# genes

id: YIL099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02076":null,"YIL099W":null},"has_protein_features":false,"name":"SGA1","ortholog_annotations":[{"gene_uniquename":"YIL099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02076","reference_uniquename":"PMID:29761456"}],"product":"Intracellular sporulation-specific glucoamylase; involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001361","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL099W"}


id: YIL100C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000028794","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL100C-A"}


id: YIL100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A","secondary_identifier":"SGD:S000001362","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL100W"}


id: YIL101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"XBP1","product":"Transcriptional repressor; binds promoter sequences of cyclin genes, CYS3, and SMF2; not expressed during log phase of growth, but induced by stress or starvation during mitosis, and late in meiosis; represses 15% of all yeast genes as cells transition to quiescence; important for maintaining G1 arrest and for longevity of quiescent cells; member of Swi4p/Mbp1p family; phosphorylated by Cdc28p; relative distribution to nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000001363","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL101C"}


id: YIL102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001364","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL102C"}


id: YIL102C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05219":null,"YIL102C-A":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YIL102C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05219","reference_uniquename":"PMID:29761456"}],"product":"Regulatory subunit of dolichyl phosphate mannose (DPM) synthase; identified based on comparisons of the genome sequences of six Saccharomyces species; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000113587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL102C-A"}


id: YIL103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01058":null,"YIL103W":null},"has_protein_features":false,"name":"DPH1","ortholog_annotations":[{"gene_uniquename":"YIL103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01058","reference_uniquename":"PMID:29761456"}],"product":"Protein required for synthesis of diphthamide; required along with Dph2p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); forms a complex with Dph2p that catalyzes the first step of diphthamide biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001365","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL103W"}


id: YIL104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03551":null,"YIL104C":null},"has_protein_features":false,"name":"SHQ1","ortholog_annotations":[{"gene_uniquename":"YIL104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03551","reference_uniquename":"PMID:29761456"}],"product":"Chaperone protein; required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing; functions as an RNA mimic; forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001366","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL104C"}


id: YIL105C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02989":null,"YIL105C":null},"has_protein_features":false,"name":"SLM1","ortholog_annotations":[{"gene_uniquename":"YIL105C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02989","reference_uniquename":"PMID:29761456"}],"product":"Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; TORC2 complex substrate and effector; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001367","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL105C"}


id: YIL105W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; completely overlaps the verified gene SLM1; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; mRNA identified as translated by ribosome profiling data","secondary_identifier":"SGD:S000028657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL105W-A"}


id: YIL106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03936":null,"YIL106W":null},"has_protein_features":false,"name":"MOB1","ortholog_annotations":[{"gene_uniquename":"YIL106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03936","reference_uniquename":"PMID:29761456"}],"product":"Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001368","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL106W"}


id: YIL107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02596":null,"SJAG_03336":null,"YIL107C":null},"has_protein_features":false,"name":"PFK26","ortholog_annotations":[{"gene_uniquename":"YIL107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02596","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03336","reference_uniquename":"PMID:29761456"}],"product":"6-phosphofructo-2-kinase; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001369","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL107C"}


id: YIL108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03407":null,"YIL108W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YIL108W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03407","reference_uniquename":"PMID:29761456"}],"product":"Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001370","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL108W"}


id: YIL109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00072":null,"YIL109C":null},"has_protein_features":false,"name":"SEC24","ortholog_annotations":[{"gene_uniquename":"YIL109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00072","reference_uniquename":"PMID:29761456"}],"product":"Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SEC24 has a paralog, SFB2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001371","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL109C"}


id: YIL110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02868":null,"YIL110W":null},"has_protein_features":false,"name":"HPM1","ortholog_annotations":[{"gene_uniquename":"YIL110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02868","reference_uniquename":"PMID:29761456"}],"product":"AdoMet-dependent methyltransferase; involved in a novel 3-methylhistidine modification of multiple proteins, including ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001372","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL110W"}


id: YIL111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01077":null,"YIL111W":null},"has_protein_features":false,"name":"COX5B","ortholog_annotations":[{"gene_uniquename":"YIL111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01077","reference_uniquename":"PMID:29761456"}],"product":"Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001373","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL111W"}


id: YIL112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HOS4","product":"Subunit of the Set3 complex; complex is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate","secondary_identifier":"SGD:S000001374","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL112W"}


id: YIL113W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03263":null,"YIL113W":null},"has_protein_features":false,"name":"SDP1","ortholog_annotations":[{"gene_uniquename":"YIL113W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03263","reference_uniquename":"PMID:29761456"}],"product":"Stress-inducible dual-specificity MAP kinase phosphatase; negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock; SDP1 has a paralog, MSG5, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001375","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL113W"}


id: YIL114C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00048":null,"YIL114C":null},"has_protein_features":false,"name":"POR2","ortholog_annotations":[{"gene_uniquename":"YIL114C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00048","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001376","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL114C"}


id: YIL115C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01013":null,"YIL115C":null},"has_protein_features":false,"name":"NUP159","ortholog_annotations":[{"gene_uniquename":"YIL115C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01013","reference_uniquename":"PMID:29761456"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001377","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL115C"}


id: YIL115W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUP159/YIL115C","secondary_identifier":"SGD:S000028795","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL115W-A"}


id: YIL116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03055":null,"YIL116W":null},"has_protein_features":false,"name":"HIS5","ortholog_annotations":[{"gene_uniquename":"YIL116W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03055","reference_uniquename":"PMID:29761456"}],"product":"Histidinol-phosphate aminotransferase; catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001378","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL116W"}


id: YIL117C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRM5","product":"Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling; PRM5 has a paralog, YNL058C, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001379","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL117C"}


id: YIL118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02366":null,"YIL118W":null},"has_protein_features":false,"name":"RHO3","ortholog_annotations":[{"gene_uniquename":"YIL118W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02366","reference_uniquename":"PMID:29761456"}],"product":"Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001380","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL118W"}


id: YIL119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RPI1","product":"Transcription factor, allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF","secondary_identifier":"SGD:S000001381","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL119C"}


id: YIL120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"QDR1","product":"Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in spore wall assembly; sequence similarity to DTR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001382","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL120W"}


id: YIL121W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"QDR2","product":"Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper","secondary_identifier":"SGD:S000001383","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL121W"}


id: YIL122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"POG1","product":"DNA-binding transcriptional activator; involved in cell cycle regulation; overexpression promotes recovery from pheromone induced arrest via CLN1/2 transcription, induction of of IME1 during sporulation, and suppression of stress sensitivity resulting from mutation of the E3 ubiquitin ligase Rsp5p; binds upstream of BAR1 and cell cycle-related genes; phosphorylated form may be ubiquitinated by Dma2p; potential Cdc28p substrate; regulated by Swi4/6 cell-cycle box binding factor (SBF)","secondary_identifier":"SGD:S000001384","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL122W"}


id: YIL123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02649":null,"SJAG_03295":null,"YIL123W":null},"has_protein_features":false,"name":"SIM1","ortholog_annotations":[{"gene_uniquename":"YIL123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02649","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03295","reference_uniquename":"PMID:29761456"}],"product":"Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p); may participate in DNA replication; promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated; SIM1 has a paralog, SUN4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001385","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL123W"}


id: YIL124W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01036":null,"YIL124W":null},"has_protein_features":false,"name":"AYR1","ortholog_annotations":[{"gene_uniquename":"YIL124W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01036","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional triacylglycerol lipase and 1-acyl DHAP reductase; NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase involved in phosphatidic acid biosynthesis; lipid droplet triacylglycerol lipase involved in mobilization of non-polar lipids; found in lipid particles, endoplasmic reticulum and mitochondrial outer membrane; forms NADPH-regulated channel in mitochondrial outer membrane; required for spore germination; role in cell wall biosynthesis; capable of metabolizing steroid hormones","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001386","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL124W"}


id: YIL125W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02464":null,"YIL125W":null},"has_protein_features":false,"name":"KGD1","ortholog_annotations":[{"gene_uniquename":"YIL125W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02464","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex; catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001387","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL125W"}


id: YIL126W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04755":null,"SJAG_05313":null,"YIL126W":null},"has_protein_features":false,"name":"STH1","ortholog_annotations":[{"gene_uniquename":"YIL126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04755","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05313","reference_uniquename":"PMID:29761456"}],"product":"ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; promotes base excision repair in chromatin; essential helicase-related protein homologous to Snf2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001388","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL126W"}


id: YIL127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RRT14","product":"Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis","secondary_identifier":"SGD:S000001389","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL127C"}


id: YIL128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02866":null,"YIL128W":null},"has_protein_features":false,"name":"MET18","ortholog_annotations":[{"gene_uniquename":"YIL128W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02866","reference_uniquename":"PMID:29761456"}],"product":"Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation and maturation of a subset of cytosolic and nuclear proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001390","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL128W"}


id: YIL129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03637":null,"YIL129C":null},"has_protein_features":false,"name":"TAO3","ortholog_annotations":[{"gene_uniquename":"YIL129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03637","reference_uniquename":"PMID:29761456"}],"product":"Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001391","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL129C"}


id: YIL130W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05343":null,"YIL130W":null},"has_protein_features":false,"name":"ASG1","ortholog_annotations":[{"gene_uniquename":"YIL130W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05343","reference_uniquename":"PMID:29761456"}],"product":"Zinc cluster protein proposed to be a transcriptional regulator; regulator involved in the stress response; regulates utilization of fatty acids and accumulation of lipids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001392","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL130W"}


id: YIL131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04813":null,"YIL131C":null},"has_protein_features":false,"name":"FKH1","ortholog_annotations":[{"gene_uniquename":"YIL131C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04813","reference_uniquename":"PMID:29761456"}],"product":"Forkhead family transcription factor; rate-limiting replication origin activator; evolutionarily conserved lifespan regulator; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; regulates transcription elongation, chromatin silencing at mating loci, expression of G2/M phase genes; facilitates clustering, activation of early-firing replication origins; binds HML recombination enhancer, regulates donor preference during mating-type switching","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001393","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL131C"}


id: YIL132C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSM2","product":"Subunit of the Shu complex (aka PCSS complex); Shu complex also includes Psy3, Shu1, Shu2, and promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p anti-recombinase function; promotes formation of Rad51p filaments; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis","secondary_identifier":"SGD:S000001394","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL132C"}


id: YIL133C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02207":null,"SJAG_04160":null,"YIL133C":null},"has_protein_features":false,"name":"RPL16A","ortholog_annotations":[{"gene_uniquename":"YIL133C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02207","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL133C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04160","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001395","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL133C"}


id: YIL134C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by fungal homology and RT-PCR","secondary_identifier":"SGD:S000028556","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL134C-A"}


id: YIL134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03503":null,"YIL134W":null},"has_protein_features":false,"name":"FLX1","ortholog_annotations":[{"gene_uniquename":"YIL134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03503","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial flavin adenine dinucleotide transporter; FAD is a synthesis product of riboflavin; human homolog SLC25A32 is implicated in multiple acyl-CoA dehydrogenase deficiency (MADD) or glutaric aciduria type II (GAII), and can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001396","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL134W"}


id: YIL135C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VHS2","product":"Regulator of septin dynamics; involved in the regulation of septin dynamics at bud neck after mitotic entry, likely by stabilizing septin structure; regulated at post-translational level by cell cycle dependent phosphorylation; likely phosphorylated by Cdc28p and dephosphorylated by Cdc14p before cytokinesis; high-copy suppressor of synthetic lethality of sis2 sit4 double mutant; VHS2 has a paralog, MLF3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001397","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL135C"}


id: YIL136W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"OM45","product":"Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, extending into the intermembrane space; interacts with porin (Por1p) and with Om14p; imported via the presequence pathway involving the TOM and TIM23 complexes, then assembled in the outer membrane by Mim1p; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000001398","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL136W"}


id: YIL137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00181":null,"YIL137C":null},"has_protein_features":false,"name":"TMA108","ortholog_annotations":[{"gene_uniquename":"YIL137C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00181","reference_uniquename":"PMID:29761456"}],"product":"Ribosome-associated, nascent chain binding factor; binds N-terminal region of nascent peptides during translation; recognizes target proteins via its putative metallopeptidase peptide-binding pocket","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001399","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL137C"}


id: YIL138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04887":null,"YIL138C":null},"has_protein_features":false,"name":"TPM2","ortholog_annotations":[{"gene_uniquename":"YIL138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04887","reference_uniquename":"PMID:29761456"}],"product":"Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001400","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL138C"}


id: YIL139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00611":null,"YIL139C":null},"has_protein_features":false,"name":"REV7","ortholog_annotations":[{"gene_uniquename":"YIL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00611","reference_uniquename":"PMID:29761456"}],"product":"Accessory subunit of DNA polymerase zeta (pol zeta); involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; may be involved in meiosis; forms a complex with Rev3p, Pol31p and Pol32p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001401","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL139C"}


id: YIL140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AXL2","product":"Integral plasma membrane protein; required for axial budding in haploid cells; localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate","secondary_identifier":"SGD:S000001402","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL140W"}


id: YIL141W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001403","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL141W"}


id: YIL142C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF CCT2/YIL142W","secondary_identifier":"SGD:S000028796","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL142C-A"}


id: YIL142W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01002":null,"YIL142W":null},"has_protein_features":false,"name":"CCT2","ortholog_annotations":[{"gene_uniquename":"YIL142W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01002","reference_uniquename":"PMID:29761456"}],"product":"Subunit beta of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001404","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL142W"}


id: YIL143C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03206":null,"YIL143C":null},"has_protein_features":false,"name":"SSL2","ortholog_annotations":[{"gene_uniquename":"YIL143C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03206","reference_uniquename":"PMID:29761456"}],"product":"Component of RNA polymerase transcription factor TFIIH holoenzyme; acts as dsDNA-dependent translocase in context of TFIIH, unwinds DNA strands during initiation and promotes transcription start site (TSS) scanning; has DNA-dependent ATPase/helicase activity; interacts functionally with TFIIB, has roles in TSS selection and gene looping to juxtapose initiation and termination regions; involved in DNA repair; relocalizes to cytosol under hypoxia; homolog of human ERCC3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001405","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL143C"}


id: YIL144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04076":null,"YIL144W":null},"has_protein_features":false,"name":"NDC80","ortholog_annotations":[{"gene_uniquename":"YIL144W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04076","reference_uniquename":"PMID:29761456"}],"product":"Component of the kinetochore-associated Ndc80 complex; conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, and kinetochore assembly and clustering; evolutionarily conserved; complex members include Ndc80p, Nuf2p, Scp24p, and Spc25p; modified by sumoylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001406","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL144W"}


id: YIL145C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03679":null,"YIL145C":null},"has_protein_features":false,"name":"PAN6","ortholog_annotations":[{"gene_uniquename":"YIL145C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03679","reference_uniquename":"PMID:29761456"}],"product":"Pantothenate synthase; also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001407","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL145C"}


id: YIL146C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG32","product":"Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane; regulates mitophagy and ethanol production during alcoholic fermentation","secondary_identifier":"SGD:S000001408","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL146C"}


id: YIL147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00331":null,"SJAG_01587":null,"SJAG_02183":null,"YIL147C":null},"has_protein_features":false,"name":"SLN1","ortholog_annotations":[{"gene_uniquename":"YIL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00331","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01587","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL147C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02183","reference_uniquename":"PMID:29761456"}],"product":"Transmembrane histidine phosphotransfer kinase and osmosensor; regulates MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001409","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL147C"}


id: YIL148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01365":null,"SJAG_02891":null,"SJAG_03971":null,"YIL148W":null},"has_protein_features":false,"name":"RPL40A","ortholog_annotations":[{"gene_uniquename":"YIL148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01365","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02891","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIL148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03971","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001410","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL148W"}


id: YIL149C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03300":null,"SJAG_04645":null,"YIL149C":null},"has_protein_features":false,"name":"MLP2","ortholog_annotations":[{"gene_uniquename":"YIL149C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03300","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YIL149C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04645","reference_uniquename":"PMID:29761456"}],"product":"Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; MLP2 has a paralog, MLP1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001411","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL149C"}


id: YIL150C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00399":null,"YIL150C":null},"has_protein_features":false,"name":"MCM10","ortholog_annotations":[{"gene_uniquename":"YIL150C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00399","reference_uniquename":"PMID:29761456"}],"product":"Essential chromatin-associated protein; involved in initiation of DNA replication; promotes origin duplex unwinding by head-to-head CMG helicase complexes; required for association of MCM2-7 complex with replication origins; required to stabilize the catalytic subunit of DNA polymerase-alpha; coordinates function of the replication fork helicase; self-associates through its N-terminal domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001412","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL150C"}


id: YIL151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01720":null,"YIL151C":null},"has_protein_features":false,"name":"ESL1","ortholog_annotations":[{"gene_uniquename":"YIL151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01720","reference_uniquename":"PMID:29761456"}],"product":"hEST1A/B (SMG5/6)-like protein; contributes to environment-sensing adaptive gene expression responses; Esl1p and Esl2p contain a 14-3-3-like domain and a putative PilT N-terminus ribonuclease domain; ESL1 has a paralog, ESL2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001413","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL151C"}


id: YIL152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VPR1","product":"Putative protein of unknown function","secondary_identifier":"SGD:S000001414","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL152W"}


id: YIL153W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01270":null,"YIL153W":null},"has_protein_features":false,"name":"RRD1","ortholog_annotations":[{"gene_uniquename":"YIL153W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01270","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001415","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL153W"}


