","ortholog_annotations":[{"gene_uniquename":"YEL036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00816","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000762","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL036C"}


id: YEL037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00941":null,"YEL037C":null},"has_protein_features":false,"name":"RAD23","ortholog_annotations":[{"gene_uniquename":"YEL037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00941","reference_uniquename":"PMID:29761456"}],"product":"Proteasome-associated ubiquitin receptor; K48-specific Ub chain binding protein that recruits substrates to the proteasome; subunit of nuclear excision repair factor 2 (NER2) with Rad4p that binds damaged DNA during NER, linking repair to proteolysis; NER2 binds DDR gene promoters to repress transcription in the absence of damage; stimulates Png1p-induced protein deglycosylation; contains a Ub-like (UBL) and two Ub-associated (UBA) domains; UBA2 protects Rad23p from proteasomal degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000763","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL037C"}


id: YEL038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01404":null,"YEL038W":null},"has_protein_features":false,"name":"UTR4","ortholog_annotations":[{"gene_uniquename":"YEL038W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01404","reference_uniquename":"PMID:29761456"}],"product":"Protein with sequence similarity to acireductone synthases; involved in methionine salvage; found in both the cytoplasm and nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000764","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL038W"}


id: YEL039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02744":null,"YEL039C":null},"has_protein_features":false,"name":"CYC7","ortholog_annotations":[{"gene_uniquename":"YEL039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02744","reference_uniquename":"PMID:29761456"}],"product":"Cytochrome c isoform 2, expressed under hypoxic conditions; also known as iso-2-cytochrome c; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000765","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL039C"}


id: YEL040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04327":null,"YEL040W":null},"has_protein_features":false,"name":"UTR2","ortholog_annotations":[{"gene_uniquename":"YEL040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04327","reference_uniquename":"PMID:29761456"}],"product":"Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000766","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL040W"}


id: YEL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01566":null,"SJAG_01582":null,"YEL041W":null},"has_protein_features":false,"name":"YEF1","ortholog_annotations":[{"gene_uniquename":"YEL041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01566","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01582","reference_uniquename":"PMID:29761456"}],"product":"ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000767","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL041W"}


id: YEL042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01595":null,"YEL042W":null},"has_protein_features":false,"name":"GDA1","ortholog_annotations":[{"gene_uniquename":"YEL042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01595","reference_uniquename":"PMID:29761456"}],"product":"Guanosine diphosphatase located in the Golgi; involved in the transport of GDP-mannose into the Golgi lumen, converting GDP to GMP after mannose is transferred to substrates; null mutants are defective in sporulation and pre-meiotic S phase entry; orthologous to human ENTPD6, a meiosis-associated non-obstructive azoospermia (NOA) related gene identified in GWAS studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000768","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL042W"}


id: YEL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GTA1","product":"Protein of unknown function; proposed role in Golgi vesicle trafficking based on phenotypic profile, presence of a coiled-coil domain often associated with vesicle tethering proteins, and interaction profile process enrichment; may interact with ribosomes, based on co-purification studies; localizes to the ER and cell periphery in HTP studies; contains fibronectin type III domain fold","secondary_identifier":"SGD:S000000769","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL043W"}


id: YEL044W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02303":null,"YEL044W":null},"has_protein_features":false,"name":"IES6","ortholog_annotations":[{"gene_uniquename":"YEL044W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02303","reference_uniquename":"PMID:29761456"}],"product":"Component of the INO80 chromatin remodeling complex; critical for INO80 function; involved in regulation of chromosome segregation and maintenance of normal centromeric chromatin structure; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000770","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL044W"}


id: YEL045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress","secondary_identifier":"SGD:S000000771","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL045C"}


id: YEL046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02450":null,"YEL046C":null},"has_protein_features":false,"name":"GLY1","ortholog_annotations":[{"gene_uniquename":"YEL046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02450","reference_uniquename":"PMID:29761456"}],"product":"Threonine aldolase; catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000772","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL046C"}


id: YEL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00203":null,"YEL047C":null},"has_protein_features":false,"name":"FRD1","ortholog_annotations":[{"gene_uniquename":"YEL047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00203","reference_uniquename":"PMID:29761456"}],"product":"Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000773","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL047C"}


id: YEL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04618":null,"YEL048C":null},"has_protein_features":false,"name":"TCA17","ortholog_annotations":[{"gene_uniquename":"YEL048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04618","reference_uniquename":"PMID:29761456"}],"product":"Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; promotes association of TRAPPII-specific subunits with the TRAPP core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000774","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL048C"}


id: YEL049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU2","product":"Member of the seripauperin multigene family; encoded mainly in subtelomeric region; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme","secondary_identifier":"SGD:S000000775","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL049W"}


id: YEL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01829":null,"YEL050C":null},"has_protein_features":false,"name":"RML2","ortholog_annotations":[{"gene_uniquename":"YEL050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01829","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit (L2); has similarity to E. coli L2 ribosomal protein; mutant allele (fat21) causes inability to utilize oleate, and induce oleic acid oxidation; may interfere with activity of the Adr1p transcription factor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000776","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL050C"}


id: YEL050W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028545","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL050W-A"}


id: YEL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01817":null,"YEL051W":null},"has_protein_features":false,"name":"VMA8","ortholog_annotations":[{"gene_uniquename":"YEL051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01817","reference_uniquename":"PMID:29761456"}],"product":"Subunit D of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000777","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL051W"}


id: YEL052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04154":null,"YEL052W":null},"has_protein_features":false,"name":"AFG1","ortholog_annotations":[{"gene_uniquename":"YEL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04154","reference_uniquename":"PMID:29761456"}],"product":"Protein that may act as a chaperone for cytochrome c oxidase subunits; conserved protein; may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000778","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL052W"}


id: YEL053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03215":null,"YEL053C":null},"has_protein_features":false,"name":"MAK10","ortholog_annotations":[{"gene_uniquename":"YEL053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03215","reference_uniquename":"PMID:29761456"}],"product":"Non-catalytic subunit of the NatC N-terminal acetyltransferase; required for replication of dsRNA virus; expression is glucose-repressible; human NatC ortholog, Naa35, requires co-expression of the human catalytic subunit, Naa30, to functionally complement the null allele","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000779","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL053C"}


id: YEL053W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene RPL12A/YEL054C","secondary_identifier":"SGD:S000028744","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL053W-A"}


id: YEL054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02535":null,"SJAG_05248":null,"YEL054C":null},"has_protein_features":false,"name":"RPL12A","ortholog_annotations":[{"gene_uniquename":"YEL054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02535","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL054C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05248","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000780","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL054C"}


id: YEL055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05253":null,"YEL055C":null},"has_protein_features":false,"name":"POL5","ortholog_annotations":[{"gene_uniquename":"YEL055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05253","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in 60S assembly and pre-40S AFs recycling; has sequence similarity to human MybBP1A and weak sequence similarity to B-type DNA polymerases; not required for chromosomal DNA replication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000781","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL055C"}


id: YEL056W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02439":null,"SJAG_03867":null,"YEL056W":null},"has_protein_features":false,"name":"HAT2","ortholog_annotations":[{"gene_uniquename":"YEL056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02439","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YEL056W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03867","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000782","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL056W"}


id: YEL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SDD1","product":"Protein of unknown function; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; may have a role in telomere maintenance; target of UME6 regulation","secondary_identifier":"SGD:S000000783","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL057C"}


id: YEL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00978":null,"SJAG_03723":null,"YEL058W":null},"has_protein_features":false,"name":"PCM1","ortholog_annotations":[{"gene_uniquename":"YEL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00978","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03723","reference_uniquename":"PMID:29761456"}],"product":"Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL058W"}


id: YEL059C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SOM1","product":"Subunit of the mitochondrial inner membrane peptidase (IMP); IMP is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs","secondary_identifier":"SGD:S000002954","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL059C-A"}


id: YEL059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HHY1","product":"Putative protein of unknown function; null mutant is sensitive to heat, pH disturbances, ionic stress, and various chemicals; hypersensitivity to hygromycin B indicative of defects in vacuolar trafficking","secondary_identifier":"SGD:S000000785","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL059W"}


id: YEL060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02432":null,"SJAG_04785":null,"YEL060C":null},"has_protein_features":false,"name":"PRB1","ortholog_annotations":[{"gene_uniquename":"YEL060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02432","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04785","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar proteinase B yscB with H3 N-terminal endopeptidase activity; serine protease of subtilisin family; involved in protein degradation in vacuole; required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via AP-3 pathway; PRB1 has a paralog, YSP3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000786","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL060C"}


id: YEL061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04745":null,"YEL061C":null},"has_protein_features":false,"name":"CIN8","ortholog_annotations":[{"gene_uniquename":"YEL061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04745","reference_uniquename":"PMID:29761456"}],"product":"Bipolar kinesin motor protein; switches from minus- to plus-end-directed motility in vitro depending on conditions; involved in mitotic spindle assembly and chromosome segregation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000787","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL061C"}


id: YEL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02765":null,"YEL062W":null},"has_protein_features":false,"name":"NPR2","ortholog_annotations":[{"gene_uniquename":"YEL062W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02765","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of the SEA complex, a coatomer-related complex that associates dynamically with the vacuole; Npr2p may have a structural or regulatory role, supporting Iml1p function as a GAP for the Rag family GTPase Gtr1p, and resulting in inhibition of TORC1 signaling in response to amino acid deprivation; SEACIT is required for non-nitrogen-starvation-induced autophagy; homolog of human tumor suppressor NPRL2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000788","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL062W"}


id: YEL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CAN1","product":"Plasma membrane arginine permease; transceptor that senses extracellular basic amino acids; negative regulator of biofilm formation; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000789","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL063C"}


id: YEL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AVT2","product":"Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters","secondary_identifier":"SGD:S000000790","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL064C"}


id: YEL065W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02735":null,"SJAG_02834":null,"SJAG_03667":null,"YEL065W":null},"has_protein_features":false,"name":"SIT1","ortholog_annotations":[{"gene_uniquename":"YEL065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02735","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02834","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL065W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03667","reference_uniquename":"PMID:29761456"}],"product":"Ferrioxamine B transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000791","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL065W"}


id: YEL066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03288":null,"YEL066W":null},"has_protein_features":false,"name":"HPA3","ortholog_annotations":[{"gene_uniquename":"YEL066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03288","reference_uniquename":"PMID:29761456"}],"product":"D-Amino acid N-acetyltransferase that detoxifies D-amino acids; catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; acetylates histones and polyamines, also autoacetylates","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000792","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL066W"}


id: YEL067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000000793","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL067C"}


id: YEL068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum and mCherry fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000000794","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL068C"}


id: YEL069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YEL069C":null},"has_protein_features":false,"name":"HXT13","ortholog_annotations":[{"gene_uniquename":"YEL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YEL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YEL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YEL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000795","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL069C"}


id: YEL070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DSF1","product":"Mannitol dehydrogenase; deletion suppresses mutation of mpt5; DSF1 has a paralog, MAN2, that arose from a segmental duplication","secondary_identifier":"SGD:S000000796","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL070W"}


id: YEL071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03804":null,"YEL071W":null},"has_protein_features":false,"name":"DLD3","ortholog_annotations":[{"gene_uniquename":"YEL071W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03804","reference_uniquename":"PMID:29761456"}],"product":"2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase; converts D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate in the presence of FAD, with concomitant reduction of pyruvate to D-lactate; minor lactate dehydrogenase activity; component of the retrograde regulon that consists of genes whose expression are stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source; located in the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000797","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL071W"}


id: YEL072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RMD6","product":"Protein required for sporulation; localizes to the peroxisome","secondary_identifier":"SGD:S000000798","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL072W"}


id: YEL073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline","secondary_identifier":"SGD:S000000799","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL073C"}


id: YEL074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; large scale expression analysis showed an increase in mRNA accumulation in strains mutant for exosome components","secondary_identifier":"SGD:S000000800","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL074W"}


id: YEL075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000000801","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL075C"}


id: YEL075W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000002956","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL075W-A"}


id: YEL076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000000802","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL076C"}


id: YEL076C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000002955","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL076C-A"}


id: YEL077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Helicase-like protein encoded within the telomeric Y' element","secondary_identifier":"SGD:S000006409","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL077C"}


id: YEL077W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028621","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YEL077W-A"}


id: YER001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MNN1","product":"Alpha-1,3-mannosyltransferase; integral membrane glycoprotein of Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides; one of five S. cerevisiae proteins of MNN1 family; targeted to vacuole via AP-3 pathway","secondary_identifier":"SGD:S000000803","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER001W"}


id: YER002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01454":null,"YER002W":null},"has_protein_features":false,"name":"NOP16","ortholog_annotations":[{"gene_uniquename":"YER002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01454","reference_uniquename":"PMID:29761456"}],"product":"Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000804","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER002W"}


id: YER003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02648":null,"YER003C":null},"has_protein_features":false,"name":"PMI40","ortholog_annotations":[{"gene_uniquename":"YER003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02648","reference_uniquename":"PMID:29761456"}],"product":"Mannose-6-phosphate isomerase; catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000805","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER003C"}


id: YER004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMP52","product":"Protein of unknown function; localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation","secondary_identifier":"SGD:S000000806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER004W"}


id: YER005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03676":null,"YER005W":null},"has_protein_features":false,"name":"YND1","ortholog_annotations":[{"gene_uniquename":"YER005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03676","reference_uniquename":"PMID:29761456"}],"product":"Apyrase with wide substrate specificity; helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER005W"}


id: YER006C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PAC2/YER007W","secondary_identifier":"SGD:S000028745","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER006C-A"}


id: YER006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04004":null,"YER006W":null},"has_protein_features":false,"name":"NUG1","ortholog_annotations":[{"gene_uniquename":"YER006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04004","reference_uniquename":"PMID:29761456"}],"product":"GTPase that associates with nuclear 60S pre-ribosomes; required for export of 60S ribosomal subunits from the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER006W"}


id: YER007C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00912":null,"YER007C-A":null},"has_protein_features":false,"name":"TMA20","ortholog_annotations":[{"gene_uniquename":"YER007C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00912","reference_uniquename":"PMID:29761456"}],"product":"Ribosome-associated protein; involved along with heterodimeric partner Tma22p in recycling of 40S ribosomal subunits; involved in nonsense-mediated mRNA decay (NMD); contains a putative RNA binding domain; null mutant exhibits translation defects; localizes to the cytosol; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002957","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER007C-A"}


id: YER007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02672":null,"YER007W":null},"has_protein_features":false,"name":"PAC2","ortholog_annotations":[{"gene_uniquename":"YER007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02672","reference_uniquename":"PMID:29761456"}],"product":"Microtubule effector required for tubulin heterodimer formation; binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000809","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER007W"}