id: YIL154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IMP21","product":"Transcriptional activator involved in maintenance of ion homeostasis; also involved in protection against DNA damage caused by bleomycin and other oxidants; contains a C-terminal leucine-rich repeat","secondary_identifier":"SGD:S000001416","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL154C"}


id: YIL155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GUT2","product":"Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner","secondary_identifier":"SGD:S000001417","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL155C"}


id: YIL156W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00742":null,"YIL156W":null},"has_protein_features":false,"name":"UBP7","ortholog_annotations":[{"gene_uniquename":"YIL156W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00742","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; involved in cell cycle progression through S phase; UBP7 has a paralog, UBP11, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001418","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL156W"}


id: YIL156W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF COA1/YIL157C","secondary_identifier":"SGD:S000028797","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL156W-A"}


id: YIL156W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05261":null,"YIL156W-B":null},"has_protein_features":false,"name":"ATG44","ortholog_annotations":[{"gene_uniquename":"YIL156W-B","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05261","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial fission factor (mitofissin) essential for mitophagy; required for Dmn1p-mediated mitochondrial fission; directly binds to lipid membranes and brings about lipid membrane fragility to facilitate membrane fission; S. pombe homolog complements null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028511","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL156W-B"}


id: YIL157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04603":null,"YIL157C":null},"has_protein_features":false,"name":"COA1","ortholog_annotations":[{"gene_uniquename":"YIL157C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04603","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein; required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001419","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL157C"}


id: YIL158W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM20","product":"Protein of unknown function; overexpression causes cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress; AIM20 has a paralog, SKG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001420","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL158W"}


id: YIL159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00279":null,"SJAG_01943":null,"YIL159W":null},"has_protein_features":false,"name":"BNR1","ortholog_annotations":[{"gene_uniquename":"YIL159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00279","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YIL159W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01943","reference_uniquename":"PMID:29761456"}],"product":"Formin; nucleates the formation of linear actin filaments; involved in processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables; activity is regulated by Hof1p and by the Bud14p-Kel1p-Kel2p complex; dephosphorylated and delocalized from the division site in a Glc7p/Ref2p-dependent manner; functionally redundant with BNI1","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001421","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL159W"}


id: YIL160C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"POT1","product":"3-ketoacyl-CoA thiolase with broad chain length specificity; cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids","secondary_identifier":"SGD:S000001422","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL160C"}


id: YIL161W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SMU2","product":"Protein involved in removal of stalled ribosomes; acts as cofactor for Fap1p and Fpr1p in ubiquitination of stalled monosomes and subsequent degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene","secondary_identifier":"SGD:S000001423","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL161W"}


id: YIL162W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04301":null,"YIL162W":null},"has_protein_features":false,"name":"SUC2","ortholog_annotations":[{"gene_uniquename":"YIL162W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04301","reference_uniquename":"PMID:29761456"}],"product":"Invertase; sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001424","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL162W"}


id: YIL163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data","secondary_identifier":"SGD:S000001425","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL163C"}


id: YIL164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"NIT1","product":"Nitrilase; member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene","secondary_identifier":"SGD:S000001426","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL164C"}


id: YIL165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene","secondary_identifier":"SGD:S000001427","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL165C"}


id: YIL166C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SOA1","product":"Sulfonate and inorganic sulfur transporter; low affinity sulfate, high affinity sulfite, thiosulfite and major sulfonate transporter; functions as a an H+ symporter; similar to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; non-essential gene","secondary_identifier":"SGD:S000001428","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL166C"}


id: YIL167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SDL1","product":"Blocked reading frame otherwise encoding L-serine dehydratase","secondary_identifier":"SGD:S000001429","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL167W"}


id: YIL169C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CSS1","product":"Protein of unknown function, secreted when constitutively expressed; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cell periphery, SWAT-GFP fusion also localizes to the extracellular region, and mCherry fusion also localizes to the vacuole; S/T rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; non-essential gene","secondary_identifier":"SGD:S000001431","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL169C"}


id: YIL171W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF IMA3/YIL172C","secondary_identifier":"SGD:S000028798","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL171W-A"}


id: YIL172C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IMA3","product":"Alpha-glucosidase; weak, but broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima3p overexpression allows the ima1 null mutant to grow on isomaltose; lower activitiy and thermostability in vitro than Ima2p despite sequence difference of only 3 amino acids; cleaves alpha-1,3 linkage of nigerose and turanose, but not alpha-1,5 of leucrose; identical to IMA4","secondary_identifier":"SGD:S000001434","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL172C"}


id: YIL173W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01488":null,"YIL173W":null},"has_protein_features":false,"name":"VTH1","ortholog_annotations":[{"gene_uniquename":"YIL173W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01488","reference_uniquename":"PMID:29761456"}],"product":"Putative membrane glycoprotein; has strong similarity to Vth2p and Pep1p/Vps10p; may be involved in vacuolar protein sorting","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001435","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL173W"}


id: YIL176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU14","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau1p","secondary_identifier":"SGD:S000001438","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL176C"}


id: YIL177C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative Y' element ATP-dependent helicase","secondary_identifier":"SGD:S000001439","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL177C"}


id: YIL177W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YIL177C","secondary_identifier":"SGD:S000028658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIL177W-A"}


id: YIR001C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04601":null,"YIR001C":null},"has_protein_features":false,"name":"SGN1","ortholog_annotations":[{"gene_uniquename":"YIR001C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04601","reference_uniquename":"PMID:29761456"}],"product":"Cytoplasmic RNA-binding protein; contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001440","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR001C"}


id: YIR002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02294":null,"SJAG_02690":null,"YIR002C":null},"has_protein_features":false,"name":"MPH1","ortholog_annotations":[{"gene_uniquename":"YIR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02294","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02690","reference_uniquename":"PMID:29761456"}],"product":"3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds flap DNA, stimulates activity of Rad27p and Dna2p; prevents crossovers between ectopic sequences by removing substrates for Mus81-Mms4 or Rad1-Rad10 cleavage; homolog of human FANCM Fanconi anemia protein that is involved in stabilizing and remodeling blocked replication forks; member of SF2 DExD/H superfamily of helicases; nonsense or missense mutations in FANCM predispose  individuals to breast cancer","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001441","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR002C"}


id: YIR003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04172":null,"YIR003W":null},"has_protein_features":false,"name":"AIM21","ortholog_annotations":[{"gene_uniquename":"YIR003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04172","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a complex that associates with actin filaments; forms a complex with Tda2p that inhibits barbed end F-actin assembly; elevates actin monomer pools to increase endocytotic efficiency and to regulate the distribution of actin between cables and patches; Aim21p/Tda2p forms a larger complex with actin capping proteins Cap1p and Cap2p; involved in mitochondrial migration along actin filaments; recruited to cortical actin patches by SH3 domain-containing proteins Bbc1p and Abp1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001442","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR003W"}


id: YIR004W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02034":null,"SJAG_02797":null,"YIR004W":null},"has_protein_features":false,"name":"DJP1","ortholog_annotations":[{"gene_uniquename":"YIR004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02034","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR004W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02797","reference_uniquename":"PMID:29761456"}],"product":"ER-associated chaperone involved in protein targeting; redirects mitochondrial membrane protein precursors to mitochondrial translocation system; required for peroxisomal protein import and involved in peroxisome assembly; facilitates import of Mim1p and Mim2p into the mitochondrial outer membrane; homologous to E. coli DnaJ","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001443","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR004W"}


id: YIR005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00313":null,"YIR005W":null},"has_protein_features":false,"name":"IST3","ortholog_annotations":[{"gene_uniquename":"YIR005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00313","reference_uniquename":"PMID:29761456"}],"product":"Component of the U2 snRNP; required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing; diploid mutants have a specific defect in MATa1 pre-mRNA splicing which leads to haploid gene expression in diploids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001444","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR005W"}


id: YIR006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04886":null,"YIR006C":null},"has_protein_features":false,"name":"PAN1","ortholog_annotations":[{"gene_uniquename":"YIR006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04886","reference_uniquename":"PMID:29761456"}],"product":"Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p; associates with actin patches on cell cortex; promotes protein-protein interactions essential for endocytosis; regulates late stages of endocytosis; binds to and activates Arp2/3 complex in vitro; phosphorylation of Thr-1225 is regulated by MAPK Hog1p in response to osmotic stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001445","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR006C"}


id: YIR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"EGH1","product":"Steryl-beta-glucosidase with broad specificity for aglycones; has a role in ergosteryl-beta-glucoside catabolism; required for normal vacuolar morphology; has similarity to the C. neoformans ergosteryl-beta-glucosidase EGCrP2; localizes to the cytosol","secondary_identifier":"SGD:S000001446","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR007W"}


id: YIR008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04994":null,"YIR008C":null},"has_protein_features":false,"name":"PRI1","ortholog_annotations":[{"gene_uniquename":"YIR008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04994","reference_uniquename":"PMID:29761456"}],"product":"Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001447","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR008C"}


id: YIR009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03547":null,"YIR009W":null},"has_protein_features":false,"name":"MSL1","ortholog_annotations":[{"gene_uniquename":"YIR009W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03547","reference_uniquename":"PMID:29761456"}],"product":"U2B component of U2 snRNP; involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001448","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR009W"}


id: YIR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02346":null,"YIR010W":null},"has_protein_features":false,"name":"DSN1","ortholog_annotations":[{"gene_uniquename":"YIR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02346","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the outer kinetochore MIND complex; joins kinetochore subunits contacting DNA to those contacting microtubules; phosphorylation promotes interaction between outer and inner kinetochore proteins; kinetochore receptor for monopolin, via interaction with Csm1p; essential for both meiotic and mitotic chromosome segregation; MIND complex consists of Mtw1p, Nnf1p, Nsl1p and Dsn1p; phosphorylated by monopolin subunit, Hrr25p and Aurora kinase, Ipl1p; modified by sumoylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001449","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR010W"}


id: YIR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00054":null,"YIR011C":null},"has_protein_features":false,"name":"STS1","ortholog_annotations":[{"gene_uniquename":"YIR011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00054","reference_uniquename":"PMID:29761456"}],"product":"Karyopherin adaptor required for nuclear translocation of the proteasome; mediates interaction between nuclear import factor Srp1p and the proteasome; nuclear import of the 26S proteasome is coupled to RanGTP-initiated, ubiquitin-independent proteasomal degradation of Sts1p; Sts1p and Srp1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation; role in ubiquitin-mediated protein degradation; contains a bipartite nuclear localization sequence","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001450","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR011C"}


id: YIR012W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02436":null,"YIR012W":null},"has_protein_features":false,"name":"SQT1","ortholog_annotations":[{"gene_uniquename":"YIR012W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02436","reference_uniquename":"PMID:29761456"}],"product":"Specific assembly chaperone for ribosomal protein Rpl10p; co-translationally associates with nascent Rpl10p, preventing aggregation; involved in biogenesis of the ribosomal large subunit; contains multiple WD repeats; interacts genetically and physically with Qsr1p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001451","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR012W"}


id: YIR013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GAT4","product":"Protein containing GATA family zinc finger motifs; involved in spore wall assembly; sequence similarity to GAT3, and the double mutant gat3 gat4 exhibits reduced dityrosine fluorescence relative to the single mutants","secondary_identifier":"SGD:S000001452","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR013C"}


id: YIR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"VLD1","product":"Component of Dsc E3 ligase complex in vacuolar membranes; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene","secondary_identifier":"SGD:S000001453","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR014W"}


id: YIR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00306":null,"YIR015W":null},"has_protein_features":false,"name":"RPR2","ortholog_annotations":[{"gene_uniquename":"YIR015W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00306","reference_uniquename":"PMID:29761456"}],"product":"Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; increases the activity and thermal stability of the complex, along with Pop2p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001454","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR015W"}


id: YIR016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001455","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR016W"}


id: YIR017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04749":null,"YIR017C":null},"has_protein_features":false,"name":"MET28","ortholog_annotations":[{"gene_uniquename":"YIR017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04749","reference_uniquename":"PMID:29761456"}],"product":"bZIP transcriptional activator in the Cbf1p-Met4p-Met28p complex; participates in the regulation of sulfur metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001456","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR017C"}


id: YIR017W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000028799","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR017W-A"}


id: YIR018C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028837","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR018C-A"}


id: YIR018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"YAP5","product":"Basic leucine zipper (bZIP) iron-sensing transcription factor; senses high-iron conditions via two Fe/S clusters bound to its activator domain; involved in diauxic shift; YAP5 has a paralog, YAP7, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001457","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR018W"}


id: YIR019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FLO11","product":"GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal and invasive growth, flocculation, and biofilm formation; major determinant of colony morphology; QTL that controls chronological life span; carries intragenic tandem repeats that are expanded in different strains; required for formation of fibrous interconnections between cells; role in co-flocculation with other yeast species; cleaved and shed from cells, contributing to their surface properties","secondary_identifier":"SGD:S000001458","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR019C"}


id: YIR020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data; SWAT-GFP fusion protein localizes to the endoplasmic reticulum","secondary_identifier":"SGD:S000001459","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR020C"}


id: YIR020C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF MRS1","secondary_identifier":"SGD:S000028800","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR020C-B"}


id: YIR020W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007241","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR020W-A"}


id: YIR021W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRS1","product":"Splicing protein; required for splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA; MRS1 has a paralog, CCE1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000001460","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR021W"}


id: YIR021W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by expression profiling and mass spectrometry","secondary_identifier":"SGD:S000028838","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR021W-A"}


id: YIR022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03261":null,"YIR022W":null},"has_protein_features":false,"name":"SEC11","ortholog_annotations":[{"gene_uniquename":"YIR022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03261","reference_uniquename":"PMID:29761456"}],"product":"18kDa catalytic subunit of the Signal Peptidase Complex (SPC); the Signal Peptidase Complex cleaves the signal sequence of proteins targeted to the endoplasmic reticulum; other members are Spc1p, Spc2p, Spc3p, and Sec11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001461","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR022W"}


id: YIR023C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF DAL81/YIR023W","secondary_identifier":"SGD:S000028801","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR023C-A"}


id: YIR023W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DAL81","product":"Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism","secondary_identifier":"SGD:S000001462","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR023W"}


id: YIR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"INA22","product":"F1F0 ATP synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex (Ina22p-Ina17p) involved in assembly of the F1F0 peripheral stalk; co-purifies with Aim43p, ATP synthase subunits, and cytochrome bc1 complex assembly factors; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect","secondary_identifier":"SGD:S000001463","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR024C"}


id: YIR025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03037":null,"YIR025W":null},"has_protein_features":false,"name":"MND2","ortholog_annotations":[{"gene_uniquename":"YIR025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03037","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001464","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR025W"}


id: YIR026C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01161":null,"YIR026C":null},"has_protein_features":false,"name":"YVH1","ortholog_annotations":[{"gene_uniquename":"YIR026C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01161","reference_uniquename":"PMID:29761456"}],"product":"Dual specificity protein phosphatase; regulates growth, sporulation, and glycogen accumulation in a cAMP-dependent protein kinase cascade dependent manner; mutants are defective in 60S ribosome assembly; positively regulates pre-autophagosomal structure (PAS) formation upon nitrogen starvation or rapamycin treatment","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001465","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR026C"}


id: YIR027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DAL1","product":"Allantoinase; converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression","secondary_identifier":"SGD:S000001466","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR027C"}


id: YIR028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02147":null,"SJAG_04714":null,"YIR028W":null},"has_protein_features":false,"name":"DAL4","ortholog_annotations":[{"gene_uniquename":"YIR028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02147","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YIR028W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04714","reference_uniquename":"PMID:29761456"}],"product":"Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000001467","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR028W"}


id: YIR029W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00035":null,"YIR029W":null},"has_protein_features":false,"name":"DAL2","ortholog_annotations":[{"gene_uniquename":"YIR029W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00035","reference_uniquename":"PMID:29761456"}],"product":"Allantoicase; converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001468","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR029W"}


id: YIR030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00036":null,"SJAG_04298":null,"YIR030C":null},"has_protein_features":false,"name":"DCG1","ortholog_annotations":[{"gene_uniquename":"YIR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00036","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR030C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04298","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001469","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR030C"}


id: YIR030W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF DAL7/YIR031C","secondary_identifier":"SGD:S000028802","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR030W-A"}


id: YIR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DAL7","product":"Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation","secondary_identifier":"SGD:S000001470","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR031C"}


id: YIR032C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05287":null,"YIR032C":null},"has_protein_features":false,"name":"DAL3","ortholog_annotations":[{"gene_uniquename":"YIR032C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05287","reference_uniquename":"PMID:29761456"}],"product":"Ureidoglycolate lyase; converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression is sensitive to nitrogen catabolite repression; this enzyme is sometimes referred to 'ureidoglycolate hydrolase' but should not be confused with the Arabidopsis thaliana ureidoglycolate hydrolase enzyme which converts ureidoglycolate to glyoxylate, ammonia and carbon dioxide","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001471","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR032C"}


id: YIR033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02196":null,"YIR033W":null},"has_protein_features":false,"name":"MGA2","ortholog_annotations":[{"gene_uniquename":"YIR033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02196","reference_uniquename":"PMID:29761456"}],"product":"ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; MGA2 has a paralog, SPT23, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001472","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR033W"}