id: YER008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02166":null,"YER008C":null},"has_protein_features":false,"name":"SEC3","ortholog_annotations":[{"gene_uniquename":"YER008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02166","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000810","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER008C"}


id: YER009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02425":null,"YER009W":null},"has_protein_features":false,"name":"NTF2","ortholog_annotations":[{"gene_uniquename":"YER009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02425","reference_uniquename":"PMID:29761456"}],"product":"Nuclear envelope protein; interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER009W"}


id: YER010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Bifunctional HMG aldolase/oxaloacetate decarboxylase; requires divalent metal ions for activity; competitively inhibited by oxalate; forms a ring-shaped homotrimer; similar to members of the prokaryotic RraA family of class II (divalent metal ion dependent) pyruvate aldolases from the meta cleavage pathways of protocatechuate and gallate","secondary_identifier":"SGD:S000000812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER010C"}


id: YER011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TIR1","product":"Cell wall mannoprotein; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking; member of the Srp1p/Tip1p family of serine-alanine-rich proteins","secondary_identifier":"SGD:S000000813","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER011W"}


id: YER012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04888":null,"YER012W":null},"has_protein_features":false,"name":"PRE1","ortholog_annotations":[{"gene_uniquename":"YER012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04888","reference_uniquename":"PMID:29761456"}],"product":"Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000814","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER012W"}


id: YER013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05025":null,"YER013W":null},"has_protein_features":false,"name":"PRP22","ortholog_annotations":[{"gene_uniquename":"YER013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05025","reference_uniquename":"PMID:29761456"}],"product":"DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase; associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes; required for proofreading the exon ligation reaction","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000815","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER013W"}


id: YER014C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUD25","product":"Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern","secondary_identifier":"SGD:S000007590","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER014C-A"}


id: YER014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02876":null,"YER014W":null},"has_protein_features":false,"name":"HEM14","ortholog_annotations":[{"gene_uniquename":"YER014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02876","reference_uniquename":"PMID:29761456"}],"product":"Protoporphyrinogen oxidase; a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000816","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER014W"}


id: YER015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FAA2","product":"Medium chain fatty acyl-CoA synthetase; activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon","secondary_identifier":"SGD:S000000817","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER015W"}


id: YER016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02045":null,"YER016W":null},"has_protein_features":false,"name":"BIM1","ortholog_annotations":[{"gene_uniquename":"YER016W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02045","reference_uniquename":"PMID:29761456"}],"product":"Microtubule plus end-tracking protein; forms a complex with Kar9p that makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally; homolog of human end binding protein 1 (EB1)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000818","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER016W"}


id: YER017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01179":null,"YER017C":null},"has_protein_features":false,"name":"AFG3","ortholog_annotations":[{"gene_uniquename":"YER017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01179","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging; expression of human homolog AFG3L2 can complement yeast yta12 afg3 double mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000819","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER017C"}


id: YER018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03683":null,"YER018C":null},"has_protein_features":false,"name":"SPC25","ortholog_annotations":[{"gene_uniquename":"YER018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03683","reference_uniquename":"PMID:29761456"}],"product":"Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000820","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER018C"}


id: YER019C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00064":null,"YER019C-A":null},"has_protein_features":false,"name":"SBH2","ortholog_annotations":[{"gene_uniquename":"YER019C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00064","reference_uniquename":"PMID:29761456"}],"product":"Ssh1p-Sss1p-Sbh2p complex component; involved in protein translocation into the endoplasmic reticulum; SBH2 has a paralog, SBH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002127","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER019C-A"}


id: YER019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01219":null,"YER019W":null},"has_protein_features":false,"name":"ISC1","ortholog_annotations":[{"gene_uniquename":"YER019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01219","reference_uniquename":"PMID:29761456"}],"product":"Inositol phosphosphingolipid phospholipase C; hydrolyzes complex sphingolipids to produce ceramide; regulates the spindle assembly checkpoint upstream of PP2A-Cdc55; activates genes required for non-fermentable carbon source metabolism during the diauxic shift; mediates Na+ and Li+ halotolerance; activated by phosphatidylserine, cardiolipin and phosphatidylglycerol; mitochondrial outer membrane protein; ortholog of mammalian neutral sphingomyelinase type 2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000821","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER019W"}


id: YER020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02444":null,"YER020W":null},"has_protein_features":false,"name":"GPA2","ortholog_annotations":[{"gene_uniquename":"YER020W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02444","reference_uniquename":"PMID:29761456"}],"product":"Nucleotide binding alpha subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p, has signaling role in response to nutrients; required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000822","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER020W"}


id: YER021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04572":null,"YER021W":null},"has_protein_features":false,"name":"RPN3","ortholog_annotations":[{"gene_uniquename":"YER021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04572","reference_uniquename":"PMID:29761456"}],"product":"Essential non-ATPase regulatory subunit of the 26S proteasome lid; similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000823","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER021W"}


id: YER022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00904":null,"YER022W":null},"has_protein_features":false,"name":"SRB4","ortholog_annotations":[{"gene_uniquename":"YER022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00904","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for basal RNA polymerase II transcription; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000824","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER022W"}


id: YER023C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene PRO3; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028622","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER023C-A"}


id: YER023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00120":null,"YER023W":null},"has_protein_features":false,"name":"PRO3","ortholog_annotations":[{"gene_uniquename":"YER023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00120","reference_uniquename":"PMID:29761456"}],"product":"Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000825","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER023W"}


id: YER024W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YAT2","product":"Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane","secondary_identifier":"SGD:S000000826","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER024W"}


id: YER025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00466":null,"YER025W":null},"has_protein_features":false,"name":"GCD11","ortholog_annotations":[{"gene_uniquename":"YER025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00466","reference_uniquename":"PMID:29761456"}],"product":"Gamma subunit of the translation initiation factor eIF2; involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; mutations in human ortholog cause X-linked intellectual disability (XLID) syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000827","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER025W"}


id: YER026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01233":null,"YER026C":null},"has_protein_features":false,"name":"CHO1","ortholog_annotations":[{"gene_uniquename":"YER026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01233","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylserine synthase; functions in phospholipid biosynthesis; transcriptionally repressed by myo-inositol and choline","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000828","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER026C"}


id: YER027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03802":null,"YER027C":null},"has_protein_features":false,"name":"GAL83","ortholog_annotations":[{"gene_uniquename":"YER027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03802","reference_uniquename":"PMID:29761456"}],"product":"One of three alternate beta-subunits of the Snf1 kinase complex; allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; necessary and sufficient for phosphorylation of the Mig2p transcription factor in response to alkaline stress; functionally redundant with SIP1 and SIP2 for the phosphorylation of Mig1p in response to glucose deprivation; contains a glycogen-binding domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000829","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER027C"}


id: YER028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03473":null,"SJAG_03911":null,"YER028C":null},"has_protein_features":false,"name":"MIG3","ortholog_annotations":[{"gene_uniquename":"YER028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03473","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03911","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000830","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER028C"}


id: YER029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02279":null,"YER029C":null},"has_protein_features":false,"name":"SMB1","ortholog_annotations":[{"gene_uniquename":"YER029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02279","reference_uniquename":"PMID:29761456"}],"product":"Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000831","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER029C"}


id: YER030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02035":null,"YER030W":null},"has_protein_features":false,"name":"CHZ1","ortholog_annotations":[{"gene_uniquename":"YER030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02035","reference_uniquename":"PMID:29761456"}],"product":"Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000832","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER030W"}


id: YER031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03915":null,"YER031C":null},"has_protein_features":false,"name":"YPT31","ortholog_annotations":[{"gene_uniquename":"YER031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03915","reference_uniquename":"PMID:29761456"}],"product":"Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication; localizes to the transitional and late Golgi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000833","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER031C"}


id: YER032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FIR1","product":"Protein involved in 3' mRNA processing; interacts with Ref2p; APCC(Cdh1) substrate; potential Cdc28p substrate","secondary_identifier":"SGD:S000000834","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER032W"}


id: YER033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ZRG8","product":"Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency","secondary_identifier":"SGD:S000000835","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER033C"}


id: YER034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000000836","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER034W"}


id: YER035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01746":null,"YER035W":null},"has_protein_features":false,"name":"EDC2","ortholog_annotations":[{"gene_uniquename":"YER035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01746","reference_uniquename":"PMID:29761456"}],"product":"RNA-binding protein that directly activates mRNA decapping; binds mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein increases in abundance and relocalizes to nucleolus and to nuclear foci upon DNA replication stress; EDC2 has a paralog, EDC1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000837","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER035W"}


id: YER036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00599":null,"YER036C":null},"has_protein_features":false,"name":"ARB1","ortholog_annotations":[{"gene_uniquename":"YER036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00599","reference_uniquename":"PMID:29761456"}],"product":"ATPase of the ATP-binding cassette (ABC) family; involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; important for disaggregation of ordered and disordered aggregates; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p; human homolog ABCF2 can complement yeast ARB1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000838","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER036C"}


id: YER037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02593":null,"YER037W":null},"has_protein_features":false,"name":"PHM8","ortholog_annotations":[{"gene_uniquename":"YER037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02593","reference_uniquename":"PMID:29761456"}],"product":"Lysophosphatidic acid (LPA) phosphatase, nucleotidase; principle and physiological nucleotidase working on GMP, UMP and CMP; involved in LPA hydrolysis in response to phosphate starvation and ribose salvage pathway; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p; repressed by Gcn4p under normal conditions; PHM8 has a paralog, SDT1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000839","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER037W"}


id: YER038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00213":null,"YER038C":null},"has_protein_features":false,"name":"KRE29","ortholog_annotations":[{"gene_uniquename":"YER038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00213","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000840","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER038C"}


id: YER038W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMP49","product":"Mitochondrial protein of unknown function; almost completely overlaps ORF HVG1/YER039C","secondary_identifier":"SGD:S000028746","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER038W-A"}


id: YER039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00339":null,"YER039C":null},"has_protein_features":false,"name":"HVG1","ortholog_annotations":[{"gene_uniquename":"YER039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00339","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; HVG1 has a paralog, VRG4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000841","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER039C"}


id: YER039C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00339":null,"YER039C-A":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YER039C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00339","reference_uniquename":"PMID:26896847"}],"product":"Putative protein of unknown function; YER039C-A is not an essential gene","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000007226","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER039C-A"}


id: YER040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02730":null,"YER040W":null},"has_protein_features":false,"name":"GLN3","ortholog_annotations":[{"gene_uniquename":"YER040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02730","reference_uniquename":"PMID:26896847"}],"product":"Transcriptional activator in nitrogen catabolite repression system; localization and activity regulated by quality of nitrogen source and Ure2p; full-length protein forms prion-like aggregates when overproduced","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000000842","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER040W"}


id: YER041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YEN1","product":"Holliday junction resolvase; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1; similar to S. cerevisiae endonuclease Rth1p","secondary_identifier":"SGD:S000000843","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER041W"}


id: YER042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00419":null,"YER042W":null},"has_protein_features":false,"name":"MXR1","ortholog_annotations":[{"gene_uniquename":"YER042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00419","reference_uniquename":"PMID:29761456"}],"product":"Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; reduced activity of human homolog implicated in Alzheimer disease","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000844","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER042W"}


id: YER043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03556":null,"YER043C":null},"has_protein_features":false,"name":"SAH1","ortholog_annotations":[{"gene_uniquename":"YER043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03556","reference_uniquename":"PMID:29761456"}],"product":"S-adenosyl-L-homocysteine hydrolase; catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor; regulates cellular lipid homoeostasis by regulating phosphatidylcholine(PC)synthesis and triacylglycerol (TG) levels","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000845","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER043C"}


id: YER044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00453":null,"YER044C":null},"has_protein_features":false,"name":"ERG28","ortholog_annotations":[{"gene_uniquename":"YER044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00453","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum membrane protein; may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000846","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER044C"}


id: YER044C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02490":null,"YER044C-A":null},"has_protein_features":false,"name":"MEI4","ortholog_annotations":[{"gene_uniquename":"YER044C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02490","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein involved in forming DSBs; involved in double-strand break (DSBs) formation during meiotic recombination; required for chromosome synapsis and production of viable spores","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001954","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER044C-A"}


id: YER045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ACA1","product":"ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000847","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER045C"}


id: YER046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00974":null,"YER046W":null},"has_protein_features":false,"name":"SPO73","ortholog_annotations":[{"gene_uniquename":"YER046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00974","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific protein required for prospore membrane morphogenesis; required for the proper shape of the prospore membrane (PSM) and for spore wall formation; functions cooperatively with SPO71 in PSM elongation; physically interacts with Spo71p; genetically antagonistic to SPO1, similar to SPO71; localizes to the PSM; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; dysferlin domain-only protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000848","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER046W"}


id: YER046W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SAP1/YER047C","secondary_identifier":"SGD:S000028747","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER046W-A"}


id: YER047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01530":null,"SJAG_04566":null,"YER047C":null},"has_protein_features":false,"name":"SAP1","ortholog_annotations":[{"gene_uniquename":"YER047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01530","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04566","reference_uniquename":"PMID:29761456"}],"product":"Putative ATPase of the AAA family; interacts with the Sin1p transcriptional repressor in the two-hybrid system","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000849","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER047C"}


id: YER048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02034":null,"SJAG_02797":null,"YER048C":null},"has_protein_features":false,"name":"CAJ1","ortholog_annotations":[{"gene_uniquename":"YER048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02797","reference_uniquename":"PMID:29761456"}],"product":"Nuclear type II J heat shock protein of the E. coli dnaJ family; overexpression stabilizes amino acid permeases; contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly; localizes to the cytosol and plasma membrane, while a GFP fusion protein localizes to the nucleus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000850","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER048C"}


id: YER048W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00894":null,"YER048W-A":null},"has_protein_features":false,"name":"ISD11","ortholog_annotations":[{"gene_uniquename":"YER048W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00894","reference_uniquename":"PMID:29761456"}],"product":"Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis; exclusive to eukaryotes, implicated as eukaryotic supplement to the bacterium-derived Fe-S cluster (ISC) assembly apparatus; involved in regulation of iron metabolism; member of the LYR protein family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007237","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER048W-A"}


id: YER049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00642":null,"YER049W":null},"has_protein_features":false,"name":"TPA1","ortholog_annotations":[{"gene_uniquename":"YER049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00642","reference_uniquename":"PMID:29761456"}],"product":"Prolyl hydroxylase; catalyzes oxygen-dependent dihydroxylation of Rps23a/b, a 40S ribosomal decoding center subunit; influences translational termination and regulates translational accuracy; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; disputed role as a oxidative dealkylase repairing DNA methyl-base lesions; poly(rA)-binding protein affecting poly(A) tail length and mRNA stability; Fe(II)/2-oxoglutarate-dependent dioxygenase family member similar to human prolyl 4-hydroxylase OGFOD1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000851","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER049W"}


id: YER050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04281":null,"YER050C":null},"has_protein_features":false,"name":"RSM18","ortholog_annotations":[{"gene_uniquename":"YER050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04281","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S18 ribosomal protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000852","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER050C"}


id: YER051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03664":null,"YER051W":null},"has_protein_features":false,"name":"JHD1","ortholog_annotations":[{"gene_uniquename":"YER051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03664","reference_uniquename":"PMID:29761456"}],"product":"JmjC domain family histone demethylase specific for H3-K36; similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000853","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER051W"}


id: YER052C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00881":null,"YER052C":null},"has_protein_features":false,"name":"HOM3","ortholog_annotations":[{"gene_uniquename":"YER052C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00881","reference_uniquename":"PMID:29761456"}],"product":"Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; subject to allosteric feedback inhibition by threonine; expression regulated by Gcn4p and the general control of amino acid synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000854","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER052C"}


id: YER053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00547":null,"YER053C":null},"has_protein_features":false,"name":"PIC2","ortholog_annotations":[{"gene_uniquename":"YER053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00547","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial copper and phosphate carrier; imports copper and inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000855","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER053C"}


id: YER053C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000007523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER053C-A"}


id: YER054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GIP2","product":"Putative regulatory subunit of protein phosphatase Glc7p; involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p; GIP2 has a paralog, PIG2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000856","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER054C"}


id: YER055C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04747":null,"YER055C":null},"has_protein_features":false,"name":"HIS1","ortholog_annotations":[{"gene_uniquename":"YER055C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04747","reference_uniquename":"PMID:29761456"}],"product":"ATP phosphoribosyltransferase; a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000857","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER055C"}


id: YER056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FCY2","product":"Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress","secondary_identifier":"SGD:S000000858","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER056C"}


id: YER056C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01853":null,"SJAG_05216":null,"YER056C-A":null},"has_protein_features":false,"name":"RPL34A","ortholog_annotations":[{"gene_uniquename":"YER056C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01853","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER056C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05216","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002135","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER056C-A"}


id: YER057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00107":null,"YER057C":null},"has_protein_features":false,"name":"HMF1","ortholog_annotations":[{"gene_uniquename":"YER057C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00107","reference_uniquename":"PMID:29761456"}],"product":"Member of the p14.5 protein family; functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro; HMF1 has a paralog, MMF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000859","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER057C"}


id: YER058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00852":null,"YER058W":null},"has_protein_features":false,"name":"PET117","ortholog_annotations":[{"gene_uniquename":"YER058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00852","reference_uniquename":"PMID:29761456"}],"product":"Assembly factor that couples heme a synthesis to complex IV assembly; regulates the oligomerization state of the Cox15p heme a synthase, and couples this to the assembly of the cytochrome C oxidase complex (complex IV)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000860","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER058W"}


id: YER059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05978":null,"YER059W":null},"has_protein_features":false,"name":"PCL6","ortholog_annotations":[{"gene_uniquename":"YER059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05978","reference_uniquename":"PMID:29761456"}],"product":"Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding; PCL6 has a paralog, PCL7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000861","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER059W"}


id: YER060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FCY21","product":"Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function","secondary_identifier":"SGD:S000000862","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER060W"}


id: YER060W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FCY22","product":"Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function","secondary_identifier":"SGD:S000002958","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER060W-A"}


id: YER061C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01946":null,"YER061C":null},"has_protein_features":false,"name":"CEM1","ortholog_annotations":[{"gene_uniquename":"YER061C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01946","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial beta-keto-acyl synthase; possible role in fatty acid synthesis; required for mitochondrial respiration; human homolog OXSM can complement yeast cem1 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000863","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER061C"}


id: YER062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GPP2","product":"DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis; also known as glycerol-1-phosphatase; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; GPP2 has a paralog, GPP1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000864","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER062C"}


id: YER063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02534":null,"YER063W":null},"has_protein_features":false,"name":"THO1","ortholog_annotations":[{"gene_uniquename":"YER063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02534","reference_uniquename":"PMID:29761456"}],"product":"Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000865","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER063W"}


id: YER064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VHR2","product":"Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000000866","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER064C"}


id: YER065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ICL1","product":"Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose","secondary_identifier":"SGD:S000000867","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER065C"}


id: YER066C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YER067W","secondary_identifier":"SGD:S000002959","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER066C-A"}


id: YER066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRT13","product":"Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription","secondary_identifier":"SGD:S000000868","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER066W"}


id: YER067C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF RGI1/YER067W","secondary_identifier":"SGD:S000028748","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER067C-A"}


id: YER067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RGI1","product":"Protein involved in energy metabolism under respiratory conditions; abundance is increased upon intracellular iron depletion or in response to DNA replication stress; suppresses pro-apoptotic effect of expressing human BAX in yeast cells; RGI1 has a paralog, RGI2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000869","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER067W"}


id: YER068C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF ARG5,6/YER069W","secondary_identifier":"SGD:S000028749","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER068C-A"}


id: YER068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03883":null,"YER068W":null},"has_protein_features":false,"name":"MOT2","ortholog_annotations":[{"gene_uniquename":"YER068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03883","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000870","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER068W"}


id: YER069W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00636":null,"YER069W":null},"has_protein_features":false,"name":"ARG56","ortholog_annotations":[{"gene_uniquename":"YER069W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00636","reference_uniquename":"PMID:29761456"}],"product":"Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000871","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER069W"}


id: YER070W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04665":null,"YER070W":null},"has_protein_features":false,"name":"RNR1","ortholog_annotations":[{"gene_uniquename":"YER070W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04665","reference_uniquename":"PMID:29761456"}],"product":"Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; relative distribution to the nucleus increases upon DNA replication stress; RNR1 has a paralog, RNR3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000872","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER070W"}


id: YER071C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01370":null,"YER071C":null},"has_protein_features":false,"name":"TDA2","ortholog_annotations":[{"gene_uniquename":"YER071C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01370","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a complex that associates with actin filaments; forms a complex with Aim21p that inhibits barbed end F-actin assembly; elevates actin monomer pools to increase endocytotic efficiency and to regulate the distribution of actin between cables and patches; Aim21p/Tda2p forms a larger complex with actin capping proteins Cap1p and Cap2p; TcTex1-type dynein light chain family member; null mutant is sensitive to expression of the top1-T722A allele","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000873","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER071C"}


id: YER072W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01319":null,"YER072W":null},"has_protein_features":false,"name":"VTC1","ortholog_annotations":[{"gene_uniquename":"YER072W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01319","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; important regulator of substrate invagination from the vacuolar membrane; also binds mRNA; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000874","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER072W"}


id: YER073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03786":null,"YER073W":null},"has_protein_features":false,"name":"ALD5","ortholog_annotations":[{"gene_uniquename":"YER073W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03786","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial aldehyde dehydrogenase; involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000875","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER073W"}


id: YER074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00468":null,"SJAG_02585":null,"YER074W":null},"has_protein_features":false,"name":"RPS24A","ortholog_annotations":[{"gene_uniquename":"YER074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00468","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02585","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000876","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER074W"}


id: YER074W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05013":null,"YER074W-A":null},"has_protein_features":false,"name":"YOS1","ortholog_annotations":[{"gene_uniquename":"YER074W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05013","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER074W-A"}


id: YER075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02000":null,"SJAG_02013":null,"YER075C":null},"has_protein_features":false,"name":"PTP3","ortholog_annotations":[{"gene_uniquename":"YER075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02000","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER075C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02013","reference_uniquename":"PMID:29761456"}],"product":"Phosphotyrosine-specific protein phosphatase; major role in the pheromone adaptive response through dephosphorylation of the Fus3p MAPK with a minor role by Ptp2p and Msg5p; minor role in the inactivation of Hog1p MAPK during osmolarity sensing with major role by Ptp2p; dephosphorylates and regulates the localization of Hog1p; minor role in the cell wall integrity pathway through tyrosine dephosphorylation of the MAPK Slt2p while Ptp2p plays a major role; localizes to the cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000877","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER075C"}


id: YER076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization","secondary_identifier":"SGD:S000000878","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER076C"}


id: YER076W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER076C","secondary_identifier":"SGD:S000028750","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER076W-A"}


id: YER077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRX1","product":"Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport","secondary_identifier":"SGD:S000000879","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER077C"}


id: YER078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01896":null,"YER078C":null},"has_protein_features":false,"name":"ICP55","ortholog_annotations":[{"gene_uniquename":"YER078C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01896","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial aminopeptidase; cleaves N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of aminopeptidase P family; exists in rapid equilibrium between monomer and dimer, with dimer being active species; ortholog of human gene XPNPEP3, which is mutated in rare hereditary kidney disease similar to nephronophthisis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000880","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER078C"}


id: YER078W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028546","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER078W-A"}


id: YER079C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF AIM9/YER080W","secondary_identifier":"SGD:S000028751","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER079C-A"}


id: YER079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000000881","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER079W"}


id: YER080W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM9","product":"Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss","secondary_identifier":"SGD:S000000882","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER080W"}


id: YER081W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02313":null,"YER081W":null},"has_protein_features":false,"name":"SER3","ortholog_annotations":[{"gene_uniquename":"YER081W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02313","reference_uniquename":"PMID:29761456"}],"product":"3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); directly phosphorylated by TORC1 in a Pib2-dependent manner; localizes to the cytoplasm; ER3 has a paralog, SER33, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000883","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER081W"}


id: YER082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04908":null,"YER082C":null},"has_protein_features":false,"name":"UTP7","ortholog_annotations":[{"gene_uniquename":"YER082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04908","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000884","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER082C"}


id: YER083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01940":null,"YER083C":null},"has_protein_features":false,"name":"GET2","ortholog_annotations":[{"gene_uniquename":"YER083C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01940","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the GET complex; involved in insertion of  tail-anchored proteins proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division; Get1p and Get2p form an aqueous channel for protein translocation and insertion into the membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000885","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER083C"}


id: YER084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; expressed at both mRNA and protein levels","secondary_identifier":"SGD:S000000886","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER084W"}


id: YER084W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps uncharacterized ORF YER085C","secondary_identifier":"SGD:S000028752","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER084W-A"}


id: YER085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000000887","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER085C"}


id: YER086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00830":null,"YER086W":null},"has_protein_features":false,"name":"ILV1","ortholog_annotations":[{"gene_uniquename":"YER086W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00830","reference_uniquename":"PMID:29761456"}],"product":"Threonine deaminase, catalyzes first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000888","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER086W"}


id: YER087C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF AIM10/YER087W","secondary_identifier":"SGD:S000028753","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER087C-A"}


id: YER087C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00064":null,"YER087C-B":null},"has_protein_features":false,"name":"SBH1","ortholog_annotations":[{"gene_uniquename":"YER087C-B","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00064","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; cotranslationally N-acetylated by NatA; SBH1 has a paralog, SBH2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002128","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER087C-B"}


id: YER087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02236":null,"YER087W":null},"has_protein_features":false,"name":"AIM10","ortholog_annotations":[{"gene_uniquename":"YER087W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02236","reference_uniquename":"PMID:29761456"}],"product":"Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000889","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER087W"}


id: YER088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DOT6","product":"Protein involved in rRNA and ribosome biogenesis; activated in stochastic pulses of nuclear localization; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000000890","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER088C"}


id: YER088C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORFs PTC2/YER089C and YER088W-B","secondary_identifier":"SGD:S000028754","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER088C-A"}


id: YER088W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the ORF PTC2/YER089C; identified by gene-trapping, expression analysis, and homology searching","secondary_identifier":"SGD:S000028623","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER088W-B"}


id: YER089C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03482":null,"SJAG_03893":null,"YER089C":null},"has_protein_features":false,"name":"PTC2","ortholog_annotations":[{"gene_uniquename":"YER089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03482","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER089C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03893","reference_uniquename":"PMID:29761456"}],"product":"Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000891","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER089C"}


id: YER090C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000029725","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER090C-A"}


id: YER090W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02505":null,"YER090W":null},"has_protein_features":false,"name":"TRP2","ortholog_annotations":[{"gene_uniquename":"YER090W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02505","reference_uniquename":"PMID:29761456"}],"product":"Anthranilate synthase; catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000892","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER090W"}


id: YER091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02290":null,"YER091C":null},"has_protein_features":false,"name":"MET6","ortholog_annotations":[{"gene_uniquename":"YER091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02290","reference_uniquename":"PMID:29761456"}],"product":"Cobalamin-independent methionine synthase; involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000893","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER091C"}


id: YER091C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007238","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER091C-A"}


id: YER092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IES5","product":"Non-essential INO80 chromatin remodeling complex subunit; deletion affects telomere maintenance via recombination","secondary_identifier":"SGD:S000000894","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER092W"}


id: YER093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04460":null,"YER093C":null},"has_protein_features":false,"name":"TSC11","ortholog_annotations":[{"gene_uniquename":"YER093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04460","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; contains an N-terminal armadillo repeat region necessary for recruitment to the PM and for anchoring Tor2p and Avo1p at the PM; acts along with Avo1p as a scaffold important for integrity of the TORC2 complex; involved in sphingolipid metabolism; contains a RasGEFN domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000895","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER093C"}


id: YER093C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04460":null,"YER093C-A":null},"has_protein_features":false,"name":"AIM11","ortholog_annotations":[{"gene_uniquename":"YER093C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04460","reference_uniquename":"PMID:26896847"}],"product":"Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; localizes to the peroxisome in glucose; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000002960","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER093C-A"}


id: YER094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04229":null,"YER094C":null},"has_protein_features":false,"name":"PUP3","ortholog_annotations":[{"gene_uniquename":"YER094C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04229","reference_uniquename":"PMID:29761456"}],"product":"Beta 3 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit C10","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000896","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER094C"}