id: YIR034C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02388":null,"YIR034C":null},"has_protein_features":false,"name":"LYS1","ortholog_annotations":[{"gene_uniquename":"YIR034C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02388","reference_uniquename":"PMID:29761456"}],"product":"Saccharopine dehydrogenase (NAD+, L-lysine-forming); catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; contains mRNA binding activity; required for targeting of Pls1p to the peroxisomal matrix in the absence of lysine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001473","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR034C"}


id: YIR035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03098":null,"YIR035C":null},"has_protein_features":false,"name":"NRE1","ortholog_annotations":[{"gene_uniquename":"YIR035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03098","reference_uniquename":"PMID:29761456"}],"product":"Benzil oxidoreductase with preference for NADPH; localizes to the cytoplasm; sequence similarity with short-chain dehydrogenase/reductases; putative paralog of IRC24","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001474","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR035C"}


id: YIR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03098":null,"YIR036C":null},"has_protein_features":false,"name":"IRC24","ortholog_annotations":[{"gene_uniquename":"YIR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03098","reference_uniquename":"PMID:29761456"}],"product":"Benzil oxidoreductase with preference for NADPH; localizes to the cytoplasm; induced by the DNA-damaging agent MMS; null mutant has elevated levels of spontaneous Rad52p foci; sequence similarity with short-chain dehydrogenase/reductases; putative paralog of IRC24","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001475","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR036C"}


id: YIR036W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF IRC24/YIR036C","secondary_identifier":"SGD:S000028803","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR036W-A"}


id: YIR037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01216":null,"YIR037W":null},"has_protein_features":false,"name":"HYR1","ortholog_annotations":[{"gene_uniquename":"YIR037W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01216","reference_uniquename":"PMID:29761456"}],"product":"Glutathione peroxidase; functions as hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce redox signal to Yap1p transcription factor; glutathione peroxidase activity is neuroprotective in models of Huntington's disease; HYR1 has a paralog, GPX1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001476","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR037W"}


id: YIR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05181":null,"YIR038C":null},"has_protein_features":false,"name":"GTT1","ortholog_annotations":[{"gene_uniquename":"YIR038C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05181","reference_uniquename":"PMID:29761456"}],"product":"ER associated glutathione S-transferase; capable of homodimerization; glutathione transferase for Yvc1p vacuolar cation channel; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001477","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR038C"}


id: YIR039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00109":null,"SJAG_00254":null,"SJAG_00784":null,"SJAG_02260":null,"YIR039C":null},"has_protein_features":false,"name":"YPS6","ortholog_annotations":[{"gene_uniquename":"YIR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00109","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00254","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00784","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YIR039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02260","reference_uniquename":"PMID:29761456"}],"product":"Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000001478","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR039C"}


id: YIR040C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000001479","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR040C"}


id: YIR041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU15","product":"Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole","secondary_identifier":"SGD:S000001480","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR041W"}


id: YIR042C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YIR042C is a non-essential gene","secondary_identifier":"SGD:S000001481","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR042C"}


id: YIR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Blocked reading frame; may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family","secondary_identifier":"SGD:S000001482","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YIR043C"}


id: YJL001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03151":null,"YJL001W":null},"has_protein_features":false,"name":"PRE3","ortholog_annotations":[{"gene_uniquename":"YJL001W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03151","reference_uniquename":"PMID:29761456"}],"product":"Beta 1 subunit of the 20S proteasome; responsible for cleavage after acidic residues in peptides","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003538","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL001W"}


id: YJL002C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01006":null,"YJL002C":null},"has_protein_features":false,"name":"OST1","ortholog_annotations":[{"gene_uniquename":"YJL002C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01006","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003539","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL002C"}


id: YJL003W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03296":null,"YJL003W":null},"has_protein_features":false,"name":"COX16","ortholog_annotations":[{"gene_uniquename":"YJL003W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03296","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial inner membrane protein; required for assembly of cytochrome c oxidase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003540","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL003W"}


id: YJL004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SYS1","product":"Integral membrane protein of the Golgi; required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation","secondary_identifier":"SGD:S000003541","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL004C"}


id: YJL005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01254":null,"YJL005W":null},"has_protein_features":false,"name":"CYR1","ortholog_annotations":[{"gene_uniquename":"YJL005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01254","reference_uniquename":"PMID:29761456"}],"product":"Adenylate cyclase; required for cAMP production and cAMP-dependent protein kinase signaling; scaffold protein for Ras2-Ira interaction; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003542","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL005W"}


id: YJL006C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02057":null,"YJL006C":null},"has_protein_features":false,"name":"CTK2","ortholog_annotations":[{"gene_uniquename":"YJL006C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02057","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of C-terminal domain kinase I (CTDK-I); which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003543","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL006C"}


id: YJL007C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains","secondary_identifier":"SGD:S000003544","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL007C"}


id: YJL008C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00447":null,"YJL008C":null},"has_protein_features":false,"name":"CCT8","ortholog_annotations":[{"gene_uniquename":"YJL008C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00447","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003545","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL008C"}


id: YJL009W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex","secondary_identifier":"SGD:S000003546","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL009W"}


id: YJL010C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02250":null,"YJL010C":null},"has_protein_features":false,"name":"NOP9","ortholog_annotations":[{"gene_uniquename":"YJL010C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02250","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of U3-containing 90S preribosome; involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003547","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL010C"}


id: YJL011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03035":null,"YJL011C":null},"has_protein_features":false,"name":"RPC17","ortholog_annotations":[{"gene_uniquename":"YJL011C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03035","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003548","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL011C"}


id: YJL012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01080":null,"YJL012C":null},"has_protein_features":false,"name":"VTC4","ortholog_annotations":[{"gene_uniquename":"YJL012C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01080","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar membrane polyphosphate polymerase; subunit of vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003549","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL012C"}


id: YJL012C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YJL012C-A was originally annotated as an independent ORF but due to a sequence change was merged with an adjacent ORF into a single reading frame, designated YJL012C/VTC4","secondary_identifier":"SGD:S000007609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL012C-A"}


id: YJL013C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04699":null,"YJL013C":null},"has_protein_features":false,"name":"MAD3","ortholog_annotations":[{"gene_uniquename":"YJL013C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04699","reference_uniquename":"PMID:29761456"}],"product":"Subunit of spindle-assembly checkpoint complex; involved in delaying anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover; MAD3 has a paralog, BUB1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003550","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL013C"}


id: YJL014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03570":null,"YJL014W":null},"has_protein_features":false,"name":"CCT3","ortholog_annotations":[{"gene_uniquename":"YJL014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03570","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; capable of binding Q/N rich proteins and mediating their folding","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003551","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL014W"}


id: YJL015C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W","secondary_identifier":"SGD:S000003552","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL015C"}


id: YJL016W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TPH3","product":"Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; contains two adjacent PH-like domains; conserved in closely related Saccharomyces species","secondary_identifier":"SGD:S000003553","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL016W"}


id: YJL017W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YJL017W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YJL016W","secondary_identifier":"SGD:S000003554","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL017W"}


id: YJL018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YJL018W was originally annotated as an independent ORF, but as a result of a sequence change, it was merged with an adjacent ORF into a single reading frame, designated YJL019W","secondary_identifier":"SGD:S000003555","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL018W"}


id: YJL019W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05196":null,"YJL019W":null},"has_protein_features":false,"name":"MPS3","ortholog_annotations":[{"gene_uniquename":"YJL019W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05196","reference_uniquename":"PMID:29761456"}],"product":"Nuclear envelope protein; required for SPB insertion, SPB duplication, Kar5p localization near the SPB and nuclear fusion; interacts with Mps2p to tether half-bridge to core SPB; N-terminal acetylation by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; member of the SUN protein family (Sad1-UNC-84 homology)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003556","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL019W"}


id: YJL020C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02202":null,"YJL020C":null},"has_protein_features":false,"name":"BBC1","ortholog_annotations":[{"gene_uniquename":"YJL020C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02202","reference_uniquename":"PMID:29761456"}],"product":"Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003557","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL020C"}


id: YJL020W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL020C/BBC1","secondary_identifier":"SGD:S000028659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL020W-A"}


id: YJL021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Merged open reading frame; does not encode a discrete protein; YJL021C was originally annotated as an independent ORF but due to a sequence change was merged with an adjacent ORF into a single reading frame, designated YJL020C/BBC1","secondary_identifier":"SGD:S000003558","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL021C"}


id: YJL022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130","secondary_identifier":"SGD:S000003559","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL022W"}


id: YJL023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PET130","product":"Protein of unknown function; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; localizes to the matrix side of the inner mitochondrial membrane","secondary_identifier":"SGD:S000003560","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL023C"}


id: YJL024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03726":null,"YJL024C":null},"has_protein_features":false,"name":"APS3","ortholog_annotations":[{"gene_uniquename":"YJL024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03726","reference_uniquename":"PMID:29761456"}],"product":"Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003561","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL024C"}


id: YJL025W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02813":null,"YJL025W":null},"has_protein_features":false,"name":"RRN7","ortholog_annotations":[{"gene_uniquename":"YJL025W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02813","reference_uniquename":"PMID:29761456"}],"product":"Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003562","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL025W"}


id: YJL026C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL026W/RNR2","secondary_identifier":"SGD:S000028660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL026C-A"}


id: YJL026W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00885":null,"YJL026W":null},"has_protein_features":false,"name":"RNR2","ortholog_annotations":[{"gene_uniquename":"YJL026W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00885","reference_uniquename":"PMID:29761456"}],"product":"Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; RNR2 has a paralog, RNR4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003563","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL026W"}


id: YJL027C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000003564","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL027C"}


id: YJL028W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments","secondary_identifier":"SGD:S000003565","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL028W"}


id: YJL029C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04902":null,"YJL029C":null},"has_protein_features":false,"name":"VPS53","ortholog_annotations":[{"gene_uniquename":"YJL029C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04902","reference_uniquename":"PMID:29761456"}],"product":"Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; required for vacuolar protein sorting; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p; human ortholog is implicated in progressive cerebello-cerebral atrophy type 2 (PCCA2)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003566","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL029C"}


id: YJL030W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01330":null,"YJL030W":null},"has_protein_features":false,"name":"MAD2","ortholog_annotations":[{"gene_uniquename":"YJL030W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01330","reference_uniquename":"PMID:29761456"}],"product":"Component of the spindle-assembly checkpoint complex; delays onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003567","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL030W"}


id: YJL031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03810":null,"YJL031C":null},"has_protein_features":false,"name":"BET4","ortholog_annotations":[{"gene_uniquename":"YJL031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03810","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003568","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL031C"}


id: YJL032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase","secondary_identifier":"SGD:S000003569","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL032W"}


id: YJL033W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02287":null,"YJL033W":null},"has_protein_features":false,"name":"HCA4","ortholog_annotations":[{"gene_uniquename":"YJL033W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02287","reference_uniquename":"PMID:29761456"}],"product":"DEAD box RNA helicase; component of the SSU; interacts with Bfr2p and Enp2p; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003570","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL033W"}


id: YJL034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00790":null,"YJL034W":null},"has_protein_features":false,"name":"KAR2","ortholog_annotations":[{"gene_uniquename":"YJL034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00790","reference_uniquename":"PMID:29761456"}],"product":"ATPase involved in protein import into the ER; also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003571","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL034W"}


id: YJL035C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04189":null,"YJL035C":null},"has_protein_features":false,"name":"TAD2","ortholog_annotations":[{"gene_uniquename":"YJL035C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04189","reference_uniquename":"PMID:29761456"}],"product":"Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003572","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL035C"}


id: YJL036W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01135":null,"SJAG_01382":null,"YJL036W":null},"has_protein_features":false,"name":"SNX4","ortholog_annotations":[{"gene_uniquename":"YJL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01135","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL036W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01382","reference_uniquename":"PMID:29761456"}],"product":"Sorting nexin; involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003573","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL036W"}


id: YJL037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC18","product":"Protein involved in outer spore wall assembly; possible role in assembly of the dityrosine layer; similar to adjacent ORF, LOH1; irc18 loh1 double mutant exhibits reduced dityrosine fluorescence relative to single mutants; SWAT-GFP fusion protein localizes to the ER and vacuole, while mCherry fusion localizes to the vacuole; expression induced in respiratory-deficient cells and carbon-limited chemostat culture; null mutant displays increased levels of spontaneous Rad52p foci","secondary_identifier":"SGD:S000003574","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL037W"}


id: YJL038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LOH1","product":"Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to adjacent ORF, IRC18/YJL037W, and the irc18 loh1 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants; SWAT-GFP and mCherry fusion proteins localize to the cytosol; proposed role in maintenance of genome integrity","secondary_identifier":"SGD:S000003575","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL038C"}


id: YJL039C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03182":null,"YJL039C":null},"has_protein_features":false,"name":"NUP192","ortholog_annotations":[{"gene_uniquename":"YJL039C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03182","reference_uniquename":"PMID:29761456"}],"product":"Essential subunit of inner ring of nuclear pore complex (NPC); plays a role in modulating transport through the NPC; homologous to human NUP205","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003576","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL039C"}


id: YJL041W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02274":null,"YJL041W":null},"has_protein_features":false,"name":"NSP1","ortholog_annotations":[{"gene_uniquename":"YJL041W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02274","reference_uniquename":"PMID:29761456"}],"product":"FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003577","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL041W"}


id: YJL042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MHP1","product":"Microtubule-associated protein involved in microtubule organization; involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins","secondary_identifier":"SGD:S000003578","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL042W"}


id: YJL043W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YJL043W is a non-essential gene","secondary_identifier":"SGD:S000003579","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL043W"}


id: YJL044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GYP6","product":"GTPase-activating protein (GAP) for yeast Rab family member Ypt6p; involved in vesicle mediated protein transport","secondary_identifier":"SGD:S000003580","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL044C"}


id: YJL045W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01671":null,"YJL045W":null},"has_protein_features":false,"name":"SDH9","ortholog_annotations":[{"gene_uniquename":"YJL045W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01671","reference_uniquename":"PMID:29761456"}],"product":"Minor succinate dehydrogenase isozyme; participates in oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner; YJL045W has a paralog, SDH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003581","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL045W"}


id: YJL046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01164":null,"YJL046W":null},"has_protein_features":false,"name":"AIM22","ortholog_annotations":[{"gene_uniquename":"YJL046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01164","reference_uniquename":"PMID:29761456"}],"product":"Lipoate-protein ligase; octanoyl-CoA: protein transferase required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003582","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL046W"}


id: YJL047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RTT101","product":"Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; role in anaphase progression; Rtt101p-Mms22p ligase associates with replisome complex during S phase via Ctf4p; required for recovery after DSB repair; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p","secondary_identifier":"SGD:S000003583","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL047C"}


id: YJL047C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function","secondary_identifier":"SGD:S000028804","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL047C-A"}


id: YJL048C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"UBX6","product":"UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003584","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL048C"}


id: YJL049W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05207":null,"YJL049W":null},"has_protein_features":false,"name":"CHM7","ortholog_annotations":[{"gene_uniquename":"YJL049W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05207","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidic acid (PA)-binding nuclear envelope (NE)-specific ESCRT; homolog of human CHMP7, localizes to the endoplasmic reticulum presumably as part of ESCRT-III like complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003585","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL049W"}


id: YJL050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_16455":null,"YJL050W":null},"has_protein_features":false,"name":"MTR4","ortholog_annotations":[{"gene_uniquename":"YJL050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16455","reference_uniquename":"PMID:29761456"}],"product":"RNA duplex-sensing translocase; ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003586","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL050W"}


id: YJL051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC8","product":"Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc","secondary_identifier":"SGD:S000003587","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL051W"}


id: YJL052C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified based on comparison to related yeast species; mCherry fusion protein localizes to the vacuole","secondary_identifier":"SGD:S000007610","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL052C-A"}


id: YJL052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00027":null,"SJAG_02135":null,"SJAG_02945":null,"SJAG_03828":null,"SJAG_03903":null,"SJAG_06621":null,"SJAG_06622":null,"YJL052W":null},"has_protein_features":false,"name":"TDH1","ortholog_annotations":[{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00027","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02135","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02945","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03828","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03903","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06621","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06622","reference_uniquename":"PMID:29761456"}],"product":"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bacteria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003588","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL052W"}


id: YJL053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00632":null,"YJL053W":null},"has_protein_features":false,"name":"PEP8","ortholog_annotations":[{"gene_uniquename":"YJL053W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00632","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003589","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL053W"}


id: YJL054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00404":null,"YJL054W":null},"has_protein_features":false,"name":"TIM54","ortholog_annotations":[{"gene_uniquename":"YJL054W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00404","reference_uniquename":"PMID:29761456"}],"product":"Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003590","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL054W"}


id: YJL055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LOG1","product":"Putative protein of unknown function; functions together with HAM1 to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA, without affecting uptake or incorporation of uracil into RNA; proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA","secondary_identifier":"SGD:S000003591","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL055W"}


id: YJL056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ZAP1","product":"Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains","secondary_identifier":"SGD:S000003592","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL056C"}


id: YJL057C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IKS1","product":"Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p","secondary_identifier":"SGD:S000003593","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL057C"}


id: YJL058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01020":null,"SJAG_04987":null,"YJL058C":null},"has_protein_features":false,"name":"BIT61","ortholog_annotations":[{"gene_uniquename":"YJL058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01020","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04987","reference_uniquename":"PMID:29761456"}],"product":"Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; PM retention is dependent on Avo3p; BIT61 has a paralog, BIT2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003594","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL058C"}