id: YER095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01410":null,"YER095W":null},"has_protein_features":false,"name":"RAD51","ortholog_annotations":[{"gene_uniquename":"YER095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01410","reference_uniquename":"PMID:29761456"}],"product":"Strand exchange protein; forms helical filament with DNA that searches for homology; involved in recombinational repair of DNA DSBs during vegetative growth and meiosis; phosphorylation by Cdc28p in G2/M phase promotes DNA binding, strand invasion, and primer extension; L1 and L2 motifs of DNA binding site I have critical roles in ensuring DNA fidelity during meiotic recombination; RAD51 and RAD4 pathways confer resistance to benzo[a]pyrene dihydrodiol; homolog of Dmc1p and bacterial RecA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000897","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER095W"}


id: YER096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02733":null,"SJAG_04595":null,"YER096W":null},"has_protein_features":false,"name":"SHC1","ortholog_annotations":[{"gene_uniquename":"YER096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02733","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04595","reference_uniquename":"PMID:29761456"}],"product":"Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000898","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER096W"}


id: YER097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000000899","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER097W"}


id: YER098W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00546":null,"YER098W":null},"has_protein_features":false,"name":"UBP9","ortholog_annotations":[{"gene_uniquename":"YER098W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00546","reference_uniquename":"PMID:29761456"}],"product":"Putative ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000900","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER098W"}


id: YER099C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03811":null,"YER099C":null},"has_protein_features":false,"name":"PRS2","ortholog_annotations":[{"gene_uniquename":"YER099C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03811","reference_uniquename":"PMID:29761456"}],"product":"5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000901","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER099C"}


id: YER100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05022":null,"YER100W":null},"has_protein_features":false,"name":"UBC6","ortholog_annotations":[{"gene_uniquename":"YER100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05022","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-conjugating enzyme involved in ERAD; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway; ER-associated protein degradation is also known as ERAD","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000902","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER100W"}


id: YER101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AST2","product":"Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000903","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER101C"}


id: YER102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02020":null,"SJAG_04029":null,"YER102W":null},"has_protein_features":false,"name":"RPS8B","ortholog_annotations":[{"gene_uniquename":"YER102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02020","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04029","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8B has a paralog, RPS8A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000904","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER102W"}


id: YER103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01186":null,"SJAG_04055":null,"YER103W":null},"has_protein_features":false,"name":"SSA4","ortholog_annotations":[{"gene_uniquename":"YER103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01186","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04055","reference_uniquename":"PMID:29761456"}],"product":"Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000905","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER103W"}


id: YER104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RTT105","product":"Chaperone for Replication Protein A complex (RPA); involved in nuclear import of RPA and its binding to ssDNA at replication forks; has a role in regulation of Ty1 transposition","secondary_identifier":"SGD:S000000906","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER104W"}


id: YER105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02757":null,"YER105C":null},"has_protein_features":false,"name":"NUP157","ortholog_annotations":[{"gene_uniquename":"YER105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02757","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000907","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER105C"}


id: YER106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MAM1","product":"Monopolin; meiosis-specific kinetochore-associated protein involved in monopolar attachment of sister kinetochores to the meiotic spindle; subunit of monopolin, a complex that prevents biorientation of sister kinetochores to ensure homolog biorientation during meiosis I; regulates the conformation, enzyme kinetics and substrate specificity of the Dsn1p kinase, Hrr1p; expressed only during the first meiotic division","secondary_identifier":"SGD:S000000908","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER106W"}


id: YER107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04379":null,"YER107C":null},"has_protein_features":false,"name":"GLE2","ortholog_annotations":[{"gene_uniquename":"YER107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04379","reference_uniquename":"PMID:29761456"}],"product":"RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000909","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER107C"}


id: YER107W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF GLE2/YER107C","secondary_identifier":"SGD:S000028755","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER107W-A"}


id: YER108C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged ORF; YER108C has been merged into YER109C because it has been demonstrated that they correspond to a mutated FLO8 gene with an A to G transition at position 431 in strain S288C, changing amino acid 144 from a Trp to a stop","secondary_identifier":"SGD:S000117700","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER108C"}


id: YER109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01441":null,"SJAG_04421":null,"YER109C":null},"has_protein_features":false,"name":"FLO8","ortholog_annotations":[{"gene_uniquename":"YER109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01441","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04421","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor; required for flocculation, diploid filamentous growth, and haploid invasive growth; forms a heterodimer with Mss11p that interacts with the Swi/Snf complex during transcriptional activation of FLO1, FLO11, and STA1; S. cerevisiae genome reference strain S288C contains an internal in-frame stop at codon 142, which in other strains encodes tryptophan","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000911","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER109C"}


id: YER110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03662":null,"YER110C":null},"has_protein_features":false,"name":"KAP123","ortholog_annotations":[{"gene_uniquename":"YER110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03662","reference_uniquename":"PMID:29761456"}],"product":"Karyopherin beta; mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000912","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER110C"}


id: YER111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00693":null,"YER111C":null},"has_protein_features":false,"name":"SWI4","ortholog_annotations":[{"gene_uniquename":"YER111C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00693","reference_uniquename":"PMID:29761456"}],"product":"DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; Slt2p-independent regulator of cold growth; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000913","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER111C"}


id: YER112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03070":null,"YER112W":null},"has_protein_features":false,"name":"LSM4","ortholog_annotations":[{"gene_uniquename":"YER112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03070","reference_uniquename":"PMID:29761456"}],"product":"Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000914","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER112W"}


id: YER113C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TMN3","product":"Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation","secondary_identifier":"SGD:S000000915","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER113C"}


id: YER114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01448":null,"YER114C":null},"has_protein_features":false,"name":"BOI2","ortholog_annotations":[{"gene_uniquename":"YER114C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01448","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in polar growth; functionally redundant with Boi1p; required for fusion of secretory vesicles with plasma membrane at sites of polarized growth and for inhibition of membrane abscission until the end of cytokinesis; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI2 has a paralog, BOI1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000916","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER114C"}


id: YER115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPR6","product":"Protein of unknown function; expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation","secondary_identifier":"SGD:S000000917","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER115C"}


id: YER116C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02299":null,"YER116C":null},"has_protein_features":false,"name":"SLX8","ortholog_annotations":[{"gene_uniquename":"YER116C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02299","reference_uniquename":"PMID:29761456"}],"product":"Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; role in proteolysis of spindle positioning protein Kar9, DNA repair proteins Rad52p and Rad57p; stimulated by SUMO-modified substrates; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress; required for maintenance of genome integrity like human ortholog RNF4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000918","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER116C"}


id: YER117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01087":null,"SJAG_03197":null,"YER117W":null},"has_protein_features":false,"name":"RPL23B","ortholog_annotations":[{"gene_uniquename":"YER117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01087","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03197","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000919","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER117W"}


id: YER118C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SHO1","product":"Transmembrane osmosensor for filamentous growth and HOG pathways; involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol (HOG) response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p","secondary_identifier":"SGD:S000000920","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER118C"}


id: YER119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03256":null,"YER119C":null},"has_protein_features":false,"name":"AVT6","ortholog_annotations":[{"gene_uniquename":"YER119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03256","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000921","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER119C"}


id: YER119C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2","secondary_identifier":"SGD:S000002961","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER119C-A"}


id: YER120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00053":null,"SJAG_03170":null,"YER120W":null},"has_protein_features":false,"name":"SCS2","ortholog_annotations":[{"gene_uniquename":"YER120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00053","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER120W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03170","reference_uniquename":"PMID:29761456"}],"product":"Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to substrate PI4P in the PM; interacts with FFAT motifs in Opi1p, Swh1p, Osh2p, and Osh3p; involved in telomeric silencing; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000922","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER120W"}


id: YER121W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy","secondary_identifier":"SGD:S000000923","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER121W"}


id: YER122C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04391":null,"YER122C":null},"has_protein_features":false,"name":"GLO3","ortholog_annotations":[{"gene_uniquename":"YER122C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04391","reference_uniquename":"PMID:29761456"}],"product":"ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; shares functional similarity with Gcs1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000924","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER122C"}


id: YER123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00402":null,"SJAG_01373":null,"SJAG_03987":null,"YER123W":null},"has_protein_features":false,"name":"YCK3","ortholog_annotations":[{"gene_uniquename":"YER123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00402","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01373","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03987","reference_uniquename":"PMID:29761456"}],"product":"Palmitoylated vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; targeted to vacuole via AP-3 pathway; regulates vesicle fusion in AP-3 pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000925","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER123W"}


id: YER124C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DSE1","product":"Daughter cell-specific protein; may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000000926","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER124C"}


id: YER125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01360":null,"SJAG_03970":null,"SJAG_04600":null,"YER125W":null},"has_protein_features":false,"name":"RSP5","ortholog_annotations":[{"gene_uniquename":"YER125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01360","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03970","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04600","reference_uniquename":"PMID:29761456"}],"product":"NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p, Sem1p, Dip5p and Put4p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000927","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER125W"}


id: YER126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01811":null,"YER126C":null},"has_protein_features":false,"name":"NSA2","ortholog_annotations":[{"gene_uniquename":"YER126C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01811","reference_uniquename":"PMID:29761456"}],"product":"Protein constituent of 66S pre-ribosomal particles; contributes to processing of the 27S pre-rRNA; recruited by ribosomal proteins L17, L35, and L37 to assembling ribosomes after 27SB pre-rRNA is generated, immediately preceding removal of ITS2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000928","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER126C"}


id: YER127W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00294":null,"YER127W":null},"has_protein_features":false,"name":"LCP5","ortholog_annotations":[{"gene_uniquename":"YER127W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00294","reference_uniquename":"PMID:29761456"}],"product":"Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000929","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER127W"}


id: YER128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00777":null,"YER128W":null},"has_protein_features":false,"name":"VFA1","ortholog_annotations":[{"gene_uniquename":"YER128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00777","reference_uniquename":"PMID:29761456"}],"product":"Protein that interacts with Vps4p and has a role in vacuolar sorting; stimulates the ATPase activity of Vps4; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000930","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER128W"}


id: YER129W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03486":null,"YER129W":null},"has_protein_features":false,"name":"SAK1","ortholog_annotations":[{"gene_uniquename":"YER129W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03486","reference_uniquename":"PMID:29761456"}],"product":"Upstream serine/threonine kinase for the SNF1 complex; plays a role in pseudohyphal growth; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; SAK1 has a paralog, TOS3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000931","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER129W"}


id: YER130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03388":null,"YER130C":null},"has_protein_features":false,"name":"COM2","ortholog_annotations":[{"gene_uniquename":"YER130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03388","reference_uniquename":"PMID:29761456"}],"product":"Transcription factor that binds IME1 Upstream Activation Signal (UAS)ru; COM2 transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; may bind the IME1 promoter under all growth conditions to negatively regulate its transcription in the absence of a positive regulator that binds more effectively; repressor activity may depend on phosphorylation by PKA; C. albicans homolog (MNL1) plays a role in adaptation to stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000932","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER130C"}


id: YER131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01366":null,"SJAG_02894":null,"YER131W":null},"has_protein_features":false,"name":"RPS26B","ortholog_annotations":[{"gene_uniquename":"YER131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01366","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02894","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication; human homolog can partially complement an RPS26A, RPS26B double null mutant; mutations in the human gene are associated with Diamond-Blackfan anemia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000933","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER131W"}


id: YER132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PMD1","product":"Protein with an N-terminal kelch-like domain; putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions; PMD1 has a paralog, MDS3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000934","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER132C"}


id: YER133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02536":null,"SJAG_03126":null,"YER133W":null},"has_protein_features":false,"name":"GLC7","ortholog_annotations":[{"gene_uniquename":"YER133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02536","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03126","reference_uniquename":"PMID:29761456"}],"product":"Type 1 S/T protein phosphatase (PP1) catalytic subunit; involved in glycogen metabolism, sporulation and mitotic progression; interacts with multiple regulatory subunits; regulates actomyosin ring formation; subunit of CPF; recruited to mating projections by Afr1p interaction; regulates nucleocytoplasmic shuttling of Hxk2p; import into the nucleus is inhibited during spindle assembly checkpoint arrest; involved in dephosphorylating Rps6a/b and Bnr1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000935","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER133W"}


id: YER133W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF YER134C","secondary_identifier":"SGD:S000028756","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER133W-A"}


id: YER134C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02405":null,"YER134C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YER134C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02405","reference_uniquename":"PMID:29761456"}],"product":"Magnesium-dependent acid phosphatase; member of the haloacid dehalogenase superfamily; non-essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000936","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER134C"}


id: YER135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; YER135C is not an essential gene","secondary_identifier":"SGD:S000000937","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER135C"}


id: YER136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02422":null,"YER136W":null},"has_protein_features":false,"name":"GDI1","ortholog_annotations":[{"gene_uniquename":"YER136W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02422","reference_uniquename":"PMID:29761456"}],"product":"GDP dissociation inhibitor; regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000938","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER136W"}


id: YER137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function","secondary_identifier":"SGD:S000000939","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER137C"}


id: YER137W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF YER137C","secondary_identifier":"SGD:S000028757","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER137W-A"}


id: YER138W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YER138W-A has a paralog, YBL107W-A, that arose from a single-locus duplication","secondary_identifier":"SGD:S000007239","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER138W-A"}


id: YER139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02203":null,"YER139C":null},"has_protein_features":false,"name":"RTR1","ortholog_annotations":[{"gene_uniquename":"YER139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02203","reference_uniquename":"PMID:29761456"}],"product":"Dual specificity protein phosphatase; dephosphorylates T1 and S5 in  C-terminal domain (CTD) of RNA polymerase II largest subunit, Rpo21p; autoregulates turnover of its mRNA; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000941","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER139C"}


id: YER140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00893":null,"YER140W":null},"has_protein_features":false,"name":"EMP65","ortholog_annotations":[{"gene_uniquename":"YER140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00893","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane protein of the ER; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS3; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000942","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER140W"}


id: YER141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04397":null,"YER141W":null},"has_protein_features":false,"name":"COX15","ortholog_annotations":[{"gene_uniquename":"YER141W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04397","reference_uniquename":"PMID:29761456"}],"product":"Heme a synthase; required for the hydroxylation of heme O to form heme A, an essential prosthetic group for cytochrome c oxidase; oligomerization is required for function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000943","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER141W"}


id: YER142C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01971":null,"SJAG_05257":null,"YER142C":null},"has_protein_features":false,"name":"MAG1","ortholog_annotations":[{"gene_uniquename":"YER142C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01971","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER142C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05257","reference_uniquename":"PMID:29761456"}],"product":"3-methyl-adenine DNA glycosylase; initiates base excision repair (BER) by removing damaged bases to create abasic sites that are subsequently repaired; expansion of BER repair removes alkylated bases resulting from alkylating agent-induced DNA damage, compensating for the lack of DNA repair by oxidative dealkylation; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000944","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER142C"}