id: YJL059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02716":null,"YJL059W":null},"has_protein_features":false,"name":"YHC3","ortholog_annotations":[{"gene_uniquename":"YJL059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02716","reference_uniquename":"PMID:29761456"}],"product":"Protein required for the ATP-dependent transport of arginine; vacuolar membrane protein; involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; human homolog CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) can complement yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003595","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL059W"}


id: YJL060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04988":null,"YJL060W":null},"has_protein_features":false,"name":"BNA3","ortholog_annotations":[{"gene_uniquename":"YJL060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04988","reference_uniquename":"PMID:29761456"}],"product":"Kynurenine aminotransferase; catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003596","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL060W"}


id: YJL061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01065":null,"YJL061W":null},"has_protein_features":false,"name":"NUP82","ortholog_annotations":[{"gene_uniquename":"YJL061W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01065","reference_uniquename":"PMID:29761456"}],"product":"Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p); relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003597","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL061W"}


id: YJL062W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02523":null,"YJL062W":null},"has_protein_features":false,"name":"LAS21","ortholog_annotations":[{"gene_uniquename":"YJL062W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02523","reference_uniquename":"PMID:29761456"}],"product":"Mannose-ethanolamine phosphotransferase; involved in biosynthesis of the glycosylphosphatidylinositol (GPI) core structure, catalyzing the addition of a side chain ethanolamine phosphate to the alpha1,6-linked second mannose residue of the GPI lipid precursor;  integral component of endoplasmic reticulum membrane; mutations affect cell wall integrity; homolog of human PIGG","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003598","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL062W"}


id: YJL062W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04348":null,"YJL062W-A":null},"has_protein_features":false,"name":"COA3","ortholog_annotations":[{"gene_uniquename":"YJL062W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04348","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein required for cytochrome c oxidase assembly; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; located in the mitochondrial inner membrane","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000007611","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL062W-A"}


id: YJL063C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01591":null,"YJL063C":null},"has_protein_features":false,"name":"MRPL8","ortholog_annotations":[{"gene_uniquename":"YJL063C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01591","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003599","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL063C"}


id: YJL064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1","secondary_identifier":"SGD:S000003600","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL064W"}


id: YJL065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DLS1","product":"Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003601","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL065C"}


id: YJL066C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MPM1","product":"Mitochondrial intermembrane space protein of unknown function","secondary_identifier":"SGD:S000003602","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL066C"}


id: YJL067W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003603","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL067W"}


id: YJL068C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Esterase that can function as an S-formylglutathione hydrolase; non-essential intracellular esterase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D","secondary_identifier":"SGD:S000003604","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL068C"}


id: YJL069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00538":null,"YJL069C":null},"has_protein_features":false,"name":"UTP18","ortholog_annotations":[{"gene_uniquename":"YJL069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00538","reference_uniquename":"PMID:29761456"}],"product":"Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; contains WD40 repeats","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003605","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL069C"}


id: YJL070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003606","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL070C"}


id: YJL071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00695":null,"YJL071W":null},"has_protein_features":false,"name":"ARG2","ortholog_annotations":[{"gene_uniquename":"YJL071W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00695","reference_uniquename":"PMID:29761456"}],"product":"Acetylglutamate synthase (glutamate N-acetyltransferase); mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003607","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL071W"}


id: YJL072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00696":null,"YJL072C":null},"has_protein_features":false,"name":"PSF2","ortholog_annotations":[{"gene_uniquename":"YJL072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00696","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003608","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL072C"}


id: YJL073W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"JEM1","product":"DnaJ-like chaperone required for nuclear membrane fusion during mating; localizes to the ER membrane; exhibits genetic interactions with KAR2","secondary_identifier":"SGD:S000003609","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL073W"}


id: YJL074C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05019":null,"YJL074C":null},"has_protein_features":false,"name":"SMC3","ortholog_annotations":[{"gene_uniquename":"YJL074C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05019","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the multiprotein cohesin complex; required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003610","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL074C"}


id: YJL075C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"APQ13","product":"Putative protein of unknown function; not conserved in closely related Saccharomyces species; 85% of ORF overlaps verified gene NET1, but does not share all phenotypes; null mutant is slow-growing, sensitive to heat, sorbate, and other various chemicals","secondary_identifier":"SGD:S000003611","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL075C"}


id: YJL076W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00883":null,"YJL076W":null},"has_protein_features":false,"name":"NET1","ortholog_annotations":[{"gene_uniquename":"YJL076W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00883","reference_uniquename":"PMID:29761456"}],"product":"Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003612","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL076W"}


id: YJL077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ICS3","product":"Protein with a role in copper homeostasis; possible role in vacuolar sorting and processing of secretory proteins; null mutants are hypersensitive to sortin2","secondary_identifier":"SGD:S000003613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL077C"}


id: YJL077W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; mRNA identified as translated by ribosome profiling data; completely overlaps the verified gene YJL077C/ICS3","secondary_identifier":"SGD:S000028661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL077W-A"}


id: YJL077W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching","secondary_identifier":"SGD:S000028662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL077W-B"}


id: YJL078C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRY3","product":"GPI-anchored cell wall protein involved in export of sterols; redundant role with PRY1 and PRY2 in the export of free fatty acids; role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins)","secondary_identifier":"SGD:S000003614","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL078C"}


id: YJL079C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PRY1","product":"Lipid binding protein; binds to both free fatty acids with preference for saturated long-chain fatty acids and to sterols; contains two independent lipid-binding sites; involved in the export of free fatty acids and acetylated sterols; export functions are redundant with PRY2, and PRY3; important for survival of cells that accumulate free fatty acids; involved in detoxification  of hydrophobic compounds; secreted glycoprotein and member of the CAP/SCP protein superfamily","secondary_identifier":"SGD:S000003615","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL079C"}


id: YJL080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03696":null,"YJL080C":null},"has_protein_features":false,"name":"SCP160","ortholog_annotations":[{"gene_uniquename":"YJL080C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03696","reference_uniquename":"PMID:29761456"}],"product":"Essential RNA-binding G protein effector of mating response pathway; ligand-activated RNA-binding protein that delivers RNAs involved in polarization and perpetualizing mating signal to shmoo tip during pheromone signaling; Scp160p-mediated RNA trafficking essential for chemotropism and successful mating; mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003616","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL080C"}


id: YJL081C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01016":null,"SJAG_03058":null,"SJAG_03579":null,"YJL081C":null},"has_protein_features":false,"name":"ARP4","ortholog_annotations":[{"gene_uniquename":"YJL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01016","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03058","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJL081C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03579","reference_uniquename":"PMID:29761456"}],"product":"Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003617","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL081C"}


id: YJL082W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00219":null,"SJAG_00270":null,"YJL082W":null},"has_protein_features":false,"name":"IML2","ortholog_annotations":[{"gene_uniquename":"YJL082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00219","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL082W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00270","reference_uniquename":"PMID:29761456"}],"product":"Protein required for clearance of inclusion bodies; localizes to the inclusion bodies formed under protein misfolding stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003618","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL082W"}


id: YJL083W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00724":null,"YJL083W":null},"has_protein_features":false,"name":"TAX4","ortholog_annotations":[{"gene_uniquename":"YJL083W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00724","reference_uniquename":"PMID:29761456"}],"product":"EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003619","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL083W"}


id: YJL084C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00032":null,"SJAG_03643":null,"YJL084C":null},"has_protein_features":false,"name":"ALY2","ortholog_annotations":[{"gene_uniquename":"YJL084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00032","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL084C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03643","reference_uniquename":"PMID:29761456"}],"product":"Alpha arrestin, Ub-ligase adaptor for Rsp5p; controls nutrient limitation-mediated endosomal recycling of the Gap1p amino acid permease; PY motif-containing adaptor involved in substrate-induced, Rsp5p-mediated ubiquitination and endocytosis of select plasma membrane localized amino acid transporters, such as Dip5p and Put4p; regulates intracellular pH; phosphorylated by Npr1p and by the Pcl7p-Pho85p cyclin-CDK complex; interacts with AP-1 subunit Apl4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003620","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL084C"}


id: YJL085W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04960":null,"YJL085W":null},"has_protein_features":false,"name":"EXO70","ortholog_annotations":[{"gene_uniquename":"YJL085W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04960","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003621","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL085W"}


id: YJL086C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1","secondary_identifier":"SGD:S000003622","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL086C"}


id: YJL087C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00956":null,"YJL087C":null},"has_protein_features":false,"name":"TRL1","ortholog_annotations":[{"gene_uniquename":"YJL087C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00956","reference_uniquename":"PMID:29761456"}],"product":"tRNA ligase; required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; involved in turnover of tRNA introns; localized at the inner nuclear envelope and cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003623","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL087C"}


id: YJL088W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00635":null,"YJL088W":null},"has_protein_features":false,"name":"ARG3","ortholog_annotations":[{"gene_uniquename":"YJL088W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00635","reference_uniquename":"PMID:29761456"}],"product":"Ornithine carbamoyltransferase; also known as carbamoylphosphate:L-ornithine carbamoyltransferase; catalyzes the biosynthesis of the arginine precursor citrulline","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003624","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL088W"}


id: YJL089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SIP4","product":"C6 zinc cluster transcriptional activator; binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus","secondary_identifier":"SGD:S000003625","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL089W"}


id: YJL090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02098":null,"YJL090C":null},"has_protein_features":false,"name":"DPB11","ortholog_annotations":[{"gene_uniquename":"YJL090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02098","reference_uniquename":"PMID:29761456"}],"product":"DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; along with Rfa1p, binds to ultrafine anaphase bridges in mitotic cells and prevents accumulation of chromatin bridges by stimulating the Mec1p kinase and suppressing homologous recombination; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003626","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL090C"}


id: YJL091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00068":null,"YJL091C":null},"has_protein_features":false,"name":"GWT1","ortholog_annotations":[{"gene_uniquename":"YJL091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00068","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in the inositol acylation of GlcN-PI; the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) forms glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003627","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL091C"}


id: YJL092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01221":null,"YJL092W":null},"has_protein_features":false,"name":"SRS2","ortholog_annotations":[{"gene_uniquename":"YJL092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01221","reference_uniquename":"PMID:29761456"}],"product":"DNA helicase and DNA-dependent ATPase; role in DNA repair and checkpoint recovery, in the proper timing of commitment to meiotic recombination and the Meiosis I to II transition; blocks trinucleotide repeat expansion; affects genome stability; disassembles Rad51p nucleoprotein filaments during meiotic recombination; stimulates Mus81p-Mms4p endonuclease activity independent of catalytic activity; ATPase and ssDNA translocating motor activities inhibited by Dmc1p; functional homolog of human RTEL1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003628","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL092W"}


id: YJL093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TOK1","product":"Outward-rectifier potassium channel of the plasma membrane; has two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin","secondary_identifier":"SGD:S000003629","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL093C"}


id: YJL094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"KHA1","product":"Putative K+/H+ antiporter; involved in intracellular cation homeostasis; promotes copper binding to Fet3p multicopper oxidase; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000003630","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL094C"}


id: YJL095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03753":null,"YJL095W":null},"has_protein_features":false,"name":"BCK1","ortholog_annotations":[{"gene_uniquename":"YJL095W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03753","reference_uniquename":"PMID:29761456"}],"product":"MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003631","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL095W"}


id: YJL096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01630":null,"YJL096W":null},"has_protein_features":false,"name":"MRPL49","ortholog_annotations":[{"gene_uniquename":"YJL096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01630","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the large subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003632","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL096W"}


id: YJL097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01300":null,"YJL097W":null},"has_protein_features":false,"name":"PHS1","ortholog_annotations":[{"gene_uniquename":"YJL097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01300","reference_uniquename":"PMID:29761456"}],"product":"Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane; involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003633","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL097W"}


id: YJL098W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04638":null,"YJL098W":null},"has_protein_features":false,"name":"SAP185","ortholog_annotations":[{"gene_uniquename":"YJL098W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04638","reference_uniquename":"PMID:29761456"}],"product":"Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003634","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL098W"}


id: YJL099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00916":null,"YJL099W":null},"has_protein_features":false,"name":"CHS6","ortholog_annotations":[{"gene_uniquename":"YJL099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00916","reference_uniquename":"PMID:29761456"}],"product":"Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; primary component of the Chs5/6 complex that binds directly to membranes; CHS6 has a paralog, BCH2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003635","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL099W"}


id: YJL100W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01571":null,"YJL100W":null},"has_protein_features":false,"name":"LSB6","ortholog_annotations":[{"gene_uniquename":"YJL100W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01571","reference_uniquename":"PMID:29761456"}],"product":"Type II phosphatidylinositol 4-kinase; binds Las17p, a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003636","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL100W"}


id: YJL101C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00988":null,"YJL101C":null},"has_protein_features":false,"name":"GSH1","ortholog_annotations":[{"gene_uniquename":"YJL101C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00988","reference_uniquename":"PMID:29761456"}],"product":"Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003637","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL101C"}


id: YJL102W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04862":null,"YJL102W":null},"has_protein_features":false,"name":"MEF2","ortholog_annotations":[{"gene_uniquename":"YJL102W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04862","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial elongation factor involved in translational elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003638","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL102W"}


id: YJL103C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GSM1","product":"Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis","secondary_identifier":"SGD:S000003639","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL103C"}


id: YJL104W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00373":null,"YJL104W":null},"has_protein_features":false,"name":"PAM16","ortholog_annotations":[{"gene_uniquename":"YJL104W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00373","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the import motor (PAM complex); the PAM complex is a  component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003640","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL104W"}


id: YJL105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04396":null,"YJL105W":null},"has_protein_features":false,"name":"SET4","ortholog_annotations":[{"gene_uniquename":"YJL105W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04396","reference_uniquename":"PMID:29761456"}],"product":"Chromatin-associated protein involved in control of stress response; regulates response to oxidative stress; involved in control of gene repression in subtelomeric chromatin; contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003641","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL105W"}


id: YJL106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02712":null,"SJAG_03557":null,"YJL106W":null},"has_protein_features":false,"name":"IME2","ortholog_annotations":[{"gene_uniquename":"YJL106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02712","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03557","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase involved in activation of meiosis; associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p; human CDK2 can complement ime2 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003642","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL106W"}


id: YJL107C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01770":null,"SJAG_04957":null,"YJL107C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJL107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01770","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL107C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04957","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003643","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL107C"}


id: YJL108C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01770":null,"SJAG_04957":null,"YJL108C":null},"has_protein_features":false,"name":"PRM10","ortholog_annotations":[{"gene_uniquename":"YJL108C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01770","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJL108C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04957","reference_uniquename":"PMID:26896847"}],"product":"Pheromone-regulated protein; proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation","references_by_uniquename":{"PMID:26896847":null},"secondary_identifier":"SGD:S000003644","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL108C"}


id: YJL109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05187":null,"YJL109C":null},"has_protein_features":false,"name":"UTP10","ortholog_annotations":[{"gene_uniquename":"YJL109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05187","reference_uniquename":"PMID:29761456"}],"product":"Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003645","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL109C"}


id: YJL110C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00792":null,"YJL110C":null},"has_protein_features":false,"name":"GZF3","ortholog_annotations":[{"gene_uniquename":"YJL110C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00792","reference_uniquename":"PMID:29761456"}],"product":"GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003646","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL110C"}


id: YJL111W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02926":null,"YJL111W":null},"has_protein_features":false,"name":"CCT7","ortholog_annotations":[{"gene_uniquename":"YJL111W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02926","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003647","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL111W"}


id: YJL112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04732":null,"YJL112W":null},"has_protein_features":false,"name":"MDV1","ortholog_annotations":[{"gene_uniquename":"YJL112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04732","reference_uniquename":"PMID:29761456"}],"product":"Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the self-assembled oligomeric form of the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003648","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL112W"}


id: YJL115W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03366":null,"YJL115W":null},"has_protein_features":false,"name":"ASF1","ortholog_annotations":[{"gene_uniquename":"YJL115W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03366","reference_uniquename":"PMID:29761456"}],"product":"Nucleosome assembly factor; involved in chromatin assembly, disassembly; required for recovery after DSB repair; role in H3K56 acetylation required for expression homeostasis, buffering mRNA synthesis rate against gene dosage changes in S phase; anti-silencing protein, derepresses silent loci when overexpressed; role in regulating Ty1 transposition; relocalizes to cytosol under hypoxia; growth defect of asf1 null is functionally complemented by either human ASF1A or ASF1B","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003651","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL115W"}


id: YJL116C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02649":null,"SJAG_03295":null,"YJL116C":null},"has_protein_features":false,"name":"NCA3","ortholog_annotations":[{"gene_uniquename":"YJL116C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02649","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL116C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03295","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the vacuole; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003652","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL116C"}


id: YJL117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01899":null,"YJL117W":null},"has_protein_features":false,"name":"PHO86","ortholog_annotations":[{"gene_uniquename":"YJL117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01899","reference_uniquename":"PMID:29761456"}],"product":"Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003653","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL117W"}


id: YJL118W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL118W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein","secondary_identifier":"SGD:S000003654","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL118W"}


id: YJL119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003655","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL119C"}


id: YJL120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO","secondary_identifier":"SGD:S000003656","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL120W"}


id: YJL121C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00501":null,"YJL121C":null},"has_protein_features":false,"name":"RPE1","ortholog_annotations":[{"gene_uniquename":"YJL121C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00501","reference_uniquename":"PMID:29761456"}],"product":"D-ribulose-5-phosphate 3-epimerase; catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003657","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL121C"}


id: YJL122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00932":null,"YJL122W":null},"has_protein_features":false,"name":"ALB1","ortholog_annotations":[{"gene_uniquename":"YJL122W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00932","reference_uniquename":"PMID:29761456"}],"product":"Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003658","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL122W"}


id: YJL123C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01085":null,"YJL123C":null},"has_protein_features":false,"name":"MTC1","ortholog_annotations":[{"gene_uniquename":"YJL123C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01085","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003659","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL123C"}


id: YJL124C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04880":null,"YJL124C":null},"has_protein_features":false,"name":"LSM1","ortholog_annotations":[{"gene_uniquename":"YJL124C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04880","reference_uniquename":"PMID:29761456"}],"product":"Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; also enters the nucleus and positively regulates transcription initiation; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; binds to mRNAs under glucose starvation, most often in the 3' UTR; forms cytoplasmic foci upon DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003660","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL124C"}


id: YJL125C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02386":null,"YJL125C":null},"has_protein_features":false,"name":"GCD14","ortholog_annotations":[{"gene_uniquename":"YJL125C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02386","reference_uniquename":"PMID:29761456"}],"product":"Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003661","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL125C"}


id: YJL126W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04939":null,"YJL126W":null},"has_protein_features":false,"name":"NIT2","ortholog_annotations":[{"gene_uniquename":"YJL126W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04939","reference_uniquename":"PMID:29761456"}],"product":"Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003662","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL126W"}


id: YJL127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SPT10","product":"Histone H3 acetylase with a role in transcriptional regulation; sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near TATA box; involved in S phase-specific acetylation of H3K56 at histone promoters, which is required for recruitment of SWI/SNF nucleosome remodeling complex and subsequent transcription","secondary_identifier":"SGD:S000003663","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL127C"}


id: YJL127C-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05268":null,"YJL127C-B":null},"has_protein_features":false,"name":"MCO6","ortholog_annotations":[{"gene_uniquename":"YJL127C-B","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05268","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial outer membrane protein protein; co-assembles with Mdm10p into the mitochondrial sorting and assembly machinery (SAM) complex and cooperates with Mdm10p in the assembly of the translocase of the outer membrane (TOM) complex; identified based on homology to the filamentous fungus, <i>Ashbya gossypii</i>; SWAT-GFP and seamless-GFP fusion proteins localize to the mitochondria","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028522","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL127C-B"}


id: YJL127W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007612","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL127W-A"}


id: YJL128C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02342":null,"YJL128C":null},"has_protein_features":false,"name":"PBS2","ortholog_annotations":[{"gene_uniquename":"YJL128C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02342","reference_uniquename":"PMID:29761456"}],"product":"MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003664","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL128C"}


id: YJL129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01353":null,"SJAG_02883":null,"YJL129C":null},"has_protein_features":false,"name":"TRK1","ortholog_annotations":[{"gene_uniquename":"YJL129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01353","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02883","reference_uniquename":"PMID:29761456"}],"product":"Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003665","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL129C"}


id: YJL130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00964":null,"YJL130C":null},"has_protein_features":false,"name":"URA2","ortholog_annotations":[{"gene_uniquename":"YJL130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00964","reference_uniquename":"PMID:29761456"}],"product":"Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003666","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL130C"}


id: YJL131C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04635":null,"YJL131C":null},"has_protein_features":false,"name":"AIM23","ortholog_annotations":[{"gene_uniquename":"YJL131C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04635","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; interacts with mitochondrial ribosomal small subunit; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003667","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL131C"}


id: YJL132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene","secondary_identifier":"SGD:S000003668","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL132W"}


id: YJL133C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DPI8","product":"Putative mitochondrial protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000028805","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL133C-A"}


id: YJL133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02473":null,"SJAG_04737":null,"YJL133W":null},"has_protein_features":false,"name":"MRS3","ortholog_annotations":[{"gene_uniquename":"YJL133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02473","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04737","reference_uniquename":"PMID:29761456"}],"product":"Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003669","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL133W"}


id: YJL134W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04986":null,"YJL134W":null},"has_protein_features":false,"name":"LCB3","ortholog_annotations":[{"gene_uniquename":"YJL134W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04986","reference_uniquename":"PMID:29761456"}],"product":"Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003670","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL134W"}


id: YJL135W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3","secondary_identifier":"SGD:S000003671","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL135W"}


id: YJL136C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04174":null,"YJL136C":null},"has_protein_features":false,"name":"RPS21B","ortholog_annotations":[{"gene_uniquename":"YJL136C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04174","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003672","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL136C"}


id: YJL136W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; identified by SAGE","secondary_identifier":"SGD:S000028806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL136W-A"}


id: YJL137C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GLG2","product":"Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003673","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL137C"}


id: YJL138C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04772":null,"YJL138C":null},"has_protein_features":false,"name":"TIF2","ortholog_annotations":[{"gene_uniquename":"YJL138C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04772","reference_uniquename":"PMID:29761456"}],"product":"Translation initiation factor eIF4A; DEAD-box RNA helicase that couples ATPase activity to mRNA binding and unwinding; ATP hydrolysis accelerates the recruitment of mRNA during 48S preinitiation complex (PIC) assembly; ATPase activity stimulated by either eIF4G1 or by the PIC in an eIF3g and eIFGi subunit-dependent manner, independent of eIF4E and eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E and eIF4G; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003674","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL138C"}


id: YJL139C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00598":null,"SJAG_01021":null,"SJAG_01264":null,"YJL139C":null},"has_protein_features":false,"name":"YUR1","ortholog_annotations":[{"gene_uniquename":"YJL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00598","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01021","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL139C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01264","reference_uniquename":"PMID:29761456"}],"product":"Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003675","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL139C"}


id: YJL140W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00458":null,"YJL140W":null},"has_protein_features":false,"name":"RPB4","ortholog_annotations":[{"gene_uniquename":"YJL140W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00458","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003676","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL140W"}


id: YJL141C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02392":null,"SJAG_03887":null,"SJAG_04980":null,"YJL141C":null},"has_protein_features":false,"name":"YAK1","ortholog_annotations":[{"gene_uniquename":"YJL141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02392","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03887","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL141C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04980","reference_uniquename":"PMID:29761456"}],"product":"Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003677","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL141C"}


id: YJL142C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IRC9","product":"Putative protein of unknown function; partially overlaps verified gene YAK1/YJL141C but does not share all phenotypes; null mutant displays increased levels of spontaneous Rad52p foci, increased sporulation efficiency, and small defect in vacuolar fragmentation","secondary_identifier":"SGD:S000003678","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL142C"}


id: YJL143W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01879":null,"YJL143W":null},"has_protein_features":false,"name":"TIM17","ortholog_annotations":[{"gene_uniquename":"YJL143W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01879","reference_uniquename":"PMID:29761456"}],"product":"Essential core component of the TIM23 protein translocase complex; forms the protein translocation path with Mgr2p, while Tim23p contributes to the architecture of the import channel; may link the import motor to the core translocase of the inner mitochondrial membrane (TIM23 complex)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003679","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL143W"}


id: YJL144W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ROQ1","product":"Ub-ligase substrate-specificity factor; proteolytically-cleaved form acts as a pseudosubstrate, binding and altering the substrate specificity of Ubr1p towards misfolded and native ER membrane and cytosolic proteins, as part of the stress-induced homeostatically regulated protein degradation (SHRED) pathway; hydrophilin essential during desiccation-rehydration; induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress","secondary_identifier":"SGD:S000003680","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL144W"}


id: YJL145W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SFH5","product":"Unusual phosphatidylinositol transfer protein (PITP) that binds heme; similar to Sec14p; founding member of conserved class of fungal hemoproteins; exhibits PI- but not PC-transfer activity; localizes to peripheral endoplasmic reticulum, cytosol, and microsomes; partially relocalizes to plasma membrane upon DNA replication stress","secondary_identifier":"SGD:S000003681","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL145W"}


id: YJL146W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IDS2","product":"Protein involved in modulation of Ime2p activity during meiosis; appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation","secondary_identifier":"SGD:S000003682","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL146W"}


id: YJL147C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SMT1","product":"Translational repressor of the mitochondrial ATP6/8 mRNA; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage","secondary_identifier":"SGD:S000003683","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL147C"}


id: YJL148W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03468":null,"YJL148W":null},"has_protein_features":false,"name":"RPA34","ortholog_annotations":[{"gene_uniquename":"YJL148W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03468","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase I subunit A34.5; essential for nucleolar assembly and for high polymerase loading rate; nucleolar localization depends on Rpa49p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003684","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL148W"}


id: YJL149W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DAS1","product":"Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C","secondary_identifier":"SGD:S000003685","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL149W"}


id: YJL150W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003686","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL150W"}


id: YJL151C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00372":null,"YJL151C":null},"has_protein_features":false,"name":"SNA3","ortholog_annotations":[{"gene_uniquename":"YJL151C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00372","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003687","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL151C"}


id: YJL152W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003688","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL152W"}


id: YJL153C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"INO1","product":"Inositol-3-phosphate synthase; involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element","secondary_identifier":"SGD:S000003689","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL153C"}


id: YJL154C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01039":null,"YJL154C":null},"has_protein_features":false,"name":"VPS35","ortholog_annotations":[{"gene_uniquename":"YJL154C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01039","reference_uniquename":"PMID:29761456"}],"product":"Endosomal subunit of membrane-associated retromer complex; required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p; overexpression of wild-type human VPS35 or Parkinson's-associated vps35-D686N or vps35-P299S variants complements Ni2+ resistance and Cd2+ sensitivity of yeast vps35 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003690","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL154C"}


id: YJL155C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02713":null,"YJL155C":null},"has_protein_features":false,"name":"FBP26","ortholog_annotations":[{"gene_uniquename":"YJL155C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02713","reference_uniquename":"PMID:29761456"}],"product":"Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003691","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL155C"}


id: YJL156C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SSY5","product":"Serine protease of SPS plasma membrane amino acid sensor system; contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p; other members are Ssy1p and Ptr3p","secondary_identifier":"SGD:S000003692","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL156C"}


id: YJL156W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000007613","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL156W-A"}


id: YJL157C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FAR1","product":"CDK inhibitor and nuclear anchor; during the cell cycle Far1p sequesters the GEF Cdc24p in the nucleus; phosphorylation by Cdc28p-Cln results in SCFCdc4 complex-mediated ubiquitin-dependent degradation, releasing Cdc24p for export and activation of GTPase Cdc42p; in response to pheromone, phosphorylation of Far1p by MAPK Fus3p results in association with, and inhibition of Cdc28p-Cln, as well as Msn5p mediated nuclear export of Far1p-Cdc24p, targeting Cdc24p to polarity sites","secondary_identifier":"SGD:S000003693","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL157C"}


id: YJL158C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CIS3","product":"Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family","secondary_identifier":"SGD:S000003694","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL158C"}


id: YJL159W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HSP150","product":"O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003695","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL159W"}


id: YJL160C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PIR5","product":"Putative protein of unknown function; member of the PIR (Proteins with Internal Repeats) family of cell wall proteins; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, and mCherry fusion localizes to the vacuole; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003696","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL160C"}


id: YJL161W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"FMP33","product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000003697","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL161W"}


id: YJL162C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02518":null,"SJAG_03052":null,"YJL162C":null},"has_protein_features":false,"name":"JJJ2","ortholog_annotations":[{"gene_uniquename":"YJL162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02518","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL162C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03052","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; contains a J-domain, which is a region with homology to the E. coli DnaJ protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003698","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL162C"}


id: YJL163C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03447":null,"YJL163C":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJL163C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03447","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003699","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL163C"}


id: YJL164C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04312":null,"YJL164C":null},"has_protein_features":false,"name":"TPK1","ortholog_annotations":[{"gene_uniquename":"YJL164C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04312","reference_uniquename":"PMID:29761456"}],"product":"cAMP-dependent protein kinase catalytic subunit; role in nutrient-stimulated growth via Ras-cAMP signaling; inhibited by regulatory subunit Bcy1p in cAMPs absence; phosphorylates and inhibits Whi3p to promote G1/S phase passage; phosphorylates Nej1p to regulate nonhomologous end joining (NHEJ); impairs mitochondrial import of pre-Tom40p via phosphorylation under non-respiratory conditions; partially redundant with Tpk2p and Tpk3p; human homolog PRKACB regulates NHEJ via NHEJ1 phosphorylation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003700","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL164C"}


id: YJL165C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"HAL5","product":"Snf1p-related nutrient-responsive protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003701","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL165C"}


id: YJL166W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00080":null,"YJL166W":null},"has_protein_features":false,"name":"QCR8","ortholog_annotations":[{"gene_uniquename":"YJL166W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00080","reference_uniquename":"PMID:29761456"}],"product":"Subunit 8 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003702","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL166W"}


id: YJL167W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00580":null,"SJAG_03352":null,"YJL167W":null},"has_protein_features":false,"name":"ERG20","ortholog_annotations":[{"gene_uniquename":"YJL167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00580","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL167W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03352","reference_uniquename":"PMID:29761456"}],"product":"Farnesyl pyrophosphate synthetase; has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003703","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL167W"}


id: YJL168C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02873":null,"YJL168C":null},"has_protein_features":false,"name":"SET2","ortholog_annotations":[{"gene_uniquename":"YJL168C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02873","reference_uniquename":"PMID:29761456"}],"product":"Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for their deacetylation within transcribed genes; involved in transcription coupled-nucleotide excision repair; associates with C-terminal domain (CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003704","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL168C"}


id: YJL169W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2","secondary_identifier":"SGD:S000003705","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL169W"}


id: YJL170C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ASG7","product":"Protein that regulates signaling from G protein beta subunit Ste4p; contributes to relocalization of Ste4p within the cell; specific to a-cells and induced by alpha-factor","secondary_identifier":"SGD:S000003706","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL170C"}


id: YJL171C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00876":null,"YJL171C":null},"has_protein_features":false,"name":"TOH1","ortholog_annotations":[{"gene_uniquename":"YJL171C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00876","reference_uniquename":"PMID:29761456"}],"product":"GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003707","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL171C"}


id: YJL172W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03586":null,"YJL172W":null},"has_protein_features":false,"name":"CPS1","ortholog_annotations":[{"gene_uniquename":"YJL172W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03586","reference_uniquename":"PMID:29761456"}],"product":"Vacuolar carboxypeptidase S; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via AP-3 pathway; expression induced under low-nitrogen conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003708","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL172W"}


id: YJL173C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03722":null,"YJL173C":null},"has_protein_features":false,"name":"RFA3","ortholog_annotations":[{"gene_uniquename":"YJL173C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03722","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003709","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL173C"}


id: YJL174W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04073":null,"YJL174W":null},"has_protein_features":false,"name":"KRE9","ortholog_annotations":[{"gene_uniquename":"YJL174W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04073","reference_uniquename":"PMID:29761456"}],"product":"Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003710","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL174W"}


id: YJL175W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor","secondary_identifier":"SGD:S000003711","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL175W"}


id: YJL176C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02447":null,"SJAG_02589":null,"YJL176C":null},"has_protein_features":false,"name":"SWI3","ortholog_annotations":[{"gene_uniquename":"YJL176C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02447","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL176C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02589","reference_uniquename":"PMID:26896847"}],"product":"Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; contains SANT domain that is required for SWI/SNF assembly; is essential for displacement of histone H2A-H2B dimers during ATP-dependent remodeling; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003712","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL176C"}


id: YJL177W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00940":null,"SJAG_01721":null,"YJL177W":null},"has_protein_features":false,"name":"RPL17B","ortholog_annotations":[{"gene_uniquename":"YJL177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00940","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL177W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01721","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L17B; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003713","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL177W"}


id: YJL178C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG27","product":"Type I membrane protein involved in autophagy and the Cvt pathway; targeted to vacuole via AP-3 pathway","secondary_identifier":"SGD:S000003714","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL178C"}


id: YJL179W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03463":null,"YJL179W":null},"has_protein_features":false,"name":"PFD1","ortholog_annotations":[{"gene_uniquename":"YJL179W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03463","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heterohexameric prefoldin; prefoldin binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003715","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL179W"}


id: YJL180C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01503":null,"YJL180C":null},"has_protein_features":false,"name":"ATP12","ortholog_annotations":[{"gene_uniquename":"YJL180C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01503","reference_uniquename":"PMID:29761456"}],"product":"Assembly factor for F1 sector of mitochondrial F1F0 ATP synthase; conserved protein; required for assembly of alpha and beta subunits into F1 sector of mitochondrial F1F0 ATP synthase; human homolog ATPAF2 can complement yeast atp12 mutant; mutation of human homolog reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003716","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL180C"}


id: YJL181W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RBH1","product":"Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; contains a PH-like domain; RBH1 has a paralog, RBH2, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003717","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL181W"}


id: YJL182C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W","secondary_identifier":"SGD:S000003718","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL182C"}


id: YJL183W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01972":null,"SJAG_02996":null,"SJAG_03555":null,"SJAG_03790":null,"SJAG_03871":null,"SJAG_04095":null,"SJAG_04401":null,"YJL183W":null},"has_protein_features":false,"name":"MNN11","ortholog_annotations":[{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01972","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02996","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03555","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03790","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03871","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04095","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL183W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04401","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a Golgi mannosyltransferase complex; this complex also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003719","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL183W"}