id: YER143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03763":null,"YER143W":null},"has_protein_features":false,"name":"DDI1","ortholog_annotations":[{"gene_uniquename":"YER143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03763","reference_uniquename":"PMID:29761456"}],"product":"Aspartic-type endopeptidase; involved in the cleavage of long-chain polyubiquitinated substrates; role in proteasome-independent, ubiquitin (Ub)-dependent proteolysis and DNA-protein crosslink repair; Ub-shuttle receptor for HO and Ufo1p; DNA damage-inducible v-SNARE binding protein and negative regulator of constitutive exocytosis; possible role in the S-phase checkpoint; UBL-UBA family member containing Ub-like (UBL), helical, Ub-associated (UBA) and retroviral-like proteinase (RVP) domains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000945","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER143W"}


id: YER144C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03429":null,"YER144C":null},"has_protein_features":false,"name":"UBP5","ortholog_annotations":[{"gene_uniquename":"YER144C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03429","reference_uniquename":"PMID:29761456"}],"product":"Putative ubiquitin-specific protease; concentrates at the bud neck; UBP5 has a paralog, DOA4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000946","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER144C"}


id: YER145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04675":null,"YER145C":null},"has_protein_features":false,"name":"FTR1","ortholog_annotations":[{"gene_uniquename":"YER145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04675","reference_uniquename":"PMID:29761456"}],"product":"High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000947","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER145C"}


id: YER145C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; overlaps verified ORF LSM5/YER146W","secondary_identifier":"SGD:S000028758","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER145C-A"}


id: YER146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01327":null,"YER146W":null},"has_protein_features":false,"name":"LSM5","ortholog_annotations":[{"gene_uniquename":"YER146W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01327","reference_uniquename":"PMID:29761456"}],"product":"Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000948","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER146W"}


id: YER147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00682":null,"YER147C":null},"has_protein_features":false,"name":"SCC4","ortholog_annotations":[{"gene_uniquename":"YER147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00682","reference_uniquename":"PMID:29761456"}],"product":"Subunit of cohesin loading factor (Scc2p-Scc4p); complex is required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000949","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER147C"}


id: YER147C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SPT15/YER148W","secondary_identifier":"SGD:S000028759","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER147C-A"}


id: YER148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00421":null,"YER148W":null},"has_protein_features":false,"name":"SPT15","ortholog_annotations":[{"gene_uniquename":"YER148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00421","reference_uniquename":"PMID:29761456"}],"product":"TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000950","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER148W"}


id: YER148W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF PEA2/YER149C","secondary_identifier":"SGD:S000028760","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER148W-A"}


id: YER149C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PEA2","product":"Coiled-coil 12S polarisome subunit; required for polarity establishment, apical bud growth, shmoo formation, filamentous differentiation; involved in Bni1p localization at sites of polarized growth, controlling polarized assembly of actin cables; role in apical growth affects diploid-specific bipolar bud site selection; retains Slt2p at bud tip to regulate ER inheritance; role in Ca2+ influx, cell fusion; S288C allele encoding Leu409 rather than Met linked with non-invasion","secondary_identifier":"SGD:S000000951","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER149C"}


id: YER150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPI1","product":"GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; SPI1 has a paralog, SED1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000952","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER150W"}


id: YER151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02419":null,"YER151C":null},"has_protein_features":false,"name":"UBP3","ortholog_annotations":[{"gene_uniquename":"YER151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02419","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-specific protease that cleaves Ub-protein fusions; interacts with cofactor Bre5p to regulate transport between ER and Golgi, deubiquitinating COPII and COPI proteins, Sec23p and Sec27p; mediates steady-state retention of Golgi membrane proteins with Bre5p; phosphorylation (S695) by Hog1p regulates transcriptional activation by osmostress; inhibits Ras/PKA signaling through Ira2p; inhibits silencing; role in ribophagy; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000953","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER151C"}


id: YER152C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04678":null,"YER152C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YER152C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04678","reference_uniquename":"PMID:26896847"}],"product":"Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000000954","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER152C"}


id: YER152W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF YER152C","secondary_identifier":"SGD:S000028761","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER152W-A"}


id: YER153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PET122","product":"Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane","secondary_identifier":"SGD:S000000955","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER153C"}


id: YER154W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03633":null,"SJAG_05300":null,"YER154W":null},"has_protein_features":false,"name":"OXA1","ortholog_annotations":[{"gene_uniquename":"YER154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03633","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER154W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05300","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane insertase; mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane; also has a role in insertion of carrier proteins into the inner membrane; acts as a voltage-gated ion channel, activated by substrate peptides; interacts with mitochondrial ribosomes; conserved from bacteria to animals","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000956","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER154W"}


id: YER155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BEM2","product":"Rho GTPase activating protein (RhoGAP); contains RhoGAP activity specific for both Rho1p and Cdc42p, and potentially Rho4p; acts with the RhoGAP Bem3p to negatively regulate Cdc42p-dependent signal transduction; involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence and for the morphogenesis checkpoint in response to actin depolymerization; localizes to sites of polarized growth and the plasma membrane","secondary_identifier":"SGD:S000000957","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER155C"}


id: YER156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01501":null,"YER156C":null},"has_protein_features":false,"name":"MYG1","ortholog_annotations":[{"gene_uniquename":"YER156C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01501","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in mitochondrial function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; role in preventing L-A mycovirus pathogenesis; human homolog MYG1 is linked to developmental processes and dermatological diseases, complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000958","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER156C"}


id: YER157W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01459":null,"YER157W":null},"has_protein_features":false,"name":"COG3","ortholog_annotations":[{"gene_uniquename":"YER157W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01459","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000959","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER157W"}


id: YER158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000000960","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER158C"}


id: YER158W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028624","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER158W-A"}


id: YER159C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00958":null,"YER159C":null},"has_protein_features":false,"name":"BUR6","ortholog_annotations":[{"gene_uniquename":"YER159C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00958","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000961","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER159C"}


id: YER161C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04257":null,"YER161C":null},"has_protein_features":false,"name":"SPT2","ortholog_annotations":[{"gene_uniquename":"YER161C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04257","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components; relocalizes to the cytosol in response to hypoxia; similar to mammalian HMG1 proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000963","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER161C"}


id: YER162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01049":null,"SJAG_01887":null,"YER162C":null},"has_protein_features":false,"name":"RAD4","ortholog_annotations":[{"gene_uniquename":"YER162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01049","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01887","reference_uniquename":"PMID:29761456"}],"product":"Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2; recognizes and binds damaged DNA with Rad23p during nucleotide excision repair (NER); also involved with Rad23p in turnover of ubiquitylated proteins; Rad4p-Rad23p heterodimer binds to promoters of DNA damage response genes to repress their transcription in the absence of DNA damage; RAD4 and RAD51 pathways confer resistance to benzo[a]pyrene dihydrodiol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000964","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER162C"}


id: YER163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00903":null,"YER163C":null},"has_protein_features":false,"name":"GCG1","ortholog_annotations":[{"gene_uniquename":"YER163C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00903","reference_uniquename":"PMID:29761456"}],"product":"Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000965","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER163C"}


id: YER164W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01653":null,"SJAG_04038":null,"YER164W":null},"has_protein_features":false,"name":"CHD1","ortholog_annotations":[{"gene_uniquename":"YER164W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01653","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER164W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04038","reference_uniquename":"PMID:29761456"}],"product":"Chromatin remodeler that regulates various aspects of transcription; acts in conjunction with Isw1b to regulate chromatin structure, maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains chromo domain, helicase domain and DNA-binding domain; component of both SAGA and SLIK complexes; in human, deletion of CHD1 is a frequent event in prostate cancer","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000966","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER164W"}


id: YER165C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene DNF1/YER166W","secondary_identifier":"SGD:S000028762","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER165C-A"}


id: YER165W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04427":null,"YER165W":null},"has_protein_features":false,"name":"PAB1","ortholog_annotations":[{"gene_uniquename":"YER165W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04427","reference_uniquename":"PMID:29761456"}],"product":"Poly(A) binding protein; interacts with the cleavage factor complex CF I, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; stimulates, but is not required for the deadenylation activity of the Pan2p-Pan3p poly(A)-ribonuclease complex; role in preventing L-A mycovirus pathogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000967","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER165W"}


id: YER166W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01731":null,"SJAG_02897":null,"YER166W":null},"has_protein_features":false,"name":"DNF1","ortholog_annotations":[{"gene_uniquename":"YER166W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01731","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER166W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02897","reference_uniquename":"PMID:29761456"}],"product":"Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF1 has a paralog, DNF2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000968","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER166W"}


id: YER167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BCK2","product":"Serine/threonine-rich protein involved in PKC1 signaling pathway; protein kinase C (PKC1) signaling pathway controls cell integrity; overproduction suppresses pkc1 mutations","secondary_identifier":"SGD:S000000969","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER167W"}


id: YER168C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01704":null,"SJAG_02288":null,"YER168C":null},"has_protein_features":false,"name":"CCA1","ortholog_annotations":[{"gene_uniquename":"YER168C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01704","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER168C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02288","reference_uniquename":"PMID:29761456"}],"product":"ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites; human homolog TRNT1 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000970","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER168C"}


id: YER169W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03041":null,"YER169W":null},"has_protein_features":false,"name":"RPH1","ortholog_annotations":[{"gene_uniquename":"YER169W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03041","reference_uniquename":"PMID:29761456"}],"product":"JmjC domain-containing histone demethylase; targets tri- and dimethylated H3K36; associates with actively transcribed regions and promotes elongation; repressor of autophagy-related genes in nutrient-replete conditions; damage-responsive repressor of PHR1; phosphorylated by the Rad53p-dependent DNA damage checkpoint pathway and by a Rim1p-mediated event during starvation; target of stress-induced hormesis; RPH1 has a paralog, GIS1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000971","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER169W"}


id: YER170W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02038":null,"YER170W":null},"has_protein_features":false,"name":"ADK2","ortholog_annotations":[{"gene_uniquename":"YER170W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02038","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000972","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER170W"}


id: YER171W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00995":null,"YER171W":null},"has_protein_features":false,"name":"RAD3","ortholog_annotations":[{"gene_uniquename":"YER171W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00995","reference_uniquename":"PMID:29761456"}],"product":"5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000973","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER171W"}


id: YER172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02295":null,"YER172C":null},"has_protein_features":false,"name":"BRR2","ortholog_annotations":[{"gene_uniquename":"YER172C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02295","reference_uniquename":"PMID:29761456"}],"product":"RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000974","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER172C"}


id: YER172C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF RAD24/YER173W","secondary_identifier":"SGD:S000028763","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER172C-A"}


id: YER173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02563":null,"YER173W":null},"has_protein_features":false,"name":"RAD24","ortholog_annotations":[{"gene_uniquename":"YER173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02563","reference_uniquename":"PMID:29761456"}],"product":"Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000975","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER173W"}


id: YER174C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00822":null,"YER174C":null},"has_protein_features":false,"name":"GRX4","ortholog_annotations":[{"gene_uniquename":"YER174C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00822","reference_uniquename":"PMID:29761456"}],"product":"Glutathione-dependent oxidoreductase and glutathione S-transferase; hydroperoxide/superoxide-radical responsive monothiol glutaredoxin subfamily member with Grx3p and Grx5p; protects cells from oxidative damage with GRX3 and GRX5; with Grx3p, promotes dissociation of Aft1p from iron regulon gene promoters and subsequent nuclear export in iron-replete conditions, regulating iron homeostasis; involved with Grx3p in Sir2p deglutathionylation, restoring deacetylase activity after disulfide stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000976","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER174C"}


id: YER175C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02973":null,"YER175C":null},"has_protein_features":false,"name":"TMT1","ortholog_annotations":[{"gene_uniquename":"YER175C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02973","reference_uniquename":"PMID:29761456"}],"product":"Trans-aconitate methyltransferase; cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000977","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER175C"}


id: YER175W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028625","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER175W-A"}


id: YER176W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM32","product":"DNA dependent ATPase/DNA helicase; helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes","secondary_identifier":"SGD:S000000978","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER176W"}


id: YER177W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02266":null,"SJAG_02576":null,"YER177W":null},"has_protein_features":false,"name":"BMH1","ortholog_annotations":[{"gene_uniquename":"YER177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02266","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02576","reference_uniquename":"PMID:29761456"}],"product":"14-3-3 protein, major isoform; involved in post-transcriptional control of the proteome; binds to both proteins and to DNA, including replication origins; regulates exocytosis, vesicle transport, Ras/MAPK and rapamycin-sensitive signaling, aggresome formation, the spindle position checkpoint and meiotic commitment; protein abundance and relative distribution to the nucleus increase upon DNA replication stress; antiapoptotic gene; similar to several human 14-3-3 proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000979","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER177W"}


id: YER178W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02006":null,"YER178W":null},"has_protein_features":false,"name":"PDA1","ortholog_annotations":[{"gene_uniquename":"YER178W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02006","reference_uniquename":"PMID:29761456"}],"product":"E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex; catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose; PDH complex is concentrated in spots within the mitochondrial matrix, often near the ERMES complex and near peroxisomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000980","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER178W"}


id: YER179W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02267":null,"YER179W":null},"has_protein_features":false,"name":"DMC1","ortholog_annotations":[{"gene_uniquename":"YER179W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02267","reference_uniquename":"PMID:29761456"}],"product":"Meiosis-specific recombinase required for double-strand break repair; also required for pairing between homologous chromosomes and for the normal morphogenesis of synaptonemal complex; binds ssDNA and dsDNA, forms helical filaments; potent inhibitor of the ATPase activity of  Srs2p helicase, blocking its ssDNA translocating motor activity and inhibiting its antirecombinase activity; stimulated by Rdh54p; homolog of Rad51p and the bacterial RecA protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000981","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER179W"}


id: YER180C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ISC10","product":"Meiosis-specific MAPK inhibitor; binds Smk1p during meiosis I; links APC/C-Ama1 to Smk1p activation; required for sporulation; transcript is induced 7.5 hr after induction of meiosis; Isc10p is ubiquitylated and degraded in an Ama1p-dependent manner upon completion of meiosis II","secondary_identifier":"SGD:S000000982","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER180C"}


id: YER180C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03365":null,"YER180C-A":null},"has_protein_features":false,"name":"SLO1","ortholog_annotations":[{"gene_uniquename":"YER180C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03365","reference_uniquename":"PMID:29761456"}],"product":"Protein interacting with Arl3p; Arl3p is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028437","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER180C-A"}


id: YER181C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Mitochondrial protein of unknown function; conserved among S. cerevisiae strains; extensively overlaps a Ty1 LTR; YER181C is not an essential gene","secondary_identifier":"SGD:S000000983","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER181C"}


id: YER182W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04007":null,"SJAG_04895":null,"YER182W":null},"has_protein_features":false,"name":"FMP10","ortholog_annotations":[{"gene_uniquename":"YER182W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04007","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YER182W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04895","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000000984","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER182W"}


id: YER183C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01616":null,"YER183C":null},"has_protein_features":false,"name":"FAU1","ortholog_annotations":[{"gene_uniquename":"YER183C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01616","reference_uniquename":"PMID:29761456"}],"product":"5,10-methenyltetrahydrofolate synthetase; involved in folic acid biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000985","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER183C"}


id: YER184C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TOG1","product":"Transcriptional activator of oleate genes; regulates genes involved in fatty acid utilization; zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source","secondary_identifier":"SGD:S000000986","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER184C"}


id: YER185W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00018":null,"SJAG_00587":null,"SJAG_00589":null,"SJAG_01095":null,"SJAG_02114":null,"SJAG_02132":null,"SJAG_02581":null,"SJAG_02943":null,"SJAG_02957":null,"YER185W":null},"has_protein_features":false,"name":"PUG1","ortholog_annotations":[{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00018","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00587","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00589","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01095","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02114","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02132","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02581","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02943","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YER185W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02957","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane protein involved in protoprophyrin and heme transport; roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000000987","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER185W"}


id: YER186C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000000988","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER186C"}


id: YER186W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a protein; the YER186W-A was removed because it does not begin with a start codon or end with a stop codon, and has an in-frame internal stop codon (see the Locus History for more details)","secondary_identifier":"SGD:S000007427","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER186W-A"}


id: YER187W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; induced in respiratory-deficient cells","secondary_identifier":"SGD:S000000989","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER187W"}


id: YER188C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028764","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER188C-A"}


id: YER188W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p","secondary_identifier":"SGD:S000000990","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER188W"}


id: YER189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000000991","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER189W"}


id: YER190C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YRF1-2/YER190W; identified by gene-trapping, expression analysis, and homology","secondary_identifier":"SGD:S000028626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER190C-A"}


id: YER190C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER190C-B"}


id: YER190W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YRF1-2","product":"Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation","secondary_identifier":"SGD:S000000992","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YER190W"}


id: YFL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02978":null,"YFL001W":null},"has_protein_features":false,"name":"DEG1","ortholog_annotations":[{"gene_uniquename":"YFL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02978","reference_uniquename":"PMID:29761456"}],"product":"tRNA:pseudouridine synthase; introduces pseudouridines at position 38 or 39 in tRNA; also responsible for pseudouracil modification of some mRNAs; important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001895","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL001W"}


id: YFL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00616":null,"YFL002C":null},"has_protein_features":false,"name":"SPB4","ortholog_annotations":[{"gene_uniquename":"YFL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00616","reference_uniquename":"PMID:29761456"}],"product":"Putative ATP-dependent RNA helicase; nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001894","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL002C"}


id: YFL003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MSH4","product":"Protein involved in meiotic recombination; required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein","secondary_identifier":"SGD:S000001891","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL003C"}


id: YFL004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03442":null,"YFL004W":null},"has_protein_features":false,"name":"VTC2","ortholog_annotations":[{"gene_uniquename":"YFL004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03442","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; important regulator of substrate invagination from the vacuolar membrane; targeted to vacuole via AP-3 pathway; VTC2 has a paralog, VTC3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001890","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL004W"}


id: YFL005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00430":null,"SJAG_02640":null,"YFL005W":null},"has_protein_features":false,"name":"SEC4","ortholog_annotations":[{"gene_uniquename":"YFL005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00430","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02640","reference_uniquename":"PMID:26896847"}],"product":"Rab family GTPase; essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane; exocyst association is negatively regulated via phosphorylation by Cdc5p during cytokinesis","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001889","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL005W"}


id: YFL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YFL006W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YFL007W","secondary_identifier":"SGD:S000001888","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL006W"}


id: YFL007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00591":null,"SJAG_00837":null,"SJAG_02625":null,"SJAG_05252":null,"YFL007W":null},"has_protein_features":false,"name":"BLM10","ortholog_annotations":[{"gene_uniquename":"YFL007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00591","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00837","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02625","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05252","reference_uniquename":"PMID:26896847"}],"product":"Proteasome activator; binds the core proteasome (CP) and stimulates proteasome-mediated protein degradation by inducing gate opening; required for sequestering CP into proteasome storage granule (PSG) during quiescent phase and for nuclear import of CP in proliferating cells; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001887","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL007W"}


id: YFL008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01831":null,"YFL008W":null},"has_protein_features":false,"name":"SMC1","ortholog_annotations":[{"gene_uniquename":"YFL008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01831","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the multiprotein cohesin complex; essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001886","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL008W"}


id: YFL009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02162":null,"SJAG_02651":null,"YFL009W":null},"has_protein_features":false,"name":"CDC4","ortholog_annotations":[{"gene_uniquename":"YFL009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02162","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02651","reference_uniquename":"PMID:29761456"}],"product":"F-box protein required for both the G1/S and G2/M phase transitions; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCFCdc4 complex; SCFCdc4 acts as a ubiquitin-protein ligase directing ubiquitination of cyclin-dependent kinase (CDK) phosphorylated substrates, such as: Sic1p, Far1p, Cdc6p, Clb6p, and Cln3p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001885","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL009W"}


id: YFL010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03049":null,"YFL010C":null},"has_protein_features":false,"name":"WWM1","ortholog_annotations":[{"gene_uniquename":"YFL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03049","reference_uniquename":"PMID:29761456"}],"product":"WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001884","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL010C"}


id: YFL010W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AUA1","product":"Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease","secondary_identifier":"SGD:S000001955","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL010W-A"}


id: YFL011W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YFL011W":null},"has_protein_features":false,"name":"HXT10","ortholog_annotations":[{"gene_uniquename":"YFL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YFL011W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:26896847"}],"product":"Hexose transporter; expressed at low levels and expression is repressed by glucose","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000001883","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL011W"}


id: YFL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin","secondary_identifier":"SGD:S000001882","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL012W"}


id: YFL012W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene IES1/YFL013C","secondary_identifier":"SGD:S000002964","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL012W-A"}


id: YFL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IES1","product":"Subunit of the INO80 chromatin remodeling complex; relocalizes to the cytosol in response to hypoxia","secondary_identifier":"SGD:S000001881","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL013C"}


id: YFL013W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL013W-A"}


id: YFL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00223":null,"YFL014W":null},"has_protein_features":false,"name":"HSP12","ortholog_annotations":[{"gene_uniquename":"YFL014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00223","reference_uniquename":"PMID:29761456"}],"product":"Plasma membrane protein involved in maintaining membrane organization; involved in maintaining organization during stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001880","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL014W"}


id: YFL015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene","secondary_identifier":"SGD:S000001879","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL015C"}


id: YFL015W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF YFL015C","secondary_identifier":"SGD:S000028765","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL015W-A"}


id: YFL016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01052":null,"YFL016C":null},"has_protein_features":false,"name":"MDJ1","ortholog_annotations":[{"gene_uniquename":"YFL016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01052","reference_uniquename":"PMID:29761456"}],"product":"Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001878","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL016C"}


id: YFL017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GNA1","product":"Glucosamine-6-phosphate acetyltransferase; evolutionarily conserved; required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA","secondary_identifier":"SGD:S000001877","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL017C"}


id: YFL017W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01870":null,"YFL017W-A":null},"has_protein_features":false,"name":"SMX2","ortholog_annotations":[{"gene_uniquename":"YFL017W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01870","reference_uniquename":"PMID:29761456"}],"product":"Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002965","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL017W-A"}


id: YFL018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03290":null,"YFL018C":null},"has_protein_features":false,"name":"LPD1","ortholog_annotations":[{"gene_uniquename":"YFL018C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03290","reference_uniquename":"PMID:29761456"}],"product":"Dihydrolipoamide dehydrogenase; the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes; PDH complex is concentrated in spots within the mitochondrial matrix, often near the ERMES complex and near peroxisomes; LPD1 has a paralog, IRC15, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001876","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL018C"}


id: YFL019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved across S. cerevisiae strains; YFL019C is not an essential gene","secondary_identifier":"SGD:S000001875","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL019C"}


id: YFL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU5","product":"Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme","secondary_identifier":"SGD:S000001874","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL020C"}


id: YFL021C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF GAT1/YFL021W","secondary_identifier":"SGD:S000028766","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL021C-A"}


id: YFL021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02730":null,"YFL021W":null},"has_protein_features":false,"name":"GAT1","ortholog_annotations":[{"gene_uniquename":"YFL021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02730","reference_uniquename":"PMID:29761456"}],"product":"Transcriptional activator of nitrogen catabolite repression genes; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p; different translational starts produce two major and two minor isoforms that are differentially regulated and localized","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001873","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL021W"}


id: YFL022C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03626":null,"YFL022C":null},"has_protein_features":false,"name":"FRS2","ortholog_annotations":[{"gene_uniquename":"YFL022C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03626","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001872","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL022C"}


id: YFL023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04093":null,"YFL023W":null},"has_protein_features":false,"name":"BUD27","ortholog_annotations":[{"gene_uniquename":"YFL023W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04093","reference_uniquename":"PMID:29761456"}],"product":"Unconventional prefoldin protein involved in translation initiation; required for correct assembly of RNAP I, II, and III in an Rpb5p-dependent manner; shuttles between nucleus and cytoplasm; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; mutations affect TOR signaling; ortholog of human URI/RMP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001871","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL023W"}


id: YFL024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03792":null,"YFL024C":null},"has_protein_features":false,"name":"EPL1","ortholog_annotations":[{"gene_uniquename":"YFL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03792","reference_uniquename":"PMID:29761456"}],"product":"Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb; coding sequence contains length polymorphisms in different strains","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001870","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL024C"}


id: YFL025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01570":null,"YFL025C":null},"has_protein_features":false,"name":"BST1","ortholog_annotations":[{"gene_uniquename":"YFL025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01570","reference_uniquename":"PMID:29761456"}],"product":"GPI inositol deacylase of the endoplasmic reticulum (ER); negatively regulates COPII vesicle formation; prevents production of vesicles with defective subunits; required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; functional ortholog of human PGAP1, mutation of which is associated with intellectual disability and encephalopathy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001869","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL025C"}


id: YFL026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01978":null,"YFL026W":null},"has_protein_features":false,"name":"STE2","ortholog_annotations":[{"gene_uniquename":"YFL026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01978","reference_uniquename":"PMID:29761456"}],"product":"Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001868","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL026W"}


id: YFL027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04938":null,"YFL027C":null},"has_protein_features":false,"name":"GYP8","ortholog_annotations":[{"gene_uniquename":"YFL027C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04938","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport; localizes to the ER and peroxisomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001867","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL027C"}


id: YFL028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01944":null,"YFL028C":null},"has_protein_features":false,"name":"CAF16","ortholog_annotations":[{"gene_uniquename":"YFL028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01944","reference_uniquename":"PMID:29761456"}],"product":"Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001866","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL028C"}


id: YFL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01000":null,"YFL029C":null},"has_protein_features":false,"name":"CAK1","ortholog_annotations":[{"gene_uniquename":"YFL029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01000","reference_uniquename":"PMID:29761456"}],"product":"Cyclin-dependent kinase-activating kinase; required for passage through the cell cycle; phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases; required for premeiotic DNA synthesis, expression of early and middle sporulation specific genes and direct phosphorylation of the Smk1p MAPK to regulate spore morphogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001865","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL029C"}


id: YFL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AGX1","product":"Alanine:glyoxylate aminotransferase (AGT); catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; similar to mammalian and plant alanine:glyoxylate aminotransferases; human homolog AGXT complements yeast null mutant","secondary_identifier":"SGD:S000001864","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL030W"}


id: YFL031C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps HAC1/YFL031W; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL031C-A"}


id: YFL031W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HAC1","product":"Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates unfolded protein response via UPRE binding and membrane biogenesis; translation initiation repressed under non-stress conditions by un-spliced intron that interacts with 5'-UTR; under ER stress Ire1p nuclease cleaves out inhibitory intron and triggers efficient Hac1p translation; two functional forms of Hac1p are produced; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000001863","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL031W"}


id: YFL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene","secondary_identifier":"SGD:S000001862","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL032W"}


id: YFL033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00256":null,"SJAG_00704":null,"SJAG_02498":null,"YFL033C":null},"has_protein_features":false,"name":"RIM15","ortholog_annotations":[{"gene_uniquename":"YFL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00256","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00704","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02498","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase involved in cell proliferation in response to nutrients; glucose-repressible; involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; phosphorylates Igo1p and Igo2p; substrate of Pho80p-Pho85p kinase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001861","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL033C"}


id: YFL034C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00220":null,"YFL034C-A":null},"has_protein_features":false,"name":"RPL22B","ortholog_annotations":[{"gene_uniquename":"YFL034C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00220","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L22A; required for translation of long 5' UTR of IME1 mRNA and meiotic entry; autoregulates splicing of its pre-m-RNA; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006436","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL034C-A"}


id: YFL034C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00236":null,"YFL034C-B":null},"has_protein_features":false,"name":"MOB2","ortholog_annotations":[{"gene_uniquename":"YFL034C-B","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00236","reference_uniquename":"PMID:29761456"}],"product":"Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001859","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL034C-B"}


id: YFL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01381":null,"SJAG_02715":null,"YFL034W":null},"has_protein_features":false,"name":"MIL1","ortholog_annotations":[{"gene_uniquename":"YFL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01381","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02715","reference_uniquename":"PMID:29761456"}],"product":"Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001860","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL034W"}


id: YFL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03014":null,"YFL036W":null},"has_protein_features":false,"name":"RPO41","ortholog_annotations":[{"gene_uniquename":"YFL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03014","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation; Rpo41p also synthesizes RNA primers for mitochondrial DNA replication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001858","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL036W"}


id: YFL037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04003":null,"YFL037W":null},"has_protein_features":false,"name":"TUB2","ortholog_annotations":[{"gene_uniquename":"YFL037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04003","reference_uniquename":"PMID:29761456"}],"product":"Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001857","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL037W"}