id: YJL184W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06560":null,"YJL184W":null},"has_protein_features":false,"name":"GON7","ortholog_annotations":[{"gene_uniquename":"YJL184W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06560","reference_uniquename":"PMID:29761456"}],"product":"Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; implicated in osmotic stress response; other complex members are Kae1p, Cgi121p, Pcc1p, and Bud32p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003720","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL184W"}


id: YJL185C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ATG36","product":"Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene","secondary_identifier":"SGD:S000003721","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL185C"}


id: YJL186W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MNN5","product":"Alpha-1,2-mannosyltransferase; responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment","secondary_identifier":"SGD:S000003722","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL186W"}


id: YJL187C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03854":null,"SJAG_04280":null,"YJL187C":null},"has_protein_features":false,"name":"SWE1","ortholog_annotations":[{"gene_uniquename":"YJL187C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03854","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL187C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04280","reference_uniquename":"PMID:29761456"}],"product":"Protein kinase that regulates the G2/M transition; negative regulator of the Cdc28p kinase; morphogenesis checkpoint kinase; positive regulator of sphingolipid biosynthesis via Orm2p; phosphorylates a tyrosine residue in the N-terminus of Hsp90 in a cell-cycle associated manner, thus modulating the ability of Hsp90 to chaperone a selected clientele; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003723","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL187C"}


id: YJL188C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BUD19","product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay","secondary_identifier":"SGD:S000003724","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL188C"}


id: YJL189W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03364":null,"YJL189W":null},"has_protein_features":false,"name":"RPL39","ortholog_annotations":[{"gene_uniquename":"YJL189W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03364","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003725","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL189W"}


id: YJL190C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01512":null,"SJAG_03762":null,"YJL190C":null},"has_protein_features":false,"name":"RPS22A","ortholog_annotations":[{"gene_uniquename":"YJL190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01512","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL190C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03762","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003726","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL190C"}


id: YJL191W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01548":null,"SJAG_03424":null,"YJL191W":null},"has_protein_features":false,"name":"RPS14B","ortholog_annotations":[{"gene_uniquename":"YJL191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01548","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL191W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03424","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003727","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL191W"}


id: YJL192C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00277":null,"YJL192C":null},"has_protein_features":false,"name":"SOP4","ortholog_annotations":[{"gene_uniquename":"YJL192C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00277","reference_uniquename":"PMID:29761456"}],"product":"ER-membrane protein; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5 of TOM (Translocase of the Mitochondrial Outer Membrane) complex; suppressor of pma1-7, deletion of SOP4 slows down export of wild-type Pma1p and Pma1-7 from the ER","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003728","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL192C"}


id: YJL193W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00276":null,"YJL193W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJL193W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00276","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003729","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL193W"}


id: YJL194W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02074":null,"YJL194W":null},"has_protein_features":false,"name":"CDC6","ortholog_annotations":[{"gene_uniquename":"YJL194W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02074","reference_uniquename":"PMID:29761456"}],"product":"Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; dual role as a mitotic cyclin-dependent kinase inhibitor, that binds to and inhibits Cdc28p/Clb2p along with Sic1p, contributing to mitotic exit; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress; degraded in response to plasma membrane stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003730","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL194W"}


id: YJL195C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6","secondary_identifier":"SGD:S000003731","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL195C"}


id: YJL196C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01356":null,"SJAG_02885":null,"YJL196C":null},"has_protein_features":false,"name":"ELO1","ortholog_annotations":[{"gene_uniquename":"YJL196C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01356","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL196C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02885","reference_uniquename":"PMID:29761456"}],"product":"Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, ELO2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003732","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL196C"}


id: YJL197C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL197C/UBP12","secondary_identifier":"SGD:S000028839","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL197C-A"}


id: YJL197W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04215":null,"SJAG_04651":null,"YJL197W":null},"has_protein_features":false,"name":"UBP12","ortholog_annotations":[{"gene_uniquename":"YJL197W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04215","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL197W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04651","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003733","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL197W"}


id: YJL198W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01059":null,"YJL198W":null},"has_protein_features":false,"name":"PHO90","ortholog_annotations":[{"gene_uniquename":"YJL198W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01059","reference_uniquename":"PMID:29761456"}],"product":"Low-affinity phosphate transporter; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003734","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL198W"}


id: YJL199C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MBB1","product":"Protein of unknown function; conserved among S. cerevisiae strains, not conserved in closely related Saccharomyces species; protein detected via large-scale protein-protein interaction studies and enrichment-based proteogenomics; YJL199C is not an essential gene","secondary_identifier":"SGD:S000003735","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL199C"}


id: YJL200C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01630":null,"YJL200C":null},"has_protein_features":false,"name":"ACO2","ortholog_annotations":[{"gene_uniquename":"YJL200C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01630","reference_uniquename":"PMID:29761456"}],"product":"Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003736","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL200C"}


id: YJL201W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ECM25","product":"Endocytic site protein required for stress-induced cell elongation; may link the polarization signal with the endocytic machinery to facilitate adaptive morphogenesis under conditions of stress; interacts with the polarity regulator Cdc42p, the SH3 domains of actin patch components and actin filaments; contains a Rho-GAP domain lacking the catalytic arginine finger, PXXP motifs and an xACT (F-actin binding) motif; promoter contains a consensus binding sequence for transcription factor Abf1p","secondary_identifier":"SGD:S000003737","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL201W"}


id: YJL202C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex","secondary_identifier":"SGD:S000003738","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL202C"}


id: YJL203W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04318":null,"YJL203W":null},"has_protein_features":false,"name":"PRP21","ortholog_annotations":[{"gene_uniquename":"YJL203W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04318","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the SF3a splicing factor complex; required for spliceosome assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003739","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL203W"}


id: YJL204C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02753":null,"YJL204C":null},"has_protein_features":false,"name":"RCY1","ortholog_annotations":[{"gene_uniquename":"YJL204C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02753","reference_uniquename":"PMID:29761456"}],"product":"F-box protein involved in recycling endocytosed proteins; involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth; direct interaction with C-terminal cytoplasmic region of Drs2p plays an important role for Drs2p function in endocytic recycling pathway; required for turnover of histone H3 variant Cse4p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003740","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL204C"}


id: YJL205C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07004":null,"YJL205C":null},"has_protein_features":false,"name":"NCE101","ortholog_annotations":[{"gene_uniquename":"YJL205C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07004","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; involved in secretion of proteins that lack classical secretory signal sequences; SWAT-GFP and mCherry fusion proteins localize to the cytosol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003742","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL205C"}


id: YJL206C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment","secondary_identifier":"SGD:S000003741","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL206C"}


id: YJL207C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03504":null,"YJL207C":null},"has_protein_features":false,"name":"LAA1","ortholog_annotations":[{"gene_uniquename":"YJL207C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03504","reference_uniquename":"PMID:29761456"}],"product":"AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003743","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL207C"}


id: YJL208C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01948":null,"YJL208C":null},"has_protein_features":false,"name":"NUC1","ortholog_annotations":[{"gene_uniquename":"YJL208C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01948","reference_uniquename":"PMID:29761456"}],"product":"Major mitochondrial nuclease; has RNAse and DNA endo- and exonucleolytic activities; roles in mitochondrial recombination, apoptosis and maintenance of polyploidy; involved in fragmentation of genomic DNA during PND (programmed nuclear destruction); role in preventing L-A mycovirus pathogenesis; encodes ortholog of mammalian endoG","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003744","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL208C"}


id: YJL209W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CBP1","product":"Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress","secondary_identifier":"SGD:S000003745","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL209W"}


id: YJL210W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PEX2","product":"RING-finger peroxin and E3 ubiquitin ligase; peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import","secondary_identifier":"SGD:S000003746","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL210W"}


id: YJL211C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2","secondary_identifier":"SGD:S000003747","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL211C"}


id: YJL212C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00922":null,"SJAG_01660":null,"YJL212C":null},"has_protein_features":false,"name":"OPT1","ortholog_annotations":[{"gene_uniquename":"YJL212C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00922","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL212C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01660","reference_uniquename":"PMID:29761456"}],"product":"Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003748","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL212C"}


id: YJL213W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p","secondary_identifier":"SGD:S000003749","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL213W"}


id: YJL214W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YJL214W":null},"has_protein_features":false,"name":"HXT8","ortholog_annotations":[{"gene_uniquename":"YJL214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJL214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJL214W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function with similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003750","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL214W"}


id: YJL215C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003751","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL215C"}


id: YJL216C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IMA5","product":"Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; most distant member of the IMA isomaltase family, but with similar catalytic properties as Ima1p and Ima2p; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose; can cleave alpha-1,3 linkage of nigerose and turanose and alpha-1,5 linkage of leucrose and is very sensitive to temperature in vitro","secondary_identifier":"SGD:S000003752","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL216C"}


id: YJL217W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"REE1","product":"Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle","secondary_identifier":"SGD:S000003753","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL217W"}


id: YJL218W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05413":null,"YJL218W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJL218W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05413","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein, putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in OAF1/PIP2-dependent manner; promoter contains oleate response element consensus sequence; mutation decreases salt tolerance; non-essential gene","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003754","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL218W"}


id: YJL219W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00057":null,"SJAG_02958":null,"SJAG_03606":null,"SJAG_03608":null,"SJAG_03820":null,"SJAG_04068":null,"SJAG_04905":null,"YJL219W":null},"has_protein_features":false,"name":"HXT9","ortholog_annotations":[{"gene_uniquename":"YJL219W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00057","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL219W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02958","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJL219W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03606","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL219W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03608","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL219W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03820","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJL219W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04068","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJL219W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04905","reference_uniquename":"PMID:29761456"}],"product":"Putative hexose transporter that is nearly identical to Hxt11p; has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003755","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL219W"}


id: YJL220W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2","secondary_identifier":"SGD:S000003756","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL220W"}


id: YJL221C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IMA4","product":"Alpha-glucosidase; weak, but broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima4p overexpression allows the ima1 null mutant to grow on isomaltose; identical to IMA3","secondary_identifier":"SGD:S000003757","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL221C"}


id: YJL222W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01488":null,"YJL222W":null},"has_protein_features":false,"name":"VTH2","ortholog_annotations":[{"gene_uniquename":"YJL222W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01488","reference_uniquename":"PMID:29761456"}],"product":"Putative membrane glycoprotein; has strong similarity to Vth1p and Pep1p/Vps10p; may be involved in vacuolar protein sorting","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003758","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL222W"}


id: YJL222W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000028663","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL222W-A"}


id: YJL222W-B
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000028664","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL222W-B"}


id: YJL223C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"PAU1","product":"Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; active during alcoholic fermentation; regulated by anaerobiosis, negatively regulated by oxygen; repressed by heme; identical to Pau14p","secondary_identifier":"SGD:S000003759","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL223C"}


id: YJL225C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative Y' element ATP-dependent helicase","secondary_identifier":"SGD:S000003760","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL225C"}


id: YJL225W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YJL225C","secondary_identifier":"SGD:S000028665","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJL225W-A"}


id: YJR001W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AVT1","product":"Vacuolar transporter; imports large neutral amino acids into vacuole; targeted to vacuole via AP-3 pathway; member of family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters","secondary_identifier":"SGD:S000003761","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR001W"}


id: YJR002W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02681":null,"YJR002W":null},"has_protein_features":false,"name":"MPP10","ortholog_annotations":[{"gene_uniquename":"YJR002W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02681","reference_uniquename":"PMID:29761456"}],"product":"Component of the SSU processome and 90S preribosome; required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003762","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR002W"}


id: YJR003C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MRX12","product":"Protein that associates with mitochondrial ribosome; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis","secondary_identifier":"SGD:S000003763","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR003C"}


id: YJR004C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SAG1","product":"Alpha-agglutinin of alpha-cells; binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor","secondary_identifier":"SGD:S000003764","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR004C"}


id: YJR005C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03924":null,"YJR005C-A":null},"has_protein_features":false,"name":"LSO1","ortholog_annotations":[{"gene_uniquename":"YJR005C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03924","reference_uniquename":"PMID:29761456"}],"product":"Protein with a potential role in response to iron deprivation; transcription increases during iron deprivation and during treatment with 2-(6-benzyl-2-pyridyl)quinazoline (BPQ) and copper; regulated by Aft1p and, to a lesser extent, by Aft2p; originally identified as a syntenic homolog of an Ashbya gossypii gene; localizes to nucleus and cytoplasm, and nuclear localization is enhanced under iron-replete conditions","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028523","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR005C-A"}


id: YJR005W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00104":null,"SJAG_02453":null,"YJR005W":null},"has_protein_features":false,"name":"APL1","ortholog_annotations":[{"gene_uniquename":"YJR005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00104","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR005W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02453","reference_uniquename":"PMID:26896847"}],"product":"Beta-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003765","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR005W"}


id: YJR006W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04877":null,"YJR006W":null},"has_protein_features":false,"name":"POL31","ortholog_annotations":[{"gene_uniquename":"YJR006W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04877","reference_uniquename":"PMID:29761456"}],"product":"Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair; forms a complex with Rev3p, Rev7p and Pol32p; relocalizes to the cytosol in response to hypoxia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003766","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR006W"}


id: YJR007W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03629":null,"YJR007W":null},"has_protein_features":false,"name":"SUI2","ortholog_annotations":[{"gene_uniquename":"YJR007W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03629","reference_uniquename":"PMID:29761456"}],"product":"Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003767","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR007W"}


id: YJR008W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01220":null,"YJR008W":null},"has_protein_features":false,"name":"MHO1","ortholog_annotations":[{"gene_uniquename":"YJR008W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01220","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003768","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR008W"}


id: YJR009C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00027":null,"SJAG_02135":null,"SJAG_02945":null,"SJAG_03828":null,"SJAG_03903":null,"SJAG_06621":null,"SJAG_06622":null,"YJR009C":null},"has_protein_features":false,"name":"TDH2","ortholog_annotations":[{"gene_uniquename":"YJR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00027","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02135","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02945","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03828","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03903","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06621","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR009C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06622","reference_uniquename":"PMID:29761456"}],"product":"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides are active against a wide variety of wine-related yeasts and bateria; TDH2 has a paralog, TDH3, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003769","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR009C"}


id: YJR010C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01750":null,"YJR010C-A":null},"has_protein_features":false,"name":"SPC1","ortholog_annotations":[{"gene_uniquename":"YJR010C-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01750","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); regulates cellular levels of membrane proteins; homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003770","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR010C-A"}


id: YJR010W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03475":null,"YJR010W":null},"has_protein_features":false,"name":"MET3","ortholog_annotations":[{"gene_uniquename":"YJR010W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03475","reference_uniquename":"PMID:29761456"}],"product":"ATP sulfurylase; catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003771","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR010W"}


id: YJR011C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"CAL4","product":"Accessory component of the Ccr4-NOT complex; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS","secondary_identifier":"SGD:S000003772","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR011C"}


id: YJR012C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; null mutant is viable","secondary_identifier":"SGD:S000003773","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR012C"}


id: YJR013W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03115":null,"YJR013W":null},"has_protein_features":false,"name":"GPI14","ortholog_annotations":[{"gene_uniquename":"YJR013W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03115","reference_uniquename":"PMID:29761456"}],"product":"Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I; involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003774","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR013W"}


id: YJR014W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01487":null,"YJR014W":null},"has_protein_features":false,"name":"TMA22","ortholog_annotations":[{"gene_uniquename":"YJR014W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01487","reference_uniquename":"PMID:29761456"}],"product":"Ribosome-associated protein; involved along with heterodimeric partner Tma20p in recycling of 40S ribosomal subunits; involved in nonsense-mediated mRNA decay (NMD); contains a putative RNA binding domain; localizes to the cytoplasm in HTP studies; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003775","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR014W"}


id: YJR015W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; localizes to endoplasmic reticulum and cytoplasm; null mutant exhibits abnormal lipid metabolic phenotype; predicted to encode a membrane transporter based on phylogenetic analysis; not an essential gene; YJR015W has a paralog, SNG1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003776","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR015W"}


id: YJR016C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04098":null,"YJR016C":null},"has_protein_features":false,"name":"ILV3","ortholog_annotations":[{"gene_uniquename":"YJR016C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04098","reference_uniquename":"PMID:29761456"}],"product":"Dihydroxyacid dehydratase; putative 2Fe-2S protein; catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003777","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR016C"}


id: YJR017C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02551":null,"YJR017C":null},"has_protein_features":false,"name":"ESS1","ortholog_annotations":[{"gene_uniquename":"YJR017C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02551","reference_uniquename":"PMID:29761456"}],"product":"Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated S/T residues N-terminal to proline; regulates phosphorylation of RNAPII large subunit (Rpo21p) C-terminal domain (CTD) at Ser7; associates with phospho-Ser5 form of RNAPII in vivo; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription, trimethylation of histone H3; human ortholog PIN1 can complement yeast null and ts mutants","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003778","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR017C"}


id: YJR018W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003779","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR018W"}


id: YJR019C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"TES1","product":"Peroxisomal acyl-CoA thioesterase; likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids","secondary_identifier":"SGD:S000003780","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR019C"}


id: YJR020W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003781","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR020W"}


id: YJR021C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"REC107","product":"Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation","secondary_identifier":"SGD:S000003782","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR021C"}


id: YJR022W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01819":null,"YJR022W":null},"has_protein_features":false,"name":"LSM8","ortholog_annotations":[{"gene_uniquename":"YJR022W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01819","reference_uniquename":"PMID:29761456"}],"product":"Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003783","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR022W"}


id: YJR023C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing","secondary_identifier":"SGD:S000003784","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR023C"}


id: YJR024C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02293":null,"SJAG_02689":null,"YJR024C":null},"has_protein_features":false,"name":"MDE1","ortholog_annotations":[{"gene_uniquename":"YJR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02293","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR024C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02689","reference_uniquename":"PMID:29761456"}],"product":"5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003785","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR024C"}


id: YJR025C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BNA1","product":"3-hydroxyanthranilic acid dioxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p","secondary_identifier":"SGD:S000003786","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR025C"}


id: YJR030C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RBH2","product":"Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; non-essential gene; contains a PH-like domain; RBH2 has a paralog, RBH1, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003791","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR030C"}


id: YJR031C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00858":null,"YJR031C":null},"has_protein_features":false,"name":"GEA1","ortholog_annotations":[{"gene_uniquename":"YJR031C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00858","reference_uniquename":"PMID:29761456"}],"product":"Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003792","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR031C"}


id: YJR032W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04352":null,"YJR032W":null},"has_protein_features":false,"name":"CPR7","ortholog_annotations":[{"gene_uniquename":"YJR032W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04352","reference_uniquename":"PMID:29761456"}],"product":"Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; plays a role in determining prion variants","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003793","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR032W"}


id: YJR033C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00301":null,"YJR033C":null},"has_protein_features":false,"name":"RAV1","ortholog_annotations":[{"gene_uniquename":"YJR033C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00301","reference_uniquename":"PMID:29761456"}],"product":"Subunit of RAVE complex (Rav1p, Rav2p, Skp1p); the RAVE complex promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003794","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR033C"}


id: YJR034W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05199":null,"YJR034W":null},"has_protein_features":false,"name":"PET191","ortholog_annotations":[{"gene_uniquename":"YJR034W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05199","reference_uniquename":"PMID:29761456"}],"product":"Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003795","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR034W"}


id: YJR035W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04114":null,"YJR035W":null},"has_protein_features":false,"name":"RAD26","ortholog_annotations":[{"gene_uniquename":"YJR035W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04114","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in transcription-coupled nucleotide excision repair; repairs UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003796","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR035W"}


id: YJR036C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05264":null,"YJR036C":null},"has_protein_features":false,"name":"HUL4","ortholog_annotations":[{"gene_uniquename":"YJR036C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05264","reference_uniquename":"PMID:29761456"}],"product":"Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003797","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR036C"}


id: YJR037W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces","secondary_identifier":"SGD:S000003798","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR037W"}


id: YJR038C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003799","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR038C"}


id: YJR039W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MLO127","product":"Mitochondrial protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000003800","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR039W"}


id: YJR040W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"GEF1","product":"Voltage-gated chloride channel; localized to the golgi, the endosomal system, and plasma membrane; involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism","secondary_identifier":"SGD:S000003801","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR040W"}


id: YJR041C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03888":null,"YJR041C":null},"has_protein_features":false,"name":"URB2","ortholog_annotations":[{"gene_uniquename":"YJR041C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03888","reference_uniquename":"PMID:29761456"}],"product":"Protein required for normal metabolism of the rRNA primary transcript; nucleolar protein; proposed to be involved in ribosome biogenesis","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003802","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR041C"}


id: YJR042W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00471":null,"YJR042W":null},"has_protein_features":false,"name":"NUP85","ortholog_annotations":[{"gene_uniquename":"YJR042W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00471","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003803","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR042W"}


id: YJR043C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00814":null,"YJR043C":null},"has_protein_features":false,"name":"POL32","ortholog_annotations":[{"gene_uniquename":"YJR043C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00814","reference_uniquename":"PMID:29761456"}],"product":"Third subunit of DNA polymerase delta; involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; parental H3-H4 histone chaperone that mediates transfer of parental histones to the lagging strand via Pol1p during DNA replication; forms a complex with Rev3p, Rev7p and Pol31p; interacts with Hys2p, PCNA (Pol30p), and Pol1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003804","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR043C"}


id: YJR044C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_07012":null,"YJR044C":null},"has_protein_features":false,"name":"VPS55","ortholog_annotations":[{"gene_uniquename":"YJR044C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_07012","reference_uniquename":"PMID:29761456"}],"product":"Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP)","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003805","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR044C"}


id: YJR045C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01615":null,"YJR045C":null},"has_protein_features":false,"name":"SSC1","ortholog_annotations":[{"gene_uniquename":"YJR045C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01615","reference_uniquename":"PMID:29761456"}],"product":"Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003806","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR045C"}


id: YJR046W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02607":null,"YJR046W":null},"has_protein_features":false,"name":"TAH11","ortholog_annotations":[{"gene_uniquename":"YJR046W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02607","reference_uniquename":"PMID:29761456"}],"product":"DNA replication licensing factor; required for pre-replication complex assembly","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003807","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR046W"}


id: YJR047C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02189":null,"SJAG_02812":null,"YJR047C":null},"has_protein_features":false,"name":"ANB1","ortholog_annotations":[{"gene_uniquename":"YJR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02189","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR047C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02812","reference_uniquename":"PMID:29761456"}],"product":"Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication; human EIF5A complements the inviability of the yeast hyp2 anb1 double null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003808","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR047C"}


id: YJR048W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02744":null,"YJR048W":null},"has_protein_features":false,"name":"CYC1","ortholog_annotations":[{"gene_uniquename":"YJR048W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02744","reference_uniquename":"PMID:29761456"}],"product":"Cytochrome c, isoform 1; also known as iso-1-cytochrome c; electron carrier of mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication; human homolog CYC1 can complement yeast null mutant; mutations in human CYC1 cause insulin-responsive hyperglycemia","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003809","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR048W"}


id: YJR049C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01566":null,"SJAG_01582":null,"YJR049C":null},"has_protein_features":false,"name":"UTR1","ortholog_annotations":[{"gene_uniquename":"YJR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01566","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR049C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01582","reference_uniquename":"PMID:29761456"}],"product":"ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003810","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR049C"}


id: YJR050W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01214":null,"YJR050W":null},"has_protein_features":false,"name":"ISY1","ortholog_annotations":[{"gene_uniquename":"YJR050W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01214","reference_uniquename":"PMID:29761456"}],"product":"Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs; interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003811","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR050W"}


id: YJR051W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00203":null,"YJR051W":null},"has_protein_features":false,"name":"OSM1","ortholog_annotations":[{"gene_uniquename":"YJR051W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00203","reference_uniquename":"PMID:29761456"}],"product":"Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; acts as electron acceptor in mitochondrial intermembrane space; has two translation start sites, one at the annotated start codon which produces an ER-targeted form required for anaerobic growth, and one at codon 32 which produces a mitochondrially-targeted form; OSM1 has a paralog, FRD1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003812","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR051W"}


id: YJR052W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03612":null,"YJR052W":null},"has_protein_features":false,"name":"RAD7","ortholog_annotations":[{"gene_uniquename":"YJR052W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03612","reference_uniquename":"PMID:29761456"}],"product":"Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad16p) during NER; required for repair of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003813","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR052W"}


id: YJR053W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04943":null,"YJR053W":null},"has_protein_features":false,"name":"BFA1","ortholog_annotations":[{"gene_uniquename":"YJR053W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04943","reference_uniquename":"PMID:29761456"}],"product":"Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p; contributes to GAP activity, inactivating Tem1 by stimulating GTP hydrolysis following damage or misalignment of the mitotic spindle; functions as a guanine-nucleotide exchange inhibitor (GDI) for Tem1p; involved in multiple cell cycle checkpoint pathways that control mitotic exit; required when telomeres are damaged, but not for all types of chromosomal DNA damage; phosphorylated by the Polo-like kinase Cdc5p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003814","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR053W"}


id: YJR054W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"KCH1","product":"Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; localized to sites of polarized growth; member of a fungal-specific gene family; potential Cdc28p substrate; KCH1 has a paralog, PRM6, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003815","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR054W"}


id: YJR055W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05223":null,"YJR055W":null},"has_protein_features":false,"name":"HIT1","ortholog_annotations":[{"gene_uniquename":"YJR055W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05223","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in C/D snoRNP assembly; critical for formation of small nucleolar ribonucleoprotein complexes that are required for rRNA processing and 2'-O-methylation; regulates abundance of Rsa1p; required for growth at high temperature; mutations in human homolog ZNHIT3 cause PEHO syndrome, a ribosomopathy characterized by extreme cerebellar atrophy","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003816","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR055W"}


id: YJR056C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress","secondary_identifier":"SGD:S000003817","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR056C"}


id: YJR057W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04657":null,"YJR057W":null},"has_protein_features":false,"name":"CDC8","ortholog_annotations":[{"gene_uniquename":"YJR057W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04657","reference_uniquename":"PMID:29761456"}],"product":"Nucleoside monophosphate and nucleoside diphosphate kinase; functions in the de novo biosynthesis of pyrimidine deoxyribonucleotides; thymidylate/uridylate kinase that converts nucleoside monophosphates, dTMP and dUMP to nucleoside diphosphates, dTDP and dUDP; nucleoside diphosphate kinase that converts nucleoside diphosphates, dTDP and dUDP to dTTP and dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe tmp1; human homolog DTYMK can complement the cdc8 null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003818","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR057W"}


id: YJR058C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02805":null,"YJR058C":null},"has_protein_features":false,"name":"APS2","ortholog_annotations":[{"gene_uniquename":"YJR058C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02805","reference_uniquename":"PMID:29761456"}],"product":"Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003819","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR058C"}


id: YJR059W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04469":null,"YJR059W":null},"has_protein_features":false,"name":"PTK2","ortholog_annotations":[{"gene_uniquename":"YJR059W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04469","reference_uniquename":"PMID:29761456"}],"product":"Serine/threonine protein kinase; involved in regulation of ion transport across plasma membrane; carboxyl terminus is essential for glucose-dependent Pma1p activation via phosphorylation of Pma1p-Ser899; enhances spermine uptake; PTK2 has a paralog, PTK1, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003820","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR059W"}


id: YJR060W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01343":null,"YJR060W":null},"has_protein_features":false,"name":"CBF1","ortholog_annotations":[{"gene_uniquename":"YJR060W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01343","reference_uniquename":"PMID:29761456"}],"product":"Basic helix-loop-helix (bHLH) protein; forms homodimer to bind E-box consensus sequence CACGTG present at MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins, required for chromosome segregation; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003821","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR060W"}


id: YJR061W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"MNN14","product":"Protein required for N-glycan mannosylphosphorylation; non-essential gene; transcription repressed by Rm101p; MNN14 has a paralog, MNN4, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003822","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR061W"}


id: YJR062C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00476":null,"YJR062C":null},"has_protein_features":false,"name":"NTA1","ortholog_annotations":[{"gene_uniquename":"YJR062C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00476","reference_uniquename":"PMID:29761456"}],"product":"Amidase; removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003823","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR062C"}


id: YJR063W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04106":null,"YJR063W":null},"has_protein_features":false,"name":"RPA12","ortholog_annotations":[{"gene_uniquename":"YJR063W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04106","reference_uniquename":"PMID:29761456"}],"product":"RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003824","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR063W"}


id: YJR064W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03320":null,"YJR064W":null},"has_protein_features":false,"name":"CCT5","ortholog_annotations":[{"gene_uniquename":"YJR064W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03320","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003825","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR064W"}


id: YJR065C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01268":null,"YJR065C":null},"has_protein_features":false,"name":"ARP3","ortholog_annotations":[{"gene_uniquename":"YJR065C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01268","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003826","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR065C"}


id: YJR066W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02723":null,"SJAG_03067":null,"YJR066W":null},"has_protein_features":false,"name":"TOR1","ortholog_annotations":[{"gene_uniquename":"YJR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02723","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR066W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03067","reference_uniquename":"PMID:29761456"}],"product":"PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; indole-3-acetic acid, an ATP-competitive TORC1 inhibitor, accumulates upon entry into stationary phase; malonyl-CoA is a direct ATP-competitive inhibitor of TORC1; TOR1 has a paralog, TOR2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003827","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR066W"}


id: YJR067C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03913":null,"YJR067C":null},"has_protein_features":false,"name":"YAE1","ortholog_annotations":[{"gene_uniquename":"YJR067C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03913","reference_uniquename":"PMID:29761456"}],"product":"Substrate-specific adaptor protein involved in apo-Rli1p maturation; subunit of the Yae1-Lto1 complex, recruiting apo-Rli1p to the CIA targeting complex, facilitating the insertion of an Fe/S cluster by the Fe-S biosynthetic machinery; deca-GX3 motif crucial for complex formation; essential for aerobic but not anaerobic growth; homolog of human YAE1D1, which is overexpressed in oral cancers; co-expression of YAE1D1 and LTO1 homolog ORAOV1 restores growth and Rli1p maturation after YAE1 depletion","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003828","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR067C"}


id: YJR068W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01010":null,"YJR068W":null},"has_protein_features":false,"name":"RFC2","ortholog_annotations":[{"gene_uniquename":"YJR068W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01010","reference_uniquename":"PMID:29761456"}],"product":"Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003829","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR068W"}


id: YJR069C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03797":null,"YJR069C":null},"has_protein_features":false,"name":"HAM1","ortholog_annotations":[{"gene_uniquename":"YJR069C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03797","reference_uniquename":"PMID:29761456"}],"product":"Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003830","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR069C"}


id: YJR070C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02285":null,"YJR070C":null},"has_protein_features":false,"name":"LIA1","ortholog_annotations":[{"gene_uniquename":"YJR070C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02285","reference_uniquename":"PMID:29761456"}],"product":"Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003831","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR070C"}


id: YJR071W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data","secondary_identifier":"SGD:S000003832","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR071W"}


id: YJR072C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04531":null,"YJR072C":null},"has_protein_features":false,"name":"NPA3","ortholog_annotations":[{"gene_uniquename":"YJR072C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04531","reference_uniquename":"PMID:29761456"}],"product":"Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003833","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR072C"}


id: YJR073C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00812":null,"YJR073C":null},"has_protein_features":false,"name":"OPI3","ortholog_annotations":[{"gene_uniquename":"YJR073C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00812","reference_uniquename":"PMID:29761456"}],"product":"Methylene-fatty-acyl-phospholipid synthase; catalyzes the last two steps in phosphatidylcholine biosynthesis; also known as phospholipid methyltransferase","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003834","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR073C"}


id: YJR074W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03002":null,"YJR074W":null},"has_protein_features":false,"name":"MOG1","ortholog_annotations":[{"gene_uniquename":"YJR074W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03002","reference_uniquename":"PMID:29761456"}],"product":"Conserved nuclear protein that interacts with GTP-Gsp1p; stimulates nucleotide release from Gsp1p; involved in nuclear protein import; nucleotide release is inhibited by Yrb1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003835","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR074W"}


id: YJR075W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04770":null,"YJR075W":null},"has_protein_features":false,"name":"HOC1","ortholog_annotations":[{"gene_uniquename":"YJR075W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04770","reference_uniquename":"PMID:29761456"}],"product":"Alpha-1,6-mannosyltransferase; involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003836","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR075W"}


id: YJR076C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04375":null,"SJAG_04470":null,"YJR076C":null},"has_protein_features":false,"name":"CDC11","ortholog_annotations":[{"gene_uniquename":"YJR076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04375","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR076C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04470","reference_uniquename":"PMID:26896847"}],"product":"Component of the septin ring that is required for cytokinesis; present at the ends of rod-like septin hetero-oligomers; C-terminal extension is important for recruitment of Bni5p to the mother-bud neck, which in turn is required for Myo1p recruitment and cytokinesis; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003837","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR076C"}


id: YJR077C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00547":null,"YJR077C":null},"has_protein_features":false,"name":"MIR1","ortholog_annotations":[{"gene_uniquename":"YJR077C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00547","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial phosphate carrier; imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003838","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR077C"}


id: YJR078W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"BNA2","product":"Tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase; required for de novo biosynthesis of NAD+ from tryptophan via kynurenine; up-regulated by telomere uncapping, and interacts genetically with capping gene CDC13; overexpression reduces lipid droplet accumulation by skewing glycolytic flux towards biosynthesis of shikimate, aromatic amino acids, and NAD+ during aging and extends lifespan; regulated by Hst1p and Aftp","secondary_identifier":"SGD:S000003839","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR078W"}


id: YJR079W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; mutation results in impaired mitochondrial respiration","secondary_identifier":"SGD:S000003840","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR079W"}


id: YJR080C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"AIM24","product":"Protein with a role in determining mitochondrial architecture; inner membrane protein that interacts physically and genetically with the MICOS complex and is required for its integrity","secondary_identifier":"SGD:S000003841","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR080C"}


id: YJR082C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01385":null,"YJR082C":null},"has_protein_features":false,"name":"EAF6","ortholog_annotations":[{"gene_uniquename":"YJR082C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01385","reference_uniquename":"PMID:29761456"}],"product":"Subunit of the NuA4 acetyltransferase complex; this complex acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003842","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR082C"}


id: YJR083C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ACF4","product":"Protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate","secondary_identifier":"SGD:S000003843","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR083C"}


id: YJR084W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00298":null,"SJAG_04347":null,"YJR084W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJR084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00298","reference_uniquename":"PMID:26896847"},{"gene_uniquename":"YJR084W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04347","reference_uniquename":"PMID:29761456"}],"product":"Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome","references_by_uniquename":{"PMID:26896847":null,"PMID:29761456":null},"secondary_identifier":"SGD:S000003844","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR084W"}