id: YFL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02640":null,"YFL038C":null},"has_protein_features":false,"name":"YPT1","ortholog_annotations":[{"gene_uniquename":"YFL038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02640","reference_uniquename":"PMID:29761456"}],"product":"Rab family GTPase; involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by type II protein geranylgeranyltransferase (Bet2p-Bet4p); binds to unspliced HAC1 mRNA; regulates the unfolded protein response (UPR) by promoting the decay of HAC1 RNA; localizes to the early Golgi, the transitional Golgi and ER membranes, pre-autophagosomal structures, and cytoplasmic vesicles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001856","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL038C"}


id: YFL039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03145":null,"YFL039C":null},"has_protein_features":false,"name":"ACT1","ortholog_annotations":[{"gene_uniquename":"YFL039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03145","reference_uniquename":"PMID:29761456"}],"product":"Actin, structural protein in cytoskeleton; involved in cell polarization, endocytosis, and other cytoskeletal functions; monomeric actin in the nucleus plays a role in INO80 chromatin remodeling","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001855","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL039C"}


id: YFL040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport","secondary_identifier":"SGD:S000001854","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL040W"}


id: YFL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04677":null,"YFL041W":null},"has_protein_features":false,"name":"FET5","ortholog_annotations":[{"gene_uniquename":"YFL041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04677","reference_uniquename":"PMID:29761456"}],"product":"Multicopper oxidase; integral membrane protein with similarity to Fet3p; targeted to vacuole via AP-3 pathway; may have role in iron transport","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001853","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL041W"}


id: YFL041W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028547","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL041W-A"}


id: YFL042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01329":null,"YFL042C":null},"has_protein_features":false,"name":"LAM5","ortholog_annotations":[{"gene_uniquename":"YFL042C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01329","reference_uniquename":"PMID:29761456"}],"product":"Putative sterol transfer protein; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; has both GRAM and StART-like (VASt) domains; localizes to membrane contact sites throughout the cell, including nucleus-vacuole junctions and ER-mitochondrial contact sites","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001852","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL042C"}


id: YFL043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YFL043C was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YFL042C","secondary_identifier":"SGD:S000001851","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL043C"}


id: YFL044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01768":null,"YFL044C":null},"has_protein_features":false,"name":"OTU1","ortholog_annotations":[{"gene_uniquename":"YFL044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01768","reference_uniquename":"PMID:29761456"}],"product":"Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001850","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL044C"}


id: YFL045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02783":null,"YFL045C":null},"has_protein_features":false,"name":"SEC53","ortholog_annotations":[{"gene_uniquename":"YFL045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02783","reference_uniquename":"PMID:29761456"}],"product":"Phosphomannomutase; involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen; human homolog PMM2 complements yeast mutants","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001849","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL045C"}


id: YFL046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03399":null,"SJAG_03873":null,"YFL046W":null},"has_protein_features":false,"name":"FMP32","ortholog_annotations":[{"gene_uniquename":"YFL046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03399","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFL046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03873","reference_uniquename":"PMID:29761456"}],"product":"Regulator of mitochondrial proline metabolism; tethered with Put7p to inner mitochondrial membrane in large hetero-oligomeric complex, abundance of which is regulated by proline; involved in mitochondrial proline homeostasis and cellular redox balance; null exhibits pronounced defect in proline utilization, and can be functionally complemented by expression of human homolog MCUR1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001848","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL046W"}


id: YFL047W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03748":null,"YFL047W":null},"has_protein_features":false,"name":"RGD2","ortholog_annotations":[{"gene_uniquename":"YFL047W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03748","reference_uniquename":"PMID:29761456"}],"product":"GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001847","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL047W"}


id: YFL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02839":null,"YFL048C":null},"has_protein_features":false,"name":"EMP47","ortholog_annotations":[{"gene_uniquename":"YFL048C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02839","reference_uniquename":"PMID:29761456"}],"product":"Integral membrane component of ER-derived COPII-coated vesicles; functions in ER to Golgi transport; forms a complex with Ssp120p that may function in trafficking plasma membrane glycoproteins through early secretory pathway; EMP47 has a paralog, EMP46, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001846","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL048C"}


id: YFL049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04005":null,"YFL049W":null},"has_protein_features":false,"name":"SWP82","ortholog_annotations":[{"gene_uniquename":"YFL049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04005","reference_uniquename":"PMID:29761456"}],"product":"Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001845","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL049W"}


id: YFL050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03516":null,"YFL050C":null},"has_protein_features":false,"name":"ALR2","ortholog_annotations":[{"gene_uniquename":"YFL050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03516","reference_uniquename":"PMID:29761456"}],"product":"Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001844","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL050C"}


id: YFL051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP fusion protein localizes to the cell periphery while mCherry fusion protein localizes to both the cell periphery and vacuole; YFL051C is not an essential gene","secondary_identifier":"SGD:S000001843","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL051C"}


id: YFL052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ZNF1","product":"Zinc cluster transcription factor that regulates respiratory growth; binds to promoters of genes involved in respiration, gluconeogenesis, and the glyoxylate shunt; required for normal carbon source utilization and adaptation to pH, osmotic and ethanol stress especially during non-fermentative metabolism","secondary_identifier":"SGD:S000001842","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL052W"}


id: YFL053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04320":null,"YFL053W":null},"has_protein_features":false,"name":"DAK2","ortholog_annotations":[{"gene_uniquename":"YFL053W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04320","reference_uniquename":"PMID:29761456"}],"product":"Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001841","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL053W"}


id: YFL054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AQY3","product":"Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol","secondary_identifier":"SGD:S000001840","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL054C"}


id: YFL055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AGP3","product":"Low-affinity amino acid permease; may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition","secondary_identifier":"SGD:S000001839","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL055W"}


id: YFL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AAD16","product":"Putative aryl alcohol dehydrogenase; similar to Phanerochaete chrysosporium aryl alcohol dehydrogenase; ORFs AAD6/YFL056C and AAD16/YFL057C are displaced from one another by -1 frameshift; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family","secondary_identifier":"SGD:S000001837","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL057C"}


id: YFL058W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04866":null,"YFL058W":null},"has_protein_features":false,"name":"THI5","ortholog_annotations":[{"gene_uniquename":"YFL058W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04866","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001836","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL058W"}


id: YFL059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00283":null,"YFL059W":null},"has_protein_features":false,"name":"SNZ3","ortholog_annotations":[{"gene_uniquename":"YFL059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00283","reference_uniquename":"PMID:29761456"}],"product":"Pyridoxal-5'-phosphate synthase; involved in thiamine and pyridoxine biosynthesis; member of a stationary phase-induced gene family where transcriptional induction precedes the diauxic shift; induced in the absence of thiamine in a Thi2/3p-dependent manner and repressed in its presence; forms a co-regulated gene pair with SNO3; paralog of SNZ1 and SNZ2","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001835","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL059W"}


id: YFL060C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00691":null,"YFL060C":null},"has_protein_features":false,"name":"SNO3","ortholog_annotations":[{"gene_uniquename":"YFL060C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00691","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001834","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL060C"}


id: YFL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DDI3","product":"Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI2 and Ddi2p","secondary_identifier":"SGD:S000001833","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL061W"}


id: YFL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COS4","product":"Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins","secondary_identifier":"SGD:S000001832","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL062W"}


id: YFL063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001831","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL063W"}


id: YFL064C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001830","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL064C"}


id: YFL065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation","secondary_identifier":"SGD:S000001829","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL065C"}


id: YFL066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Helicase-like protein encoded within the telomeric Y' element; induced by treatment with 8-methoxypsoralen and UVA irradiation; SWAT-GFP and mCherry fusion proteins localize to the nucleus","secondary_identifier":"SGD:S000001828","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL066C"}


id: YFL067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; down-regulated at low calcium levels; mCherry fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000001827","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL067W"}


id: YFL068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cytosol","secondary_identifier":"SGD:S000001826","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFL068W"}


id: YFR001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04919":null,"YFR001W":null},"has_protein_features":false,"name":"LOC1","ortholog_annotations":[{"gene_uniquename":"YFR001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04919","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein involved in the asymmetric localization of ASH1 mRNA; binds cooperatively with She2p to the E3 zip-code element in the 3'-UTR of the mRNA; constituent of 66S pre-ribosomal particles involved in pre-rRNA processing and nuclear export of the 60S subunit; may facilitate Rpl43p loading; required post-transcriptionally for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; relocalizes from nucleus to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001897","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR001W"}


id: YFR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00093":null,"SJAG_01185":null,"YFR002W":null},"has_protein_features":false,"name":"NIC96","ortholog_annotations":[{"gene_uniquename":"YFR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00093","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01185","reference_uniquename":"PMID:29761456"}],"product":"Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001898","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR002W"}


id: YFR003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04999":null,"YFR003C":null},"has_protein_features":false,"name":"YPI1","ortholog_annotations":[{"gene_uniquename":"YFR003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04999","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001899","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR003C"}


id: YFR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02900":null,"YFR004W":null},"has_protein_features":false,"name":"RPN11","ortholog_annotations":[{"gene_uniquename":"YFR004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02900","reference_uniquename":"PMID:29761456"}],"product":"Metalloprotease subunit of 19S regulatory particle; part of 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001900","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR004W"}


id: YFR005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04538":null,"YFR005C":null},"has_protein_features":false,"name":"SAD1","ortholog_annotations":[{"gene_uniquename":"YFR005C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04538","reference_uniquename":"PMID:29761456"}],"product":"Conserved zinc-finger domain protein involved in pre-mRNA splicing; critical for splicing of nearly all intron-containing genes; required for assembly of U4 snRNA into the U4/U6 particle","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001901","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR005C"}


id: YFR006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene","secondary_identifier":"SGD:S000001902","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR006W"}


id: YFR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00533":null,"YFR007W":null},"has_protein_features":false,"name":"YFH7","ortholog_annotations":[{"gene_uniquename":"YFR007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00533","reference_uniquename":"PMID:29761456"}],"product":"Putative kinase with similarity to the PRK/URK/PANK kinase subfamily; the PRK/URK/PANK subfamily of P-loop kinases is also known as phosphoribulokinase/uridine kinase/bacterial pantothenate kinase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001903","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR007W"}


id: YFR008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FAR7","product":"Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000001904","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR008W"}


id: YFR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00541":null,"YFR009W":null},"has_protein_features":false,"name":"GCN20","ortholog_annotations":[{"gene_uniquename":"YFR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00541","reference_uniquename":"PMID:29761456"}],"product":"Positive regulator of the Gcn2p kinase activity; important for disaggregation of ordered and disordered protein aggregates; forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA; suppresses frameshifting at stalled ribosomes","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001905","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR009W"}


id: YFR009W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YFR009W; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028823","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR009W-A"}


id: YFR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02244":null,"YFR010W":null},"has_protein_features":false,"name":"UBP6","ortholog_annotations":[{"gene_uniquename":"YFR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02244","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-specific protease; situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains en bloc, rather than from the distal tip of the chain; negatively regulates degradation of ubiquitinated proteins by the proteasome; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance; human homolog UBP14 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001906","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR010W"}


id: YFR010W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YFR011C; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028824","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR010W-A"}


id: YFR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05241":null,"YFR011C":null},"has_protein_features":false,"name":"MIC19","ortholog_annotations":[{"gene_uniquename":"YFR011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05241","reference_uniquename":"PMID:29761456"}],"product":"Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic19p is peripheral to the inner membrane and may connect Mic60p with the Mic10p-Mic12p-Mic27p subcomplex; both yeast and human Mic19p become oxidized, and oxidation may regulate MICOS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001907","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR011C"}


id: YFR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01189":null,"SJAG_04058":null,"YFR012W":null},"has_protein_features":false,"name":"DCV1","ortholog_annotations":[{"gene_uniquename":"YFR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01189","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04058","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001908","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR012W"}


id: YFR012W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by homology","secondary_identifier":"SGD:S000007606","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR012W-A"}


id: YFR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IOC3","product":"Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; promotes nucleosome shifts in the 5 prime direction; IOC3 has a paralog, ESC8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001909","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR013W"}


id: YFR014C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02858":null,"YFR014C":null},"has_protein_features":false,"name":"CMK1","ortholog_annotations":[{"gene_uniquename":"YFR014C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02858","reference_uniquename":"PMID:29761456"}],"product":"Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001910","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR014C"}


id: YFR015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GSY1","product":"Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress","secondary_identifier":"SGD:S000001911","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR015C"}


id: YFR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIP5","product":"Protein that positively regulates actin assembly; forms a homodimer and interacts with G-actin; localization to the bud neck and bud tip requires Spa2p; YFR016C is not an essential gene","secondary_identifier":"SGD:S000001912","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR016C"}


id: YFR017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IGD1","product":"Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001913","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR017C"}


id: YFR018C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; SWAT-GFP and seamless GFP fusion proteins localize to the endoplasmic reticulum and mCherry fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000001914","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR018C"}


id: YFR019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00638":null,"YFR019W":null},"has_protein_features":false,"name":"FAB1","ortholog_annotations":[{"gene_uniquename":"YFR019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00638","reference_uniquename":"PMID:29761456"}],"product":"1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001915","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR019W"}


id: YFR020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSS2","product":"Protein of unknown function, secreted when constitutively expressed; SWAT-GFP fusion protein localizes to the endoplasmic reticulum (ER) and extracellular region, while mCherry fusion protein localizes to the ER and vacuole; mRNA identified as translated by ribosome profiling data; CSS2 is a non-essential gene","secondary_identifier":"SGD:S000001916","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR020W"}


id: YFR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01783":null,"SJAG_04963":null,"YFR021W":null},"has_protein_features":false,"name":"ATG18","ortholog_annotations":[{"gene_uniquename":"YFR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01783","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR021W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04963","reference_uniquename":"PMID:29761456"}],"product":"Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (CVT) pathway; binds PtdIns(3,5)P2, PI3P and PI4P; WD-40 repeat-containing protein and PROPPIN family member; relocalizes from the vacuole to cytoplasm upon replication stress; forms higher order helical assemblies; mammalian homologs include: WIPI1, WIPI2, WIPI3 and WDR45; human WDR45 mutations cause static encephalopathy of childhood with neurodegeneration in adulthood (SENDA)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001917","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR021W"}


id: YFR022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00803":null,"SJAG_01686":null,"YFR022W":null},"has_protein_features":false,"name":"ROG3","ortholog_annotations":[{"gene_uniquename":"YFR022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00803","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01686","reference_uniquename":"PMID:29761456"}],"product":"Alpha-arrestin involved in ubiquitin-dependent endocytosis; contributes to desensitization of agonist-occupied alpha-factor receptor Ste2p by Rsp5p-independent internalization; PPXY motif-mediated binding of the ubiquitin ligase Rsp5p is not required for adaptation; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; SWAT-GFP and mCherry fusion proteins localize to the cytosol; ROG3 has a paralog, ROD1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001918","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR022W"}