id: YJR085C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04515":null,"YJR085C":null},"has_protein_features":false,"name":"TMH11","ortholog_annotations":[{"gene_uniquename":"YJR085C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04515","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003845","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR085C"}


id: YJR086W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"STE18","product":"G protein gamma subunit; forms dimer with Ste4p to activate mating signaling pathway, heterotrimer with Gpa1p, Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling; N-terminal phosphorylation of Ste18p functions synergistically with Fus3p docking site on Ste5p to restrict Ste5p plasma membrane recruitment and signaling; combinatorial phosphorylation at S3 and S7, by pheromone and pH stress, modulates Ste18p structure, Fus3p activation","secondary_identifier":"SGD:S000003846","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR086W"}


id: YJR087W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2","secondary_identifier":"SGD:S000003847","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR087W"}


id: YJR088C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02065":null,"YJR088C":null},"has_protein_features":false,"name":"EMC2","ortholog_annotations":[{"gene_uniquename":"YJR088C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02065","reference_uniquename":"PMID:29761456"}],"product":"Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003848","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR088C"}


id: YJR089W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04412":null,"YJR089W":null},"has_protein_features":false,"name":"BIR1","ortholog_annotations":[{"gene_uniquename":"YJR089W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04412","reference_uniquename":"PMID:29761456"}],"product":"Subunit of chromosomal passenger complex (CPC); CPC is comprised of Ipl1p-Sli15p-Bir1p-Nbl1p and regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension; relative distribution to shortened microtubules increases upon DNA replication stress; sumoylated in an Mms21p-dependent manner; human survivin homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003849","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR089W"}


id: YJR090C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00651":null,"YJR090C":null},"has_protein_features":false,"name":"GRR1","ortholog_annotations":[{"gene_uniquename":"YJR090C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00651","reference_uniquename":"PMID:29761456"}],"product":"F-box protein component of an SCF ubiquitin-ligase complex; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCF(Grr1) complex; SCF(Grr1) acts as a ubiquitin-protein ligase directing ubiquitination of substrates such as: Gic2p, Mks1p, Mth1p, Cln1p, Cln2p and Cln3p; involved in carbon catabolite repression, glucose-dependent divalent cation transport, glucose transport, morphogenesis, and sulfite detoxification","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003850","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR090C"}


id: YJR091C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00391":null,"SJAG_16457":null,"YJR091C":null},"has_protein_features":false,"name":"JSN1","ortholog_annotations":[{"gene_uniquename":"YJR091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00391","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR091C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_16457","reference_uniquename":"PMID:29761456"}],"product":"Member of the Puf family of RNA-binding proteins; interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl; JSN1 has a paralog, PUF2, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003851","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR091C"}


id: YJR092W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00118":null,"SJAG_01143":null,"YJR092W":null},"has_protein_features":false,"name":"BUD4","ortholog_annotations":[{"gene_uniquename":"YJR092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00118","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR092W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01143","reference_uniquename":"PMID:29761456"}],"product":"Anillin-like protein involved in bud-site selection; required for the axial budding pattern; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; functions as a platform linking the cytokinesis tag septins to the axial landmark through its multiple domains; in vivo substrate of Cdc28p/Clb2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003852","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR092W"}


id: YJR093C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00961":null,"YJR093C":null},"has_protein_features":false,"name":"FIP1","ortholog_annotations":[{"gene_uniquename":"YJR093C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00961","reference_uniquename":"PMID:29761456"}],"product":"Subunit of cleavage polyadenylation factor (CPF); interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003853","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR093C"}


id: YJR094C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"IME1","product":"Master regulator of meiosis that is active only during meiotic events; activates transcription of early meiotic genes through interaction with Ume6p; regulator of meiotic commitment; degraded by the 26S proteasome following phosphorylation by Ime2p; transcription is negatively regulated in cis by the IRT1 long noncoding antisense RNA","secondary_identifier":"SGD:S000003854","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR094C"}


id: YJR094W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02510":null,"SJAG_03043":null,"YJR094W-A":null},"has_protein_features":false,"name":"RPL43B","ortholog_annotations":[{"gene_uniquename":"YJR094W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02510","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR094W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03043","reference_uniquename":"PMID:29761456"}],"product":"Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003855","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR094W-A"}


id: YJR095W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"SFC1","product":"Mitochondrial succinate-fumarate transporter; transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization","secondary_identifier":"SGD:S000003856","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR095W"}


id: YJR096W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03958":null,"SJAG_04660":null,"YJR096W":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03958","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR096W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04660","reference_uniquename":"PMID:29761456"}],"product":"Xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003857","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR096W"}


id: YJR097W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00251":null,"YJR097W":null},"has_protein_features":false,"name":"JJJ3","ortholog_annotations":[{"gene_uniquename":"YJR097W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00251","reference_uniquename":"PMID:29761456"}],"product":"Iron-binding protein; involved in targeting cytoplasmic SRP-independent proteins to the ER; contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003858","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR097W"}


id: YJR098C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies","secondary_identifier":"SGD:S000003859","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR098C"}


id: YJR099W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00795":null,"YJR099W":null},"has_protein_features":false,"name":"YUH1","ortholog_annotations":[{"gene_uniquename":"YJR099W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00795","reference_uniquename":"PMID:29761456"}],"product":"Ubiquitin C-terminal hydrolase; cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003860","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR099W"}


id: YJR100C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01470":null,"YJR100C":null},"has_protein_features":false,"name":"AIM25","ortholog_annotations":[{"gene_uniquename":"YJR100C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01470","reference_uniquename":"PMID:29761456"}],"product":"Mitochondria protein of unknown function; interacts genetically with TOR1 to regulate chronological lifespan, and the response to both heat shock and oxidative stress; involved in maintaining the integrity of the mitochondrial network; negative regulator of mitophagy flux; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant is viable and displays an elevated frequency of mitochondrial genome loss; similar to murine NOR1","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003861","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR100C"}


id: YJR101W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01734":null,"SJAG_04788":null,"YJR101W":null},"has_protein_features":false,"name":"RSM26","ortholog_annotations":[{"gene_uniquename":"YJR101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01734","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR101W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04788","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003862","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR101W"}


id: YJR102C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04912":null,"YJR102C":null},"has_protein_features":false,"name":"VPS25","ortholog_annotations":[{"gene_uniquename":"YJR102C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04912","reference_uniquename":"PMID:29761456"}],"product":"Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003863","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR102C"}


id: YJR103W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_05024":null,"YJR103W":null},"has_protein_features":false,"name":"URA8","ortholog_annotations":[{"gene_uniquename":"YJR103W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_05024","reference_uniquename":"PMID:29761456"}],"product":"Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003864","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR103W"}


id: YJR104C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00668":null,"YJR104C":null},"has_protein_features":false,"name":"SOD1","ortholog_annotations":[{"gene_uniquename":"YJR104C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00668","reference_uniquename":"PMID:29761456"}],"product":"Cytosolic copper-zinc superoxide dismutase; also sulfide oxidase; detoxifies superoxide and hydrogen sulfide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; abundance increases under DNA replication stress; localization to mitochondrial intermembrane space is modulated by MICOS complex; human ortholog SOD1 implicated in ALS complements a null allele","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003865","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR104C"}


id: YJR105W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01070":null,"YJR105W":null},"has_protein_features":false,"name":"ADO1","ortholog_annotations":[{"gene_uniquename":"YJR105W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01070","reference_uniquename":"PMID:29761456"}],"product":"Adenosine kinase; required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003866","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR105W"}


id: YJR106W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_04892":null,"YJR106W":null},"has_protein_features":false,"name":"ECM27","ortholog_annotations":[{"gene_uniquename":"YJR106W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_04892","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003867","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR106W"}


id: YJR107C-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Protein of unknown function; encodes new type of domain, which ab initio modeling suggests is predominantly alpha-helical; nonessential for growth, deletion increases sensitivity to osmostress; expressed at moderate to high abundance; ORF also present in strains EC1118, YJM789, RM11-1a, and AWRI1631; Gln24 in S288C reference is substituted with Arg in wine strain EC1118; predicted S-palmitoylation site on Cys2, suggesting membrane association; transcript previously mischaracterized as SUT646","secondary_identifier":"SGD:S000303810","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR107C-A"}


id: YJR107W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"LIH1","product":"Putative lipase","secondary_identifier":"SGD:S000003868","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR107W"}


id: YJR108W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"ABM1","product":"Protein of unknown function; required for normal microtubule organization","secondary_identifier":"SGD:S000003869","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR108W"}


id: YJR109C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00412":null,"YJR109C":null},"has_protein_features":false,"name":"CPA2","ortholog_annotations":[{"gene_uniquename":"YJR109C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00412","reference_uniquename":"PMID:29761456"}],"product":"Large subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003870","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR109C"}


id: YJR110W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03248":null,"YJR110W":null},"has_protein_features":false,"name":"YMR1","ortholog_annotations":[{"gene_uniquename":"YJR110W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03248","reference_uniquename":"PMID:29761456"}],"product":"Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003871","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR110W"}


id: YJR111C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02630":null,"YJR111C":null},"has_protein_features":false,"name":"PXP2","ortholog_annotations":[{"gene_uniquename":"YJR111C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02630","reference_uniquename":"PMID:29761456"}],"product":"Peroxisomal matrix protein with naturally active promoter; well-conserved in fungi; localized to peroxisomes under physiological growth conditions; levels of some amino acids are altered upon both knockout and overexpression, suggesting potential involvement of Pxp2p in amino acid metabolism or related cellular metabolic processes (needs further study); GFP-fusion protein displays inherent dual localization with large proportion localizing to cytosol","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003872","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR111C"}


id: YJR112W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00418":null,"YJR112W":null},"has_protein_features":false,"name":"NNF1","ortholog_annotations":[{"gene_uniquename":"YJR112W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00418","reference_uniquename":"PMID:29761456"}],"product":"Essential component of the outer kinetochore MIND complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for kinetochore bi-orientation and accurate chromosome segregation; complex consists of Mtw1p, Nnf1p, Nsl1p and Dsn1p; homologous to metazoan CENP-H proteins","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003873","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR112W"}


id: YJR112W-A
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00215":null,"YJR112W-A":null},"has_protein_features":false,"ortholog_annotations":[{"gene_uniquename":"YJR112W-A","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00215","reference_uniquename":"PMID:29761456"}],"product":"Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; identified based on homology to <i>Ashbya gossypii</i>","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000028513","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR112W-A"}


id: YJR113C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00513":null,"YJR113C":null},"has_protein_features":false,"name":"RSM7","ortholog_annotations":[{"gene_uniquename":"YJR113C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00513","reference_uniquename":"PMID:29761456"}],"product":"Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S7 ribosomal protein","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003874","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR113C"}


id: YJR114W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C","secondary_identifier":"SGD:S000003875","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR114W"}


id: YJR115W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication","secondary_identifier":"SGD:S000003876","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR115W"}


id: YJR116W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01912":null,"YJR116W":null},"has_protein_features":false,"name":"TDA4","ortholog_annotations":[{"gene_uniquename":"YJR116W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01912","reference_uniquename":"PMID:29761456"}],"product":"Protein distantly similar to ceramide synthases, Lag1p and Lac1p; null mutant is sensitive to expression of the top1-T722A allele; mutation confers sensitivity to copper","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003877","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR116W"}


id: YJR117W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03396":null,"YJR117W":null},"has_protein_features":false,"name":"STE24","ortholog_annotations":[{"gene_uniquename":"YJR117W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03396","reference_uniquename":"PMID:29761456"}],"product":"Highly conserved zinc metalloprotease; component of the ER quality control mechanism that removes faulty proteins clogging translocation channels; inhibits SRP-independent translocation into the ER; has two roles in a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; cleaves isoprenylated and non-prenylated oligopeptides; human homolog ZMPSTE24 implicated in mandibuloacral dysplasia (MAD), and complements the null mutant","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003878","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR117W"}


id: YJR118C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00127":null,"YJR118C":null},"has_protein_features":false,"name":"ILM1","ortholog_annotations":[{"gene_uniquename":"YJR118C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00127","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003879","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR118C"}


id: YJR119C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03286":null,"YJR119C":null},"has_protein_features":false,"name":"JHD2","ortholog_annotations":[{"gene_uniquename":"YJR119C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03286","reference_uniquename":"PMID:29761456"}],"product":"JmjC domain family histone demethylase; promotes global demethylation of H3K4 and represses noncoding intergenic transcription during sporulation; removes methyl groups added by Set1p; phosphorylation by Tpk2p during glycolysis inhibits activity, nuclear localization, chromatin binding and promotes Not4p Ub-mediated degradation; negatively regulated by H3K14 acetylation; regulates sporulation timing by extending period of active transcription; regulates rDNA silencing; human homolog is JARID1C","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003880","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR119C"}


id: YJR120W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"DMO1","product":"Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p","secondary_identifier":"SGD:S000003881","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR120W"}


id: YJR121W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02598":null,"YJR121W":null},"has_protein_features":false,"name":"ATP2","ortholog_annotations":[{"gene_uniquename":"YJR121W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02598","reference_uniquename":"PMID:29761456"}],"product":"Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003882","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR121W"}


id: YJR122W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02306":null,"YJR122W":null},"has_protein_features":false,"name":"IBA57","ortholog_annotations":[{"gene_uniquename":"YJR122W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02306","reference_uniquename":"PMID:29761456"}],"product":"Protein involved in incorporating iron-sulfur clusters into proteins; mitochondrial matrix protein; involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003883","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR122W"}


id: YJR123W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_00523":null,"SJAG_02477":null,"YJR123W":null},"has_protein_features":false,"name":"RPS5","ortholog_annotations":[{"gene_uniquename":"YJR123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_00523","reference_uniquename":"PMID:29761456"},{"gene_uniquename":"YJR123W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02477","reference_uniquename":"PMID:29761456"}],"product":"Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003884","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR123W"}


id: YJR124C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; expression induced under calcium shortage","secondary_identifier":"SGD:S000003885","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR124C"}


id: YJR125C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02177":null,"YJR125C":null},"has_protein_features":false,"name":"ENT3","ortholog_annotations":[{"gene_uniquename":"YJR125C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02177","reference_uniquename":"PMID:29761456"}],"product":"Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003886","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR125C"}


id: YJR126C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_02117":null,"YJR126C":null},"has_protein_features":false,"name":"VPS70","ortholog_annotations":[{"gene_uniquename":"YJR126C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_02117","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function involved in vacuolar protein sorting; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003887","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR126C"}


id: YJR127C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"name":"RSF2","product":"Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress","secondary_identifier":"SGD:S000003888","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR127C"}


id: YJR128W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"has_protein_features":false,"product":"Putative protein of unknown function; conserved among S. cerevisiae strains; partially overlaps the verified ORF RSF2","secondary_identifier":"SGD:S000003889","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR128W"}


id: YJR129C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_01536":null,"YJR129C":null},"has_protein_features":false,"name":"EFM3","ortholog_annotations":[{"gene_uniquename":"YJR129C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_01536","reference_uniquename":"PMID:29761456"}],"product":"S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which trimethylates translation elongation factor EF2 (Eft1p and Eft2p) at lysine 509; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; ortholog of human gene FAM86A","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003890","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR129C"}


id: YJR130C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03102":null,"YJR130C":null},"has_protein_features":false,"name":"STR2","ortholog_annotations":[{"gene_uniquename":"YJR130C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03102","reference_uniquename":"PMID:29761456"}],"product":"Cystathionine gamma-synthase, converts cysteine into cystathionine; STR2 has a paralog, YML082W, that arose from the whole genome duplication","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003891","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR130C"}


id: YJR131W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03032":null,"YJR131W":null},"has_protein_features":false,"name":"MNS1","ortholog_annotations":[{"gene_uniquename":"YJR131W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03032","reference_uniquename":"PMID:29761456"}],"product":"Alpha-1,2-mannosidase; involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003892","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR131W"}


id: YJR132W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03693":null,"YJR132W":null},"has_protein_features":false,"name":"NMD5","ortholog_annotations":[{"gene_uniquename":"YJR132W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03693","reference_uniquename":"PMID:29761456"}],"product":"Karyopherin; a carrier protein involved in nuclear import of proteins; importin beta homolog","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003893","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR132W"}


id: YJR133W
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_06634":null,"YJR133W":null},"has_protein_features":false,"name":"XPT1","ortholog_annotations":[{"gene_uniquename":"YJR133W","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_06634","reference_uniquename":"PMID:29761456"}],"product":"Xanthine-guanine phosphoribosyl transferase; required for xanthine utilization and for optimal utilization of guanine","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003894","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR133W"}


id: YJR134C
data:
  {"cv_annotations":{},"deletion_viability":"unknown","feature_so_termid":"SO:0000704","feature_type":"gene","flags":["not_load_organism"],"genes_by_uniquename":{"SJAG_03842":null,"YJR134C":null},"has_protein_features":false,"name":"SGM1","ortholog_annotations":[{"gene_uniquename":"YJR134C","ortholog_taxonid":4897,"ortholog_uniquename":"SJAG_03842","reference_uniquename":"PMID:29761456"}],"product":"Protein of unknown function; required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus","references_by_uniquename":{"PMID:29761456":null},"secondary_identifier":"SGD:S000003895","taxonid":4932,"taxonomic_distribution":"not curated","transcript_so_termid":null,"uniquename":"YJR134C"}