id: YFR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PES4","product":"Putative RNA binding protein; partially redundant function with paralog MIP6 in the steady-state expression, translational timing and localization of a subset of Ndt80-dependent mRNAs that are protected until translated near the end of meiosis II; regulator of meiotic commitment; redundant function with MIP6 in sporulation; localizes to puncta near the openings of the prospore membrane; suppressor of a DNA polymerase epsilon mutation; induced by NDT80","secondary_identifier":"SGD:S000001919","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR023W"}


id: YFR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Deleted ORF; does not encode a discrete protein; YFR024C was originally annotated as a separate ORF, but was later removed because it was demonstrated to be theC-terminus of LSB3/YFR024C-A","secondary_identifier":"SGD:S000001920","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR024C"}


id: YFR024C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00970":null,"YFR024C-A":null},"has_protein_features":false,"name":"LSB3","ortholog_annotations":[{"gene_uniquename":"YFR024C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00970","reference_uniquename":"PMID:29761456"}],"product":"Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002968","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR024C-A"}


id: YFR025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00248":null,"YFR025C":null},"has_protein_features":false,"name":"HIS2","ortholog_annotations":[{"gene_uniquename":"YFR025C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00248","reference_uniquename":"PMID:29761456"}],"product":"Histidinolphosphatase; catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001921","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR025C"}


id: YFR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ULI1","product":"Protein of unknown function; involved in and induced by the endoplasmic reticulum unfolded protein response (UPR); SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum","secondary_identifier":"SGD:S000001922","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR026C"}


id: YFR027W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04791":null,"YFR027W":null},"has_protein_features":false,"name":"ECO1","ortholog_annotations":[{"gene_uniquename":"YFR027W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04791","reference_uniquename":"PMID:29761456"}],"product":"Acetyltransferase required for sister chromatid cohesion; elicits cohesin dimerization during S phase; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by Cdc28p, Cdc7p, Mck1p to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; relative distribution to nucleus increases upon DNA replication stress; mutations in human homolog ESCO2 cause Roberts syndrome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001923","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR027W"}


id: YFR028C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00082":null,"YFR028C":null},"has_protein_features":false,"name":"CDC14","ortholog_annotations":[{"gene_uniquename":"YFR028C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00082","reference_uniquename":"PMID:29761456"}],"product":"Protein phosphatase required for mitotic exit; required for rDNA segregation, cytokinesis, meiosis I spindle disassembly, environmental stress response, autophagy during meiosis; downregulates microautophagy induction after TORC1 inactivation; held in nucleolus by Cdc55p in early meiosis, liberated by FEAR and Mitotic Exit Network in anaphase; sequestered in metaphase II, released upon entry into anaphase II; human homolog CDC14A can complement thermosensitivity of cdc14-1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001924","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR028C"}


id: YFR029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PTR3","product":"Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p","secondary_identifier":"SGD:S000001925","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR029W"}


id: YFR030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01693":null,"YFR030W":null},"has_protein_features":false,"name":"MET10","ortholog_annotations":[{"gene_uniquename":"YFR030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01693","reference_uniquename":"PMID:29761456"}],"product":"Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001926","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR030W"}


id: YFR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03832":null,"YFR031C":null},"has_protein_features":false,"name":"SMC2","ortholog_annotations":[{"gene_uniquename":"YFR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03832","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; essential SMC chromosomal ATPase family member that forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for clustering of tRNA genes at the nucleolus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001927","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR031C"}


id: YFR031C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00034":null,"SJAG_02312":null,"YFR031C-A":null},"has_protein_features":false,"name":"RPL2A","ortholog_annotations":[{"gene_uniquename":"YFR031C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR031C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02312","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002104","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR031C-A"}


id: YFR032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRT5","product":"Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation","secondary_identifier":"SGD:S000001928","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR032C"}


id: YFR032C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03127":null,"YFR032C-A":null},"has_protein_features":false,"name":"RPL29","ortholog_annotations":[{"gene_uniquename":"YFR032C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03127","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000006437","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR032C-A"}


id: YFR032C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MIN10","product":"Mitochondrial protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR032C-B"}


id: YFR033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01490":null,"YFR033C":null},"has_protein_features":false,"name":"QCR6","ortholog_annotations":[{"gene_uniquename":"YFR033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01490","reference_uniquename":"PMID:29761456"}],"product":"Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001929","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR033C"}


id: YFR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PHO4","product":"Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p; function is regulated by phosphorylation at multiple sites and by phosphate availability","secondary_identifier":"SGD:S000001930","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR034C"}


id: YFR034W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps YFR035C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR034W-A"}


id: YFR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; deletion mutant exhibits synthetic phenotype with alpha-synuclein","secondary_identifier":"SGD:S000001931","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR035C"}


id: YFR035W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; added to genome annotation based on evolutionary, translation, and proteomics evidence","secondary_identifier":"SGD:S000350095","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR035W-A"}


id: YFR036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01801":null,"YFR036W":null},"has_protein_features":false,"name":"CDC26","ortholog_annotations":[{"gene_uniquename":"YFR036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01801","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001932","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR036W"}


id: YFR036W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps verified ORF RSC8/YFR037C","secondary_identifier":"SGD:S000028767","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR036W-A"}


id: YFR037C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02589":null,"YFR037C":null},"has_protein_features":false,"name":"RSC8","ortholog_annotations":[{"gene_uniquename":"YFR037C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02589","reference_uniquename":"PMID:29761456"}],"product":"Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001933","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR037C"}


id: YFR038W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC5","product":"Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci; SWAT-GFP and mCherry fusion proteins localize to the nucleus","secondary_identifier":"SGD:S000001934","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR038W"}


id: YFR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OSW7","product":"Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; may be involved in response to high salt and changes in carbon source; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; deletion mutant has decreased spore survival in Drosophila feces; OSW7 has a paralog, SHE10, that arose from the whole genome duplication; paralogs are redundant for spore wall dityrosine assembly","secondary_identifier":"SGD:S000001935","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR039C"}


id: YFR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04638":null,"YFR040W":null},"has_protein_features":false,"name":"SAP155","ortholog_annotations":[{"gene_uniquename":"YFR040W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04638","reference_uniquename":"PMID:29761456"}],"product":"Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress; SAP155 has a paralog, SAP4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001936","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR040W"}


id: YFR041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03030":null,"YFR041C":null},"has_protein_features":false,"name":"ERJ5","ortholog_annotations":[{"gene_uniquename":"YFR041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03030","reference_uniquename":"PMID:29761456"}],"product":"Type I membrane protein with a J domain; required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001937","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR041C"}


id: YFR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"KEG1","product":"Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability","secondary_identifier":"SGD:S000001938","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR042W"}


id: YFR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05011":null,"YFR043C":null},"has_protein_features":false,"name":"IRC6","ortholog_annotations":[{"gene_uniquename":"YFR043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05011","reference_uniquename":"PMID:29761456"}],"product":"Clathrin coat accessory factor; involved in clathrin-mediated vesicle trafficking; may function to link the AP-1 clathrin adaptor complex with the Rab GTPase Ypt31p; has structural similarity to G-proteins; mouse homolog Aagab (p34) functionally complements irc6 null mutation; null mutant displays increased levels of spontaneous Rad52p foci","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001939","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR043C"}


id: YFR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04858":null,"YFR044C":null},"has_protein_features":false,"name":"DUG1","ortholog_annotations":[{"gene_uniquename":"YFR044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04858","reference_uniquename":"PMID:29761456"}],"product":"Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); human homolog CNDP2 can complement yeast dug1 mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001940","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR044C"}


id: YFR045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRX20","product":"Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white","secondary_identifier":"SGD:S000001941","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR045W"}


id: YFR046C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02513":null,"YFR046C":null},"has_protein_features":false,"name":"CNN1","ortholog_annotations":[{"gene_uniquename":"YFR046C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02513","reference_uniquename":"PMID:29761456"}],"product":"Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001942","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR046C"}


id: YFR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BNA6","product":"Quinolinate phosphoribosyl transferase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p","secondary_identifier":"SGD:S000001943","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR047C"}


id: YFR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01174":null,"SJAG_02548":null,"YFR048W":null},"has_protein_features":false,"name":"RMD8","ortholog_annotations":[{"gene_uniquename":"YFR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01174","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YFR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02548","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic protein required for sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001944","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR048W"}


id: YFR049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06382":null,"YFR049W":null},"has_protein_features":false,"name":"KGD4","ortholog_annotations":[{"gene_uniquename":"YFR049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06382","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase; recruits E3 subunit (Lpd1p) to the E1-E2 (Kgd1p, Kgd2p) core; exists in two forms derived from a single mRNA translated from two alternative start sites; evolutionarily conserved role in the organization of mitochondrial α-KGDH complexes; homolog of human KGD4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001945","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR049W"}


id: YFR050C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04541":null,"YFR050C":null},"has_protein_features":false,"name":"PRE4","ortholog_annotations":[{"gene_uniquename":"YFR050C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04541","reference_uniquename":"PMID:29761456"}],"product":"Beta 7 subunit of the 20S proteasome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001946","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR050C"}


id: YFR051C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02482":null,"YFR051C":null},"has_protein_features":false,"name":"RET2","ortholog_annotations":[{"gene_uniquename":"YFR051C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02482","reference_uniquename":"PMID:29761456"}],"product":"Delta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001947","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR051C"}


id: YFR052C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF HXK1/YFR053C","secondary_identifier":"SGD:S000028768","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR052C-A"}


id: YFR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01203":null,"YFR052W":null},"has_protein_features":false,"name":"RPN12","ortholog_annotations":[{"gene_uniquename":"YFR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01203","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001948","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR052W"}


id: YFR053C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04334":null,"YFR053C":null},"has_protein_features":false,"name":"HXK1","ortholog_annotations":[{"gene_uniquename":"YFR053C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04334","reference_uniquename":"PMID:29761456"}],"product":"Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001949","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR053C"}


id: YFR054C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000001950","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR054C"}


id: YFR055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC7","product":"Cysteine desulphydrase, enables growth on cysteine as nitrogen source; involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner","secondary_identifier":"SGD:S000001952","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR055W"}


id: YFR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W","secondary_identifier":"SGD:S000001951","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR056C"}


id: YFR057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Telomere-linked gene, silencing of which is strictly Sir2-dependent","secondary_identifier":"SGD:S000001953","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YFR057W"}


id: YGL001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02855":null,"YGL001C":null},"has_protein_features":false,"name":"ERG26","ortholog_annotations":[{"gene_uniquename":"YGL001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02855","reference_uniquename":"PMID:29761456"}],"product":"C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; human homolog NSDHL implicated in CK syndrome, and can complement yeast null mutant; molecular target of natural product and antifungal compound FR171456","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002969","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL001C"}


id: YGL002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04598":null,"YGL002W":null},"has_protein_features":false,"name":"ERP6","ortholog_annotations":[{"gene_uniquename":"YGL002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04598","reference_uniquename":"PMID:29761456"}],"product":"Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002970","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL002W"}


id: YGL003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00071":null,"SJAG_04853":null,"YGL003C":null},"has_protein_features":false,"name":"CDH1","ortholog_annotations":[{"gene_uniquename":"YGL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00071","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL003C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04853","reference_uniquename":"PMID:29761456"}],"product":"Activator of anaphase-promoting complex/cyclosome (APC/C); antagonist of the spindle assembly checkpoint; directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including: Cdc20p, Ase1p, Cin8p, Fin1p and Clb5p; partially active in metaphase, and fully active in anaphase; cell-cycle regulated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002971","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL003C"}


id: YGL004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RPN14","product":"Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p","secondary_identifier":"SGD:S000002972","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL004C"}


id: YGL005C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"COG7","product":"Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments","secondary_identifier":"SGD:S000002973","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL005C"}


id: YGL006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01400":null,"YGL006W":null},"has_protein_features":false,"name":"PMC1","ortholog_annotations":[{"gene_uniquename":"YGL006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01400","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in presence of elevated concentrations of calcium; targeted to vacuole via AP-3 pathway; similar to mammalian PMCA1a","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002974","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL006W"}


id: YGL006W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by SAGE","secondary_identifier":"SGD:S000028769","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL006W-A"}


id: YGL007C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding","secondary_identifier":"SGD:S000028632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL007C-A"}


id: YGL007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BRP1","product":"Putative protein of unknown function; located in the upstream region of PMA1; conserved among S. cerevisiae strains; mediates the cycloheximide-induced degradation of ubiquitinated Agp2p, a regulator of high affinity polyamine and carnitine transport; null mutant is polyamine resistant due to downregulation of PMA1","secondary_identifier":"SGD:S000002975","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL007W"}


id: YGL008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01129":null,"SJAG_01669":null,"SJAG_04258":null,"YGL008C":null},"has_protein_features":false,"name":"PMA1","ortholog_annotations":[{"gene_uniquename":"YGL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01129","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01669","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YGL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04258","reference_uniquename":"PMID:26896847"}],"product":"Plasma membrane P2-type H+-ATPase; pumps protons out of cell; major regulator of cytoplasmic pH and plasma membrane potential; long-lived hexameric protein asymmetrically distributed at plasma membrane between mother cells and buds; accumulates at high levels in mother cells during aging, buds emerge with very low levels of Pma1p, newborn cells have low levels of Pma1p; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000002976","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL008C"}


id: YGL009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03243":null,"YGL009C":null},"has_protein_features":false,"name":"LEU1","ortholog_annotations":[{"gene_uniquename":"YGL009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03243","reference_uniquename":"PMID:29761456"}],"product":"Isopropylmalate isomerase; catalyzes the second step in the leucine biosynthesis pathway","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002977","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL009C"}


id: YGL010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00519":null,"YGL010W":null},"has_protein_features":false,"name":"MPO1","ortholog_annotations":[{"gene_uniquename":"YGL010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00519","reference_uniquename":"PMID:29761456"}],"product":"Dioxygenase that catalyzes alpha-oxygenation of 2-hydroxy fatty acids; involved in metabolism of phytosphingosine; not an essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002978","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL010W"}


id: YGL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02562":null,"YGL011C":null},"has_protein_features":false,"name":"SCL1","ortholog_annotations":[{"gene_uniquename":"YGL011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02562","reference_uniquename":"PMID:29761456"}],"product":"Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002979","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL011C"}


id: YGL012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03024":null,"YGL012W":null},"has_protein_features":false,"name":"ERG4","ortholog_annotations":[{"gene_uniquename":"YGL012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03024","reference_uniquename":"PMID:29761456"}],"product":"C-24(28) sterol reductase; catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000002980","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL012W"}


id: YGL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PDR1","product":"Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; relocalizes to the cytosol in response to hypoxia; PDR1 has a paralog, PDR3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000002981","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YGL013C"}


